References of "2004"
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See detail"L'Egypte gréco-romaine révélée par les papyrus" : L'esclave (Recueil de documents papyrologiques)
Straus, Jean ULg

Book published by Université de Liège. Sciences de l'Antiquité. Langues et littératures classiques (2004)

A selection of 12 papyrological documents relative to slavery in Graeco-Roman Egypt (text, critical apparatus, translation, bibliography).

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See detailPassive energy transfer and dissipation for isolation from transcient broadband disturbances
Kerschen, Gaëtan ULg; McFarland, D. Michael; Kowtko, J. et al

in US-Korea Joint Seminar/Workshop on Smart Structures Technologies, Seoul, 2004 (2004)

We discuss passive nonlinear energy pumping from a linear (main) mechanical structure to a weakly coupled, local, passive nonlinear energy sink (NES). We show that the NES can be designed to effectively ... [more ▼]

We discuss passive nonlinear energy pumping from a linear (main) mechanical structure to a weakly coupled, local, passive nonlinear energy sink (NES). We show that the NES can be designed to effectively absorb vibrational energy from the main structure in a one-way, irreversible fashion. We demonstrate the occurrence of pumping cascades, where an appropriately designed NES passively extracts energy sequentially from a number of modes of the main (linear) structure, interacting individually with each mode before moving to the next. Experimental results confirm our theoretical findings. The applications of the nonlinear energy pumping phenomenon to the problem of vibration and shock isolation will be discussed [less ▲]

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See detailLes arts au Moyen Age
George, Philippe ULg

in Demoulin, Bruno; Kupper, Jean-Louis (Eds.) Histoire de la Wallonie (2004)

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See detailCaspase-8-dependent HER-2 cleavage in response to tumor necrosis factor alpha stimulation is counteracted by nuclear factor kappa B through c-FLIP-L expression
Benoit, Valérie; Chariot, Alain ULg; Delacroix, Laurence ULg et al

in Cancer Research (2004), 64(8), 2684-2691

The oncoprotein HER-2/neu is a prosurvival factor, and its overexpression has been correlated with poor prognosis in patients with breast cancer. We report that HER-2 is a new substrate for caspase-8 and ... [more ▼]

The oncoprotein HER-2/neu is a prosurvival factor, and its overexpression has been correlated with poor prognosis in patients with breast cancer. We report that HER-2 is a new substrate for caspase-8 and that tumor necrosis factor alpha (TNF-alpha) stimulation leads to an early caspase-8-dependent HER-2 cleavage in MCF7 A/Z breast adenocarcinoma cells defective for nuclear factor kappaB (NFkappaB) activation. We show that the antiapoptotic transcription factor NFkappaB counteracts this cleavage through induction of the caspase-8 inhibitor c-FLIP. Our results also demonstrate that this HER-2 cleavage contributes to the TNF-alpha-induced apoptosis pathway because ectopic expression of an uncleavable HER-2 protects NFkappaB-defective cells against TNF-alpha-mediated cell death. Therefore, we propose an original model in which NFkappaB exerts a new antiapoptotic function by counteracting TNF-alpha-triggered cleavage of the HER-2 survival factor. [less ▲]

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See detailPreparation and in vivo toxicity study of solid lipid microparticles as carrier for pulmonary administration
Sanna, V.; Kirschvink, Nathalie; Gustin, Pascal ULg et al

in AAPS PharmScitech (2004), 5(2), 27

The purpose of this research was to investigate the effects of processing conditions on the characteristics of solid lipid microparticles (SLM) with a potential application as carriers for pulmonary ... [more ▼]

The purpose of this research was to investigate the effects of processing conditions on the characteristics of solid lipid microparticles (SLM) with a potential application as carriers for pulmonary administration. Compritol ( 5.0% wt/ wt) SLM dispersions were prepared by rotor-stator homogenization, at different surfactant concentrations and emulsification times. The SLM were characterized, in terms of morphology and size, after lyophilization and sterilization by autoclaving process. In vivo assessment was carried out in rats by intratracheal instillation of either placebo or SLM dispersion, and by bronchoalveolar lavage for cytological analysis. Mean particle size of 4 to 5 mum was achieved using 0.3% and 0.4% ( wt/ wt) of emulsifier ( Poloxamer 188) and emulsification times of 2 and 5 minutes. The particles showed spherical shape and smooth surface. The morphology of microparticles, the size, and the size distribution were not substantially modified after lyophilization and sterilization. Total cell counts showed no significant differences between placebo and SLM 0.5% or 2.5% groups. Regarding cytology, percentage of polymorphonuclear neutrophils and macrophages did not significantly differ between groups. These results suggest that a single intratracheal administration of the SLMs does not induce a significant inflammatory airway response in rats and that the SLMs might be a potential carrier for encapsulated drug via the pulmonary route. [less ▲]

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See detailDiscriminative stimulus effects of ethanol: Lack of interaction with taurine
Quertemont, Etienne ULg; Grant, Kathleen A.

