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See detailL'echinococcose alveolaire: une zoonose d'apparition recente en Wallonie
Wauters, Odile ULg; Honore, Charles ULg; Detry, Olivier ULg et al

in Revue Médicale de Liège (2005), 60(11), 867-74

Alveolar echinococcosis is a serious parasitic disease, leading to large hepatic lesions. It must be distinguished from cystic echinococcosis, or hydatic cyst, caused by Echinococcus granulosus. Early ... [more ▼]

Alveolar echinococcosis is a serious parasitic disease, leading to large hepatic lesions. It must be distinguished from cystic echinococcosis, or hydatic cyst, caused by Echinococcus granulosus. Early diagnosis may allow surgical removal of the lesions by segmental hepatectomy, the only curative treatment. Parasitostatic medical treatment with albendazole may promote stabilization of the disease. Until recently, Belgium was considered a country at very low risk for alveolar echinococcosis, as no human case was reported, despite up to 51% of fox infection in southern Belgium autopsy series. Recently four patients presented with alveolar echinococcosis at the University Hospital Center of Liege, leading to the fear of a possible alveolar echinococcosis endemy in southern Belgium. Two of these patients underwent curative hepatectomy, but the other two had already pulmonary metastases at diagnosis and received palliative albendazole therapy. This article presents these cases, and reviews the clinical features of this parasitic disease. [less ▲]

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See detailMechanical properties of highly porous PDLLA/Bioglass (R) composite foams as scaffolds for bone tissue engineering
Blaker, Jonny J.; Maquet, Véronique; Jérôme, Robert ULg et al

in Acta Biomaterialia (2005), 1(6), 643-652

This study developed highly porous degradable composites as potential scaffolds for bone tissue engineering. These scaffolds consisted of poly-d,l-lactic acid filled with 2 and 15 vol.% of 45S5 Bioglass® ... [more ▼]

This study developed highly porous degradable composites as potential scaffolds for bone tissue engineering. These scaffolds consisted of poly-d,l-lactic acid filled with 2 and 15 vol.% of 45S5 Bioglass® particles and were produced via thermally induced solid–liquid phase separation and subsequent solvent sublimation. The scaffolds had a bimodal and anisotropic pore structure, with tubular macro-pores of 100 μm in diameter, and with interconnected micro-pores of 10–50 μm in diameter. Quasi-static and thermal dynamic mechanical analysis carried out in compression along with thermogravimetric analysis was used to investigate the effect of Bioglass® on the properties of the foams. Quasi-static compression testing demonstrated mechanical anisotropy concomitant with the direction of the macro-pores. An analytical modelling approach was applied, which demonstrated that the presence of Bioglass® did not significantly alter the porous architecture of these foams and reflected the mechanical anisotropy which was congruent with the scanning electron microscopy investigation. This study found that the Ishai–Cohen and Gibson–Ashby models can be combined to predict the compressive modulus of the composite foams. The modulus and density of these complex foams are related by a power-law function with an exponent between 2 and 3. [less ▲]

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See detail« Excusez-moi, monsieur » : les alexandrins dans La Nausée de Sartre
Purnelle, Gérald ULg

in Poétique, revue de théorie et d'analyse littéraires (2005), 144

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See detailHeterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer disease
Anchisi, D.; Borroni, B.; Franceschi, M. et al

in Archives of Neurology (2005), 62(11), 1728-1733

Background: Subjects with amnesic mild cognitive impairment (aMCI) may include patients at high risk for progression to Alzheimer disease (AD) and a population with different underlying pathologic ... [more ▼]

Background: Subjects with amnesic mild cognitive impairment (aMCI) may include patients at high risk for progression to Alzheimer disease (AD) and a population with different underlying pathologic conditions. Objective: To evaluate the potential roles of positron emission tomography with fluodeoxyglucose F 18 ((18)FDG-PET) and memory scores in identifying subjects with aMCI and in predicting progression to dementia. Design, Setting, and Patients: Sixty-seven patients at European centers for neurologic and AD care who were diagnosed as having aMCI each underwent an extensive clinical and neuropsychological examination and an (18)FDG-PET study. Forty-eight subjects were followed up periodically for at least I year, and progression to dementia was evaluated. Main Outcome Measures: Brain glucose metabolism and memory scores. Results: Fourteen subjects with aMCI who converted to AD within 1 year showed bilateral hypometabolism in the inferior parietal, posterior cingulate, and medial temporal cortex. Subjects with "stable" aMCI presented with hypometabolism in the dorsolateral frontal cortex. The severity of memory impairment, as evaluated by the California Verbal Learning Test-Long Delay Free Recall scores, correlated with the following brain metabolic patterns: scores less than 7 were associated with a typical (18)FDG-PET AD pattern, and scores of 7 or higher were associated with hypornetabolism in the dorsolateral frontal cortex and no progression to AD. Conclusion: These data provide evidence for clinical and functional heterogeneity among subjects with aMCI and suggest that (18)FDG-PET findings combined with memory scores may be useful in predicting short-term conversion to AD. [less ▲]

