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See detailLanreotide Autogel for acromegaly: a new addition to the treatment armamentarium.
Ciccarelli, Antonio; Daly, Adrian ULg; Beckers, Albert ULg

in Treatments in Endocrinology (2004), 3(2), 77-81

Since their introduction into clinical practice, somatostatin analogs have been the pharmacological therapy of choice for the treatment of acromegaly. The first preparations of somatostatin analogs ... [more ▼]

Since their introduction into clinical practice, somatostatin analogs have been the pharmacological therapy of choice for the treatment of acromegaly. The first preparations of somatostatin analogs available for clinical use were administered subcutaneously two or three times daily, which was not optimal with respect to patient compliance. The introduction of long-acting formulations of somatostatin analogs has overcome this inconvenience. Lanreotide Autogel, a new viscous, supersaturated, aqueous solution of lanreotide, is available in a prefilled syringe and administered by deep subcutaneous injection every 28 days. Lanreotide Autogel has different pharmacokinetic properties from the earlier lanreotide slow-release (SR) formulation, which may account for its better tolerability. Furthermore, lanreotide Autogel is at least as efficacious as the other somatostatin analogs in lowering growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels in the majority and in restoring safe GH and age-normalized IGF-1 levels in about 50-60% of patients with acromegaly. In conclusion, lanreotide Autogel is a valuable new addition to the acromegaly treatment armamentarium. Patients receiving intramuscular lanreotide SR injections every 7-14 days can be switched to an appropriate dose of deep subcutaneous lanreotide Autogel every 28 days, without any impact on safety or loss of efficacy. [less ▲]

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See detailOmega-regular model checking
Boigelot, Bernard ULg; Legay, A.; Wolper, Pierre ULg

in Lecture Notes in Computer Science (2004), 2988

"Regular model checking" is the name of a family of techniques for analyzing infinite-state systems in which states are represented by words or trees, sets of states by finite automata on these objects ... [more ▼]

"Regular model checking" is the name of a family of techniques for analyzing infinite-state systems in which states are represented by words or trees, sets of states by finite automata on these objects, and transitions by finite automata operating on pairs of state encodings, i.e. finite-state transducers. In this context, the central problem is then to compute the iterative closure of a finite-state transducer. This paper addresses the use of regular model-checking like techniques for systems whose states are represented by infinite (omega) words. Its main motivation is to show the feasibility and usefulness of this approach through a combination of the necessary theoretical developments, implementation, and experimentation. The iteration technique that is used is adapted from recent work of the authors on the iteration of finite-word transducers. It proceeds by comparing successive elements of a sequence of approximations of the iteration, detecting an "increment" that is added to move from one approximation to the next, and extrapolating the sequence by allowing arbitrary repetitions of this increment. By restricting oneself to weak deterministic Buchi automata, and using a number of implementation optimizations, examples of significant size can be handled. The proposed transducer iteration technique can just as well be exploited to compute the closure of a given set of states by the transducer iteration, which has proven to be a very effective way of using the technique. Examples such as a leaking gas burner in which time is modeled by real variables have been handled completely within the automata-theoretic setting. [less ▲]

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See detailAtteinte du nerf sus-scapulaire : corrélations entre l’évaluation isocinétique et l’ENMG
GOFFINET, Estelle ULg; Mazza, L; FORTHOMME, Bénédicte ULg et al

in Neurophysiologie Clinique = Clinical Neurophysiology (2004)

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See detailConfrontation anatomo-clinique. Mélanose vulvaire.
Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2004), 59(12), 731-3

Vulvar melanosis is a benign disorder that may suggest a malignant melanoma. We report the case of a woman in whom partial vulvectomy was performed to eradicate the melanotic macule. The lesion ... [more ▼]

Vulvar melanosis is a benign disorder that may suggest a malignant melanoma. We report the case of a woman in whom partial vulvectomy was performed to eradicate the melanotic macule. The lesion corresponds to increased accumulation of melanin inside keratinocytes in the absence of any melanocytic neoplasm. [less ▲]

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See detailA parasite reveals cryptic phylogeographic history of its host
Nieberding, caroline; Morand, Serge; Douady, Christopher et al

in Mas coma, P. (Ed.) Abstract book the IX EUROPEAN MULTICOLLOQUIUM OF PARASITOLOGY (2004)

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See detailOnce-monthly oral ibandronate a new bisphosphonate dosing concept
Reginster, Jean-Yves ULg; Miller, P.; Delmas, P. et al

in Calcified Tissue International (2004), 74(S1), 85

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See detailMyelome multiple et infection a VIH/SIDA : a propos de trois observations.
Elira Dokekias, A.; Moutschen, Michel ULg; Purhuence, M. F. et al

in Revue Médicale de Liège (2004), 59(2), 95-7

HIV infection rages at the endemic state in Sub Saharan African and especially in Congo Brazzaville. We report the observation of three female patients infected with HIV and developing multiple myeloma ... [more ▼]

