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See detailOral and intravenous ibandronate in the management of postmenopausal osteoporosis: A comprehensive review
Reginster, Jean-Yves ULg

in Current Pharmaceutical Design (2005), 11(28), 3711-3728

Convenient strategies are needed for postmenopausal osteoporosis management. Current oral bisphosphonates are effective and generally well tolerated, but are hampered by strict dosing requirements. Less ... [more ▼]

Convenient strategies are needed for postmenopausal osteoporosis management. Current oral bisphosphonates are effective and generally well tolerated, but are hampered by strict dosing requirements. Less frequent dosing schedules are expected to improve adherence to therapy and hence outcomes. Ibandronate is a potent, nitrogen-containing bisphosphonate in ongoing clinical development exploring its potential to be administered less frequently than at weekly intervals. Uniquely, ibandronate can be administered either orally or as an intravenous (i.v.) injection, with a between-dose interval of >2 months. In postmenopausal women, oral ibandronate, when administered either daily or intermittently, has demonstrated robust antifracture efficacy at the spine (62% [p=0.0001] and 50% [p=0.0006] risk reduction versus placebo), accompanied by significant increases in bone mineral density (BMD) at the spine and hip, and suppression of bone turnover markers. Studies of intermittent i.v. ibandronate injections in postmenopausal women have shown dose-related BMD gains and bone turnover marker suppression comparable to those obtained after a similar duration of treatment with the proven effective oral ibandronate regimen. Furthermore, in a trial conducted in patients with corticosteroid-induced osteoporosis, intermittent i.v. ibandronate injections reduced vertebral fracture risk by 62% versus an active control (p=0.043). In all these trials, the oral and i.v. ibandronate regimens were well tolerated. Ongoing, large multinational clinical trials are investigating two intermittent ibandronate regimens: once-monthly oral and intermittent i.v. injections. These simple ibandronate regimens are expected to provide the optimal combination of efficacy, tolerability and patient convenience, leading to improved treatment adherence and thus, enhanced outcomes in postmenopausal osteoporosis. [less ▲]

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See detailStandard errors of solutions in large scale mixed models, application to linear and curvilinear effects of inbreeding on production traits.
Gengler, Nicolas ULg; Croquet, C.

in Journal of Dairy Science (2005), 88(Suppl. 1), 74-74

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See detailPlusieurs épidémies de fièvre hémorragique due au virus Ebola au Gabon, d'octobre 2001 à avril 2002
Nkoghe Mba, Dieudonne ULg; Formenty, P; Leroy, E M et al

in Bulletin de la Société de Pathologie Exotique (2005), 98(3), 224-229

Des épidémies de fièvre hémorragique virale à virus Ebola (FHVE) ont été rapportées de 1994 à 1996 dans la province de l’Ogooué Ivindo, une zone forestière située au Nord Est du Gabon. Chaque fois, les ... [more ▼]

Des épidémies de fièvre hémorragique virale à virus Ebola (FHVE) ont été rapportées de 1994 à 1996 dans la province de l’Ogooué Ivindo, une zone forestière située au Nord Est du Gabon. Chaque fois, les grands primates avaient été reconnus comme la source initiale de l’infection humaine. Fin novembre 2001 une nouvelle alerte est venue de cette province qui a rapidement était confirmée comme étant une épidémie de FHVE. La riposte a été organisée par le ministère de la santé publique avec l’aide d’une équipe internationale sous l’égide de l’OMS. Un système de surveillance active a été mis en place dans les trois districts touchés par l’épidémie (Zadié, Ivindo and Mpassa) afin d’organiser la détection des cas et le suivi de leur contacts. Une définition de cas a été adoptée, les cas suspects étaient isolés à l’hôpital, à domicile ou dans des lazarets, et des tests sérologiques étaient réalisés. Ces tests comportaient la détection de l’antigène ou des IgG spécifiques, et la RT-PCR. Un classement des cas était réalisé en fonction des résultats des tests biologiques et des données cliniques et épidémiologiques. Les sujets contacts étaient surveillés durant 21 jours. On a dénombré 65 cas dont 53 décès. Le premier cas humain, un chasseur, était décédé le 28 octobre 2001. L’épidémie s’est propagée grâce une transmission familiale et une contamination nosocomiale. Quatre foyers primaires distincts ont été mis en évidence ainsi qu’un cas isolé situé dans le Sud est du Gabon, à 580 km de l’épicentre, Les décès sont survenus dans un délai de 6 jours. Le dernier décès a été enregistré le 22 mars 2002 et la fin de l’épidémie déclarée le 6 mai 2002. L’épidémie s’est étendue au Congo voisin. Des morts inexpliquées d’animaux avaient été signalées dans les forêts environnantes dès le mois d’août 2001 : des grands primates et des céphalophes. Les prélèvements réalisés sur leurs carcasses confirmaient une épidémie animale concomitante. [less ▲]

