References of "2004"
     in
Bookmark and Share    
See detailFiches barrages mobiles : vanne gonflante, claper et Obermeyer, Rapport final, Projet barrages mobiles
Rigo, Philippe ULiege; Lizin, Sandra; Herbillon, Vincent

Report (2004)

Detailed reference viewed: 133 (7 ULiège)
See detailLes batardeaux de maintenance, Rapport final, Projet barrages mobiles
Rigo, Philippe ULiege; Lizin, Sandra; Herbillon, vincent

Report (2004)

Detailed reference viewed: 43 (2 ULiège)
See detailCalcul des strcutures à double fond (suite)-Rapport R&D8
Rigo, Philippe ULiege

Report (2004)

Detailed reference viewed: 29 (0 ULiège)
See detailTechnique de préfabrication et standardisation, Rapport final, Projet barrages mobiles
Rigo, Philippe ULiege; Lizin, Sandra; Herbillon, Vincent

Report (2004)

Detailed reference viewed: 63 (3 ULiège)
Full Text
See detailDe Koninklijke Bibliotheek van België koopt uitzonderlijke incunabel aan
Adam, Renaud ULiege

Article for general public (2004)

Detailed reference viewed: 27 (0 ULiège)
Full Text
Peer Reviewed
See detailCombination/Sequential Therapy in Osteoporosis
Lecart, Marie-Paule; Bruyère, Olivier ULiege; Reginster, Jean-Yves ULiege

in Current Osteoporosis Reports (2004), 2(4), 123-30

Combination therapy includes the concomitant or sequential use of compounds sharing the same mode of action (eg, two or more inhibitors of bone resorption) or with distinct pathways of activity (eg, an ... [more ▼]

Combination therapy includes the concomitant or sequential use of compounds sharing the same mode of action (eg, two or more inhibitors of bone resorption) or with distinct pathways of activity (eg, an inhibitor of resorption plus an anabolic agent). Combination use of antiresorptive agents may generate concerns, because of the risk of inducing oversuppression of bone turnover. However, if low doses of estrogen, used for the management of climacteric symptoms, are insufficient to normalize bone turnover, the addition of a bisphosphonate to hormone therapy may prove to be useful to achieve this objective. Patients pretreated with inhibitors of resorption, who have not achieved a full therapeutic response, are good candidates for treatment with anabolic agents. The increase in bone turnover that comes after the introduction of parathyroid hormone (PTH) in patients treated with an antiresorptive agent is similar to that observed in treatment-naive patients and the pattern of bone mineral density (BMD) increase is also identical, with the exception of a 6 month delay in the spine and hip BMD changes observed in prior alendronate-treated subjects. Current data discourage the concomitant use of alendronate and PTH since the bisphosphonate appears to blunt (in men and women) the anabolic action of PTH. Whether this applies to other bisphosphonates or inhibitors of resorption, remains unknown. The use of an inhibitor of bone resorption after completion of PTH treatment seems an appropriate way to maintain the skeletal benefits gained during therapy. Long-term clinical studies, using fractures as an endpoint should be initiated to better understand the clinical and pharmaco-economic interest of combination therapies in the management of osteoporosis. [less ▲]

Detailed reference viewed: 33 (2 ULiège)
Full Text
Peer Reviewed
See detailThe Inflammatory Hypothesis of Ageing: Fascinating Concept or Confusing Dogma?
Pierard, Gérald ULiege; Pierard-Franchimont, Claudine ULiege

in Journal of Cosmetic Dermatology (2004), 3(4), 246

Detailed reference viewed: 10 (0 ULiège)
See detailOn the way of understanding the adaptation to extreme pH of family 11 xylanases: Structural comparison and mutational analysis
De Lemos Esteves, Frédéric ULiege; Ruelle, Virginie; Gouders, Thierry et al

Poster (2004, December)

