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See detailRadiothérapie externe accélérée postopératoire des carcinomes épidermoïdes localement évolués de la sphère ORL : étude prospective de phase II
Zouhair, A; COUCKE, Philippe ULg; Azria, D. et al

in Bulletin du Cancer. Radiothérapie : Journal de la Société Française du Cancer : Organe de la Société Française de Radiothérapie Oncologique (2003), 7

Abstract Purpose. – To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). Patients and methods ... [more ▼]

Abstract Purpose. – To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). Patients and methods. – Between December 1997 and July 2001, 68 patients (male to female ratio: 52/16; median age: 60-years (range: 43–81) with pT1-pT4 and/or pN0-pN3 SCCHN (24 oropharynx, 19 oral cavity, 13 hypopharynx, 5 larynx, 3 unknown primary, 2 maxillary sinus, and 2 salivary gland) were included in this prospective study. Postoperative RT was indicated because extracapsular infiltration (ECI) * Auteur correspondant. Adresse e-mail : abderrahim.zouhair@chuv.hospvd.ch (A. Zouhair). Cancer/Radiothérapie 7 (2003) 231–236 www.elsevier.com/locate/canrad © 2003 Éditions scientifiques et médicales Elsevier SAS. Tous droits réservés. doi:10.1016/S1278-3218(03)00041-6 was observed in 20 (29%), positive surgical margins (PSM) in 20 (29%) or both in 23 patients (34%). Treatment consisted of external beam RT 66 Gy in 5 weeks and 3 days. Median follow-up was 15 months. Results. – According to CTC 2.0, acute morbidity was acceptable: grade 3 mucositis was observed in 15 (22%) patients, grade 3 dysphagia in 19 (28%) patients, grade 3 skin erythema in 21 (31%) patients with a median weight loss of 3.1 kg (range: 0–16). No grade 4 toxicity was observed. Median time to relapse was 13 months; we observed only three (4%) local and four (6%) regional relapses, whereas eight (12%) patients developed distant metastases without any evidence of locoregional recurrence. The 2 years overall-, disease-free survival, and actuarial locoregional control rates were 85, 73 and 83% respectively. Conclusion. – The reduction of the overall treatment time using postoperative accelerated RT with weekly concomitant boost (six fractions per week) is feasible with local control rates comparable to that of published data. Acute RT-related morbidity is acceptable. [less ▲]

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See detailBiomarkers useful in toxicology
Charlier, Corinne ULg

Conference (2003)

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See detailEffets fonctionnels respiratoires induits par l'inhalation de glycopyrrolate chez le cheval poussif en crise
Art, Tatiana ULg; de Moffarts, Brieuc; Van Erck, Emmanuelle et al

in Annales de Médecine Vétérinaire (2003), 147

Bronchoconstriction is one of the most constant clinical sign observed in heaves-affected horses in crisis. Cholinergic pathways are involved in the occurrence of this obstruction. Consequently ... [more ▼]

Bronchoconstriction is one of the most constant clinical sign observed in heaves-affected horses in crisis. Cholinergic pathways are involved in the occurrence of this obstruction. Consequently anticholinergic drugs are potentially able to improve the pulmonary function of horses in acute crisis. Among these, atropine and ipratropium bromide have been previously experimented and their beneficial effects reported. In the present work, glycopyrrolate, another synthetic anticholinergic molecule has been tested for bronchodilator efficiency in heaves-affected horses. An acute exacerbation of the illness was obtained by a natural challenge with hay and straw in 7 heaves-affected horses. The first day, the reversibility of the bronchospasm of these horses was controlled by intravenous administration of atropine. Then, pulmonary function tests including mechanics of breathing, ie measurement of pleural pressure changes and respiratory airflows, and arterial blond gases analysis, were performed before as well as 15 and 60 minutes alter inhalation of 1500 µg of glycopyrrolate (Robinul®). The crisis induced a dramatic increase of total pulmonary resistance and maximal pleural pressure changes as well as a decrease in dynamic lung compliance. These changes were significantly reversed 15 and 60 minutes after inhalation of glycopyrrolate. We did not observe any adverse effects similar to those classically observed with atropine. These results showed that glycopyrrolate is a very efficient bronchodilator that may be used by the practitioner to treat a heaves-affected horses in crisis [less ▲]