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See detailImaging of liquid distribution in reactive distillation packings with a new high-energy x-ray tomograph
Toye, Dominique ULg; Crine, Michel ULg; Marchot, Pierre ULg

in Measurement Science & Technology (2005), 16(11), 2213-2220

We describe a new, high-energy (420 kV), large-scale (0.45 m in diameter, 4 m in height) x-ray tomograph developed to investigate gas and liquid flow through fixed bed like absorption, distillation and ... [more ▼]

We describe a new, high-energy (420 kV), large-scale (0.45 m in diameter, 4 m in height) x-ray tomograph developed to investigate gas and liquid flow through fixed bed like absorption, distillation and reactive distillation columns. The first results obtained with this set-up on test objects (physical phantoms), such as a cylindrical container filled with water or a large diameter structured metallic packing, validate the technique as a quantitative tool for geometrical measurements. Very detailed two-dimensional (21)) and three-dimensional (3D) images of a 0.09 m diameter KATAPAK-SP 12, a reactive distillation packing, are presented. Quantitative information relative to liquid hold-up distribution may be obtained from tomographic imaging performed on an irrigated column packed with this element. [less ▲]

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See detailOxytocin receptor pattern of expression in primary lung cancer and in normal human lung
Pequeux, Christel ULg; Breton, C.; Hagelstein, M. T. et al

in Lung Cancer (2005), 50(2), 177-188

In order to assess if oxytocin- and vasopressin-induced mitogenic effects detected on small-cell lung carcinoma (SCLC) cell lines could be transposed on primary SCLC, the aim of the present work was to ... [more ▼]

In order to assess if oxytocin- and vasopressin-induced mitogenic effects detected on small-cell lung carcinoma (SCLC) cell lines could be transposed on primary SCLC, the aim of the present work was to identify mediators of these mitogenic actions on primary tumours samples. This was addressed on normal human lung tissue, on SCLC and on non-SCLC (NSCLC). Herein, we observe, in normal human lung, that OTR is colocalized with vascular endothelial cells of the lung and is not expressed by lung cells of epithelial nature. We detected mRNA amplification of V1aR, V2R and of a V2R variant. We observed that 86% of SCLC biopsies analyzed expressed at least the OTR and that 71% expressed the OTR, the V1aR and the V2R altogether. Comparatively, 50% of NSCLC biopsies tested expressed at least the OTR and 32% expressed the OTR, the V1aR and the V2R altogether. The occurrence of the V1bR/V3R is of 28 and 18% for SCLC and NSCLC, respectively. Nevertheless, for the SCLC biopsies analyzed in this study, V1bR/V3R expression correlates, in all cases, with the expression of all the other neurohypophysial peptide receptors. Our results suggest that neurohypophysial peptide antagonists may offer promise as a potential new therapeutic modality for the treatment of lung cancer expressing at least one of the neurhypophysial peptide receptor subtypes. (c) 2005 Elsevier Ireland Ltd. All rights reserved. [less ▲]

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See detailPoly(ethylene-co-vinyl acetate)/clay nanocomposites: Effect of clay nature and organic modifiers on morphology, mechanical and thermal properties
Peeterbroeck, Sophie; Alexandre, Michaël ULg; Jérôme, Robert ULg et al

in Polymer Degradation & Stability (2005), 90(2), 288-294

Nanocomposites based on an ethylene vinyl acetate copolymer (27 wt% vinyl acetate) and various (organo-modified) clays have been prepared by melt blending and their morphology, tensile and thermal ... [more ▼]

