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See detailThe changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients.
Valdes Socin, Hernan Gonzalo ULg; Chanson, Philippe; Delemer, B. et al

in European Journal of Endocrinology (2003), 148(4), 433-442

OBJECTIVE: Our aim was to report the recent changes in diagnosis and management of TSH-secreting pituitary adenomas. METHODS: We retrieved 43 consecutive patients with TSH-secreting pituitary tumors (23 ... [more ▼]

OBJECTIVE: Our aim was to report the recent changes in diagnosis and management of TSH-secreting pituitary adenomas. METHODS: We retrieved 43 consecutive patients with TSH-secreting pituitary tumors (23 male and 20 female) among 4400 pituitary adenomas followed between 1976 and 2001 in six Belgian and French centers. RESULTS: TSH was elevated in 18/43 and alpha subunit in 13/32 patients. In patients with intact thyroid (n=30), mean free tri-iodothyronine was 13.1 pmol/l (range 3.5-23) and mean free thyroxine was 38.4 pmol/l (range 10.2-62.7). Hyperprolactinemia and acromegaly were associated in 9/43 and 8/43 cases. The number of associated hypersecretions was higher in macroadenomas than in microadenomas (Chi square = 11.2, P<0.01). Two women had sporadic multiple endocrine neoplasia type 1-associated syndrome. The proportion of microadenomas versus macroadenomas was 1/11 (period 1974-1986) and 8/32 (period 1987-2001). Bilateral petrosal sinus sampling, (111)In-pentreotide scintigraphy and ((11)C)-l-methionine positron emission tomography scan confirmed diagnosis in four questionable microadenomas. Macroadenomas with extrasellar extension (31 cases) had a tendency to be medially located. Medical treatment with somatostatin analogs was initiated as first-line treatment in 26 patients. TSH levels were reduced by more than 50% in 23/26 cases. A tumoral shrinkage of more than 20% was observed in 5/13 cases. Surgery was performed in 36 patients. After 1 year, 21 of them (58.3%) met the criteria of surgical favorable outcome. Pituitary radiotherapy (n=8) and somatostatin analogs allowed normalization in cases not cured by surgery. CONCLUSION: Ultrasensitive methods for TSH measurement led to an earlier recognition of TSH-secreting pituitary tumors. In this series, we observed that TSH-secreting pituitary tumors are today more frequently found at the stage of microadenomas, medially located, without associated hypersecretions and needing new exploration methods as compared with older series. This changing spectrum in the presentation of TSH-secreting pituitary tumors and the excellent response to somatostatin analogs has been accompanied by an improvement in the prognosis of the disease. [less ▲]

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See detailRequiem pour le monde ancien
Denis, Benoît ULg

in Swennen, René (Ed.) Les Trois Frères (2003)

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See detailDerivation of the 1.0-0.9 Ga ferro-potassic A-type granitoids of southern Norway by extreme differentiation from basic magmas
Vander Auwera, Jacqueline ULg; Bogaerts, Michel; Liégeois, Jean-Paul ULg et al

in Precambrian Research (2003), 124(2-4), 107-148

Major and trace elements, Sr and Nd isotopic data as well as mineral compositions are presented for a selection of the 1.0 - 0.9 ferro-potassic A-type granitoids (Bessefjellet, Rustfjellet ... [more ▼]

Major and trace elements, Sr and Nd isotopic data as well as mineral compositions are presented for a selection of the 1.0 - 0.9 ferro-potassic A-type granitoids (Bessefjellet, Rustfjellet, Verhuskjerringi, Valle, Holum, Svöfjell, Handeland-Tveit, Åseral, Lyngdal gabbronorites) that occur close to the Mandal-Ustaoset Line of southern Norway. These hornblende biotite granitoids (HBG) define an extensive differentiation trend ranging from gabbronorites (50 wt % SiO2) to granites (77 wt % SiO2). This trend is interpreted as resulting from extreme fractional crystallization of several basaltic magma batches with similar major and trace elements compositions. At 930 Ma, the HBG suite displays a narrower range in ISr (0.7027 - 0.7056) than in Nd(t) (+1.97 down to -4.90) suggesting some assimilation of a Rb-depleted lower crust (AFC process) or/and source variability. An age of 929 ± 47 Ma is given by a Rb-Sr isochron on the Holum granite (Sri = 0.7046 ±0.0006, MSWD = 1.7). Geothermobarometers indicate a low pressure of emplacement (1.3-2.7 kbar) and an oxygen fugacity close to NNO. High liquidus temperatures are given by the apatite saturation thermometer (1005°C to 1054 °C) and are in agreement with results from other studies. The basaltic parent magmas of the HBG suite are partial melts of an hydrous mafic, potassic source lying either in the lithospheric upper mantle or in the mafic lower crust derived from it. This contrasts with the 930 Ma anorthosite-mangerite-charnockite suite (AMC) of the Rogaland Province for which a depleted lower crustal anhydrous gabbronoritic source has been indicated. The present data imply the penecontemporaneous melting of two contrasting sources in southern Norway. The source duality could result from an increasing degree of metamorphism (amphibolite to granulite) from East to West, an horizontal stratification of the lower crust or from the stratification of the lithosphere (melting of the lower crust or upper mantle). It may also indicate that the AMC and HBG suites formed in two distinct crustal segments. The linear alignment of the HBG suite along the Mandal-Ustaoset shear zone suggests that a linear uprise of the asthenosphere, following a lithospheric delamination under this structure, could be the vector of the mantle heat. [less ▲]

