References of "2003"
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See detailHistological study of immature interspecific embryo abortion between Phaseolus vulgaris L. and P. polyanthus Greenm.
Toussaint, André ULg; Geerts, P.; Mergeai, Guy ULg et al

in Annual Report of the Bean Improvment Cooperative (2003), 46

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See detailNF-κB transcription factor induces drug resistance through MDR1 expression in cancer cells
Bentires-Alj, Mohamed; Barbu, Véronique; Fillet, Marianne ULg et al

in Oncogene (2003), 22

The ubiquitous NF-kappaB transcription factor has been reported to inhibit apoptosis and to induce drug resistance in cancer cells. Drug resistance is the major reason for cancer therapy failure and ... [more ▼]

The ubiquitous NF-kappaB transcription factor has been reported to inhibit apoptosis and to induce drug resistance in cancer cells. Drug resistance is the major reason for cancer therapy failure and neoplastic cells often develop multiple mechanisms of drug resistance during tumor progression. We observed that NF-kappaB or P-glycoprotein inhibition in the HCT15 colon cancer cells led to increased apoptotic cell death in response to daunomycin treatment. Interestingly, NF-kappaB inhibition through transfection of a plasmid coding for a mutated IkappaB-alpha inhibitor increased daunomycin cell uptake. Indeed, the inhibition of NF-kappaB reduced mdr1 mRNA and P-glycoprotein expression in HCT15 cells. We identified a consensus NF-kappaB binding site in the first intron of the human mdr1 gene and demonstrated that NF-kappaB complexes could bind with this intronic site. Moreover, NF-kappaB transactivates an mdr1 promoter luciferase construct. Our data thus demonstrate a role for NF-kappaB in the regulation of the mdr1 gene expression in cancer cells and in drug resistance. [less ▲]

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See detailÉlaboration d'une base de données en vue de l'informatisation du catalogue de la cartothèque de l'Unité de documentation des Sciences de la Terre de l'Université de Liège
Borsus, Olivier ULg

Master's dissertation (2003)

Ce mémoire est destiné à l'Unité de Documentation (U.D.) des Sciences de la Terre de l'Université de Liège et consiste en l'élaboration d'une base de données pour le catalogue de son fonds cartographique ... [more ▼]

Ce mémoire est destiné à l'Unité de Documentation (U.D.) des Sciences de la Terre de l'Université de Liège et consiste en l'élaboration d'une base de données pour le catalogue de son fonds cartographique. En effet, l'interface LIBER utilisée à l'Université ne répond pas entièrement aux attentes de l'U.D en terme de critères de recherche spécifiques aux documents cartographiques. Par conséquent il était nécessaire de réaliser une interface conviviale et pratique pour la recherche et la saisie des références de ces cartes. Le logiciel utilisé est FileMaker Pro 5. Pour faciliter l'utilisation de cette base de données, un thésaurus reprenant tous les pays du monde a été créé. A cette fin, les difficultés dues aux changements de noms régionaux et nationaux résultant des évolutions historiques et politiques au fil du temps ont fait l'objet d'une attention particulière. [less ▲]

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See detailOrigine et impact des risques biologiques, physiques et chimiques
Samb, Babacar; Schiffers, Bruno ULg

in Proceedings Bio-Scope - Atelier "Responsable Assurance Qualité Totale" (2003)

La préservation de la santé des consommateurs est devenue une préoccupation majeure en ce début de nouveau millénaire marqué par le poids de la société civile en général et des ligues de consommateurs en ... [more ▼]

La préservation de la santé des consommateurs est devenue une préoccupation majeure en ce début de nouveau millénaire marqué par le poids de la société civile en général et des ligues de consommateurs en particulier. Les exigences en termes de qualité sanitaire et de traçabilité, qui figurent non seulement dans des réglementations toujours plus strictes mais aussi dans des référentiels de qualité ou des cahiers de charge imposés aux producteurs, traduisent la volonté des consommateurs européens de savoir où, comment et quand les aliments qu'ils ont dans leur assiette ont été produits. [less ▲]

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See detailDeciphering the impaired cytokine cascades in chronic leg ulcers (review).
Quatresooz, Pascale ULg; Henry, Frédérique ULg; Paquet, Philippe ULg et al

in International Journal of Molecular Medicine (2003), 11(4), 411-8

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis ... [more ▼]

