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See detail"D'un mur à l'autre", note sous l'avis de la Cour internationale de Justice du 9 juillet 2004 sur les conséquences juridiques de l'édification d'un mur dans le territoire palestinien occupé
Vincent, Philippe ULg

in Revue de la Faculté de Droit de l'Université de Liège (2005), 1

Analyse de l'avis rendu le 9 juillet 2004 sur la question de la légalité du mur de séparation construit par l'Etat d'Israêl.

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See detailLes limites de la liberté
Jamin, Jérôme ULg

Article for general public (2005)

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See detailSedimentary dynamics and bedload transport in the Semois River (Ardenne, Belgium)
Gob, Frédéric ULg; Houbrechts, Geoffrey ULg; Petit, François ULg

in River Research & Applications (2005), 21(7), 791-804

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See detailMamluk Era Documentary Studies: The State of the Art
Bauden, Frédéric ULg

in Mamlūk Studies Review (2005), IX(1), 15-60

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See detailMMP-9 regulates both positively and negatively collagen gel contraction - A nonproteolytic function of MMP-9
Defawe, Olivier D; Kenagy, Richard D; Choi, Chun et al

in Cardiovascular Research (2005), 66(2), 402-409

Objective: Constrictive remodeling accounts for lumen loss in postangioplasty restenosis. Matrix metalloproteinase-9 (MMP-9) has been shown to prevent constrictive remodeling in vivo. To investigate ... [more ▼]

Objective: Constrictive remodeling accounts for lumen loss in postangioplasty restenosis. Matrix metalloproteinase-9 (MMP-9) has been shown to prevent constrictive remodeling in vivo. To investigate potential mechanisms for this observation, we investigated the role of MMP-9 in smooth muscle cell (SMC)-mediated collagen gel contraction, an in vitro model of constrictive remodeling. Methods: Fischer rat SMCs were stably transfected with a construct-expressing rat-MMP-9 under the control of a tetracycline (Tet)-off promoter. SMCs were seeded in type 1 collagen gels (2.4 mg/ml) in the presence or not of tetracycline (1 mu g/ml), and gel contraction was defined as the percentage of retraction of the collagen gel. The depletion of MMP-9 was obtained by using siRNA targeting MMP-9 mRNA or a blocking antibody. Results: Gel contraction was significantly reduced at all times when MMP-9 was overexpressed (Tet-) as compared with the control condition (Tet+). However, MMP-9 depletion of control (Tet+) SMCS (using siRNA or antibody) also inhibited gel contraction. To resolve the apparent discrepancy and determine if MMP-9 exerts a dose-dependent biphasic effect on gel contraction, conditioned medium and purified rat-MMP-9 were prepared. Gel contraction was significantly increased by addition of 0.8 mg/ml of MMP-9, while high concentrations of MMP-9 (>= 100 mg/ml) inhibited contraction. The addition of BB94 and TIMP-1 did not alter the inhibitory or stimulatory effect of MMP-9. Conclusions: Our data Suggest that MMP-9, independent of its proteolytic function, has a biphasic effect on SMC-mediated collagen gel contraction. Understanding the different roles of MMP-9 Should allow the development of better therapeutic strategies for restenotic vascular disease. (c) 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved. [less ▲]

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See detailCaractérisation par analyse d’images de l’angiogenèse sur des coupes histologiques
Le Maire, Sophie; Blacher, Silvia ULg; Labied, Soraya ULg et al

Conference (2005)

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See detailContrainte, limitation et atteinte à la propriété
Lecocq, Pascale ULg; Lewalle, Paul ULg

Book published by De Boeck & Larcier (2005)

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See detailLe modèle de consommation alimentaire en Wallonie
Lebailly, Philippe ULg

in Germain, Marc; Potelle, Jean-François (Eds.) La Wallonie à l’aube du XXIe siècle. Portrait d’un pays et de ses habitants (2005)

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See detailDiversity of cucurbit species cultivated in Côte d'Ivoire for Edible Seeds
Zoro Bi, I.; Koffi; Dje, Y. et al

in Cucurbit Genetics Cooperative, Report 2005 (2005), (28-29), 84-90

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See detailPoétique d'un engagement désenchanté : analyse de l'oeuvre romanesque de Pierre Mertens
Van Beveren, Julien ULg

Master's dissertation (2005)

Après une bio-bibliographie de Pierre Mertens, nous proposons une analyse de quatre de ses romans ("Les Bons Offices", "Les Eblouissements", "Terre d'Asile" et "Une Paix royale"), analyse orientée par la ... [more ▼]

Après une bio-bibliographie de Pierre Mertens, nous proposons une analyse de quatre de ses romans ("Les Bons Offices", "Les Eblouissements", "Terre d'Asile" et "Une Paix royale"), analyse orientée par la réponse à ces questions : y trouve-t-on des choix posés par l'auteur qui témoignent d'un engagement ? Si oui, de quel type d'engagement s'agit-il ? [less ▲]

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See detailAt Least Two Regions Of The Oncoprotein Tre2 Are Involved In Its Lack Of Gap Activity
Bizimungu, C.; Vandenbol, Micheline ULg

in Biochemical and Biophysical Research Communications (2005), 335(3),

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See detailMatériel d'artiste et pratiques d'atelier : les dessins de Lambert Lombard et de son entourage
Oger, Cécile ULg; Allart, Dominique ULg

in Balis, Arnout; Huvenne, Paul; Lambrechts, Jeanine (Eds.) et al Florissant. Bijdragen tot de kunstgeschiedenis der Nederlanden (15de-17de eeuw). Liber Amicorum Carl Van de Velde (2005)