Detailed reference viewed: 15 (2 ULiège)
Full Text
Peer Reviewed
See detailFunctional analysis of the cell division protein FtsW of Escherichia coli
Pastoret, Soumya; Fraipont, Claudine ULiege; den Blaauwen, Tanneke et al

in Journal of Bacteriology (2004), 186(24), 8370-8379

Site-directed mutagenesis experiments combined with fluorescence microscopy shed light on the role of Escherichia coli FtsW, a membrane protein belonging to the SEDS family that is involved in ... [more ▼]

Site-directed mutagenesis experiments combined with fluorescence microscopy shed light on the role of Escherichia coli FtsW, a membrane protein belonging to the SEDS family that is involved in peptidoglycan assembly during cell elongation, division, and sporulation. This essential cell division protein has 10 transmembrane segments (TMSs). It is a late recruit to the division site and is required for subsequent recruitment of penicillin-binding protein 3 (PBP3) catalyzing peptide cross-linking. The results allow identification of several domains of the protein with distinct functions. The localization of PBP3 to the septum was found to be dependent on the periplasmic loop located between TMSs 9 and 10. The E240-A249 amphiphilic peptide in the periplasmic loop between TMSs 7 and 8 appears to be a key element in the functioning of FtsW in the septal peptidoglycan assembly machineries. The intracellular loop (containing the R166-FI78 amphiphilic peptide) between TMSs 4 and 5 and Gly 311 in TMS 8 are important components of the amino acid sequence-folding information. [less ▲]

Detailed reference viewed: 130 (14 ULiège)
Full Text
Peer Reviewed
See detailDevelopment of a universal microarray based on the ligation detection reaction and 16S rRNA gene polymorphism to target diversity of cyanobacteria
Castiglioni, Bianca; Rizzi, Ermann; Frosini, Andrea et al

in Applied and Environmental Microbiology (2004), 70(12), 7161-7172

The cyanobacteria are photosynthetic prokaryotes of significant ecological and biotechnological interest, since they strongly contribute to primary production and are a rich source of bioactive compounds ... [more ▼]

The cyanobacteria are photosynthetic prokaryotes of significant ecological and biotechnological interest, since they strongly contribute to primary production and are a rich source of bioactive compounds. In eutrophic fresh and brackish waters, their mass occurrences (water blooms) are often toxic and constitute a high potential risk for human health. Therefore, rapid and reliable identification of cyanobacterial species in complex environmental samples is important. Here we describe the development and validation of a microarray for the identification of cyanobacteria in aquatic environments. Our approach is based on the use of a ligation detection reaction coupled to a universal array. Probes were designed for detecting 19 cyanobacterial groups including Anabaena/Aphanizomenon, Calothrix, Cylindrospermopsis, Cylindrospermum, Gloeothece, halotolerants, Leptolyngbya, Palau Lyngbya, Microcystis, Nodularia, Nostoc, Planktothrix, Antarctic Phormidium, Prochlorococcus, Spirulina, Synechococcus, Synechocystis, Trichodesmium, and Woronichinia. These groups were identified based on an alignment of over 300 cyanobacterial 16S rRNA sequences. For validation of the microarrays, 95 samples (24 axenic strains from culture collections, 27 isolated strains, and 44 cloned fragments recovered from environmental samples) were tested. The results demonstrated a high discriminative power and sensitivity to 1 fmol of the PCR-amplified 16S rRNA gene. Accurate identification of target strains was also achieved with unbalanced mixes of PCR amplicons from different cyanobacteria and an environmental sample. Our universal array method shows great potential for rapid and reliable identification of cyanobacteria. It can be easily adapted to future development and could thus be applied both in research and environmental monitoring. [less ▲]

Detailed reference viewed: 52 (10 ULiège)
Full Text
Peer Reviewed
See detailCerebral folate deficiency
Ramaekers, Vincent ULiege; Blau, Nenad

in Developmental medicine and child neurology (2004), 46(12), 843-51

Cerebral folate deficiency (CFD) can be defined as any neurological syndrome associated with low cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF), the active folate metabolite, in the presence ... [more ▼]

