References of "2004"
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See detailRebabelizar el mundo. Por una ética de la reciprocidad
Brisset, Annie; Willson, Patricia ULg

Article for general public (2004)

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See detailLa brique cuite
Berthelet, Yann ULg

E-print/Working paper (2004)

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See detailL'excès pondéral et l'obésité chez l'enfant
Guillaume, Michèle ULg; Burniat, W

in ONE (Ed.) Prévention et petite enfance : guide de médecine préventive du nourrisson et du jeune enfant (2004)

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See detailCyclodextrins as a potential carrier in drug nebulization.
Evrard, Brigitte ULg; Bertholet, P.; Guéders, Maud ULg et al

in Journal of Controlled Release (2004), 96(3), 403-10

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the ... [more ▼]

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the feasibility of using different cyclodextrins (CDs) to elaborate pharmaceutical formulations for the inhalation route and tested the short-term toxicity of such formulations administered by inhalation to C57BL/6 mice. We have shown that HP-beta-CD, gamma-CD, as well as RAMEB aqueous solutions can undergo aerosolization and that the resulting droplet-size ranges are compatible with pulmonary deposition. In vivo, we have demonstrated that short-term exposure to inhaled HP-beta-CD, gamma-CD and RAMEB solutions are non-toxic after assessing bronchoalveolar lavage (BAL), lung and kidney histology, bronchial responsiveness to methacholine and blood urea. The only change noted is a slight increase in lymphocyte count in the BAL after HP-beta-CD and gamma-CD inhalation. We conclude that CDs are useful in significantly enhancing the solubility of apolar drugs with a view to inhalation therapy although an increase in lymphocyte counts in the BAL after CDs inhalations needs further investigations. [less ▲]

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See detailCushing's disease : very long-term results of transsphenoidal, clinical and genetic studies
Stevenaert, Achille ULg; Perrin, G.; Martin, Didier ULg et al

in 12th International Congress of Endocrinology - Abstract book (2004)

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See detailEpidemiology and outcome of acute lung injury in European intensive care units. Results from the ALIVE study
Brun-Buisson, Christian; Minelli, Cosetta; Bertolini, Guido et al

in Intensive Care Medicine (2004), 30(1), 51-61

Abstract Objectives: To re-examine the epidemiology of acute lung injury (ALI) in European intensive care units (ICUs). Design and setting: A 2-month inception cohort study in 78 ICUs of 10 European ... [more ▼]

Abstract Objectives: To re-examine the epidemiology of acute lung injury (ALI) in European intensive care units (ICUs). Design and setting: A 2-month inception cohort study in 78 ICUs of 10 European countries. Patients: All patients admitted for more than 4 h were screened for ALI and followed up to 2 months. Measurements and main results: Acute lung injury occurred in 463 (7.1%) of 6,522 admissions and 16.1% of all mechanically ventilated patients; 65.4% cases occurred on ICU admission. Among 136 patients initially presenting with “mild ALI” (200< PaO2/FiO2 £300), 74 (55%) evolved to acute respiratory distress syndrome (ARDS) within 3 days. Sixty-two patients (13.4%) remained with mild ALI and 401 had ARDS. The crude ICU and hospital mortalities were 22.6% and 32.7% (p<0.001), and 49.4% and 57.9% (p=0.0005), respectively, for mild ALI and ARDS. ARDS patients initially received a mean tidal volume of 8.3±1.9 ml/kg and a mean PEEP of 7.7±3.6 cmH2O; air leaks occurred in 15.9%. After multivariate analysis, mortality was associated with age (odds ratio (OR) =1.2 per 10 years; 95% confidence interval (CI): 1.05–1.36), immuno-incompetence (OR: 2.88; Cl: 1.57–5.28), the severity scores SAPS II (OR: 1.16 per 10% expected mortality; Cl: 1.02–1.31) and logistic organ dysfunction (OR: 1.25 per point; Cl: 1.13–1.37), a pH less than 7.30 (OR: 1.88; Cl: 1.11–3.18) and early air leak (OR: 3.16; Cl: 1.59–6.28). Conclusions: Acute lung injury was frequent in our sample of European ICUs (7.1%); one third of patients presented with mild ALI, but more than half rapidly evolved to ARDS. While the mortality of ARDS remains high, that of mild ALI is twice as low, confirming the grading of severity between the two forms of the syndrome. [less ▲]