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See detailPharmacological profile and therapeutic potential of BM-573, a combined thromboxane receptor antagonist and synthase inhibitor.
Ghuysen, Alexandre ULg; Dogné, Jean-Michel; Chiap, Patrice ULg et al

in Cardiovascular Drug Reviews (2005), 23(1), 1-14

BM-573 (N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea), a torsemide derivative, is a novel non-carboxylic dual TXA2 synthase inhibitor and receptor antagonist. The pharmacological ... [more ▼]

BM-573 (N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea), a torsemide derivative, is a novel non-carboxylic dual TXA2 synthase inhibitor and receptor antagonist. The pharmacological profile of the drug is characterized by a higher affinity for the thromboxane receptor than that of SQ-29548, one of the most powerful antagonists described to date, by a complete prevention of human platelet aggregation induced by arachidonic acid at a lower dose than either torsemide or sulotroban, and by a significantly prolonged closure time measured by the platelet function analyser (PFA-100). Moreover, at the concentrations of 1 and 10 microM, BM-573 completely prevented production of TXB2 by human platelets activated by 0.6 mM of arachidonic acid. BM-573 prevents rat fundus contraction induced by U-46619 but not by prostacyclin or other prostaglandins. Despite possessing a chemical structure very similar to that of a diuretic torsemide, BM-573 has no diuretic activity. BM-573 does not prolong bleeding time and, unlike some of the other sulfonylureas, has no effect on blood glucose levels. In vivo, BM-573 appears to have antiplatelet and antithrombotic activities since it reduced thrombus weight and prolonged the time to abdominal aorta occlusion induced by ferric chloride. BM-573 also relaxed rat aorta and guinea pig trachea precontracted with U-46619. In pigs, BM-573 completely antagonized pulmonary hypertensive effects of U-46619 and reduced the early phase of pulmonary hypertension in models of endotoxic shock and pulmonary embolism. Finally, BM-573 protected pigs from myocardial infarction induced by coronary thrombosis. These results suggest that BM-573 should be viewed as a promising therapeutic agent in the treatment of pulmonary hypertension and syndromes associated with platelet activation. [less ▲]

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See detailMagnitude representation in children: Its development and dysfunction
Noël, Marie-Pascale; Rousselle, Laurence ULg

in Campbell, Jamie (Ed.) Handbook of Mathematical Cognition (2005)

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See detailTryptophane-based biphenylsulfonamide matrix metalloproteinase inhibitors as tumor imaging agents
Oltenfreiter, R.; Staelens, L.; Labied, Soraya ULg et al

in Cancer Biotherapy & Radiopharmaceuticals (2005), 20(6), 639-47

Aim: As a part of our efforts to use small organic matrix metalloproteinase (MMP) inhibitors with improved characteristics for the diagnosis and treatment of different kinds of tumor tissues ... [more ▼]

Aim: As a part of our efforts to use small organic matrix metalloproteinase (MMP) inhibitors with improved characteristics for the diagnosis and treatment of different kinds of tumor tissues, biphenylsulfonamide analogues were synthesized. This study reports on the in vivo biodistribution of iodine-123-labeled biphenylsulfonide and analogues in A549 lung carcinoma inoculated into athymic mice and the evaluation of their suitability as imaging agents using a single photon emission computed tomography (SPECT) camera. Methods: The radioiodinated carboxylic and hydroxamic MMP inhibitors 2-(4′- [123I]iodobiphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionic acid (1′) and 2-(4′-[123I]iodobiphenyl-4- sulfonylamino)-3-(1H-indol-3-yl)-propionamide (2′) were synthesized by electrophilic aromatic substitution of the tributylstannyl derivatives. Planar gamma camera imaging was performed in nu/nu athymic mice bearing an A549 tumor using a Toshiba GCA-9300A/hg SPECT camera in planar mode equipped with a high-resolution, parallel-hole collimator. Results: Radiosynthesis of (1′) and (2′) resulted in radiochemical yields of 60 ± 5% (n ± 3) and 70 ± 5% (n = 6), respectively. Evaluation of tumors induced in athymic mice by the inoculation of non-small cell lung A549 carcinoma cells, showed a tumor uptake of 0.27–0.01 percent injected dose per gram (%ID/g) (3 hours–48 hours p.i.), a tumor-blood ratio of 0.7, a tumor-muscle ratio of 1.6, and a tumor-fat ratio of 0.5 at 24 hours (p.i.) for compound 1′. For compound 2′ a tumor uptake of 0.7–0.04 %ID/g (3 hours–48 hours p.i.), a postinjection tumor-blood ratio of 1.2, a tumor-muscle ratio of 3.2, and a tumor-fat ratio of 2.4 at 48 hours p.i. was observed. SPECT evaluation confirmed the results obtained from biodistribution. Conclusion: In vivo evaluation of these radioiodinated carboxylic and hydroxamic MMP inhibitor tracers revealed that they do not appear suitable as tumor-imaging agents. [less ▲]

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See detailSlavery Revisited through Vocal Kaleidoscopes: Polyphony in Novels by Fred D'Aguiar and Caryl Phillips
Ledent, Bénédicte ULg

in Misrahi-Barak (Ed.) Revisiting Slave Narratives / Le avatars contemporains des récits d'esclaves (2005)

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See detailDietary supplementation with chondroitin sulfate and glucosamine HCL does not slow down articular cartilage erosion in biglycan/fibromodulin deficient mice
Henrotin, Yves ULg; Deberg, M; Oliviera, M et al

in Osteoporosis International (2005), 16(Suppl 3), 105

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