References of "2003"
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See detailComment je traite ... les troubles de la magnésémie
Guillaume, Thierry; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2003), 58(7-8), 465-467

Because symptoms associated with hypomagnesia are highly aspecific, this ionic abnormality is rarely searched for although it could be present in as much as 20 % of the population. The mode of correction ... [more ▼]

Because symptoms associated with hypomagnesia are highly aspecific, this ionic abnormality is rarely searched for although it could be present in as much as 20 % of the population. The mode of correction (oral or intravenous) depends on the etiology, severity and clinical consequences of hypomagnesemia. Significant hypermagnesemia only occurs in the presence of renal insufficiency and/or acute excess administration, mainly by the intravenous route. If interruption of administration does not suffice, renal dialysis might become necessary to quickly correct the magnesemium serum levels. [less ▲]

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See detailAutoimmunity associated with anti-tumor necrosis factor alpha treatment in Crohn's disease: A prospective cohort study
Vermeire, S.; Noman, M.; Van Assche, G. et al

in Gastroenterology (2003), 125(1), 32-39

Background & Aims: Infliximab therapy is an effective approach to treating Crohn's disease. Development of antinuclear antibodies has been described in patients treated, but the size of the problem and ... [more ▼]

Background & Aims: Infliximab therapy is an effective approach to treating Crohn's disease. Development of antinuclear antibodies has been described in patients treated, but the size of the problem and the relationship with autoimmunity have not been investigated. We investigated the occurrence of antinuclear antibodies in 125 consecutive Crohn's disease patients and studied the relationship with symptoms of autoimmunity. Methods: Autoantibodies and clinical data were investigated before and 1, 2, and 3 months after infliximab infusion. If antinuclear antibodies were greater than or equal to1:80, further study of double-stranded DNA, single-stranded DNA, histones, and ENA was performed. Results: Cumulative antinuclear antibody incidence at 24 months was 71 of 125 (56.8%). Almost half of these patients developed antinuclear antibodies after the first infusion, and >75% became antinuclear antibody positive after fewer than 3 infusions. So far, only :15 of 71 patients have become seronegative, after a median of 12 months. Of 43 antinuclear antibody-positive patients who were further subtyped, 14 of 43 (32.6%) had double-stranded DNA, 17 (39.5%) had single-stranded DNA, 9 (20.9%) had antihistone, and 0% were ENA positive. Two patients (both antihistone and double-stranded DNA positive) developed drug-induced lupus without major organ damage, and I developed autoimmune hemolytic anemia. Antinuclear antibodies were associated with the female sex (odds ratio, 3.166; 95% confidence interval, 1.167-8.585; P = 0.024) and with papulosquamous or butterfly rash (odds ratio, 10.016; 95% confidence interval, 1.708-58.725; P = 0.011). Conclusions: The cumulative incidence of antinuclear antibodies was 56.8% after 24 months in this cohort of infliximab-treated Crohn's disease patients. Antinuclear antibodies persisted up to I year after the last infusion, and only a few patients became seronegative. Two patients developed drug-induced lupus erythematosus. Antinuclear antibodies were associated with the female sex and skin manifestations. [less ▲]

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See detailBehavioral characterization of acetaldehyde in C57BL/6J mice: Locomotor, hypnotic and ataxic effects
Quertemont, Etienne ULg; Tambour, Sophie ULg; Tirelli, Ezio ULg

in Behavioural Pharmacology (2003), 14(Suppl. 1), 69-69

Acetaldehyde, the first ethanol metabolite, was recently suggested to play a major role in many behavioral effects of ethanol. However, no studies have directly investigated the behavioral effects of ... [more ▼]

Acetaldehyde, the first ethanol metabolite, was recently suggested to play a major role in many behavioral effects of ethanol. However, no studies have directly investigated the behavioral effects of acetaldehyde after acute administration. Therefore, the aim of the present study was to characterize the locomotor, hypnotic and ataxic effects of acetaldehyde in C57BL/6J mice. Various acetaldehyde doses (0-300 mg/kg) were injected intraperitoneally and their effects were investigated with several classical behavioral tests. The locomotor effects of acetaldehyde were measured in standard activity boxes. In addition, the loss of righting reflex was used to assess the hypnotic effects of acetaldehyde. Finally, the ataxic effects of acetaldehyde were studied with the horizontal wire test. The results show that acetaldehyde induced a significant hypolocomotor effect at 170 mg/kg and higher doses. In addition, the hypnotic effects of acetaldehyde were evidenced by a loss of righting reflex in doses between 170 and 300 mg/kg. However, the locomotor and hypnotic effects of acetaldehyde were very brief relative to what is observed after ethanol administration. After 170 mg/kg acetaldehyde, normal activity was recovered in less than 30 minutes and the loss of righting reflex lasted only an average of 6.14 ± 1.29 minutes after the administration of 300 mg/kg acetaldehyde, the highest testable dose before lethality. Ataxic effects were observed with lower doses that did not significantly affect locomotor activity. These results show that acetaldehyde, like ethanol, possesses sedative, hypnotic and ataxic properties and therefore indicate that the first product of ethanol metabolism might be involved in these ethanol effects. [less ▲]

