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See detailRetreatment of hepatitis C non-responsive to interferon. A placebo controlled randomized trial of ribavirin monotherapy versus combination therapy with Ribavirin and Interferon in 121 patients in the Benelux [ISRCTN53821378]
Veldt, Bart J; Brouwer, Johannes T; Adler, Michael et al

in BMC Gastroenterology (2003), 3(1), 24

BACKGROUND: Evidence based medicine depends on unbiased selection of completed randomized controlled trials. For completeness it is important to publish all trials. This report describes the first large ... [more ▼]

BACKGROUND: Evidence based medicine depends on unbiased selection of completed randomized controlled trials. For completeness it is important to publish all trials. This report describes the first large randomised controlled trial where combination therapy was compared to placebo therapy and to ribavirin monotherapy, which has not been published until now. METHODS: One hundred and twenty one patients with chronic hepatitis C and elevated transaminases who did not respond to previous treatment with standard interferon monotherapy, were included from 16 centers in Belgium, the Netherlands and Luxembourg between 1992 and 1996. Patient poor-response characteristics were: genotype 1 (69%), HCV RNA above 2 x 10(6) copies/ml (55%) and cirrhosis (38%). Patients were randomized to 6 months combination therapy with interferon alpha-2b (3 MU tiw) and ribavirin (1000-1200 mg/day), 6 months ribavirin monotherapy (1000-1200 mg/day) or 6 months ribavirin placebo. The study was double blinded for the ribavirin/placebo component. One patient did not fit the entry criteria, and 3 did not start. All 117 patients who received at least one dose of treatment were included in the intention to treat analysis. RESULTS: At the end of treatment, HCV RNA was undetectable in 35% of patients on combination therapy and in none of the patients treated with ribavirin monotherapy or placebo. The sustained virological response rate at 6 months after therapy was 15% for patients treated with interferon and ribavirin.During the 6 months treatment period 13% of patients on interferon ribavirin combination therapy, 13% of patients on ribavirin monotherapy and 11% of patients on placebo withdrew due to side effects or noncompliance. At 24 weeks of treatment the mean Hb level was 85% of the baseline value, which means a mean decrease from 9.1 mmol/l to 7.8 mmol/l. The Hb levels at the end of treatment were not significantly different from patients treated with ribavirin monotherapy (p = 0.76). End of treatment WBC was significantly lower in patients treated with combination therapy, compared to ribavirin (p < 0.01) as well as for patients treated with ribavirin monotherapy compared to placebo (p < 0.01). DISCUSSION: This belated report on the only placebo controlled study of interferon ribavirin combination therapy in non responders to standard doses of interferon monotherapy documents the effectiveness, be it limited, of this approach as well as the dynamics of the effects on blood counts. [less ▲]

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See detailAn Integrated Software for Scantling Optimization and Least Production Cost
Rigo, Philippe ULg

in Ship Technology Research = Schiffstechnik (2003)

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See detailLiquidiation du régime matrimonial. Actualités de jurisprudence
Leleu, Yves-Henri ULg

in Leleu, Yves-Henri (Ed.) Actualités de droit familial. Le point en 2003 (2003)

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See detailExpression in an msb3msb4 yeast mutant of 2 human homologues of the yeast MSB3 MSB4 genes: RN-tre and Tre2 oncogene
Bizimungu, Christelle; Burny, Arsène; Portetelle, Daniel ULg et al

in Yeast (Chichester, England) (2003), 20(S1),

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See detailThe Sturtian 'snowball' glaciation: fire and ice
Godderis, Y.; Donnadieu, Y.; Nedelec, A. et al

in Earth And Planetary Science Letters (2003), 211(1-2), 1-12

The Sturtian 'snowball' glaciation (730 Ma) is contemporary with the dislocation of the Rodinia supercontinent. This dislocation is heralded and accompanied by intense magmatic events, including the onset ... [more ▼]

