References of "2005"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailIdentification of a pharmacophore of SKCa channel blockers
Dilly, Sébastien ULiege; Graulich, Amaury ULiege; Farce, Amaury et al

in Journal of Enzyme Inhibition and Medicinal Chemistry (2005), 20(6), 517-523

Small conductance calcium-activated potassium channels ( SK) are widely expressed throughout the central nervous system ( CNS) and the periphery. Three subtypes of SK channels have so far been identified ... [more ▼]

Small conductance calcium-activated potassium channels ( SK) are widely expressed throughout the central nervous system ( CNS) and the periphery. Three subtypes of SK channels have so far been identified in different parts of the brain. Activation of the SK channels by a rise in intracellular calcium leads to the hyperpolarisation of the membrane, reducing cell excitability. Blocking the SK channels might be beneficial in the treatment of depression, Parkinson's disease and cognitive disorders. However, few blockers of SK channels have been characterized. In this study, a pharmacophoric model of SK channels blockers is presented. It is based on a series of nonpeptidic compounds and apamin, a peptidic blocker. To create the pharmacophore model, the conformational space of nonpeptidic blockers was investigated to generate a series of distance constraints applied to a simulated annealing study of apamin. The resulting conformation was superimposed with the nonpeptidic blockers to give a pharmacophore. [less ▲]

Detailed reference viewed: 39 (5 ULiège)
Full Text
Peer Reviewed
See detailModelling the climate effect on Black Grouse Population Dynamic in Rhön Biopshere Reserve
Loneux, Michèle ULiege; Kolb, Karl-Heinz; Lindsey, James ULiege

in Plummer, Ron (Ed.) Black Grouse Endangered Species (2005, December)

Detailed reference viewed: 16 (0 ULiège)
Full Text
Peer Reviewed
See detailModelling the Influence of Climate on Black Grouse Population Dynamics in Lüneburger Heide (North Germany)
Loneux, Michèle ULiege; Lütkepohl, Manfred; Wübbenhorst, Jann et al

in PLUMMER, Ron (Ed.) European Conference Black Grouse Endangered species (2005, December)

Detailed reference viewed: 14 (0 ULiège)
Full Text
Peer Reviewed
See detailFactors affecting black grouse numbers : an overview of the part of predators. European conference, black grouse endangered species,
Loneux, Michèle ULiege; Kolb, Karl-Heinz; Ruwet, Jean-Claude et al

in PLUMMER, Ron (Ed.) European Conference 'Cynhadledd Ceiliog Y Rhos' Black Grouse Endangered Species (2005, December)

Detailed reference viewed: 26 (2 ULiège)
Full Text
Peer Reviewed
See detailTriggering mechanisms of limit cycle oscillations due to aeroelastic instability
Lee, Y. S.; Vakakis, Alexander F.; Bergman, Lawrence A. et al

in Journal of Fluids & Structures (2005), 21

We show that a cascade of resonance captures constitutes the triggering mechanism of limit cycle oscillations (LCOs) due to aeroelastic instability of rigid wings in flow. We consider a two-degree-of ... [more ▼]

We show that a cascade of resonance captures constitutes the triggering mechanism of limit cycle oscillations (LCOs) due to aeroelastic instability of rigid wings in flow. We consider a two-degree-of-freedom (2-dof) wing model in subsonic flow with cubic nonlinear stiffnesses at the support. Under the assumption of quasi-steady aerodynamics, we apply a complexification/averaging technique to express the dynamics of fluid-structure interactions in terms of three fast-frequency components; these are the two linear natural frequencies corresponding to heave and pitch, and a superharmonic at three times the pitch frequency. Bifurcation analysis of the resulting set of modulation equations governing the slow dynamics is carried out via the method of numerical continuation, and reveals the different types of steady state motions realized as parameters vary. It turns out that the LCO triggering mechanism consists of a combination of different dynamic phenomena, taking place at three main stages or regimes: attraction to transient resonance captures (TRCs), escapes from these captures and, finally, entrapments into permanent resonance captures (PRCs). We examine numerically and analytically the dynamics at each of these stages by means of wavelet transform analysis, study of the evolution of appropriately defined phase variables in projections of the phase space of the dynamics, and analysis of instantaneous energy exchanges between the various nonlinear modes involved. The general conclusion is that an initial excitation of the heave mode by the flow acts as the triggering mechanism for the excitation of the pitch mode through nonlinear interactions resulting from the resonance captures and escapes. The eventual excitation of the pitch mode signifies the appearance of an LCO of the in-flow wing. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 53 (4 ULiège)
Full Text
Peer Reviewed
See detailThree year joint space narrowing predicts long term incidence of knee surgery in patients with osteoarthritis: an eight year prospective follow up study
Bruyère, Olivier ULiege; Richy, F.; Reginster, Jean-Yves ULiege

