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See detailCerebral folate deficiency
Ramaekers, Vincent ULg; Blau, Nenad

in Developmental medicine and child neurology (2004), 46(12), 843-51

Cerebral folate deficiency (CFD) can be defined as any neurological syndrome associated with low cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF), the active folate metabolite, in the presence ... [more ▼]

Cerebral folate deficiency (CFD) can be defined as any neurological syndrome associated with low cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF), the active folate metabolite, in the presence of normal folate metabolism outside the nervous system. CFD could result from either disturbed folate transport or from increased folate turnover within the central nervous system (CNS). We report on a novel neurometabolic syndrome in 20 children, which we term 'idiopathic CFD'. Typical features became manifest from the age of 4 months, starting with marked unrest, irritability, and sleep disturbances followed by psychomotor retardation, cerebellar ataxia, spastic paraplegia, and dyskinesia; epilepsy developed in about one third of the children. Most children showed deceleration ofhead growth from the age of 4 to 6 months. Visual disturbances began to develop around the age of 3 years and progressive sensorineural hearing loss started from the age of 6 years. Neuroimaging showed atrophy of frontotemporal regions and periventricular demyelination in seven children, slowly progressive supra- and infratentorial atrophy in three children, and normal findings in the remainder. Because active folate transport to the CNS occurs through receptor-mediated folate receptor protein 1 (FR1) endocytosis, DNA sequencing of the FR1 gene was performed and found to be normal. However, CSF protein analysis revealed a non-functional FR1 protein, suspected to result from either post-translational defects of FR1 protein N-glycosylation, the presence of folate antagonists with irreversible binding, or autoantibodies blocking the folate binding site of FR1. Oral treatment with 5-formyltetrahydrofolate (folinic acid) should be started in low doses at 0.5-1mg/kg/day, but in some patients higher daily doses of folinic acid at 2-3 mg/kg/day are required to normalize CSF 5MTHF values. This proposed treatment protocol resulted in a favourable clinical response in patients identified before the age of six years while partial recovery with poorer outcome was found beyond the age of 6 years. Careful clinical and EEG monitoring should be performed 1, 3, and 6 months after the beginning of treatment. After four to six months of folinic acid treatment, CSF analysis should be repeated in order to prevent over- or under-dosage of folinic acid. Secondary forms of CFD have been recognized during chronic use of antifolate and anticonvulsant drugs and in various known conditions such as Rett syndrome, Aicardi-Goutieres syndrome, 3-phosphoglycerate dehydrogenase deficiency, dihydropteridine reductase deficiency, aromatic amino acid decarboxylase deficiency, and Kearns-Sayre syndrome. The pathogenic link between these underlying specific disease entities and the observed secondary CFD has not been resolved. [less ▲]

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See detailVirologic therapy response significantly correlates with the number of active drugs as evaluated using a LiPA HIV-1 resistance scoring system
Ziermann, Rainer; Celis, Linda; Derdelinckx, Inge et al

in Journal of Clinical Virology (2004), 31(Suppl. 1), 7-15

Background: Resistance testing is increasingly accepted as a tool in guiding the selection of human immunodeficiency virus type 1 (HIV-1) antiretroviral therapy in HIV-1 infected individuals who fail ... [more ▼]

Background: Resistance testing is increasingly accepted as a tool in guiding the selection of human immunodeficiency virus type 1 (HIV-1) antiretroviral therapy in HIV-1 infected individuals who fail their current regimen. Objectives: To descriptively compare the correlation between virologic treatment response and results using three genotypic HIV-1 drug resistance interpretation systems: the VERSANT(R) HIV-1 Resistance Assay (LiPA) system and two sequence-based interpretation systems. Study design: Specimens from 213 HIV-1-infected subjects, either starting (n = 104) or switching to (n = 109) a regimen of three or four antiretroviral drugs, were collected retrospectively at baseline and after 3 months of uninterrupted therapy. The correlation between viral load change and the number of predicted active drugs in the treatment regimen was assessed. An interpretation algorithm was recently developed to process VERSANT(R) HIV-1 Resistance Assay (LiPA) data. The number of active drugs predicted using this algorithm was rank correlated with the viral load change over a 3-month treatment period. For comparison, a similar calculation was made using two sequence-based algorithms (REGA version 5.5 and VGI GuideLines(TM) Rules 4.0), both applied on the same sequences. Results: Statistically significant (p < 0.05) correlation coefficients for each of the three HIV-1 drug resistance interpretation systems were observed in the treatment-experienced subjects on a 3-drug regimen (-0.39, -0.38, and -0.42, respectively) as well as on a 4-drug regimen (-0.33, -0.31, and -0.37, respectively). However, no significant correlation was observed in treatment-naive subjects, probably due to the very low frequency of drug resistance in these subjects. Conclusion: All three genotypic drug resistance interpretation systems (LiPA version 1, REGA version 5.5, and VGI GuideLines(TM) Rules 4.0) were statistically significantly correlated with virologic therapy response as measured by viral load testing. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailRisk factors for first-ever low back pain among workers in their first employment
Van Nieuwenhuyse, A.; Fatkhutdinova, L.; Verbeke, G. et al

