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See detailPerformances in hot and cold contrast of 32 camera heads assessed from planar views of the Picker's thyroid phantom.
Seret, Alain ULg

in European Journal of Nuclear Medicine and Molecular Imaging (2005), 32

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See detailThe Effect of Cyclodextrins on the Aqueous Solubility of a New Mmp Inhibitor: Phase Solubility, 1 H-Nmr Spectroscopy and Molecular Modeling Studies, Preparation and Stability Study of Nebulizable Solutions
Bertholet, Pascal; Guéders, Maud ULg; Dive, Georges ULg et al

in Journal of Pharmacy & Pharmaceutical Sciences : A Publication of the Canadian Society for Pharmaceutical Sciences (2005), 8(2), 164-175

PURPOSE: Ro 28-2653 (RO) is a synthetic inhibitor of matrix metalloproteinases (MMPs), which is potentially effective against bronchial remodeling. Given that this molecule has very poor aqueous ... [more ▼]

PURPOSE: Ro 28-2653 (RO) is a synthetic inhibitor of matrix metalloproteinases (MMPs), which is potentially effective against bronchial remodeling. Given that this molecule has very poor aqueous solubility, different cyclodextrins (CDs) have been tested to increase its solubility. The aim of this study was to prepare and to characterize inclusion complexes between RO and CDs, in order to develop nebulizable solutions. METHODS: The complex formation was investigated by phase solubility studies. (1)H-NMR spectroscopy and molecular modeling studies were carried out to elucidate the structure of the inclusion complex between RO and dimethyl-beta-CD (DIMEB). Nebulizable solutions of RO were developed with CDs and a stability study was performed over 9 months. RESULTS: The phase solubility studies showed that beta-CD and its derivatives form a 1:2 complex with RO, whereas gamma-CD includes RO with a 1:1 stoichiometry and a weak stability constant. T-ROESY spectra showed that DIMEB is able to complex two RO substituents (nitrophenyl and biphenyl groups) with preferential orientations, while molecular modeling demonstrated that the configurations observed with (1)H-NMR are energetically favorable, especially owing to H-bond formation between RO and DIMEB. Two CDs were selected to develop nebulizable solutions of RO and the stability study demonstrated that RO degradation in solution is strongly dependent on the concentration of the 1:2 inclusion complex. CONCLUSIONS: CDs are able to include RO and to improve its aqueous solubility. The beta-CD derivatives can be used to formulate nebulizable solutions of RO, the stability of which depends on the concentration of the 1:2 complex. [less ▲]

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See detailFinite element simulations of the swift effect
Duchene, Laurent ULg; El Houdaigui, Fouad; Habraken, Anne ULg

in Bariani, P. F. (Ed.) Proceedings of the ICTP 2005 International Conference on Technology of Plasticity (2005)

Numerical simulations of the experimental free-end torsion tests [1] of copper cylindrical bars were analysed in the present paper. The self-made Finite Element (FE) code Lagamine with polycrystal ... [more ▼]

Numerical simulations of the experimental free-end torsion tests [1] of copper cylindrical bars were analysed in the present paper. The self-made Finite Element (FE) code Lagamine with polycrystal plasticity models computed numerical prediction of the Swift effect, i.e. the lengthening of the cylinder during the torsion. The used constitutive law was coupled with two plastic crystal models, taking or not into account strain rate effect. Results such as axial strain and predicted textures were analysed. The ones obtained for shear strains lower than 1.0 were in good agreement with experiments; while, for shear strains larger than 1.0, the FE results were currently unfair. A research about remeshing is in progress to improve the accuracy of the results for large shear strains. [less ▲]

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See detailImage processing of 2D resistivity data for imaging faults
Nguyen, Frédéric ULg; Garambois, Stephane; Jongmans, Denis et al

in Journal of Applied Geophysics (2005), 57(4), 260-277

A methodology to locate automatically limits or boundaries between different geological bodies in 2D electrical tomography is proposed, using a crest line extraction process in gradient images, This ... [more ▼]

A methodology to locate automatically limits or boundaries between different geological bodies in 2D electrical tomography is proposed, using a crest line extraction process in gradient images, This method is applied on several synthetic models and on field data set acquired on three experimental sites during the European project PALEOSIS where trenches were dug. The results presented in this work are valid for electrical tomographies data collected with a Wenner-alpha array and computed with an 1(1) norm (blocky inversion) as optimization method, For the synthetic cases. three geometric contexts are modelled: a vertical and a dipping fault juxtaposing two different geological formations and a step-like structure. A superficial layer can cover each geological structure. In these three situations, the method locates the synthetic faults and layer boundaries, and determines fault displacement but with several limitations. The estimated fault positions correlate exactly with the synthetic ones if a conductive (or no superficial) layer overlies the studied structure. When a resistive layer with a thickness of 6 in covers the model, faults are positioned with a maximum error of 1 m. Moreover, when a resistive and/or a thick top layer is present, the resolution significantly decreases for the fault displacement estimation (error up to 150%). The tests with the synthetic models for surveys using the Wenner-alpha array indicate that the proposed methodology is best suited to vertical and horizontal contacts. Application of the methodology to real data sets shows that a lateral resistivity contrast of 1:5 1:10 leads to exact faults location. A fault contact with a resistivity contrast of 1:0.75 and overlaid by a resistive layer with a thickness or 1 m gives an error location ranging from 1 to 3 m. Moreover, no result is obtained for a contact with very low contrasts (similar to 1:0.85) overlaid by a resistive soil. The method shows poor results when vertical gradients are greater than horizontal ones. This kind of image processing technique should be systematically used for improving the objectiveness of tomography interpretation when looking for limits between geological objects. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailNeural mechanisms involved in the detection of our first name : A combined ERPs and PET study
Perrin, Fabien; Maquet, Pierre ULg; Peigneux, Philippe ULg et al