HIV infection rages at the endemic state in Sub Saharan African and especially in Congo Brazzaville. We report the observation of three female patients infected with HIV and developing multiple myeloma. The three patients were treated at the University hospital of Brazzaville between 2000 and 2002. In two cases multiple myeloma was discovered after the diagnosis of HIV infection. In the other case, the diagnosis of HIV infection was posterior to the occurrence of multiple myeloma. HIV infection was symptomatic in two cases who received consequently antiviral treatment. Multiple myeloma was diagnosed at an advanced stage in the three cases. The paraprotein was an IgG in two cases and an IgA in the other one. The CD4 counts before treatment were around 200/mm3 in two cases and within normal limits in the third case. Viral load was not measured. VMCP and VAMCP regimens were administered without major complications and under anti-infectious prophylaxis. The follow-up is still insufficient to assess the medium-term evolution and to determine the prognosis of multiple myeloma. The description of these three cases confirms the involvement of HIV in B cell lymphoma genesis. [less ▲]

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See detailLe triphosphate de thiamine : une nouvelle molécule de signalisation ?
Bettendorff, Lucien ULg

Scientific conference (2004)

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See detailNovel surgical technique for the treatment of female stress urinary incontinence: Transobturator vaginal tape inside-out
de Leval, Jean ULg; Bonnet, Pierre ULg; Reul, Olivier ULg et al

Poster (2004)

Introduction and Objective: To describe a new, simple surgical technique for the treatment of female stress urinary incontinence (SUI) and to evaluate its feasibility. Methods: We have developed a novel ... [more ▼]

Introduction and Objective: To describe a new, simple surgical technique for the treatment of female stress urinary incontinence (SUI) and to evaluate its feasibility. Methods: We have developed a novel surgical treatment of SUI, the transobturator inside-out tension-free urethral suspension, which uses specifically designed surgical tools: a pair of stainless steel helical passers, two plastic tubes with a pointed distal end and one guide. Using these instruments, a synthetic tape is passed from underneath the urethra, through the obturator foramens, towards the thighs, without entering the pelvic region at any time during the procedure. The tubes bear a lateral opening, which allows the insertion of the helical passer into its lumen. The proximal end of each tube is attached to a non-absorbable synthetic tape. The guide acts as a shoe-horn to ease the introduction of the tubes assembled onto the helical passers from the perineal space through the obturator foramen. After perforation of the obturator membrane, a rotational movement of the helical passer around the upper part of ischio-pubic ramus allows the exit of the pointed tip of the tube and, further, of the tape at the level of the thigh on either side. The tape is positioned without tension under the junction between mid and distal urethra. Results: The procedure was carried out in 210 consecutive patients (mean age = 62 years) using the same operative protocol in all case subjects, independently of the patient’s size and weight. Mean operative time was 14 min (range = 6 to 20) in case of isolated SUI treatment. No bladder or urethra injury and no vascular (hematoma or bleeding) or neurological complication were observed. Conclusions: The results of this study indicate that our novel transobturator inside-out surgical technique for treating SUI is feasible, accurate, and quick. This technique avoids damage to the urethra and bladder and, therefore, makes cystoscopy not necessary. Further prospective studies are currently ongoing to determine the efficacy of our new surgical approach for treating SUI. [less ▲]

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See detailImage-guided neurosurgery ...
Verly, Jacques ULg

Scientific conference (2004)

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See detailLandscape metrics for the evaluation of trend reliability in remote sensing imagery.
Bogaert, Jan ULg

in Abstracts of the Second International SPOT/VEGETATION Users Conference (2004)

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See detailLe décasyllabe de Marie Étienne et son écriture générale (Anatolie, 1997)
Purnelle, Gérald ULg

in Formes Poétiques Contemporaines (2004), 2

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See detailIcon with the Virgin Hodegetria
George, Philippe ULg

in Catalogue de l'exposition Byzantium : Faith and Power (1261-1557), p. 252-253. (2004)

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See detailLe Haricot-igname Africain (Sphenostylis stenocarpa (Hochst. ex A. Rich.) Harms) : une légumineuse à graines et à tubercules sous-exploitée
Baudoin, Jean-Pierre ULg; Kamion Ngansia, F.

in Troupeaux et Cultures des Tropiques (2004), II(IV), 44-46

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See detailThe Articulation of “I”, “We” and the “Person”. Elements for an Anthropological Approach within Western and Islamic Contexts
Nachi, Mohamed ULg

in DUPRET, Baudouin (Ed.) Standing Trial. Law and the Person in the Modern Middle East (2004)

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