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See detailAnálisis cladístico de la correlación entre patogenia y marcadores moleculares en la región 5’ LTR del Virus de la Leucosis Bovina
Rodriguez, Sabrina ULg; Zwerdling, A.; Jones, L.R. et al

Poster (2004, November 14)

ANALISIS CLADISTICO DE LA CORRELACION ENTRE PATOGENIA Y MARCADORES MOLECULARES EN LA REGION 5’ LTR DEL VIRUS DE LA LEUCOSIS BOVINA. SM Rodriguez1; A Zwerdling1; LR Jones1; K Trono1 1Instituto de Virología ... [more ▼]

ANALISIS CLADISTICO DE LA CORRELACION ENTRE PATOGENIA Y MARCADORES MOLECULARES EN LA REGION 5’ LTR DEL VIRUS DE LA LEUCOSIS BOVINA. SM Rodriguez1; A Zwerdling1; LR Jones1; K Trono1 1Instituto de Virología, CICVyA, INTA-Castelar. CC 25 (1712), Castelar, Argentina. El virus de la leucosis bovina (Bovine Leukemia Virus, BLV) es un miembro de la familia Retroviridae. Esta familia incluye los virus responsables de la leucemia de células T de los humanos (Human T-Cell Lymphotropic Virus-1 y -2) y de los simios (Simian T-lymhotropic Virus). BLV afecta al ganado bovino produciendo en un reducido numero de animales (2-5%) una neoplasia linfoproliferativa de células B de origen clonal conocida como Leucosis Bovina Enzootica (LBE). La mayoría de los individuos infectados con BLV son portadores asintomáticos (AL), cursando la infección sin signos clínicos aparentes. Alrededor del 30% de los animales infectados desarrolla una proliferación benigna policlonal de células B, denominada Linfocitosis Persistente (LP). En nuestro laboratorio hemos secuenciado la zona R-U5 del sector 5' LTR de aislamientos provenientes de 36 animales presentando diferentes formas clínicas. El resultado de estos estudios reveló la presencia de 4 bases covariantes para provirus aislados de linfosarcoma (LS). Estas modificaciones están ausentes en la mayoría (16/22) de los provirus aislados de formas asintomáticas (AL/PL). Si bien esta aparente correlación entre los cambios de nucleótidos y los cuadros clínicos sugiere la presencia de marcadores de patogenia, es necesario analizar dentro de un contexto histórico (cladograma) la aparición independiente de dicho marcador en conjunto con el desarrollo de LS. Para ello, se obtuvieron las secuencias correspondientes a la región genómica codificante env y pX para algunos de estos aislamientos de LS y AL/PL. Las secuencias fueron alineadas mediante el programa ClustalX y los alineamientos fueron utilizados para obtener cladogramas mediante las rutinas de máxima parsimonia del programa PAUP*. El análisis de los árboles obtenidos sugiere que la adquisición del marcador en la región LTR y el desarrollo de LS en diferentes aislamientos serían independientes, apoyando la hipótesis de la existencia de un marcador de patogenia en dicha zona regulatoria. [less ▲]

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See detailPolitiques sportives pour la "non violence"
Comeron, Manuel ULg

Conference (2004, November 14)

ÁREAS TEMÁTICAS: 1. MEDIOS DE COMUNICACIÓN (Radiotelevisión y Prensa), ASOCIACIONISMO DEPORTIVO Y CLUBES DE LIGAS FEDERADAS. 2. ACADÉMICA Y EDUCATIVA (EL DEPORTE, LA VIOLENCIA Y LOS PROCESOS DE ... [more ▼]

