References of "2003"
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See detailDeciphering the impaired cytokine cascades in chronic leg ulcers (review).
Quatresooz, Pascale ULg; Henry, Frédérique ULg; Paquet, Philippe ULg et al

in International Journal of Molecular Medicine (2003), 11(4), 411-8

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis ... [more ▼]

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis. The various cytokines identified in experimental wounds are also present in leg ulcers. VEGF is strongly implicated as a promoter of blood vessel growth in patients with venous disease. In addition, there is good evidence of increased expression of bFGF, TGF-beta1, and PDGF in lipodermatosclerosis. All of these growth factors are involved in wound healing. Upregulated TGF-beta1 is probably one of the main causes of the fibrosis observed in lipodermatosclerosis. In leg ulcers, cytokines appear to be trapped in the perivascular fibrinoid deposits. It is not the nature and amount of cytokines that are inadequate in leg ulcers, but rather their spatial distribution. Dermal dendrocytes (DD) are resident factor XIIIa-enriched macrophages. They likely play a role in tissue repair when boosted adequately. New therapies aiming at helping the release of cytokines by DD apparently promote and improve the healing phase. [less ▲]

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See detailUrticaire de contact suite à l’application d’un fond de teint contenant de l’huile de sésame
Dezfoulian, Bita ULg; de LA BRASSINNE, Michel ULg

in Revue Française d'Allergologie et d'Immunologie Clinique (2003), 43

A number of cosmetic products containing sesame oil are used for daily cutaneous care. The risk of secondary induction of eczema or even anaphylactic shock after topical use of products containing ... [more ▼]

A number of cosmetic products containing sesame oil are used for daily cutaneous care. The risk of secondary induction of eczema or even anaphylactic shock after topical use of products containing vegetable oils is still unknown. We describe the case of 36-years-old atopic, sesame sensitized women who presented with contact urticaria after application of a foundation cream containing sesame oil. Immediate prick and patch tests with sesame oil, sesame grains, the foundation cream and its components confirmed this sensitization. We discuss the innocuousness of vegetable and animal products present in foods and in cosmetics and problems that may occur when they are used by patients during an inflammatory phase of atopic dermatitis and by patients with specific sensitization to these allergens. [less ▲]

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See detailL'iconographie du meurtre de saint Lambert de Liège
George, Philippe ULg

in Bischofsmord im Mittelalter. Murder of Bishops, 22 septembre 2000 (2003)

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See detailL'urticaire et ses implications systémiques
Dezfoulian, Bita ULg; Khalil, Z.; de LA BRASSINNE, Michel ULg

in Revue Médicale de Liège (2003), 58(12), 751-756

Urticaria is a transient eruption of erythematous or oedematous swelling of the dermis and is usually associated with itching which clinically is very easy to diagnose. However, it causes several ... [more ▼]

Urticaria is a transient eruption of erythematous or oedematous swelling of the dermis and is usually associated with itching which clinically is very easy to diagnose. However, it causes several etiological, pathophysiological and therapeutic problems. We will develop the acute and chronic urticaria as well as their different associations with systemic diseases. Some current data concerning chronic idiopathic autoimmune urticaria is reviewed. The management and therapeutics will be discussed. [less ▲]

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See detailJean-Marie Graulich, biographie
Delmer, Andre; Da Silva, Anne-Christine ULg

in Geologica Belgica (2003), 6(3/4), 73-80

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See detailX-Ray spectromicroscopy of clusters heated by fs laser radiation
Faenov, A.Ya.; Magunov, A. I.; Pikuz, T. A. et al

Conference (2003)

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See detailFeeding habits in a dimorphic metapopulation of the tiger salamander Ambystoma tigrinum nebulosum
Denoël, Mathieu ULg; Wissinger, Scott; Whiteman, Howard

Conference (2003)

Facultative paedomorphosis in salamanders refers to the presence of two ontogenetic pathways in natural populations – paedomorphosis, in which individuals retain gills at the adult stage, and ... [more ▼]

