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See detailChanges in function of iron-loaded alveolar macrophages after in vivo administration of desferrioxamine and/or chloroquine.
Legssyer, Rachida; Josse, Claire ULg; Piette, Jacques ULg et al

in Journal of Inorganic Biochemistry (2003), 94(1-2), 36-42

Both desferrioxamine (DFO) and chloroquine can significantly reduce hepatic iron in experimental animals with iron overload by chelating iron from the low-molecular-weight pool or decreasing iron uptake ... [more ▼]

Both desferrioxamine (DFO) and chloroquine can significantly reduce hepatic iron in experimental animals with iron overload by chelating iron from the low-molecular-weight pool or decreasing iron uptake by the transferrin-transferrin receptor cycle, respectively. However, no previous studies have investigated whether combination therapy of these two drugs would further decrease the tissue iron overload as well as iron-induced toxicity. Chloroquine administration, 15 mg/kg, 5x/week, to rats during the iron loading regime, 10 mg/kg, 3x/week for 4 weeks, significantly decreased both hepatic (54%) and macrophage iron content (24%). However when administered in combination with desferrioxamine, 10 mg/kg, 3x/week for 2 weeks at the cessation of iron loading, no further reduction of hepatic iron content was noted while the iron content of the macrophages significantly increased, possibly indicating the flux of ferrioxamine through these cells. Further studies are warranted to investigate the speciation of iron within these macrophages. Macrophages isolated from chloroquine-treated iron loaded rats showed a reduction in latent NFkappaB activation and a significant increase in lipopolysaccharide-stimulated nitrite release by comparison to these parameters in iron loaded macrophages. Co-administration of chloroquine and desferrioxamine normalised the latent activity of NFkappaB to that of control macrophages as well as increasing LPS-stimulated NO release towards control values. However, DFO alone did not have any significant effect upon either of these parameters. Such results may have important relevance for the reduced immune function of iron loaded macrophages isolated from thalassaemia patients receiving chelation therapy and their propensity to increased infection. [less ▲]

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See detailGuide des travaux pratiques de Physiologie végétale
Périlleux, Claire ULg

Learning material (2003)

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See detailDes profils de motivation pour la lecture en 6e primaire : une approche différenciée
Schillings, Patricia ULg

in Caractères (2003), 10(1), 13-21

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See detailThe family systems approach to treating families of persons with brain injury: a potential collaboration between family therapist and brain injury professional
Laroi, Frank ULg

in Brain Injury (2003), 17

Although brain injury may have a great impact on the family as a whole, family reactions are not adequately addressed in rehabilitative programmes. When they are, treatment tends to be approached from a ... [more ▼]

Although brain injury may have a great impact on the family as a whole, family reactions are not adequately addressed in rehabilitative programmes. When they are, treatment tends to be approached from a family education and support perspective and not from a family therapy perspective. The aim of the following paper is to illustrate the important role that a family systems approach can play in treating families of individuals with brain injury. In particular, clinical examples taken from the literature will be presented that illustrate how family roles can be modified as a consequence of a brain injury, and the importance of re-establishing or re-distributing these roles. It will be argued that an intimate collaboration between family therapist and brain injury professional is essential, and that the ideal professional make-up of clinicians working with families of persons with brain injury are those well-versed in both brain injury rehabilitation and family therapy. [less ▲]

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See detailLarval development of Myzostoma cirriferum (Myzostomida)
Eeckhaut, I.; Fievez, Laurence ULg; Muller, M. C.

in Journal of Morphology (2003), 258

The larval development of Myzostoma cirriferum is described by means of SEM, TEM, and cLSM. It is similar to that of other myzostomids and includes three stages: the protrochophore, the trochophore, and ... [more ▼]