ÁREAS TEMÁTICAS: 1. MEDIOS DE COMUNICACIÓN (Radiotelevisión y Prensa), ASOCIACIONISMO DEPORTIVO Y CLUBES DE LIGAS FEDERADAS. 2. ACADÉMICA Y EDUCATIVA (EL DEPORTE, LA VIOLENCIA Y LOS PROCESOS DE CIVILIZACIÓN : Antropología del Deporte, Psicología eEolutiva de la Actividad Física y Sociología y del Deporte) 3. LEGISLATIVA (LEGISLACIÓN EN EL ÁMBITO DE LA VIOLENCIA DEPORTIVA) 4. LAS POLÍTICAS DEPORTIVAS PARA LA “NOVIOLENCIA” (VIOLENCIA DESDE EL PUNTO DE VISTA DEL ENTORNO / MODELO INTERNACIONAL, NACIONAL Y AUTONÓMICO) [less ▲]

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See detailLe pilotage du système éducatif via des indicateurs
Baye, Ariane ULg

Conference given outside the academic context (2004)

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See detailFully automated method for the liquid chromatographic-tandem mass spectrometric determination of cyproterone acetate in human plasma using restricted access material for on-line sample clean-up
Christiaens, B.; Fillet, Marianne ULg; Chiap, Patrice ULg et al

in Journal of Chromatography. A (2004), 1056(1-2), 105-110

A new automated method for the quantitative analysis of cyproterone acetate (CPA) in human plasma has been developed using on-line solid phase extraction (SPE) prior to the LC-MS/MS determination. The ... [more ▼]

A new automated method for the quantitative analysis of cyproterone acetate (CPA) in human plasma has been developed using on-line solid phase extraction (SPE) prior to the LC-MS/MS determination. The method was based on the use of a pre-column packed with internal-surface reversed-phase material (LiChrospher RP-4 ADS, 25 mm x 2 mm) for sample clean-up coupled to LC separation on an octadecyl silica stationary phase by means of a column switching system. A 30 microl plasma sample volume was injected directly onto the pre-column using a mixture of water, acetonitrile and formic acid (90:10:0.1 (v/v/v)) adjusted to pH 4.0 with diluted ammonia as washing liquid. The analyte was then eluted in the back-flush mode with the LC mobile phase consisting of water, methanol and formic acid (10:90:0.1 (v/v/v)). The dispensing flow rates of the washing liquid and the LC mobile phase were 300 microl min(-1). Medroxyprogesterone acetate (MPA) was used as internal standard. The MS ionization of the analytes was achieved using electrospray (ESI) in the positive ion mode. The pseudomolecular ionic species of CPA and MPA (417.4 and 387.5) were selected to generate daughter ions at 357.4 and 327.5, respectively. Finally, the developed method was validated according to a new approach using accuracy profiles as a decision tool. Very good results with respect to accuracy, detectability, repeatability, intermediate precision and selectivity were obtained. The LOQ of cyproterone acetate was 300 pg ml(-1). [less ▲]

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See detailGestion globale du traitement de l'hypertension artérielle
Krzesinski, Jean-Marie ULg

Conference (2004, November 12)

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See detailEfficient algorithmic approach for mixed-lubrication in cold rolling
Stephany, A.; Ponthot, Jean-Philippe ULg; Collette, C. et al

in Journal of Materials Processing Technology (2004), 153(1), 307-313

A model of cold rolling taking into account lubrication in mixed mode was developed. The main objective is to obtain a numerical tool that permits us to optimise a mill configuration from the lubrication ... [more ▼]

A model of cold rolling taking into account lubrication in mixed mode was developed. The main objective is to obtain a numerical tool that permits us to optimise a mill configuration from the lubrication point of view. It means that lubricant viscosity but also roll diameter and roughness, rolling diagrams, etc could be modified to improve stability and efficiency of the mill. A modified slab method is solved iteratively and is coupled with a sophisticated tribological model. A general calculation of the modified Reynolds equation is presented in order to evaluate the fluid pressure for any piezoviscosity law. The coupling is made through the calculation of fluid thickness and friction along the roll bite. The evolution of the cylinder/strip contact area due to the asperity crushing along the roll bite is also considered. A parametric study has been undertaken in order to determine the influence of various process parameters on friction and lubricant flow. Applications to industrial cases obtained from Cockerill Sambre plant will show the applicability of the method. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailNumerical simulation of springback using enhanced assumed strain elements
Bui, Q. V.; Papeleux, Luc ULg; Ponthot, Jean-Philippe ULg

in Journal of Materials Processing Technology (2004), 153(1), 314-318

The quality of springback prediction for a sheet metal forming process depends on a precise estimate of the elasto-plastic stress distribution throughout the metal sheet. The use of low-order conventional ... [more ▼]

