References of "2004"
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See detailContact and photocontact allergy to ketoprofen. The Belgian experience.
Matthieu, L.; Meuleman, L.; Van Hecke, E. et al

in Contact Dermatitis (2004), 50(4), 238-241

Topical ketoprofen (KP) is widely used because of its anti-inflammatory effect. However, photocontact dermatitis is a side-effect. Between May 2001 and June 2002, the Belgian Contact & Environmental ... [more ▼]

Topical ketoprofen (KP) is widely used because of its anti-inflammatory effect. However, photocontact dermatitis is a side-effect. Between May 2001 and June 2002, the Belgian Contact & Environmental Dermatitis Group conducted a prospective, open patch and photopatch test study in 20 patients suspected of KP dermatitis. Severe skin symptoms requiring systemic corticotherapy occurred in 47%. 5 patients were hospitalized. 1 patient showed prolonged photosensitivity. All patients were tested with KP and the other constituents of KP gel. Attribution to KP was demonstrated in all cases. Patch and photopatch tests with KP 2% in petrolatum showed contact photoallergy in 17 patients, contact allergy in 1 patient and photoaggravated contact allergy in 2 patients. 5 patients also reacted to the fragrance components lavender (Lavandula augustifolia) oil and/or neroli (Citrus aurantium dulcis) oil 5% in alcohol. However, in 4 of these, irritant reactions to the ethanolic dilutions could not be ruled out. Additional tests with 3 non-steroidal anti-inflammatory drugs without benzophenone structure ibuprofen, naproxen and diclofenac identified only 1 contact allergic reaction to diclofenac. Cross-reactivity to the substituted benzophenones, oxybenzone and sulisobenzone occurred only to the first in less than 30% of the patients. A high frequency (69%) of contact allergy to fragrance mix was found. Dermatologists should be aware of the severity of photoallergic reactions to KP and the risk of cross-sensitization. [less ▲]

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See detailLe troisième corps
Delville, Michel ULg

Book published by Le Fram (2004)

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See detailPurification and characterization of glutathione S-transferases from two syrphid flies (Syrphus ribesii and Myathropa florae).
Vanhaelen, Nicolas; Francis, Frédéric ULg; Haubruge, Eric ULg

in Comparative Biochemistry & Physiology Part B (2004), 137(1), 95-100

Glutathione S-transferases (GST) play an important role in the detoxification of many substances including organic pollutants and plant secondary metabolites. We compared the GST of two syrphid species ... [more ▼]

Glutathione S-transferases (GST) play an important role in the detoxification of many substances including organic pollutants and plant secondary metabolites. We compared the GST of two syrphid species, the aphidophagous Syrphus ribesii and the saprophagous Myathropa florea to assess the relation between feeding type and GST patterns. Differences between the GST of the hoverfly species were observed after purification by affinity chromatography, SDS-PAGE and kinetic studies. While the specific activities of the purified enzymes were different, the purification yields were similar. The variation in specific activities was related to the presence of different isoenzymes in both syrphid species by SDS-PAGE. While two bands of 24 and 32 kDa were observed for M. florea, one more band of 26 kDa was present in S. ribesii. When a range of substrate and glutathione concentrations was tested, differences in Km and Vmax between the glutathione S-transferases from both hoverfly species were also observed. These results are discussed in terms of adaptations to the feeding habit and the habitat of the two syrphid species. [less ▲]

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See detailGrass disease et Equine motor neurone disease
Amory, Hélène ULg

in Proceedings of 2ème Journée Toulousaine de Médecine Equine (2004)

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See detailCurrent status of transmissible spongiform encephalopathies in ruminants
Thiry, Etienne ULg; Saegerman, Claude ULg; Xambeu, Laurence et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2004), 8

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See detailCatalogue des post-incunables conservés à la Bibliothèque royale de Belgique
Adam, Renaud ULg

E-print/Working paper (2004)

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See detailA Consistent Dissipative Time Integration Scheme for Structural Dynamics. Application to Rotordynamics.
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg

(2004)

Recently, robust implicit energy and momentum conserving algorithms have been developed in the non-linear range. In previous works, the authors extended these algorithms to hypoelasticity-based ... [more ▼]

Recently, robust implicit energy and momentum conserving algorithms have been developed in the non-linear range. In previous works, the authors extended these algorithms to hypoelasticity-based constitutive models. In this paper we introduce numerical dissipation, opening the way to more complex simulations such as blade-loss in a turbofan. [less ▲]

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See detailLa santé mentale, champ pertinent de l'action sociale
Vrancken, Didier ULg

Article for general public (2004)

Le champ de la santé mentale est devenu un secteur particulièrement pertinent pour étudier les évolutions en matière d’aide sociale et d’intervention sur les personnes.