in Annals of the Rheumatic Diseases (2005), 64(12), 1727-1730

OBJECTIVE: To assess the clinical relevance of mean and minimum femorotibial joint space narrowing (JSN) for predicting future osteoarthritis related surgery in patients with knee osteoarthritis. METHODS ... [more ▼]

OBJECTIVE: To assess the clinical relevance of mean and minimum femorotibial joint space narrowing (JSN) for predicting future osteoarthritis related surgery in patients with knee osteoarthritis. METHODS: 126 subjects with primary knee osteoarthritis were followed prospectively for a mean eight years. Minimum and mean joint space width (JSW) were assessed from standard x rays at baseline and after a follow up of three years. The rate of knee osteoarthritis related surgery was recorded for the following five years. RESULTS: After a mean follow up of eight years, 16 patients (12.7%) had received osteoarthritis related joint surgery. The areas under the curves (AUC) resulting from the receiver operating characteristic curve analyses for predicting osteoarthritis surgery were 0.73 (p=0.006) for minimum JSN and 0.55 (p=0.54) for mean JSN. The cut off for minimum JSN maximising sensitivity and specificity for predicting future surgery was a change of 0.7 mm or more in minimum joint space width over a period of three years. However, no meaningful differences were observed for cut off values between 0.5 and 0.8 mm The relative risk (adjusted for age, body mass index, baseline symptoms, and baseline JSW) of experiencing osteoarthritis related surgery during the eight year of follow up was 5.15 (95% confidence interval, 1.70 to 15.60) (p=0.004) in patients with a minimum joint space narrowing of 0.7 mm or more during the first three years of the study. CONCLUSIONS: A cut off of 0.5 to 0.8 mm in minimum JSN, measured on standard x rays, reflects a clinically relevant progression in patients with knee osteoarthritis. [less ▲]

Detailed reference viewed: 43 (9 ULiège)
Full Text
Peer Reviewed
See detailDépression et maladies coronariennes: quand les émotions nous brisent le coeur...
Massart, Nicolas ULiege; Triffaux, Jean-Marc ULiege

in Revue Médicale de Liège (2005), 60(12), 931-8

Depression and cardiovascular diseases represent a major public health problem worldwide. Recent studies have shown that depression is a risk factor for the development of coronary artery disease (CAD) in ... [more ▼]

Depression and cardiovascular diseases represent a major public health problem worldwide. Recent studies have shown that depression is a risk factor for the development of coronary artery disease (CAD) in healthy people and also increases morbidity and mortality in depressed patients with CAD. Others studies have shown that selective serotonin inhibitors (SSRIs) constitute a safe and effective treatment for depressed patients with heart disease. There are also data suggesting that treating depression with SSRIs has a protective role in myocardial infarction and may improve outcomes, including mortality. [less ▲]

Detailed reference viewed: 220 (2 ULiège)
Full Text
Peer Reviewed
See detailIntegration de la pharmacogenetique dans la pratique medicale
Dideberg, Vinciane ULiege; Bours, Vincent ULiege

in Revue Médicale de Liège (2005), 60(12), 918-22

Today, the initiation of any medical treatment still raises questions about its efficacy and safety. Indeed, therapeutic responses vary over time and between individuals and are influenced by age, sex ... [more ▼]

