References of "2004"
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See detailCerebral folate deficiency
Ramaekers, Vincent ULg; Blau, Nenad

in Developmental medicine and child neurology (2004), 46(12), 843-51

Cerebral folate deficiency (CFD) can be defined as any neurological syndrome associated with low cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF), the active folate metabolite, in the presence ... [more ▼]

Cerebral folate deficiency (CFD) can be defined as any neurological syndrome associated with low cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF), the active folate metabolite, in the presence of normal folate metabolism outside the nervous system. CFD could result from either disturbed folate transport or from increased folate turnover within the central nervous system (CNS). We report on a novel neurometabolic syndrome in 20 children, which we term 'idiopathic CFD'. Typical features became manifest from the age of 4 months, starting with marked unrest, irritability, and sleep disturbances followed by psychomotor retardation, cerebellar ataxia, spastic paraplegia, and dyskinesia; epilepsy developed in about one third of the children. Most children showed deceleration ofhead growth from the age of 4 to 6 months. Visual disturbances began to develop around the age of 3 years and progressive sensorineural hearing loss started from the age of 6 years. Neuroimaging showed atrophy of frontotemporal regions and periventricular demyelination in seven children, slowly progressive supra- and infratentorial atrophy in three children, and normal findings in the remainder. Because active folate transport to the CNS occurs through receptor-mediated folate receptor protein 1 (FR1) endocytosis, DNA sequencing of the FR1 gene was performed and found to be normal. However, CSF protein analysis revealed a non-functional FR1 protein, suspected to result from either post-translational defects of FR1 protein N-glycosylation, the presence of folate antagonists with irreversible binding, or autoantibodies blocking the folate binding site of FR1. Oral treatment with 5-formyltetrahydrofolate (folinic acid) should be started in low doses at 0.5-1mg/kg/day, but in some patients higher daily doses of folinic acid at 2-3 mg/kg/day are required to normalize CSF 5MTHF values. This proposed treatment protocol resulted in a favourable clinical response in patients identified before the age of six years while partial recovery with poorer outcome was found beyond the age of 6 years. Careful clinical and EEG monitoring should be performed 1, 3, and 6 months after the beginning of treatment. After four to six months of folinic acid treatment, CSF analysis should be repeated in order to prevent over- or under-dosage of folinic acid. Secondary forms of CFD have been recognized during chronic use of antifolate and anticonvulsant drugs and in various known conditions such as Rett syndrome, Aicardi-Goutieres syndrome, 3-phosphoglycerate dehydrogenase deficiency, dihydropteridine reductase deficiency, aromatic amino acid decarboxylase deficiency, and Kearns-Sayre syndrome. The pathogenic link between these underlying specific disease entities and the observed secondary CFD has not been resolved. [less ▲]

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See detailInformation et échanges autour de la vaccination : une expérience positive
Miermans, Marie-Christine ULg

in Promouvoir la santé à l'école (2004), (8), 3-4

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See detailVirologic therapy response significantly correlates with the number of active drugs as evaluated using a LiPA HIV-1 resistance scoring system
Ziermann, Rainer; Celis, Linda; Derdelinckx, Inge et al

in Journal of Clinical Virology (2004), 31(Suppl. 1), 7-15

Background: Resistance testing is increasingly accepted as a tool in guiding the selection of human immunodeficiency virus type 1 (HIV-1) antiretroviral therapy in HIV-1 infected individuals who fail ... [more ▼]

Background: Resistance testing is increasingly accepted as a tool in guiding the selection of human immunodeficiency virus type 1 (HIV-1) antiretroviral therapy in HIV-1 infected individuals who fail their current regimen. Objectives: To descriptively compare the correlation between virologic treatment response and results using three genotypic HIV-1 drug resistance interpretation systems: the VERSANT(R) HIV-1 Resistance Assay (LiPA) system and two sequence-based interpretation systems. Study design: Specimens from 213 HIV-1-infected subjects, either starting (n = 104) or switching to (n = 109) a regimen of three or four antiretroviral drugs, were collected retrospectively at baseline and after 3 months of uninterrupted therapy. The correlation between viral load change and the number of predicted active drugs in the treatment regimen was assessed. An interpretation algorithm was recently developed to process VERSANT(R) HIV-1 Resistance Assay (LiPA) data. The number of active drugs predicted using this algorithm was rank correlated with the viral load change over a 3-month treatment period. For comparison, a similar calculation was made using two sequence-based algorithms (REGA version 5.5 and VGI GuideLines(TM) Rules 4.0), both applied on the same sequences. Results: Statistically significant (p < 0.05) correlation coefficients for each of the three HIV-1 drug resistance interpretation systems were observed in the treatment-experienced subjects on a 3-drug regimen (-0.39, -0.38, and -0.42, respectively) as well as on a 4-drug regimen (-0.33, -0.31, and -0.37, respectively). However, no significant correlation was observed in treatment-naive subjects, probably due to the very low frequency of drug resistance in these subjects. Conclusion: All three genotypic drug resistance interpretation systems (LiPA version 1, REGA version 5.5, and VGI GuideLines(TM) Rules 4.0) were statistically significantly correlated with virologic therapy response as measured by viral load testing. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailWealth Breeds Decline: Reversals of Leadership and Consumption Habits
Artige, Lionel ULg; Camacho, Carmen; de la Croix, David

