References of "2004"
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See detailStudy of a novel elicitor produced by Pseudomonas putida BTP1 in the ISR on bean
Jourdan, Emmanuel ULg; Ongena, Marc ULg; Schaffer, M. et al

Poster (2004, December 17)

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See detailHistoricité de la condition rurale en République populaire de Chine
Florence, Eric ULg

Scientific conference (2004, December 17)

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See detailReduced-order modeling and control of lightweight parallel manipulators: Theory and experiments
Bruls, Olivier ULg

Scientific conference (2004, December 16)

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See detailHypogonadism in a Patient with a Mutation in the Luteinizing Hormone Beta-Subunit Gene
Valdes Socin, Hernan Gonzalo ULg; Salvi, R.; Daly, Adrian ULg et al

in New England Journal of Medicine [=NEJM] (2004), 351(25), 2619-2625

A 30-year-old man who presented with delayed puberty and infertility was found to have hypogonadism associated with an absence of circulating luteinizing hormone. The patient had a homozygous missense ... [more ▼]

A 30-year-old man who presented with delayed puberty and infertility was found to have hypogonadism associated with an absence of circulating luteinizing hormone. The patient had a homozygous missense mutation in the gene that encodes the beta subunit of luteinizing hormone (Gly36Asp), a mutation that disrupted a vital cystine knot motif and abrogated the heterodimerization and secretion of luteinizing hormone. Treatment with human chorionic gonadotropin increased circulating testosterone, promoted virilization, and was associated with the appearance of normal spermatozoa in low concentrations. This case illustrates the important physiological role that luteinizing hormone plays in male sexual maturation and fertility. [less ▲]

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See detailMETHOD FOR MONITORING COLLAGEN TYPE II DEGRADATION IN CARTILAGE
Reginster, Jean-Yves ULg; Deberg, Michelle; Henrotin, Yves ULg et al

Patent (2004)

A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in most ... [more ▼]

A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in most mammals ultizes an immunoassay to detect fragments of collagen type II resulting from collagenase activity comprising an antibody directed against an epitope comprised in the amino acid sequence HRGYPGLDG, located in the helical region of collagen type II. [less ▲]

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See detailPreparation and characterization of xerogel catalyst microspheres
Alié, Christelle ULg; Ferauche, Fabrice; Heinrichs, Benoît ULg et al

in Journal of Non-Crystalline Solids (2004), 350

For easier handling and use in fixed bed reactors, Pd-Ag/SiO2 aerogel-like xerogel catalysts were shaped into microspheres using the microencapsulation process developed by BRACE GmbH. Before the bead ... [more ▼]

For easier handling and use in fixed bed reactors, Pd-Ag/SiO2 aerogel-like xerogel catalysts were shaped into microspheres using the microencapsulation process developed by BRACE GmbH. Before the bead production process, the xerogel catalyst was ground in water and mixed with ethylene glycol and sodium alginate, the latter of which is the gelation agent. The beads were formed at a vibrating nozzle and solidified during their fall in a water tank containing calcium ions, which induce cross-linking of the alginate and consequent bead hardening. Preliminary work was done using a syringe instead of the material-consuming BRACE unit. The beads were made from a suspension of dried only, dried and calcined, or dried, calcined, and reduced catalyst. The textural properties of the beads were analyzed by nitrogen adsorption-desorption isotherms and mercury porosimetry; and bead catalytic activity was tested for selective hydrodechlorination of 1,2-dichloroethane. The beads made from a suspension of dried catalyst appear to have properties the closest to that of the xerogel reference catalyst. Porosity and surface area are maintained at their level before bead formation. However conversion of 1,2-dichloroethane decreases after the production process, possibly due to poisoning by calcium ions. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailZoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibition
Chaplet, Michaël; Deroanne, Christophe ULg; Fisher, Larry W. et al

in Biochemical Journal (2004), 384(Pt 3), 591-598

Clinical practice reveals that osteoporotic women treated with BPs (bisphosphonates) show an increased bone mass density and a reduced risk of fractures. However, the mechanisms leading to these ... [more ▼]

