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See detailSH2 domain containing inositol 5-phosphatases 1 and 2 in blood platelets: interaction and respective role in the control of phosphatidylinositol 3,4,5-trisphosphate levels
Giuriato, S.; Pesesse, X.; Bodin, S. et al

in Biochemical Journal (2003), 376

Src homology domain 2-containing inositol 5-phosphatases 1 and 2 (SHIP1 and SHIP2) are capable of dephosphorylating the second messenger PtdIns(3,4,5) P3 (phosphatidylinositol 3,4,5-trisphosphate) and ... [more ▼]

Src homology domain 2-containing inositol 5-phosphatases 1 and 2 (SHIP1 and SHIP2) are capable of dephosphorylating the second messenger PtdIns(3,4,5) P3 (phosphatidylinositol 3,4,5-trisphosphate) and interacting with several signalling proteins. SHIP1 is essentially expressed in haematopoietic cells, whereas SHIP2, a closely related enzyme, is ubiquitous. In the present study, we show that SHIP1 and SHIP2 are expressed as functional PtdIns(3,4,5) P3 5-phosphatases in human blood platelets and are capable of interacting when these two lipid phosphatases are co-expressed, either naturally (platelets and A20 B lymphoma cells) or artificially (COS-7 cells). Using COS-7 cells transfected with deletion mutants of SHIP2, we demonstrate that the Src homology domain 2 of SHIP2 is the minimal and sufficient protein motif responsible for the interaction between the two phosphatases. These results prompted us to investigate the relative importance of SHIP1 and SHIP2 in the control of PtdIns(3,4,5) P3 levels in platelets using homozygous or heterozygous SHIP1- or SHIP2-deficient mice. Our results strongly suggest that SHIP1, rather than SHIP2, plays a major role in controlling PtdIns(3,4,5) P3 levels in response to thrombin or collagen activation of mouse blood platelets [less ▲]

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See detailFestina lente: evidences for fast and slow learning processes and a role for sleep in human motor skill learning.
Maquet, Pierre ULg; Laureys, Steven ULg; Perrin, Fabien et al

in Learning & Memory (Cold Spring Harbor, N.Y.) (2003), 10(4), 237-9

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See detailInfluence of copper(II) salt on the reaction of peroxynitrite with propofol
Kohnen, Stephan ULg; Mouithys-Mickalad, Ange ULg; Deby-Dupont, G. et al

in Free Radical Research (2003), 37(Suppl. 1), 106

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See detailSaint Remacle de Malmedy et de Stavelot. Entre mythe et réalité
George, Philippe ULg

in Les moines à Stavelot-Malmedy du VIIe au XXIe siècle, Actes du colloque « Le monastère de Wavreumont dans l’histoire » (1-3 mars 2001) (2003)

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See detailDouble radial immunodiffusion as a tool to identify pregnancy-associated glycoproteins in ruminant and nonruminant placentae
El Amiri, B.; Melo de Sousa, Noelita ULg; Mecif, K. et al

in Theriogenology (2003), 59(5-6), 1291-1301

Pregnancy-associated glycoproteins (PAGs) are antigens synthesized in the superficial layers of the ruminant trophoblast. Initially, they were identified either as proteins released into the maternal ... [more ▼]

Pregnancy-associated glycoproteins (PAGs) are antigens synthesized in the superficial layers of the ruminant trophoblast. Initially, they were identified either as proteins released into the maternal bloodstream (where they have applications in pregnancy diagnosis) (PAG1) or as molecules binding to the LH receptor (PAG2). In this study, double radial immunodiffusion was used to test the ability of antisera raised against different PAG molecules (bovine, ovine and caprine) to react with placental extracts from nonruminants (rabbit, cat, mouse, pig, and wild pig) and ruminants (cow, ewe, and goat). Placental extracts from all nonruminants tested except rabbit reacted with anti bovine PAG2 (anti-boPAG2). Extracts of ruminant placentas reacted with different antisera, confirming the expression of various PAG molecules. According to the time at which the placentas were collected (early or middle pregnancy), the reaction differed as regards the thickness, position, and number of precipitation lines, suggesting that PAG expression varies as pregnancy progresses. Bos indicus and Bos taurus placental extracts exhibited different reactions with anti-boPAG2: a single precipitation line in the former case and two lines in the latter. This suggests differential expression of boPAG2 related glycoproteins in these two subspecies. [less ▲]

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See detailVerberie - Le Buisson Campin, Oise (60667001): Rapport de Fouilles Programmées Pluriannuelles, 2000-2002
Audouze, Françoise; Enloe, James G.; Janny, F. et al

Report (2003)

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See detailLe médicament du mois Le voriconazole (Vfend).
Pierard, Gérald ULg; Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2003), 58(5), 351-5