in Occupational Medicine-Oxford (2004), 54(8), 513-519

Background Low back pain has been estimated to be the most costly ailment of people of working age. Both work characteristics and individual factors have been identified as risk factors. The first ... [more ▼]

Background Low back pain has been estimated to be the most costly ailment of people of working age. Both work characteristics and individual factors have been identified as risk factors. The first interaction between work characteristics and individual factors occurs when workers start in their first job. Aims To investigate work-related risk factors for first-ever low back pain in young workers in their first employment. Methods A cross-sectional analysis was performed on 278 young workers in their first employment and without a history of low back pain prior to working. Work-related physical factors, psychosocial work characteristics, individual variables and first-ever low back pain were queried by means of a questionnaire. Results About half of the workers who developed low back pain after job start did so in the first year of employment. An increased risk was observed for (i) long periods of seated work [relative risk (RR) = 3.2, 95% confidence interval (CI) = 1.6-6.4]; (ii) more than 12 flexion or rotation movements of the trunk per hour (RR = 3.0, 95% CI = 1.4-6.4); and (iii) more than 3 years seniority in a job involving lifting more than 25 kg at least once an hour (RR = 3.7, 95% CI = 1.4-9.4). As to psychosocial work characteristics, first-ever low back pain was associated with a combination of low psychological job demands and low supervisor support. Conclusion Work-related physical factors and psychosocial work characteristics should be considered as risk factors for first-ever low back pain. First-ever episodes of low back pain are common in the first year of employment. This may reflect a lack of work experience or training. [less ▲]

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See detailInformation et échanges autour de la vaccination : une expérience positive
Miermans, Marie-Christine ULg

in Promouvoir la santé à l'école (2004), (8), 3-4

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See detailSeismic Diagrams for beta Cephei stars; A database for COROT
Thoul, Anne ULg

Conference (2004, December)

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See detailMeasurement of Dioxins and WHO-PCBs in Foodstuffs using GCxGC-IDTOFMS
Focant, Jean-François ULg; De Pauw, Edwin ULg

Scientific conference (2004, December)

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See detailWealth Breeds Decline: Reversals of Leadership and Consumption Habits
Artige, Lionel ULg; Camacho, Carmen; de la Croix, David

in Journal of Economic Growth (2004), 9(4), 423-449

In a two-region model, we formalize Kindlebergerrsquos idea that wealth breeds first more wealth, and then decline: when one region leads, its inhabitants develop consumption habits incompatible with the ... [more ▼]

In a two-region model, we formalize Kindlebergerrsquos idea that wealth breeds first more wealth, and then decline: when one region leads, its inhabitants develop consumption habits incompatible with the necessary investment in knowledge to remain the leader. This gives the other region a window of opportunity to gain economic primacy. The theory suggests that differences across regions that have similar characteristics may persist even if physical capital flows from rich to poor regions. We study patterns of overtaking, alternating primacy, irreversible decline, and monotonic convergence, according to the initial dispersion of knowledge and the strength of consumption habits. Even though exogenous factors may matter on some occasions, we show that they are not necessary to reverse economic leadership. [less ▲]

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See detailLe Rwanda et ses mille collines pour une meilleure production laitière
Hanzen, Christian ULg

Conference given outside the academic context (2004)

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See detailUn homme, une vocation
Claustriaux, Jean-Jacques ULg; Nuyt, Cécile

in Echosud (2004), 5

Quelles sont les raisons pour lesquelles un universitaire s'intéresse aux pays du Sud ?

