References of "2005"
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See detailRespektvolle Würdigung Kurt Sontheimer wirbt für Hannah Arendt
Pontzen, Alexandra ULg

in Literaturkritik.de (2005)

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See detailSK channels control the firing pattern of midbrain dopaminergic neurons in vivo
Waroux, Olivier ULg; Massotte, Laurent ULg; Alleva, Livia ULg et al

in European Journal of Neuroscience (2005), 22(12), 3111-3121

A vast body of experimental in vitro work and modelling studies suggests that the firing pattern and/or rate of a majority of midbrain dopaminergic neurons may be controlled in part by Ca2+-activated K ... [more ▼]

A vast body of experimental in vitro work and modelling studies suggests that the firing pattern and/or rate of a majority of midbrain dopaminergic neurons may be controlled in part by Ca2+-activated K+ channels of the SK type. However, due to the lack of suitable tools, in vivo evidence is lacking. We have taken advantage of the development of the water-soluble, medium potency SK blocker N-methyl-laudanosine (CH3-L) to test this hypothesis in anaesthetized rats. In the lateral ventral tegmental area, CH3-L iontophoresis onto dopaminergic neurons significantly increased the coefficient of variation of their interspike intervals and the percentage of spikes generated in bursts as compared to the control condition. The effect of CH3-L persisted in the presence of a specific GABA(A) antagonist, suggesting a direct effect. It was robust and reversible, and was also observed in the substantia nigra. Control experiments demonstrated that the effect of CH3-L could be entirely ascribed to its blockade of SK channels. On the other hand, the firing pattern of noradrenergic neurons was much less affected by CH3-L. We provide here the first demonstration of a major role of SK channels in the control of the switch between tonic and burst firing of dopaminergic neurons in physiological conditions. This study also suggests a new strategy to develop modulators of the dopaminergic (DA) system, which could be of interest in the treatment of Parkinson's disease, and perhaps other diseases in which DA pathways are dysfunctional. [less ▲]

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See detailAge et perception du stress et des conditions de travail
Peters, Stéphanie ULg

Conference given outside the academic context (2005)

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See detailOccipital nerve stimulation in refractory chronic cluster headache: a pilot study of efficacy and mechanisms in five patients
Magis, Delphine ULg; Allena, M.; Vandenheede, Michel et al

in Cephalalgia : An International Journal of Headache (2005, December), 25(12), 1197

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See detailDiffusion du WOCCQ : le temps de l’évaluation
Peters, Stéphanie ULg; Bracci, Elisa; Hansez, Isabelle ULg

Conference given outside the academic context (2005)

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See detailHealthcare consumption and direct costs of rheumatoid arthritis in Belgium
Westhovens, R.; Boonen, A.; Verbruggen, L. et al

in Clinical Rheumatology (2005), 24(6), 615-619

The aim of this study was to compare the socioeconomic consequences of early and late rheumatoid arthritis in Belgium and to assess the patient out-of-pocket contributions. This multicentre longitudinal ... [more ▼]

The aim of this study was to compare the socioeconomic consequences of early and late rheumatoid arthritis in Belgium and to assess the patient out-of-pocket contributions. This multicentre longitudinal study in Belgium evaluated patients with rheumatoid arthritis. Early disease was defined as diagnosis since less than 1 year. At baseline sociodemographic and disease characteristics were assessed and during the following year patients recorded all healthcare- and non-healthcare-related direct costs and out-of-pocket contributions. The study included 48 patients with early and 85 patients with late rheumatoid arthritis. Mean disease duration was 0.5 vs 12.5 years in patients with early and late rheumatoid arthritis, respectively. The disease activity score (DAS28) was comparable between both groups (4.1 vs 4.5, p=0.14), but physical function (Health Assessment Questionnaire, HAQ) was more impaired in patients with long-standing disease (1.0 vs 1.7, p < 0.001). Work disability had increased from 2% in patients with early to 18% in patients with late disease. The annual societal direct costs per patient were E 3055 (median: E 1518) opposed to E 9946 (median: E 4017) for early and late rheumatoid arthritis, respectively. The higher direct cost for patients with long-standing disease was seen for all categories, but especially for physiotherapy and need for devices and adaptations. Patients with early as well as late disease contribute out of pocket about one-third to the direct healthcare costs. Within each group, HAQ was a strong determinant of costs. In Belgium, patients with long-standing rheumatoid arthritis are nine times more likely to be work disabled than patients with less than 1 year disease duration and have a threefold increase in costs. Differences in healthcare consumption between patients could be mainly explained by differences in physical function (HAQ). [less ▲]

