References of "2004"
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See detailOrthophonie, le tremplin du passe, le dynamisme du present, l'essor du futur.
Estienne, Francoise; Morsomme, Dominique ULg

in Presse Médicale (2004), 33 Spec No

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See detailCatalogue des post-incunables conservés à la Bibliothèque royale de Belgique
Adam, Renaud ULg

E-print/Working paper (2004)

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See detailLes trésors de la postérité ou les fastes des proches parents du Prophète (Kitāb Ḏaḫā’ir al-‘uqbā fī manāqib ḏawī al-qurbā)
Muḥibb al-dīn al-Ṭabarī, Aḥmad ibn ‘Abdallāh ibn Muḥammad al-Makkī; Bauden, Frédéric ULg

Book published by Institut français d'archéologie orientale (2004)

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See detailE.T.A. Hoffmann: Das Majorat. Rezension
Küpper, Achim ULg

E-print/Working paper (2004)

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See detailChapter 3, The Integument : Morphology and Biochemistry
Compère, Philippe ULg; Jeuniaux, Charles; Goffinet, Gerhard ULg

in Forest, J.; von Vaupel Klein, J. C.; Schram, F. R. (Eds.) The Crustacea revised and updated from the Traité de Zoologie Vol 1 (2004)

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See detailApplication of different mathematical models for the prediction of bone regeneration in an in vivo bone chamber
Van Oosterwyck, Hans; Geris, Liesbet ULg; Gerisch, A. et al

in Lecture notes of workshop Numerical models of bone adaptation and repair (2004)

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See detailAperçu de la loi du 2 août 2002 concernant la lutte contre le retard de paiement dans les transactions commerciales
Decharneux, Joëlle ULg

in Actualité législative en droit immobilier (2001-2003) (2004)

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See detailAUDIT MINERALOGIQUE AU NOUVEAU CONCENTRATEUR DE KIPUSHI
Bastin, David ULg; Krier, William

Report (2004)

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See detailA two-stage stochastic programming framework for transportation planning in disaster response
Barbarosoglu, Gulay; Arda, Yasemin ULg

in Journal of the Operational Research Society (2004), 55

This study proposes a two-stage stochastic programming model to plan the transportation of vital first-aid commodities to disaster-affected areas during emergency response. A multi-commodity, multi-modal ... [more ▼]

This study proposes a two-stage stochastic programming model to plan the transportation of vital first-aid commodities to disaster-affected areas during emergency response. A multi-commodity, multi-modal network flow formulation is developed to describe the flow of material over an urban transportation network. Since it is difficult to predict the timing and magnitude of any disaster and its impact on the urban system, resource mobilization is treated in a random manner, and the resource requirements are represented as random variables. Furthermore, uncertainty arising from the vulnerability of the transportation system leads to random-arc capacities and supply amounts. Randomness is represented by a finite sample of scenarios for capacity, supply and demand triplet. The two stages are defined with respect to information asymmetry, which discloses uncertainty during the progress of the response. The approach is validated by quantifying the expected value of perfect and stochastic information in problem instances generated out of actual data. [less ▲]

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See detailInterspecific hybridization with Phaseolus vulgaris L.: embryo development and its genetics.
Baudoin, Jean-Pierre ULg; Silue, S.; Geerts, P. et al

in Recent Research Developments in Genetics & Breeding. Vol. 1, Part II (2004)

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See detailPreparation and in vivo toxicity study of solid lipid microparticles as carrier for pulmonary administration
Sanna, V.; Kirschvink, Nathalie; Gustin, Pascal ULg et al

in AAPS PharmScitech (2004), 5(2), 27

The purpose of this research was to investigate the effects of processing conditions on the characteristics of solid lipid microparticles (SLM) with a potential application as carriers for pulmonary ... [more ▼]

The purpose of this research was to investigate the effects of processing conditions on the characteristics of solid lipid microparticles (SLM) with a potential application as carriers for pulmonary administration. Compritol ( 5.0% wt/ wt) SLM dispersions were prepared by rotor-stator homogenization, at different surfactant concentrations and emulsification times. The SLM were characterized, in terms of morphology and size, after lyophilization and sterilization by autoclaving process. In vivo assessment was carried out in rats by intratracheal instillation of either placebo or SLM dispersion, and by bronchoalveolar lavage for cytological analysis. Mean particle size of 4 to 5 mum was achieved using 0.3% and 0.4% ( wt/ wt) of emulsifier ( Poloxamer 188) and emulsification times of 2 and 5 minutes. The particles showed spherical shape and smooth surface. The morphology of microparticles, the size, and the size distribution were not substantially modified after lyophilization and sterilization. Total cell counts showed no significant differences between placebo and SLM 0.5% or 2.5% groups. Regarding cytology, percentage of polymorphonuclear neutrophils and macrophages did not significantly differ between groups. These results suggest that a single intratracheal administration of the SLMs does not induce a significant inflammatory airway response in rats and that the SLMs might be a potential carrier for encapsulated drug via the pulmonary route. [less ▲]

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See detailGraft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning
Baron, Frédéric ULg; Maris, Michael; Sandmaier, Brenda et al

in Blood (2004), 104

We have used a nonmyeloablative conditioning regimen consisting of 2 Gy total body irradiation +/– fludarabine, 30 mg/m²/day x 3 days, to condition elderly or ill patients (pts) with hematological ... [more ▼]