in Neuropsychologia (2005), 43(1), 12-19

In everyday social interactions, hearing our own first name captures our attention and gives rise to a sense of self-awareness, since it is one of the most socially self related stimulus. In the present ... [more ▼]

In everyday social interactions, hearing our own first name captures our attention and gives rise to a sense of self-awareness, since it is one of the most socially self related stimulus. In the present study, we combined ERPs and PET scan methods to explore the cerebral mechanisms underlying the detection of our own name. While categorical analyses of PET data failed to reveal significant results, we found that the amplitude of the P3 component, elicited when hearing one's own name, correlates with regional cerebral blood changes in right superior temporal sulcus, precuneus and medial prefrontal cortex. Additionally, the latter was more correlated to the P3 obtained for the subject's name compared to that obtained for other first names. These results suggest that the medial prefrontal cortex plays the most prominent role in self-processing. (C) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailEnchanting and enchanted dolphins. An analysis of human/dolphin encounters.
Servais, Véronique ULg

in Knight, John (Ed.) Animals in person. Cultural perspectives on human-aniaml intimacies (2005)

In occidental countries, the figure of the dolphin is permeated with love. Not only do people love dolphins, but the dolphins' anthropophilia belongs to their natural history as well : they rescue men at ... [more ▼]

In occidental countries, the figure of the dolphin is permeated with love. Not only do people love dolphins, but the dolphins' anthropophilia belongs to their natural history as well : they rescue men at sea, play in the bow waves of boats, and sometime develop enduring friendships with humans. People who have encountered dolphins in the open sea regularly speak about "falling in love" or feeling "pure love" from the dolphin ; others report telepathy, trance or mystic revelations. The emotions that people might experiment in an encounter with a dolphin are very powerful and embedded in numerous wondrous stories about dolphins. The paper begins with first hand accounts of persons who have encountered dolphins. A description of the practices of the encounter follows. Then I discuss some distinctive features of the human/dolphin communication (ethological signals, interactional patterns, the awareness of an alien consciousness) which might be associated with the emotions involved. The last part of the paper addresses the main representations of the dolphin in occidental countries (a messenger, a saviour, a healer). Those representations play a crucial role when the emotions or experiences are to be given a meaning. [less ▲]

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See detailThe homeobox protein MSX2 interacts with tax oncoproteins and represses their transactivation activity.
Twizere, Jean-Claude ULg; Lefebvre, Laurent; Collete, Delphine et al

in Journal of Biological Chemistry (2005), 280(33), 29804-11

Bovine leukemia virus (BLV) tax is an essential gene involved in the transcriptional activation of viral expression. Tax is also believed to be implicated in leukemogenesis because of its ability to ... [more ▼]

Bovine leukemia virus (BLV) tax is an essential gene involved in the transcriptional activation of viral expression. Tax is also believed to be implicated in leukemogenesis because of its ability to immortalize primary cells in vitro. To gain insight into the molecular pathways mediating the activities of this important gene, we identified cellular proteins interacting with Tax. By means of a two-hybrid approach, we show that Tax specifically interacts with MSX2, a general repressor of gene expression. GST pull-down experiments and co-immunoprecipitation assays further confirmed binding specificity. Furthermore, the N-terminal residues 1-79 of MSX2 are required for binding, whereas the C-terminal residues 201-267 of MSX2 do not play a critical role. Whereas the oncogenic potential of Tax in primary cells was only slightly affected by overexpression of MSX2, the other function of Tax, namely LTR-dependent transcriptional activation, was inhibited by MSX2 in human HeLa and bovine B-lymphoblastoid (BL3) cell lines. This MSX2 repression function can be counteracted by overexpression of transcription factors CREB2 and RAP74. The Tax/MSX2 interplay thus results in repression of viral transcriptional activation possibly acting as a regulatory feedback loop. Importantly, this viral gene silencing is not strictly associated with a concomitant loss of Tax oncogenicity as measured by its ability to immortalize primary cells. And interestingly, MSX2 also interacts with and inhibits the transactivation function of the related Tax1 protein encoded by the Human T-cell leukemia virus type 1 (HTLV-1). [less ▲]

