References of "2003"
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See detailL’expérience politique des jeunes, par Anne Muxel (compte rendu)
Fournier, Bernard ULg

in Politique et Sociétés (2003), 22(2)

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See detailFoam imbibition in microgravity - An experimental study
Caps, Hervé ULg; Decauwer, H.; Chevalier, M. L. et al

in European Physical Journal B -- Condensed Matter (2003), 33(1), 115-119

We report an experimental study of aqueous foam imbibition in microgravity with strict mass conservation. The foam is in a Hele-Shaw cell. The bubble edge width l is measured by image analysis. The ... [more ▼]

We report an experimental study of aqueous foam imbibition in microgravity with strict mass conservation. The foam is in a Hele-Shaw cell. The bubble edge width l is measured by image analysis. The penetration of the liquid in the foam, the foam imbibition, the foam inflation, and the rigidity loss are shown all to obey strict diffusion processes. The motion of bubbles needed for the foam inflation is a slow two-dimensional process with respect to the one-dimensional capillary rise of liquid. The foam is found to imbibes faster than it inflates. [less ▲]

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See detailScreening of histone deacetylase (HDAC) expression profiles in prostate cancer tissues leads to the identification of HDAC8 as a novel marker of smooth muscle differentiation
Waltregny, David ULg; Glénisson, Wendy; Tran, Syv Li et al

Conference (2003)

Background: Histone deacetylation mediated by histone deacetylases (HDAC) plays a key role in the regulation of gene expression. Inhibition of HDAC activity is associated with profound alterations in ... [more ▼]

Background: Histone deacetylation mediated by histone deacetylases (HDAC) plays a key role in the regulation of gene expression. Inhibition of HDAC activity is associated with profound alterations in cellular biology, such as cell growth arrest, apoptosis and differentiation. It has been hypothesized that altered HDAC expression and/or activity could play a role in cancer development and progression. Objectives: To investigate this possibility, we undertook a study in which we screened HDAC expression profiles in human prostate cancer. In addition, we sought to determine the specific biological effects of selected HDACs. Methods: A variety of techniques, including immunochemistry, Q-RT-PCR, and immunobloting, were used to examine the expression of several class I and class II HDACs in human prostate cancer cell lines and matched malignant and non-malignant prostate tissues. Analysis of the specific biological effects of selected HDACs was performed after knocking down their expression with the use of specific small interfering RNAs (siRNA) and/or after forcing their overexpression by transfection of the cDNAs of interest. Results: Normal prostate epithelial and stromal cells displayed distinct HDAC expression profiles, suggesting specific functions for these enzymes in the prostate. Human prostate cancer cells did not exhibit significant alterations in the abundance of any of the HDAC enzymes analyzed. One of the HDACs tested, herein referred to as HDACX, was specifically expressed, in vivo, by cells showing smooth muscle phenotype, including vascular and prostate smooth muscle cells and myoepithelial cells. HDACX expression co-localized with the expression of the specific smooth muscle marker alpha smooth muscle actin (alpha-SMA) in all human tissues tested. Nucleo-cytoplasmic fractionation experiments showed that HDACX was mainly expressed in the cytosol of human smooth muscle cells (HSMC) obtained from umbilical cord veins. Transfection experiments leading to overexpression of HDACX in mouse fibroblasts indicated that the enzyme was detected both in the cytosol and in the nucleus. By immunocytochemistry, it was observed that HDACX pattern of expression was reminiscent of actin stress fibers, suggesting that this HDAC may be involved in the regulation of the smooth muscle cell cytoskeleton. Trichostatin A (TSA), a specific global HDAC inhibitor, as well as specific HDACX siRNAs, were able to completely prevent the TGFß1-induced differentiation of fibroblasts into myofibroblasts, as assessed by alpha-SMA abundance. Forced downregulation of HDACX by siRNAs in HSMC caused a dramatic reduction in their contraction capacity, as determined with the use of hydrated collagen lattices contraction assays. Conclusions : HDACs diplay distinct expression profiles among normal prostate epithelial and stromal cells. The abundance of the HDACs analyzed in this study is not altered in prostate cancer. Further experiments are required to determine whether the activity of these enzymes is altered in prostate cancer. We have identified for the first time an HDAC that (i) is specifically expressed in cells showing smooth muscle phenotype, (ii) is required for myofibroblastic differentiation, and (iii) is involved in smooth muscle cell contraction. This HDAC may become a target for the therapy of several pathological conditions, including chronic inflammation and cancer, in which myofibroblasts play a major role. [less ▲]

