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See detailDesarrollo de una estrategia para la optimización de la vacuna contra el virus de la diarrea viral bovina
Zábal, O.; Wigdorovitz, A.; Parreño, V. et al

Poster (2003, December 01)

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See detailThe UVES Paranal Observatory Project: A Library of High- Resolution Spectra of Stars across the Hertzsprung-Russell Diagram
Bagnulo, S.; Jehin, Emmanuel ULiege; Ledoux, C. et al

in The Messenger (2003), 114

We present the UVES Paranal Observatory Project, consisting of acquisition, reduction, and public release of high-resolution, large wavelength coverage, and high signal-to-noise ratio stellar spectra ... [more ▼]

We present the UVES Paranal Observatory Project, consisting of acquisition, reduction, and public release of high-resolution, large wavelength coverage, and high signal-to-noise ratio stellar spectra obtained with the UVES instrument of the ESO Very Large Telescope. Data for about 400 stars across the Hertzsprung-Russell diagram have been taken and reduced by members of the Paranal Science Operations Team and made publicly available through a WEB interface at www.eso.org/uvespop. [less ▲]

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See detailEarly activation of cardiac and renal endothelin systems in experimental heart failure
Motte, S.; van Beneden, R.; Mottet, J. et al

in American Journal of Physiology - Heart and Circulatory Physiology (2003), 285(6), 2482-2491

We investigated the time course of the expression of cardiac and renal endothelin systems in tachycardia-induced heart failure in dogs. Eleven beagles underwent rapid pacing at a progressively increased ... [more ▼]

We investigated the time course of the expression of cardiac and renal endothelin systems in tachycardia-induced heart failure in dogs. Eleven beagles underwent rapid pacing at a progressively increased rate over a period of 5 wk, with a weekly clinical examination, echocardiography, measurement of circulating and urinary endothelin-1 (ET-1), and myocardial and renal tissue biopsies. Real-time quantitative PCR was used for determinations of tissue prepro-ET-1 (ppET-1), ET-1-converting enzyme (ECE-1), and ETA and ETB receptor mRNA. Cardiac and renal tissue ET-1 contents were evaluated by immunostaining and measured by radioimmunoassay at autopsy. Rapid pacing caused a progressive increase in end-systolic and end-diastolic ventricular volumes (P<0.05) from week 2 together with a decrease in ejection fraction and in mean velocity of circumferential shortening (P<0.05) from week 1. These changes were tightly correlated to myocardial ppET-1 and renal ETA receptor mRNA and less so to myocardial ECE-1 mRNA, and they occurred before any increase in plasma and urinary ET-1 (P<0.05 from week 4) and clinical signs of heart failure. Renal ppET-1 did not change. Both cardiac and renal ET-1 peptide contents were increased at autopsy. We conclude that tachycardia-induced heart failure in dogs is characterized by an early activation of the cardiac and renal tissue endothelin systems, which occurs before any changes in circulating and urinary ET-1 and is closely related to altered ventricular function. [less ▲]

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See detailThe photospheric abundances of active binaries. II. Atmospheric parameters and abundance patterns for 6 single-lined RS CVn systems
Morel, Thierry ULiege; Micela, G.; Favata, F. et al

in Astronomy and Astrophysics (2003), 412

Photospheric parameters and abundances are presented for a sample of single-lined chromospherically active binaries from a differential LTE analysis of high-resolution spectra. Abundances have been ... [more ▼]

Photospheric parameters and abundances are presented for a sample of single-lined chromospherically active binaries from a differential LTE analysis of high-resolution spectra. Abundances have been derived for 13 chemical species, including several key elements such as Li, Mg, and Ca. Two methods have been used. The effective temperatures, surface gravities and microturbulent velocities were first derived from a fully self-consistent analysis of the spectra, whereby the temperature is determined from the excitation equilibrium of the Fe I lines. The second approach relies on temperatures derived from the (B-V) colour index. These two methods give broadly consistent results for the stars in our sample, suggesting that the neutral iron lines are formed under conditions close to LTE. We discuss the reliability in the context of chromospherically active stars of various colour indices used as temperature indicators, and conclude that the (V-R) and (V-I) colours are likely to be significantly affected by activity processes. Irrespective of the method used, our results indicate that the X-ray active binaries studied are not as metal poor as previously claimed, but are at most mildly iron-depleted relative to the Sun (-0.41protect <~ [Fe/H]protect la +0.11). A significant overabundance of several chemical species is observed (e.g., the alpha -synthezised elements). These abundance patterns are discussed in relation to stellar activity. Based on observations collected at ESO (La Silla, Chile). Table A.1 is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/412/495 [less ▲]

