References of "2005"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailControl of puberty by excitatory amino acid neurotransmitters and its clinical implications
Parent, Anne-Simone ULg; Matagne, V.; Bourguignon, Jean-Pierre ULg

in Endocrine (2005), 28(3), 281-285

Excitatory amino acids, glutamate in particular, have a marked stimulatory effect on the reproductive axis, particulary at puberty. Glutamate, N-methyl-D-aspartate (NMDA), and kainate stimulate ... [more ▼]

Excitatory amino acids, glutamate in particular, have a marked stimulatory effect on the reproductive axis, particulary at puberty. Glutamate, N-methyl-D-aspartate (NMDA), and kainate stimulate gonadotropin-releasing hormone (GnRH) secretion in immature mammals and NMDA receptor stimulation results in precocious puberty in rats and monkeys. Puberty is characterized by an increased sensitivity of GnRH to glutamate as well as an increase in glutaminase activity in the hypothalamus. Glutamatergic and GABAergic regulation of GnRH secretion seem strongly interdependent around puberty. in addition to the transsynaptic glutamatergic regulation of GnRH secretion, a coordinated activity of glutamatergic neurons and astroglial cells has been shown to play an active role in puberty. The participation of kainate receptors in the estradiol-induced advancement of puberty suggest that these receptors may be involved in the estradiol-mediated activation of GnRH secretion at puberty. A case of precocious puberty associated with hyperglycinemia illustrates the NMDA involvement in puberty in humans. in this patient, the occurrence of precocious puberty was thought to result from excessive stimulation by glycine of the NMDA receptors linked to the GnRH neurons. Glutamate plays several roles in the hypothalamic mechanism of puberty as it has been shown in animal models, but there are still few clinical data supporting the role of glutamate in human puberty. [less ▲]

Detailed reference viewed: 25 (2 ULg)
Full Text
Peer Reviewed
See detailOverhead power lines real time monitoring : a future trend ?
Lilien, Jean-Louis ULg; Destiné, Jacques ULg

in Revue d'Electricité et d'Electronique Industrielle (2005), 4

Overview of the needs which exist to monitor overhead lines in real time. Application to ampacity is detailed to determine the load available on a given line at a given time. After an overview of the ... [more ▼]

Overview of the needs which exist to monitor overhead lines in real time. Application to ampacity is detailed to determine the load available on a given line at a given time. After an overview of the existing sensors, a new device is proposed (Ampacimon) and first results are detailed on a 70 kV line. [less ▲]

Detailed reference viewed: 106 (9 ULg)
Full Text
Peer Reviewed
See detailIdentification of a pharmacophore of SKCa channel blockers
Dilly, Sébastien ULg; Graulich, Amaury ULg; Farce, Amaury et al

in Journal of Enzyme Inhibition and Medicinal Chemistry (2005), 20(6), 517-523

Small conductance calcium-activated potassium channels ( SK) are widely expressed throughout the central nervous system ( CNS) and the periphery. Three subtypes of SK channels have so far been identified ... [more ▼]

Small conductance calcium-activated potassium channels ( SK) are widely expressed throughout the central nervous system ( CNS) and the periphery. Three subtypes of SK channels have so far been identified in different parts of the brain. Activation of the SK channels by a rise in intracellular calcium leads to the hyperpolarisation of the membrane, reducing cell excitability. Blocking the SK channels might be beneficial in the treatment of depression, Parkinson's disease and cognitive disorders. However, few blockers of SK channels have been characterized. In this study, a pharmacophoric model of SK channels blockers is presented. It is based on a series of nonpeptidic compounds and apamin, a peptidic blocker. To create the pharmacophore model, the conformational space of nonpeptidic blockers was investigated to generate a series of distance constraints applied to a simulated annealing study of apamin. The resulting conformation was superimposed with the nonpeptidic blockers to give a pharmacophore. [less ▲]

Detailed reference viewed: 33 (5 ULg)
Full Text
Peer Reviewed
See detailModelling the climate effect on Black Grouse Population Dynamic in Rhön Biopshere Reserve
Loneux, Michèle ULg; Kolb, Karl-Heinz; Lindsey, James ULg

in Plummer, Ron (Ed.) Black Grouse Endangered Species (2005, December)

Detailed reference viewed: 13 (0 ULg)
Full Text
Peer Reviewed
See detailModelling the Influence of Climate on Black Grouse Population Dynamics in Lüneburger Heide (North Germany)
Loneux, Michèle ULg; Lütkepohl, Manfred; Wübbenhorst, Jann et al

in PLUMMER, Ron (Ed.) European Conference Black Grouse Endangered species (2005, December)

