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See detailThe treatment of sporadic versus MEN1-related pituitary adenomas.
Beckers, Albert ULg; Betea, Daniela ULg; Valdes Socin, Hernan Gonzalo ULg et al

in Journal of Internal Medicine (2003), 253(6), 599-605

The treatment of pituitary tumours strongly depends on their clinical presentation. In general, the treatment aims are reducing tumour volume and/or decreasing hormone hypersecretion. It relies on single ... [more ▼]

The treatment of pituitary tumours strongly depends on their clinical presentation. In general, the treatment aims are reducing tumour volume and/or decreasing hormone hypersecretion. It relies on single or a combination of three different methods: surgery, medication and radiotherapy. The rationale for deciding the treatment are many but include the aggressiveness of the tumour. The aetiologies of sporadic pituitary adenomas are not fully understood. However, several causes have been identified resulting in specific familial phenotypes like multiple endocrine neoplasia type I (MEN1). MEN1 is related to mutations in the MEN1 gene, a tumour suppressor gene localized on chromosome 11q13 and which encodes menin, a 610 amino acid protein. During the last years, an evidence progressively emerged that MEN1-related adenomas were more aggressive and less responsive to therapy than their sporadic counterparts. In this article, we review the differences between sporadic and MEN1-related adenomas and suggest specific ways of treatment and follow-up for MEN1-related tumours. [less ▲]

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See detailUrban use of VHR images on Bukavu (Democratic Republic of Congo)
Binard, Marc ULg; De Man, J.; Séba, G. et al

in Proceedings of the Second Workshop of the EARSeL Special Interest Group on Remote Sensing for Developing Countries, Bonn, Germany September 18-20, 2002. EARSeL: Paris, France. (2003)

The main purpose of this study was to show potential uses of very high resolution (VHR) image in an urban analysis of Bukavu in the Democratic Republic of Congo. As for many of the Third-World cities ... [more ▼]

The main purpose of this study was to show potential uses of very high resolution (VHR) image in an urban analysis of Bukavu in the Democratic Republic of Congo. As for many of the Third-World cities, Bukavu grew up during the last decades and available topographical information on Bukavu dates back to the middle of the twentieth century. This lack of updated information can be compensated by an appropriate use of VHR images. In this study, IKONOS image recorded on the 14th February 2001 was used. Image registration are highly dependant on accurate Digital Elevation Models (DEM), these last ones are also useful in urban analyses. The range between the minimum and maximum altitudes observed in the image was more than 500 meters. Furthermore, the viewing inclination angle is more than 28 degrees. In this case, orthorectification is mandatory for correcting relief displacements. Nevertheless, the lack of good Ground Control Points (GPS’s) on the old topographic maps and the failure to collect field verification data in Bukavu explains the remaining global 2D RMSE of 10 meters. For easier image interpretation, multispectral (4m) and panchromatic (1m) images were fused together by means of the LMVM algorithm. Depending on the object, the Computer Aided Photo Interpretation (CAPI) uses or does not use the near infrared information (true or false colour composite). For a more detailed interpretation about the city morphology we draped the 1m multispectral fused image over the 1m resolution DEM grid. The Built-up Area Index (BAI) computed on the urban mask obtained by CAPI and classification of the vegetation, was compared with the 1954 situation interpreted from topographic maps. The present city shows higher BAI values and in the same time the centre of the city has clearly shifted southward. Statistical analyses are also done on built-up versus slope data. The lack of good GCP’s and the use of DEM produced inaccurate orthorectification which was not adequate for topographical features extraction. Nevertheless the present extensions of Bukavu built-up areas are more than the double of those observed at the beginning of the last half century. New constructions are located on steeper slopes where landslides are frequents. More features could be extracted from the Ikonos image if good GPS measurements were made and if verification by the city authorities was possible. Some practical applications of this study could involve determining better location of new Bukavu extensions. [less ▲]

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See detailOn the use of control surface excitation in flutter testing
Wright, Jan R; Wong, Jerry; Cooper, Jonathan E et al

in Proceedings of the Institution of Mechanical Engineers - Part G - Journal of Aerospace Engineering (2003), 217(6), 317-332

Flutter testing is aimed at demonstrating that the aircraft flight envelope is flutter free. Response measurements from deliberate excitation of the structure are used to identify and track frequency and ... [more ▼]

Flutter testing is aimed at demonstrating that the aircraft flight envelope is flutter free. Response measurements from deliberate excitation of the structure are used to identify and track frequency and damping values against velocity. In this paper, the common approach of using a flight control surface to provide the excitation is examined using a mathematical model of a wing and control surface whose rotation is restrained by a simple actuator. In particular, it is shown that it is essential to use the demand signal to the actuator as a reference signal for data processing. Use of the actuator force (or strain) or control angle (or actuator displacement) as a reference signal is bad practice because these signals contain response information. It may also be dangerous in that the onset of flutter may not be seen in the test results. [less ▲]