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See detailMeasurement of mammalian histone deacetylase activity.
Verdin, Eric; Dequiedt, Franck ULg; Fischle, Wolfgang et al

in Methods in Enzymology (2004), 377

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See detailResponders to glucosamine sulfate in knee osteoarthritis
Bruyère, Olivier ULg; Pavelka, K.; Richy, F. et al

in Osteoporosis International (2004), 12(SB), 76

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See detailLck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH.
Alonso, Andres; Bottini, Nunzio; Bruckner, Shane et al

in Journal of Biological Chemistry (2004), 279(6), 4922-8

A key virulence factor for Yersinia pestis, the etiologic agent of plague, is the tyrosine phosphatase YopH, which the bacterium injects into host cells. We report that treatment of human T lymphocytes ... [more ▼]

A key virulence factor for Yersinia pestis, the etiologic agent of plague, is the tyrosine phosphatase YopH, which the bacterium injects into host cells. We report that treatment of human T lymphocytes with a recombinant membrane-permeable YopH resulted in severe reduction in intracellular tyrosine phosphorylation and inhibition of T cell activation. The primary signal transducer for the T cell antigen receptor, the Lck tyrosine kinase, was specifically precipitated by a substrate-trapping YopH mutant, and Lck was dephosphorylated at its positive regulatory site, Tyr-394, in cells containing active YopH. By turning off Lck, YopH blocks T cell antigen receptor signaling at its very first step, effectively preventing the development of a protective immune response against this lethal bacterium. [less ▲]

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See detailLa révolution internet
Choffray, Jean-Marie ULg

in Bair J. et V. Henry (Ed.) Regards Croisés sur les Méthodes Quantitatives de Gestion (2004)

Les technologies internet constituent-elles une simple étape ou bien une profonde révolution dans l’évolution des savoirs et pratiques de management ? L’objet de cet article est de présenter le fruit de ... [more ▼]

Les technologies internet constituent-elles une simple étape ou bien une profonde révolution dans l’évolution des savoirs et pratiques de management ? L’objet de cet article est de présenter le fruit de plusieurs années d’observation et de réflexion sur le nouvel espace de liberté auquel conduit l’adoption généralisée d’internet. Après avoir évalué le degré de maturité de ce secteur au travers de la performance de quelques acteurs représentatifs, nous décrivons l’incidence de ces technologies sur des dimensions telles que l’information, l’éducation, le commerce, l’investissement et l’industrie. Enfin, nous évoquons quelques pistes de développement futur et les opportunités qui y sont associées. [less ▲]

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See detailEffects of a quantitative trait locus for muscle hypertrophy from Belgian Texel sheep on carcass conformation and muscularity
Laville, E.; Bouix, J.; Sayd, T. et al

in Journal of Animal Science (2004), 82(11), 3128-3137

A QTL for muscle hypertrophy has been identified in the Belgian Texel breed. A population of F-2 and backcross lambs created from crosses of Belgian Texel rams with Romanov ewes was studied. Effects on ... [more ▼]

A QTL for muscle hypertrophy has been identified in the Belgian Texel breed. A population of F-2 and backcross lambs created from crosses of Belgian Texel rams with Romanov ewes was studied. Effects on carcass traits and muscle development of the Belgian Texel breed polygenes and Belgian Texel single QTL were compared. In both cases, carcass conformation and muscularity were improved. The Texel polygenic environment improved conformation mainly through changes in skeletal frame shape. Segments were shorter and bone weight lower. Muscles were more compact, shorter, and thicker. The single QTL affected muscle development. Thickness and weight of muscles were increased. Composition in myosin changed toward an increase of fast contractile type. The relative contribution of hind limb joint to carcass weight was increased. Differences in skeletal frame morphology among the three genotypes of the single QTL were small. Conformation scoring was mainly influenced by leg muscularity. Back and shoulder muscle development, which largely contributed to variability of muscularity, were less involved in the conformation scoring. Lastly, the QTL explains a small part of differences between these Belgian Texel and Romanov breeds for conformation or muscle development. A large part of genetic variability remains to be explored. [less ▲]

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See detailEpidemiology and outcome of acute lung injury in European intensive care units. Results from the ALIVE study
Brun-Buisson, Christian; Minelli, Cosetta; Bertolini, Guido et al

in Intensive Care Medicine (2004), 30(1), 51-61

Abstract Objectives: To re-examine the epidemiology of acute lung injury (ALI) in European intensive care units (ICUs). Design and setting: A 2-month inception cohort study in 78 ICUs of 10 European ... [more ▼]

