References of "2003"
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See detailSeismically triggered landslides: a conceptual model for deformation mechanisms and influencing factors
Havenith, Hans-Balder ULg

in EGS-AGU-EUG Joint Assembly (2003)

Abstract: Different types of landslides known or assumed to have been triggered by a specific earthquake were investigated at different places in the Tien Shan (Central Asia). Geophysical and geological ... [more ▼]

Abstract: Different types of landslides known or assumed to have been triggered by a specific earthquake were investigated at different places in the Tien Shan (Central Asia). Geophysical and geological data recorded at these sites allowed us to determine the geometry of the mass movements and environmental features that had contributed to the failure. From the observations and related numerical analyses, it could be inferred that four site factors have a significant influence upon sliding processes: morphology; type of ... [less ▲]

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See detailAirborne pulse-Doppler radar and early forms of radar space-time processing
Verly, Jacques ULg

Scientific conference (2003)

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See detailStable isotopes and fatty acids used as biomarkers to distinguish among Antarctic amphipods trophic guilds
Nyssen, Fabienne ULg; Graeve, Martin

Conference (2003)

Peracarid crustaceans and amphipods in particular are an important group in the Southern Ocean and one of the most diverse in the macrozoobenthos (Jazdzewski et al., 1991). As a part of a ... [more ▼]

Peracarid crustaceans and amphipods in particular are an important group in the Southern Ocean and one of the most diverse in the macrozoobenthos (Jazdzewski et al., 1991). As a part of a multidisciplinary study of the amphipods ecological roles in Antarctic benthic systems (De Broyer et al., 2001, Nyssen et al., 2002), about 150 specimens belonging to 25 species of 10 of the most common amphipod families occurring in the Southern Ocean have been involved in this study of amphipod trophic patterns. Beside “classical” stomach content analysis or field observations, the use of naturally occurring stable isotopes of carbon (δ13C) and nitrogen (δ15N) has recently provided new insights into food web ecology (Hobson & Welch, 1992, Lepoint et al., 2000). This method is based on the direct relationship established between the isotopic signature of an organism and that of its preys (DeNiro & Epstein, 1978, 1981, Peterson & Fry, 1987). Nitrogen-15 typically shows a step-wise increase with trophic level within a food chain (Cabana & Rasmussen, 1994). Closer to the value of the diet, carbon-13 is preferentially used to assess the relative proportion of potential primary sources in a trophic web (ex.: pelagic vs benthic contribution to food intake) (Dauby et al., 1998, Hobson et al., 1995). Furthermore, for several species, the lipid signature – which has already been used successfully to help understand marine trophodynamics (Graeve et al., 2001, Nelson et al., 2001, Phleger et al. 1998) – and more particularly the fatty acid composition has been investigated as trophic biomarkers to reveal more precisely to which trophic guild they belong to. [less ▲]

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See detailInvestigation of transverse cracks initiation in continuous steel casting using a finite element approach
Castagne, S.; Habraken, Anne ULg

in Advances in Computational & Experimental Engineering (2003)

A numerical model for steel at elevated temperature which is based on a mesoscopic finite element approach is presented. The objective of the research is the analysis of damage evolution in the material ... [more ▼]

A numerical model for steel at elevated temperature which is based on a mesoscopic finite element approach is presented. The objective of the research is the analysis of damage evolution in the material using information from the macroscopic and microscopic scales. As a final application our results are used to study the industrial process of continuous casting of low carbon steel. [less ▲]

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See detailUrticaire de contact suite à l’application d’un fond de teint contenant de l’huile de sésame
Dezfoulian, Bita ULg; de LA BRASSINNE, Michel ULg

in Revue Française d'Allergologie et d'Immunologie Clinique (2003), 43

A number of cosmetic products containing sesame oil are used for daily cutaneous care. The risk of secondary induction of eczema or even anaphylactic shock after topical use of products containing ... [more ▼]

A number of cosmetic products containing sesame oil are used for daily cutaneous care. The risk of secondary induction of eczema or even anaphylactic shock after topical use of products containing vegetable oils is still unknown. We describe the case of 36-years-old atopic, sesame sensitized women who presented with contact urticaria after application of a foundation cream containing sesame oil. Immediate prick and patch tests with sesame oil, sesame grains, the foundation cream and its components confirmed this sensitization. We discuss the innocuousness of vegetable and animal products present in foods and in cosmetics and problems that may occur when they are used by patients during an inflammatory phase of atopic dermatitis and by patients with specific sensitization to these allergens. [less ▲]