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis. The various cytokines identified in experimental wounds are also present in leg ulcers. VEGF is strongly implicated as a promoter of blood vessel growth in patients with venous disease. In addition, there is good evidence of increased expression of bFGF, TGF-beta1, and PDGF in lipodermatosclerosis. All of these growth factors are involved in wound healing. Upregulated TGF-beta1 is probably one of the main causes of the fibrosis observed in lipodermatosclerosis. In leg ulcers, cytokines appear to be trapped in the perivascular fibrinoid deposits. It is not the nature and amount of cytokines that are inadequate in leg ulcers, but rather their spatial distribution. Dermal dendrocytes (DD) are resident factor XIIIa-enriched macrophages. They likely play a role in tissue repair when boosted adequately. New therapies aiming at helping the release of cytokines by DD apparently promote and improve the healing phase. [less ▲]

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See detailAmphiphilic copolymers of epsilon-caprolactone and gamma-substituted epsilon-caprolactone. Synthesis and functionalization of poly(D,L-lactide) nanoparticles
Gautier, Sandrine; D'Aloia, Violetta; Halleux, Olivier et al

in Journal of Biomaterials Science. Polymer Edition (2003), 14(1), 63-85

Fully biodegradable and surface-functionalized poly(D,L-lactide) (PLA) nanoparticles have been prepared by a co-precipitation technique. Novel amphiphilic random copolyesters P(CL-co-gamma XCL) were ... [more ▼]

Fully biodegradable and surface-functionalized poly(D,L-lactide) (PLA) nanoparticles have been prepared by a co-precipitation technique. Novel amphiphilic random copolyesters P(CL-co-gamma XCL) were synthesized by controlled copolymerization of epsilon-caprolactone and epsilon-caprolactone substituted in the gamma-position by a hydrophilic X group, where X is either a cationic pyridinium (gamma-Py-CL) or a non-ionic hydroxyl (gamma-OH-CL). Nanoparticles were prepared by co-precipitation of PLA with the P(CL-co-gamma-XCL) copolyester from a DMSO solution. Small amounts of cationic P(CL-co-gamma-Py-CL) copolymers are needed to quantitatively form stable nanoparticles (ca. 10 mg/100 mg PLA), although larger amounts of non-ionic P(CL-co-gamma-OH-CL) copolymers are needed (ges12.5 mg/100 mg PLA). Copolymers with a low degree of polymerization (ca. 40) are more efficient stabilizers, probably because of faster migration towards the nanoparticle-water interface. The nanoparticle diameter decreases with the polymer concentration in DMSO, e.g. from ca. 160 nm (16 mg/ml) to ca. 100 nm (2 mg/ml) for PLA/P(CL-co-gamma-Py-CL) nanoparticles. Migration of the P(CL-co-gamma-XCL) copolyesters to the nanoparticle surface was confirmed by measurement of the zeta potential, i.e. ca. +65 mV for P(CL-co-gamma-Py-CL) and -7 mV for P(CL-co-gamma-OH-CL). The polyamphiphilic copolyesters stabilize PLA nanoparticles by electrostatic or steric repulsions, depending on whether they are charged or not. They also impart functionality and reactivity to the surface, which opens up new opportunities for labelling and targeting purposes. [less ▲]

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See detailBiomarqueurs de toxicité et anomalies métaboliques dans les principales intoxications graves. Symptomatologie clinique et toxique. Le prélèvement conservatoire.
Goullé, Jean-Pierre; Lhermitte, Michel; Bartholi, M. et al

in Annales de Biologie Clinique (2003), 61

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See detailUsing on-site observations for low back related work load assessment - Methodological issues
Somville, Pierre-René ULg; Mairiaux, Philippe ULg

in Strasser, H.; Kluth, K.; Rausch, H. (Eds.) et al Quality of work and products in enterprises of the future (2003)

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See detailArterial embolization as a treatment of chronic edema following free cutaneous flap transfer to the lower limbs.
Tchuisse, Charlemagne Noukoua; Barah, Ali; NCHIMI LONGANG, Alain ULg et al

in Cardiovascular & Interventional Radiology (2003), 26(3), 316-8

Persisting chronic edema following postoperative free flap transfer is a common complication. We report 3 cases of successful treatment by selective arterial embolization of the feeding arterial branches ... [more ▼]

Persisting chronic edema following postoperative free flap transfer is a common complication. We report 3 cases of successful treatment by selective arterial embolization of the feeding arterial branches without side effect. One session embolization is advocated as a first line treatment of this condition. [less ▲]

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See detailThe role of reactive oxygen species in homeostasis and degradation of cartilage.
Henrotin, Yves ULg; Bruckner, P.; Pujol, J. P.