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See detailAcanthosis nigricans associated with insulin resistance : pathophysiology and management.
Hermanns-Lê, Trinh ULg; Scheen, André ULg; Pierard, Gérald ULg

in American Journal of Clinical Dermatology (2004), 5(3), 199-203

The association of acanthosis nigricans, skin tags, diabetes mellitus due to insulin resistance, and obesity in adolescents and young adults represents a well defined syndrome. Hyperandrogenism may also ... [more ▼]

The association of acanthosis nigricans, skin tags, diabetes mellitus due to insulin resistance, and obesity in adolescents and young adults represents a well defined syndrome. Hyperandrogenism may also be present. The endocrine origin of this condition is beyond doubt. Insulin and insulin-like growth factor-1, and their receptors on keratinocytes are obviously involved in the complex regulations leading to the peculiar epidermal hyperplasia. This condition is unrelated to other types of acanthosis nigricans, including the congenital and the paraneoplastic types.Control of obesity contributes largely to reverse the whole process, essentially by reducing both insulin resistance and compensatory hyperinsulinemia. Several drugs including metformin, octreotide, retinoids and topical colecalciferol (vitamin D(3)) analogs are also beneficial in clearing acanthosis nigricans. [less ▲]

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See detailEntrée dans la vie adulte et processus d'affiliation identitaire
Guillaume, Jean-François ULg

in Istace, Evelyne; Laffut, Michel; Plasman, Robert (Eds.) et al Sphères privée et professionnelle : vers une recomposition des rôles et des actions (2004)

Dans quelle mesure jeunes hommes et jeunes femmes intègrent-ils les injonctions sociales poussant à la réussite, à l'autonomie, à l'épanouissement personnel,... au moment de poser des choix familiaux et ... [more ▼]

Dans quelle mesure jeunes hommes et jeunes femmes intègrent-ils les injonctions sociales poussant à la réussite, à l'autonomie, à l'épanouissement personnel,... au moment de poser des choix familiaux et professionnels ? Dans quelle mesure le groupe des pairs offre-t-il des repères pour les identités en construction ? [less ▲]

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See detailAnisotropic scaling in YBa2Cu3O7 crystals with columnar defects
Silhanek, Alejandro ULg; Civale, L.

in Journal of Low Temperature Physics (2004), 135(1-2), 157-160

We explore the interplay between the mass anisotropy and the uniaxial pinning of tilted columnar defects (CD) in a YBa2Cu3O7 single crystal. At high temperatures T and fields H a sharp peak in the ... [more ▼]

We explore the interplay between the mass anisotropy and the uniaxial pinning of tilted columnar defects (CD) in a YBa2Cu3O7 single crystal. At high temperatures T and fields H a sharp peak in the irreversible magnetization M-i at the direction of the tracks signals the presence of the CD. At low T such a peak is not observed, and the influence of the CD appears only as a perturbation to the angular dependence due to the anisotropy. We show that at low T and high H the uniaxial effects due to CD can be recovered by performing an anisotropic rescaling. As expected, this scaling fails at low H. [less ▲]

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See detailBiodiversiteit
Hambuckers, Alain ULg

in Marbaix, P.; van Ypersele, J.-P. (Eds.) Impacts van de klimaatveranderingen in België (2004)

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See detailChicago - Le Vatican du Gospel (pt 4)
Sacré, Robert ULg

Article for general public (2004)