Detailed reference viewed: 13 (0 ULg)
Full Text
Peer Reviewed
See detailSystem Analysis of a Programmed Cell Death Model
Bullinger, Eric ULg

in IEEE Conference on Decision and Control (2005, December)

Apoptosis is a programmed cell death by which the organism removes unwanted cells. Its core reactions can be described by a system of differential equations exhibiting multiple steady-states. In this ... [more ▼]

Apoptosis is a programmed cell death by which the organism removes unwanted cells. Its core reactions can be described by a system of differential equations exhibiting multiple steady-states. In this paper we analyse how this model can include both very slow dynamics for the lag phase before apoptosis (in theory up to several days) while the apoptosis itself is more switch-like with changes occurring within minutes. We both describe how the trajectories evolve during the lag phase and show which of the states have the most impact on the slow dynamics. [less ▲]

Detailed reference viewed: 8 (1 ULg)
Full Text
Peer Reviewed
See detailFactors affecting black grouse numbers : an overview of the part of predators. European conference, black grouse endangered species,
Loneux, Michèle ULg; Kolb, Karl-Heinz; Ruwet, Jean-Claude et al

in PLUMMER, Ron (Ed.) European Conference 'Cynhadledd Ceiliog Y Rhos' Black Grouse Endangered Species (2005, December)

Detailed reference viewed: 23 (2 ULg)
Full Text
Peer Reviewed
See detailTriggering mechanisms of limit cycle oscillations due to aeroelastic instability
Lee, Y. S.; Vakakis, Alexander F.; Bergman, Lawrence A. et al

in Journal of Fluids & Structures (2005), 21

We show that a cascade of resonance captures constitutes the triggering mechanism of limit cycle oscillations (LCOs) due to aeroelastic instability of rigid wings in flow. We consider a two-degree-of ... [more ▼]

We show that a cascade of resonance captures constitutes the triggering mechanism of limit cycle oscillations (LCOs) due to aeroelastic instability of rigid wings in flow. We consider a two-degree-of-freedom (2-dof) wing model in subsonic flow with cubic nonlinear stiffnesses at the support. Under the assumption of quasi-steady aerodynamics, we apply a complexification/averaging technique to express the dynamics of fluid-structure interactions in terms of three fast-frequency components; these are the two linear natural frequencies corresponding to heave and pitch, and a superharmonic at three times the pitch frequency. Bifurcation analysis of the resulting set of modulation equations governing the slow dynamics is carried out via the method of numerical continuation, and reveals the different types of steady state motions realized as parameters vary. It turns out that the LCO triggering mechanism consists of a combination of different dynamic phenomena, taking place at three main stages or regimes: attraction to transient resonance captures (TRCs), escapes from these captures and, finally, entrapments into permanent resonance captures (PRCs). We examine numerically and analytically the dynamics at each of these stages by means of wavelet transform analysis, study of the evolution of appropriately defined phase variables in projections of the phase space of the dynamics, and analysis of instantaneous energy exchanges between the various nonlinear modes involved. The general conclusion is that an initial excitation of the heave mode by the flow acts as the triggering mechanism for the excitation of the pitch mode through nonlinear interactions resulting from the resonance captures and escapes. The eventual excitation of the pitch mode signifies the appearance of an LCO of the in-flow wing. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 48 (2 ULg)
Full Text
Peer Reviewed
See detailThree year joint space narrowing predicts long term incidence of knee surgery in patients with osteoarthritis: an eight year prospective follow up study
Bruyère, Olivier ULg; Richy, F.; Reginster, Jean-Yves ULg

in Annals of the Rheumatic Diseases (2005), 64(12), 1727-1730

OBJECTIVE: To assess the clinical relevance of mean and minimum femorotibial joint space narrowing (JSN) for predicting future osteoarthritis related surgery in patients with knee osteoarthritis. METHODS ... [more ▼]