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See detailTour du monde de l'édition belge
Habrand, Tanguy ULg

Article for general public (2005)

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See detailWhat controls pCO2 dynamics in Antarctic sea ice and related air-ice CO2 fluxes?
Delille, Bruno ULg; Schoemann, Véronique; Lancelot, Christiane et al

Poster (2005, December)

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See detailA freehand-sketch environment for architectural design supported by a multi-agent system
Juchmes, Roland ULg; Leclercq, Pierre ULg; Azar, Sleiman

in Computers & Graphics (2005), 29(6),

This paper presents an on-line system for capturing and interpreting architectural sketches. The prototype is based on a multi-agent system, which enables real-time management of recognition scenarios. We ... [more ▼]

This paper presents an on-line system for capturing and interpreting architectural sketches. The prototype is based on a multi-agent system, which enables real-time management of recognition scenarios. We describe the different types of agents, their characteristics, the basic mechanisms involved in interpreting freehand architectural drawings and the collaboration modes between agents. Finally, we illustrate the general operations of the system by a short example. r 2005 Elsevier Ltd. All rights reserved. [less ▲]

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See detailOverhead power lines real time monitoring : a future trend ?
Lilien, Jean-Louis ULg; Destiné, Jacques ULg

in Revue d'Electricité et d'Electronique Industrielle (2005), 4

Overview of the needs which exist to monitor overhead lines in real time. Application to ampacity is detailed to determine the load available on a given line at a given time. After an overview of the ... [more ▼]

Overview of the needs which exist to monitor overhead lines in real time. Application to ampacity is detailed to determine the load available on a given line at a given time. After an overview of the existing sensors, a new device is proposed (Ampacimon) and first results are detailed on a 70 kV line. [less ▲]

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See detailResidual cognitive function in comatose, vegetative and minimally conscious states
Laureys, Steven ULg; Perrin, F.; Schnakers, Caroline ULg et al

in Current Opinion In Neurology (2005), 18(6), 726-733

Purpose of review The clinical evaluation of cognition in non-communicative severely brain-damaged patients is inherently difficult. In addition to novel behavioural 'consciousness-scales', the role of ... [more ▼]

Purpose of review The clinical evaluation of cognition in non-communicative severely brain-damaged patients is inherently difficult. In addition to novel behavioural 'consciousness-scales', the role of para-clinical markers of consciousness, such as event related potentials and functional neuroimaging is reviewed. Recent findings New behavioural scales for vegetative and minimally conscious patients have been shown to reduce diagnostic error but regrettably remain underused in clinical routine. Electrophysiological studies have confirmed their role in estimating outcome and possibly cognition. Several recent functional neuroimaging studies have shown residual cortical function in undeniably vegetative patients. This cortical activation, however, seems limited to primary 'low-level' areas and does not imply 'higher-order' integration, considered necessary for conscious perception. Minimally conscious patients show large-scale high-order cerebral activation, apparently dependent upon the emotional relevance of the stimulation. Summary Careful clinical assessment of putative 'conscious behaviour' in vegetative and minimally conscious patients is the first requirement for their proper diagnosis and management. Complementary functional neuroimaging and electrophysiological studies will have a major impact on future clinical decision making and may guide selective therapeutic options. At present, more experimental evidence and the elucidation of methodological and ethical controversies are awaited prior to their routine clinical use. [less ▲]