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See detailThe State, the Market and Cultural Diversity
Martiniello, Marco ULg

in Al-Shahi, A.; Lawless, R. (Eds.) Middle East and North African Immigrants in Europe (2005)

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See detailApplication of space-time adaptive processing (STAP) to conformal arrays
Ries, Philippe; Lapierre, Fabian D.; Verly, Jacques ULg

Conference (2005)

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See detailEffect of long duration melatonin in an extended sleep opportunity protocol on core body temperature, TSH and HRV in humans
Middleton, B; Dijk, D-J; Rajaratnam, S et al

Poster (2005)

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See detailEvidence for a role of prolactin fragments in corpus luteum function
Ricken, A.; Merkwitz, C.; Struman, Ingrid ULg et al

in The society for the study of reproduction Annual meeeting, Quebec 2005 (2005)

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See detailUmberto Eco: "Die geheimnisvolle Flamme der Königin Loana". Ein Buchtipp
Küpper, Achim ULg

E-print/Working paper (2005)

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See detailPlasma progesterone and IGF-I levels at puberty in Italian Simmenthal and Friesian heifers with various genetic merit
Rossi, C.; Tondolo, A.; Massart, Serge et al

Conference (2005)

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See detailAbout the Rectilinear Keplerian Motion
Condurache, D.; Martinusi, Vladimir ULg

in Bulletin of the Polytechnic Institute of Jasi. Section Mathematics, Theoretical Mechanics, Physics = Buletinul Institutului Politehnic din Iaşi. Secţia Matematica, Mecanica Teoretica, Fizica (2005)

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See detailAnalysis of the sensivity of FEM predictions to numerical parameters in deep drawing simulations
Duchene, Laurent ULg; Habraken, Anne ULg

in European Journal of Mechanics A : Solids (2005), (24), 614-629

In this study, deep drawing finite element (FE) simulations are compared with experimental results. The steel grade, the geometry and the parameters of the experimental deep drawing processes are detailed ... [more ▼]

In this study, deep drawing finite element (FE) simulations are compared with experimental results. The steel grade, the geometry and the parameters of the experimental deep drawing processes are detailed in this paper. Particular attention is paid to numerical models. The main part of the article is dedicated to a broad sensitivity study. The influence of several numerical parameters on the predicted punch force and earing profile is analysed. A quadratic [Hill, R., 1948. A theory of the yielding and plastic flow of anisotropic metals. Proc. Roy. Soc. London Ser. A 193, 281–297] constitutive law is compared with more sophisticated micro-macro constitutive laws. The sensitivity of these laws to the initial data characterizing material behaviour is presented. A significant influence of the FE type and the number of FE layers is noticed. Finally, it also appears that friction parameters (penalty coefficient and Coulomb friction coefficient) have a significant influence on numerical results. The low anisotropy of the steel sheet increases the influence of several numerical parameters. That influence would not be observed with a highly anisotropic steel. [less ▲]

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See detailNumerical simulation and experimental validation of murine fracture healing
Geris, Liesbet ULg; Gerisch, A.; Maes, C. et al

in Proceedings of the European Conference on Mathematical and Theoretical Biology (2005)

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See detailA new automatic video multitracking system able to follow a large school
Delcourt, Johann ULg; Becco, Christophe ULg; Vandewalle, Nicolas ULg et al

in Noldus, L.P.P.J.; Grieco, F.; Loijens, L. W. S. (Eds.) et al Proceedings of Measuring Behavior 2005 (2005)

The study of shoaling behaviours is tackled by scientists by three approaches: the field, laboratory and computer modelling approach. The field studies are complicated and permit rarely an analysis of ... [more ▼]

The study of shoaling behaviours is tackled by scientists by three approaches: the field, laboratory and computer modelling approach. The field studies are complicated and permit rarely an analysis of individual positions. The third approach, consisting of development of mathematic models, is artificial. It requires a comparison with empiric results to validate and to determine the explications’ degree of each model. Thanks to the developments of digital imaging techniques, the laboratory studies on fish are able to measure the behavioural parameters with precision, impossible to realize with manual recording. Multitracking systems are rare and of recent development. These are insufficient to study the real size of shoals, often composed of hundreds of .shes. We have developed a new system of multitracking thanks to collaboration with the G.R.A.S.P. The G.R.A.S.P. has before realised other multitracking systems to follow some hundreds physical objects. Our video multitracking system is able to detect and to track more than a hundred unmarked fishes by gray scaling technique during some minutes. It permits an analysis as well at the group level as at the individual level. The multitraking program is able to attribute a number at each fish and to follow each one during the whole duration of the track. Our system permits the analysis of the movement of each individual, even if the trajectories of two fishes cross each other. It is possible thanks to the theoretical estimation of trajectory of each fish, compared with the real trajectory (analysis with feedback). The human eye is always necessary to detect the errors in identification but reediting is possible. However, if the fishes don’t move too rapidly, a rate of 25 images /s gives very good results, without too much visual expertise from the experimenter. If the fishes are too fast (i.e. escape response), it is better to use a high speed camera. [less ▲]

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