References of "2003"
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See detailOptimizing treatment with thioguanine derivatives in inflammatory bowel disease.
Louis, Edouard ULg; Belaiche, Jacques ULg

in Bailliere's Best Practice & Research. Clinical Gastroenterology (2003), 17(1), 37-46

Thioguanine derivatives, azathioprine and 6-mercaptopurine, represent major drugs in the treatment of chronic active inflammatory bowel disease. They are effective in two-thirds of the patients and safe ... [more ▼]

Thioguanine derivatives, azathioprine and 6-mercaptopurine, represent major drugs in the treatment of chronic active inflammatory bowel disease. They are effective in two-thirds of the patients and safe over the long term in patients who can tolerate them (80-90%). Recent progress in understanding the metabolism of these drugs and its implication in clinical practice have brought up new tools and strategies that are proposed to optimize treatment. In particular, the measurement and characterization of key enzymes and metabolites may have clinical impact. Thus, thiopurine methyl transferase genotyping and activity measurement, as well as erythrocytes, 6-thioguanine nucleotides and 6-methyl mercaptopurine levels, may help in some situations of intolerance or inefficacy with these drugs. Indications for starting and stopping treatment with thioguanine derivatives are also discussed. [less ▲]

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See detailPregnancy-Associated Glycoprotein 55h [Fragment] from Ovis aries placenta - Access number P83500
El Amiri, B.; Remy, B.; Melo de Sousa, Noelita ULg et al

E-print/Working paper (2003)

N-terminal microsequence obtained after purification and characterization of placental proteins in ovine species. Proteins were submitted to SwissProt databank.

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See detailRecognizing and interpreting the fossils of early eukaryotes
Javaux, Emmanuelle ULg; Knoll, A. H.; Walter, M.

in Origins of Life & Evolution of the Biosphere (2003), 33(1), 75-94

Using molecular sequence data, biologists can generate hypotheses of protistan phylogeny and divergence times. Fossils, however, provide our only direct constraints on the timing and environmental context ... [more ▼]

Using molecular sequence data, biologists can generate hypotheses of protistan phylogeny and divergence times. Fossils, however, provide our only direct constraints on the timing and environmental context of early eukaryotic diversification. For this reason, recognition of eukaryotic fossils in Proterozoic rocks is key to the integration of geological and comparative biological perspectives on protistan evolution. Microfossils preserved in shales of the ca. 1500 Ma Roper Group, northern Australia, display characters that ally them to the Eucarya, but, at present, attribution to any particular protistan clade is uncertain. Continuing research on wall ultrastructure and microchemistry promises new insights into the nature and systematic relationships of early eukaryotic fossils. [less ▲]

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See detailSpace-Time Adaptive Processing (STAP): an Overview
Verly, Jacques ULg

Scientific conference (2003)

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See detailAnatomische, histologische en immunologische aspecten van de tonsille bij het schaap in het kader van de BSE problematiek
Cocquyt, G.; Gabriel, Annick ULg; Van den Broeck, W.

in Vlaams Diergeneeskundig Tijdschrift (2003), 72

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See detailRegulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells.
Mottet, Denis ULg; Dumont, Valery; Deccache, Yann et al

in Journal of Biological Chemistry (2003), 278(33), 31277-85

Hypoxia initiates an intracellular signaling pathway leading to the activation of the transcription factor hypoxia-inducible factor-1 (HIF-1). HIF-1 activity is regulated through different mechanisms ... [more ▼]

Hypoxia initiates an intracellular signaling pathway leading to the activation of the transcription factor hypoxia-inducible factor-1 (HIF-1). HIF-1 activity is regulated through different mechanisms involving stabilization of HIF-1alpha, phosphorylations, modifications of redox conditions, and interactions with coactivators. However, it appears that some of these steps can be cell type-specific. Among them, the involvement of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway in the regulation of HIF-1 by hypoxia remains controversial. Here, we investigated the activation state of PI3K/Akt/glycogen synthase kinase 3beta (GSK3beta) in HepG2 cells. Increasing incubation times in hypoxia dramatically decreased both the phosphorylation of Akt and the inhibiting phosphorylation of GSK3beta. The PI3K/Akt pathway was necessary for HIF-1alpha stabilization early during hypoxia. Indeed, its inhibition was sufficient to decrease HIF-1alpha protein level after 5-h incubation in hypoxia. However, longer exposure (16 h) in hypoxia resulted in a decreased HIF-1alpha protein level compared with early exposure (5 h). At that time, Akt was no longer present or active, which resulted in a decrease in the inhibiting phosphorylation of GSK3beta on Ser-9 and hence in an increased GSK3beta activity. GSK3 inhibition reverted the effect of prolonged hypoxia on HIF-1alpha protein level; more stabilized HIF-1alpha was observed as well as increased HIF-1 transcriptional activity. Thus, a prolonged hypoxia activates GSK3beta, which results in decreased HIF-1alpha accumulation. In conclusion, hypoxia induced a biphasic effect on HIF-1alpha stabilization with accumulation in early hypoxia, which depends on an active PI3K/Akt pathway and an inactive GSK3beta, whereas prolonged hypoxia results in the inactivation of Akt and activation of GSK3beta, which then down-regulates the HIF-1 activity through down-regulation of HIF-1alpha accumulation. [less ▲]