The Sturtian 'snowball' glaciation (730 Ma) is contemporary with the dislocation of the Rodinia supercontinent. This dislocation is heralded and accompanied by intense magmatic events, including the onset of large basaltic provinces between 825 and 755 Ma. Among these magmatic events, the most important one is the onset of a Laurentian magmatic province at 780 Ma around a latitude of 30degreesN. The presence of these fresh basaltic provinces increases the weatherability of the continental surfaces, resulting in an enhanced consumption of atmospheric CO2 through weathering, inducing a global long-term climatic cooling. Based on recent weathering laws for basaltic lithology and on climatic model results, we show that the weathering of a 6 x 10(6) km(2) basaltic province located within the equatorial region (where weathering of the province and consumption of CO2 are boosted by optimal climatic conditions) is sufficient to trigger a snowball glaciation, assuming a pre-perturbation PCO2 value of 280 ppmv. We show that the Laurentian magmatic province might be the main culprit for the initiation of the Sturtian 'snowball' glaciation, since the Laurentian magmatic province had drifted within the equatorial region by the time of the glaciation. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailRedefining the role of psr in beta-lactam resistance and cell autolysis of Enterococcus hirae.
Sapunaric, Frédéric ULg; Franssen, Christine; Stefanic, Patrick et al

in Journal of Bacteriology (2003), 185(20), 5925-35

The contribution of penicillin-binding protein 5 (PBP5) and the PBP5 synthesis repressor (Psr) to the beta-lactam resistance, growth, and cell autolysis of wild-type strain ATCC 9790 and resistant strain ... [more ▼]

The contribution of penicillin-binding protein 5 (PBP5) and the PBP5 synthesis repressor (Psr) to the beta-lactam resistance, growth, and cell autolysis of wild-type strain ATCC 9790 and resistant strain R40 of Enterococcus hirae was investigated by disruption or substitution of the corresponding pbp5 and psr genes by Campbell-type recombination. The resulting modifications were confirmed by hybridization and PCR. The low susceptibility of E. hirae to beta-lactams was confirmed to be largely dependent on the presence of PBP5. However, against all expectations, inactivation of psr in ATCC 9790 or complementation of R40 cells with psr did not modify the susceptibility to benzylpenicillin or the growth and cell autolysis rates. These results indicated that the psr gene does not seem to be involved in the regulation of PBP5 synthesis and consequently in beta-lactam resistance or in the regulation of cell autolysis in E. hirae. [less ▲]

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See detailNear real-time validation of GPS-TEC using ionosonde TEC at Dourbes
Warnant, René ULg; Nebdi, Hamid; Pottiaux, Eric

Report (2003)

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See detailDynamics of PCB transfer from mother to pup during lactation in UK grey seals Halichoerus grypus: differences in PCB profile between compartments of transfer and changes during the lactation period
Debier, Cathy; Pomeroy, Paddy P.; Dupont, Cédric et al

in Marine Ecology-Progress Series (2003), 247

The composition of the PCB mixture which is transferred from mother to pup in grey seals Halichoerus grypus throughout lactation was measured in the successive compartments of transfer: maternal blubber ... [more ▼]

The composition of the PCB mixture which is transferred from mother to pup in grey seals Halichoerus grypus throughout lactation was measured in the successive compartments of transfer: maternal blubber, maternal serum, milk and pup serum. Mother-pup pairs were captured regularly between birth and weaning on the Isle of May, Scotland. The PCB profiles of the different compartments of transfer consisted mainly of congeners 153, 138, 180, 187, 170 and 101, which made up 85% of the total PCB burden. Outer blubber contained higher relative concentrations (R-153) Of hepta-, octa-, and nona-chlorinated congeners (higher chlorinated congeners) than inner blubber, at both early (less than or equal to 5 d) and late (greater than or equal to 11 d) lactation. There was no change in the composition of the outer blubber layer between early and late lactation, while in the inner blubber, there was a slight increase in the R153 of higher chlorinated congeners at late lactation. In maternal serum, profiles changed towards having a higher proportion of higher chlorinated congeners as lactation progressed, but in milk, the PCB pattern stayed constant throughout lactation. Surprisingly, in pup serum profiles also changed towards higher R153 of higher chlorinated congeners at late lactation compared to early lactation, which was different to the pattern observed in milk. In all body compartments, higher proportions of higher chlorinated congeners were associated with higher concentrations of total PCBs. Maternal blubber and pup serum contained a higher R153 of higher chlorinated congeners than milk and, to a lesser extent, maternal serum. Thus biomagnification of the higher chlorinated congeners was recorded in pup serum. [less ▲]