Nanocomposites based on an ethylene vinyl acetate copolymer (27 wt% vinyl acetate) and various (organo-modified) clays have been prepared by melt blending and their morphology, tensile and thermal degradation properties have been evaluated. Special attention has been paid to the influence of the clay nature and origin (montmorillonite or fluoromica) as well as on the nature of the ammonium cation organic modifier. It has been shown that nanostructure and tensile properties mainly depend on the nature of the organic modifier while the delay in thermal volatilisation of EVA during thermo-oxidation is mainly driven by the nature of the clay (mainly its aspect ratio), with no significant influence of the nanostructure of the nature of the organic modifier. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

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See detailPrecambrian geodynamics and ore formation: The Fennoscandian Shield
Weihed, Pär; Arndt, Nicholas; Billström, Kjell et al

in Ore Geology Reviews (2005), 27(1-4), 273-322

Compared with present-day global plate tectonics, Archaean and Palaeoproterozoic plate tectonics may have involved faster moving, hotter plates that accumulated less sediment and contained a thinner ... [more ▼]

Compared with present-day global plate tectonics, Archaean and Palaeoproterozoic plate tectonics may have involved faster moving, hotter plates that accumulated less sediment and contained a thinner section of lithospheric mantle. This scenario also fits with the complex geodynamic evolution of the Fennoscandian Shield from 2.06 to 1.78 Ga when rapid accretion of island arcs and several microcontinent-continent collisions in a complex array of orogens was manifested in short-lived but intense orogenies involving voluminous magmatism. With a few exceptions, all major ore deposits formed in specific tectonic settings between 2.06 and 1.78 Ga and thus a strong geodynamic control oil ore deposit formation is suggested. All orogenic gold deposits formed syn- to post-peak metamorphism and their timing reflects the orogenic younging of the shield towards the SW and west. Most orogenic gold deposits formed during periods of crustal shortening with peaks at 2.72 to 2.67, 1.90 to 1.86 and 1.85 to 1.79 Ga. The ca. 2.5 to 2.4 Ga Ni-Cu PGE deposits formed both as part of layered igneous complexes and associated with mafic volcanism, in basins formed during rifling of the Archaean craton at ca. 2.5 to 2.4 Ga. Svecokarelian ca. 1.89 to 1.88 Ga Ni-Cu deposits are related to mafic-ultramafic rocks intruded along linear belts at the accretionary margins of microcratons. All major VMS deposits in the Fennoscandian Shield formed between 1.97 and 1.88 Ga, in extensional settings, prior to basin inversion and accretion. The oldest "Cyprus-type" deposits were obducted onto the Archaean continent during the onset of convergence. The Pyhasalmi VMS deposits formed at 1.93 to 1.91 Ga in primitive, bimodal arc complexes during extension of the arc. In contrast, the Skellefte VMS deposits are 20 to 30 million years younger and formed in a strongly extensional intra-arc region that developed on continental or mature arc crust. Deposits in the Bergslagen-Uusimaa belt are similar in age to the Skellefte deposits and formed in a microcraton that collided with the Karelian craton at ca. 1.88 to 1.87 Ga. The Bergslagen-Uusimaa belt is interpreted as an intra-continental, or continental margin back-arc, extensional region developed on older continental crust. Iron oxide-copper-gold (IOCG) deposits are diverse in style. At least the oldest mineralizing stages, at ca. 1.88 Ga, are coeval with calc-alkaline to monzonitic magmatism and coeval and possibly cogenetic subaerial volcanism more akin to continental arcs or to magmatic arcs inboard of the active subduction zone. Younger mineralization of similar style took place when S-type magmatism occurred at ca. 1.80 to 1.77 Ga during cratonization distal to the active N-S-trending subduction zone in the west. Possibly, interaction of magmatic fluids with evaporitic sequences in older rift sequences was important for ore formation. Finally, the large volumes of anorthositic magmas that characterize the Sveconorwegian Orogeny formed a major concentration of Ti in the SW part of the Sveconorwegian orogenic belt under granulite facies conditions, about 40 million years after the last regional deformation of the Sveconorwegian Orogeny, between ca. 930 and 920 Ma. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailPrevalence des differentes especes de Candida au niveau vaginal dans la region Liegeoise
Senterre, J. M.; Carpentier, Martine ULg; Foidart, Jean-Michel ULg

in Revue Médicale de Liège (2005), 60(11), 882-4

We calculated the prevalences of different yeast species isolated from more than 20,000 vulvovaginal specimens carried out at the CHR hospital in Liege. To assess the value of the observed relative ... [more ▼]