Clinical practice reveals that osteoporotic women treated with BPs (bisphosphonates) show an increased bone mass density and a reduced risk of fractures. However, the mechanisms leading to these beneficial effects of BPs are still poorly understood. We hypothesized that ZOL (zoledronic acid), a potent third-generation BP, may induce the expression of proteins associated with the bone-forming potential of osteoblastic cells such as BSP (bone sialoprotein). Expression of BSP gene is up-regulated by hormones that promote bone formation and has been associated with de novo bone mineralization. Using real-time reverse transcriptase-PCR and Western-blot analysis, we demonstrated that ZOL increased BSP expression in Saos-2 osteoblast-like cells. Nuclear run-on and mRNA decay assays showed no effect at the transcriptional level but a stabilization of BSP transcripts in ZOL-treated cells. ZOL effect on BSP expression occurred through an interference with the mevalonate pathway since it was reversed by either mevalonate pathway intermediates or a Rho GTPase activator. We showed that ZOL impaired membrane localization of RhoA in Saos-2 cells indicating reduced prenylation of this protein. By the use of small interfering RNAs directed to RhoA and Rac1, we identified both Rho GTPases as negative regulators of BSP expression in Saos-2 cells. Our study demonstrates that ZOL induces BSP expression in osteoblast-like cells through inactivation of Rho GTPases and provides a potential mechanism to explain the favourable effects of ZOL treatment on bone mass and integrity. [less ▲]

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See detailBubble and granular flows: differences and similarities
Caps, Hervé ULg; Trabelsi, Samy ULg; Dorbolo, Stéphane ULg et al

in Physica A: Statistical Mechanics and its Applications (2004), 344(3-4), 424-430

We have experimentally studied the dense flow of identical bubbles below planes inclined at an angle theta. The flow is driven by the fast motion of dislocations. As a function of the density of ... [more ▼]

We have experimentally studied the dense flow of identical bubbles below planes inclined at an angle theta. The flow is driven by the fast motion of dislocations. As a function of the density of dislocations (controlled by the parameter theta), a transition occurs between a simple collective block motion and a granular-like surface flow regime. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailCurrent levels of drug resistance among therapy-naive HIV-infected patients have significant impact on treatment response
Derdelinckx, Inge; Van Laethem, Kristel; Maes, Bart et al

in Journal of Acquired Immune Deficiency Syndromes [=JAIDS] (2004), 37(5), 1664-1666

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See detailMise en évidence de la faille de Marenne sur la carte géologique Aye - Marche-en-Famenne
Coen-Aubert, Marie; Barchy, Laurent ULg; Marion, Jean-Marc ULg et al

in Bulletin de l'Institut royal des Sciences naturelles de Belgique, Sciences de la Terre (2004), 74(supplement), 59-7118

The revision of the geological map Aye - Marche-en-Famenne (Belgium, Wallonia, Hotton) has emphasized an important deformation structure named the Marenne Fault. This fault is clearly visible at the ... [more ▼]

The revision of the geological map Aye - Marche-en-Famenne (Belgium, Wallonia, Hotton) has emphasized an important deformation structure named the Marenne Fault. This fault is clearly visible at the southeastern face of the Marenne quarry. The dating by rugose corals has allowed to define with precision the Givetian lithologic units that have been put in contact by this normal faul with a later, right-lateral strike-slip component. This fault, that may be traced over a few kilometers to the East, is probably late Hercynian, of the same type and origin as the Lamsoul Fault know to the South of Marche-en-Famenne. It seems to form part of a family of faults which are regularly observed on the south side of the Dinant Synclinorium. [less ▲]

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See detailCyclo-oxygenase type 2-dependent prostaglandin E-2 secretion is involved in retrovirus-induced T-cell dysfunction in mice
Rahmouni, Souad ULg; Aandahl, Einar Martin; Nayjib, Btissam ULg et al

in Biochemical Journal (2004), 384(Pt 3), 469-476

MAIDS (murine AIDS) is caused by infection with the murine leukaemia retrovirus RadLV-Rs and is characterized by a severe immunodeficiency and T-cell anergy combined with a lymphoproliferative disease ... [more ▼]

MAIDS (murine AIDS) is caused by infection with the murine leukaemia retrovirus RadLV-Rs and is characterized by a severe immunodeficiency and T-cell anergy combined with a lymphoproliferative disease affecting both B- and T-cells. Hyperactivation of the cAMP-protein kinase A pathway is involved in the T-cell dysfunction of MAIDS and HIV by inhibiting T-cell activation through the T-cell receptor. In the present study, we show that MAIDS involves a strong and selective up-regulation of cyclo-oxygenase type 2 in the CD11b+ subpopulation of T- and B-cells of the lymph nodes, leading to increased levels of PGE2 (prostaglandin E2). PGE2 activates the cAMP pathway through G-protein-coupled receptors. Treatment with cyclo-oxygenase type 2 inhibitors reduces the level of PGE2 and thereby reverses the T-cell anergy, restores the T-cell immune function and ameliorates the lymphoproliferative disease. [less ▲]