The quality of springback prediction for a sheet metal forming process depends on a precise estimate of the elasto-plastic stress distribution throughout the metal sheet. The use of low-order conventional finite elements may be, without any proper treatment, responsible for low quality prediction because of volumetric and shear lockings. In this study, the enhanced assumed strain technique will be exploited for locking removal. The quality of the numerical simulation is evaluated through a comparison with other popular techniques like selective and uniform reduced integration. In contrast to the latter, and thanks to a full numerical integration scheme, the enhanced assumed strain element is very efficient in accurately capturing the development of plastic flow. This enables a reliable prediction of springback even with a rather coarse mesh. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailParticle size analysis : a multidimensional approach
Grandfils, Christian ULg

Conference (2004, November 09)

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See detailEquity indicators in the field of continuous education and training
Baye, Ariane ULg

Scientific conference (2004, November 08)

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See detailLe syndrome de Parsonage et Turner
Kaux, Jean-François ULg; Wang, François ULg

Conference (2004, November 02)

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See detailStructural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin
Bourges, I.; Ramus, C.; de Camaret, B. M. et al

in Biochemical Journal (2004), 383(Part 3), 491-499

Mitochondria-encoded ND (NADH dehydrogenase) subunits, as components of the hydrophobic part of complex I, are essential for NADH:ubiquinone oxidoreductase activity. Mutations or lack of expression of ... [more ▼]

Mitochondria-encoded ND (NADH dehydrogenase) subunits, as components of the hydrophobic part of complex I, are essential for NADH:ubiquinone oxidoreductase activity. Mutations or lack of expression of these subunits have significant pathogenic consequences in humans. However, the way these events affect complex I assembly is poorly documented. To understand the effects of particular mutations in ND subunits on complex I assembly, we studied four human cell lines: ND4 non-expressing cells, ND5 non-expressing cells, and rhodegrees cells that do not express any ND subunits, in comparison with normal complex I control cells. In control cells. all the seven analysed nuclear-encoded complex I subunits Were found to be attached to the mitochondrial inner membrane, except for the 24 kDa subunit, which was nearly equally partitioned between the membranes and the matrix. Absence of a single ND subunit, or even all the seven ND subunits, caused no major changes in the nuclear-encoded complex I subunit content of mitochondria. However, in cells lacking ND4 or ND5, very low amounts of 24 kDa subunit were found associated with the membranes, whereas most of the other nuclear-encoded subunits remained attached. In contrast, membrane association of most of the nuclear subunits was significantly reduced in the absence of all seven ND proteins. Immunopurification detected several subcomplexes. One of these, containing the 23, 30 and 49 kDa subunits, also contained prohibitin. This is the first description of prohibitin interaction with complex I subunits and suggests that this protein might play a role in the assembly or degradation of mitochondrial complex I. [less ▲]

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See detailOptical polarization of 203 QSOs (Sluse+, 2005)
Sluse, D.; Hutsemekers, Damien ULg; Lamy, H. et al

Textual, factual or bibliographical database (2004)

This Table contains linear polarization measurements (mainly in the V band) of 203 QSOs. First time measurements have been obtained for 184 objects. Among them 109 known radio emitters, 42 BAL and 1 ... [more ▼]

This Table contains linear polarization measurements (mainly in the V band) of 203 QSOs. First time measurements have been obtained for 184 objects. Among them 109 known radio emitters, 42 BAL and 1 gravitationally lensed QSO. (1 data file). [less ▲]

