References of "2004"
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See detailGibberellins and the floral transition in Sinapis alba
Corbesier, Laurent; Kustermans, Gaëlle ULg; Périlleux, Claire ULg et al

in Physiologia Plantarum (2004), 122(1), 152-158

The putative role of gibberellins in the transition to flowering was investigated in Sinapis alba, a caulescent long-day (LD) plant. It was observed that: (1) physiological doses of exogenous gibberellins ... [more ▼]

The putative role of gibberellins in the transition to flowering was investigated in Sinapis alba, a caulescent long-day (LD) plant. It was observed that: (1) physiological doses of exogenous gibberellins (GA(1), GA(3), GA(9)) do not cause the floral shift of the meristem when applied to plants grown in short days but have some positive effect on the flowering response to a suboptimal LD; no inhibition was observed in any case; (2) GA-biosynthesis inhibitors (prohexadione-Ca and paclobutrazol) considerably inhibit stem growth but have some negative effect on flowering only when a suboptimal LD is given; and (3) the floral transition induced by one 22-h LD does not correlate with any detectable change in GA content of the apical bud, of the leaves, and of the phloem exudate reaching the apex. Taken together, these results suggest that GAs do not act as a major signal for photoperiodic flower induction in Sinapis. [less ▲]

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See detailThe morality in/of compromise: some
Nachi, Mohamed ULg

in Social Science Information/Information sur les sciences sociales (2004), 43(2), 291-305

This article aims to highlight the position occupied by compromise in the field of ethics. The argument is set out in two stages. First, the author attempts to clarify the contours of compromise by ... [more ▼]

This article aims to highlight the position occupied by compromise in the field of ethics. The argument is set out in two stages. First, the author attempts to clarify the contours of compromise by treating it as both a procedure or process of conflict resolution and a goal or ‘‘solution’’ to be achieved. In the second stage, he examines the distinction that could be made between ‘‘morality in compromise’’ and ‘‘morality of compromise’’, so as to measure its import and show how compromise not only contains elements specific to morality as a system but can also be a form of morality in itself. [less ▲]

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See detailLes arts au Moyen Age
George, Philippe ULg

in Demoulin, Bruno; Kupper, Jean-Louis (Eds.) Histoire de la Wallonie (2004)

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See detailL’émergence du concept d’entreprise sociale
Defourny, Jacques ULg

in Reflets et Perspectives de la Vie Economique (2004), XLIII(3), 9-23

This paper tries to show how the concept of social enterprise is increasingly used in many countries. In Europe, the most significant steps have been taken by the Italian parliament in the early 90’s and ... [more ▼]

This paper tries to show how the concept of social enterprise is increasingly used in many countries. In Europe, the most significant steps have been taken by the Italian parliament in the early 90’s and since 2002 by the UK government which has decided to map and promote social enterprises. From a scientific point of view, the approach built by the EMES European Research Network, based on comparative research in all EU countries, provides a solid basis for further theoretical and empirical work as well as new insights into the whole social economy. [less ▲]

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See detailCaspase-8-dependent HER-2 cleavage in response to tumor necrosis factor alpha stimulation is counteracted by nuclear factor kappa B through c-FLIP-L expression
Benoit, Valérie; Chariot, Alain ULg; Delacroix, Laurence ULg et al

in Cancer Research (2004), 64(8), 2684-2691

The oncoprotein HER-2/neu is a prosurvival factor, and its overexpression has been correlated with poor prognosis in patients with breast cancer. We report that HER-2 is a new substrate for caspase-8 and ... [more ▼]

The oncoprotein HER-2/neu is a prosurvival factor, and its overexpression has been correlated with poor prognosis in patients with breast cancer. We report that HER-2 is a new substrate for caspase-8 and that tumor necrosis factor alpha (TNF-alpha) stimulation leads to an early caspase-8-dependent HER-2 cleavage in MCF7 A/Z breast adenocarcinoma cells defective for nuclear factor kappaB (NFkappaB) activation. We show that the antiapoptotic transcription factor NFkappaB counteracts this cleavage through induction of the caspase-8 inhibitor c-FLIP. Our results also demonstrate that this HER-2 cleavage contributes to the TNF-alpha-induced apoptosis pathway because ectopic expression of an uncleavable HER-2 protects NFkappaB-defective cells against TNF-alpha-mediated cell death. Therefore, we propose an original model in which NFkappaB exerts a new antiapoptotic function by counteracting TNF-alpha-triggered cleavage of the HER-2 survival factor. [less ▲]

