Residual cognitive function in comatose, vegetative and minimally conscious statesLaureys, Steven ; ; Schnakers, Caroline et alin Current Opinion In Neurology (2005), 18(6), 726-733 Purpose of review The clinical evaluation of cognition in non-communicative severely brain-damaged patients is inherently difficult. In addition to novel behavioural 'consciousness-scales', the role of ... [more ▼] Purpose of review The clinical evaluation of cognition in non-communicative severely brain-damaged patients is inherently difficult. In addition to novel behavioural 'consciousness-scales', the role of para-clinical markers of consciousness, such as event related potentials and functional neuroimaging is reviewed. Recent findings New behavioural scales for vegetative and minimally conscious patients have been shown to reduce diagnostic error but regrettably remain underused in clinical routine. Electrophysiological studies have confirmed their role in estimating outcome and possibly cognition. Several recent functional neuroimaging studies have shown residual cortical function in undeniably vegetative patients. This cortical activation, however, seems limited to primary 'low-level' areas and does not imply 'higher-order' integration, considered necessary for conscious perception. Minimally conscious patients show large-scale high-order cerebral activation, apparently dependent upon the emotional relevance of the stimulation. Summary Careful clinical assessment of putative 'conscious behaviour' in vegetative and minimally conscious patients is the first requirement for their proper diagnosis and management. Complementary functional neuroimaging and electrophysiological studies will have a major impact on future clinical decision making and may guide selective therapeutic options. At present, more experimental evidence and the elucidation of methodological and ethical controversies are awaited prior to their routine clinical use. [less ▲] Detailed reference viewed: 16 (2 ULg) Integration de la pharmacogenetique dans la pratique medicaleDideberg, Vinciane ; Bours, Vincent ![]() in Revue Médicale de Liège (2005), 60(12), 918-22 Today, the initiation of any medical treatment still raises questions about its efficacy and safety. Indeed, therapeutic responses vary over time and between individuals and are influenced by age, sex ... [more ▼] Today, the initiation of any medical treatment still raises questions about its efficacy and safety. Indeed, therapeutic responses vary over time and between individuals and are influenced by age, sex, other treatments and the pathology itself. Genetic factors are thought to be responsible for 20 to 95% of these individual variations. Recent advances in biotechnology, molecular genetics and genomics allow a better understanding of drug metabolism and action. Pharmacogenetics, compiling phenotypic and genotypic data, may lead to a more personalized treatment. To allow a better approach of pharmacogenetics and pharmacogenomics, we will define these two terms and describe their actual and future clinical application. [less ▲] Detailed reference viewed: 29 (0 ULg) Feeding ecology of five commercial shark species of the Celtic Sea through stable isotope and trace metal analysis; Bouquegneau, Jean-Marie ; Das, Krishna ![]() in Marine Environmental Research (2005), 60(5), In order to trace their feeding habits, stable carbon and nitrogen isotope ratios (delta(15)N and delta(13)C), as well as trace metal concentrations (Zn, Cd, Fe, Cu, Se and Hg) were analysed in the ... [more ▼] In order to trace their feeding habits, stable carbon and nitrogen isotope ratios (delta(15)N and delta(13)C), as well as trace metal concentrations (Zn, Cd, Fe, Cu, Se and Hg) were analysed in the tissues of five commercial shark species from the Celtic Sea: the tope shark Galeorhinus galeus, the black-mouthed catshark Galeus melastomus, the starry smooth hound Mustelus asterias, the spiny dogfish Squalus acanthias and the lesser-spotted dogfish Scyliorhinus canicula. Our results were compared to previously described stomach contents and isotopic composition of potential preys. Isotopic ratio delta(15)N suggested that tope sharks fed at a higher trophic level (16.7 parts per thousand in the muscle) than the other species, reflecting its piscivorous diet. The lower values of spiny dogfish (11.6 parts per thousand in the muscle) might be explained, amongst other things, by either its migratory behaviour or its preference for preys from lower trophic levels. Cd and Hg were correlated with isotopic ratios delta(13)C and delta(15)N, and were shown to be diet-related whereas Zn, Fe and Cu seemed much more linked to species-specific metabolism. Although this multidisciplinary approach is revealed as a useful tool for the study of shark ecology, the lack of known trophic fractionation suggests that isotopic data be compared to traditional diet analyses. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲] Detailed reference viewed: 87 (19 ULg) Murine bone marrow stromal cells sustain in vivo the survival of hematopoietic stem cells and the granulopoietic differentiation of more mature progenitors; Humblet, Chantal ; Belaid, Zakia et alin Stem Cells (2005), 23(10, Nov-Dec), 1626-1633 The study of the human hematopoietic system would be facilitated by availability of a relevant animal model. Because the medullar microenvironment is made of different types of cells, interactions between ... [more ▼] The study of the human hematopoietic system would be facilitated by availability of a relevant animal model. Because the medullar microenvironment is made of different types of cells, interactions between hematopoietic cells and stromal cells are difficult to analyze in detail. As an approach for establishing an in vivo model to dissect these interactions, we grafted murine bone marrow fibroblastic cells (MS-5 cell line) with hematopoietic cells into the kidney capsule of syngenic mice. To identify the origin of cells present in the graft, we used green fluorescent protein-stable transfected MS-5 cells for the transplantation. To analyze the evolution of stromal cells and identify hematopoietic cells able to develop in these conditions, we performed morphology, histochemistry, and immunohistology on tissue sections at different times after transplantation. When injected alone, MS-5 cells differentiate into adipocytes. When injected with a bone marrow suspension or with isolated CD45(+) cells (leukocytes), the stromal cells keep their fibroblastic morphology and their alkaline phosphatase expression and sustain granulopoiesis. When injected with hematopoietic stem cells called c-kit(+)Sca-1(+)Lin(-) suspension, clusters of hematopoietic cells are also observed: They do not present any granulopoietic activity and do not belong to B or T population nor to erythroid lineage. They are quiescent, induce bone marrow recovery and survival of lethally irradiated recipients, are able to form macroscopic colonies in the spleen, and are able to form very few colonies in vitro, suggesting that they are hematopoietic stem cells. In conclusion, our results show that reticular fibroblastic stromal cells MS-5 sustain the survival of stem cells and are not able to induce their differentiation. However, they can control differentiation, proliferation, and/or survival of hematopoietic cells engaged in myeloid lineage. STEM CELLS 2005;23:1626-1633. [less ▲] Detailed reference viewed: 22 (4 ULg) Mise en place d’une stratégie de communication et de contrôle de la qualité écologique et sociale fondée sur l’étiquetage, les indications de qualité et la force de marque pour les vêtements, les articles de sport et les voitures; Van Caillie, Didier ![]() Report (2005) This report describes which are the practices implemented by firms in the furnishment industry, in the auto industry and in the sport industry to signal and to control the external Ecological and Societal ... [more ▼] This report describes which are the practices implemented by firms in the furnishment industry, in the auto industry and in the sport industry to signal and to control the external Ecological and Societal Quality of their products. [less ▲] Detailed reference viewed: 40 (1 ULg) Influence of emotion on memory for temporal informationD'Argembeau, Arnaud ; Van der Linden, Martial ![]() in Emotion (Washington, D.C.) (2005), 5(4), 503-507 Contextual information. such as color and spatial location, has been found to be better remembered for emotional than for neutral items. The current study examined whether the influence of emotion extends ... [more ▼] Contextual information. such as color and spatial location, has been found to be better remembered for emotional than for neutral items. The current study examined whether the influence of emotion extends to memory for another fundamental feature of episodic memory: temporal information. Results from a list-discrimination paradigm showed that (a) item memory was enhanced for both negative and positive pictures compared with neutral ones and was better for negative than for positive pictures and (b) temporal information was better remembered for negative than for positive and neutral pictures, whereas positive and neutral pictures did not differ from each other. These findings are discussed in relation to the processes involved in memory for temporal information. [less ▲] Detailed reference viewed: 92 (4 ULg) Conséquences de la chirurgie de transposition du muscle grand dorsalForthomme, Bénédicte ; ; Grandjean, François-Xavier et alin Abstract book de la 5ème Journée Belge d’Isocinétisme du GIBL (2005, December) Detailed reference viewed: 21 (1 ULg) The Hungarian Competition Council clears a 9 years’ exclusive agreement on the basis of Art. 81.3 EC (Rába/Integris)Defossez, Alexandre ; in e-competitions bulletin (2005) Detailed reference viewed: 12 (0 ULg) Intérêt de l’exercice excentrique dans le traitement de l’épicondylite chroniqueCroisier, Jean-Louis ; Foidart-Dessalle, Marguerite ; Crielaard, Jean-Michel et alin Abstract book de la 5ème Journée Belge d’Isocinétisme du GIBL (2005, December) Detailed reference viewed: 66 (1 ULg) Mise au point d'un biopesticide à base de levure