in Osteoarthritis and Cartilage (2003), 11(10), 747-55

OBJECTIVES: The metabolism of cells in articular joint tissues in normal and pathological conditions is subject to a complex environmental control. In addition to soluble mediators such as cytokines and ... [more ▼]

OBJECTIVES: The metabolism of cells in articular joint tissues in normal and pathological conditions is subject to a complex environmental control. In addition to soluble mediators such as cytokines and growth factors, as well as mechanical stimuli, reactive oxygen species (ROS) emerge as major factors in this regulation. ROS production has been found to increase in joint diseases, such as osteoarthritis and rheumatoid arthritis, but their role in joint diseases initiation and progression remains questionable. METHOD: This review is focused on the role of ROS, mainly nitric oxide, peroxynitrite and superoxide anion radicals, in the signaling mechanisms implied in the main cellular functions, including synthesis and degradation of matrix components. The direct effects of ROS on cartilage matrix components as well as their inflammatory and immunomodulatory effects are also considered. RESULTS: Some intracellular signaling pathways are redox sensitive and ROS are involved in the regulation of the production of some biochemical factors involved in cartilage degradation and joint inflammation. Further, ROS may cause damage to all matrix components, either by a direct attack or indirectly by reducing matrix components synthesis, by inducing apoptosis or by activating latent metalloproteinases. Finally, we have highlighted the uncoupling effect of ROS on tissue remodeling and synovium inflammation, suggesting that antioxidant therapy could be helpful to treat structural changes but not to relieve symptoms. CONCLUSIONS: This review of the literature supports the concept that ROS are not only deleterious agents involved in cartilage degradation, but that they also act as integral factors of intracellular signaling mechanisms. Further investigation is required to support the concept of antioxidant therapy in the management of joint diseases. [less ▲]

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See detailLa formation continue en Belgique : profils des participants et esquisses de parcours : exploitation de l'Enquête sur les Forces de Travail 2000
Baye, Ariane ULg; Mainguet, Christine ULg; Demeuse, Marc ULg et al

in Guyot, J. (Ed.) La formation professionnelle continue : l'individu au coeur des dispositifs (2003)

La diffusion de la notion de 'formation tout au long de la vie' dans les discours politiques amène à un renouvellement des interrogations sur la formation continue des adultes. Les outils de mesure se ... [more ▼]

La diffusion de la notion de 'formation tout au long de la vie' dans les discours politiques amène à un renouvellement des interrogations sur la formation continue des adultes. Les outils de mesure se sont progressivement adaptés à cette nouvelle donne; c'est le cas de l'Enquête sur les Forces de Travail (EFT) d'Eurostat mise en oeuvre en Belgique par l'INS. Grâce à l'exploitation inédite de certaines variables de l'enquête, nous avons voulu approcher les dynamiques individuelles qui sous-tendent la participation à diverses formes de formation continue. Ces dynamiques peuvent en effet être abordées sous l'angle de l'accès, de l'investissement en temps et des objectifs poursuivis par les personnes, mais également par le biais des résultats obtenus, par exemple, en termes d'amélioration du niveau de qualification. En amont et en aval du processus de formation, motivations initiales et situations sur le marché du travail peuvent aussi permettre de mieux cerner le fonctionnement de la formation continue. [less ▲]

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See detailEffect of hemicellulase preparations on performance parameters, intestinal viscosity and apparent nutrient digestibility of male broilers fed a wheat-based diet
Vandeplas, Sabrina ULg; Beckers, Yves ULg; Thewis, André ULg

Poster (2003)

Three experiments were conducted to investigate the mode of action of 5 hemicellulases supplemented to wheat-based broiler diets. Performances parameters and digesta viscosity were measured during growth ... [more ▼]

Three experiments were conducted to investigate the mode of action of 5 hemicellulases supplemented to wheat-based broiler diets. Performances parameters and digesta viscosity were measured during growth period. Total collection of excreta was carried out for determination of AMEn content of the diets and of apparent crude fat, Kjeldahl-nitrogen and crude cellulose digestibilities. Addition of xylanase improve daily body gain by 1 to 6% and feed conversion ration by 1,5 to 4%, as the apparent nutrient digestibility and the content of AMEn in the diets supplemented with enzymes. Although viscosity values seemed not correled to improved performances, Grindazym G shows an increase in the digesta viscosity for all the period of measurement. It can be concluded that the beneficial action of xylanases is more due to the improved release of the nutrients entrapped by the NSP, following degradation of these structures, than to the generally accepted decrease in digesta viscosity. [less ▲]