in Behavioural Pharmacology (2004), 15(7), 495-501

Recent microdialysis studies showed that ethanol administration increases the release of taurine in various rat brain regions, and it was suggested that this increase in extracellular concentrations of ... [more ▼]

Recent microdialysis studies showed that ethanol administration increases the release of taurine in various rat brain regions, and it was suggested that this increase in extracellular concentrations of taurine might mediate some of the neurochemical effects of ethanol. Previous drug discrimination studies showed that positive modulators of the GABA(A) receptor consistently substituted for ethanol discriminative stimulus effects. Since taurine is also believed to modulate GABA(A) receptor activity, this study addressed the hypothesis that taurine mediates the discriminative stimulus effects of ethanol due to GABA(A) activation. Male Long-Evans rats were trained to discriminate water from either 1 or 2 g/kg ethanol. In a first experiment, various taurine doses (0-500 mg/kg) were tested to investigate whether taurine substitutes for ethanol. In a second experiment, rats were pretreated with either 500 mg/kg taurine or an equivalent volume of saline before testing for ethanol discrimination with various ethanol doses (0-2.0 g/kg). The results showed that taurine does not substitute for ethanol at any tested doses. In addition, taurine pretreatments failed to modify the dose-response curve for ethanol discrimination. These results demonstrate that taurine is not directly involved in mediating the discriminative stimulus effects of ethanol. It is therefore very unlikely that the brain release of taurine observed after ethanol administration is implicated in the major pharmacological effects of ethanol, i.e. positive modulation of GABA(A) receptor, that mediate its discriminative stimulus effects. [less ▲]

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See detailThe genus Iowatrypa Copper, 1973 (Brachiopoda) in the Les Valisettes Formation (late Frasnian of the Philippeville Anticlinorium, southern Belgium)
Mottequin, Bernard ULg

in Bulletin de l'Institut Royal des Sciences Naturelles de Belgique. Sciences de la Terre (2004), 74

A new species of the genus Iowatrypa Copper, 1973 [I. philippevillensis n. sp. (Pseudogruenewaldtiinae)] is described from the late Frasnian (Upper Palmatolepis rhenana Zone) Les Valisettes Formation ... [more ▼]

A new species of the genus Iowatrypa Copper, 1973 [I. philippevillensis n. sp. (Pseudogruenewaldtiinae)] is described from the late Frasnian (Upper Palmatolepis rhenana Zone) Les Valisettes Formation (Philippeville Anticlinorium). [less ▲]

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See detailExperimental characterization of hafting traces and their recognition in archaeological assemblages
Rots, Veerle ULg; Vermeersch, Pierre M.

in Walker, E. A.; Wenban-Smith, F.; Healy, F. (Eds.) Lithics in Action. Papers from the Conference Lithic Studies in the Year 2000 (2004)

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See detailComparison of steam and nitrogen in the physical deacidification of soybean oil
Decap, Philippe; Danthine, Sabine ULg; Vanbrabant, Béatrice et al

in Journal of the American Oil Chemists' Society [=JAOCS] (2004), 81(6), 611-617

Deacidification in physical refining is one of the most sensitive steps in refining edible vegetable oils because of its large impact on the quality of the oil. The removal of volatile compounds such as ... [more ▼]

Deacidification in physical refining is one of the most sensitive steps in refining edible vegetable oils because of its large impact on the quality of the oil. The removal of volatile compounds such as FFA is accomplished at elevated temperatures and a high vacuum with a stripping gas, usually steam. The aim of this work was to verify, at the laboratory level, the advantages of using an alternative stripping gas, nitrogen, instead of steam. An ideal vapor-liquid equilibrium model (lVLE) was used to compare the stripping capacities of steam and nitrogen and to analyze the effects of various operational parameters (temperature, pressure, amount of stripping gas) on the residual acidity of the oil. There was no clear evidence that nitrogen showed a higher capacity to strip FFA than steam. The IVLE model seemed suitable to describe FFA laboratory distillation by using steam or nitrogen, provided the final residual content of FFA was not too low. [less ▲]

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See detailMUNE in the last 30 years: what can we expect of it in practice?
WANG, François-Charles ULg; GERARD, Pascale ULg; BOUQUIAUX, Olivier ULg

in Correspondances en Nerf & Muscle (2004)

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See detailMeasure Noun constructions: degrees of delexicalization and grammaticalization
Brems, Lieselotte ULg

in Advances in corpus linguistics: Papers from the 23rd International Conference on English Language Research on Computerized Corpora (ICAME 23). (2004)

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See detailAnalyse critique des techniques d'estimation du nombre d'unites motrices.
Wang, François-Charles ULg; Gerard, Pascale ULg; Bouquiaux, Olivier ULg

in Revue Médicale de Liège (2004), 59 Suppl 1

It is now 30 years since the first motor unit number estimation (MUNE) technique was introduced by Allan McComas as a way of providing an objective, sensitive and reproducible means of measuring the ... [more ▼]