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See detailUne étude d'adéquation : l'éveil aux langues dans le contexte de la Communauté française de Belgique
Mattar, C.; Blondin, Christiane ULg

in Blondin, Christiane (Ed.) S'ouvrir aux langues et aux cultures grâce à l'éveil aux langues (2003)

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See detailMechanisms underlying the toxicity of lactone aroma compounds towards the producing yeast cells
Aguedo, Mario ULg; Beney, L.; Waché, Y. et al

in Journal of Applied Microbiology (2003), 94(2), 258-265

Aims: To study the fundamental mechanisms of toxicity of the fruity aroma compound γ-decalactone, that lead to alterations in cell viability during its biotechnological production by yeast cells; Yarrowia ... [more ▼]

Aims: To study the fundamental mechanisms of toxicity of the fruity aroma compound γ-decalactone, that lead to alterations in cell viability during its biotechnological production by yeast cells; Yarrowia lipolytica that is able to produce high amounts of this metabolite was used here as a model. Methods and Results: Lactone concentrations above 150 mg l-1 inhibited cell growth, depolarized the living cells and increased membrane fluidity. Infrared spectroscopic measurements revealed that the introduction of the lactone into model phospholipid bilayers, decreased the phase transition temperature. Moreover, the H+-ATPase activity in membrane preparations was strongly affected by the presence of the lactone. On the other hand, only a slight decrease in the intracellular pH occurred. Conclusions: We propose that the toxic effects of γ-decalactone on yeast may be initially linked to a strong interaction of the compound with cell membrane lipids and components. Significance and Impact of the Study: These findings may enable the elaboration of strategies to improve yeast cell viability during the process of lactones bioproduction. [less ▲]

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See detailAssessment of the effect of small-scale TEC gradients on DPN-GPS applications using a system of colors
Warnant, René ULg; Lejeune, Sandrine; Pottiaux, Eric

Report (2003)

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See detailCompte rendu de l'ouvrage de S. Dawans : Le spectre de la honte
Cormann, Grégory ULg

in Archives de Philosophie (2003), 66(2), 340-342

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See detailModeling lactation curves and estimation of genetic parameters for first lactation test-day records of French Holstein cows.
Druet, Tom ULg; Jaffrezic, F.; Boichard, D. et al

in Journal of Dairy Science (2003), 86(7), 2480-90

Several functions were used to model the fixed part of the lactation curve and genetic parameters of milk test-day records to estimate using French Holstein data. Parametric curves (Legendre polynomials ... [more ▼]

Several functions were used to model the fixed part of the lactation curve and genetic parameters of milk test-day records to estimate using French Holstein data. Parametric curves (Legendre polynomials, Ali-Schaeffer curve, Wilmink curve), fixed classes curves (5-d classes), and regression splines were tested. The latter were appealing because they adjusted the data well, were relatively insensitive to outliers, were flexible, and resulted in smooth curves without requiring the estimation of a large number of parameters. Genetic parameters were estimated with an Average Information REML algorithm where the average information matrix and the first derivatives of the likelihood functions were pooled over 10 samples. This approach made it possible to handle larger data sets. The residual variance was modeled as a quadratic function of days in milk. Quartic Legendre polynomials were used to estimate (co)variances of random effects. The estimates were within the range of most other studies. The greatest genetic variance was in the middle of the lactation while residual and permanent environmental variances mostly decreased during the lactation. The resulting heritability ranged from 0.15 to 0.40. The genetic correlation between the extreme parts of the lactation was 0.35 but genetic correlations were higher than 0.90 for a large part of the lactation. The use of the pooling approach resulted in smaller standard errors for the genetic parameters when compared to those obtained with a single sample. [less ▲]

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See detailFinancement du terrorisme
Dantinne, Michaël ULg; Seron, Vincent ULg

in Revue de Droit Pénal et de Criminologie (2003), (6), 840-875

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See detailRecombinant human erythropoietin therapy is very effective after an autologous peripheral blood stem cell transplant when started soon after engraftment.
Baron, Frédéric ULg; Frere, Pascale ULg; Fillet, Georges ULg et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (2003), 9(15), 5566-72