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See detailPreliminary Results from Recent Simultaneous Chandra/HST Observations of Jupiter Auroral Zones
Elsner, R. F.; Gladstone, G. R.; Waite, J. H. et al

Poster (2003)

Jupiter was observed by the Chandra X-ray Observatory in late February, 2003, for 144 ks, using both the ACIS-S and HRC-I imaging x-ray cameras. Five orbits of HST STIS observations of the planet's ... [more ▼]

Jupiter was observed by the Chandra X-ray Observatory in late February, 2003, for 144 ks, using both the ACIS-S and HRC-I imaging x-ray cameras. Five orbits of HST STIS observations of the planet's northern auroral zone were obtained during the ACIS-S observations. These data are providing a wealth of information about Jupiter's auroral activity, including the first x-ray spectra from the x-ray hot spots inside the auroral ovals. We will also discuss time variability in the auroral x-ray emission and a possible phase relation between the emission from the northern and southern x-ray aurora. [less ▲]

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See detail“Ou plutôt” : la métaphore exp(l)osée
Durand, Pascal ULg

in Ishii, Y.; Tachibana, H. (Eds.) Maldoror hier et aujourd’hui. Lautréamont : du romantisme à la modernité (2003)

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See detailSpecial issue on properties of concrete and behavior of concrete columns subjected to fire
Franssen, Jean-Marc ULg

in Fire Technology (2003), 39(1), 97

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See detailGlycoprotein Ib and integrin alphaIIbbeta3 contribute to GPVI-dependent vWF-collagen induced thrombus formation under flow
Kuijpers, Marijke; Oury, Cécile ULg; Schulte, V. et al

in Journal of Thrombosis and Haemostasis (2003)

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See detailLes délinquants sexuels : théories, évaluation et traitements
Cornet, Jean-Philippe; Giovannangeli, Daniel ULg; Mormont, Christian ULg

Book published by Frison-Roche (2003)

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See detailA simple intra ocular lens delivery system
GALAND, Albert; DEBRY, Marie-Astrid ULg; XHAUFLAIRE, Gaël ULg

Conference (2003)

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See detailL’herpèsvirose canine
Ronsse, V.; Poulet, H.; Verstegen, J. et al

in Annales de Médecine Vétérinaire (2003), 147(2, APR-MAY), 65

Canine herpesvirus is known to be a causal agent of reproduction disorders and diseases of the upper respiratory system. Subclinical infections are also frequently observed. The interest for the virus has ... [more ▼]

Canine herpesvirus is known to be a causal agent of reproduction disorders and diseases of the upper respiratory system. Subclinical infections are also frequently observed. The interest for the virus has risen in recent years especially since latency has been demonstrated and a new vaccine has been developed. In this review article we will successively deal with virus characteristics, epidemiology, pathogenesis, clinical signs, diagnosis as well as therapy and prevention. [less ▲]

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See detailKarsts en roches cristallines silicatées non carbonatées. Cas dans des gneiss : la grotte de Mfoula, Sud Cameroun
Willems, Luc ULg; Pouclet, André; Vicat, Jean-Paul

in Actes des Journées Européennes de l'AFK 2003 (2003)

Since the Seventies, a séries of phenomena developed in non carbonated silicated rocks question the traditional vision of karst. The term of karst is used in the meaning of "any feature of the classical ... [more ▼]