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See detailNombres et jeux enfantins
Lempereur, Françoise ULg

in Enquêtes du Musée de la Vie Wallonne (2003), XX

Children learn to count at school and also by singing and playing traditional games. This paper goes through the traditional Walloon repertory and shows how it fits the childish rhythmics defined by ... [more ▼]

Children learn to count at school and also by singing and playing traditional games. This paper goes through the traditional Walloon repertory and shows how it fits the childish rhythmics defined by ethnomusicologist Constantin Brailoiu [less ▲]

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See detailAcoustical communication of Przewalski horses (Equus przewalski Poliakov, 1881) in Hungary.
Dewasmes, J.; Woeger, F.; Huynen, Marie-Claude ULg et al

Poster (2003)

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See detailMonitoring sanitaire des ongulés sauvages
Linden, Annick ULg

Article for general public (2003)

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See detailPrévention primaire des maladies rénales et secondaire de l'insuffisance rénale
Krzesinski, Jean-Marie ULg; Rorive, Georges ULg

in Médi-Sphère (2003), 192

Il est apparu important de rèsumer les points capitaux à respecter lors de tout contact avec un patient, d'une part pour le proteger du développement de la maladie rénale (si possible) et pour freiner l ... [more ▼]

Il est apparu important de rèsumer les points capitaux à respecter lors de tout contact avec un patient, d'une part pour le proteger du développement de la maladie rénale (si possible) et pour freiner l'évolution de celle-ci une fois constituée d'autre part, l'objectif étant alors d'éviter l'insuffisance rénale sévère, stade où l'intervention du médecin n'est plus que symptomatique. Généralement fortuite, l'insuffisance rénale gagne à être diagnostiquée précocement. L'intervention du néphrologue sera également d'autant plus efficace que rapide. [less ▲]

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See detailWild edible mushrooms from a Zambezian woodland area (Copperbelt Province, Zambia).
Bourdeaux, Quentin; Buyck, B.; Malaisse, François ULg et al

in Geo-Eco-Trop (2003), 27(1-2), 33-44

Dans de nombreux pays d'Afrique tropicale, la consommation de champignons sauvages constitue un appoint alimentaire non négligeable pour les populations locales. La présente étude fut menée dans la ... [more ▼]

Dans de nombreux pays d'Afrique tropicale, la consommation de champignons sauvages constitue un appoint alimentaire non négligeable pour les populations locales. La présente étude fut menée dans la Copperbelt Province( Zambie), un territoire situé en Région zambézienne. La récolte de sporophores et les enquêtes participatives menées auprès des villageois ont permis de dresser une liste de 47 tâxons de champignons comestibles. [less ▲]

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See detailMycoplasma bovis : synthèse des connaissances actuelles
Thomas, Anne; Mainil, Jacques ULg; Linden, Annick ULg

in Annales de Médecine Vétérinaire (2003), 147(1, FEB-MAR), 23-39

Mycoplasmas frequently infect cattle. Amongst them, M. Bovis is the most pathogenic species in countries free from contagious bovine pleuropneumonia because it is responsible for bronchopneumonia ... [more ▼]

Mycoplasmas frequently infect cattle. Amongst them, M. Bovis is the most pathogenic species in countries free from contagious bovine pleuropneumonia because it is responsible for bronchopneumonia, arthritis and mastitis, and is thus associated with strong economic losses. Several studies have shown the frequency of M. bovis in Europe and the spread of antibiotic-resistant strains. Considering the absence of vaccine in Europe, it is essential to understand this bacteria in order to control the infection in cattle. In this context, this paper aims at summarizing the current knowledge about M. bovis. [less ▲]

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See detailExtase en ontnuchtering. Guido Gezelle en Herman de Coninck beyond discourse
Spinoy, Erik ULg

in Gezelliana (2003), (1), 45-71

A comparison of the literary views of the 19th-century romantic poet Guido Gezelle and his 20th-century counterpart Guido Gezelle reveal a series of striking resemblances, which are discussed in this ... [more ▼]

A comparison of the literary views of the 19th-century romantic poet Guido Gezelle and his 20th-century counterpart Guido Gezelle reveal a series of striking resemblances, which are discussed in this article. [less ▲]

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See detailL'évaluation de la maîtrise d'une langue, maternelle ou étrangère
Defays, Jean-Marc ULg; Maréchal, Marielle ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2003), 15-16

