References of "2003"
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See detailVerbes centraux du dispositif des chartes médiévales : essai d'analyse
Boutier, Marie-Guy ULg

in Sánchez Miret, Fernando (Ed.) Actas del XXIII Congreso internacional de lingüística y filología románica (2003)

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See detailLe traitement et la gestion du cheval hépatique
Amory, Hélène ULg

in Proceedings of the Annual meeting of the French Equine Veterinary Association (AVEF) (2003)

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See detailLipides, dépression et suicide
Colin, A.; Reggers, Jean ULg; Castronovo, Vincenzo ULg et al

in Encéphale (L') (2003), 29(1, JAN-FEB), 49-58

Polyunsatured fatty acids are made out of a hydrocarbonated chain of variable length with several double bonds. The position of the first double bond (omega; omega) differentiates polyunsatured omega3 ... [more ▼]

Polyunsatured fatty acids are made out of a hydrocarbonated chain of variable length with several double bonds. The position of the first double bond (omega; omega) differentiates polyunsatured omega3 fatty acids (for example : alpha-linolenic acid or alpha-LNA) and polyunsatured omega6 fatty acids (for example : linoleic acid or LA). These two classes of fatty acids are said to be essential because they cannot be synthetised by the organism and have to be taken from alimentation. The omega3 are present in linseed oil, nuts, soya beans, wheat and cold water fish whereas omega6 are present in maize, sunflower and sesame oil. Fatty acids are part of phospholipids and, consequently, of all biological membranes. The membrane fluidity, of crucial importance for its functionning, depends on its lipidic components. Phospholipids composed of chains of polyunsatured fatty acids increase the membrane fluidity because, by bending some chains, double bonds prevent them from compacting themselves perfectly. Membrane fluidity is also determined by the phospholipids/free cholesterol ratio, as cholesterol increases membrane viscosity. A diet based on a high proportion of essential polyunsatured fatty acids (fluid) would allow a higher incorporation of cholesterol (rigid) in the membranes to balance their fluidity, which would contribute to lower blood cholesterol levels. Brain membranes have a very high content in essential polyunsatured fatty acids for which they depend on alimentation. Any dietary lack of essential polyunsatured fatty acids has consequences on cerebral development, modifying the activity of enzymes of the cerebral membranes and decreasing efficiency in learning tasks. Epidemiological data - The prevalence of depression seems to increase continuously since the beginning of the century. Though different factors most probably contribute to this evolution, it has been suggested that it could be related to an evolution of alimentary patterns in the Western world, in which polyunsatured omega fatty acids contained in fish, game and vegetables have been largely replaced by polyunsatured omega6 fatty acids of cereal oils. Some epidemiological data support the hypothesis of a relation between lower depression and/or suicide rates and a higher consumption of fish. These data do not however prove a relation of causality. Cholesterol and depression - Several cohort studies (on nondepressed subjects) have assessed the relationship between plasma cholesterol and depressive symptoms with contradictory results. Though some results found a significant relationship between a decrease of total cholesterol and high scores of depression, some other did not. Studies among patients suffering from major depression signalled more constantly an association between low cholesterol and major depression. Besides, some trials showed that clinical recovery maybe associated with a significant increase of total cholesterol. Cholesterol and suicidal behaviour - The hypothesis that a low cholesterol level may represent a suicidal risk factor was discovered accidentally following a series of epidemiological studies which revealed an increase of the suicidal risk among subjects with a low cholesterol level. Though some contradictory studies do exist, this relationship has been confirmed by several subsequent cohort studies. These findings have challenged the vast public health programs aimed at promoting the decrease of cholesterol, and even suggested to suspend the administration of lipid lowering drugs. Recent clinical studies on populations treated whith lipid lowering drugs showed nevertheless a lack of significant increase of mortality, either by suicide or accident. In addition, several controlled studies among psychiatric patients revealed a decrease of the concentrations of plasma cholesterol among patients who had attempted suicide in comparison with other patients. Polyunsaturated fatty acids and depression - In major depression, all studies revealed a significant decrease of the polyunsaturated omega3 fatty acids and/or an increase of the omega6/omega3 ratio in plasma and/or in the membranes of the red cells. In addition, two studies found a higher severity of depression when the level of polyunsaturated omega fatty acids or the ratio omega3/omega6 was low. Parallel to these modifications, other biochemical perturbations have been reported in major depression, particularly an activation of the inflammatory response system, resulting in an increase of the pro-inflammatory cytokines (interleukins: IL-1beta, IL-6 and interferon gamma) and eicosanoids (among others, prostaglandin E2) in the blood and the CSF of depressed patients. These substances cause a peroxidation and, consequently a catabolism of membrane phospholipids, among others those containing polyunsaturated fatty acids. The cytokines and eicosanoids derive from polyunsaturated fatty acids and have opposite physiological functions according to their omega or omega6 precursor. Arachidonic acid (omega6) is, among others, precursor of pro-inflammatoty prostaglandin E2 (PGE2), whereas polyunsaturated W fatty acids inhibit the formation of PGE2. It has been shown that a dietary increase of polyunsaturated W fatty acids reduced strongly the production of IL-1beta, IL-2, IL-6 and TNF-alpha (tumor necrosis factor-alpha). In contrast, diets with a higher supply of linoleic acid (omega6) increased significantly the production of pro-inflammatory cytokines, like TNF-alpha. Therefore, polyunsaturated omega3 fatty acids could be associated at different levels in the pathophysiology of major depression, on the one hand through their role in the membrane fluidity which influences diverse steps of neurotransmission and, on the other hand, through their function as precursor of pro-inflammatory cytokines and eicosanoids disturbing neurotransmission. In addition, antidepressants could exhibit an immunoregulating effect by reducing the release of pro-inflammatory cytokines, by increasing the release of endogenous antagonists of pro-inflammatory cytokines like IL-10 and, finally, by acting like inhibitors of cyclo-oxygenase. Therapeutic use of fatty acids - Data available concerning the administration of supplements of DHA (docosahexanoic acid) or other polyunsaturated fatty acids omega3 are limited. In a double blind placebo-controlled study on 30 patients with bipolar disorder, the addition of polyunsaturated omega3 fatty acids was associated with a longer period of remission. Moreover, nearly all the other prognosis measures were better in the omega3 group. Very recently, a controlled trial showed the benefits of adding an omega3 fatty acid, eicosopentanoic acid, among depressed patients. After 4 weeks, six of the 10 patients receiving the fatty acid were considered as responders in comparison with only one of the ten patients receiving placebo. Conclusions Some epidemiological, experimental and clinical data favour the hypothesis that polyunsaturated fatty acids could play a role in the pathogenesis and/or the treatment of depression. More studies however are needed in order to better precise the actual implication of those biochemical factors among the various aspects of depressive illness. [less ▲]