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See detailL'utilisation des antipsychotiques atypiques en pédopsychiatrie, et particulièrement dans l'enfance
Scholl, Jean-Marc ULg

Conference given outside the academic context (2004)

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See detailSaturn's UV Aurora Imaged with HST during the Cassini Approach to Saturn
Clarke, J. T.; Gérard, Jean-Claude ULg; Grodent, Denis ULg et al

Poster (2004, December 13)

A series of HST STIS UV images of Saturn's aurora were obtained on 13 days in Jan. 2004 as the Cassini spacecraft measured the approaching solar wind properties. Clear general correlations have been found ... [more ▼]

A series of HST STIS UV images of Saturn's aurora were obtained on 13 days in Jan. 2004 as the Cassini spacecraft measured the approaching solar wind properties. Clear general correlations have been found between the auroral power and a) Saturn's kilometric radiation, and b) the solar wind dynamic pressure, but not with the direction of the interplanetary magnetic field. While these general correlations are now well established, a closer examination of the data raises many interesting questions. Saturn's auroral emissions exhibit both local time and co-rotational properties, the auroral oval does not appear centered on the magnetic and rotational pole, the auroral emissions exhibit large and unexpected motions in latitude with time and/or planetary rotation, and the auroral oval does not appear continuous, but broken with longitude. This talk will present a more detailed look at Saturn's aurora from the HST images, with a comparison of auroral emission properties to those at the Earth and Jupiter. [less ▲]

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See detailLa fin de la Belgique ou la fin du modèle régionaliste
Hermans, Michel ULg

Conference (2004, December 13)

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See detailLa maladie d'Alzheimer
Adam, Stéphane ULg

Conference given outside the academic context (2004)

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See detailPrepartum management of severe preeclampsia
Brichant, Jean-François ULg

Conference (2004, December 11)

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See detailEts-dependent regulation of target gene expression during megakaryopoiesis
Jackers, Pascale ULg; Szalai, Gabor; Moussa, Omar et al

in Journal of Biological Chemistry (2004), 279(50), 52183-52190

Megakaryopoiesis is the process by which hematopoietic stem cells in the bone marrow differentiate into mature megakaryocytes. The expression of megakaryocytic genes during megakaryopoiesis is controlled ... [more ▼]

Megakaryopoiesis is the process by which hematopoietic stem cells in the bone marrow differentiate into mature megakaryocytes. The expression of megakaryocytic genes during megakaryopoiesis is controlled by specific transcription factors. Fli-1 and GATA-1 transcription factors are required for development of megakaryocytes and promoter analysis has defined in vitro functional binding sites for these factors in several megakaryocytic genes, including GPIIb, GPIX, and C-MPL. Herein, we utilize chromatin immunoprecipitation to examine the presence of Ets-1, Fli-1, and GATA-1 on these promoters in vivo. Fli-1 and Ets-1 occupy the promoters of GPIIb, GPIX, and C-MPL genes in both Meg-01 and CMK11-5 cells. Whereas GPIIb is expressed in both Meg-01 and CMK11-5 cells, GPIX and C-MPL are only expressed in the more differentiated CMK11-5 cells. Thus, in vivo occupancy by an Ets factor is not sufficient to promote transcription of some megakaryocytic genes. GATA-1 and Fli-1 are both expressed in CMK11-5 cells and co-occupy the GPIX and C-MPL promoters. Transcription of all three megakaryocytic genes is correlated with the presence of acetylated histone H3 and phosphorylated RNA polymerase II on their promoters. We also show that exogenous expression of GATA-1 in Meg-01 cells leads to the expression of endogenous c-mpl and gpIX mRNA. Whereas GPIIb, GPIX, and C-MPL are direct target genes for Fli-1, both Fli-1 and GATA-1 are required for formation of an active transcriptional complex on the C-MPL and GPIX promoters in vivo. In contrast, GPIIb expression appears to be independent of GATA-1 in Meg-01 cells. [less ▲]

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