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See detailProcessus de qualification du produit « viande bovine » veillant à valoriser les multiples fonctions de l’élevage
Stilmant, Didier; Stassart, Pierre M ULg; Jamar, Daniel

in Actes des Journées de Fourrage Actualité (2005)

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See detailEtiopathogenie et physiopathologie du diabete de type 2
Fery, Françoise; Paquot, Nicolas ULg

in Revue Médicale de Liège (2005), 60(5-6), 361-8

Etiopathogenesis of type 2 diabetes is complex and still partially unknown. Its etiology is determined by the interaction of genetic and environmental factors. The genetic contribution is important, but ... [more ▼]

Etiopathogenesis of type 2 diabetes is complex and still partially unknown. Its etiology is determined by the interaction of genetic and environmental factors. The genetic contribution is important, but has a polygenic origin. Obesity, especially when fat mass is preferably located in the abdomen, is the main predisposing factor for type 2 diabetes, and almost 80% of diabetic patients are overweight or obese. The diabetogenic effect of obesity is due to the capacity of excessive fat mass to induce or aggravate insulin resistance. Increasing lack of physical activity is also a contributing factor as it increases insulin resistance. As far as pathophysiology is concerned, the development of type 2 diabetes results from the coexistence of abnormalities of insulin secretion and insulin action. Insulin secretory dysfunction, whose underlying mechanism remains poorly understood, is characterized by a relative defect in circulating insulin levels of variable severity. Resistance to insulin action is located in the liver (increased hepatic glucose production), in the skeletal muscle (decreased muscular glucose uptake) and in the adipose tissue (exaggerated lipolysis with elevated plasma free fatty acids). Changes in life-style habits (weight reduction, regular physical activity) are able to prevent or delay the development of type 2 diabetes. [less ▲]

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See detailEffects of bioactive amphiphiles on model cell membranes
Deleu, Magali ULg

in 11th W. Mejbaum-Katzenellenbogen's Molecular Biology Seminar: amphiphiles and their aggregates in basic and applied science (2005)

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See detailProcessus de paternalité
Naziri, Despina ULg

Conference (2005)

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See detailLes ruses de l’illusion. Le “cas” Mallarmé
Durand, Pascal ULg

in Durand, Pascal; Dubois, J.; Winkin, Yves (Eds.) Le Symbolique et le Social. La réception internationale de la pensée de Pierre Bourdieu (2005)

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See detailLe juge constitutionnel comme législateur-cadre positif : les normes juridictionnelles relatives à la production et au contenu de normes législatives futures. Une analyse comparative en droit français, belge et allemand
Behrendt, Christian ULg

Doctoral thesis (2005)

The thesis studies the normative influence of the French, the German and the Belgian constitutional court on the production of legislative provisions by the three national parliaments.