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See detail« Comment servir le souverain ». A propos d’un traité pseudo-platonicien inédit
Bauden, Frédéric ULg; Ghersetti, Antonella

in Quaderni di Studi Arabi (2003), 20-21

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See detailThe neuroendocrinology of reproductive behavior in Japanese quail
Balthazart, Jacques ULg; Baillien, Michelle; Charlier, Thierry ULg et al

in Domestic Animal Endocrinology (2003), 25

Sex steroid hormones such as testosterone have widespread effects on brain physiology and function but one of their best characterized effects arguably involves the activation of male sexual behavior ... [more ▼]

Sex steroid hormones such as testosterone have widespread effects on brain physiology and function but one of their best characterized effects arguably involves the activation of male sexual behavior. During the past 20 years we have investigated the testosterone control of male sexual behavior in an avian species, the Japanese quail (Coturnix japonica).We briefly reviewhere the main features and advantages of this species relating to the investigation of fundamental questions in the field of behavioral neuroendocrinology, a field that studies inter-relationship among hormones, brain and behavior. Special attention is given to the intracellular metabolism of testosterone, in particular its aromatization into an estrogen, which plays a critical limiting role in the mediation of the behavioral effects of testosterone. Brain aromatase activity is controlled by steroids which increase the transcription of the enzyme, but afferent inputs that affect the intraneuronal concentrations of calcium also appear to have a pronounced effect on the enzyme activity through rapid changes in its phosphorylation status. The physiological significance of these slowgenomic and rapid, presumably non-genomic, changes in brain aromatase activity are also briefly discussed. [less ▲]

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See detailOrion : de la météorologie à la mythologie
Renaud, Jean-Michel ULg

in Cusset, Christophe (Ed.) La météorologie dans l'Antiquité : entre science et croyance. Actes du Colloque International Interdisciplinaire de Toulouse. 2-3-4 mai 2002 (2003)

