References of "2003"
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See detailDéveloppements récents en pychopédagogie et en linguistique appliquée pour la didactique des langues étrangères et secondes
Defays, Jean-Marc ULg

in Collès, Luc; Dufays, Jean-Louis; Maeder, C. (Eds.) Enseigner le français, l'espagnol et l'italien. Les langues romanes à l'heure des compétences (2003)

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See detailEffet de la pression partielle en oxygène sur le métabolisme des chondrocytes bovins en culture
Burton, S; Mathy-Hartet, M; Dupont, G et al

in Revue du Rhumatisme (2003), 70

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See detailBelgium's immigration Policy
Martiniello, Marco ULg

in International Migration Review (2003), 37(1), 225-232

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See detailA current challenge: processing of bistatic STAP signals
Verly, Jacques ULg

Scientific conference (2003)

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See detailFinancement du terrorisme
Dantinne, Michaël ULg; Seron, Vincent ULg

in Revue de Droit Pénal et de Criminologie (2003), (6), 840-875

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See detailAn Integrated Software for Scantling Optimization and Least Production Cost
Rigo, Philippe ULg

in Ship Technology Research = Schiffstechnik (2003)

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See detailLes protéines de choc thermique (heat shock proteins). II Les protéines de choc thermique (heat shock proteins). II. Hsp70, biomarqueur, bioprotecteur.
Wirth, Delphine; Gustin, Pascal ULg; Drion, Pierre ULg et al

in Annales de Médecine Vétérinaire (2003), 147(2), 127-144

The exposure of any organism to high temperature induces rapid and transient cellular overexpression of specific proteins, the heat shock proteins (Hsps). This response, called heat shock response, was ... [more ▼]

The exposure of any organism to high temperature induces rapid and transient cellular overexpression of specific proteins, the heat shock proteins (Hsps). This response, called heat shock response, was initially discovered in Drosophila. The genes hsps were among the first eukaryotic genes to be cloned and whose regulation, which involves activation of heat shock factor (HSF), was elucidated. More recently, study of Hsp functions, particularly Hsp70, started. Their protective role, related to their molecular chaperon function, was inferred from experiments showing that Hsp70 expression, induced by a first stress, results in a cellular tolerance to second stress. Better understanding of the heat shock response had led to the development of two search fields on Hsp70 expression : (1) its use as biomarker of cellular stress and (2) the exploitation of its cytoprotective functions against various insults. This review includes historic of the research on the heat shock response, description of regulation mechanism of Hsp70 expression, and the interesting perspectives allocated to Hsp70 as biomarker and therapeutic tool. ----------- L’exposition de tout organisme à des températures élevées induit l'expression cellulaire rapide et transitoire de protéines spécifiques, les protéines de choc thermique (Hsps pour " heat shock proteins "). Cette réponse des cellules au choc thermique ou " heat shock response " a été initialement découverte chez la drosophile. Les gènes hsps furent parmi les premiers gènes eucaryotes à être clonés et utilisés comme paradigme dans l'étude des mécanismes de régulation transcriptionnelle faisant intervenir l'activation d'un ou plusieurs " heat shock factors" (HSFs). C'est plus récemment que l'étude des fonctions des Hsps, particulièrement Hsp70, a débuté. Le rôle protecteur de celle-ci, lié à sa fonction de " chaperon " protéique, a été déduit d'expériences montrant que l'induction de l'expression de Hsp70 lors d'un stress était associée au développement d'une tolérance cellulaire vis-à-vis d'un stress ultérieur. En plus d'un intérêt fondamental pour la compréhension de la "réponse au choc thermique", deux axes de recherche appliquée se sont développés visant à investiguer la possibilité d'utiliser l'expression de Hsp70 comme biomarqueur de souffrance cellulaire d'une part et, d'autre part, d'exploiter ses fonctions comme moyen de protection des cellules contre divers types d'agressions. Cette revue décrit l'historique des découvertes sur la " réponse au choc thermique ", le mécanisme régulant l'expression de Hsp70 ainsi que les perspectives intéressantes s'ouvrant à l'utilisation de l'expression de Hsp70 en tant que biomarqueur et outil thérapeutique. [less ▲]

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See detailHeavy metals in marine mammals
Das, Krishna ULg; Debacker, Virginie ULg; Pillet, Stéphane et al

in Vos, Joseph G.; Bossart, Gregory D.; Fournier, Michel (Eds.) et al Toxicology of marine mammals (2003)

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See detailNumerical mdeling of hydro-mechanical fracture behaviour
Guiducci, Chiara; Collin, Frédéric ULg; Radu, Jean-Pol ULg et al

Conference (2003)

A numerical approach for modeling coupled Hydro-Mechanical fracture behavior in 2D is presented in this paper. This approach accounts for the strong dependence of the flow characteristics on fracture ... [more ▼]

