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See detailA deterministic/stochastic model to predict the variation in bulk modulus of chalk
Collin, Frédéric ULg; Schroeder, Christian ULg; De Gennaro, Vincenzo et al

in Geotechnique (2005), 55(2), 135-141

Ekofisk, located 200 km west of the Norwegian coast, is one of the main oilfields in the North Sea. Since the early 1980s severe compaction of chalk reservoir layers has been observed as a consequence of ... [more ▼]

Ekofisk, located 200 km west of the Norwegian coast, is one of the main oilfields in the North Sea. Since the early 1980s severe compaction of chalk reservoir layers has been observed as a consequence of reservoir depletion during oil production. Subsequently, this compaction has been amplified by assisted oil recovery using seawater flooding. The development of our understanding of the inherent mechanisms of this phenomenon has been the objective of extensive experimental investigations in the last two decades. Owing to the very high cost of cored material from the reservoir, experiments are usually performed on chalk samples from an outcrop in Belgium lying at the same stratigraphic level as the Ekofisk reservoir chalks. However, even at the laboratory sample scale,. experimental variability of material response is observed. From a theoretical and numerical point of view, the determination of the mechanical properties of the material is of utmost importance for accurate modelling at both sample scale (laboratory tests) and reservoir scale. The aim of this paper is to introduce a stochastic approach within a deterministic constitutive model of chalk to enable the influence of material heterogeneity to be included in analyses for the range of observed mechanical responses. In modelling the random distribution of material parameters, the time-consuming Monte Carlo simulation method is replaced by a more efficient stochastic modelling technique. The results are given in the form of statistical parameters for the experimental laboratory test responses. The parameters of the distribution law (mean value, range of variation, spatial correlation structure) are fitted to reproduce the range of experimental responses observed at sample scale. Interest is focused on the variability of the chalk bulk modulus, as observed during isotropic compression tests. The proposed methodology provides a satisfactory explanation for the variability of response observed at the sample scale. The potential for extending the proposed approach to reservoir scale is briefly discussed. [less ▲]

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See detailField scale N-management : soil and plant diagnostic tools applied within the Agricultural Surface Survey
Courtois, Pierre; Destain, Jean-Pierre ULg; Renard, Sophie et al

in Schröder, J. J.; Neetson, J. J. (Eds.) N management in agrosystems in relation to the Water Framework Directive (2005)

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See detailUrbanisme et police générale, sous C.E., 18 août 2004, ASBL Ardennes Liégeoises, 134321
Pâques, Michel ULg

in Aménagement - Environnement (2005), 1

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See detailEin Herz und eine Seele
Pontzen, Alexandra ULg

in Kiesow; Korte (Eds.) EGB. Emotionales Gesetzbuch. Dekalog der Gefühle (2005)

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See detailBiological control of Psoroptes ovis using entomopathogenic fungi
Lekimme, M.; Mignon, Bernard ULg; Focant, C. et al

Poster (2005)

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See detailRange-dependence compensation in bistatic radar STAP
Lapierre, Fabian D.; Verly, Jacques ULg

Conference (2005)

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See detailTélévision et populisme
Jamin, Jérôme ULg

Conference given outside the academic context (2005)

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See detailAscididemin and meridine stabilise G-quadruplexes and inhibit telomerase in vitro
Guittat, Lionel; De Cian, Anne; Rosu, Frédéric ULg et al

in Biochimica et Biophysica Acta - General Subjects (2005), 1724(3), 375-384

Ascididemin and Meridine are two marine compounds with pyridoacridine skeletons known to exhibit interesting antitumour activities. These molecules have been reported to behave like DNA intercalators. In ... [more ▼]

Ascididemin and Meridine are two marine compounds with pyridoacridine skeletons known to exhibit interesting antitumour activities. These molecules have been reported to behave like DNA intercalators. In this study, dialysis competition assay and mass spectrometry experiments were used to determine the affinity of ascididemin and meridine for DNA structures among duplexes, triplexes, quadruplexes and single-strands. Our data confirm that ascididemin and meridine interact with DNA but also recognize triplex and quadruplex structures. These molecules exhibit a significant preference for quadruplexes over duplexes or single-strands. Meridine is a stronger quadruplex ligand and therefore a stronger telomerase inhibitor than ascididemin (IC50= 11 and > 80 mu M, respectively in a standard TRAP assay). (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailEstimation of genetic parameters for test day records of dairy traits in the first three lactations.
Druet, Tom ULg; Jaffrezic, Florence; Ducrocq, Vincent

in Genetics, Selection, Evolution (2005), 37(3), 257-71

Application of test-day models for the genetic evaluation of dairy populations requires the solution of large mixed model equations. The size of the (co)variance matrices required with such models can be ... [more ▼]