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See detailIntérêt des modèles des plus proches voisins pour le contrôle de l'hétérogénéité spatiale : application à un essai de provenances de pin d'Alep (pinus halepensis mill.) en Tunisie
Sghaier, T.; Claustriaux, Jean-Jacques ULg; Beji, A.

in Revue de l'I.N.A.T. (2004), 19(2), 5-22

To study the importance of the spatial analysis in the control of soil heterogeneity in experiment on field, three approaches of statistical analysis were applied to a total height of trees measured at 29 ... [more ▼]

To study the importance of the spatial analysis in the control of soil heterogeneity in experiment on field, three approaches of statistical analysis were applied to a total height of trees measured at 29 years of age in a comparative test of thirty origins of Aleppo pine (Pinus halepensis Mill.), autochtonous and introduced in Tunisia. Analysis without control of heterogeneity (totally random), with a global control of heterogeneity (complete blocks) and with a local control of heterogeneity (nearest neighbour models) were used. For this last approach using to estimate the plot fertility the one of the nearby plots, various combinations of neighbour were tested with one or two coefficients of regression. The obtained results showed that the reduction of the residual mean square by comparison to the analysis without control of heterogeneity is 30 % to the complete blocks analysis and varied between 66 and 79 % for spatial analysis. Significant positive correlations between plots residues and the average of the residues of the nearby plots were observed before adjustment of data. After adjustment of data by the nearest neighbour models, these correlations were registered a reduction from 92 to 95 % according to the used model. Among the six nearest neighbour models studied, the model bringing in eight neighbours with two coefficients of regression showed itself the most effective. It also seemed that after adjustment of data by nearest neighbour models, using the structure of blocks does not produce a reduction of the residual mean square. [less ▲]

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See detailA Long-Term Slip-Rate Study Along The North Anatolian Fault, Eksik, Turkey Using Cosmogenic 36Cl
Kozaci, O; Dolan, J; Finkel, R et al

in EOS : Transactions, American Geophysical Union (2004, December)

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See detailRelationships between incremental and cumulative fold growth with neotectonic examples from the southern Tianshan, China
Suppe, J; Hubert, Aurelia ULg; Wang, Xin

in EOS : Transactions, American Geophysical Union (2004, December)

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See detailLa poésie irlandaise aujourd'hui : Michael et Seamus, Medbh et Caitriona
Pagnoulle, Christine ULg

Scientific conference (2004, December)

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See detailOn the Robustness of Air-Sea Flux Estimates of Carbon Dioxide from Ocean Inversions
Mikaloff Fletcher, S. E.; Gruber, N. P.; Jacobson, A. et al

Conference (2004, December)

Inverse methods analogous to those used for atmospheric inversions have been adapted to estimate regional air-sea fluxes of carbon dioxide using ocean interior observations of dissolved inorganic carbon ... [more ▼]

Inverse methods analogous to those used for atmospheric inversions have been adapted to estimate regional air-sea fluxes of carbon dioxide using ocean interior observations of dissolved inorganic carbon and related tracers and an Ocean General Circulation Model (OGCM). We estimate seperately the preindustrial component and the component due to the anthropogenic perturbation of atmospheric carbon dioxide. Previous sensitivity studies have shown that model circulation is one of the most important sources of error in the ocean inversion. We present estimates of preindustrial and anthropogenic air-sea carbon dioxide exchange using a suite of nine different OGCM's in order to quantify the robustness of our results and explore the role of different representations of ocean circulation in the inversion. Most of the large scale features of the inverse estimates are robust across all models. The preindustrial inverse estimates generally follow the expected pattern of uptake at high latitudes and out gassing in the tropics; however, all of the models call for out gassing in the Southern Ocean between 44S and 58 S. The greatest anthropogenic carbon uptake occurs at mid- to high- latitudes, with a large anthropogenic carbon sink in the Southern Ocean, while the bulk of the anthropogenic carbon storage occurs at mid-latitudes. Preliminary results also suggest interesting, robust differences between these inverse estimates and estimates from forward model simulations. Both the preindustrial and anthropogenic carbon dioxide flux estimates are most robust at mid and high northern latitudes, except for the high latitude North Atlantic. The carbon dioxide flux estimates are most uncertain in the Southern Ocean, where the inverse estimates are strongly dependent on the rates of deep water ventilation in the OGCM. The preindustrial inverse estimates for the Indian Ocean are also sensitive to the choice of OGCM, and the anthropogenic estimates have significant uncertainties in the tropical Pacific. Over large spatial scales, inverse estimates based on different OGCM's are in better agreement than estimates based on forward simulations of the same models, but this is not necessarily true for smaller model regions. [less ▲]

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See detailAragonite Undersaturation in the High-Latitude Surface Ocean Within the 21st Century
Orr, J. C.; Fabry, Véronique ULg; Aumont, O. et al

Conference (2004, December)