The larval development of Myzostoma cirriferum is described by means of SEM, TEM, and cLSM. It is similar to that of other myzostomids and includes three stages: the protrochophore, the trochophore, and the metatrochophore. The protrochophore is a ball-shaped larva present in culture from 18-48 h after egg laying. It has no internal organs and its body is made of three cell types: covering cells and ciliated cells that are external and surrounded by a cuticle, and resting cells that fill the blastocoel. The trochophore is a pear-shaped larva that develops 20-72 h after egg laying; the body includes the same three cell types as the previous stage. The metatrochophore is a pear-shaped larva that develops between 40 h and 14 days and is characterized by the presence of two bundles of four chaetae. When fully developed, the metatrochophore has a digestive system (made of a pharynx, an esophagus, and a blind digestive pouch), two pairs of protonephridia, and a nervous system composed of a supraesophageal ganglion, circumesophageal connectives, and dorsal and ventral nerves. Metamorphosis generally occurs 7 days after egg laying. At that time, the metatrochophore loses its chaetae and becomes pleated ventrally. This ultrastructural analysis suggests that chaetae and the five ventral longitudinal nerve cords of M. cirriferum metatrochophores are homologous structures to those observed in some polychaete trochophores. Coupled with recent phylogenetic analyses, where the Myzostomida are placed outside the Annelida, homologies between myzostomid and polychaete larvae support the view that a trochophore appeared early during the spiralian evolution [less ▲]

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See detailThe alder populations of Europe
Claessens, Hugues ULg

in Gibbs, John; Van Dijk, Cees; Webber, Joan (Eds.) Phytophthora disease of alder in Europe (2003)

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See detailL'application dans le temps de la peine de travail
Jacobs, Ann ULg

in Revue de Droit Pénal et de Criminologie (2003)

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See detailL’Histoire par allusion
Denis, Benoît ULg

in Traces. Travaux du Centre d'Études Georges Simenon (2003), (14), 95-109

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See detailEffect of low-dose perindopril/indapamide on albuminuria in diabetes: preterax in albuminuria regression: PREMIER.
Mogensen, Carl Erik; Viberti, Giancarlo; Halimi, Serge et al

in Hypertension (2003), 41(5), 1063-71

Microalbuminuria in diabetes is a risk factor for early death and an indicator for aggressive blood pressure (BP) lowering. We compared a combination of 2 mg perindopril/0.625 mg indapamide with enalapril ... [more ▼]

Microalbuminuria in diabetes is a risk factor for early death and an indicator for aggressive blood pressure (BP) lowering. We compared a combination of 2 mg perindopril/0.625 mg indapamide with enalapril monotherapy on albumin excretion rate (AER) in patients with type 2 diabetes, albuminuria, and hypertension in a 12-month, randomized, double-blind, parallel-group international multicenter study. Four hundred eighty-one patients with type 2 diabetes and hypertension (systolic BP > or =140 mm Hg, <180 mm Hg, diastolic BP <110 mm Hg) were randomly assigned (age 59+/-9 years, 77% previously treated for hypertension). Results from 457 patients (intention-to-treat analysis) were available. After a 4-week placebo period, patients with albuminuria >20 and <500 microg/min were randomly assigned to a combination of 2 mg perindopril/0.625 mg indapamide or to 10 mg daily enalapril. After week 12, doses were adjusted on the basis of BP to a maximum of 8 mg perindopril/2.5 mg indapamide or 40 mg enalapril. The main outcome measures were overnight AER and supine BP. Both treatments reduced BP. Perindopril/indapamide treatment resulted in a statistically significant higher fall in both BP (-3.0 [95% CI -5.6, -0.4], P=0.012; systolic BP -1.5 [95% CI -3.0, -0.1] diastolic BP P=0.019) and AER -42% (95% CI -50%, -33%) versus -27% (95% CI -37%, -16%) with enalapril. The greater AER reduction remained significant after adjustment for mean BP. Adverse events were similar in the 2 groups. Thus, first-line treatment with low-dose combination perindopril/indapamide induces a greater decrease in albuminuria than enalapril, partially independent of BP reduction. A BP-independent effect of the combination may increase renal protection. [less ▲]

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See detailPurificazione delle proteine associate alla gestazione (PAG) nella bufala (Bubalus bubalis): risultati preliminari.
Barbato, O.; Melo de Sousa, Noelita ULg; Malfatti, A. et al

in Atti 2o Congresso Nazionale sull’Allevamento del Bufalo (2003)