in Journal of Economic Growth (2004), 9(4), 423-449

In a two-region model, we formalize Kindlebergerrsquos idea that wealth breeds first more wealth, and then decline: when one region leads, its inhabitants develop consumption habits incompatible with the ... [more ▼]

In a two-region model, we formalize Kindlebergerrsquos idea that wealth breeds first more wealth, and then decline: when one region leads, its inhabitants develop consumption habits incompatible with the necessary investment in knowledge to remain the leader. This gives the other region a window of opportunity to gain economic primacy. The theory suggests that differences across regions that have similar characteristics may persist even if physical capital flows from rich to poor regions. We study patterns of overtaking, alternating primacy, irreversible decline, and monotonic convergence, according to the initial dispersion of knowledge and the strength of consumption habits. Even though exogenous factors may matter on some occasions, we show that they are not necessary to reverse economic leadership. [less ▲]

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See detailSeismic Diagrams for beta Cephei stars; A database for COROT
Thoul, Anne ULg

Conference (2004, December)

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See detailLe Rwanda et ses mille collines pour une meilleure production laitière
Hanzen, Christian ULg

Conference given outside the academic context (2004)

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See detailMeasurement of Dioxins and WHO-PCBs in Foodstuffs using GCxGC-IDTOFMS
Focant, Jean-François ULg; De Pauw, Edwin ULg

Scientific conference (2004, December)

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See detailUn homme, une vocation
Claustriaux, Jean-Jacques ULg; Nuyt, Cécile

in Echosud (2004), 5

Quelles sont les raisons pour lesquelles un universitaire s'intéresse aux pays du Sud ?

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See detailIntérêt des modèles des plus proches voisins pour le contrôle de l'hétérogénéité spatiale : application à un essai de provenances de pin d'Alep (pinus halepensis mill.) en Tunisie
Sghaier, T.; Claustriaux, Jean-Jacques ULg; Beji, A.

in Revue de l'I.N.A.T. (2004), 19(2), 5-22

To study the importance of the spatial analysis in the control of soil heterogeneity in experiment on field, three approaches of statistical analysis were applied to a total height of trees measured at 29 ... [more ▼]

To study the importance of the spatial analysis in the control of soil heterogeneity in experiment on field, three approaches of statistical analysis were applied to a total height of trees measured at 29 years of age in a comparative test of thirty origins of Aleppo pine (Pinus halepensis Mill.), autochtonous and introduced in Tunisia. Analysis without control of heterogeneity (totally random), with a global control of heterogeneity (complete blocks) and with a local control of heterogeneity (nearest neighbour models) were used. For this last approach using to estimate the plot fertility the one of the nearby plots, various combinations of neighbour were tested with one or two coefficients of regression. The obtained results showed that the reduction of the residual mean square by comparison to the analysis without control of heterogeneity is 30 % to the complete blocks analysis and varied between 66 and 79 % for spatial analysis. Significant positive correlations between plots residues and the average of the residues of the nearby plots were observed before adjustment of data. After adjustment of data by the nearest neighbour models, these correlations were registered a reduction from 92 to 95 % according to the used model. Among the six nearest neighbour models studied, the model bringing in eight neighbours with two coefficients of regression showed itself the most effective. It also seemed that after adjustment of data by nearest neighbour models, using the structure of blocks does not produce a reduction of the residual mean square. [less ▲]

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See detailInteractions entre la prothèse fixe et l'endodontie
MAINJOT, Amélie ULg