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See detailReduced cell turnover in lymphocytic monkeys infected by human T-lymphotropic virus type 1.
Debacq, Christophe; Heraud, Jean-Michel; Asquith, Becca et al

in Oncogene (2005), 24(51), 7514-23

Understanding cell dynamics in animal models have implications for therapeutic strategies elaborated against leukemia in human. Quantification of the cell turnover in closely related primate systems is ... [more ▼]

Understanding cell dynamics in animal models have implications for therapeutic strategies elaborated against leukemia in human. Quantification of the cell turnover in closely related primate systems is particularly important for rare and aggressive forms of human cancers, such as adult T-cell leukemia. For this purpose, we have measured the death and proliferation rates of the CD4+ T lymphocyte population in squirrel monkeys (Saimiri sciureus) infected by human T-lymphotropic virus type 1 (HTLV-1). The kinetics of in vivo bromodeoxyuridine labeling revealed no modulation of the cell turnover in HTLV-1-infected monkeys with normal CD4 cell counts. In contrast, a substantial decrease in the proliferation rate of the CD4+ T population was observed in lymphocytic monkeys (e.g. characterized by excessive proportions of CD4+ T lymphocytes and by the presence of abnormal flower-like cells). Unexpectedly, onset of HTLV-associated leukemia thus occurs in the absence of increased CD4+ T-cell proliferation. This dynamics significantly differs from the generalized activation of the T-cell turnover induced by other primate lymphotropic viruses like HIV and SIV. [less ▲]

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See detailDecalactone production by Yarrowia lipolytica under increased O2 transfer rates
Aguedo, Mario ULg; Gomes, N.; Garcia, E. E. et al

in Biotechnology Letters (2005), 27(20), 1617-1621

Yarrowia lipolytica converts methyl ricinoleate to γ-decalactone, a high-value fruity aroma compound. The highest amount of 3-hydroxy-γ- decalactone produced by the yeast (263 mg∈l-1) occurred by ... [more ▼]

Yarrowia lipolytica converts methyl ricinoleate to γ-decalactone, a high-value fruity aroma compound. The highest amount of 3-hydroxy-γ- decalactone produced by the yeast (263 mg∈l-1) occurred by increasing the k L a up to 120 h-1 at atmospheric pressure; above it, its concentration decreased, suggesting a predominance of the activity of 3-hydroxyacyl-CoA dehydrogenase. Cultures were grown under high-pressure, i.e., under increased O2 solubility, but, although growth was accelerated, γ-decalactone production decreased. However, by applying 0.5 MPa during growth and biotransformation gave increased concentrations of dec-2-en-4-olide and dec-3-en-4-olide (70 mg∈l -1). © Springer 2005. [less ▲]

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See detailValproate activates bovine leukemia virus gene expression, triggers apoptosis, and induces leukemia/lymphoma regression in vivo.
Achachi, Amine; Florins, Arnaud-Francois ULg; Gillet, Nicolas ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2005), 102(29), 10309-14

Leukemogenic viruses like human T-lymphotropic virus and bovine leukemia virus (BLV) presumably persist in the host partly by latent integration of the provirus in a fraction of infected cells, leading to ... [more ▼]

Leukemogenic viruses like human T-lymphotropic virus and bovine leukemia virus (BLV) presumably persist in the host partly by latent integration of the provirus in a fraction of infected cells, leading to accumulative increase in the outgrowth of transformed cells. Furthermore, viral infection also correlates with a blockade of the apoptotic mechanisms concomitant with an apparent latency of the host cell. Conceptually, induction of viral or cellular gene expression could thus also be used as a therapeutic strategy against retroviral-associated leukemia. Here, we provide evidence that valproate, an inhibitor of deacetylases, activates BLV gene expression in transient transfection experiments and in short-term cultures of primary B-lymphocytes. In vivo, valproate injection into newly BLV-inoculated sheep did not abrogate primary infection. However, valproate treatment, in the absence of any other cytotoxic drug, was efficient for leukemia/lymphoma therapy in the sheep model leading to decreased lymphocyte numbers (respectively from 25.6, 35.7, and 46.5 x 10(3) cells per mm3 to 1.0, 10.6, and 24.3 x 10(3) cells per mm3 in three leukemic sheep) and tumor regression (from >700 cm3 to undetectable). The concept of a therapy that targets the expression of viral and cellular genes might be a promising treatment of adult T cell leukemia or tropical spastic paraparesis/human T-lymphotropic virus-associated myelopathy, diseases for which no satisfactory treatment exists so far. [less ▲]