The surface ocean is everywhere saturated with calcium carbonate (CaCO[SUB]3[/SUB]). Yet increasing atmospheric CO[SUB]2[/SUB] reduces ocean pH and carbonate ion concentration and thus the level of ... [more ▼]

The surface ocean is everywhere saturated with calcium carbonate (CaCO[SUB]3[/SUB]). Yet increasing atmospheric CO[SUB]2[/SUB] reduces ocean pH and carbonate ion concentration and thus the level of saturation. Here we show with ocean data and models that due to this anthropogenic acidification, some surface waters will become undersaturated within decades. When atmospheric CO[SUB]2[/SUB] reaches 550 ppmv, in year 2050 under the IS92a business-as-usual scenario, Southern Ocean surface waters begin to become undersaturated with respect to aragonite, a metastable form of CaCO[SUB]3[/SUB]. By 2100 as atmospheric CO[SUB]2[/SUB] reaches 788 ppmv, undersaturation extends throughout the entire Southern Ocean (<60[SUP]o[/SUP]S) and into the surbarctic Pacific. Meanwhile, Weddell Sea surface waters also become undersaturated with respect to calcite, the stable form of CaCO[SUB]3[/SUB]. These transient changes are much larger than seasonal, interannual, and decadal variability. They threaten high-latitude aragonite secreting organisms including cold-water corals, which provide essential fish habitat, and shelled pteropods, i.e., zooplankton that serve as an abundant food source for marine predators. [less ▲]

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See detailNew integrative method to generate Bacillus subtilis recombinant strains free of selection markers
Brans, Alain ULg; Filée, Patrice ULg; Chevigné, Andy ULg et al

in Applied and Environmental Microbiology (2004), 70(12), 7241-7250

The novel method described in this paper combines the use of blaI, which encodes a repressor involved in Bacillus licheniformis BlaP beta-lactamase regulation, an antibiotic resistance gene, and a B ... [more ▼]

The novel method described in this paper combines the use of blaI, which encodes a repressor involved in Bacillus licheniformis BlaP beta-lactamase regulation, an antibiotic resistance gene, and a B. subtilis strain (BS1541) that is conditionally auxotrophic for lysine. We constructed a BlaI cassette containing blaI and the spectinomycin resistance genes and two short direct repeat DNA sequences, one at each extremity of the cassette. The BS1541 strain was obtained by replacing the B. subtilis P(lysA) promoter with that of the P(blaP) beta-lactamase promoter. In the resulting strain, the cloning of the blaI repressor gene confers lysine auxotrophy to BS1541. After integration of the BlaI cassette into the chromosome of a conditionally lys-auxotrophic (BS1541) strain by homologous recombination and positive selection for spectinomycin resistance, the eviction of the BlaI cassette was achieved by single crossover between the two short direct repeat sequences. This strategy was successfully used to inactivate a single gene and to introduce a gene of interest in the Bacillus chromosome. In both cases the resulting strains are free of selection marker. This allows the use of the BlaI cassette to repeatedly further modify the Bacillus chromosome. [less ▲]

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See detailLa sexualité du couple vieillissant : quelle distribution des rôles ?
Kempeneers, Philippe ULg

in Patient Care, Neuropsychiatrie (2004), 4

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See detailLine profile variability in the spectra of Oef stars - II. HD192281, HD14442 and HD14434
De Becker, Michaël ULg; Rauw, Grégor ULg

in Astronomy and Astrophysics (2004), 427(3), 995-1008

We present the very first analysis of the spectroscopic variability of the three rapidly rotating Oef stars HD 192281 (O5(ef)), HD14442 (O5.5ef) and HD 14434 (O6.5( ef)). Radial velocities of the He II ... [more ▼]

We present the very first analysis of the spectroscopic variability of the three rapidly rotating Oef stars HD 192281 (O5(ef)), HD14442 (O5.5ef) and HD 14434 (O6.5( ef)). Radial velocities of the He II lambda 4541 line reveal no evidence of binarity on time scales of a few days, or from one year to the next, for any of the targets. The He II lambda 4686 double-peaked emission and, to some extent, the H absorption line display significant profile variability in the spectra of all three stars. Data gathered during different observing runs spread over six years reveal a rather stable time scale for HD 192281 and HD14442, whereas the variability pattern changes significantly from one year to the other. The case of HD 14434 is less clear as no obvious time scale emerges from our analysis. In a tentative way to interpret this variability, stellar rotation remains a possible clock for HD 192281 and HD14442. However, currently available models addressing stellar rotation fail to explain some crucial aspects of the observed variability behaviour, which appear to be even more complex in the case of HD 14434. [less ▲]

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