Scientific conference (2004, December)

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See detailApplication du modèle PEGASE à l'échelle du Bassin Moselle/Sarre dans le contexte de la de la mise en œuvre de la DCE et en particulier du test intégré du guidance 'IMPRESS’
Everbecq, Etienne ULg; Bourouag, Mohamed ULg; Deliège, Jean-François ULg et al

Report (2004)

Le modèle Pegase (Planification Et Gestion de l’ASsainissement des Eaux) est un modèle intégré bassins hydrographiques/rivières qui permet de calculer de façon déterministe et prévisionnelle la qualité ... [more ▼]

Le modèle Pegase (Planification Et Gestion de l’ASsainissement des Eaux) est un modèle intégré bassins hydrographiques/rivières qui permet de calculer de façon déterministe et prévisionnelle la qualité des eaux des rivières en fonction des rejets et apports de pollution (relation pression-impact). Développé depuis la fin des années 1980 à l’université de Liège, il permet d'orienter les choix des opérateurs publics et privés en matière de gestion des eaux de surface à l'échelle des petits et grands bassins versants. Dans la cadre de la conduite d'opération sur le bassin Moselle/Sarre que lui ont confiée les directeurs de l'eau du Rhin en janvier 2002, l'Agence de l'eau Rhin-Meuse (qui utilisait depuis plusieurs années le modèle Pegase pour ses besoins propres) a proposé aux CIPMS (Commissions Internationales pour la Protection de la Moselle et de la Sarre) de prendre en charge l'application d’une méthode de calcul des relations pressions-impacts via l’application du modèle PEGASE à l'ensemble du bassin international Moselle/Sarre. Le domaine spatial à traiter comporte plusieurs sous-domaines administratifs, avec des systèmes de coordonnées différents: Lambert belge, Lambert français, Gauss-Krüger luxembourgeois, Gauss-Krüger allemand. Chaque administration concernée transmet ses informations dans son système de coordonnées, le pré-processing PEGASE se chargeant d’effectuer les transformations de coordonnées nécessaires. Ce premier rapport présente les travaux qui ont été réalisés pour construire une première application du modèle Pégase à l’ensemble du bassin de la Moselle, bassin international (France, Allemagne, Grand-duché de Luxembourg, Belgique) [less ▲]

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See detailA Long-Term Slip-Rate Study Along The North Anatolian Fault, Eksik, Turkey Using Cosmogenic 36Cl
Kozaci, O; Dolan, J; Finkel, R et al

in EOS : Transactions, American Geophysical Union (2004, December)

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See detailCollective Motion: Bistability and Trajectory Tracking
Paley, Derek; Leonard, Naomi; Sepulchre, Rodolphe ULg

in Proceedings of the 43rd IEEE Conference on Decision and Control (2004, December)

This paper presents analysis and application of steering control laws for a network of self-propelled, planar particles. We explore together the two stably controlled group motions, parallel motion and ... [more ▼]

This paper presents analysis and application of steering control laws for a network of self-propelled, planar particles. We explore together the two stably controlled group motions, parallel motion and circular motion, for modeling and design purposes. We show that a previously considered control law simultaneously stabilizes both parallel and circular group motion, leading to bistability and hysteresis. We also present behavior primitives that enable piecewise-linear network trajectory tracking. [less ▲]

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See detailRelationships between incremental and cumulative fold growth with neotectonic examples from the southern Tianshan, China
Suppe, J; Hubert, Aurelia ULg; Wang, Xin

in EOS : Transactions, American Geophysical Union (2004, December)

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See detailLa poésie irlandaise aujourd'hui : Michael et Seamus, Medbh et Caitriona
Pagnoulle, Christine ULg

Scientific conference (2004, December)

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See detailOn the Robustness of Air-Sea Flux Estimates of Carbon Dioxide from Ocean Inversions
Mikaloff Fletcher, S. E.; Gruber, N. P.; Jacobson, A. et al

Conference (2004, December)

Inverse methods analogous to those used for atmospheric inversions have been adapted to estimate regional air-sea fluxes of carbon dioxide using ocean interior observations of dissolved inorganic carbon ... [more ▼]