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See detailUse of atropine to inhibit vagally mediated baroreceptor reflex in horses undergoing dobutamine stress test
Sandersen, Charlotte ULg; Detilleux, Johann ULg; Delguste, Catherine ULg et al

in Pflügers Archiv : European Journal of Physiology (2003), 446(5), 4

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See detailMesure de l'effet de l'hyperimmunisation pour le contrôle de la rhinotrachéite infectieuse bovine dans les troupeaux laitiers en Belgique : analyse de survie
Dispas, Marc; Kerkhofs, Pierre; Thiry, Etienne ULg

in Epidémiologie et Santé Animale (2003), 44

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See detailRésultats check-up par check-up et corrélations entre eux
Leclercq, Dieudonné ULg; Georges, François ULg; Dupont, Chantal ULg et al

in Leclercq, Dieudonné (Ed.) Diagnostic cognitif et métacognitif au seuil de l'université : le projet Mohican menée par les 9 universités de la Communauté française Wallonie-Bruxelles (2003)

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See detailFungal lectin, XCL, is internalized via clathrin-dependent endocytosis and facilitates uptake of other molecules.
Francis, Frédéric ULg; Marty-Detraves, Claire; Poincloux, Renaud et al

in European Journal of Cell Biology (2003), 82(10), 515-22

The lectin isolated from Xerocomus chrysenteron (XCL) displays a toxic activity towards insects. In order to assess its possible mode of action and to gather useful data for its potential use in insect ... [more ▼]

The lectin isolated from Xerocomus chrysenteron (XCL) displays a toxic activity towards insects. In order to assess its possible mode of action and to gather useful data for its potential use in insect-resistant transgenic plants, we investigated the effects of XCL at the cellular level. Immunofluorescence microscopy studies revealed that XCL is rapidly internalized into small endocytic vesicles that further coalesce in the perinuclear region. We show that XCL is endocytosed by the clathrin-dependent pathway, and is delivered to late endosome/lysosome compartments. The internalization of XCL seems to be general since it occurs in different cell types such as insect (SF9) or mammalian (NIH-3T3 and Hela) cell lines. In the presence of XCL, the uptake of GFP and BSA is greatly enhanced, demonstrating that XCL facilitates endocytosis. Thus, XCL could serve as a delivery agent to facilitate the endocytosis of proteins that do not enter the cell alone. [less ▲]

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See detailTime-dependent behaviour of oil reservoir chalk: A multiphase approach
De Gennaro, Vincenzo; Delage, Pierre; Cui, Yu Jun et al

in Soils and Foundations (2003), 43(4),

In the North Sea Ekofisk oilfield, oil is located in a 300 m thick layer of porous chalk (n = 40-50%) at a 3000 m depth. After the initial phase of depletion an enhanced oil recovery procedure was carried ... [more ▼]

In the North Sea Ekofisk oilfield, oil is located in a 300 m thick layer of porous chalk (n = 40-50%) at a 3000 m depth. After the initial phase of depletion an enhanced oil recovery procedure was carried out by injecting sea water (waterflooding). An unexpected consequence of this waterflooding has been the occurrence of a seafloor subsidence, corresponding up to now to a decrease of the seafloor level of approximately 10 m. It is now well recognised that hydro-mechanical coupling involving multiphase fluid interactions (oil and water) is determinant for the interpretation of the phenomenological aspects associated with the chalk compaction and the related subsidence observed in the North Sea oilfields (Ekofisk reservoir) when water flooded. The subsidence due to waterflooding is interpreted as a collapse phenomenon due to suction decrease, typical of loose and low plasticity unsaturated soils when wetted under load. On the other hand, time-dependent stress-strain behaviour of geomaterials is one of the major concerns in soil mechanics and, in effect, subsidence includes creep effects. A multiphase approach, including creep effects under controlled suction levels, is proposed in this paper; the preliminary results of this study are presented and discussed. Attention will be focused at first on the theoretical approach, supplying the essential elements for the work, and on the interpretation of the experimental results. This will provide secondly the base for formulation and validation of the constitutive law proposed for the description of the time-dependent mechanical behaviour of the chalk. [less ▲]