Facultative paedomorphosis in salamanders refers to the presence of two ontogenetic pathways in natural populations – paedomorphosis, in which individuals retain gills at the adult stage, and metamorphosis, in which larvae metamorphose. The Mexican Cut Nature Preserve (Colorado, USA) is composed of numerous ponds which are inhabited by paedomorphic and metamorphic tiger salamanders. While paedomorphs usually stay in the same aquatic habitat all their life, metamorphs may leave water and colonize other ponds. The aim of this study was to determine the feeding habits of the two morphs from this metapopulation. To this end, adults were caught by dip-netting, stomach-flushed, measured and marked. Paedomorphs were only found in permanent waters. Metamorphs were present in all habitats, but particularly in the temporary ponds. Diet differed between ponds – reflecting their invertebrate composition – with a preponderance of either microcrustaceans, fairy shrimp or insect larvae. In ponds inhabited by the two morphs, paedomorphs consumed more prey items. Because dry mass and energy content varied between invertebrates, feeding on some of them, such as fairy shrimp in the temporary ponds where they are abundant, gave high energy intake to the predators. Because such resources are only available to the dispersive morph, metamorphs are at the advantage in being able to avoid competition with paedomorphs in permanent ponds and in using transient resources from the productive temporary waters. [less ▲]

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See detailSagriwatel : une vue d'ensemble sur les parcelles.
Tychon, Bernard ULg; Istasse, Alain

Article for general public (2003)

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See detailFloriant et Florete, édition bilingue établie, traduite, présentée et annotée
Combes, Annie ULg; Trachsler, Richard

Book published by Honoré Champion (2003)

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See detailProgramme de cartographie hydrogéologique de la Région wallonne.
Dossin, F.; Bouezmarni, Mohamed ULg; Habils, F. et al

in Eco Karst (2003), (57), 7-10

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See detailAvantages sélectifs d'un phénotype hétérochronique. Eco-éthologie des populations pédomorphiques du Triton alpestre, Triturus alpestris (Amphibia, Caudata)
Denoël, Mathieu ULg

Book published by Cahiers d'Ethologie (2003)

Facultative paedomorphosis is a polyphenism that has important evolutionary implications in promoting morphological differentiation and habitat use variation, and has occurred in several urodele species ... [more ▼]