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See detailEtat des lieux. L’espagnol, l’italien et les autres langues romanes en Belgique francophone
Fabry, Geneviève; Lucchini, Silvia ULg

in Collès, L.; Dufays, J.-L.; Maeder, C. (Eds.) Enseigner le français, l'espagnol et l'italien. (2003)

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See detailEvaluation of false transrectal ultrasonographic pregnancy diagnoses in sheep by measuring the plasma level of pregnancy-associated glycoproteins
Karen, A.; Beckers, Jean-François ULg; Sulon, Joseph ULg et al

in Reproduction Nutrition Development (2003), 43(6, NOV-DEC), 577-586

The present study was undertaken to investigate to what extent pregnancy diagnoses made by transrectal ultrasonography could be confirmed by measurements of plasma concentration of ovine pregnancy ... [more ▼]

The present study was undertaken to investigate to what extent pregnancy diagnoses made by transrectal ultrasonography could be confirmed by measurements of plasma concentration of ovine pregnancy-associated glycoproteins (ovPAG). A total of 424 Awassi x Merino ewes were synchronized for estrus and examined by transrectal ultrasonography. In Experiment 1, the ewes (n = 156) were repeatedly scanned in a standing position on d 29, 36 and 50 of gestation. Similarly, the ewes (n = 268) in Experiment 2 were scanned on d 24, 29 and 34 of gestation, but these ewes were fasted for 12 h prior to the examination and the abdominal wall of each animal was lifted up by the hands of the assistant during the scanning. Blood samples were withdrawn after each transrectal ultrasonographic examination in both experiments. Ovine PAG concentrations were measured in plasma by a heterologous radioimmunoassay and the cut-off value for pregnancy was greater than or equal to 1 ng.mL(-1). Based on the lambing performance, in Experiment 1, altogether 47 false negative and 38 false positive diagnoses were made by transrectal ultrasonography in 24 and 33 ewes, respectively between d 29 and 50 of gestation. In Experiment 2, altogether 8 false negative and 13 false positive diagnoses both were made in 7 ewes between d 24 and 34 of gestation. In both experiments, all ewes with false negative diagnoses had ovPAG concentrations higher than the threshold level for pregnancy diagnosis and all ewes with false positive diagnoses had ovPAG concentrations lower than the threshold of pregnancy. Furthermore, by the PAG-RIA test all lambed or aborted ewes (n = 63) were correctly diagnosed as pregnant and with three exceptions, all non-lambed ewes (n = 361) were correctly diagnosed as non-pregnant during the examined periods of both experiments. [less ▲]

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See detailProstatic androgen repressed message-1 (PARM-1) may play a role in prostatic cell immortalisation.
Cornet, Anne ULg; Hanon, Emmanuel; Reiter, Eric R et al

in Prostate (The) (2003), 56(3), 220-30

BACKGROUND: Prostatic androgen-repressed message-1 (PARM-1) has been cloned from the prostate. The transcript of the PARM-1 gene is overexpressed during regression of the prostate after androgen ... [more ▼]