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See detailMeasurement of selected polybrominated diphenyl ethers, polybrominated and polychlorinated biphenyls, and organochlorine pesticides in human serum and milk using comprehensive two-dimensional gas chromatography isotope dilution time-of-flight mass spectrometry
Focant, Jean-François ULg; Sjodin, Andreas; Turner, Wayman E. et al

in Analytical Chemistry (2004), 76(21), 6313-6320

A new method using comprehensive two-dimensional gas chromatography and isotope dilution time-of-flight mass spectrometry (GC x GC-IDTOFMS) for the simultaneous measurement of selected polychlorinated ... [more ▼]

A new method using comprehensive two-dimensional gas chromatography and isotope dilution time-of-flight mass spectrometry (GC x GC-IDTOFMS) for the simultaneous measurement of selected polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), and brominated flame retardants is presented. In contrast to the reference methods based on classical GC/MS, a single injection of the extract containing all compounds of interest results in accurate identification and quantification. Using GC x GC ensures the chromatographic separation of most compounds, and TOFMS allows mass spectral deconvolution of coeluting compounds as well as the use of C-13-labeled internal standards for quantification. Isotope ratio measurements of the most intense ions for both native and labels ensure the required specificity. The use of this new method with an automated sample preparation procedure developed at the Centers for Disease Control and Prevention (CDC) for the analysis of human serum and milk compared favorably to conventional isotope-dilution one-dimensional gas chromatography-high-resolution mass spectrometty (GC-IDHRMS) for the different human serum and milk pools tested. The instrumental detection limits ranged between 0.5 pg/muL and 10 pg/muL and the method detection limits ranged between I and 15 pg/muL (N = 59 analytes). The reproducibility of the method was almost as good as with GC-IDHRMS, the relative standard deviations ranging between 1 and 11% for OCPs measured in human serum. OCP, PBDE, and PCB levels measured using the two methods were highly correlated, and the deviations between the two methods were below 20% for most analytes with concentrations above 1 ng/g milk lipids. [less ▲]

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See detailComet C/2001 Q4 (NEAT) at its closest approach to the Earth
Tozzi, G. P.; Boehnhardt, H.; Del Bo, M. et al

in American Astronomical Society, DPS meeting #36 (2004, November 01)

Comet C/2001 Q4 (NEAT) was observed at ESO (La Silla) for three consecutive nights at the beginning of May, 2004 at its closest approach to Earth. The observations consisted of quasi-simultaneous multi ... [more ▼]

Comet C/2001 Q4 (NEAT) was observed at ESO (La Silla) for three consecutive nights at the beginning of May, 2004 at its closest approach to Earth. The observations consisted of quasi-simultaneous multi-wavelength exposures in the visible, near-IR and thermal-IR in order to study different properties of the solid component that are responsible for the scattering and emission of radiation in different spectral ranges. The comet was observed with the 3.6m telescope, equipped with TIMMI2 for the thermal-IR region, the NTT, equipped with EMMI and SOFI for the visible and near-IR regions. Narrow band images and long slit spectra were recorded for each spectral region. In the near-IR range, polarimetric observations were also performed during the last night. The aim of the observations was the characterization of the solid component at small scalelength to search for possible short lifetime organic components, as those found in the comet C/2000 WM1 (Tozzi et al., 2004, A&A, 424, 235), dust fragmentation etc.. Here we report preliminary results of the analysis of these observations. [less ▲]

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See detailPolarization properties of broad absorption line QSOs: New statistical clues
Lamy, H.; Hutsemekers, Damien ULg

in Astronomy and Astrophysics (2004), 427

We report the results of several statistical tests performed on a large sample of 139 broad absorption line (BAL) QSOs with good quality optical spectra and/or optical polarization data. Correlations ... [more ▼]