pour lutter contre les maladies de conservation des pommesJijakli, Haissam ![]() Conference (2005, December) Detailed reference viewed: 8 (1 ULg) PMTIC - Plan Mobilisateur des Technolgies de l'Information et de la CommunicationGeorges, François ; Van de Poël, Jean-François ; Verpoorten, Ingrid et alReport (2005) Projet de recherche-action visant la formation des demandeurs d'emploi en Région Wallonne. Detailed reference viewed: 5 (2 ULg) The use of mathematical symbolism in problem solving : an empirical study carried out in grade one in the French Community of BelgiumFagnant, Annick ![]() in European Journal of Psychology of Education (2005), XX(4), 355-367 This article relates to an empirical study based on the use of mathematical symbolism in problem solving. Twenty-five pupils were interviewed individually at the end of grade one; each of them was asked ... [more ▼] This article relates to an empirical study based on the use of mathematical symbolism in problem solving. Twenty-five pupils were interviewed individually at the end of grade one; each of them was asked to solve and symbolize 14 different problems. In their classical curriculum, these pupils have received a traditional education based on a "top-down" approach (an approach that is still applied within the French Community of Belgium): conventional symbols are presented to the pupils immediately with an explanation of what they represent and how they should be used. Teaching then focuses on calculation techniques (considered as a pre-requisite for solving problems). The results presented here show the abilities (and difficulties) demonstrated by the children in making connections between the conventional symbolism taught in class and the informal approaches they develop when faced with the problems that arc, put to them. The limits of the "top-down" approach are then discussed as opposed to the more innovative "bottom-up" type approaches, such as those developed by supporters of Realistic Mathematics Educations in particular. [less ▲] Detailed reference viewed: 17 (1 ULg) Vom mittelalterlichen Zorn zur modernen Verlegenheit Über "Fehltritt", Schamgefühl und "Manieren"Pontzen, Alexandra ; Möller, Robert ![]() in Literaturkritik.de (2005) Detailed reference viewed: 30 (3 ULg) Hepatitis C virus genotype 5 in southern Belgium: Epidemiological characteristics and response to therapyDelwaide, Jean ; Gerard, Christiane ; Reenaers, Catherine et alin Digestive Diseases & Sciences (2005), 50(12), 2348-2351 Data are scarce on patients infected with hepatitis C virus of genotype 5, due to the low prevalence of this genotype around the world. To better define the characteristics of these patients, we reviewed ... [more ▼] Data are scarce on patients infected with hepatitis C virus of genotype 5, due to the low prevalence of this genotype around the world. To better define the characteristics of these patients, we reviewed the files of 16 genotype 5 patients. Mean age was 38 +/- 14. All patients were of European origin. Most of them (75%) had been contaminated by transfusion within a short time period (between 1980 and 1991). There were no intravenous drug addicts. Seven patients received treatment. One patient did not respond to interferon (IFN) monotherapy. Of four patients treated with IFN and ribavirin, three became sustained viral responders. Two patients treated with pegylated IFN and ribavirin became sustained viral responders. In our region, genotype 5 patients seem to have been contaminated within a relatively short time period. Treatment with IFN or pegylated IFN and ribavirin gave a high rate (83%) of sustained viral responses. [less ▲] Detailed reference viewed: 38 (8 ULg) Tuareg ethnodiagnostic skill of camel diseases in Agadez area (Niger)Antoine-Moussiaux, Nicolas ; ; in Journal of Camel Practice and Research (2005), 12(2), 85-93 For generations, nomad herders have been learning to manage herd health, particularly in dromedary because of its high value. They have thus acquired a very comprehensive knowledge of camel's illness ... [more ▼] For generations, nomad herders have been learning to manage herd health, particularly in dromedary because of its high value. They have thus acquired a very comprehensive knowledge of camel's illness signs and have developed their own nomenclature. The present study aims at the description, scientific identification and recognition of this ethnoveterinary knowledge by means of an investigation carried out in Tuareg populations living in the neighbourhoods of Agadez (Niger). The dominant pathologies cited by herders for being the most alarming are gastro-intestinal helminthiasis (izni), camel calf diarrhoea (efay), tick infestations of camel calves (igardan), camel pox (erk eshik), sarcoptic mange (ajud) and bronchopneumonia (toza). Poorly identified nosologic entities are also reported. [less ▲] Detailed reference viewed: 68 (4 ULg) La langue française face aux langues de l’immigration – Etat des lieux en Communauté française de BelgiqueMartiniello, Marco ; Scientific conference (2005, November 30) Detailed reference viewed: 7 (0 ULg) Cocaine-conditioned activity persists for a longer time than cocaine-sensitized activity in mice: Implications for the theories using Pavlovian excitatory conditioning to explain the context-specificity of sensitizationTirelli, Ezio ; Michel, Alexa ; Brabant, Christian ![]() in Behavioural Brain Research (2005), 165(1), 18-25 The present study was aimed at testing the prediction of the Pavlovian excitatory conditioning explanation of context-specific sensitization that the sensitized effect (SE) should persist as long as the ... [more ▼] The present study was aimed at testing the prediction of the Pavlovian excitatory conditioning explanation of context-specific sensitization that the sensitized effect (SE) should persist as long as the post-sensitization conditioned activity (CR). C57BL/6J mice were tested for the expression of cocaine-induced conditioned and sensitized locomotion on several intervals after the establishment of a sensitization in an unchanging context. A group of mice received 10 once-daily injections of 10 mg/kg cocaine (s.c.) in a short time prior to being tested in activity-meters for 60 min sessions (cocaine-pretreated group), mice from a control group receiving saline in the same manner (saline-pretreated group). On the test sessions, taking place 1, 8 and 28 days after cocaine pretreatment, half of the animals of each pretreatment group (n=8) received a challenge test with saline and the other half with 10 mg/kg cocaine in the pretreatment context room (for CR and SE tests, respectively). The CR was significantly expressed on the three successive saline-challenge tests, albeit the activity levels were markedly decreased on the 28-day retention test. In contrast, the SE was significantly expressed only during the first half of the 1-day test session and the first 10 min of the 8-day test session, no SE effect being expressed on the 28-day retention test. The results, suggesting a functional uncoupling of the CR from the SE, disprove the theories of context-specificity of sensitization based completely or partially on Pavlovian excitatory conditioning mechanisms. [less ▲] Detailed reference viewed: 24 (1 ULg) Impact of acid containing montmorillonite on the properties of Nafion® membranesThomassin, Jean-Michel ; ; Caldarella, Giuseppe et alin Polymer (2005), 46(25), 11389-11395 The counter-ions of montmorillonite have been exchanged for ammonium cations containing either a sulfonic acid or a carboxylic acid in order to improve the performances of sulfonated membranes in direct ... [more ▼] The counter-ions of montmorillonite have been exchanged for ammonium cations containing either a sulfonic acid or a carboxylic acid in order to improve the performances of sulfonated membranes in direct methanol fuel cell. These layered silicates have been dispersed within Nafion® by solution mixing. Comparison with conventional organo-modified montmorillonite (Cloisite 30B) shows that the incorporation of carboxylic acid in the clay galleries improves the filler dispersion and, consequently, the methanol barrier properties. Moreover, the negative impact of Cloisite 30B on the ionic conductivity is restricted. [less ▲] Detailed reference viewed: 18 (3 ULg) Le traitement clinique du chômageOrianne, Jean-François ![]() Doctoral thesis (2005) Cette thèse prend pour objet une politique publique : la politique du Parcours d’insertion. Menée dans les différents Etats membres de l’Union depuis le milieu des années 1990, au nom d’une meilleure ... [more ▼] Cette thèse prend pour objet une politique publique : la politique du Parcours d’insertion. Menée dans les différents Etats membres de l’Union depuis le milieu des années 1990, au nom d’une meilleure intégration et coordination des multiples actions destinées aux personnes en recherche d’emploi, cette politique « active » d’emploi vise le développement de l’employabilité des chômeurs, entendons par là leur capacité d’insertion socioprofessionnelle, leurs « chances » d’accéder à un emploi durable et de qualité. Nous procédons à l’analyse de cette politique publique sous l’angle, bien particulier, du travail quotidien de trois groupes d’intermédiaires publics du marché du travail chargés de mettre en œuvre cette politique en Région wallonne (Belgique), d’en traduire les énoncés en action sur autrui : les conseillers en accompagnement professionnel du FOREM, les conseillers en formation de Carrefour Formation, les travailleurs sociaux d’Entreprises de Formation par le Travail. L’analyse tend à montrer que l’action de ces intermédiaires oriente le traitement du chômage dans une voie clinique : l’action des intermédiaires publics du marché du travail, qui vise principalement à mettre le chômeur au travail sur lui-même, repose sur la construction professionnelle de « troubles » de l’employabilité. [less ▲] Detailed reference viewed: 189 (16 ULg) Subacute effects of sertraline on attentional and executive functions in depression; Adam, Stéphane ; et alConference (2005, November 26) Detailed reference viewed: 4 (0 ULg) |
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