Abstract Objectives: To re-examine the epidemiology of acute lung injury (ALI) in European intensive care units (ICUs). Design and setting: A 2-month inception cohort study in 78 ICUs of 10 European countries. Patients: All patients admitted for more than 4 h were screened for ALI and followed up to 2 months. Measurements and main results: Acute lung injury occurred in 463 (7.1%) of 6,522 admissions and 16.1% of all mechanically ventilated patients; 65.4% cases occurred on ICU admission. Among 136 patients initially presenting with “mild ALI” (200< PaO2/FiO2 £300), 74 (55%) evolved to acute respiratory distress syndrome (ARDS) within 3 days. Sixty-two patients (13.4%) remained with mild ALI and 401 had ARDS. The crude ICU and hospital mortalities were 22.6% and 32.7% (p<0.001), and 49.4% and 57.9% (p=0.0005), respectively, for mild ALI and ARDS. ARDS patients initially received a mean tidal volume of 8.3±1.9 ml/kg and a mean PEEP of 7.7±3.6 cmH2O; air leaks occurred in 15.9%. After multivariate analysis, mortality was associated with age (odds ratio (OR) =1.2 per 10 years; 95% confidence interval (CI): 1.05–1.36), immuno-incompetence (OR: 2.88; Cl: 1.57–5.28), the severity scores SAPS II (OR: 1.16 per 10% expected mortality; Cl: 1.02–1.31) and logistic organ dysfunction (OR: 1.25 per point; Cl: 1.13–1.37), a pH less than 7.30 (OR: 1.88; Cl: 1.11–3.18) and early air leak (OR: 3.16; Cl: 1.59–6.28). Conclusions: Acute lung injury was frequent in our sample of European ICUs (7.1%); one third of patients presented with mild ALI, but more than half rapidly evolved to ARDS. While the mortality of ARDS remains high, that of mild ALI is twice as low, confirming the grading of severity between the two forms of the syndrome. [less ▲]

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See detailTransmission of CARD15 (NOD2) variants within families of patients with inflammatory bowel disease.
Esters, Nele; Pierik, Marie; Van Steen, Kristel ULg et al

in American Journal of Gastroenterology (2004), 99(2), 299-305

OBJECTIVES: Three single nucleotide polymorphisms (SNPs) in CARD15 have been independently associated with Crohn's disease (CD). Since nothing is known about the transmission of these variants within ... [more ▼]

OBJECTIVES: Three single nucleotide polymorphisms (SNPs) in CARD15 have been independently associated with Crohn's disease (CD). Since nothing is known about the transmission of these variants within families, this was the subject of our study in Flemish patients with inflammatory bowel disease (IBD) and their healthy relatives. METHODS: A cohort of 1,670 individuals (570 CD, 173 UC, 165 healthy controls, 762 first-degree unaffected relatives of CD patients) was genotyped for Arg702Trp, Gly908Arg, and Leu1007fsinsC. Mutant allele and carrier frequencies were compared between groups. Segregation patterns were compared using a bivariate Dale model. RESULTS: The carrier prevalence of CARD15 variants for CD patients was 46.3%, compared to 20.6% for healthy controls and 22.0% for ulcerative colitis (UC) patients (both p < 0.0001). An increased carriage rate of CARD15 variants was observed in unaffected relatives of CD patients (37.3%; p < 0.0001 vs controls), although this was significantly lower than in the CD patients (p = 0.001). Paternal transmission gave a 5.17-fold higher chance for the child to develop the disease compared to maternal transmission (95% CI [1.59, 16.78]; p = 0.0063). UC patients belonging to mixed IBD families carried significantly more mutations (42.3%) compared to other UC patients (18.4%) (p < 0.01). CONCLUSIONS: Maternal transmission of the CARD15 variant allele is associated with a lower proportion of affected individuals compared to paternal transmission. Therefore, maternal transmission does not carry an increased risk of transmission as does paternal transmission. The increased mutation carriage in unaffected siblings of CD patients and in UC patients belonging to mixed families suggests that other factors than CARD15 contribute to the eventual disease expression. [less ▲]

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See detailUse of pregnancy specific proteins, P4, PGFM and E1S assays to monitor pregnancy in sheep
Gajewski, Z.; Beckers, Jean-François ULg; Melo de Sousa, Noelita ULg et al

in Reproduction in Domestic Animals (2004), 39(4), 288

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See detailL’émergence du concept d’entreprise sociale
Defourny, Jacques ULg

in Reflets et Perspectives de la Vie Economique (2004), XLIII(3), 9-23

This paper tries to show how the concept of social enterprise is increasingly used in many countries. In Europe, the most significant steps have been taken by the Italian parliament in the early 90’s and ... [more ▼]

This paper tries to show how the concept of social enterprise is increasingly used in many countries. In Europe, the most significant steps have been taken by the Italian parliament in the early 90’s and since 2002 by the UK government which has decided to map and promote social enterprises. From a scientific point of view, the approach built by the EMES European Research Network, based on comparative research in all EU countries, provides a solid basis for further theoretical and empirical work as well as new insights into the whole social economy. [less ▲]

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