We have used a nonmyeloablative conditioning regimen consisting of 2 Gy total body irradiation +/– fludarabine, 30 mg/m²/day x 3 days, to condition elderly or ill patients (pts) with hematological malignancies for allogeneic hematopoietic cell transplantation (HCT). This approach relies almost exclusively on graft-versus-tumor (GVT) effects for control of malignancy. Here, we analyzed GVT effects in 322 pts with hematological malignancies given grafts from HLA-matched related (n=192) or unrelated (n=130) donors. Grades I, II, III and IV acute GVHD were seen in 26 (8.1%), 141 (43.8%), 34 (10.6%) and 11 (3.4%) pts, respectively. Extensive chronic GVHD was seen in 181 (56.2%) pts and of these, 64 (19.9%) cases had de novo chronic GVHD. Putative GVT effects were evaluated using time-dependent Cox regression models. Of the 221 pts with measurable disease at HCT, 126 (57%) achieved complete (n=98) or partial (n=28) remissions. Multivariate analysis identified chemosensitivity for B-cell malignancies (p=.02), and tandem autologous/allogeneic HCT (p=.04) as pre-transplant factors associated with higher probabilities of achieving complete remissions (CR) after HCT. After adjusting for these factors, acute GVHD of any grade was not found to be associated with an increased probability of achieving CR. There was a trend for a higher probability of achieving CR in pts with chronic GVHD (p=.07). Progression/relapse was observed in 108 pts. Multivariate analysis identified that lower disease-risk (p=.0004), tandem autologous/allogeneic HCT (p=.02) and adapted Charlson comorbidity index (CCI) score at transplant < 3 (p=.002) resulted in significantly decreased risk of progression/relapse. After correcting for these factors, extensive chronic GVHD was associated with a decreased risk of progression/relapse (p=.006). Pts with grade 1 acute GVHD tended to have less progression/relapse (p=.07). Conversely, grade II–IV acute GVHD did not significantly affect the risk of progression/relapse. Nonrelapse mortality was observed in 70 pts. Multivariate analysis showed that lower disease-risk (p=. 001), tandem autologous/allogeneic HCT (p=.002) and CCI score at transplant < 3 (p<.0001) significantly decreased nonrelapse mortality. After adjusting for these variables, grade II (p=.04) and grade III–IV (p<.0001) acute GVHD increased nonrelapse mortality while extensive chronic GVHD did not. The 3-year probability of progression-free survival (PFS) was 38.5%. In multivariate analysis, lower disease-risk (p<.0001), tandem autologous/allogeneic HCT (p=.0008) and CCI score at transplant < 3 (p<.0001) resulted in significantly better PFS. After adjusting for theses variables, grade 1 acute GVHD (p=.02) and chronic extensive GVHD (p=.003) were both associated with significantly better PFS, while grade III–IV acute GVHD (p<.0001) was associated with decreased PFS. In summary, chronic GVHD in pts given nonmyeloablative conditioning was associated with substantial GVT effects which led to improved PFS. Conversely, any potential GVT benefits from grade II–IV acute GVHD were offset by higher nonrelapse mortality resulting in worse PFS. Efforts should be directed at reducing the risk of grade II–IV acute GVHD while allowing de novo chronic GVHD for best PFS after allogeneic HCT with nonmyeloablative conditioning. [less ▲]

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See detailMicrowear and Residue Analysis in Perspective: the contribution of ethnoarchaeological evidence
Rots, Veerle ULg; Williamson, Bonny

in Journal of Archaeological Science (2004), 31

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See detailIntroduction : European Cities and their New Residents
Martiniello, Marco ULg; Penninx, Rinus; Kraal, Karen et al

in Martiniello, Marco; Penninx, Rinus; Kraal, Karen (Eds.) et al Citizenship in European Cities. Immigrants, Local Politics and Integration Policies (2004)

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See detailL'immigration marocaine en Belgique : du travailleur immigré au citoyen transnational
Martiniello, Marco ULg; Bousetta, Hassan ULg

in Khader, Bichara; Roosens, Claude (Eds.) Belges et Arabes : voisins distants, partenaires nécessaires (2004)

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See detailA Set of Equity Indicators of the European Education Systems A synthesis
Demeuse, Marc; Baye, Ariane ULg; Straeten, Marie-Hélène et al

in Moreno Herrera, L.; Francia, G. (Eds.) Educational Policies. Implications for Equity, Equality and Equivalence (2004)

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See detailBistability analyses of a caspase activation model for receptor-induced apoptosis
Eissing, Thomas; Conzelmann, Holger; Gilles, Ernst Dieter et al

in Journal of Biological Chemistry (2004), 279(35), 36892-36897

Apoptosis is an important physiological process crucially involved in development and homeostasis of multicellular organisms. Although the major signaling pathways have been unraveled, a detailed ... [more ▼]

Apoptosis is an important physiological process crucially involved in development and homeostasis of multicellular organisms. Although the major signaling pathways have been unraveled, a detailed mechanistic understanding of the complex underlying network remains elusive. We have translated here the current knowledge of the molecular mechanisms of the death-receptor-activated caspase cascade into a mathematical model. A reduction down to the apoptotic core machinery enables the application of analytical mathematical methods to evaluate the system behavior within a wide range of parameters. Using parameter values from the literature, the model reveals an unstable status of survival indicating the need for further control. Based on recent publications we tested one additional regulatory mechanism at the level of initiator caspase activation and demonstrated that the resulting system displays desired characteristics such as bistability. In addition, the results from our model studies allowed us to reconcile the fast kinetics of caspase 3 activation observed at the single cell level with the much slower kinetics found at the level of a cell population. [less ▲]

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See detailPathologie, leeftijd en geslacht van de olievogels
Jauniaux, Thierry ULg; Masure, S.

(2004)

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See detailResponders to glucosamine sulfate in knee osteoarthritis
Bruyère, Olivier ULg; Pavelka, K.; Richy, F. et al

in Osteoporosis International (2004), 12(SB), 76

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