OBJECTIVE: To assess the clinical relevance of mean and minimum femorotibial joint space narrowing (JSN) for predicting future osteoarthritis related surgery in patients with knee osteoarthritis. METHODS: 126 subjects with primary knee osteoarthritis were followed prospectively for a mean eight years. Minimum and mean joint space width (JSW) were assessed from standard x rays at baseline and after a follow up of three years. The rate of knee osteoarthritis related surgery was recorded for the following five years. RESULTS: After a mean follow up of eight years, 16 patients (12.7%) had received osteoarthritis related joint surgery. The areas under the curves (AUC) resulting from the receiver operating characteristic curve analyses for predicting osteoarthritis surgery were 0.73 (p=0.006) for minimum JSN and 0.55 (p=0.54) for mean JSN. The cut off for minimum JSN maximising sensitivity and specificity for predicting future surgery was a change of 0.7 mm or more in minimum joint space width over a period of three years. However, no meaningful differences were observed for cut off values between 0.5 and 0.8 mm The relative risk (adjusted for age, body mass index, baseline symptoms, and baseline JSW) of experiencing osteoarthritis related surgery during the eight year of follow up was 5.15 (95% confidence interval, 1.70 to 15.60) (p=0.004) in patients with a minimum joint space narrowing of 0.7 mm or more during the first three years of the study. CONCLUSIONS: A cut off of 0.5 to 0.8 mm in minimum JSN, measured on standard x rays, reflects a clinically relevant progression in patients with knee osteoarthritis. [less ▲]

Detailed reference viewed: 40 (9 ULg)
Full Text
Peer Reviewed
See detailQuantifying consciousness
Laureys, Steven ULg; Piret, Sonia ULg; Ledoux, Didier ULg

in Lancet Neurology (2005), 4(12), 789-790

Detailed reference viewed: 47 (2 ULg)
Full Text
Peer Reviewed
See detailDépression et maladies coronariennes: quand les émotions nous brisent le coeur...
Massart, Nicolas ULg; Triffaux, Jean-Marc ULg

in Revue Médicale de Liège (2005), 60(12), 931-8

Depression and cardiovascular diseases represent a major public health problem worldwide. Recent studies have shown that depression is a risk factor for the development of coronary artery disease (CAD) in ... [more ▼]

Depression and cardiovascular diseases represent a major public health problem worldwide. Recent studies have shown that depression is a risk factor for the development of coronary artery disease (CAD) in healthy people and also increases morbidity and mortality in depressed patients with CAD. Others studies have shown that selective serotonin inhibitors (SSRIs) constitute a safe and effective treatment for depressed patients with heart disease. There are also data suggesting that treating depression with SSRIs has a protective role in myocardial infarction and may improve outcomes, including mortality. [less ▲]

Detailed reference viewed: 161 (2 ULg)
Full Text
Peer Reviewed
See detailResidual cognitive function in comatose, vegetative and minimally conscious states
Laureys, Steven ULg; Perrin, F.; Schnakers, Caroline ULg et al

in Current Opinion In Neurology (2005), 18(6), 726-733

Purpose of review The clinical evaluation of cognition in non-communicative severely brain-damaged patients is inherently difficult. In addition to novel behavioural 'consciousness-scales', the role of ... [more ▼]

Purpose of review The clinical evaluation of cognition in non-communicative severely brain-damaged patients is inherently difficult. In addition to novel behavioural 'consciousness-scales', the role of para-clinical markers of consciousness, such as event related potentials and functional neuroimaging is reviewed. Recent findings New behavioural scales for vegetative and minimally conscious patients have been shown to reduce diagnostic error but regrettably remain underused in clinical routine. Electrophysiological studies have confirmed their role in estimating outcome and possibly cognition. Several recent functional neuroimaging studies have shown residual cortical function in undeniably vegetative patients. This cortical activation, however, seems limited to primary 'low-level' areas and does not imply 'higher-order' integration, considered necessary for conscious perception. Minimally conscious patients show large-scale high-order cerebral activation, apparently dependent upon the emotional relevance of the stimulation. Summary Careful clinical assessment of putative 'conscious behaviour' in vegetative and minimally conscious patients is the first requirement for their proper diagnosis and management. Complementary functional neuroimaging and electrophysiological studies will have a major impact on future clinical decision making and may guide selective therapeutic options. At present, more experimental evidence and the elucidation of methodological and ethical controversies are awaited prior to their routine clinical use. [less ▲]

Detailed reference viewed: 23 (5 ULg)
Full Text
See detailMise en place d’une stratégie de communication et de contrôle de la qualité écologique et sociale fondée sur l’étiquetage, les indications de qualité et la force de marque pour les vêtements, les articles de sport et les voitures
Fraselle, Nadine; Van Caillie, Didier ULg

Report (2005)

This report describes which are the practices implemented by firms in the furnishment industry, in the auto industry and in the sport industry to signal and to control the external Ecological and Societal ... [more ▼]