Invasive fungal infections are a rare but important cause of morbidity and mortality among patients with severely compromised host defenses. Despite considerable advances in antifungal therapies over the ... [more ▼]

Invasive fungal infections are a rare but important cause of morbidity and mortality among patients with severely compromised host defenses. Despite considerable advances in antifungal therapies over the past years, invasive mycoses remain a stubborn and dramatic problem. Voriconazole is a new triazole antifungal agent which confers a relative survival benefit in fluconazole-resistant invasive candidiasis, and in invasive aspergillosis, fusariosis and Scedosporium infections as well. [less ▲]

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See detailOld Cairo Development Project
Attia, Shady ULg; Zakareya, Mona

Diverse speeche and writing (2003)

Article about the development of Old Cairo, the historic centre in Cairo, Egypt. (arabic).

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See detailUsing on-site observations for low back related work load assessment - Methodological issues
Somville, Pierre-René ULg; Mairiaux, Philippe ULg

in Strasser, H.; Kluth, K.; Rausch, H. (Eds.) et al Quality of work and products in enterprises of the future (2003)

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See detailConfinement and cut-off: A model for the Pion Quark Distribution Function
Stassart, Pierre ULg; Bissey, F.; Cudell, Jean-René ULg et al

(2003)

The pion structure function is investigated in a simple pseudo-scalar coupling model of pion and constituent quark fields. The imaginary part of the forward Compton scattering amplitude is evaluated. We ... [more ▼]

The pion structure function is investigated in a simple pseudo-scalar coupling model of pion and constituent quark fields. The imaginary part of the forward Compton scattering amplitude is evaluated. We show that the introduction of non-perturbative effects, linked through a cut-off to the size of the pion, allows the reproduction of important features of the pion quark distribution function. [less ▲]

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See detailThe impact of reimbursement criteria on the appropriateness of 'statin' prescribing.
Autier, Philippe; Creplet, Jean; Vansant, Greet et al

in European Journal of Cardiovascular Prevention & Rehabilitation (2003), 10(6), 456-62

BACKGROUND: In Belgium, regulations restrict the reimbursement of statins to patients with total serum cholesterol above 250 mg/dl (6.41 mmol/l) after a three-month lipid-lowering diet. We investigated ... [more ▼]

BACKGROUND: In Belgium, regulations restrict the reimbursement of statins to patients with total serum cholesterol above 250 mg/dl (6.41 mmol/l) after a three-month lipid-lowering diet. We investigated the possible impact of these regulations on characteristics of Belgian patients receiving a lipid-lowering drug. DESIGN: From 1998 to 2000, standard questionnaires on coronary risk factors and treatments with lipid-lowering drugs were completed by 301 GPs sampled at random in the 11 Belgian Provinces. Questionnaires had to be completed for 18 consecutive patients 35 years old or more attending GPs' practices, irrespective of the underlying motive for attendance. RESULTS: Of the 5511 patients included in the study, 1519 (28%) had established coronary disease or diabetes mellitus, or > or = 2 non-cholesterol coronary risk factors. Most (70%) of these patients were not treated with a lipid-lowering drug. Only 22% of patients with established coronary disease, 10% of patients with diabetes mellitus and 9% of patients with > or = 2 coronary risk factors were treated with a statin. Fifty-nine percent of fibrate users and 50% of statin users had a pre-treatment cholesterol level above 250 mg/dl, but had no or only one non-cholesterol coronary risk factor. CONCLUSIONS: In Belgium, the majority of patients at higher risk of coronary event do not benefit from lipid-lowering drugs, particularly the statins. In contrast, one of two statin users and three of five fibrate users should probably not receive the drug prescribed. Regulation based on blood cholesterol level encourages the overlooking of other risk factors relevant for selecting patients having the greatest chance to benefit from statin treatment. [less ▲]

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See detailPreoperative hyperfractionated acclerated radiotherapy (HART) and concomittant CPT-11 in advanced rectal carcinoma. A phase I study.
Voelter, V; Stupp, R; Matter, M et al

in International Journal of Radiation, Oncology, Biology, Physics (2003), 56(5), 1288-1294

Purpose: Patients with locally advanced rectal carcinoma are at risk for both local recurrence and distant metastases. We demonstrated the efficacy of preoperative hyperfractionated accelerated ... [more ▼]