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See detailOrigine biogénétique des triterpènes pentacycliques présents dans la sécrétion défensive de Platyphora kollari
Ghostin, Jean; Laurent, Pascal ULg; Daloze, Désiré et al

Poster (2004)

Les chrysomèles sont des insectes phytophages brillement colorés qui représentent une des famille (Chrysomelidae) les plus importante de l'ordre des coléoptères. Etant aposématiques, ils sont facilement ... [more ▼]

Les chrysomèles sont des insectes phytophages brillement colorés qui représentent une des famille (Chrysomelidae) les plus importante de l'ordre des coléoptères. Etant aposématiques, ils sont facilement repérables par des prédateurs potentiels et ont, au cours de l'évolution, développé des mécanismes de défense chimique élaborés. La découverte de glycosides triterpéniques basés sur le squelette oléanane a soulevé le problème de leur origine biogénétique. En effet, il est bien connu que les insectes ne possèdent pas la squalène synthase, une enzyme indispensable à la formation des stéroïdes et des triterpènes pentacycliques. Dès lors, une biosynthèse de novo de ce type de dérivé est peu probable. Par ailleurs, l'analyse de la plante hôte des chrysomèles a montré que la séquestration des glycosides au départ de cette plante est également exclue. Une troisième possibilité serait que l'insecte utilise un précurseur provenant de son alimentation pour fabriquer ses substances défensives. Un tel précurseur pourrait être la b-amyrine identifiée chez différentes plantes hôtes des chrysomèles ou l'acide oléanolique dont la structure de base se retrouve au niveau des triterpènes défensifs. Enfin, l'analyse des plantes hôtes a montré que celles-ci contiennent à la fois de la b-amyrine et de l'a-amyrine dans un rapport 1,76/1. Cependant aucun glycoside triterpénique basé sur le squelette ursane n'a été isolé jusqu'à présent chez les chrysomèles, ce qui suggère un mécanisme de transport sélectif en faveur de la b-amyrine. Dans le cadre de ce travail, nous présenterons les synthèses d'a-amyrine, de b-amyrine et d'acide oéanolique trideutériés, ainsi que les résultats d'incorporation des deux premiers précurseurs chez Platyphora kollari. [less ▲]

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See detailThe membrane form of the DNA repair protein Ku interacts at the cell surface with metalloproteinase 9.
Monferran, Sylvie; Paupert, Jenny ULg; Dauvillier, Stephanie et al

in The EMBO journal (2004), 23(19), 3758-68

The Ku heterodimer (Ku70/Ku80) plays a central role in DNA double-strand breaks repair. Ku is also expressed on the cell surface of different types of cells where its function remains poorly understood ... [more ▼]

The Ku heterodimer (Ku70/Ku80) plays a central role in DNA double-strand breaks repair. Ku is also expressed on the cell surface of different types of cells where its function remains poorly understood. From a yeast two-hybrid screen, we have identified a specific interaction between the core region of Ku80 and the hemopexin domain of metalloproteinase 9 (MMP-9), a key enzyme involved in the degradation of extracellular matrix (ECM) components. Ku associates with MMP-9 on the surface of leukemic cells as demonstrated by co-immunoprecipitation experiments in membrane extracts and double-label immunofluorescence studies. In normal and tumoral migratory cells, Ku80 and MMP-9 colocalize at the periphery of leading edge of cells and cellular invasion of collagen IV matrices was blocked by antibodies directed against Ku70 or Ku80 subunits as well as by Ku80-specific antisense oligonucleotides. Our results indicate that Ku and MMP-9 interact at the cell membrane of highly invasive hematopoietic cells of normal and tumoral origin and document the unexpected importance of the membrane-associated form of Ku in the regulation of ECM remodelling. [less ▲]