This report describes which are the practices implemented by firms in the furnishment industry, in the auto industry and in the sport industry to signal and to control the external Ecological and Societal Quality of their products. [less ▲]

Detailed reference viewed: 68 (2 ULg)
Full Text
Peer Reviewed
See detailIntegration de la pharmacogenetique dans la pratique medicale
Dideberg, Vinciane ULg; Bours, Vincent ULg

in Revue Médicale de Liège (2005), 60(12), 918-22

Today, the initiation of any medical treatment still raises questions about its efficacy and safety. Indeed, therapeutic responses vary over time and between individuals and are influenced by age, sex ... [more ▼]

Today, the initiation of any medical treatment still raises questions about its efficacy and safety. Indeed, therapeutic responses vary over time and between individuals and are influenced by age, sex, other treatments and the pathology itself. Genetic factors are thought to be responsible for 20 to 95% of these individual variations. Recent advances in biotechnology, molecular genetics and genomics allow a better understanding of drug metabolism and action. Pharmacogenetics, compiling phenotypic and genotypic data, may lead to a more personalized treatment. To allow a better approach of pharmacogenetics and pharmacogenomics, we will define these two terms and describe their actual and future clinical application. [less ▲]

Detailed reference viewed: 71 (0 ULg)
Full Text
Peer Reviewed
See detailFeeding ecology of five commercial shark species of the Celtic Sea through stable isotope and trace metal analysis
Domi, Nadège; Bouquegneau, Jean-Marie ULg; Das, Krishna ULg

in Marine Environmental Research (2005), 60(5),

In order to trace their feeding habits, stable carbon and nitrogen isotope ratios (delta(15)N and delta(13)C), as well as trace metal concentrations (Zn, Cd, Fe, Cu, Se and Hg) were analysed in the ... [more ▼]

In order to trace their feeding habits, stable carbon and nitrogen isotope ratios (delta(15)N and delta(13)C), as well as trace metal concentrations (Zn, Cd, Fe, Cu, Se and Hg) were analysed in the tissues of five commercial shark species from the Celtic Sea: the tope shark Galeorhinus galeus, the black-mouthed catshark Galeus melastomus, the starry smooth hound Mustelus asterias, the spiny dogfish Squalus acanthias and the lesser-spotted dogfish Scyliorhinus canicula. Our results were compared to previously described stomach contents and isotopic composition of potential preys. Isotopic ratio delta(15)N suggested that tope sharks fed at a higher trophic level (16.7 parts per thousand in the muscle) than the other species, reflecting its piscivorous diet. The lower values of spiny dogfish (11.6 parts per thousand in the muscle) might be explained, amongst other things, by either its migratory behaviour or its preference for preys from lower trophic levels. Cd and Hg were correlated with isotopic ratios delta(13)C and delta(15)N, and were shown to be diet-related whereas Zn, Fe and Cu seemed much more linked to species-specific metabolism. Although this multidisciplinary approach is revealed as a useful tool for the study of shark ecology, the lack of known trophic fractionation suggests that isotopic data be compared to traditional diet analyses. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 107 (23 ULg)
Full Text
Peer Reviewed
See detailInfluence of emotion on memory for temporal information
D'Argembeau, Arnaud ULg; Van der Linden, Martial ULg

in Emotion (Washington, D.C.) (2005), 5(4), 503-507

Contextual information. such as color and spatial location, has been found to be better remembered for emotional than for neutral items. The current study examined whether the influence of emotion extends ... [more ▼]

Contextual information. such as color and spatial location, has been found to be better remembered for emotional than for neutral items. The current study examined whether the influence of emotion extends to memory for another fundamental feature of episodic memory: temporal information. Results from a list-discrimination paradigm showed that (a) item memory was enhanced for both negative and positive pictures compared with neutral ones and was better for negative than for positive pictures and (b) temporal information was better remembered for negative than for positive and neutral pictures, whereas positive and neutral pictures did not differ from each other. These findings are discussed in relation to the processes involved in memory for temporal information. [less ▲]

Detailed reference viewed: 125 (6 ULg)
See detailConséquences de la chirurgie de transposition du muscle grand dorsal
Forthomme, Bénédicte ULg; Heymans, Olivier; Grandjean, François-Xavier ULg et al

in Abstract book de la 5ème Journée Belge d’Isocinétisme du GIBL (2005, December)

Detailed reference viewed: 60 (1 ULg)