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See detailThe Nucleon-Nucleon Problem in Quark Models
Stancu, Floarea ULg

in Few-Body Systems (2003), 14

In the first part we summarize the status of the nucleon-nucleon (NN) problem in the context of Hamiltonian based constituent quark models and present results for the $\ell = 0$ phase shifts obtained from ... [more ▼]

In the first part we summarize the status of the nucleon-nucleon (NN) problem in the context of Hamiltonian based constituent quark models and present results for the $\ell = 0$ phase shifts obtained from the Goldstone-boson exchange model by applying the resonating group method. The second part deals with the construction of local shallow and deep equivalent potentials based on a Superymmetric Quantum Mechanics approach. [less ▲]

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See detailGéographie des services et des commerces
Merenne-Schoumaker, Bernadette ULg

Book published by PUR (Presses universitaires de Rennes) (2003)

Nouvelle édition d'un manuel édité chez Nathan (Paris) en 1996 sous le titre "La localisation des services" et qui sera réédité en 2008 par les Presses universitaires de Rennes

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See detailKarsts en roches cristallines silicatées non carbonatées. Cas dans des gneiss : la grotte de Mfoula, Sud Cameroun
Willems, Luc ULg; Pouclet, André; Vicat, Jean-Paul

in Actes des Journées Européennes de l'AFK 2003 (2003)

Since the Seventies, a séries of phenomena developed in non carbonated silicated rocks question the traditional vision of karst. The term of karst is used in the meaning of "any feature of the classical ... [more ▼]

Since the Seventies, a séries of phenomena developed in non carbonated silicated rocks question the traditional vision of karst. The term of karst is used in the meaning of "any feature of the classical karst morphology (caves, sink-holes, lapiaz...) where dissolution plays the main genetic action and this in any kind of rocks". The cave of Guéssédoundou illustrâtes a karst in métagabbros. It opens at the top of a small hill, in a dépression twenty meters long and three to four meters deep. The walls of this dépression are subvertical and the bottom is partially occupied by angular pluridecimetric blocks. The cave is opened on several meters in the southern side of the dépression and is prolonged in the form of too narrow conduits to be explore. The bedrock is a metagabbro with fine grains, slightly weathered, crossed by decimetric quartzose veins. Gabbroïc texture is preserved, as well as part of magmatic plagioclases. The remainder is transformed into a mixture of white feldspar and clinozoisite. Pyroxene are pseudomorphosed in actinote and chlorite. The site dépression was created along a N 10° shear zone where rocks suffered important fracturation and fluid transfers, as shown by its silification and ferruginisation.. Moreover, a East-West schistosity, former to shearing, structures the gabbro. The présence of angular blocks of variable size and the absence of human activity trace on the site show that the dépression was formed naturally by collapse of the roof of a more vast cavity whose current cave would be the visible residual prolongation. The absence of flow traces and mechanical abrasion means that this cavity is due only to chemical érosion . At the cave entry and on the subvertical walls of the dépression were formed by alveoli a few centimètres to a few décimètres in diameter. Thèse alveoli of wall are known in other lithologies, in particular in limestones. The absence of salts within the rock draws aside a formation by sait weathering. The smooth aspect and non fractured walls of the cells cannot resuit from a corrosion to a fracturing node. The closed aspect of the dépression and the absence of flow trace eliminate the assumptions from formation by water swirls or eolisation. The genesis of the cave must be earlier to the installation of a weathering cover since the rock is little deteriorated and the alveoli are not developed on a quite particular level which would correspond to a précise pedogenic horizon. Only a generalized dissolution of the métagabbros, in relation to a slow solution circulation, being carried out with the favour of the fracturing plans of the shearing zone makes it possible to explain the formation of the alveoli. The inversion of relief results from a weaker érosion of the rocks made more résistant to this place by the quartz seam mainstay and by the ferruginisation along the shearing zone. In the other hand, the crushed rocks, become porous, drained the infiltrations of meteoric water, facilitating the dissolution processes. The study of the site of Guéssédoundou shows that karstic phenomena can also exist in silico-aluminous formations of crystalline rocks [less ▲]

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See detailAbsolute and relative quantification : beyond mutually exclusive word classes.
Brems, Lieselotte ULg; Davidse, Kristin

in Belgian Journal of English Language and Literatures. New Series (2003), 1

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See detailApport des volumes de Fresnel en tomographie sismique
Sage, Sandrine; Grandjean, Gilles; Verly, Jacques ULg

Conference (2003)