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See detailInfluence of depth perception on performance and time evaluation in minimal access surgery
Blavier, Adelaïde ULg; Nyssen, Anne-Sophie ULg

Conference (2005)

This study aimed to evaluate the impact of depth perception on surgical tasks performance and time evaluation. 98 novice subjects performed a fine surgical task with a new laparoscopic technology (da ... [more ▼]

This study aimed to evaluate the impact of depth perception on surgical tasks performance and time evaluation. 98 novice subjects performed a fine surgical task with a new laparoscopic technology (da Vinci robotic system). They were divided in two groups, one using 3D view option and another using 2D view option. We measured time performance and asked subjects to evaluate their time performance. Our results showed subjects performed significantly quicker with robotic system in 3D than with robotic system in 2D. We obtained a significant interaction between time performance and time evaluation: in 2D condition, subjects accurately evaluated their time performance while in 3D condition, subjects evaluated their time performance as being longer than their real performance and even than real or evaluated performances of subjects in 2D condition. Our findings emphasize the role of 3D in improving performance and the contradictory feeling about time evaluation in 2D and 3D. [less ▲]

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See detailEffect of an oral antioxidant supplementation enriched in (n-3) fatty acids on erythrocyte membrane fluidity in horses.
De Moffarts, Brieuc; Portier, K.; Kirschvink, Nathalie et al

in Proceedings: Congrès de médecine et de chirurgie équine, Genève 2005 (2005)

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See detailA variational framework for nonlinear viscoelastic and viscoplastic models in finite deformation regime
Stainier, Laurent ULg; FANCELLO, E.; Ponthot, Jean-Philippe ULg

in MECOM 2005, , Mecanica Computational (2005)

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See detailCompte-rendu de l'ouvrage de A. Schlechter (éd.), ‚Die edel kunst der truckerey’. Ausgewëhlte Inkunabeln der Universitätsbibliothek Heidelberg
Adam, Renaud ULg

in Archives et Bibliothèques de Belgique = Archief en Bibliotheekwezen in Belgie (2005), 76

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See detailTALADAL expo : l'avenir de la planète est au bout de ta fourchette
Duquesne, Brigitte ULg; Flament, Bénédicte; Noël, Marie et al

Diverse speeche and writing (2005)

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See detailReduced chemical reaction mechanisms: experimental and HCCI modelling investigations of autoignition processes of iso-octane in internal combustion engines
Machrafi, Hatim ULg; Lombaert, K.; Cavadias, S. et al

in Fuel (2005), 84(18), 2330-2340

A semi-reduced (70 species, 210 reactions) and a skeletal (27 species, 29 reactions) chemical reaction mechanism for iso-octane are constructed from a semi-detailed iso-octane mechanism (84 species, 412 ... [more ▼]

A semi-reduced (70 species, 210 reactions) and a skeletal (27 species, 29 reactions) chemical reaction mechanism for iso-octane are constructed from a semi-detailed iso-octane mechanism (84 species, 412 reactions) of the Chalmers University of Technology in Sweden. The construction of the reduced mechanisms is performed by using reduction methods such as the quasi-steady-state assumption and the partial equilibrium assumption. The obtained reduced iso-octane mechanisms show, at the mentioned conditions, a perfect coherence with another more detailed iso-octane mechanism of ENSIC-CNRS (2411 reactions and 473 species) and the semi-detailed iso-octane mechanism of Chalmers. The validity of this mechanism with regard to the ignition delay is determined for several engine parameters adhering to HCCI conditions: inlet temperature (303-363 K), equivalence ratio (0.2-0.7) and compression ratio (10-16). The ignition delay is found to be decreased by an increase in the inlet temperature, a decrease in the equivalence ratio and an increase in the compression ratio. In order to validate the effects of the inlet temperature, compression ratio on the auto-ignition delay, experiments are performed on a CFR engine. A good agreement is obtained between experimental results and calculations. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

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See detailLa Belgique et les armes nucléaires
Dumoulin, André ULg; Michel, Quentin ULg

in Courrier Hebdomadaire du CRISP (2005), (1871-1872), 67

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