A numerical approach for modeling coupled Hydro-Mechanical fracture behavior in 2D is presented in this paper. This approach accounts for the strong dependence of the flow characteristics on fracture apertures and offers an anisotropic description of the flow propagation in the fracture. An interface finite element and a constitutive model are developed . In order to validate the applicability of the model to general geomechanic problems, 2D simulations were performed. Results show the good application of the mathematical model and the fundamental hydraulic role played by the fractures. [less ▲]

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See detailModule de garantie de transmission
Reinbold, Pierre; Martin, Sylvain ULg; Bonaventure, Olivier et al

in ARTHUR - Manuel d'informatisation des urgences (2003)

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See detailIlmenite deposits and their geological environment (with special reference to the Rogaland Anorthosite province, including a geological map at scale 1:75,000)
Duchesne, Jean-Clair ULg; Korneliussen, Are

Book published by NGU (2003)

The Rogaland Anorthosite Province comprises three major massif-type anorthosites, two smaller-sized anorthositic-leuconoritic bodies, as well as a large layered, dominantly noritic intrusion. A mangero ... [more ▼]

The Rogaland Anorthosite Province comprises three major massif-type anorthosites, two smaller-sized anorthositic-leuconoritic bodies, as well as a large layered, dominantly noritic intrusion. A mangero-noritic intrusion is found in the northeastern part of the province and major acidic intrusions are located to the far southeast. The Rogaland Anorthosite Province was emplaced into the Sveconorwegian orogenic belt of southwest Scandinavia at 931±3 Ma. Emplacement took place at around 5.5 kbar producing a thermal aureole with osumilite and pigeonite isograds and evidence for dehydration melting. The early history of the hosting terrane most likely dates back to Gothian or late Pre-Gothian times and contain evidence for numerous episodes of folding and deformation. Contact metamorphism was superimposed on a crustal volume, which had been exposed to Sveconorwegian granulite facies metamorphism between 1024 and 970 Ma. Deformation patterns, mineral compositional considerations and geothermobarometry imply that the Rogaland anorthosites crystallized along a P-T trajectory starting at 10-13 kbar, and were emplaced in a mushy state. The possibility that primitive jotunites may be parental to the andesine anorthosites have recently been substantiated, and experimental data show that these jotunites most likely formed by melting of gabbronoritic sources in the lower crust. The 230 km2 Bjerkreim-Sokndal Layered Intrusion also derive from jotunitic parents, and jotunites form a continuous liquid line of descent filling the gap between basic and acidic rocks in Rogaland. This intrusion contains a >7000 m thick layered cumulate sequence, consisting of virtually all the rock types belonging to the anorthosite kindred. The intrusion morphology, layering and compositional variation result from a variety of magma chamber processes, which are discussed in detail. The Rogaland Anorthosite Province also hosts numerous Fe-Ti oxide deposits of variable size, grade and composition. The oxide deposits have been divided into three basic types based on their oxide-phosphate association; type 1: ilmenite-only, type 2: ilmenite + magnetite and type 3: ilmenite + magnetite + apatite. This excursion guide provides detailed itineraries to most parts of the Rogaland Anorthosite Province, with in-depth descriptions of more than 40 key localities, The itineraries cover the various anorthosites, the Bjerkreim-Sokndal Layered Intrusion, jotunitic and acidic intrusions, the hosting metamorphic complex, as well as Fe-Ti oxide and sulfide deposits. [less ▲]

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See detailDiagnosis and monitoring of pregnancy in sheep: reality and perspectives
El Amiri, Bouchra; Karen, Aly; Cognié, Yves et al

in Productions Animales (2003), 16(2), 79-90

The present review aims at presenting different methods for pregnancy diagnosis. Since these methods are to be used in the herds, precocity, sensitivity, specificity, accuracy to predict pregnant and non ... [more ▼]

The present review aims at presenting different methods for pregnancy diagnosis. Since these methods are to be used in the herds, precocity, sensitivity, specificity, accuracy to predict pregnant and non-pregnant ewes, and the possibility to determine fetal numbers are carefully analysed. The progesterone assay is accurate as early as day 17th after fecundation; but the fertilization day must be precisely known. The pregnancy specific or associated glycoproteins (PSPB/PAG) assay is highly sensitive and specific at day 22 in blood and at day 32 in milk samples. However, this assay does not allow to predict the fetal number. The ultrasonography B-mode used on 30 days of gestation gives very good or excellent performance in terms of sensitivity and specificity depending on the practitioner. The method is also able to predict the real time fetal number. [less ▲]

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See detailCoherent states, wavelets and applications G24 - LLN
Antoine, J. P.; Bastin, Françoise ULg; De Mol, C. et al

in Group 24 : Physical and Mathematical Aspects of Symmetries (2003)