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See detailCell cycle duration at the time of maternal zygotic transition for in vitro produced bovine embryos: effect of oxygen tension and transcription inhibition.
Lequarré, Anne-Sophie ULg; Marchandise, J.; Massip, A. et al

in Biology of Reproduction (2003), 69(5), 1707-13

Early embryonic cleavages are mostly regulated by maternal components then control of development progressively depends on newly synthesized zygotic products. The timing of the first cleavages is a way to ... [more ▼]

Early embryonic cleavages are mostly regulated by maternal components then control of development progressively depends on newly synthesized zygotic products. The timing of the first cleavages is a way to assess embryo quality. The goal of this study was to evaluate the duration of the fourth cell cycle, at the time of maternal-to-zygotic transition (MZT) in in vitro-produced bovine embryos by means of cinematographic analysis. We found that 75% of the embryos displayed a long fourth cycle (43.5 +/- 5.4 h) whereas the remaining embryos had a very short fourth cell cycle (8.9 +/- 2.9 h). Both groups did not differ in cleavage rhythm up to the eight-cell stage and timing of cavitation and blastocyst expansion was identical. However, embryos with a short fourth cell cycle had a better blastocyst rate than embryos with a long cycle (59% versus 38%, P < 0.01). Total cell number, inner cell mass (ICM):total cell ratio, and hatching rate were identical for blastocysts produced from embryos with either a long or a short fourth cell cycle. In a second experiment, we showed that increasing the oxygen tension, from 5% to 20%, decreased the percentage of embryos with a short fourth cell cycle, from 25% to 11% (P < 0.01), indicating that suboptimal culture conditions can influence the length of this cycle. Finally, we investigated whether fourth cell cycle duration could be influenced by transcription inhibition. With alpha-amanitin added at 18 h postinsemination (HPI), cleavage was reduced (66% versus 79%) and, at 70 HPI, the 9- to 16-cell rate increased (50% versus 25%) concomitantly with a 5- to 8-cell rate decrease (16% versus 47%). A similar pattern was observed when the drug was added at 6 HPI or 42 HPI but not at 0 HPI. Cinematographic analysis revealed that alpha-amanitin increased the first cell cycle duration whereas the second and third cell cycles were not affected. With the drug, one third of the embryos could develop up to the 9- to 16-cell stage and they all had a short fourth cell cycle (11.2 +/- 3.7 h) with a good synchrony of cleavage between blastomeres. These results suggest that duration of the fourth cell cycle of bovine embryo, during the MZT, is under a zygotic transcriptional control that can be affected by oxidative conditions. [less ▲]

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See detailIntramyocardial synthesis of pro- and anti-inflammatory cytokines in infants with congenital cardiac defects.
Qing, Ma; Schumacher, Kathrin; Heise, Ruth et al

in Journal of the American College of Cardiology (2003), 41(12), 2266-74

OBJECTIVES: We sought to test the hypothesis that cytokines would be expressed in the myocardium of infants with congenital cardiac defects and to identify the signaling pathways involved. BACKGROUND ... [more ▼]

OBJECTIVES: We sought to test the hypothesis that cytokines would be expressed in the myocardium of infants with congenital cardiac defects and to identify the signaling pathways involved. BACKGROUND: Mechanical stress upregulates pro-inflammatory cytokines in the myocardium. METHODS: Fifteen infants with tetralogy of Fallot (TOF) (n = 7) or with ventricular septal defects (VSDs) (n = 8) were investigated. Concentrations of pro- and anti-inflammatory cytokines and of the inducible nitric oxide synthase (iNOS) were measured by enzyme-linked immunosorbent assay and/or Western blotting in the right ventricular myocardium taken during cardiac surgery. Activation of the nuclear factor-kappa-B (NF-kappa-B) and p38 mitogen-activated protein kinase (MAPK) pathways was assessed by electrophoretic mobility shift assay with supershift and/or Western blotting, respectively. RESULTS: The pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha, interleukin (IL)-1-beta, and IL-6 and the anti-inflammatory cytokine IL-10 were detected in the myocardium of all patients. Concentrations of the pro-inflammatory cytokines and also of phosphorylated p38 MAPK were higher in patients with TOF than in those with VSD and correlated with the degree of pressure overload of the right ventricle. Levels of phosphorylated I-kappa-B-alpha, iNOS, and IL-10 were similar in patients with TOF and in those with VSD. CONCLUSIONS: Our results show intramyocardial synthesis of pro-inflammatory cytokines in infants with congenital cardiac defects. This is associated with activation of both the NF-kappa-B and p38 MAPK pathways. The latter could be particularly important for the transduction of mechanical signals in the infant's myocardium. Synthesis of IL-10 indicates an intramyocardial anti-inflammatory potential in this age group. [less ▲]

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