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See detailDéveloppement : la course à la compétitivité
Lebailly, Philippe ULg; Gobillon, L.

Article for general public (2003)

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See detailPET scan imaging in oncology.
Jerusalem, Guy ULg; Hustinx, Roland ULg; Beguin, Yves ULg et al

in European Journal of Cancer (2003), 39(11), 1525-34

With the emergence of positron emission tomography (PET) from research laboratories into routine clinical use, it is important to redefine the most appropriate use of each imaging technique. The aim of ... [more ▼]

With the emergence of positron emission tomography (PET) from research laboratories into routine clinical use, it is important to redefine the most appropriate use of each imaging technique. The aim of this review article is to show the potential of PET in oncology. We discuss the most promising indications and the perspectives for the future. We will also point out the shortcomings and the important questions to be answered before fully considering PET as a necessary tool in the day-to-day practice of oncology. Although many studies have documented the high accuracy of 18F-FDG PET for the detection and staging of malignant tumours and for the monitoring of therapy results in these patients, it is very important to assess the impact of the technique on patient outcome and to show cost-effectiveness from the societal viewpoint. [less ▲]

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See detailNumerical mdeling of hydro-mechanical fracture behaviour
Guiducci, Chiara; Collin, Frédéric ULg; Radu, Jean-Pol ULg et al

Conference (2003)

A numerical approach for modeling coupled Hydro-Mechanical fracture behavior in 2D is presented in this paper. This approach accounts for the strong dependence of the flow characteristics on fracture ... [more ▼]

A numerical approach for modeling coupled Hydro-Mechanical fracture behavior in 2D is presented in this paper. This approach accounts for the strong dependence of the flow characteristics on fracture apertures and offers an anisotropic description of the flow propagation in the fracture. An interface finite element and a constitutive model are developed . In order to validate the applicability of the model to general geomechanic problems, 2D simulations were performed. Results show the good application of the mathematical model and the fundamental hydraulic role played by the fractures. [less ▲]

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See detailIl conflitto sulla regolarizzazione dei sans-papiers in Belgio
Martiniello, Marco ULg; Kagné, Bonaventure

in Basso, Pietro; Perocco, Fabio (Eds.) Gli immigrati in Europa. Disegualianze, razzismo, lotte (2003)

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See detailExternal quality grading of Jonagold apples using a multi-spectral vision system
Kleynen, Olivier; Leemans, Vincent ULg; Destain, Marie-France ULg

in Balsa-Canto E., Mora J.; Onate E. (Eds.) II International Workshop - Information Technologies and Computing Techniques for the Agro-Food Sector (2003)

This paper presents a method to sort Jonagold apples using a four bands multi-spectral image acquisition device. Multi-spectral images of sound tissue and various defects were acquired. Defects could be ... [more ▼]

This paper presents a method to sort Jonagold apples using a four bands multi-spectral image acquisition device. Multi-spectral images of sound tissue and various defects were acquired. Defects could be divided into four classes: slight defects (e.g. small russet), more serious defects (scar tissue), defects leading to the rejection of the fruit (e.g. rot) and recent bruises (between one hour and two hours old). Image segmentation was based on the Bayes' theorem. Each pixel of the fruit was classified into 'healthy' or 'defect' classes according to the probability distribution of the spectral components of each class. Once segmented, the fruit was graded by linear discriminant analysis on the basis of the relative area of the defect and statistical parameters computed on the spectral components of the two tissues classes. Results (cross validation) showed 94% and 84% if the sound and defective fruits respectively well classified. Most of the misclassified defective fruits (89%) belonged to the slight defect category. [less ▲]

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See detailOptimieren Sie ihr Haus
Guillemeau, Jean-Marc ULg; Hauglustaine, Jean-Marie ULg; Wagelmans, Paul ULg