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See detailIdentificación y caracterización de un nuevo elemento regulatorio que involucra al factor transcripcional E2F4 en la región U5 del LTR del virus de la leucosis bovina
Rodriguez, Sabrina ULiege; Varone, C.; Cánepa, E. et al

Poster (2003, December 01)

IDENTIFICACIÓN Y CARACTERIZACIÓN DE UN NUEVO ELEMENTO REGULATORIO QUE INVOLUCRA AL FACTOR TRANSCRIPCIONAL E2F-4 EN LA REGIÓN U5 DEL LTR DEL VIRUS DE LA LEUCOSIS BOVINA S. Rodriguez1, C. Varone2, E ... [more ▼]

IDENTIFICACIÓN Y CARACTERIZACIÓN DE UN NUEVO ELEMENTO REGULATORIO QUE INVOLUCRA AL FACTOR TRANSCRIPCIONAL E2F-4 EN LA REGIÓN U5 DEL LTR DEL VIRUS DE LA LEUCOSIS BOVINA S. Rodriguez1, C. Varone2, E. Cánepa2, K. Trono1 1Instituto de Virología, CICVyA. INTA – Castelar. 2Cátedra de Biologia Molecular, Facultad de Ciencias Exactas, UBA. Buenos Aires, Argentina. El genoma del virus de la leucosis bovina (VLB), como todo retrovirus, presenta en ambos extremos zonas denominadas Long Terminal Repeats (LTRs) de importancia en la regulación de la transcripción. Estas regiones están organizadas en tres zonas llamadas U3, R y U5. La región U3 ha sido ampliamente estudiada y se sabe que contiene los principales sitios que regulan la transcripción viral. Sin embargo, poco se sabe de las regiones R y U5 aunque ha quedado demostrado que ambas zonas contienen asimismo secuencias estimulatorias. Con el objetivo de identificar y caracterizar nuevos elementos regulatorios, en este trabajo se ha llevado a cabo el estudio de secuencias de las regiones R y U5 del LTR 5´ de BLV. El análisis de patrones de reconocimiento de secuencias consenso para factores de transcripción celulares en estas regiones, reveló la presencia de 2 posibles elementos de unión para E2F, ambos en la zona U5, denominados E2F-A y E2F-B, respectivamente. Para analizar la capacidad de unión a factores celulares de las secuencias LTRs se llevaron a cabo ensayos de cambio en la movilidad electroforética (EMSA) y supershift utilizando extractos celulares obtenidos a partir de linfocitos bovinos y empleando los oligonucleótidos U51 y U52 como sondas, donde mapean los elementos E2FA y E2FB, respectivamente. Se observó retardo por la formación de complejos ribo-proteicos en ambos casos pero solo en el caso del complejo U51-E2F pudo ser identificado el factor E2F-4 utilizando anticuerpos específicos. En resumen, estos resultados permiten identificar un nuevo sitio para el factor de transcripción E2F-4 localizado en la región U5 del LTR 5´ de BLV. Este motivo constituye un nuevo elemento regulatorio involucrado en la actividad transcripcional de genes virales y celulares dirigida por los LTRs y podría jugar un rol importante en la replicación viral. [less ▲]

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See detailDistintas variantes naturales del BLV presentan patrones diferenciales de unión a factores celulares
Rodriguez, Sabrina ULiege; Varone, C.; Mozgovoj, M. et al

Poster (2003, December 01)

DISTINTAS VARIANTES NATURALES DEL BLV PRESENTAN PATRONES DIFERENCIALES DE UNIÓN A FACTORES CELULARES. S. Rodriguez1, C. Varone2, M. Mozgovoj1, C. Gómez1, M.J. DusSantos1, A. Wigdorovitz1, E. Cánepa2, K ... [more ▼]

DISTINTAS VARIANTES NATURALES DEL BLV PRESENTAN PATRONES DIFERENCIALES DE UNIÓN A FACTORES CELULARES. S. Rodriguez1, C. Varone2, M. Mozgovoj1, C. Gómez1, M.J. DusSantos1, A. Wigdorovitz1, E. Cánepa2, K. Trono1 1Instituto de Virología, CICVyA, INTA – Castelar. 2Cátedra de Biologia Molecular, Facultad de Ciencias Exactas, UBA. Buenos Aires, Argentina. La relación entre el genotipo y las formas de manifestación patogénica está demostrada para ciertos Retrovirus, y las zonas regulatorias Long Terminal Repeats (LTR) han sido descriptas, entre otros factores, como portadoras de determinantes de patogenia. En el caso del Virus de la Leucosis Bovina (VLB), estudios previos de secuencias llevados a cabo en nuestro laboratorio sobre las zona R-U5 de las regiones genéticas provirales LTR aisladas de 36 animales infectados naturalmente y con diferentes formas de evolución revelaron la presencia de 4 cambios fijos y característicos de provirus aislados de linfosarcoma (LS)(100%), 1 en la región R y 3 en U5. Estas modificaciones están ausentes en la mayoría (16/22) de los provirus aislados de formas asintomáticas (AL/PL). La alta asociación entre los cambios de nucleótidos y las formas de patogenia demostró la existencia de una secuencia de nucleótidos consenso y propia de los aislados de LS en la región U5 del LTR del genoma proviral de VLB. Con el objetivo de analizar si existe una capacidad diferencial de reconocimiento de factores de regulación de la transcripción celular en la célula hospedadora de las secuencias LTRs de aislamientos de distintas formas de patogenia, se utilizaron ensayos de cambio en la movilidad electroforética (EMSA). La evaluación conjunta de los resultados demuestra que existirían diferencias específicas de unión de la región U5 a proteínas del complejo de regulación de la transcripción celular denominadas E2F en relación con las diferentes presentaciones de esta patología. Estos hallazgos aportan datos en relación con la caracterización de esta co-variación de nucleótidos como marcadores de patogenia del VLB, así como también representan un adelanto en el conocimiento de la patobiología del BLV. [less ▲]