PURPOSE: Previous trials of recombinant human erythropoietin (rHuEpo) therapy after autologous hematopoietic stem cell transplantation have administered very high doses of i.v. rHuEpo starting on day 1 ... [more ▼]

PURPOSE: Previous trials of recombinant human erythropoietin (rHuEpo) therapy after autologous hematopoietic stem cell transplantation have administered very high doses of i.v. rHuEpo starting on day 1 and continuing for 1-2 months until erythroid engraftment and have shown no benefit of rHuEpo therapy. We sought to establish a more effective use of rHuEpo in this setting. EXPERIMENTAL DESIGN: In this report, we show in a first cohort of 45 lymphoma or myeloma patients undergoing peripheral blood stem cell transplant (control group) that endogenous erythropoietin levels are high for the degree of anemia during the first 3 weeks after transplant but become adequate or slightly decreased thereafter. We thus enrolled 41 consecutive similar patients in a trial of rHuEpo therapy at a dose of 500 units/kg/week started on day 30 after the transplant. RESULTS: The 12-week probability of achieving hemoglobin (Hb) levels of 13 g/dl was 87% in rHuEpo-treated patients versus 14% in controls (P = 0.0001). Mean Hb levels were significantly higher in the rHuEpo group than in the control group from day 42 through day 150 after transplant (Ps of <0.05 to <0.001). Two of 41 patients in the rHuEpo group versus 12 of 45 patients in the control group had Hb levels of <9 g/dl between day 42 and day 100 after the transplant (P = 0.0078). CONCLUSIONS: Anemia after autologous peripheral blood stem cell transplant is exquisitely sensitive to rHuEpo when therapy is started soon after engraftment. This is the first convincing report showing that rHuEpo is effective in this setting. Our data set the stage for a more rational use of rHuEpo after autologous hematopoietic stem cell transplantation and should renew interest in erythropoietin therapy in this setting. Prospective, randomized trials should investigate the impact of rHuEpo therapy on transfusion requirements and quality of life. [less ▲]

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See detailA new Mars ionosphere/airglow Model between 60 and 500 km altitude
Witasse, Oliver; Blelly, P.; Lilensten, Jean et al

in Proceedings of the Workshop “Mars Atmosphere Modelling and Observations” (2003)

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See detailNumerical simulations of tissue ingrowth and differentiation around a loaded titanium implant in a bone chamber
Van Oosterwyck, Hans; Geris, Liesbet ULg; Vander Sloten, Jos et al

in Proceedings of the symposium on integrated systems in dental healthcare (2003)

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See detailDistinct T cell subsets and cytokine production in cultures derived from transformation zone and squamous intraepithelial lesion biopsies of the uterine cervix.
Jacobs, Nathalie ULg; Renard, Isabelle; Al-Saleh, Walid et al

in American Journal of Reproductive Immunology (2003), 49(1), 6-13

PROBLEM: The characterization of lymphocytes issued from squamous intraepithelial lesions (SIL) and from the transformation zone (TZ), where the majority of SIL occur, is important to understand the role ... [more ▼]

PROBLEM: The characterization of lymphocytes issued from squamous intraepithelial lesions (SIL) and from the transformation zone (TZ), where the majority of SIL occur, is important to understand the role of immunity in SIL development. METHOD OF STUDY: We compared lymphocyte populations of the TZ and SIL with those of normal exocervix, using a technique allowing for the isolation of lymphocytes, either from the epithelium or from the underlying stroma of small biopsies. RESULTS: The majority of cells derived from the epithelium of all biopsies were CD8+ T cells. Some SIL-derived cultures were characterized by an increased proportion of activated TCRgammadelta+. The production of the immunosuppressive cytokine IL10 was significantly higher in lymphocyte cultures from the normal TZ in comparison with the exocervix. A decreased percentage of effector T cells was observed in cultures derived from the stroma of normal TZ (TCRgammadelta+) or SIL (CD8+) in comparison with the exocervix. CONCLUSIONS: Our results suggest that a low proportion of effector T cells and IL10 production could contribute to the predisposition of the TZ to the development of SIL and to the progression of SIL to cervical cancer. [less ▲]

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