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See detailAvantages sélectifs d'un phénotype hétérochronique. Eco-éthologie des populations pédomorphiques du Triton alpestre, Triturus alpestris (Amphibia, Caudata)
Denoël, Mathieu ULg

Book published by Cahiers d'Ethologie (2003)

Facultative paedomorphosis is a polyphenism that has important evolutionary implications in promoting morphological differentiation and habitat use variation, and has occurred in several urodele species ... [more ▼]

Facultative paedomorphosis is a polyphenism that has important evolutionary implications in promoting morphological differentiation and habitat use variation, and has occurred in several urodele species throughout the world. Several hypotheses based on life-history theory have been proposed to explain the wide range of habitats where facultative paedomorphosis occurs, suggesting multiple causes. In populations experiencing facultative paedomorphosis, some individuals metamorphose and mature (metamorphs), while others attain sexual maturity while still retaining traits of larval somatic morphology (paedomorphs). The paedomorphic process by which the development of somatic and reproductive organs is shifted between related individuals is assumed to significantly contribute to macro-evolutionary processes. Indeed, it implies large phenotypic variations in the absence of deep genetic changes. A way to explain the importance of these developmental heterochronies is to show their adaptive value in the micro-evolutive stage. The aim of this thesis is to determine the advantages gained by an individual that adopts a paedomorphic developmental pathway rather than a metamorphic one. To do this, we studied five factors: habitat use; resource partitioning; age and size structures; sexual compatibility; and the effect of environmental factors. The ecological and ethological characteristics of several mixed populations (composed of both paedomorphic and metamorphic individuals) of the Alpine newt Triturus alpestris (Amphibia, Salamandridae) were investigated from 1997 to 2000. These populations were located in France, Italy and Greece. The habitats occupied by dimorphic populations of the Alpine newt are highly variable. We have found the two morphs in syntopy in deep permanent lakes, and in small shallow and temporary ponds. Aquatic habitats were surrounded by various terrestrial habitats. As a result, it was not possible to correlate any particular environment type with the maintenance of the polymorphism in natural populations. The only common trait of the paedomorphic populations was that they were located at the southern margin of the range of the species (Italy, the Balkan peninsula, and southeastern France). Such a restriction of the distributional range of paedomorphosis suggests that this trait is maintained by genes which are shared only by these populations. Such a restriction may be due to Holocene colonizations from Pleistocene refugia, in which case paedomorphosis may have appeared in these refugia during the last glaciations. Nevertheless, as long as the phylogeny of the group remains uncertain, we cannot reject the possibility of an earlier origin of paedomorphosis. The two morphs primarily differed in space use and feeding habits. These differences were particularly marked in deep alpine aquatic habitats, where the paedomorphs occupy deep waters devoid of competitors, such as fish. In such waters, the paedomorphs were more abundant on the bottom and in the water column, whereas the metamorphs mainly occupied the water surface and shore. The paedomorphs primarily ingested plankton, while the metamorphs mainly foraged on terrestrial prey that had fallen on the water surface. Although these feeding habits depend on newt habitats - plankton being more abundant in the water column, and terrestrial prey at the water surface - the trophic spectrum in each habitat still differed. While the energetic values of the prey eaten by the two morphs strongly differed, by ingesting a large number of planktonic organisms, the paedomorphs attained similar or even larger caloric intake rates than metamorphs. The paedomorphs' superior body condition suggests that they may have higher long-term success than the metamorphs. Differences in body condition may also reflect the terrestrial life habit of the metamorphs, since metamorphosed individuals are able to avoid competition with reproductive adults and larvae by leaving the water. In the paedomorphic populations, several size-structured cohorts of larvae coexist, and competition among these cohorts is lowered by size-selective predation, since small larvae catch smaller prey than larger larvae and paedomorphs. Although this difference in diet was in part due to gape-size limitation, the gilled individuals also size-selected prey among a range of catchable items. Resource partitioning then favoured the coexistence of the two adult morphs, and their gilled descendants, which coexist with them. The two morphs also differed in feeding performance. Whereas the paedomorphs were better predators than metamorphs on water fleas, metamorphs were more adept at capturing large terrestrial invertebrates (flies). These differences in feeding performances were caused by the morphological particularities of the two morphs. Paedomorphs had a fish-like feeding structure with a unidirectional water flow passing through the oral cavity, and then being expelled through gill slits on the posterior side of the head. In contrast, metamorphs had a smaller oral cavity and a bidirectional water flow due to closed gill slits. Although the metamorphic structure produces less suction, it allows for catching bigger prey because of a larger gape-size (biting rather than sucking). Our measures of feeding performances confirmed the data from natural populations, with each of the morphs preferentially eating their predicted prey. The particular use of micro-habitats by the two morphs is also in agreement with optimality models predicting predation in the more profitable patches. In the Alpine newt, paedomorphosis can be produced by two main processes: neoteny and progenesis. In some populations, the two morphs reached sexual maturity at the same age (neoteny); in other populations, sexual maturity was reached earlier by paedomorphs (progenesis). Progenesis was observed in unstable water habitats. Pond drying suppressed the possibility of late maturation, which is characteristic of a neotenic developmental pathway. On the other hand, the precocious sexual maturation of paedomorphs favoured the fast colonization of new habitats, owing to a high intrinsic rate of natural increase. Neoteny was typical of permanent waters with harsh constraints on growth. By forgoing metamorphosis, larvae also avoid the cost of changing of structure (decrease in body weight in our experiments). Progenetic paedomorphosis appears then as a major trait that can be selected due to the advantages of earlier maturation. The two morphs are sexually compatible; thus, metamorphs can "exchange" genes with paedomorphs at each generation. While the two morphs markedly differ in their secondary sexual characteristics, females did not show any preference related to these characteristics. The absence of sexual isolation between the morphs shows that they are not involved in a sympatric speciation process. The maintenance of the polymorphism is more advantageous than the formation of two isolated species. Paedomorphosis occurs in aquatic habitats where total drying can occur, and where the maintenance of facultative paedomorphosis is maintained by metamorphs that have paedomorphic genes but do not (permanently) express them. In such habitats, the sexual isolation of the two morphs would lead to the extinction of paedomorphosis in the event of pond drying or similar catastrophe. Because the environment can modify the ontogenetic pathway, paedomorphosis in the Alpine newt can be considered a polyphenism. Indeed, restricting the amount of water or food available induces paedomorphs to metamorphose. The marking of individual paedomorphs in a natural population proved that metamorphosis also occurs in the field. However, salamander density and progressive drying of aquaria did not have any apparent effect on paedomorph metamorphosis. When the possibility of a short migration across dry land was given, paedomorphs moved towards an available water basin and maintained their larval somatic characters during the migrations. By being able to migrate on land towards permanent water, paedomorphs are able to retain a feeding morphology that favors them in microhabitats where plankton is abundant. Facultative paedomorphosis in the Alpine newt allows populations to cope with environmental variability, and is adaptive in allowing precocious maturation or a larger use of resources in spatially heterogeneous environments. Thus, it is not surprising that paedomorphosis can evolve in such dissimilar environments as lowland temporary ponds and highland deep lakes. In such places, paedomorphosis appears to be the best solution as long as fish predation is relaxed. The introduction of fish throughout Europe is thus a serious problem, and has resulted in the extinction of several large paedomorphic populations. If this trend is not stopped rapidly, paedomorphosis in the Alpine newt - and in other species - will belong to the past. [less ▲]