Facultative paedomorphosis is a polyphenism that has important evolutionary implications in promoting morphological differentiation and habitat use variation, and has occurred in several urodele species throughout the world. Several hypotheses based on life-history theory have been proposed to explain the wide range of habitats where facultative paedomorphosis occurs, suggesting multiple causes. In populations experiencing facultative paedomorphosis, some individuals metamorphose and mature (metamorphs), while others attain sexual maturity while still retaining traits of larval somatic morphology (paedomorphs). The paedomorphic process by which the development of somatic and reproductive organs is shifted between related individuals is assumed to significantly contribute to macro-evolutionary processes. Indeed, it implies large phenotypic variations in the absence of deep genetic changes. A way to explain the importance of these developmental heterochronies is to show their adaptive value in the micro-evolutive stage. The aim of this thesis is to determine the advantages gained by an individual that adopts a paedomorphic developmental pathway rather than a metamorphic one. To do this, we studied five factors: habitat use; resource partitioning; age and size structures; sexual compatibility; and the effect of environmental factors. The ecological and ethological characteristics of several mixed populations (composed of both paedomorphic and metamorphic individuals) of the Alpine newt Triturus alpestris (Amphibia, Salamandridae) were investigated from 1997 to 2000. These populations were located in France, Italy and Greece. The habitats occupied by dimorphic populations of the Alpine newt are highly variable. We have found the two morphs in syntopy in deep permanent lakes, and in small shallow and temporary ponds. Aquatic habitats were surrounded by various terrestrial habitats. As a result, it was not possible to correlate any particular environment type with the maintenance of the polymorphism in natural populations. The only common trait of the paedomorphic populations was that they were located at the southern margin of the range of the species (Italy, the Balkan peninsula, and southeastern France). Such a restriction of the distributional range of paedomorphosis suggests that this trait is maintained by genes which are shared only by these populations. Such a restriction may be due to Holocene colonizations from Pleistocene refugia, in which case paedomorphosis may have appeared in these refugia during the last glaciations. Nevertheless, as long as the phylogeny of the group remains uncertain, we cannot reject the possibility of an earlier origin of paedomorphosis. The two morphs primarily differed in space use and feeding habits. These differences were particularly marked in deep alpine aquatic habitats, where the paedomorphs occupy deep waters devoid of competitors, such as fish. In such waters, the paedomorphs were more abundant on the bottom and in the water column, whereas the metamorphs mainly occupied the water surface and shore. The paedomorphs primarily ingested plankton, while the metamorphs mainly foraged on terrestrial prey that had fallen on the water surface. Although these feeding habits depend on newt habitats - plankton being more abundant in the water column, and terrestrial prey at the water surface - the trophic spectrum in each habitat still differed. While the energetic values of the prey eaten by the two morphs strongly differed, by ingesting a large number of planktonic organisms, the paedomorphs attained similar or even larger caloric intake rates than metamorphs. The paedomorphs' superior body condition suggests that they may have higher long-term success than the metamorphs. Differences in body condition may also reflect the terrestrial life habit of the metamorphs, since metamorphosed individuals are able to avoid competition with reproductive adults and larvae by leaving the water. In the paedomorphic populations, several size-structured cohorts of larvae coexist, and competition among these cohorts is lowered by size-selective predation, since small larvae catch smaller prey than larger larvae and paedomorphs. Although this difference in diet was in part due to gape-size limitation, the gilled individuals also size-selected prey among a range of catchable items. Resource partitioning then favoured the coexistence of the two adult morphs, and their gilled descendants, which coexist with them. The two morphs also differed in feeding performance. Whereas the paedomorphs were better predators than metamorphs on water fleas, metamorphs were more adept at capturing large terrestrial invertebrates (flies). These differences in feeding performances were caused by the morphological particularities of the two morphs. Paedomorphs had a fish-like feeding structure with a unidirectional water flow passing through the oral cavity, and then being expelled through gill slits on the posterior side of the head. In contrast, metamorphs had a smaller oral cavity and a bidirectional water flow due to closed gill slits. Although the metamorphic structure produces less suction, it allows for catching bigger prey because of a larger gape-size (biting rather than sucking). Our measures of feeding performances confirmed the data from natural populations, with each of the morphs preferentially eating their predicted prey. The particular use of micro-habitats by the two morphs is also in agreement with optimality models predicting predation in the more profitable patches. In the Alpine newt, paedomorphosis can be produced by two main processes: neoteny and progenesis. In some populations, the two morphs reached sexual maturity at the same age (neoteny); in other populations, sexual maturity was reached earlier by paedomorphs (progenesis). Progenesis was observed in unstable water habitats. Pond drying suppressed the possibility of late maturation, which is characteristic of a neotenic developmental pathway. On the other hand, the precocious sexual maturation of paedomorphs favoured the fast colonization of new habitats, owing to a high intrinsic rate of natural increase. Neoteny was typical of permanent waters with harsh constraints on growth. By forgoing metamorphosis, larvae also avoid the cost of changing of structure (decrease in body weight in our experiments). Progenetic paedomorphosis appears then as a major trait that can be selected due to the advantages of earlier maturation. The two morphs are sexually compatible; thus, metamorphs can "exchange" genes with paedomorphs at each generation. While the two morphs markedly differ in their secondary sexual characteristics, females did not show any preference related to these characteristics. The absence of sexual isolation between the morphs shows that they are not involved in a sympatric speciation process. The maintenance of the polymorphism is more advantageous than the formation of two isolated species. Paedomorphosis occurs in aquatic habitats where total drying can occur, and where the maintenance of facultative paedomorphosis is maintained by metamorphs that have paedomorphic genes but do not (permanently) express them. In such habitats, the sexual isolation of the two morphs would lead to the extinction of paedomorphosis in the event of pond drying or similar catastrophe. Because the environment can modify the ontogenetic pathway, paedomorphosis in the Alpine newt can be considered a polyphenism. Indeed, restricting the amount of water or food available induces paedomorphs to metamorphose. The marking of individual paedomorphs in a natural population proved that metamorphosis also occurs in the field. However, salamander density and progressive drying of aquaria did not have any apparent effect on paedomorph metamorphosis. When the possibility of a short migration across dry land was given, paedomorphs moved towards an available water basin and maintained their larval somatic characters during the migrations. By being able to migrate on land towards permanent water, paedomorphs are able to retain a feeding morphology that favors them in microhabitats where plankton is abundant. Facultative paedomorphosis in the Alpine newt allows populations to cope with environmental variability, and is adaptive in allowing precocious maturation or a larger use of resources in spatially heterogeneous environments. Thus, it is not surprising that paedomorphosis can evolve in such dissimilar environments as lowland temporary ponds and highland deep lakes. In such places, paedomorphosis appears to be the best solution as long as fish predation is relaxed. The introduction of fish throughout Europe is thus a serious problem, and has resulted in the extinction of several large paedomorphic populations. If this trend is not stopped rapidly, paedomorphosis in the Alpine newt - and in other species - will belong to the past. [less ▲]