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See detailL’audiovisuel en Belgique francophone (article sur le site internet d'Acrimed)
Geuens, Geoffrey ULiege

Article for general public (2003)

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See detailTrajectoires professionnelles féminines : flexibilités et enjeux de genre
Gavray, Claire ULiege

Doctoral thesis (2003)

Professional positions and transitions, and the capacities of autonomy which result from it, vary very significantly according to three articulated variables: the gender group, the level of certification ... [more ▼]

Professional positions and transitions, and the capacities of autonomy which result from it, vary very significantly according to three articulated variables: the gender group, the level of certification and the life course development. The gendered social hierarchisation present in every field of social insertion -although different according to generation- occupies a significant position in the construction of this course. It's important to understand objective and subjective factors (through values, choices, rôles, plans, opportunities and constraints) influencing professional paths within each gender group . These comparisons are essential. Neglecting the gender perspective and theory forbids the comprehension of the work and labor offer but also of the distribution of places on labour market. Decompartmentalization of `employment, formation, family, social capital' is also more than ever necessary to analyse individual trajectories and to imagine fieldeffective and nondiscriminating policies. For exemple, time -and its value- seems a crucial issue for the families, the citizens, the democratic society in change. [less ▲]

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See detailStabilization of periodic orbits in a wedge billiard
Sepulchre, Rodolphe ULiege; Gerard, Manuel

in Proceedings of the 42nd IEEE Conference on Decision and Control (2003, December)

This paper introduces a stabilization problem for an elementary impact control system in the plane. The rich dynamical properties of the wedge billiard, combined to the relevance of the associated ... [more ▼]

This paper introduces a stabilization problem for an elementary impact control system in the plane. The rich dynamical properties of the wedge billiard, combined to the relevance of the associated stabilization problem for feedback control issues in legged robotics make it a valuable benchmark for energy-based stabilization of impact control systems. [less ▲]

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See detailProtochlorophyllide reduction: Mechanisms and evolution
Schoefs, B.; Franck, Fabrice ULiege

in Photochemistry and Photobiology (2003), 78(6), 543-557

Protochlorophyllide (Pchlide) reductases are key enzymes in the process of chlorophyll biosynthesis. In this review, current knowledge on the molecular organization, substrate specificity and assembly of ... [more ▼]

Protochlorophyllide (Pchlide) reductases are key enzymes in the process of chlorophyll biosynthesis. In this review, current knowledge on the molecular organization, substrate specificity and assembly of the light-dependent reduced nicotinamide adenine dinucleotide phosphate:Pchlide oxidoreductases are discussed. Characteristics of light-independent enzymes are also described briefly, and the possible reasons for the selection of light-dependent enzymes during the course of evolution are discussed. [less ▲]

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See detailLCA et rééducation isocinétique : analyse critique
Croisier, Jean-Louis ULiege

in Actes de la XXIIème Journée scientifique de l’AMISEK « Controverses en chirurgie et rééducation du genou » (2003, December)

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See detailLe casier judiciaire central
Derre, Sylvie; Seron, Vincent ULiege

in Jacobs, Ann; Masset, Adrien (Eds.) Actualités de droit pénal et de procédure pénale (2003)

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See detailAdvances in the time integration of Dynamical Systems. Applications to Crashworthiness problems
Noels, Ludovic ULiege; Stainier, Laurent ULiege; Ponthot, Jean-Philippe ULiege

in Proceedings of the International Crashworthiness and Design Symposium 2003 (2003, December)

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See detailLa recherche appliquée privilégiée
Baurain, Denis ULiege

Article for general public (2003)