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See detailContribution à la mise au point d'une méthode de lutte biologique contre la maladie des pourritures de la couronne de la banane
Lassois, Ludivine ULg

Master's dissertation (2003)

The antagonist activity of two yeast strains (Pichia anomala K strain and Candida oleophila O strain) against the parasitic complex responsible for crowns rot of banana has been evaluated. Their ... [more ▼]

The antagonist activity of two yeast strains (Pichia anomala K strain and Candida oleophila O strain) against the parasitic complex responsible for crowns rot of banana has been evaluated. Their efficiency has been tested on three separated fungi : Colletotrichum musae, Fusarium moiliforme, Cephalosporium sp. and on a parasitic complex formed by the association of these three fungi. Antagonist effects have been observed both on the two first fungi and on the complex. Strain O added at 108 ufc/ml on crowns which were previously inoculated with the complex showed the highest protection (56,0 %). This protection was superior to those observed against the fungi inoculated separately. The influence of the time between the addition of the O strain (108 ufc/ml) and the inoculation of the pathogens on the level of protection has also been measured. It appeared that protection by the O strain was remarkably reinforced when the strain was added 24 hours before the complex (57,0 %). This, in comparison with the additions performed 15 minutes or 3 hours after the pathogens inoculation. The utilisation of the O strain at 108 ufc/ml has been combined with the utilisation of 50μm polybags. These latter allow the formation of a modified atmosphere during the length of the bunches transfer. The protection level was at 61,0% when both methods were combined whereas protection by the yeast alone was of 41,0%. A strict correlation between the severity of the symptoms and the protection by the yeast has been highlighted. When the severity of the disease increases, protection by the yeast decreases. [less ▲]

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See detailProjet FIRST Europe Ojectif 1 (OLIPOL-Synthèse de nouveaux (co)-polymères d'origine végétale par voie catalytique) Rapport III
Richel, Aurore ULg

Report (2003)

Le principal objectif visé par le présent travail est de mettre au point des catayseurs efficaces, capables de polymériser par voir radicalaire contrôlée des oléfines internes (peu réactionnelles) et ... [more ▼]

Le principal objectif visé par le présent travail est de mettre au point des catayseurs efficaces, capables de polymériser par voir radicalaire contrôlée des oléfines internes (peu réactionnelles) et, plus particulièrement, l'huile de lin.Nous tenterons aussi d'aborder la copolymérisation de l'huile de lin avec des monomères de grande consommation (styrène et (méth)acrylates) afin de mettre au point, au départ d'un produit naturel et renouvelable, des matériaux nouveaux. L'huile de lin est constituée d'un mélange complexe de triglycérides dont les chaînes pendantes sont porteuses de 2 ou 3 liaisons C=C doubles. Face à la diversité et à la complexité structurale de ces molécules, il nous parait évident d'aborder le problème de manière plus systématique en nous basant sur l'étude de la polymérisation d'oléfines internes et/ou fonctionnalisées qui serviront de "modèles" pour celles rencontrées dans l'huile de lin. Nous sommes en effet convaincus que la réussite de ce projet passe avant tout par une bonne compréhension des facteurs qui gouvernent la réactivité des oléfines internes et fonctionnalisées. Ce projet est réalisé dans le Laboratoire de Chimie Macromoléculaire et de Catalyse Organique (CERM) de l'Université de Liège en partenariat avec l'Institut des Sciences de Matériaux (ICMAB, Barcelone) et la Société Vandeputte (Belgique [less ▲]