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See detailDeciphering the impaired cytokine cascades in chronic leg ulcers (review).
Quatresooz, Pascale ULg; Henry, Frédérique ULg; Paquet, Philippe ULg et al

in International Journal of Molecular Medicine (2003), 11(4), 411-8

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis ... [more ▼]

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis. The various cytokines identified in experimental wounds are also present in leg ulcers. VEGF is strongly implicated as a promoter of blood vessel growth in patients with venous disease. In addition, there is good evidence of increased expression of bFGF, TGF-beta1, and PDGF in lipodermatosclerosis. All of these growth factors are involved in wound healing. Upregulated TGF-beta1 is probably one of the main causes of the fibrosis observed in lipodermatosclerosis. In leg ulcers, cytokines appear to be trapped in the perivascular fibrinoid deposits. It is not the nature and amount of cytokines that are inadequate in leg ulcers, but rather their spatial distribution. Dermal dendrocytes (DD) are resident factor XIIIa-enriched macrophages. They likely play a role in tissue repair when boosted adequately. New therapies aiming at helping the release of cytokines by DD apparently promote and improve the healing phase. [less ▲]

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See detailLe règlement transactionnel
Leleu, Yves-Henri ULg

in Weyts, L.; Verbeke, A.; Goovaerts, E. (Eds.) Actualia familiaal vermogensrecht (2003)

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See detailLe gigantisme : Un mystère élucidé
Beckers, Albert ULg

in Louvain Medical (2003), 122(6), 241-248

L'acromégalie a été décrite par Pierre Marie en 1886. Peu de temps après, il est devenu clair que le gigantisme et l'acromégalie ont la même étiologie: une hypersécrétion d'hormone de croissance, la ... [more ▼]

L'acromégalie a été décrite par Pierre Marie en 1886. Peu de temps après, il est devenu clair que le gigantisme et l'acromégalie ont la même étiologie: une hypersécrétion d'hormone de croissance, la plupart du temps par un adénome hypophysaire, produit un géant si elle a lieu avant l'âge adulte et un acromégale si elle survient après la puberté. Au cours du XXe siècle, cette affection sera caractérisée et divers traitements efficaces mis au point. A la fin du siècle, les mécanismes génétiques responsables de la maladie seront élucidés. [less ▲]

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See detailİzmir Gezisi: Antoine Galland'ın Bir Elyazması (1678)
Galland, Antoine; Bauden, Frédéric ULg; Üyepazarcı, Erol

Book published by İzmir Büyükşehir Belediyesi Kültür Yayını (2003)

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See detailUtilisation des scories métallurgiques en dynamique fluviale : détermination de la compétence effective des rivières et estimation des vitesses de progression de la charge de fond.
Houbrechts, Geoffrey ULg; Petit, François ULg

in Géomorphologie : Relief, Processus, Environnement (2003), (1), 3-12

Les compétences effectives de trois rivières du nord de l’Ardenne (Belgique) ont pu être estimées grâce à la présence de nombreuses macroscories dans leur charge de fond. En effet, ces scories, rejetées ... [more ▼]

Les compétences effectives de trois rivières du nord de l’Ardenne (Belgique) ont pu être estimées grâce à la présence de nombreuses macroscories dans leur charge de fond. En effet, ces scories, rejetées par les anciens fondeurs dans les rivières, ont été soumises, pendant plusieurs siècles, à de nombreuses crues mobilisatrices. Par conséquent, elles peuvent être considérées comme un marqueur représentatif de la compétence effective des rivières sur une très longue période et sur une grande distance. Ainsi, en comparant la taille des scories en amont et en aval d’un secteur de pertes karstiques (plusieurs kilomètres), nous avons montré que ces pertes n’entraînent pas de baisse sensible de la compétence de la rivière. Une relation entre la taille des scories prélevées et les puissances spécifiques développées dans les secteurs de prélèvement a également été établie. Cette relation montre que le maximum de puissance spécifique des rivières ardennaises se produit dans les rivières dont le bassin versant est voisin de 150 km². Finalement, des scories retrouvées dans l’Ourthe, environ 10 km en aval du site de production le plus proche, ont été utilisées pour évaluer la vitesse de progression de la « vague sédimentaire ». En effet, ces scories sont soumises aux mêmes conditions hydrologiques et de piégeage que les éléments naturels de la charge de fond. Après avoir daté le début du fonctionnement du site de production le plus proche (1450), nous avons calculé la vitesse de progression des scories qui est comprise entre 1,8 et 2,3 km/siècle. [less ▲]