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See detailUse of the impulse oscillometry system for testing pulmonary function during methacholine bronchoprovocation in horses.
Van Erck, Emmanuelle ULg; Votion, Dominique ULg; Kirschvink, Nathalie et al

in American Journal of Veterinary Research (2003), 64(11), 1414-1420

OBJECTIVE: To compare sensitivity of the impulse oscillometry system (IOS) with that of the conventional reference technique (CRT; ie, esophageal balloon method) for pulmonary function testing in horses ... [more ▼]

OBJECTIVE: To compare sensitivity of the impulse oscillometry system (IOS) with that of the conventional reference technique (CRT; ie, esophageal balloon method) for pulmonary function testing in horses. ANIMALS: 10 horses (4 healthy; 6 with recurrent airway obstruction [heaves] in remission). PROCEDURE: Healthy horses (group-A horses) and heaves-affected horses (group-B horses) were housed in a controlled environment. At each step of a methacholine bronchoprovocation test, threshold concentration (TC(2SD); results in a 2-fold increase in SD of a value) and sensitivity index (SI) were determined for respiratory tract system resistance (R(rs)) and respiratory tract system reactance (X(rs)) at 5 to 20 Hz by use of IOS and for total pulmonary resistance (RL) and dynamic lung compliance (C(dyn)), by use of CRT. RESULTS: Bronchoconstriction resulted in an increase in R(rs) at 5 Hz (R(5Hz)) and a decrease in X(rs) at all frequencies. Most sensitive parameters were X(rs) at 5 Hz (X(5Hz)), R(5Hz), and R(5Hz):R(10Hz) ratio; RL and the provocation concentration of methacholine resulting in a 35% decrease in dynamic compliance (PC(35)C(dyn)) were significantly less sensitive than these IOS parameters. The TC(2SD) for X(rs) at 5 and 10 Hz was significantly lower in group-B horses, compared with group-A horses. The lowest TC(2SD) was obtained for X(5Hz) in group-B horses and R(5Hz) in group-A horses. CONCLUSIONS AND CLINICAL RELEVANCE: In contrast to CRT parameters, IOS parameters were significantly more sensitive for testing pulmonary function.The IOS provides a practical and noninvasive pulmonary function test that may be useful in assessing subclinical changes in horses. [less ▲]

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See detailInteraction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression.
Twizere, Jean-Claude ULg; Kruys, Veronique; Lefebvre, Laurent et al

in Journal of the National Cancer Institute (2003), 95(24), 1846-59

BACKGROUND: The Tax oncoproteins are transcriptional regulators of viral expression involved in pathogenesis induced by complex leukemogenic retroviruses (or delta-retroviruses, i.e., primate T-cell ... [more ▼]

BACKGROUND: The Tax oncoproteins are transcriptional regulators of viral expression involved in pathogenesis induced by complex leukemogenic retroviruses (or delta-retroviruses, i.e., primate T-cell leukemia viruses and bovine leukemia virus). To better understand the molecular pathways leading to cell transformation, we aimed to identify cellular proteins interacting with Tax. METHODS: We used a yeast two-hybrid system to identify interacting cellular proteins. Interactions between Tax and candidate interacting cellular proteins were confirmed by glutathione S-transferase (GST) pulldown assays, co-immunoprecipitation, and confocal microscopy. Functional interactions between Tax and one interacting protein, tristetraprolin (TTP), were assessed by analyzing the expression of tumor necrosis factor-alpha (TNF-alpha), which is regulated by TTP, in mammalian cells (HeLa, D17, HEK 293, and RAW 264.7) transiently transfected with combinations of intact and mutant Tax and TTP. RESULTS: We obtained seven interacting cellular proteins, of which one, TTP, was further characterized. Tax and TTP were found to interact specifically through their respective carboxyl-terminal domains. The proteins colocalized in the cytoplasm in a region surrounding the nucleus of HeLa cells. Furthermore, coexpression of Tax was associated with nuclear accumulation of TTP. TTP is an immediate-early protein that inhibits expression of TNF-alpha at the post-transcriptional level. Expression of Tax reverted this inhibition, both in transient transfection experiments and in stably transfected macrophage cell lines. CONCLUSION: Tax, through its interactions with the TTP repressor, indirectly increases TNF-alpha expression. This observation is of importance for the cell transformation process induced by leukemogenic retroviruses, because TNF-alpha overexpression plays a central role in pathogenesis. [less ▲]

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See detailLa motivation du refus de prononcer une peine de travail
Jacobs, Ann ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailBiostratigraphic correlation at the Late or/and Latest Famennian from Western, Central and Eastern European sections. State of the art.
Streel, Maurice ULg; Avkhimovitch, V.I.; Berkowski, B et al

in Newsletter. Subcommission on Devonian Stratigraphy (2003), 19

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See detailMultivariate and multidimensional analysis
Van Steen, Kristel ULg; Molenberghs, G.

in Wilson (Ed.) Biometrics (2003)

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See detailDes différences liées au sexe : pas si simple
Blondin, Christiane ULg; Lafontaine, Dominique ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2003), 15-16

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