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See detailA randomized study over 13 cycles to assess the influence of oral contraceptives containing ethinylestradiol combined with drospirenone or desogestrel on carbohydrate metabolism.
Gaspard, Ulysse ULg; Scheen, André ULg; Endrikat, J. et al

in Contraception (2003), 67(6), 423-9

In this open-label, randomized study we compared the influence of a new oral contraceptive containing 30 microg ethinylestradiol and 3 mg drospirenone (Yasmin) with a reference preparation containing 30 ... [more ▼]

In this open-label, randomized study we compared the influence of a new oral contraceptive containing 30 microg ethinylestradiol and 3 mg drospirenone (Yasmin) with a reference preparation containing 30 microg ethinylestradiol and 150 microg desogestrel (Marvelon) on variables of carbohydrate metabolism by means of oral glucose tolerance tests at baseline and in the 6th and 13th treatment cycle. The mean levels of fasting glucose and insulin were similar at baseline and after 13 treatment cycles, whereas C-peptide and free fatty acid levels decreased slightly in both groups. All blood glucose and insulin values measured in the oral glucose tolerance tests were within normal ranges, despite a slight increase in the mean areas under the curves of 0-3 h [AUCs (0-3 h)] of both variables from baseline to treatment cycle 13. Differences between both treatments were not statistically significant. The mean AUCs (0-3 h) for C-peptide were not markedly changed in any treatment group. Free fatty acid levels decreased by 42% in the drospirenone group and increased by 48.9% in the desogestrel group, in terms of means of individual changes. Both preparations were well tolerated and equally efficacious regarding contraception and cycle control. The mean body weight was slightly decreased in most cycles during treatment with the drospirenone combination, as compared to baseline, while it was slightly increased versus baseline in all cycles during treatment with the desogestrel combination. The combination with drospirenone had less impact on blood pressure than the combination with desogestrel. In conclusion, Yasmin, a combined low-dose oral contraceptive with 30 microg ethinylestradiol and 3 mg of the novel progestogen drospirenone, as well as the reference Marvelon, containing 30 microg ethinylestradiol and 150 microg desogestrel had little impact on carbohydrate metabolism when used for 1 year. The observed changes were small and not suggestive of a clinically relevant deterioration of carbohydrate metabolism. [less ▲]

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See detailValidating structural models in non-linear dynamics
Kerschen, Gaëtan ULg; Golinval, Jean-Claude ULg

in 6ème congrès national de Mécanique Th. et App., Gent, 2003 (2003)

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See detailVerso il coordinamento : formazione e innovazione nella Comunità francese del Belgio
Pirard, Florence ULg

in Musatti, T.; Mayer, S. (Eds.) Il coordinamento dei servizi educativi per l’infanzia. Una funzione emergente in Italia e in Europa (2003)

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See detailANGULAR DEPENDENT VORTEX DYNAMICS IN SUPERCONDUCTORS WITH COLUMNAR DEFECTS
Civale, L.; Silhanek, Alejandro ULg; Pasquini, G.

in Narlikar, Anant (Ed.) Irradiation effects and cationinc disorder in HTS (2003)

This book chapter described the vortex pinning properties of type II superconductors with columnar defects by means of magnetization and ac-susceptibility measurements.

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See detailHaplotype sharing refines the location of an imprinted quantitative trait locus with major effect on muscle mass to a 250-kb chromosome segment containing the porcine IGF2 gene
Nezer, C.; Collette, C.; Moreau, L. et al

in Genetics (2003), 165(1), 277-285

We herein describe the fine mapping of an imprinted QTL with major effect on muscle mass that was previously assigned to distal SSC2p in the pig. The proposed approach exploits linkage disequilibrium in ... [more ▼]