Book (2003)

This booklet is intended to inform each and everyone on the possibilities of optimizing its dwelling, in the observance of the thermal regulation of the Walloon region: since the choice of the ground ... [more ▼]

This booklet is intended to inform each and everyone on the possibilities of optimizing its dwelling, in the observance of the thermal regulation of the Walloon region: since the choice of the ground until the precautions of implementation. [less ▲]

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See detailReactive oxygen species downregulate the expression of pro-inflammatory genes by human chondrocytes.
Mathy, Marianne ULg; Martin, G.; Devel, P. et al

in Inflammation Research (2003), 52(3), 111-8

OBJECTIVES: To determine the regulatory effects of reactive oxygen species (ROS) on the expression by human osteoarthritic chondrocytes of interleukin (IL)-1beta, -6 and -8, inducible nitric oxide ... [more ▼]

OBJECTIVES: To determine the regulatory effects of reactive oxygen species (ROS) on the expression by human osteoarthritic chondrocytes of interleukin (IL)-1beta, -6 and -8, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) gene in response to interleukin (IL)-1beta or lipopolysaccharide (LPS). METHODS: Human chondrocytes in monolayer culture were incubated for 3 h with ROS generating molecules such as S-nitroso-N-acetyl-D,L-penicillamine (SNAP, 100 microM), 3-morpholinosydnonimine (SIN-1, 100 microM), with chemically synthesised peroxynitrite (ONOO-, 10 microM) or hydrogen peroxide (H2O2, 100 microM). After treatment by ROS, chondrocytes were washed and then cultured for the next 24 h with or without lipopolysaccharide LPS (10 microg/ml) or IL-1beta (1.10(-11) M). IL-1beta, IL-6, IL-8, iNOS and COX-2 gene expression was analysed by real time and quantitative RT PCR. IL-6, IL-8 and prostaglandin (PG) E2 productions were assayed by specific immunoassays. Nitrite was measured in the culture supernatants by the Griess procedure. RESULTS: LPS and IL-1beta stimulated IL-1beta, IL-6, IL-8, iNOS and COX-2 gene expression. SNAP significantly downregulated LPS induced overall gene expressions, whereas SIN-1 had no effect. ONOO- inhibited iNOS and COX-2 gene expression but not that of the cytokine genes. When chondrocytes were incubated with IL-1beta, SIN-1 and ONOO dramatically decreased all gene expressions while SNAP was inefficient. H2O2 treatment inhibited both LPS and IL-1beta induced gene expressions. CONCLUSIONS: These data provide an evidence that ROS may have anti-inflammatory properties by depressing inflammatory gene expression. Further, we demonstrate that ROS effects are dependent on the nature of radical species and the signalling pathway that is activated. These findings should be taken into consideration for the management of antioxidant therapy in treatment of inflammatory joint diseases. [less ▲]

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See detailL'évaluation des troubles de la mémoire dans le cadre de l'expertise médico-légale
Meulemans, Thierry ULg

in Meulemans, Thierry (Ed.) Evaluation et prise en charge des troubles mnésiques (2003)

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See detailIntensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphoma
Tilly, Hervé; Lepage, Eric; Coiffier, Bertrand et al

in Blood (2003), 102(13), 4284-4289

We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide ... [more ▼]

We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) in previously untreated patients with poor-risk aggressive lymphoma. Patients aged 61 to 69 years who had aggressive non-Hodgkin lymphoma with at least one prognostic factor of the age-adjusted international prognostic index (IPI) were included. ACVBP consisted of an induction phase of intensified chemotherapy and central nervous system (CNS) prophylaxis followed by a sequential consolidation phase. Of the 708 patients registered for the study, 635 were eligible. The rate of complete response was 58% in the ACVBP group and 56% in the CHOP group (P =.5). Treatment-related death occurred in 13% of the ACVBP group and 7% of the CHOP group (P =.014). At 5 years, the event-free survival was 39% in the ACVBP group and 29% in the CHOP group (P =.005). The overall survival was significantly longer for patients treated with ACVBP, at 5 years it was 46% compared with 38% for patients treated with CHOP (P =.036). CNS progressions or relapses were more frequent in the CHOP group (P =.004). Despite higher toxicity, the ACVBP regimen, used as first-line treatment for patients with poor-risk aggressive lymphoma, is superior to standard CHOP with regard to both event-free survival and overall survival. (C) 2003 by The American Society of Hematology. [less ▲]

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See detailShakespeare et Hamlet sur la toile
Delville, Michel ULg; Michel, Pierre ULg