Today, the initiation of any medical treatment still raises questions about its efficacy and safety. Indeed, therapeutic responses vary over time and between individuals and are influenced by age, sex, other treatments and the pathology itself. Genetic factors are thought to be responsible for 20 to 95% of these individual variations. Recent advances in biotechnology, molecular genetics and genomics allow a better understanding of drug metabolism and action. Pharmacogenetics, compiling phenotypic and genotypic data, may lead to a more personalized treatment. To allow a better approach of pharmacogenetics and pharmacogenomics, we will define these two terms and describe their actual and future clinical application. [less ▲]

Detailed reference viewed: 86 (0 ULiège)
Full Text
Peer Reviewed
See detailFeeding ecology of five commercial shark species of the Celtic Sea through stable isotope and trace metal analysis
Domi, Nadège; Bouquegneau, Jean-Marie ULiege; Das, Krishna ULiege

in Marine Environmental Research (2005), 60(5),

In order to trace their feeding habits, stable carbon and nitrogen isotope ratios (delta(15)N and delta(13)C), as well as trace metal concentrations (Zn, Cd, Fe, Cu, Se and Hg) were analysed in the ... [more ▼]

In order to trace their feeding habits, stable carbon and nitrogen isotope ratios (delta(15)N and delta(13)C), as well as trace metal concentrations (Zn, Cd, Fe, Cu, Se and Hg) were analysed in the tissues of five commercial shark species from the Celtic Sea: the tope shark Galeorhinus galeus, the black-mouthed catshark Galeus melastomus, the starry smooth hound Mustelus asterias, the spiny dogfish Squalus acanthias and the lesser-spotted dogfish Scyliorhinus canicula. Our results were compared to previously described stomach contents and isotopic composition of potential preys. Isotopic ratio delta(15)N suggested that tope sharks fed at a higher trophic level (16.7 parts per thousand in the muscle) than the other species, reflecting its piscivorous diet. The lower values of spiny dogfish (11.6 parts per thousand in the muscle) might be explained, amongst other things, by either its migratory behaviour or its preference for preys from lower trophic levels. Cd and Hg were correlated with isotopic ratios delta(13)C and delta(15)N, and were shown to be diet-related whereas Zn, Fe and Cu seemed much more linked to species-specific metabolism. Although this multidisciplinary approach is revealed as a useful tool for the study of shark ecology, the lack of known trophic fractionation suggests that isotopic data be compared to traditional diet analyses. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 113 (23 ULiège)
See detail“Écrire pour son époque”. Sartre, de l’entre-deux-guerres à la Guerre froide
Denis, Benoît ULiege

Conference (2005, December)

Detailed reference viewed: 160 (0 ULiège)
Full Text
See detailDétermination des zones de prévention du site de captage d'Onoz
Henrion, Vincent; Dassargues, Alain ULiege

Report (2005)

Detailed reference viewed: 16 (0 ULiège)
Full Text
Peer Reviewed
See detailRessources humaines et marketing: un mariage stratégique
Robert, Jocelyne ULiege

Article for general public (2005)

Detailed reference viewed: 143 (11 ULiège)
Full Text
See detailNovel diagnostic approach to carpal tunnel syndrome
WANG, François-Charles ULiege; GERARD, Pascale ULiege; ISERENTANT, Cynthia ULiege

Scientific conference (2005, December)

Detailed reference viewed: 14 (4 ULiège)
Full Text
Peer Reviewed
See detailOptimization of poly(2-(dimethylamino)ethyl methacrylate)-co-poly(ethyleneglycol)/DNA complexes designed for cell transfection
Grandfils, Christian ULiege; Emonds-Alt, J.

in Minerva Biotecnologica (2005), 17(4), 237-243

Cell transfection relies upon the delivery of genomic material within cells in order to express selected DNA sequences. Non-viral gene delivery systems are preferable over viral vectors for several ... [more ▼]

