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See detailEvaluation of the function of ADAMTS-2, a metalloproteinase containing a disintegrin domain and thrombospondin type I repeats, during angiogenesis in vitro and in vivo
Kesteloot, Frédéric ULg; Lapière, Charles M; Colige, Alain ULg et al

in Acta Clinica Belgica (2004), 59(2), 120

Angiogenesis is required for development, growth, tissue remodeling, and wound healing. Pathologies such as diabetic retinopathy, rheumatoid arthritis and cancer would benefit from therapies controlling ... [more ▼]

Angiogenesis is required for development, growth, tissue remodeling, and wound healing. Pathologies such as diabetic retinopathy, rheumatoid arthritis and cancer would benefit from therapies controlling and reducing angiogenesis. Enzymes of the ADAMTS family are closely related to MMPs and ADAMs. They contain however some specific features, such as a variable number of domains known as “ThromboSpondin type I repeat” (TSPI). ADAMTS-1 and -8 are 20-fold more anti-angiogenic than angiostatin and endostatin, two potent inhibitors of angiogenesis. The primary function of ADAMTS-2 is the maturation of collagen type I and II molecules by excising the amino-propeptide. In addition, ADAMTS-2 could also modulate angiogenesis, as it contains the same sequences than those responsible for the anti-angiogenic activity of ADAMTS-1 and -8. This hypothesis was investigated in vitro in different experimental models such as cell proliferation and formation of capillary structures by human endothelial cells. An ex vivo angiogenesis model was also used. It consists in mice or rat aorta pieces embedded in a collagen gel in order to allow the growth of capillaries from the vascular endothelium. As compared to control mice (TS2+/+), angiogenesis was slightly increased, in absence of ADAMTS-2, from aortas of ADAMTS-2 KO mice (TS2-/-). Using rat aortas, addition of recombinant ADAMTS-2 reduced the formation of capillary structure, also confirming the anti-angiogenic activity of ADAMTS-2. Finally, an in vivo model of angiogenesis was also used. Biocompatible sponges (Ivalon) were implanted under the skin of TS2+/+ or TS2-/- mice in order to evaluate the formation of capillaries in the granulation tissue invading the sponge. In absence of ADAMTS-2, angiogenesis and granulation tissue formation were both reduced. Additional investigations are being performed in order to identify the underlying mechanism(s) inducing these modifications. [less ▲]

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See detailA three-month course of depot octreotide in the treatment of Graves' orbitopathy : clinical results of a randomized placebo-controlled double-blind study
Wémeau, J. L.; Beckers, Albert ULg; Caron, P. et al

in 12th International Congress of Endocrinology - Abstract book (2004)

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See detailRemoval of C-terminal Src kinase from the immune synapse by a new binding protein
Mustelin, Tomas; Rahmouni, Souad ULg; Alonso, Andres et al

in Cancer Research (2004), 45

The Csk tyrosine kinase negatively regulates the Src family kinases Lck and Fyn in T cells. Engagement of the T cell antigen receptor results in a removal of Csk from the lipid raft-associated ... [more ▼]

The Csk tyrosine kinase negatively regulates the Src family kinases Lck and Fyn in T cells. Engagement of the T cell antigen receptor results in a removal of Csk from the lipid raft-associated transmembrane protein PAG/Cbp. Instead, Csk becomes associated with a ∼72-kDa tyrosine phosphorylated protein, which we here identify as G3BP, a phosphoprotein reported to bind the SH3 domain of Ras GTPase activating protein. G3BP reduced the ability of Csk to phosphorylate Lck at Y505 by decreasing the amount of Csk in lipid rafts. As a consequence, G3BP augmented T cell activation as measured by IL-2 gene activation. Conversely, elimination of endogenous G3BP by RNA interference reduced TCR signaling. In antigen-specific T cells, endogenous G3BP moved into a intracellular location adjacent to the immune synapse, but well inside the cell, upon antigen recognition. Csk co-localization with G3BP occurred in this ‘parasynaptic’ location. We conclude that G3BP is a new player in TCR signaling that acts to reduce the amount of Csk in the immune synapse. [less ▲]

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See detailMinimising perceived latency in audio-conferencing systems over application-level multicast
Blundell, N.; Mathy, Laurent ULg

in Proceedings of MIPS Workshop (2004)

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See detailL'euthanasie en Belgique et aux Pays-Bas
Leleu, Yves-Henri ULg; Genicot, Gilles ULg

in Revue Trimestrielle des Droits de l'Homme (2004)

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See detailEarly neurophysiological diagnosis of true neurogenic « thoracic outlet syndrome » (TOS)
Hua, MT; DUBUISSON, Annie ULg; Zeevaert, Bernard et al

Poster (2004)

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See detailExclusion et sciences humaines
Jamin, Jérôme ULg

Report (2004)

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See detailLiquid-liquid phase separation in gravity settler with inclined plates
Schlieper, L; Chatterjee, M; Pfennig, Andreas ULg

in AIChE Journal (2004), 50(4), 802-811

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See detailThe White House Corp. Quand les industriels U.S. jouaient aux faucons…
Geuens, Geoffrey ULg

in Collectif (Ed.) Mourir pour McDo en Irak. Colonisation américaine, résistance irakienne (2004)

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See detailSimenon et la “crise” du roman
Denis, Benoît ULg

in Traces. Travaux du Centre d'Études Georges Simenon (2004), (15), 95-106

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See detailAz energiaegyensúly zavarának hatása a méh involúciójára és a ciklikus petefészek működésére tejhasznú tehenekben]
Könyves, L.; Brydl, E.; Jurkovich, V. et al

in Proceedings: 5th Middle-European Buiatrics Congress (2004)

The aim of the study was to evaluate the effect of energy imbalance (manifested increased blood NEFA) on reactivation of the ovaries, uterine involution and the incidence of retained placenta and ... [more ▼]

The aim of the study was to evaluate the effect of energy imbalance (manifested increased blood NEFA) on reactivation of the ovaries, uterine involution and the incidence of retained placenta and endometritis [less ▲]

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See detailMiospores and the emergence of land plants
Steemans, Philippe ULg; Wellman, C. H.

in Webby, B.; Paris, F.; Droser, M.L. (Eds.) et al The Great Ordovician Biodiversification Event (2004)

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See detailUne langue entre soi
Servais, Christine ULg

in Exils : théorie, histoire, figures, pratiques (2004)

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See detailEarly neurophysiological diagnosis of true neurogenic « thoracic outlet syndrome » (TOS)
HUA, MT; DUBUISSON, Annie ULg; Zeevaert, Bernard et al

in Journal of Neurology (2004)

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See detailActualité du permis d'environnement, du permis unique et un mot du CWATUP
Pâques, Michel ULg

in Actualité législative en droit immobilier (2004)

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See detailMeasurement of selected halogenated contaminants in human serum and milk using GCxGC-IDTOFMS
Focant, Jean-François ULg; sjodin, Andreas; Turner, Wayman et al

in Organohalogen Compounds (2004)

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