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See detailLipids metabolism and hyperlipidaemia in the dog
Jeusette, Isabelle; Istasse, Louis ULg; Diez, Marianne ULg

in Annales de Médecine Vétérinaire (2004), 148(2), 79-89

This synthesis aims to summarize lipids metabolism in the dog. The different aetiology and diagnostic of primary or secondary hyperlipidaemia in dog are reviewed. The nutritional treatment and more ... [more ▼]

This synthesis aims to summarize lipids metabolism in the dog. The different aetiology and diagnostic of primary or secondary hyperlipidaemia in dog are reviewed. The nutritional treatment and more particularly the use of dietary fibres are discussed. [less ▲]

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See detailComparison of steam and nitrogen in the physical deacidification of soybean oil
Decap, Philippe; Danthine, Sabine ULg; Vanbrabant, Béatrice et al

in Journal of the American Oil Chemists' Society [=JAOCS] (2004), 81(6), 611-617

Deacidification in physical refining is one of the most sensitive steps in refining edible vegetable oils because of its large impact on the quality of the oil. The removal of volatile compounds such as ... [more ▼]

Deacidification in physical refining is one of the most sensitive steps in refining edible vegetable oils because of its large impact on the quality of the oil. The removal of volatile compounds such as FFA is accomplished at elevated temperatures and a high vacuum with a stripping gas, usually steam. The aim of this work was to verify, at the laboratory level, the advantages of using an alternative stripping gas, nitrogen, instead of steam. An ideal vapor-liquid equilibrium model (lVLE) was used to compare the stripping capacities of steam and nitrogen and to analyze the effects of various operational parameters (temperature, pressure, amount of stripping gas) on the residual acidity of the oil. There was no clear evidence that nitrogen showed a higher capacity to strip FFA than steam. The IVLE model seemed suitable to describe FFA laboratory distillation by using steam or nitrogen, provided the final residual content of FFA was not too low. [less ▲]

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See detailDysfonctionnements cognitifs dans la schizophrénie: des résultats de la recherche aux prises en charges cliniques
Blairy, Sylvie ULg; Philippot, P; Steegen, G et al

in Revue Francophone de Clinique Comportementale et Cognitive (2004), 9(2), 9-19

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See detailMUNE in the last 30 years: what can we expect of it in practice?
WANG, François-Charles ULg; GERARD, Pascale ULg; BOUQUIAUX, Olivier ULg

in Correspondances en Nerf & Muscle (2004)

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See detailAUDIT MINERALOGIQUE AU NOUVEAU CONCENTRATEUR DE KIPUSHI
Bastin, David ULg; Krier, William

Report (2004)

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See detailMeasure Noun constructions: degrees of delexicalization and grammaticalization
Brems, Lieselotte ULg

in Advances in corpus linguistics: Papers from the 23rd International Conference on English Language Research on Computerized Corpora (ICAME 23). (2004)

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See detailA trust region algorithm for automatic identification of elasto-viscoplastic model parameters in metallurgical finite element model
Jeunechamps, Pierre-Paul ULg; Walmag, Jérôme; Duysinx, Pierre ULg et al

in Steel Grips 2 (2004), Supplement Metal Forming 2004

Simulation of manufacturing processes, here metal forming, has made major progresses during the last years. The virtual simulation of the manufacturing process being now quite well established, a natural ... [more ▼]