BACKGROUND: Prostatic androgen-repressed message-1 (PARM-1) has been cloned from the prostate. The transcript of the PARM-1 gene is overexpressed during regression of the prostate after androgen withdrawal. The regulation of PARM-1 by androgens is limited to this organ. We have studied the effects of PARM-1 overexpression in malignant prostate cells. METHODS: The PARM-1 cDNA was introduced into the rat cancer cell line MAT LyLu along with a doxycycline-dependent regulator. RESULTS: Maximal expression of PARM-1 (fivefold induction) was achieved by incubating the cells with 2 microM doxycycline for 48 hr. A study investigating the effect of PARM-1 overexpression on the transcription of 588 genes has shown that the TLP1 gene (encoding rat telomerase protein component 1) was the most up-regulated (fourfold). In addition, a dose-dependent increase in telomerase activity was observed in cells overexpressing PARM-1. In vivo, the androgen-deprived prostate showed an increased TLP1 level and increased telomerase activity. CONCLUSIONS: Increased telomerase activity is often associated with the immortalisation of cancer cell lines, particularly prostatic ones. This could mean that PARM-1 is involved, via increased telomerase activity, in a survival program enabling certain prostatic cells to resist apoptosis, thus conferring a selective advantage to pre-cancerous or cancerous cells. [less ▲]

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See detailThe Mamluk Documents of the Venetian State Archives : Handlist
Bauden, Frédéric ULg

in Quaderni di Studi Arabi (2003), 20-21

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See detailNumerical modelling of metal forming - current practice and advanced applications
Cescotto, Serge ULg; Duchene, Laurent ULg; Pascon, Frédéric ULg et al

in Iu, V. P.; Lamas, L. N.; Li, Y. P. (Eds.) et al Computational Methods in Engineering and Science, lu et al. (eds), Proceedings of the 9th International Conference of enhancement and Promotion of Computing Methods for Engineering and Science (2003)

This paper first summarizes the current possibilities and the perspectives of effective modeling of metal forming processes. Practical considerations on manpower requirement and data availability are ... [more ▼]

This paper first summarizes the current possibilities and the perspectives of effective modeling of metal forming processes. Practical considerations on manpower requirement and data availability are included in the discussion. Then, two examples of advanced applications are presented: the micro-macro approach for the modeling of sheet metal forming and the modeling of continuous casting. [less ▲]

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See detailLe médicament du mois Le voriconazole (Vfend).
Pierard, Gérald ULg; Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2003), 58(5), 351-5

Invasive fungal infections are a rare but important cause of morbidity and mortality among patients with severely compromised host defenses. Despite considerable advances in antifungal therapies over the ... [more ▼]

Invasive fungal infections are a rare but important cause of morbidity and mortality among patients with severely compromised host defenses. Despite considerable advances in antifungal therapies over the past years, invasive mycoses remain a stubborn and dramatic problem. Voriconazole is a new triazole antifungal agent which confers a relative survival benefit in fluconazole-resistant invasive candidiasis, and in invasive aspergillosis, fusariosis and Scedosporium infections as well. [less ▲]

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See detailBelgium's immigration Policy
Martiniello, Marco ULg

in International Migration Review (2003), 37(1), 225-232

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See detailGAIA and the spectroscopic binaries: what to expect in terms of orbit determination?
Pourbaix, D.; Jancart, Sylvie ULg

in GAIA Spectroscopy: Science and Technology (2003)

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See detailSacrifice and Ritualisation of History in Caribbean Drama.
Bada, Valérie ULg

in Glaap, Albert Rainer; Maufort, Marc (Eds.) Keying in to Postcolonial Cultures: Contemporary Plays in English. (2003)

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See detailOn the feeding ecology of the pied kingfisher, Ceryle rudis at Lake Nokoué, Benin. Is there competition with fishermen ?
Laudelout, Arnaud; Libois, Roland ULg

in Cowx I.G. (Ed.) Interactions between fish and birds: implications for management (2003)

Lake Noukoué in southern Benin, is heavily exploited fishery, but it is also inhabited by numerous piscivorous birds, escpecially kingfishers. This study considers the similarity between the diet of ... [more ▼]