Cerebral folate deficiency (CFD) can be defined as any neurological syndrome associated with low cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF), the active folate metabolite, in the presence of normal folate metabolism outside the nervous system. CFD could result from either disturbed folate transport or from increased folate turnover within the central nervous system (CNS). We report on a novel neurometabolic syndrome in 20 children, which we term 'idiopathic CFD'. Typical features became manifest from the age of 4 months, starting with marked unrest, irritability, and sleep disturbances followed by psychomotor retardation, cerebellar ataxia, spastic paraplegia, and dyskinesia; epilepsy developed in about one third of the children. Most children showed deceleration ofhead growth from the age of 4 to 6 months. Visual disturbances began to develop around the age of 3 years and progressive sensorineural hearing loss started from the age of 6 years. Neuroimaging showed atrophy of frontotemporal regions and periventricular demyelination in seven children, slowly progressive supra- and infratentorial atrophy in three children, and normal findings in the remainder. Because active folate transport to the CNS occurs through receptor-mediated folate receptor protein 1 (FR1) endocytosis, DNA sequencing of the FR1 gene was performed and found to be normal. However, CSF protein analysis revealed a non-functional FR1 protein, suspected to result from either post-translational defects of FR1 protein N-glycosylation, the presence of folate antagonists with irreversible binding, or autoantibodies blocking the folate binding site of FR1. Oral treatment with 5-formyltetrahydrofolate (folinic acid) should be started in low doses at 0.5-1mg/kg/day, but in some patients higher daily doses of folinic acid at 2-3 mg/kg/day are required to normalize CSF 5MTHF values. This proposed treatment protocol resulted in a favourable clinical response in patients identified before the age of six years while partial recovery with poorer outcome was found beyond the age of 6 years. Careful clinical and EEG monitoring should be performed 1, 3, and 6 months after the beginning of treatment. After four to six months of folinic acid treatment, CSF analysis should be repeated in order to prevent over- or under-dosage of folinic acid. Secondary forms of CFD have been recognized during chronic use of antifolate and anticonvulsant drugs and in various known conditions such as Rett syndrome, Aicardi-Goutieres syndrome, 3-phosphoglycerate dehydrogenase deficiency, dihydropteridine reductase deficiency, aromatic amino acid decarboxylase deficiency, and Kearns-Sayre syndrome. The pathogenic link between these underlying specific disease entities and the observed secondary CFD has not been resolved. [less ▲]

Detailed reference viewed: 34 (1 ULiège)
Full Text
Peer Reviewed
See detailVirologic therapy response significantly correlates with the number of active drugs as evaluated using a LiPA HIV-1 resistance scoring system
Ziermann, Rainer; Celis, Linda; Derdelinckx, Inge et al

in Journal of Clinical Virology (2004), 31(Suppl. 1), 7-15

Background: Resistance testing is increasingly accepted as a tool in guiding the selection of human immunodeficiency virus type 1 (HIV-1) antiretroviral therapy in HIV-1 infected individuals who fail ... [more ▼]

Background: Resistance testing is increasingly accepted as a tool in guiding the selection of human immunodeficiency virus type 1 (HIV-1) antiretroviral therapy in HIV-1 infected individuals who fail their current regimen. Objectives: To descriptively compare the correlation between virologic treatment response and results using three genotypic HIV-1 drug resistance interpretation systems: the VERSANT(R) HIV-1 Resistance Assay (LiPA) system and two sequence-based interpretation systems. Study design: Specimens from 213 HIV-1-infected subjects, either starting (n = 104) or switching to (n = 109) a regimen of three or four antiretroviral drugs, were collected retrospectively at baseline and after 3 months of uninterrupted therapy. The correlation between viral load change and the number of predicted active drugs in the treatment regimen was assessed. An interpretation algorithm was recently developed to process VERSANT(R) HIV-1 Resistance Assay (LiPA) data. The number of active drugs predicted using this algorithm was rank correlated with the viral load change over a 3-month treatment period. For comparison, a similar calculation was made using two sequence-based algorithms (REGA version 5.5 and VGI GuideLines(TM) Rules 4.0), both applied on the same sequences. Results: Statistically significant (p < 0.05) correlation coefficients for each of the three HIV-1 drug resistance interpretation systems were observed in the treatment-experienced subjects on a 3-drug regimen (-0.39, -0.38, and -0.42, respectively) as well as on a 4-drug regimen (-0.33, -0.31, and -0.37, respectively). However, no significant correlation was observed in treatment-naive subjects, probably due to the very low frequency of drug resistance in these subjects. Conclusion: All three genotypic drug resistance interpretation systems (LiPA version 1, REGA version 5.5, and VGI GuideLines(TM) Rules 4.0) were statistically significantly correlated with virologic therapy response as measured by viral load testing. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 35 (3 ULiège)
Full Text
See detailSeismic Diagrams for beta Cephei stars; A database for COROT
Thoul, Anne ULiege

