References of "2003"
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See detailAnti-inflammatory effect of natural proanthocyanidins: pharmacological evaluation on in vivo models.
Garbacki, Nancy ULg; Tits, Monique ULg; Damas, Jacques ULg

in Pflügers Archiv : European Journal of Physiology (2003), 446

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See detailRegulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells.
Mottet, Denis ULg; Dumont, Valery; Deccache, Yann et al

in Journal of Biological Chemistry (2003), 278(33), 31277-85

Hypoxia initiates an intracellular signaling pathway leading to the activation of the transcription factor hypoxia-inducible factor-1 (HIF-1). HIF-1 activity is regulated through different mechanisms ... [more ▼]

Hypoxia initiates an intracellular signaling pathway leading to the activation of the transcription factor hypoxia-inducible factor-1 (HIF-1). HIF-1 activity is regulated through different mechanisms involving stabilization of HIF-1alpha, phosphorylations, modifications of redox conditions, and interactions with coactivators. However, it appears that some of these steps can be cell type-specific. Among them, the involvement of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway in the regulation of HIF-1 by hypoxia remains controversial. Here, we investigated the activation state of PI3K/Akt/glycogen synthase kinase 3beta (GSK3beta) in HepG2 cells. Increasing incubation times in hypoxia dramatically decreased both the phosphorylation of Akt and the inhibiting phosphorylation of GSK3beta. The PI3K/Akt pathway was necessary for HIF-1alpha stabilization early during hypoxia. Indeed, its inhibition was sufficient to decrease HIF-1alpha protein level after 5-h incubation in hypoxia. However, longer exposure (16 h) in hypoxia resulted in a decreased HIF-1alpha protein level compared with early exposure (5 h). At that time, Akt was no longer present or active, which resulted in a decrease in the inhibiting phosphorylation of GSK3beta on Ser-9 and hence in an increased GSK3beta activity. GSK3 inhibition reverted the effect of prolonged hypoxia on HIF-1alpha protein level; more stabilized HIF-1alpha was observed as well as increased HIF-1 transcriptional activity. Thus, a prolonged hypoxia activates GSK3beta, which results in decreased HIF-1alpha accumulation. In conclusion, hypoxia induced a biphasic effect on HIF-1alpha stabilization with accumulation in early hypoxia, which depends on an active PI3K/Akt pathway and an inactive GSK3beta, whereas prolonged hypoxia results in the inactivation of Akt and activation of GSK3beta, which then down-regulates the HIF-1 activity through down-regulation of HIF-1alpha accumulation. [less ▲]

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See detailChapitre 6: Le syndrome tumoral hypophysaire de l'acromégalie
Brue, Thierry; Dufour, Henry; VALDES SOCIN, Hernan Gonzalo ULg et al

in Chanson, Philippe (Ed.) Visages de l'acromégalie (2003)

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See detailL'euthanasie en Belgique et aux Pays-Bas
Leleu, Yves-Henri ULg

in Revue Trimestrielle des Droits de l'Homme (2003)

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See detailDu texte de circonstance au recueil de Situations. L’économie de l’écriture engagée chez Jean-Paul Sartre
Denis, Benoît ULg

in Langlet, Irène (Ed.) Le Recueil littéraire. Pratiques et théorie d’une forme (2003)

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See detailPour lire Pédigrée
Dumortier, Jean-Louis ULg

in Dossiers L (Littérature française de Belgique (2003), 64(4),

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See detailİzmir Gezisi: Antoine Galland'ın Bir Elyazması (1678)
Galland, Antoine; Bauden, Frédéric ULg; Üyepazarcı, Erol

Book published by İzmir Büyükşehir Belediyesi Kültür Yayını (2003)

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See detailA Framework For Humanoid Control and Intelligence
Platt, Robert; Brock, Oliver; Fagg, Andrew et al

in Proceedings of the IEEE International Conference on Humanoid Robots (2003)

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See detail3-Isopropylamino-7-nitro-1,4,2-benzodithiazine 1,1-dioxide
Dupont, L.; Somers, F.; De Tullio, Pascal ULg et al

in Acta Crystallographica (2003)

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See detailA survey of proposals for an alternative group communication service
El-Sayed, A.; Roca, V.; Mathy, Laurent ULg

in IEEE Network (2003), 17(1), 46--51

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See detailPharmacological evaluation of the novel thromboxane modulator BM-567 (II/II). Effects of BM-567 on osteogenic sarcoma-cell-induced platelet aggregation
De Leval, X.; Benoit, V.; Delarge, J. et al

in Prostaglandins, Leukotrienes, and Essential Fatty Acids (2003)

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See detailLa Convention de Bruxelles
Boularbah, Hakim ULg; Nuyts, Arnaud; Watte, N.

in Journal des Tribunaux Droit Européen (2003)

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See detailLa responsabilité des fondateurs en cas de capital insuffisant
Caprasse, Olivier ULg

in La constitution de sociétés et la phase de démarrage d'entreprises (2003)

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See detailThe value of serologic markers in indeterminate colitis: A prospective follow-up study - Reply
Joossens, S.; Van Steen, Kristel ULg; Vermeire, S. V. et al

in Gastroenterology (2003), 125(3), 999-1000

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See detailBehavioral characterization of acetaldehyde in C57BL/6J mice: Locomotor, hypnotic and ataxic effects
Quertemont, Etienne ULg; Tambour, Sophie ULg; Tirelli, Ezio ULg

in Behavioural Pharmacology (2003), 14(Suppl. 1), 69-69

Acetaldehyde, the first ethanol metabolite, was recently suggested to play a major role in many behavioral effects of ethanol. However, no studies have directly investigated the behavioral effects of ... [more ▼]

Acetaldehyde, the first ethanol metabolite, was recently suggested to play a major role in many behavioral effects of ethanol. However, no studies have directly investigated the behavioral effects of acetaldehyde after acute administration. Therefore, the aim of the present study was to characterize the locomotor, hypnotic and ataxic effects of acetaldehyde in C57BL/6J mice. Various acetaldehyde doses (0-300 mg/kg) were injected intraperitoneally and their effects were investigated with several classical behavioral tests. The locomotor effects of acetaldehyde were measured in standard activity boxes. In addition, the loss of righting reflex was used to assess the hypnotic effects of acetaldehyde. Finally, the ataxic effects of acetaldehyde were studied with the horizontal wire test. The results show that acetaldehyde induced a significant hypolocomotor effect at 170 mg/kg and higher doses. In addition, the hypnotic effects of acetaldehyde were evidenced by a loss of righting reflex in doses between 170 and 300 mg/kg. However, the locomotor and hypnotic effects of acetaldehyde were very brief relative to what is observed after ethanol administration. After 170 mg/kg acetaldehyde, normal activity was recovered in less than 30 minutes and the loss of righting reflex lasted only an average of 6.14 ± 1.29 minutes after the administration of 300 mg/kg acetaldehyde, the highest testable dose before lethality. Ataxic effects were observed with lower doses that did not significantly affect locomotor activity. These results show that acetaldehyde, like ethanol, possesses sedative, hypnotic and ataxic properties and therefore indicate that the first product of ethanol metabolism might be involved in these ethanol effects. [less ▲]

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See detailL'image du mois. Hématome hépatique après une réanimation cardio-pulmonaire
Delanaye, Pierre ULg; De Fooz, Geoffroy; NCHIMI LONGANG, Alain ULg et al

in Revue Médicale de Liège (2003), 58(7-8, Jul-Aug), 463-464

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