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See detailA Framework For Humanoid Control and Intelligence
Platt, Robert; Brock, Oliver; Fagg, Andrew et al

in Proceedings of the IEEE International Conference on Humanoid Robots (2003)

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See detailBases neurobiologiques et psychopharmacologiques
Scuvée-Moreau, Jacqueline ULg; Seutin, Vincent ULg; Van den Berghe, Marc

in Dierick, Michel; Ansseau, Marc; D'Haenen, Hugo (Eds.) et al Manuel de Psychopharmacothérapie (2003)

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See detail3-Isopropylamino-7-nitro-1,4,2-benzodithiazine 1,1-dioxide
Dupont, L.; Somers, F.; De Tullio, Pascal ULg et al

in Acta Crystallographica (2003)

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See detailEvolutionary ecology of paedomorphosis in the Alpine newt Triturus alpestris
Denoël, Mathieu ULg

Conference (2003)

Paedomorphosis, in which individuals retain ancestral characteristics in the adult stage, is widespread in newts and salamanders and is suspected to play an important role in evolution. In some species ... [more ▼]

Paedomorphosis, in which individuals retain ancestral characteristics in the adult stage, is widespread in newts and salamanders and is suspected to play an important role in evolution. In some species, paedomorphosis is facultative with some individuals skipping the metamorphic stage. Dimorphic populations of the Alpine newt inhabit a large variety of aquatic habitats such as permanent lakes and temporary ponds. The aim of this study was to determine the benefits of the alternatives in these different habitats. To this end, I focused on resource partitioning, energy intake, body condition and age structures in different populations composed of the two morphs. In deep lakes, there was a substantial trophic differentiation between morphs. Paedomorphs primarily preyed on plankton whereas metamorphs foraged on terrestrial invertebrates that fell to the water surface. By reducing competition, resource partitioning may contribute to the coexistence of the alternative morphs in heterogeneous habitats. On the contrary, in a small pond, resource use was similar in the two morphs. Maturity is reached earlier in the paedomorphs from this small pond than in metamorphs (progenetic process), favoring then a rapid turn-over of the population, while similar gonadal development was observed in one of the deep lakes (neotenic process). Body condition was generally higher in paedomorphs than in metamorphs in each studied population. These results show that facultative paedomorphosis is adaptive in varied habitats, but that different factors may favor it depending of the characteristics of the environment. Paedomorphic phenotypes can thus be selected in low altitude productive ponds and high altitude oligotrophic lakes. [less ▲]

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See detailVariations sur l'appel des ordonnances 'sur référé'
Boularbah, Hakim ULg

in Imperat Lex - Liber amicorum Pierre Marchal (2003)

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See detailDoes Export Controls Regimes could Contribute to Counter the Acquisition of WMD by Sub-national ?,
Michel, Quentin ULg

in Bulletin de l'Académie Royale des Sciences, des Lettres et des Beaux-Arts de Belgique. Sciences (2003)

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See detailFungal lectin, XCL, is internalized via clathrin-dependent endocytosis and facilitates uptake of other molecules.
Francis, Frédéric ULg; Marty-Detraves, Claire; Poincloux, Renaud et al

in European Journal of Cell Biology (2003), 82(10), 515-22

The lectin isolated from Xerocomus chrysenteron (XCL) displays a toxic activity towards insects. In order to assess its possible mode of action and to gather useful data for its potential use in insect ... [more ▼]

The lectin isolated from Xerocomus chrysenteron (XCL) displays a toxic activity towards insects. In order to assess its possible mode of action and to gather useful data for its potential use in insect-resistant transgenic plants, we investigated the effects of XCL at the cellular level. Immunofluorescence microscopy studies revealed that XCL is rapidly internalized into small endocytic vesicles that further coalesce in the perinuclear region. We show that XCL is endocytosed by the clathrin-dependent pathway, and is delivered to late endosome/lysosome compartments. The internalization of XCL seems to be general since it occurs in different cell types such as insect (SF9) or mammalian (NIH-3T3 and Hela) cell lines. In the presence of XCL, the uptake of GFP and BSA is greatly enhanced, demonstrating that XCL facilitates endocytosis. Thus, XCL could serve as a delivery agent to facilitate the endocytosis of proteins that do not enter the cell alone. [less ▲]

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