Since the Seventies, a séries of phenomena developed in non carbonated silicated rocks question the traditional vision of karst. The term of karst is used in the meaning of "any feature of the classical karst morphology (caves, sink-holes, lapiaz...) where dissolution plays the main genetic action and this in any kind of rocks". The cave of Guéssédoundou illustrâtes a karst in métagabbros. It opens at the top of a small hill, in a dépression twenty meters long and three to four meters deep. The walls of this dépression are subvertical and the bottom is partially occupied by angular pluridecimetric blocks. The cave is opened on several meters in the southern side of the dépression and is prolonged in the form of too narrow conduits to be explore. The bedrock is a metagabbro with fine grains, slightly weathered, crossed by decimetric quartzose veins. Gabbroïc texture is preserved, as well as part of magmatic plagioclases. The remainder is transformed into a mixture of white feldspar and clinozoisite. Pyroxene are pseudomorphosed in actinote and chlorite. The site dépression was created along a N 10° shear zone where rocks suffered important fracturation and fluid transfers, as shown by its silification and ferruginisation.. Moreover, a East-West schistosity, former to shearing, structures the gabbro. The présence of angular blocks of variable size and the absence of human activity trace on the site show that the dépression was formed naturally by collapse of the roof of a more vast cavity whose current cave would be the visible residual prolongation. The absence of flow traces and mechanical abrasion means that this cavity is due only to chemical érosion . At the cave entry and on the subvertical walls of the dépression were formed by alveoli a few centimètres to a few décimètres in diameter. Thèse alveoli of wall are known in other lithologies, in particular in limestones. The absence of salts within the rock draws aside a formation by sait weathering. The smooth aspect and non fractured walls of the cells cannot resuit from a corrosion to a fracturing node. The closed aspect of the dépression and the absence of flow trace eliminate the assumptions from formation by water swirls or eolisation. The genesis of the cave must be earlier to the installation of a weathering cover since the rock is little deteriorated and the alveoli are not developed on a quite particular level which would correspond to a précise pedogenic horizon. Only a generalized dissolution of the métagabbros, in relation to a slow solution circulation, being carried out with the favour of the fracturing plans of the shearing zone makes it possible to explain the formation of the alveoli. The inversion of relief results from a weaker érosion of the rocks made more résistant to this place by the quartz seam mainstay and by the ferruginisation along the shearing zone. In the other hand, the crushed rocks, become porous, drained the infiltrations of meteoric water, facilitating the dissolution processes. The study of the site of Guéssédoundou shows that karstic phenomena can also exist in silico-aluminous formations of crystalline rocks [less ▲]

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See detailL'importance économique du bénévolat associatif en Belgique
Mertens de Wilmars, Sybille ULg

in Non Marchand : Management, Droit et Finance (2003), (11), 9-22

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See detailLe délai de prescription de l'action civile résultant d'une infraction : fin d'une controverse
Monville, Pierre ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailDavid Malouf
Delrez, Marc ULg

in Schlager, Nigel; Lauer, Josh (Eds.) Contemporary Novelists (2003)

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See detailIncidence and survival rate of women with cervical cancer in the Greater Amsterdam area.
BULK, Saskia ULg; Visser, O.; Rozendaal, L. et al

in British journal of cancer (2003), 89(5), 834-9

To evaluate the effect of population-based cervical cancer screening on the occurrence of cervical cancer in The Netherlands, we investigated the incidence and survival of cervical cancer registered by a ... [more ▼]

To evaluate the effect of population-based cervical cancer screening on the occurrence of cervical cancer in The Netherlands, we investigated the incidence and survival of cervical cancer registered by a cancer registry in the Greater Amsterdam area. The incidence rate of squamous cell carcinoma decreased significantly from 9.2/100,000 women in 1988 to 5.9/100,000 in 2000 (P<0.001). The incidence rate of adenocarcinomas remained stable. After adjustment for age, stage and lymph node involvement, the relative risk of death was 1.6 times higher for patients with adenocarcinomas than for patients with squamous cell carcinoma (95% CI 1.2-2.1). The decreased survival was related to histological type, as the effect remained significant after correction for confounding factors. Over time, the prognosis of women with squamous cell carcinoma improved significantly. No significant change was observed for women diagnosed with adenocarcinoma. These results suggest that the screening programme in The Netherlands as executed in the Greater Amsterdam area is associated with a decreased incidence and increased survival of patients with squamous cell carcinoma, but fails to detect (pre)malignant lesions of adenocarcinoma. Since more than 92% of adenocarcinomas and its precursors contain high-risk HPV, adding HPV testing to cytologic screening might improve the present screening programme in detecting adenocarcinoma and its precursor lesions. [less ▲]

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