We herein describe the fine mapping of an imprinted QTL with major effect on muscle mass that was previously assigned to distal SSC2p in the pig. The proposed approach exploits linkage disequilibrium in combination with QTL genotyping by marker-assisted segregation analysis. By identifying a haplotype shared by all "Q" chromosomes, we map the QTL to an approximately 250-kb chromosome segment containing INS and IGF2 as the only known paternally expressed genes. This considerably reinforces the candidacy of these genes, justifying their detailed analysis. [less ▲]

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See detailLe lérot: trois études en une enquête
Libois, Roland ULg

Learning material (2003)

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See detailStudy of the cap-like gene of Streptomyces coelicolor
Derouaux, Adeline ULg; Titgemeyrer, Fritz; Dusart, Jean et al

Poster (2003)

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See detailA stepwise approach for chemical risks assessment at the workplace
Mairiaux, Philippe ULg; Balsat, Alain; Dujardin, Marco et al

Scientific journal (2003)

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See detailHistomycologie unguéale
Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg; Franchimont, Claudine ULg et al

in Annales de Dermatologie et de Vénéréologie (2003), 130

The diversity of onychomycoses is large when the disease is scrutinized using traditional, fluorescence or confocal microscopy. Histomycology is a non-invasive assessment performed on nail clippings. The ... [more ▼]

The diversity of onychomycoses is large when the disease is scrutinized using traditional, fluorescence or confocal microscopy. Histomycology is a non-invasive assessment performed on nail clippings. The location of and the density in fungal cells is variable. In some instances, these aspects remain clinically unsuspected. In vivo confocal microscopy can bring the same information. Computerized image analysis of histological sections is the most performant means for quantifying the fungal load. Immunohistochemistry brings information about the identity of the fungus or the association of different fungi present in the nail plate. Mixed infections may be unifocal or located at different levels in the nail apparatus. The viability of fungi as assessed by vital stains can be assessed under the microscope and quantified by flow cytometry. The different facets of nail histomycology are complementary and shed some light on aspects sometimes unsuspected of onychomycoses. [less ▲]

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See detailMonitoring the odour of compost as a process variable
Romain, Anne-Claude ULg; Kuske, M.; Nicolas, Jacques ULg

in Kleperis, janis (Ed.) book of abstracts of the 10th international symposium on olfaction and electronic nose (2003)

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See detailLe Livre de Margery Kempe: plume d'homme, voix de femme
Dor, Juliette ULg

in Stévanovitch, Colette; Tixier, René (Eds.) Mélanges offerts à Guy Bourquin à l'occasion de son 75ème anniversaire (2003)

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See detailTowards a more versatile alpha-glucan biosynthesis in plants
Jacon, Géraldine ULg

in Journal of Plant Physiology (2003)

During the last 10 years, the increased need for starches with novel properties has occupied the research community, and many efforts were concentrated on unraveling the starch bio- synthesis pathways ... [more ▼]

During the last 10 years, the increased need for starches with novel properties has occupied the research community, and many efforts were concentrated on unraveling the starch bio- synthesis pathways. The knowledge generated in these investigations was subsequently used to produce tailor-made starches in higher plants using recombinant DNA technology. Examples of starches with new functionalities are those with a modified degree of branching (Schwall et al. 2000, Shewma- ker et al. 1994, Kortstee et al. 1996) and the amylose-free starch (Visser et al. 1991a, Kuipers et al.1994), some of which hold potential for applications in the paper-, textile-, plastics-, food and pharmaceutical industry. The accumulation of more starch has also been an objective, but this will not be dis- cussed further here, (see: Slattery et al. 2000). In our laboratory, we have embarked on two generic tech- nologies with a very wide range of applicability: (i) introduction of new linkages types and structural elements using glu- cansucrases, and (ii) engineering granule-boundness by using microbial starch-binding domains (SBDs). It is expected that these technologies will contribute substantially to the biosynthesis of more versatile α-glucans in the near future, leading to starches with altered functionalities that cannot be obtained by conventional breeding. In this study recent developments in starch modification using heterologous expression of microbial genes will be reviewed, with emphasis on the potato plant. [less ▲]

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