It is now 30 years since the first motor unit number estimation (MUNE) technique was introduced by Allan McComas as a way of providing an objective, sensitive and reproducible means of measuring the number of motor axons in living human muscle or muscle group. MUNE techniques have substantially evolved over the past decade and have been applied, with increasing frequency, to the study of age effects on motoneurone population and muscle denervating disorders such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy, poliomyelitis and different types of inherited and acquired peripheral neuropathies. In the future, one of the most important topics involving MUNE, will probably be its use in monitoring the progress of ALS patients undergoing experimental drug trials. However, among incremental, multiple point stimulation, spike-triggered averaging, F-wave analysis and statistical methods, there is no consensus about the best MUNE method. There is only a general feeling that some techniques are more valid than others. For this reason, in the present review, brief descriptions of the distinct MUNE methods are presented. In the second part of the paper, advantages and limitations (alternation, sampling errors, temporal registration etc...) of the most commonly employed procedures are considered. [less ▲]

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See detailLandscape pattern analysis using independent pattern components and landscape transformation processes.
Bogaert, Jan ULg

in The 19th Annual Symposium of the IALE US regional association. (2004)

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See detailLocalizable effective theories, bootstrap and the parameters of hadron resonances
Semenov-Tyan-Shanskiy, Kirill ULg; Vereshagin, Alexander; Vereshagin, Vladimir

in AIP Conference Proceedings (2004), 717

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See detailL'image du mois. Un courant d'air.
ROUSSEAU, Anne-Françoise ULg; CANIVET, Jean-Luc ULg; CAMPOLINI, Christophe

in Revue Médicale de Liège (2004), 59(10), 550-551

Portal venous gas is a rare radiological symptom related to several possible causes. Its severity is only correlated with the severity of the primary disease. We report the case of a portal pneumatose ... [more ▼]

Portal venous gas is a rare radiological symptom related to several possible causes. Its severity is only correlated with the severity of the primary disease. We report the case of a portal pneumatose. The diagnosis was made by ultrasound and CT scan. [less ▲]

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See detailCardiomyocyte-restricted overexpression of endothelial nitric oxide synthase (NOS3) attenuates beta-adrenergic stimulation and reinforces vagal inhibition of cardiac contraction.
MASSION, Paul ULg; Dessy, Chantal; Desjardins, Fanny et al

in Circulation (2004), 110(17), 2666-72

BACKGROUND: In the heart, nitric oxide synthases (NOS) modulate cardiac contraction in an isoform-specific manner, which is critically dependent on their cellular and subcellular localization. Defective ... [more ▼]

BACKGROUND: In the heart, nitric oxide synthases (NOS) modulate cardiac contraction in an isoform-specific manner, which is critically dependent on their cellular and subcellular localization. Defective NO production by NOS3 (endothelial NOS [eNOS]) in the failing heart may precipitate cardiac failure, which could be reversed by overexpression of NOS3 in the myocardium. METHODS AND RESULTS: We studied the influence of NOS3 in relation to its subcellular localization on the function of cardiomyocytes isolated from transgenic mice overexpressing NOS3 under the alpha-myosin heavy chain promoter (NOS3-TG). Immunoblot analysis demonstrated moderate (5-fold) NOS3 overexpression in cardiomyocytes from NOS3-TG heterozygotes. Caveolar localization of transgenic eNOS was demonstrated by immunofluorescence, coimmunoprecipitation with caveolin-3, sucrose gradient fractionation, and immunogold staining revealed by electron microscopy. Compared with wild-type littermate, contractility of NOS3-TG cardiomyocytes analyzed by videomicroscopy revealed a lower incidence of spontaneous arrhythmic contractions (n=32, P<0.001); an attenuation of the beta-adrenergic positive inotropic response (isoproterenol, 10(-7) mol/L: 62.1+/-7.8% versus 90.8+/-8.0% of maximum Ca2+ response; n=10 to 17; P<0.05); a potentiation of the muscarinic negative chronotropic response (carbamylcholine, 3.10(-8) mol/L: -63.9+/-14% versus -27.7+/-5.6% of basal rate; n=8 to 10; P<0.05), confirmed by telemetry in vivo; and an attenuation of the accentuated antagonism of beta-adrenergically stimulated contraction (-14.6+/-1.5% versus -3.5+/-1.5; n=7 to 11; P<0.05). Cardiomyocyte NOS inhibition reversed all 4 effects (P<0.05). CONCLUSIONS: Moderate overexpression of NOS3, targeted to caveolae in murine cardiomyocytes, potentiates the postsynaptic muscarinic response and attenuates the effect of high concentrations of catecholamines. Cardiomyocyte NOS3 may represent a promising therapeutic target to restore the sympathovagal balance and protect the heart against arrhythmia. [less ▲]

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