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See detailRésultats check-up par check-up et corrélations entre eux
Leclercq, Dieudonné ULg; Georges, François ULg; Dupont, Chantal ULg et al

in Leclercq, Dieudonné (Ed.) Diagnostic cognitif et métacognitif au seuil de l'université : le projet Mohican menée par les 9 universités de la Communauté française Wallonie-Bruxelles (2003)

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See detailCellular Uptake Of Antennapedia Penetratin Peptides Is A Two-Step Process In Which Phase Transfer Precedes A Tryptophan-Dependent Translocation
Dom, G.; Shaw-Jackson, C.; Matis, C. et al

in Nucleic Acids Research (2003), 31(2), 556-61

Several homeodomains and homeodomain-containing proteins enter live cells through a receptor- and energy-independent mechanism. Translocation through biological membranes is conferred by the third alpha ... [more ▼]

Several homeodomains and homeodomain-containing proteins enter live cells through a receptor- and energy-independent mechanism. Translocation through biological membranes is conferred by the third alpha-helix of the homeodomain, also known as Penetratin. Biophysical studies demonstrate that entry of Penetratin into cells requires its binding to surface lipids but that binding and translocation are differentially affected by modifications of some physico-chemical properties of the peptide, like helical amphipathicity or net charge. This suggests that the plasma membrane lipid composition affects the internalization of Penetratin and that internalization requires both lipid binding and other specific properties. Using a phase transfer assay, it is shown that negatively charged lipids promote the transfer of Penetratin from a hydrophilic into a hydrophobic environment, probably through charge neutralization. Accordingly, transfer into a hydrophobic milieu can also be obtained in the absence of negatively charged lipids, by the addition of DNA oligonucleotides. Strikingly, phase transfer by charge neutralization was also observed with a variant peptide of same charge and hydrophobicity in which the tryptophan at position 6 was replaced by a phenylalanine. However, Penetratin, but not its mutant version, is internalized by live cells. This underscores that charge neutralization and phase transfer represent only a first step in the internalization process and that further crossing of a biological membrane necessitates the critical tryptophan residue at position 6. [less ▲]