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See detailTreatment of osteoporosis with biphosphonates - Do compliance and persistence matter ?
Reginster, Jean-Yves ULg; LECART, Marie-Paule ULg

in Business briefing : Long-term Healthcare (2004), 5

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See detailApproaching the true prevalence of pituitary tumors
Beckers, Albert ULg; Ciccarelli, A.; Daly, Adrian ULg et al

in 12th International Congress of Endocrinology - Abstract book (2004)

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See detailLe medicament du mois. Rosuvastatine (Crestor).
Scheen, André ULg

in Revue Médicale de Liège (2004), 59(1), 56-9

Rosuvastatin (Crestor) has been recently launched in Belgium by AstraZeneca. This new statin is indicated for the treatment of primary hypercholesterolaemia or combined dyslipidaemia, when changes in ... [more ▼]

Rosuvastatin (Crestor) has been recently launched in Belgium by AstraZeneca. This new statin is indicated for the treatment of primary hypercholesterolaemia or combined dyslipidaemia, when changes in dietary habits are insufficient. Direct comparative randomised clinical trials with other statins demonstrated that rosuvastatin exerts a more favourable impact on lipid profile. When compared on a mg basis to other statins, rosuvastatin is associated with a greater reduction in total and LDL cholesterol levels and a greater increase of HDL cholesterol concentration, with a similar decrease in triglyceride levels. At the usual dosage of 10 mg, rosuvastatin allowed to reduce LDL cholesterol below recommended target levels for at risk patients among almost 80% of treated individuals in phase III clinical trials. If necessary, the daily dosage may be increased to 20 mg, or up to 40 mg (maximal dose), mostly in case of severe familial hypercholesterolaemia. Safety profile is good and similar to that of other commercialised statins. Rosuvastatin is currently evaluated in an extensive programme of randomised clinical trials (Galaxy programme) in order to demonstrate its efficacy in both prevention of atherosclerosis and reduction of cardiovascular morbidity and mortality. [less ▲]

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See detailElaboration d’une typologie hydro-géomorphologique de cours d’eau dans l’Euregio Meuse-Rhin
Hallot, Eric ULg; Schmitt, L.; Mols, J. et al

in Mosella - XXIX, 3-4 (2004)

This paper shows the first results of a method of river hydro-geomorphological typology applied on the Euregio Maas-Rhine. This is based on non factorial multivariate analysis (clusters) of only ... [more ▼]

This paper shows the first results of a method of river hydro-geomorphological typology applied on the Euregio Maas-Rhine. This is based on non factorial multivariate analysis (clusters) of only quantitative data automatically extracted from DEM or obtained by field measurements with a simplified protocol. The regional differentiation of variables allows the automatic characterization of rivers especially with the specific stream power. [less ▲]

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See detailL’occupation gravettienne de l’Atelier de Taille de la Berge Nord-Est
Miller, Rebecca ULg; Guillaume, Alain; Flas, Damien ULg

in Miller, Rebecca; Haesaerts, Paul; Otte, Marcel (Eds.) L’atelier de taille aurignacien de Maisières-Canal (Belgique) (2004)

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See detailAn energy-momentum conserving algorithm for non-linear hypoelastic constitutive models
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg

in International Journal for Numerical Methods in Engineering (2004), 59(1), 83-114

This paper presents an extension of the energy momentum conserving algorithm, usually developed for hyperelastic constitutive models, to the hypoelastic constitutive models. For such a material no ... [more ▼]

This paper presents an extension of the energy momentum conserving algorithm, usually developed for hyperelastic constitutive models, to the hypoelastic constitutive models. For such a material no potential can be defined, and thus the conservation of the energy is ensured only if the elastic work of the deformation can be restored by the scheme. We propose a new expression of internal forces at the element level which is shown to verify this property. We also demonstrate that the work of plastic deformation is positive and consistent with the material model. Finally several numerical applications are presented. Copyright (C) 2003 John Wiley Sons, Ltd. [less ▲]

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See detailF.E. modelling of electro-mechanical and thermo-elastic couplings in micro-system
Lejeune, Jean-Michel; Lepage, Séverine; Rochus, Véronique ULg et al

Scientific conference (2004)

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