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See detailGeological map of the Rogaland anorthosite province – Scale 1:75000
Marker, Mogens; Schiellerup, Henrik; Meyer, Gürli B. et al

in Duchesne, Jean-Clair; Korneliussen, Are (Eds.) Ilmenite deposits and their geological environment. With special reference to the Rogaland Anorthosite Province (2003)

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See detailPlacental proteins secreted in maternal circulation: useful indicators for both pregnancy diagnosis and embryonic mortality in bovine species
Moreira da Silva, F.; Melo de Sousa, Noelita ULg; Figueiredo, J. R. et al

in Revista Portuguesa de Zootecnia (2003), 10(1), 99-121

During the last decades, several research groups developed investigations in order to characterize proteins or glycoproteins synthesized by ruminant placenta. As result of these investigations, a large ... [more ▼]

During the last decades, several research groups developed investigations in order to characterize proteins or glycoproteins synthesized by ruminant placenta. As result of these investigations, a large family of pregnancy-associated glycoproteins was identified in bovine ovine and caprine placenta. By using molecular biology techniques, it was demonstrated that they are members of the aspartic proteinase superfamily, in which they co-exist with pepsinogens, renin, cathepsin D and E, etc. Due to their secretion in large amounts by the trophoblastic binucleated cells, bovine PAGs are detectable in maternal circulation soon after implantation. In the present work, in addition to the physiological and biochemical characterization of bovine PAGs, it will be showed how the measurement of PAG concentrations in maternal blood is useful for both pregnancy confirmation and follow-up of the fetus-placental well-being. Available information related to other placental proteins will be also discussed. [less ▲]

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See detailConlin V3 Optimizer: User and Installation Guide
Fleury, Claude ULg

Report (2003)

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See detailDu texte de circonstance au recueil de Situations. L’économie de l’écriture engagée chez Jean-Paul Sartre
Denis, Benoît ULg

in Langlet, Irène (Ed.) Le Recueil littéraire. Pratiques et théorie d’une forme (2003)

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See detailChromomycose autochtone chez une patiente immunodéprimée.
Quatresooz, Pascale ULg; Dethier, F.; Pierard, Gérald ULg

in Dermatologie Actualité (2003), 74

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See detailSensitivity analysis on ultimate strength of aluminium stiffened panels
Rigo, Philippe ULg; Sarghiuta, B.; Estefen, S. et al

in Marine Structures (2003)

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See detailConvection de Bénard-Marangoni en régime oscillant
Dondlinger, Mireille; Dauby, Pierre ULg

in Proceedings du 16ème Congrès français de mécanique, Nice, 1-5 septembre 2003 (2003)

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See detailÉlaboration d'une base de données en vue de l'informatisation du catalogue de la cartothèque de l'Unité de documentation des Sciences de la Terre de l'Université de Liège
Borsus, Olivier ULg

Master's dissertation (2003)

Ce mémoire est destiné à l'Unité de Documentation (U.D.) des Sciences de la Terre de l'Université de Liège et consiste en l'élaboration d'une base de données pour le catalogue de son fonds cartographique ... [more ▼]

Ce mémoire est destiné à l'Unité de Documentation (U.D.) des Sciences de la Terre de l'Université de Liège et consiste en l'élaboration d'une base de données pour le catalogue de son fonds cartographique. En effet, l'interface LIBER utilisée à l'Université ne répond pas entièrement aux attentes de l'U.D en terme de critères de recherche spécifiques aux documents cartographiques. Par conséquent il était nécessaire de réaliser une interface conviviale et pratique pour la recherche et la saisie des références de ces cartes. Le logiciel utilisé est FileMaker Pro 5. Pour faciliter l'utilisation de cette base de données, un thésaurus reprenant tous les pays du monde a été créé. A cette fin, les difficultés dues aux changements de noms régionaux et nationaux résultant des évolutions historiques et politiques au fil du temps ont fait l'objet d'une attention particulière. [less ▲]

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