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See detailDysregulation of inflammation
Bureau, Fabrice ULg; Lekeux, Pierre ULg

in Hoffman, A.; Robinson, N. E.; Wade, J. F. (Eds.) Proceedings of a Workshop on “Inflammatory Airway Disease: Defining the Syndrome”, Havemeyer Foundation Monograph Series No. 9 (2003)

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See detailIterating transducers in the large
Boigelot, Bernard ULg; Legay, A.; Wolper, Pierre ULg

in Lecture Notes in Computer Science (2003), 2725

Checking infinite-state systems is frequently done by encoding infinite sets of states as regular languages. Computing such a regular representation of, say, the reachable set of states of a system ... [more ▼]

Checking infinite-state systems is frequently done by encoding infinite sets of states as regular languages. Computing such a regular representation of, say, the reachable set of states of a system requires acceleration techniques that can finitely compute the effect of an unbounded number of transitions. Among the acceleration techniques that have been proposed, one finds both specific and generic techniques. Specific techniques exploit the particular type of system being analyzed, e.g. a system manipulating queues or integers, whereas generic techniques only assume that the transition relation is represented by a finite-state transducer, which has to be iterated. In this paper, we investigate the possibility of using generic techniques in cases where only specific techniques have been exploited so far. Finding that existing generic techniques are often not applicable in cases easily handled by specific techniques, we have developed a new approach to iterating transducers. This new approach builds on earlier work, but exploits a number of new conceptual and algorithmic ideas, often induced with the help of experiments, that give it a broad scope, as well as good performance. [less ▲]

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See detailCell Handling, Membrane-Binding Properties, And Membrane-Penetration Modeling Approaches Of Pivampicillin And Phthalimidomethylampicillin, Two Basic Esters Of Ampicillin, In Comparison With Chloroquine And Azithromycin
Chanteux, H.; Paternotte, I.; Mingeot-Leclercq, Mp. et al

in Pharmaceutical Research (2003), 20(4), 624-31

PURPOSE: The purpose of this work was to examine and understand the cellular pharmacokinetics of two basic esters of ampicillin, pivaloyloxymethyl (PIVA) and phthalimidomethyl (PIMA), in comparison with ... [more ▼]

PURPOSE: The purpose of this work was to examine and understand the cellular pharmacokinetics of two basic esters of ampicillin, pivaloyloxymethyl (PIVA) and phthalimidomethyl (PIMA), in comparison with lysosomotropic drugs (chloroquine, azithromycin). METHODS: Cell culture studies (J774 macrophages) were undertaken to study uptake and release kinetics and to assess the influence of concentration, pH, proton ionophore (monensin), and MRP and P-gp inhibitors (probenecid, gemfibrozil, cyclosporin A, GF 120918). Equilibrium dialysis with liposomes were performed to directly asses the extent of drug binding to bilayers. Conformational analysis modeling of the drug penetration in bilayers was conducted to rationalize the experimental observations. RESULTS: PIVA and PIMA showed properties in almost complete contrast with those of chloroquine and azithromycin, i.e., fast apparent accumulation and fast release at 4 degrees C as well as at 37 degrees C, saturation of uptake (apparent Kd 40 microM), no influence of monensin, MRP, or P-gp inhibitors; tight binding to liposomes (Kd approx. 40 microM); and sharp increase in calculated free energy when forced in the hydrophobic domain. CONCLUSIONS: Although they are weak organic bases, PIVA and PIMA show none of the properties of lysosomotropic agents. We hypothesize that they remain locked onto the pericellular membrane and may never penetrate cells as such in significant amounts. [less ▲]

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See detailGuidelines for clinical studies assessing the efficacy of drugs for the management of acute low back pain
Devogelaer, J. P.; Dreiser, R. L.; Abadie, Eric ULg et al

in Clinical and Experimental Rheumatology (2003), 21(6, NOV-DEC), 691-694

In this paper we propose guidelines for clinical trials aimed at assessing the efficacy of drugs for acute non-specific low back pain (LBP) with or without radicular pain, preliminary to their approval ... [more ▼]

In this paper we propose guidelines for clinical trials aimed at assessing the efficacy of drugs for acute non-specific low back pain (LBP) with or without radicular pain, preliminary to their approval and registration. To this end, consensus statements were obtained from a group of experts in the fields of rheumatology, clinical medicine, public health and epidemiology. EBM resources were systematically used as references. [less ▲]