Lake Noukoué in southern Benin, is heavily exploited fishery, but it is also inhabited by numerous piscivorous birds, escpecially kingfishers. This study considers the similarity between the diet of kingfishers and fish available on the local market between mid-February to mi-May 1999, durng a low water level preriod. Excretory pellets were collected on the top of breeding banks and inside brood chambers. The diet was determined by comparing the bones recovered from the pellets with a reference collection. Eighteen prey categories were recognised in the 1099 diagnostic items. Kingfishers preyed mostly on cichlids (Sarotherodon melanotheron Rüppell and Hemichromis fasciatus Peters), clupeids (Ethmalosa fimbria (Bowdich)), eleotrids (Kribia sp.) and Hyporhamphus picarti (Val.). Prey size of H. fasciatus ranged from 22 to 73 mm (46.4 +/- 11.6 mm) and S. melanotheron from 24 to 65 mm (44 +/- 9.2 mm). The compositionof the diet varied depending on time and location. Overlap with marketed fish is limitid to S. melanotheron. [less ▲]

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See detailEffets fonctionnels respiratoires induits par l'inhalation de glycopyrrolate chez le cheval poussif en crise
Art, Tatiana ULg; De Moffarts, Brieuc; Van Erck, Emmanuelle et al

in Pratique Vétérinaire Equine (2003), 35(139), 23-29

An acute respiratory attack with bronchospasm is associated with excessive stimulation of the parasympathic nervous system. It may be reduced by administration of anticholinergic agents. Atropine and ... [more ▼]

An acute respiratory attack with bronchospasm is associated with excessive stimulation of the parasympathic nervous system. It may be reduced by administration of anticholinergic agents. Atropine and ipratropium bromide have been tested. This study is to evaluate the efficacy of the synthetic antimuscarinic compound glycopyrrolate as a bronchodilator in horses. Respiratory crisis was induced in seven allergic horses by exposure to natural allergens. Prior to the study, it was established that the attack could be stopped using intravenous atropine sulphate. Pulmonary function tests (ventilation and arterial blood gas analysis) were performed on the horses before and then after aerosol administration of 1500 µg of glycopyrrolate (Robinul®). The attack was characterised by an increase in total pulmonary resis¬tance and maximum pleural pressure variation and by decreased compliance. This study demonstrates that glycopyrrolate exhibits affects that are just as rapid and effective as intravenous atropine or aerosol administration of 1200 µg dry powder Ipratropium. In addi¬tion the treatment was well tolerated and no side-effects were observed in contrast to those seen with intravenous administration of atro¬pine. Therefore this drug has an important role to play among the therapeutics available to practitioners for acute respiratory attacks in horses [less ▲]

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See detailBiomarqueurs de toxicité et anomalies métaboliques dans les principales intoxications graves. Symptomatologie clinique et toxique. Le prélèvement conservatoire.
Goullé, Jean-Pierre; Lhermitte, Michel; Bartholi, M. et al

in Annales de Biologie Clinique (2003), 61

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See detailImprovement of Transport Safety by control of fog production in a chamber
Andre, Philippe ULg

Report (2003)

Rapport final du projet "Improvement of Transport Safety by control of fog production in a chamber", qui s'est déroulé entre 2000 et 2003, finance par l'Union Européenne, dans le cadre du programme ... [more ▼]

Rapport final du projet "Improvement of Transport Safety by control of fog production in a chamber", qui s'est déroulé entre 2000 et 2003, finance par l'Union Européenne, dans le cadre du programme "Growth" [less ▲]

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See detailA review of the major causes of digestive disorders in the European rabbit
Marlier, Didier ULg; Dewrée, Roxane; Delleur, V. et al

in Annales de Médecine Vétérinaire (2003), 147(6, DEC-JAN), 385-392

Digestive diseases frequently occur in rabbitries, inducing high mortality rates and huge economic losses. The major causes of these pathological conditions are described in this review. The current state ... [more ▼]

Digestive diseases frequently occur in rabbitries, inducing high mortality rates and huge economic losses. The major causes of these pathological conditions are described in this review. The current state of knowledge on two diseases of unknown origin, the so called Rabbit Epizootic Enteropathy and Mucoid Enteropathy is also presented. [less ▲]

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