Simulation of manufacturing processes, here metal forming, has made major progresses during the last years. The virtual simulation of the manufacturing process being now quite well established, a natural step ahead consists in trying to find automatic procedures to optimize it. Another perspective is also to take care of the influence of the manufacturing constraints upon the design, which is the long term objective of the present research project. It aims at optimizing the design subject to both service constraints (stiffness and strength) and manufacturing constraints. A preliminary stage is to be able to build high fidelity digital models. Complex models require more and more material parameters for behavior laws (e.g. material constitutive and friction laws), which have to be identified numerically from experimental data. In this material parameter identification process, three steps can be identified. At first, an experimental testing is carried out. The second step consists in building a simulation model of the experiment. Finally, the unknown model parameters are determined to match the experimental data. A standard identification procedure consists in minimizing a given norm (here the Euclidean norm) of the error between the model predictions and the experimental results. Even if the identification problem is generally quasi-unconstrained, it has the same complexity as structural optimization problems because of the highly nonlinear and implicit character of the functions, which is especially amplified by the large deformation simulation analysis. In this paper, we use an approach of elastoplastic calculation by finite elements combined with two optimization algorithms: a Levenberg-Marquardt algorithm, which is rather classical in the literature for solving identification problems (see [2]) and a trust-region one (see [1]), which is a rather novel approach at least for structural problems. The results obtained with these two methods are then compared and discussed on two test cases. The first application is an academic test case to validate the identification method. The second one, the compression of a cylinder, takes into account an actual experiment. In this application, the material is assumed to be elasto-viscoplastic and described by a Norton-Hoff behavior law and an isotropic strain hardening law. The parameters to be identified are the coefficients of the Norton-Hoff law. [less ▲]

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See detailLandscape pattern analysis using independent pattern components and landscape transformation processes.
Bogaert, Jan ULg

in The 19th Annual Symposium of the IALE US regional association. (2004)

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See detailLa forêt privée wallonne et sa gestion : des chiffres qui parlent
Colson, Vincent ULg; Puissant, T.; Hebert, Jacques ULg et al

Book (2004)

An investigation relative to Walloon private forest owners was carried out in order to characterise their properties and the management undergone in each one of them, as well as to identify the main ... [more ▼]

An investigation relative to Walloon private forest owners was carried out in order to characterise their properties and the management undergone in each one of them, as well as to identify the main problems the owners encounter. The results of this study emphasise on the existence of multiple aspects of owners and of their properties. The majority of the Walloon private properties represent above all an important inheritance along with a strong sentimental attachment in regards to the owner. A high proportion of owners manage their forest themselves by devoting a lot of time, but without necessarily planning management. This study clearly shows that a large number of owners wish to be more informed and guided. [less ▲]

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See detailHigh incidence of complications after 2-chloro-2'-deoxyadenosine combined with cyclophosphamide in patients with advanced lymphoproliferative malignancies.
Van Den Neste, E.; Michaux, L.; LAYIOS, Nathalie ULg et al

in Annals of Hematology (2004), 83(6), 356-63

The combination of purine analogs with alkylating agents is able to produce a synergistic antitumoral effect. However, the addition of immunosuppressive and DNA-targeting agents might increase purine ... [more ▼]

The combination of purine analogs with alkylating agents is able to produce a synergistic antitumoral effect. However, the addition of immunosuppressive and DNA-targeting agents might increase purine analog-related complications. The risk for serious complications was evaluated in 38 patients treated with 2-chloro-2'-deoxyadenosine (CDA) and cyclophosphamide (CP). The diagnoses were chronic lymphocytic leukemia (CLL) in 15, Waldenstrom's macroglobulinemia in 4, mantle cell lymphoma in 6, follicular non-Hodgkin's lymphoma (NHL) in 10, and other low-grade NHL in 3 patients. All patients were pretreated (median: 2 lines, range: 1-5) and 23 (61%) were refractory. The patients received a median of two courses (range: 1-5) of 5.6 mg/m(2) CDA, followed by a median of 200 mg/m(2) CP, for 3 days. The response rate was 51% [complete remission (CR): 14%, partial remission (PR): 38%]. Grade 3/4 infections occurred in 16 (42%) patients. Dose-limiting cytopenias were seen in 22 (58%) patients. In 12 (32%) patients, autoimmune manifestations developed requiring treatment in most of them. Second cancers arose in five (13%) patients (myelodysplastic syndrome/acute myelocytic leukemia in three, lung cancer in two). Multivariate analysis showed that cytopenias, gender (F), prior radiotherapy, and age (>65 years) predicted for the complications seen after CDA-CP. To conclude, because of the high incidence of complications, caution is warranted in selecting patients with advanced lymphoid malignancies for the CDA-CP protocol. [less ▲]

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