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See detailClinching joining system: validation of numerical models
Pietrapertosa, C.; Zhang, Lihong ULg; Habraken, Anne ULg et al

in Brucato, V. (Ed.) Proceedings of the 6th International ESAFORM Conference on Material Forming (2003)

The clinching process, also known as “press joining”, is a mechanical joining technique for sheet metal. Its basic principle is to clamp together several metal sheets by an impact extrusion between a ... [more ▼]

The clinching process, also known as “press joining”, is a mechanical joining technique for sheet metal. Its basic principle is to clamp together several metal sheets by an impact extrusion between a punch and a die. The joint is formed by a localized cold plastic deformation. Forming is used as a joining method. Within the context of this research, University of Liège is developing numerical models, with the FEM code LAGAMINE, that simulate the clinching process. On the other hand, shear tests on simple joints with one or two clinches were realized and their behaviour is reproduced numerically with LAGAMINE. This work opens the way to the analytical formulation of the behaviour of clinched joints. The article will focus on comparisons between experiments and numerical simulations. First, the identification of model parameters will be explained. Then, the predicted failure modes will be analysed by comparison with the xperiments. [less ▲]

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See detailAnalyses technologiques d’un atelier de taille aurignacien à Maisières-Canal (Province du Hainaut, Belgique)
Miller, Rebecca ULg; Flas, Damien ULg; Guillaume, Alain et al

in Notae Praehistoricae (2003), 23

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See detailLa filière "céréales"
Gobillon, L.; Lebailly, Philippe ULg

Diverse speeche and writing (2003)

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See detailOn Iterating Linear Transformations over Recognizable Sets of Integers
Boigelot, Bernard ULg

in Theoretical Computer Science (2003), 309(1-3), 413-468

It has been known for a long time that the sets of integer vectors that are recognizable by finite-state automata are those that can be defined in an extension of Presburger arithmetic. In this paper, we ... [more ▼]

It has been known for a long time that the sets of integer vectors that are recognizable by finite-state automata are those that can be defined in an extension of Presburger arithmetic. In this paper, we address the problem of deciding whether the closure of a linear transformation preserves the recognizable nature of sets of integer vectors. We solve this problem by introducing an original extension of the concept of recognizability to sets of vectors with complex components. This generalization allows to obtain a simple necessary and sufficient condition over linear transformations, in terms of the eigenvalues of the transformation matrix. We then show that these eigenvalues do not need to be computed explicitly in order to evaluate the condition, and we give a full decision procedure based on simple integer arithmetic. The proof of this result is constructive, and can be turned into an algorithm for applying the closure of a linear transformation that satisfies the condition to a finite-state representation of a set. Finally, we show that the necessary and sufficient condition that we have obtained can straightforwardly be turned into a sufficient condition for linear transformations with linear guards. [less ▲]

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See detailEinstein oscillators in thallium filled antimony skutterudites
Hermann, Raphaël ULg; Jin, R. J.; Schweika, W. et al

in Physical Review Letters (2003), 90(13),

Inelastic neutron scattering measurements on several Tl filled skutterudites (Tl0.5Co3.5Fe0.5Sb12, Tl0.8Co3FeSb12, and Tl0.8Co4Sb11Sn) all show a sharp peak in the vibrational density of states at 57 ... [more ▼]

Inelastic neutron scattering measurements on several Tl filled skutterudites (Tl0.5Co3.5Fe0.5Sb12, Tl0.8Co3FeSb12, and Tl0.8Co4Sb11Sn) all show a sharp peak in the vibrational density of states at 57 +/- 2 K, which is absent in the unfilled skutterudite CoSb3. Heat capacity measurements on Tl0.8Co4Sb11Sn as compared to CoSb3 are consistent with the presence of a localized vibrational mode associated with the "rattling" thallium atoms in this filled skutterudite compound. Both results are well described by a localized Einstein mode model with an Einstein temperature Theta(E) of 53 +/- 1 K. These data provide perhaps the clearest example of local mode behavior in a concentrated metallic system. [less ▲]

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See detailPhysical processes study in the transition zone of the Northwest African upwelling: climatological data analysis
Elmoussaoui, Abdellali; Djenidi, Salim ULg; Kostianoy, Andrey

(2003)

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See detailPara-Adrenal Adrenal Pseudocyst
Milicevic, Mladen ULg; Dondelinger, Robert ULg; Detry, Olivier ULg

in JBR-BTR : Journal Belge de Radiologie - Belgisch Tijdschrift voor Radiologie (2003), 86(3, May-Jun), 166-7

Detailed reference viewed: 36 (5 ULg)