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See detailHematopoietic cell transplantation: five decades of progress.
Baron, Frédéric ULg; Storb, Rainer; Little, Marie-Terese

in Archives of Medical Research (2003), 34(6), 528-44

During the past 50 years, the role of allogeneic hematopoietic cell transplantation (HCT) has changed from a desperate therapeutic maneuver plagued by apparently insurmountable complications to a curative ... [more ▼]

During the past 50 years, the role of allogeneic hematopoietic cell transplantation (HCT) has changed from a desperate therapeutic maneuver plagued by apparently insurmountable complications to a curative treatment modality for thousands of patients with hematologic diseases. Now, cure rates following human leukocyte antigen (HLA) allogeneic HCT with matched siblings exceed 85% for some otherwise lethal diseases, such as chronic myeloid leukemia, aplastic anemia, or thalassemia. In addition, the recent development of non-myeloablative conditioning and stem cell transplantation has opened the way to include elderly patients with a wide variety of hematologic malignancies. Further progress in adoptive transfer of T cell populations with relative tumor specificity would make the transplant procedure more effective and would extend the use of allogeneic HCT for treatment of non-hematopoietic malignancies. [less ▲]

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See detailFrançois Schuiten, créateur sans frontière
Dejasse, Erwin ULg

Article for general public (2003)

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See detailWavelet denoising of Poisson-distributed data and applications.
Charles, Catherine ULg; Rasson, Jean-Paul

in Computational Statistics & Data Analysis (2003), 43

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See detailStability analysis of Bénard-Marangoni convection in the case of cooling from below
Dondlinger, Mireille; Dauby, Pierre ULg

in Proceedings du 6ème Congrès National de Mécanique théorique et appliquée (NCTAM-2003), Gent (Belgium), 26-27 may 2003 (2003)

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See detailDes statines pour le cerveau?
Sadzot, Bernard ULg; HANS, Grégory ULg; Bottin, P. et al

in Revue Médicale de Liège (2003), 58(10), 621-7

Whether cholesterol lowering decreases risk of stroke has long remained unclear. Large epidemiological studies have found only weak links between cholesterol levels and stroke. Recent studies with statins ... [more ▼]

Whether cholesterol lowering decreases risk of stroke has long remained unclear. Large epidemiological studies have found only weak links between cholesterol levels and stroke. Recent studies with statins, more potent cholesterol lowering agents, have now demonstrated significant reductions of stroke incidence and total mortality when administered for secondary prevention in patients with wide ranges of cholesterol values. It remains unknown if a statin is superior to others for the secondary prevention of stroke. [less ▲]

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See detailInositol 1,3,4,5-tetrakisphosphate is essential for normal T lymphocyte development
Pouillon, V.; Hascakova-Bartova, R.; Pajak, B. et al

in Nature Immunology (2003), 4

Inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) is phosphorylated by Ins(1,4,5)P(3) 3-kinase, generating inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P(4)). The physiological function of Ins(1,3,4,5)P(4 ... [more ▼]

Inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) is phosphorylated by Ins(1,4,5)P(3) 3-kinase, generating inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P(4)). The physiological function of Ins(1,3,4,5)P(4) is still unclear, but it has been reported to be a potential modulator of calcium mobilization. Disruption of the gene encoding the ubiquitously expressed Ins(1,4,5)P(3) 3-kinase isoform B (Itpkb) in mice caused a severe T cell deficiency due to major alterations in thymocyte responsiveness and selection. However, we were unable to detect substantial defects in Ins(1,4,5)P(3) amounts or calcium mobilization in Itpkb(-/-) thymocytes. These data indicate that Itpkb and Ins(1,3,4,5)P(4) define an essential signaling pathway for T cell precursor responsiveness and development [less ▲]

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See detailPortrait of the Prose Poet as Glutton
Delville, Michel ULg

in Sentence: A Journal of Prose Poetics (2003)

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