Inverse methods analogous to those used for atmospheric inversions have been adapted to estimate regional air-sea fluxes of carbon dioxide using ocean interior observations of dissolved inorganic carbon and related tracers and an Ocean General Circulation Model (OGCM). We estimate seperately the preindustrial component and the component due to the anthropogenic perturbation of atmospheric carbon dioxide. Previous sensitivity studies have shown that model circulation is one of the most important sources of error in the ocean inversion. We present estimates of preindustrial and anthropogenic air-sea carbon dioxide exchange using a suite of nine different OGCM's in order to quantify the robustness of our results and explore the role of different representations of ocean circulation in the inversion. Most of the large scale features of the inverse estimates are robust across all models. The preindustrial inverse estimates generally follow the expected pattern of uptake at high latitudes and out gassing in the tropics; however, all of the models call for out gassing in the Southern Ocean between 44S and 58 S. The greatest anthropogenic carbon uptake occurs at mid- to high- latitudes, with a large anthropogenic carbon sink in the Southern Ocean, while the bulk of the anthropogenic carbon storage occurs at mid-latitudes. Preliminary results also suggest interesting, robust differences between these inverse estimates and estimates from forward model simulations. Both the preindustrial and anthropogenic carbon dioxide flux estimates are most robust at mid and high northern latitudes, except for the high latitude North Atlantic. The carbon dioxide flux estimates are most uncertain in the Southern Ocean, where the inverse estimates are strongly dependent on the rates of deep water ventilation in the OGCM. The preindustrial inverse estimates for the Indian Ocean are also sensitive to the choice of OGCM, and the anthropogenic estimates have significant uncertainties in the tropical Pacific. Over large spatial scales, inverse estimates based on different OGCM's are in better agreement than estimates based on forward simulations of the same models, but this is not necessarily true for smaller model regions. [less ▲]

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See detailAragonite Undersaturation in the High-Latitude Surface Ocean Within the 21st Century
Orr, J. C.; Fabry, Véronique ULg; Aumont, O. et al

Conference (2004, December)

The surface ocean is everywhere saturated with calcium carbonate (CaCO[SUB]3[/SUB]). Yet increasing atmospheric CO[SUB]2[/SUB] reduces ocean pH and carbonate ion concentration and thus the level of ... [more ▼]

The surface ocean is everywhere saturated with calcium carbonate (CaCO[SUB]3[/SUB]). Yet increasing atmospheric CO[SUB]2[/SUB] reduces ocean pH and carbonate ion concentration and thus the level of saturation. Here we show with ocean data and models that due to this anthropogenic acidification, some surface waters will become undersaturated within decades. When atmospheric CO[SUB]2[/SUB] reaches 550 ppmv, in year 2050 under the IS92a business-as-usual scenario, Southern Ocean surface waters begin to become undersaturated with respect to aragonite, a metastable form of CaCO[SUB]3[/SUB]. By 2100 as atmospheric CO[SUB]2[/SUB] reaches 788 ppmv, undersaturation extends throughout the entire Southern Ocean (<60[SUP]o[/SUP]S) and into the surbarctic Pacific. Meanwhile, Weddell Sea surface waters also become undersaturated with respect to calcite, the stable form of CaCO[SUB]3[/SUB]. These transient changes are much larger than seasonal, interannual, and decadal variability. They threaten high-latitude aragonite secreting organisms including cold-water corals, which provide essential fish habitat, and shelled pteropods, i.e., zooplankton that serve as an abundant food source for marine predators. [less ▲]

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See detailInnovation dans l'efficacité de la gestion administrative du personnel
Lisein, Olivier ULg

Conference given outside the academic context (2004)

Ce workshop interroge la valeur ajoutée des innovations technologiques au niveau de l'efficacité de la gestion administrative du personnel. A partir de l'exemple concret d'une entreprise liégeoise, il est ... [more ▼]

Ce workshop interroge la valeur ajoutée des innovations technologiques au niveau de l'efficacité de la gestion administrative du personnel. A partir de l'exemple concret d'une entreprise liégeoise, il est montré comment le recours à des solutions informatiques dédiées permet d'offrir une nouvelle gamme de services aux salariés, de confier aux salariés eux-mêmes la gestion d'une série de tâches relatives à leur dossier administratif et d'ainsi permettre au service du personnel d'avoir plus de temps pour mener à bien des initiatives de gestion des ressources humaines plutôt que d'administration du personnel. L'atelier a aussi pour but de questionner les meilleurs moyens de recourir à de telles solutions technologiques, notamment en fonction des publics cibles et des utilisateurs concernés par ce type d'innovations: cadres, employés, ouvriers, département RH, etc. [less ▲]

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