Cell transfection relies upon the delivery of genomic material within cells in order to express selected DNA sequences. Non-viral gene delivery systems are preferable over viral vectors for several reasons: biosafety, low immunogenicity, higher loading capacity, and easiness of production. Their major drawbacks actually are their limited efficiency in vivo compared to viruses, their cytotoxicity and the fact that they are rapidly cleared up from the bloodstream. The aim of our study was to better characterize the physico-chemical behavior of the polycations based on poly(2-(dimethylamino)ethyl methacrylate)-co-poly(ethyleneglycol) and to control the formulation step to produce the polyelectrolyte complexes. [less ▲]

Detailed reference viewed: 40 (3 ULiège)
Full Text
Peer Reviewed
See detailPotential benefits of laparoscopic aorto-bifemoral bypass surgery
Rouers, Anthony; MEURISSE, Nicolas; LAVIGNE, Jean-Paul ULiege et al

in Acta Chirurgica Belgica (2005), 105(6), 610-615

Background: This series aims to prove the positive impact of laparoscopic approach in aortofemoral bypass grafting. Methods : It concerns a retrospective non randomized study comparing 58 consecutive ... [more ▼]

Background: This series aims to prove the positive impact of laparoscopic approach in aortofemoral bypass grafting. Methods : It concerns a retrospective non randomized study comparing 58 consecutive patients treated with laparoscopic procedure (n = 30) and with a standard open procedure (n = 28) in a single center. The different operating times, the complications and the follow-up of these two groups are compared Results : The demographics and angiographic data of the two groups were comparable. Operating time was longer in the laparoscopic group. However, we noticed a significant shorter hospitalisation stay (p < 0.0001) after the laparoscopic procedure with a mean 5.1 days. There was no significant difference of morbidity. Conclusion : We suggest that the trans-peritoneal approach is the best way in laparoscopic procedure in term of exposure and ergonomics. Laparoscopic aortofemoral bypass grafting is feasible, safe and effective. Shortening of operating time is observed as surgeon's experience grows. [less ▲]

Detailed reference viewed: 82 (1 ULiège)
Full Text
Peer Reviewed
See detailSimulation of complex impact problems with implicit time algorithms: Application to a turbo-engine blade loss problem
Noels, Ludovic ULiege; Stainier, Laurent ULiege; Ponthot, Jean-Philippe ULiege

in International Journal of Impact Engineering (2005), 32(1-4), 358386

Recent developments, in non-linear structural dynamics, have led to a new kind of implicit algorithms: the energy-momentum conserving algorithm (EMCA) and the energy-dissipative, momentum-conserving ... [more ▼]

Recent developments, in non-linear structural dynamics, have led to a new kind of implicit algorithms: the energy-momentum conserving algorithm (EMCA) and the energy-dissipative, momentum-conserving algorithm. Contrarily to commonly used algorithms, such as the explicit central difference or the alpha-generalized method, the stability of those algorithms is always ensured in the non-linear range. Thanks to this unconditional stability the only requirement on the time step size is that it must be small enough to capture the physics. This requirement is less restrictive than a conditional stability. In previous works, we have developed a new formulation of the internal forces for a hypoelastic model, that leads to an EMCA. In this paper, we will extend this formulation to an energy-dissipative, momentum-conserving algorithm. We will prove with an academic example, that our algorithm is more accurate than the alpha-generalized method in the non-linear range. Then we will simulate a blade loss problem to demonstrate the efficiency of our developments on complex dynamics simulations. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 63 (3 ULiège)
Full Text
See detailPMTIC - Plan Mobilisateur des Technologies de l'Information et de la Communication
Georges, François ULiege; Van de Poël, Jean-François ULiege; Verpoorten, Ingrid ULiege et al

Report (2005)

Projet de recherche-action visant la formation des demandeurs d'emploi en Région Wallonne.

Detailed reference viewed: 18 (4 ULiège)