We calculated the prevalences of different yeast species isolated from more than 20,000 vulvovaginal specimens carried out at the CHR hospital in Liege. To assess the value of the observed relative frequencies, the culture results of 149 samples were confronted with those of a real-time PCR technique of fungal identification. With a prevalence close to 90%, Candida albicans remains the largely dominant species. In contrast with other teams, we observed no increase of the prevalences of Candida non-albicans species. [less ▲]

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See detailA multicenter collaborative study to measure the prevalence of pituitary disease : methodology and preliminary findings
Tikhomirova, M.; Daly, Adrian ULg; Petrossians, Patrick ULg et al

in 15th Meeting of the Belgian Endocrine Society : Bruxelles, 26 novembre 2005 (2005, November)

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See detailDaily somatic cellular counts variations in milk of healthy cows
Pluvinage, Pascal; Hanzen, Christian ULg

in Mastitis in dairy production (2005, November)

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See detailSubchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes
Sanchez, Christelle ULg; Deberg, Michelle ULg; Piccardi, Nathalie et al

in Osteoarthritis and Cartilage (2005), 13(11), 988-997

Objective: To determine the influence of osteoarthritic (OA) phenotype of subchondral osteoblasts on the phenotype of human chondrocytes Methods: Human chondrocytes were isolated from CA cartilage and ... [more ▼]

Objective: To determine the influence of osteoarthritic (OA) phenotype of subchondral osteoblasts on the phenotype of human chondrocytes Methods: Human chondrocytes were isolated from CA cartilage and cultured in alginate beads for 4 or 10 days in the absence or in the presence of osteoblasts in monolayer. The osteoblasts were either isolated from non-sclerotic (N) or sclerotic (SC) zones of human subchondral bone. Before co-culture, osteoblasts were incubated for 72 h with or without 1.7 ng/ml interleukin (IL)-1 beta, 100 ng/ml IL-6 with its soluble receptor (50 ng/ml) or 10 ng/ml oncostatin M. SOX9, type I, II and X collagen (COL1, COL2, COL10), osteoblasts-stimulating factor (OSF)-1, bone alkaline phosphatase (ALP), parathyroid hormone related peptide (PTHrP) and its receptor (PTH-R) messenger RNA (mRNA) levels in chondrocytes were quantified by real-time polymerase chain reaction. Results: In comparison with chondrocytes cultured alone in alginate beads, chondrocytes after 4 days in co-culture with N or SC osteoblasts expressed significantly less SOX9 and COL2 mRNA. The decrease of SOX9 and COL2 gene expression was significantly more pronounced in the presence of SC than in the presence of N osteoblasts (P < 0.001). OSF-1 mRNA level in chondrocyte was increased by both N and SC osteoblasts, but to a larger extent by SC osteoblasts (P < 0.001). PTHrP expression in chondrocytes was 21 -fold increased by N osteoblasts but four-fold inhibited by SC osteoblasts. PTHrP secretion was also increased by N but reduced by SC osteoblasts. SC, but not N osteoblasts, induced a significant decrease of PTH-R gene expression in chondrocyte. In our experimental conditions, chondrocytes did not express COL1, COL10 or ALP, even after 10 days of co-culture with osteoblasts. Conclusions: In co-culture, SC subchondral osteoblasts decrease SOX9, COL2, PTHrP and PTH-R gene expression by chondrocytes but increase that of OSF-1. These findings suggest that SC osteoblasts could initiate chondrocyte phenotype shift towards hypertrophic differentiation and subsequently further matrix mineralization. (c) 2005 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved. [less ▲]

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See detailA method based on multiple adaptive windows to improve the determination of disparity maps
Demoulin, Cédric; Van Droogenbroeck, Marc ULg

in ProRISC/IEEE Workshop on Circuit, Systems and Signal Processing (2005, November)

The correspondence problem is one of main topics in stereo vision that, despites being studied for many years, is still in progress. In this paper, we present a new method that computes the disparity map ... [more ▼]