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See detailQuadro legal da mediaçao vitima-agressor na Europa continental
Lauwaert, Katrien ULiege

in Newsletter DGAE (2003), (2), 12-18

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See detailTowards a consistant safety format of steel beam-columns: application of the new interaction formulae for ambient temperature to elevated temperatures
Vila Real, Paulo; Lopes, Nuno; da Silva, Luis et al

in Steel & Composite Structures (2003), 3(6), 383-401

Two new formulae for the design of beam-columns at room temperature have been proposed into Eurocode 3, prEN 1993-1-1 (2002), and are the result of great efforts made by two working groups that followed ... [more ▼]

Two new formulae for the design of beam-columns at room temperature have been proposed into Eurocode 3, prEN 1993-1-1 (2002), and are the result of great efforts made by two working groups that followed different approaches, a French-Belgian team and an Austrian-German one. Under fire conditions the prEN 1993-1-2 (structural fire design) presents formulae, for the design of beam-columns based on the prENV 1993-1-1 (1992). In order to study the possibility of having, in part 1-1 and part 1-2 of the Eurocode 3, the same approach, a numerical research was made using the finite element program SAFIR, developed at the University of Liege for the study 4 structures subjected to fire. [less ▲]

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See detailPhotosynthesis and state transitions in mitochondrial mutants of Chlamydomonas reinhardtii affected in respiration
Cardol, Pierre ULiege; Gloire, Geoffrey ULiege; Havaux, M. et al

in Plant Physiology (2003), 133(4), 2010-2020

Photosynthetic activities were analyzed in Chlamydomonas reinhardtii mitochondrial mutants affected in different complexes (I, III, IV, I + III, and I + IV) of the respiratory chain. Oxygen evolution ... [more ▼]

Photosynthetic activities were analyzed in Chlamydomonas reinhardtii mitochondrial mutants affected in different complexes (I, III, IV, I + III, and I + IV) of the respiratory chain. Oxygen evolution curves showed a positive relationship between the apparent yield of photosynthetic linear electron transport and the number of active proton-pumping sites in mitochondria. Although no significant alterations of the quantitative relationships between major photosynthetic complexes were found in the mutants, 77 K fluorescence spectra showed a preferential excitation of photosystem I (PSI) compared with wild type, which was indicative of a shift toward state 2. This effect was correlated with high levels of phosphorylation of light-harvesting complex II polypeptides, indicating the preferential association of light-harvesting complex II with PSI. The transition to state 1 occurred in untreated wild-type cells exposed to PSI light or in 3-(3,4-dichlorophenyl)-1,1-dimethylurea-treated cells exposed to white light. In mutants of the cytochrome pathway and in double mutants, this transition was only observed in white light in the presence of 3-(3,4-dichlorophenyl)-1,1-dimethylurea. This suggests higher rates of non-photochemical plastoquinone reduction through the chlororespiratory pathway, which was confirmed by measurements of the complementary area above the fluorescence induction curve in dark-adapted cells. Photo-acoustic measurements of energy storage by PSI showed a stimulation of PSI-driven cyclic electron flow in the most affected mutants. The present results demonstrate that in C. reinhardtii mutants, permanent defects in the mitochondrial electron transport chain stabilize state 2, which favors cyclic over linear electron transport in the chloroplast. [less ▲]

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See detailPolymorphisms in the CYP 2D6 gene: Association with plasma concentrations of fluoxetine and paroxetine
Charlier, Corinne ULiege; Broly, Franck; Pinto, Emmanuel ULiege et al

in Therapeutic Drug Monitoring (2003), 25(6), 738-742

Most antidepressants are metabolized by cytochrome P450 (CYP) 2D6, and it is well known that there may be significant interindividual variation in the capacity to metabolize xenobiotics. About 7 to 10% of ... [more ▼]

Most antidepressants are metabolized by cytochrome P450 (CYP) 2D6, and it is well known that there may be significant interindividual variation in the capacity to metabolize xenobiotics. About 7 to 10% of whites are poor metabolisers (PM), and, on the contrary, about 5% are ultrarapid metabolizers (UM), inducing very different rates in the transformation of antidepressants extensively metabolized by CYP 2D6. CYP 2D6 polymorphism can be a potential risk factor for the development of side effects or a reason for the poor efficacy of the treatment. Various probe drugs may be used for phenotyping CYP 2D6, but genotyping is now available using leukocyte DNA and is independent of concomitant drug use. in this study, we used PCR-based methods for the identification of CYP 2D6 genotypes in 49 patients receiving standard doses of fluoxetine or paroxetine and found that plasma concentration of the antidepressant drugs was significantly correlated with genetic status. In one patient who displayed CYP 2D6 gene duplication (UM), paroxetine plasma concentration was extremely low. in PM fluoxetine-treated patients, drug plasma concentration was significantly higher than that seen in extensive metabolizers. [less ▲]

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