Purpose: Patients with locally advanced rectal carcinoma are at risk for both local recurrence and distant metastases. We demonstrated the efficacy of preoperative hyperfractionated accelerated radiotherapy (HART). In this Phase I trial, we aimed at introducing chemotherapy early in the treatment course with both intrinsic antitumor activity and a radiosensitizer effect. Methods and Materials: Twenty-eight patients (19 males; median age 63, range 28–75) with advanced rectal carcinoma (cT3: 24; cT4: 4; cN : 12; M1: 5) were enrolled, including 8 patients treated at the maximally tolerated dose. Escalating doses of CPT-11 (30–105 mg/m2/week) were given on Days 1, 8, and 15, and concomitant HART (41.6 Gy, 1.6 Gy bid 13 days) started on Day 8. Surgery was to be performed within 1 week after the end of radiochemotherapy. Results: Twenty-six patients completed all preoperative radiochemotherapy as scheduled; all patients underwent surgery. Dose-limiting toxicity was diarrhea Grade 3 occurring at dose level 6 (105 mg/m2). Hematotoxicity was mild, with only 1 patient experiencing Grade 3 neutropenia. Postoperative complications (30 days) occurred in 7 patients, with an anastomotic leak rate of 22%. Conclusions: The recommended Phase II dose of CPT-11 in this setting is 90 mg/m2/week. Further Phase II exploration at this dose is warranted. © 2003 Elsevier Inc. [less ▲]

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See detailRecognising the usual orientation of one's own face : the role of asymmetrically located details
Brédart, Serge ULg

in Perception (2003), 32(7), 805-811

Our ability to recognise the usual horizontal orientation Of Our own face (mirror orientation) as compared with another very familiar face (normal orientation) was examined in experiment 1. Participants ... [more ▼]

Our ability to recognise the usual horizontal orientation Of Our own face (mirror orientation) as compared with another very familiar face (normal orientation) was examined in experiment 1. Participants did not use the same kind of information in determining the orientation of their own face as in determining the orientation of the other familiar face. The proportion of participants who reported having based their judgment on the location of an asymmetric feature (eg a mole) was higher when determining the orientation of their own face than when determining that of the other familiar face. In experiment 2, participants were presented with pairs of manipulated images of their own face and of another familiar face showing conflicting asymmetric features and configural information. Each pair consisted of one picture showing asymmetric features of a given face in a mirror-reversed position, while the facial configuration was left unchanged; and one picture in which the location of the asymmetric features was left unchanged, while the facial configuration was mirror-reversed. As expected from the hypothesis that asymmetric local features are more frequently used for the judgment of one's own face, participants chose the picture showing mirror-reversed asymmetric features when determining the usual orientation of their own face significantly more often than they chose the picture showing normally oriented asymmetric features when determining the orientation of the other face. These results are explained in terms of competing forward and mirror-reversed representations of one's own face. [less ▲]

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See detailL’émergence d’un marché d’immobilier d’entreprise. L’exemple de la Wallonie
Merenne-Schoumaker, Bernadette ULg

in Géocarrefour (2003), 78

In less than ten years, a business property market has emerged in Wallonia. This market first concerned offices and retail units (a sector not studied in this paper) and, more recently, semi-industrial ... [more ▼]

In less than ten years, a business property market has emerged in Wallonia. This market first concerned offices and retail units (a sector not studied in this paper) and, more recently, semi-industrial establishments. Its development is largely related to the creation of new demands in physical units, environment and accessibility, as well as in location choices, at both sub-regional and local scales. It has been favoured by the arrival of new property stakeholders from Belgium and abroad (developers, investors and property agents), as well as by public authorities (the Walloon Region and, more importantly, supra-communal, economic development agencies). The emergence of this market is related to the accentuation of territorial contrasts as property development projects usually reinforce strong area [less ▲]

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See detailUne recherche-action pour développer les capacités de compréhension de l’écrit en 1re accueil … Premier bilan
Schillings, Patricia ULg; Poncelet, Débora

in Point sur la Recherche en Education (Le) (2003)

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See detailCrème & beurre.
Blecker, Christophe ULg

in Cours laitiers pour ouvriers (2003)

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See detailOrganisme génétiquement modifié
du Jardin, Patrick ULg

in Morère, Jean-Louis; Pujol, Raymond (Eds.) Dictionnaire raisonné de Biologie (2003)

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See detailCase 61: ileocecal sarcoidosis.
NCHIMI LONGANG, Alain ULg; Francotte, Nadine; Rausin, Leon et al

in Radiology (2003), 228(2), 452-5

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See detailInclusions and Carbides characterisation in High-Speed Steels
Tchuindjang, Jérôme Tchoufack ULg; Lecomte-Beckers, Jacqueline ULg

in Proceedings de la journée de la société belge de microscopie (SBM-BVM), RUCA, UA (2003)

Prior to assessment of inclusions and carbides is the identification of thes particles. The present survey shows how we determine the nature of inclusions and carbides, while using Scanning Electron ... [more ▼]

Prior to assessment of inclusions and carbides is the identification of thes particles. The present survey shows how we determine the nature of inclusions and carbides, while using Scanning Electron Microscopy and Energy Dispersive Spectroscopy with X-Rays. [less ▲]

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