We report the results of several statistical tests performed on a large sample of 139 broad absorption line (BAL) QSOs with good quality optical spectra and/or optical polarization data. Correlations between ten optical indices and the polarization degree p[SUB]0[/SUB] are systematically searched for. We find six significant non-trivial correlations. In order to identify the most important correlations, we perform a principal component analysis with a sample of 30 BAL QSOs and eight quantities (including p[SUB]0[/SUB]). Most of the variance (Ë 57%) in the data is contained in two principal components called PC1 and PC2. PC1 is mainly dominated by the correlation between the balnicity index BI and the strength of the Fe II emission; it may be driven by the accretion rate of matter onto the central compact object. The variance in PC2 is essentially due to the anti-correlation between p[SUB]0[/SUB] and the detachment index DI, indicating that BAL QSOs with P Cygni profiles (DIâ ª) are usually more polarized than those objects with C IV absorption troughs well detached from the corresponding emission lines (DIâ «). We show that PC2 may be related to the orientation of the BAL QSOs with respect to the line of sight. We also present new spectropolarimetric observations of six BAL QSOs. By adding spectropolarimetric data from the literature, we build a sample of 21 BAL QSOs for which we define four spectropolarimetric indices describing the polarization properties of the absorption and emission lines. We find that the polarization of the C III]] emission line is systematically higher than the polarization of the C IV emission line, and that the highest polarization in the troughs is correlated to the balnicity index. Another important result emerging from the statistical tests performed on this spectropolarimetric sample is a possible anti-correlation between the detachment index and a quantity SI which measures the ratio of the depths of the C IV absorption in the polarized flux and in the total flux. This correlation indicates that in BAL QSOs with P cygni profiles, the BAL troughs in the polarized flux are nearly as deep as in the total flux while, in BAL QSOs with detached absorptions, the BAL troughs in the polarized flux are much weaker than in the total flux. We show that our main results may be explained in the framework of a ``two-component'' wind model which is a natural extension of the classical wind-from-disk models. In this model, the broad absorption occurs in a dense equatorial wind emerging from the accretion disk, while scattering and polarization mainly take place in a polar region. The orientation relative to the observer drives the correlations p[SUB]0[/SUB] - DI and DI - SI. While most of our observations can be explained within this framework, there are also several indications that other polarization mechanisms, and more particularly resonance scattering, may also be at work. Based on observations collected at the European Southern Observatory (ESO, La Silla). Table 1 is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http: / / cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/427/107 [less ▲]

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See detailThe photospheric abundances of active binaries. III. Abundance peculiarities at high activity levels
Morel, Thierry ULg; Micela, G.; Favata, F. et al

in Astronomy and Astrophysics (2004), 426

We report the determination from high-resolution spectra of the atmospheric parameters and abundances of 13 chemical species (among which lithium) in 8 single-lined active binaries. These data are ... [more ▼]

We report the determination from high-resolution spectra of the atmospheric parameters and abundances of 13 chemical species (among which lithium) in 8 single-lined active binaries. These data are combined with our previous results for 6 other RS CVn systems to examine a possible relationship between the photospheric abundance patterns and the stellar activity level. The stars analyzed are generally found to exhibit peculiar abundance ratios compared to inactive, Galactic disk stars of similar metallicities. We argue that this behaviour is unlikely to be an artefact of errors in the determination of the atmospheric parameters or non-standard mixing processes along the red giant branch, but diagnoses instead the combined action of various physical processes related to activity. The most promising candidates are cool spot groups covering a very substantial fraction of the stellar photosphere or NLTE effects arising from nonthermal excitation. However, we cannot exclude the possibility that more general shortcomings in our understanding of K-type stars (e.g. inadequacies in the atmospheric models) also play a significant role. Lastly, we call attention to the unreliability of the (V-R) and (V-I) colour indices as temperature indicators in chromospherically active stars. Based on observations collected at the European Southern Observatory, Chile (Proposals 64.L-0249 and 071.D-0260). Table A.1 is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/426/1007 [less ▲]

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