Application of test-day models for the genetic evaluation of dairy populations requires the solution of large mixed model equations. The size of the (co)variance matrices required with such models can be reduced through the use of its first eigenvectors. Here, the first two eigenvectors of (co)variance matrices estimated for dairy traits in first lactation were used as covariables to jointly estimate genetic parameters of the first three lactations. These eigenvectors appear to be similar across traits and have a biological interpretation, one being related to the level of production and the other to persistency. Furthermore, they explain more than 95% of the total genetic variation. Variances and heritabilities obtained with this model were consistent with previous studies. High correlations were found among production levels in different lactations. Persistency measures were less correlated. Genetic correlations between second and third lactations were close to one, indicating that these can be considered as the same trait. Genetic correlations within lactation were high except between extreme parts of the lactation. This study shows that the use of eigenvectors can reduce the rank of (co)variance matrices for the test-day model and can provide consistent genetic parameters. [less ▲]

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See detailNovel treatments for drug-induced toxic epidermal necrolysis (Lyell's syndrome).
Paquet, Philippe ULg; Pierard, Gérald ULg; Quatresooz, Pascale ULg

in International Archives of Allergy & Immunology (2005), 136(3), 205-16

Drug-induced toxic epidermal necrolysis (TEN) is a life-threatening disease characterized by extensive destruction of the epidermis. It apparently results from the formation of specific toxic drug ... [more ▼]

Drug-induced toxic epidermal necrolysis (TEN) is a life-threatening disease characterized by extensive destruction of the epidermis. It apparently results from the formation of specific toxic drug metabolites by the keratinocytes. The mortality rate which averages 25-30% is mainly due to secondary septicemia, and to ionic and metabolic disturbances following loss of epidermal integrity. Apoptosis is the likely mechanism leading to massive keratinocyte death in TEN. Dysregulations in the tumor necrosis factor-alpha (TNF-alpha) pathway, CD95 system (Fas ligand, CD95L; Fas receptor, CD95R) and calcium homeostasis in the epidermis are involved in this apoptotic process. An active role has also been ascribed to T lymphocytes, macrophages and factor XIIIa-positive dermal dendrocytes. Despite progress, treatment of TEN remains controversial. In the past, systemic glucocorticoids were used in order to target the inflammatory reaction in TEN. However, there was no evidence for improvement of the healing process, while corticosteroids worsened the prognosis by increasing the risk of septicemia. Only a few cases have been treated with other drugs including cyclophosphamide, pentoxyfilline, thalidomide, anti-TNF-alpha antibodies and cyclosporin A. In the recent past, some TEN patients were treated with intravenous human immunoglobulins (IVIG). The rationale for such a treatment was to block the CD95 system on keratinocytes. The early promising clinical results of IVIG treatment in TEN were subsequently challenged. This review compares the effectiveness and drawbacks of the major drugs presently used in TEN treatment. Some future prospects in TEN management are also discussed. [less ▲]

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See detailCognition, motivation and emotion : Dynamics in the academic environment : Fedora Psyche Conference in Lisbon, 2002
Rott, Gerhart; Figueiredo Dias, Graça; Broonen, Jean-Paul ULg

Book published by Fedora (2005)

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See detailStriae distensae in darker skin types: the influence of melanocyte mechanobiology.
Pierard, Claudine ULg; Hermanns, Jean-François ULg; Hermanns-Lê, Trinh ULg et al

in Journal of Cosmetic Dermatology (2005), 4(3), 174-8

Introduction Striae distensae in White people are commonly described as being reddish at first and turning white in time. This dual perception has been challenged. Indeed, the color difference between ... [more ▼]

Introduction Striae distensae in White people are commonly described as being reddish at first and turning white in time. This dual perception has been challenged. Indeed, the color difference between striae distensae and their surrounding skin varies on a wide range in part depending upon typology. Aim To study striae nigrae that are found only in subjects of darker complexion. Materials and methods In the present study conducted in 44 darker skin adults, dermoscopy was combined to reflectance colorimetry. Results Striae nigrae exhibited hypermelanosis of the epidermal rete ridges crossing transversally the lesions in a laddering pattern. By contrast, striae albae showed only faint melanotic networks. Conclusions As striae distensae are in part under the influence of skin stretching, their colors are likely to be controlled by some mechanobiological process activating or inhibiting melanogenesis in people of darker complexion. No argument involving an inflammatory mechanism is supported by the present observations. [less ▲]

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See detailE-services and offline fulfillment: How loyalty is created
Semein, Janjaap; Van Riel, Allard ULg; Van Birgelen, Marcel

in Managing Service Quality (2005), 15(2), 182-194

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See detailConséquences psychologiques et neuropsychologiques de lésions cérébrales consécutives à un traumatisme crânien
DELRUE, Gaël ULg; QUINET, Magali

Conference given outside the academic context (2005)

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See detail4. Il senso della fine nel “Robinson Crusoe” di Daniel Defoe
Benzoni, Pietro ULg

in Strumenti critici (2005), 107(1), 101-126

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See detailEvaluation de la condition sportive du cheval de complet sur le terrain
Van Erck, Emmanuelle; de Moffaerts, Brieuc; Art, Tatiana ULg et al

in Proceedings du Congrès Annuel A.V.E.F. (2005)

Detailed reference viewed: 13 (2 ULg)