Textual, factual or bibliographical database (2003)

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See detailTutorat. Définitions, justifications théoriques et illustrations.
Poumay, Marianne ULg

Learning material (2003)

Ce document de 25 pages introduit la notion de tutorat en eLearning et discute différentes notions issues de l'émergence des pratiques de tutorat. Il fait un large usage du contenu d'un chapitre sur le ... [more ▼]

Ce document de 25 pages introduit la notion de tutorat en eLearning et discute différentes notions issues de l'émergence des pratiques de tutorat. Il fait un large usage du contenu d'un chapitre sur le même sujet, publié dans un ouvrage de Bernath (université de Oldenburg) et référencé en début de document. [less ▲]

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See detailPhosphate mineral occurrences in Lake Baïkal sediments : Paleo-environment or diagenesis record ?
Fagel, Nathalie ULg; Alleman, L. Y.; André, Luc et al

Poster (2003)

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See detailVisual urban space assessment from sky shape analysis
Teller, Jacques ULg; Sarradin, F.; Siret, D.

in Gnauck, A.; Heinrich, R. (Eds.) Informatics for Environmental Protection: The Information Society and Enlargement of the European Union (EnviroInfo 2003) (2003)

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See detailLa Belgique de Jacques Yerna
Jamin, Jérôme ULg; Dohet, Julien

Book published by Labor (2003)

L'ouvrage revisite l'histoire récente de la Belgique depuis la Deuxième guerre mondiale jusqu'à nos jours par le biais d'entretiens avec le syndicaliste liégeois Jacques Yerna.

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See detailUrban use of VHR images on Bukavu (Democratic Republic of Congo)
Binard, Marc ULg; De Man, J.; Séba, G. et al

in Proceedings of the Second Workshop of the EARSeL Special Interest Group on Remote Sensing for Developing Countries, Bonn, Germany September 18-20, 2002. EARSeL: Paris, France. (2003)

The main purpose of this study was to show potential uses of very high resolution (VHR) image in an urban analysis of Bukavu in the Democratic Republic of Congo. As for many of the Third-World cities ... [more ▼]

The main purpose of this study was to show potential uses of very high resolution (VHR) image in an urban analysis of Bukavu in the Democratic Republic of Congo. As for many of the Third-World cities, Bukavu grew up during the last decades and available topographical information on Bukavu dates back to the middle of the twentieth century. This lack of updated information can be compensated by an appropriate use of VHR images. In this study, IKONOS image recorded on the 14th February 2001 was used. Image registration are highly dependant on accurate Digital Elevation Models (DEM), these last ones are also useful in urban analyses. The range between the minimum and maximum altitudes observed in the image was more than 500 meters. Furthermore, the viewing inclination angle is more than 28 degrees. In this case, orthorectification is mandatory for correcting relief displacements. Nevertheless, the lack of good Ground Control Points (GPS’s) on the old topographic maps and the failure to collect field verification data in Bukavu explains the remaining global 2D RMSE of 10 meters. For easier image interpretation, multispectral (4m) and panchromatic (1m) images were fused together by means of the LMVM algorithm. Depending on the object, the Computer Aided Photo Interpretation (CAPI) uses or does not use the near infrared information (true or false colour composite). For a more detailed interpretation about the city morphology we draped the 1m multispectral fused image over the 1m resolution DEM grid. The Built-up Area Index (BAI) computed on the urban mask obtained by CAPI and classification of the vegetation, was compared with the 1954 situation interpreted from topographic maps. The present city shows higher BAI values and in the same time the centre of the city has clearly shifted southward. Statistical analyses are also done on built-up versus slope data. The lack of good GCP’s and the use of DEM produced inaccurate orthorectification which was not adequate for topographical features extraction. Nevertheless the present extensions of Bukavu built-up areas are more than the double of those observed at the beginning of the last half century. New constructions are located on steeper slopes where landslides are frequents. More features could be extracted from the Ikonos image if good GPS measurements were made and if verification by the city authorities was possible. Some practical applications of this study could involve determining better location of new Bukavu extensions. [less ▲]

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See detailOn the combination of corpus-based and experimental methodologies in the study of causal, contrastive and metadiscourse connectives in L1 and L2 text comprehension and production
Perrez, Julien ULg; Degand, Liesbeth

in Archer, Dawn; Rayson, Paul; Wilson, Andrew (Eds.) et al Proceedings of the Corpus Linguistics 2003 Conference (2003)

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