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See detailModélisation 3D d’un groupe de pieux pour le pont-canal de Houdeng
Trevisan, Stefano; Li, Xian Ling; Collin, Frédéric ULg et al

in Revue Française de Géotechnique (2003), 105

A satisfactory prediction of the settlements of hyperstatic structures is becoming more and more important in their design and construction. In this paper, the problems related to the behaviour of a group ... [more ▼]

A satisfactory prediction of the settlements of hyperstatic structures is becoming more and more important in their design and construction. In this paper, the problems related to the behaviour of a group of piles and to the quality of the drilled piles of the canal-bridge of Houdeng (Belgium) are analysed in a non conventional fashion, based on a finite element analysis, thanks to sufficient experimental data. The influence of an imperfectly cleaned excavation bottom and of the destructuration of the bottom rocks caused by the drilling of the piles is investigated. A particular attention is also given to the behaviour of a group of piles. [less ▲]

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See detailDevenir médecin en République démocratique du Congo. La trajectoire socioprofessionnelle des diplômés en médecine de l'Université de Lubumbashi
Rubbers, Benjamin ULg

Book published by L'Harmattan, collection 'Cahiers africains' (2003)

Why and how one becomes a doctor in the Congo? While the economic situation has worsened since their entry at the university, how doctors who graduated at the end of the 1990s experienced their first job ... [more ▼]

Why and how one becomes a doctor in the Congo? While the economic situation has worsened since their entry at the university, how doctors who graduated at the end of the 1990s experienced their first job? To answer these questions, this book follows the career of young Congolese doctors from school to their present work. [less ▲]

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See detailThe Nucleon-Nucleon Problem in Quark Models
Stancu, Floarea ULg

in Few-Body Systems (2003), 14

In the first part we summarize the status of the nucleon-nucleon (NN) problem in the context of Hamiltonian based constituent quark models and present results for the $\ell = 0$ phase shifts obtained from ... [more ▼]

In the first part we summarize the status of the nucleon-nucleon (NN) problem in the context of Hamiltonian based constituent quark models and present results for the $\ell = 0$ phase shifts obtained from the Goldstone-boson exchange model by applying the resonating group method. The second part deals with the construction of local shallow and deep equivalent potentials based on a Superymmetric Quantum Mechanics approach. [less ▲]

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See detailFrom the germinal cells to the newborn animal: The transmission of genes and life through the generations
Drion, Pierre ULg; Szenci, Otto; Ectors, Fabien ULg et al

in Acta Veterinaria Hungarica (2003), 51(3), 371-384

The technology of reproduction progressed considerably during the last decade, leading to a certain availability of in vitro methods for fertilisation, oocyte maturation and embryo culture. The most ... [more ▼]

The technology of reproduction progressed considerably during the last decade, leading to a certain availability of in vitro methods for fertilisation, oocyte maturation and embryo culture. The most spectacular manipulations are cloning and transgenesis. This review focuses on the early appearance of germinal cell precursors and the long-standing fate of gametes in mammals. The evident complexity and long-term programming of events in gametes and early embryos explain part of the difficulties encountered during the development of in vitro and in vivo methods such as multiple Ovulation and embryo transfer (MOET), oestrus synchronisation, ovulation induction, superovulation, in vitro maturation and fertilisation, cryopreservation, transgenesis, nuclear transfer and cloning) and the occurrence of unexpected alterations of development, e.g. embryonic or fetal mortality, large-weight newborn syndrome and other dysregulations ill imprinting or DNA transmission. [less ▲]

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See detailComment je traite ... les troubles de la magnésémie
Guillaume, Thierry; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2003), 58(7-8), 465-467

Because symptoms associated with hypomagnesia are highly aspecific, this ionic abnormality is rarely searched for although it could be present in as much as 20 % of the population. The mode of correction ... [more ▼]

Because symptoms associated with hypomagnesia are highly aspecific, this ionic abnormality is rarely searched for although it could be present in as much as 20 % of the population. The mode of correction (oral or intravenous) depends on the etiology, severity and clinical consequences of hypomagnesemia. Significant hypermagnesemia only occurs in the presence of renal insufficiency and/or acute excess administration, mainly by the intravenous route. If interruption of administration does not suffice, renal dialysis might become necessary to quickly correct the magnesemium serum levels. [less ▲]

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See detailL'application dans le temps de la peine de travail
Jacobs, Ann ULg

in Revue de Droit Pénal et de Criminologie (2003)

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