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See detailPatterns of physical activity determined by heart rate monitoring among diabetic children
Massin, M. M.; Lebrethon, M. C.; Brumioul, Danielle ULg et al

in Archives of Disease in Childhood (2005), 90(12), 1223-1226

Background: Children with type 1 diabetes should be encouraged to participate in physical activity because exercise can benefit insulin sensitivity and improve known risk factors for atherosclerosis ... [more ▼]

Background: Children with type 1 diabetes should be encouraged to participate in physical activity because exercise can benefit insulin sensitivity and improve known risk factors for atherosclerosis. Methods: Physical activity patterns of 127 children and adolescents with stable type 1 diabetes were investigated by 24 hour continuous heart rate monitoring. The percentage of heart rate reserve was used to measure the amounts of physical activity at different intensities. The results were compared with normative data. Results: Diabetic preschoolchildren accumulated 192.7 (78.1), 39.1 (24.3), and 21.3 (9.4) minutes/day (mean (SD)) of light, moderate, and vigorous physical activity, respectively. At the same activity levels, diabetic schoolchildren accumulated 168.9 (76.7), 37.9 (15.9), and 19.0 (14.8) minutes/day, and diabetic teenagers accumulated 166.3 (67.5), 45.6 (26.9), and 25.2 (15.3) minutes/day. Diabetic schoolchildren were significantly more active than healthy peers when considering moderate activity; diabetic teenagers were significantly more active when considering moderate and vigorous activity. There was a negative correlation between the most recent glycated haemoglobin and the time spent in light activities in schoolchildren, and a negative correlation between mean glycated haemoglobin for one year and time spent in light and moderate activities in schoolchildren. Conclusion: The majority of our diabetic patients meet the classical paediatric guidelines for physical activity and compare favourably with their healthy peers. [less ▲]

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See detailIdentification of a pharmacophore of SKCa channel blockers
Dilly, Sébastien ULg; Graulich, Amaury ULg; Farce, Amaury et al

in Journal of Enzyme Inhibition and Medicinal Chemistry (2005), 20(6), 517-523

Small conductance calcium-activated potassium channels ( SK) are widely expressed throughout the central nervous system ( CNS) and the periphery. Three subtypes of SK channels have so far been identified ... [more ▼]

Small conductance calcium-activated potassium channels ( SK) are widely expressed throughout the central nervous system ( CNS) and the periphery. Three subtypes of SK channels have so far been identified in different parts of the brain. Activation of the SK channels by a rise in intracellular calcium leads to the hyperpolarisation of the membrane, reducing cell excitability. Blocking the SK channels might be beneficial in the treatment of depression, Parkinson's disease and cognitive disorders. However, few blockers of SK channels have been characterized. In this study, a pharmacophoric model of SK channels blockers is presented. It is based on a series of nonpeptidic compounds and apamin, a peptidic blocker. To create the pharmacophore model, the conformational space of nonpeptidic blockers was investigated to generate a series of distance constraints applied to a simulated annealing study of apamin. The resulting conformation was superimposed with the nonpeptidic blockers to give a pharmacophore. [less ▲]

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See detailModelling the climate effect on Black Grouse Population Dynamic in Rhön Biopshere Reserve
Loneux, Michèle ULg; Kolb, Karl-Heinz; Lindsey, James ULg

in Plummer, Ron (Ed.) Black Grouse Endangered Species (2005, December)

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See detailModelling the Influence of Climate on Black Grouse Population Dynamics in Lüneburger Heide (North Germany)
Loneux, Michèle ULg; Lütkepohl, Manfred; Wübbenhorst, Jann et al

in PLUMMER, Ron (Ed.) European Conference Black Grouse Endangered species (2005, December)

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