Conference (2004, December)

Detailed reference viewed: 12 (0 ULiège)
See detailMeasurement of Dioxins and WHO-PCBs in Foodstuffs using GCxGC-IDTOFMS
Focant, Jean-François ULiege; De Pauw, Edwin ULiege

Scientific conference (2004, December)

Detailed reference viewed: 7 (0 ULiège)
Full Text
See detailA Long-Term Slip-Rate Study Along The North Anatolian Fault, Eksik, Turkey Using Cosmogenic 36Cl
Kozaci, O; Dolan, J; Finkel, R et al

in EOS : Transactions, American Geophysical Union (2004, December)

Detailed reference viewed: 9 (0 ULiège)
Full Text
See detailRelationships between incremental and cumulative fold growth with neotectonic examples from the southern Tianshan, China
Suppe, J; Hubert, Aurelia ULiege; Wang, Xin

in EOS : Transactions, American Geophysical Union (2004, December)

Detailed reference viewed: 10 (1 ULiège)
See detailOn the Robustness of Air-Sea Flux Estimates of Carbon Dioxide from Ocean Inversions
Mikaloff Fletcher, S. E.; Gruber, N. P.; Jacobson, A. et al

Conference (2004, December)

Inverse methods analogous to those used for atmospheric inversions have been adapted to estimate regional air-sea fluxes of carbon dioxide using ocean interior observations of dissolved inorganic carbon ... [more ▼]

Inverse methods analogous to those used for atmospheric inversions have been adapted to estimate regional air-sea fluxes of carbon dioxide using ocean interior observations of dissolved inorganic carbon and related tracers and an Ocean General Circulation Model (OGCM). We estimate seperately the preindustrial component and the component due to the anthropogenic perturbation of atmospheric carbon dioxide. Previous sensitivity studies have shown that model circulation is one of the most important sources of error in the ocean inversion. We present estimates of preindustrial and anthropogenic air-sea carbon dioxide exchange using a suite of nine different OGCM's in order to quantify the robustness of our results and explore the role of different representations of ocean circulation in the inversion. Most of the large scale features of the inverse estimates are robust across all models. The preindustrial inverse estimates generally follow the expected pattern of uptake at high latitudes and out gassing in the tropics; however, all of the models call for out gassing in the Southern Ocean between 44S and 58 S. The greatest anthropogenic carbon uptake occurs at mid- to high- latitudes, with a large anthropogenic carbon sink in the Southern Ocean, while the bulk of the anthropogenic carbon storage occurs at mid-latitudes. Preliminary results also suggest interesting, robust differences between these inverse estimates and estimates from forward model simulations. Both the preindustrial and anthropogenic carbon dioxide flux estimates are most robust at mid and high northern latitudes, except for the high latitude North Atlantic. The carbon dioxide flux estimates are most uncertain in the Southern Ocean, where the inverse estimates are strongly dependent on the rates of deep water ventilation in the OGCM. The preindustrial inverse estimates for the Indian Ocean are also sensitive to the choice of OGCM, and the anthropogenic estimates have significant uncertainties in the tropical Pacific. Over large spatial scales, inverse estimates based on different OGCM's are in better agreement than estimates based on forward simulations of the same models, but this is not necessarily true for smaller model regions. [less ▲]

Detailed reference viewed: 10 (0 ULiège)