The correspondence problem is one of main topics in stereo vision that, despites being studied for many years, is still in progress. In this paper, we present a new method that computes the disparity map. Our method is local (i.e. only information gathered in the close neighborhood is used) and is based on image statistics. More specifically it combines multiple adaptive windows and local statistical measures in order to optimize the quality of the computation of disparity maps. As the size of windows is critical for local methods, we propose an algorithm that modifies the size of windows surrounding the pixel of interest to capture enough information in regions with low texture energy. This process is based on statistical measures (mean and horizontal/vertical average deviation) taken in the windows of the original stereo images. In the last section we show that our method performs very well compared to other existing local methods. [less ▲]

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See detailBenefits of strength and plyometric training on athletic performance in preadolescent soccer players
Bury, Thierry ULg

in Abstract book of BASEM Congress (2005, November)

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See detailLa tremblante du mouton influence-t-elle le système immunitaire lors d’une réponse vis-à-vis d’un antigène
Defaweux, Valérie ULg; Dorban, G.; Demonceau, C. et al

Conference (2005, November)

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See detailPrise en charge de la douleur chronique
Martin, Didier ULg

Scientific conference (2005, November)

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See detailSpace Weather influence on satellite based navigation and precise positioning
Warnant, René ULg; Lejeune, Sandrine; Bavier, Michaël

Conference (2005, November)

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See detailComputed tomographic pulmonary angiography and prognostic significance in patients with acute pulmonary embolism
Ghuysen, Alexandre ULg; Ghaye, Benoît ULg; Willems, V. et al

in Thorax (2005), 60(11), 956-961

Background: Patients with acute pulmonary embolism (APE) present with a broad spectrum of prognoses. Computed tomographic pulmonary angiography (CTPA) has progressively been established as a first line ... [more ▼]

Background: Patients with acute pulmonary embolism (APE) present with a broad spectrum of prognoses. Computed tomographic pulmonary angiography (CTPA) has progressively been established as a first line test in the APE diagnostic algorithm, but estimation of short term prognosis by this method remains to be explored. Methods: Eighty two patients admitted with APE were divided into three groups according to their clinical presentation: pulmonary infarction (n=21), prominent dyspnoea (n=29), and circulatory failure (n=32). CTPA studies included assessment of both pulmonary obstruction index and right heart overload. Haemodynamic evaluation was based on systolic aortic blood pressure, heart rate, and systolic pulmonary arterial pressure obtained non-invasively by echocardiography at the time of diagnosis of pulmonary embolism. Results: The mortality rate was 0%, 13.8% and 25% in the three groups, respectively. Neither the pulmonary obstruction index nor the pulmonary artery pressure could predict patient outcome. In contrast, a significant correlation with mortality was found using the systolic blood pressure (p<0.001) and heart rate (p<0.05), as well as from imaging parameters including right to left ventricle minor axis ratio (p<0.005), proximal superior vena cava diameter (p<0.001), azygos vein diameter (p<0.001), and presence of contrast regurgitation into the inferior vena cava (p=0.001). Analysis from logistic regression aimed at testing for mortality prediction revealed true reclassification of 89% using radiological variables. Conclusion: These results suggest that CTPA quantification of right ventricular strain is an accurate predictor of in-hospital death related to pulmonary embolism. [less ▲]

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See detailLinear and nonlinear analyses of convective instabilities in evaporating liquid layers
Dauby, Pierre ULg; Dondlinger, Mireille; Marjerit, Jonathan et al

in Bulletin of the American Physical Society, Vol. 45, n°9 (2005, November)

The present work consists in a theoretical study of Rayleigh- B'enard-Marangoni instabilities in an evaporating horizontal liquid layer which is surmounted by a mixture of its vapour and an inert gas. The ... [more ▼]

The present work consists in a theoretical study of Rayleigh- B'enard-Marangoni instabilities in an evaporating horizontal liquid layer which is surmounted by a mixture of its vapour and an inert gas. The fluid and the gas mixture form a 2-layer system but simplified models can be built to analyse the behaviour of the system. In particular, a 1-layer model can be deduced by introducing a generalized Biot number. In the so- called 1.5-layer approximation, the behaviour of the gas is simplified by only keeping the linear equation of vapour diffusion. In the linear study of thermoconvective instabilities, both simplified models are shown to be in good agreement with the complete 2-layer system. For the non linear approach, only the simplified models are considered. A Galerkin-Eckhaus method is used to deduce amplitude equations for the weakly nonlinear analysis of the problem. The stability domains for the rolls, squares and hexagonal patterns emerging above threshold are determined. Both water and ethanol are used as fluids, while the inert gas is assumed to be air. [less ▲]

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