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See detailEncurvada lateral de vigas metalicas sujeitas a acçao do fogo: uma nova proposta de calculo simples complementar ao EC3
Vila Real, P.; Lopes, N.; Simoes da Silva, L. et al

in Lamas; Calado; Ferreira (Eds.) et al Proceedings of the Congresso de Construçao Metallica e Mista (2003)

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See detailDéveloppement de la compétence orale en anglais par l'optimisation des stratégies de communication
Simons, Germain ULg

in Actes du 2e congrès des chercheurs en éducation. L'Ecole, dans quel(s) sens ? (2003)

Cette communication retrace les grandes étapes d'un programme de recherche collaborative, menée entre 2000 et 2002, portant sur l'optimisation de la compétence orale en anglais/langue étrangère dans l ... [more ▼]

Cette communication retrace les grandes étapes d'un programme de recherche collaborative, menée entre 2000 et 2002, portant sur l'optimisation de la compétence orale en anglais/langue étrangère dans l'enseignement secondaire de la Communauté française de Belgique. Après avoir décrit le contexte général de cette recherche-action, nous proposons une définition opérationnelle du concept "stratégie de communication" et précisons les questions de recherche. Puis, nous décrivons le schéma expérimental et mentionnons les principaux résultats obtenus. Enfin, nous concluons avec des perpectives quant à la poursuite de cette recherche, entre autres, l'élaboration d'un outil de formation et de diffusion, qui était en cours d'élaboration au moment où nous avons présenté cette communication. [less ▲]

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See detailMarocains de Belgique : du travailleur immigré au citoyen transnational
Bousetta, Hassan ULg; Martiniello, Marco ULg

in Hommes & Migrations (2003), 1242(Mars-Avril), 94-106

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See detailLa formation continue en Belgique : profils des participants et esquisses de parcours : exploitation de l'Enquête sur les Forces de Travail 2000
Baye, Ariane ULg; Mainguet, Christine ULg; Demeuse, Marc ULg et al

in Guyot, J. (Ed.) La formation professionnelle continue : l'individu au coeur des dispositifs (2003)

La diffusion de la notion de 'formation tout au long de la vie' dans les discours politiques amène à un renouvellement des interrogations sur la formation continue des adultes. Les outils de mesure se ... [more ▼]

La diffusion de la notion de 'formation tout au long de la vie' dans les discours politiques amène à un renouvellement des interrogations sur la formation continue des adultes. Les outils de mesure se sont progressivement adaptés à cette nouvelle donne; c'est le cas de l'Enquête sur les Forces de Travail (EFT) d'Eurostat mise en oeuvre en Belgique par l'INS. Grâce à l'exploitation inédite de certaines variables de l'enquête, nous avons voulu approcher les dynamiques individuelles qui sous-tendent la participation à diverses formes de formation continue. Ces dynamiques peuvent en effet être abordées sous l'angle de l'accès, de l'investissement en temps et des objectifs poursuivis par les personnes, mais également par le biais des résultats obtenus, par exemple, en termes d'amélioration du niveau de qualification. En amont et en aval du processus de formation, motivations initiales et situations sur le marché du travail peuvent aussi permettre de mieux cerner le fonctionnement de la formation continue. [less ▲]

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See detailNumerical modelling of metal forming - current practice and advanced applications
Cescotto, Serge ULg; Duchene, Laurent ULg; Pascon, Frédéric ULg et al

in Iu, V. P.; Lamas, L. N.; Li, Y. P. (Eds.) et al Computational Methods in Engineering and Science, lu et al. (eds), Proceedings of the 9th International Conference of enhancement and Promotion of Computing Methods for Engineering and Science (2003)

This paper first summarizes the current possibilities and the perspectives of effective modeling of metal forming processes. Practical considerations on manpower requirement and data availability are ... [more ▼]

This paper first summarizes the current possibilities and the perspectives of effective modeling of metal forming processes. Practical considerations on manpower requirement and data availability are included in the discussion. Then, two examples of advanced applications are presented: the micro-macro approach for the modeling of sheet metal forming and the modeling of continuous casting. [less ▲]

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See detailComparison of change in bone resorption and bone mineral density with once-weekly alendronate and daily risedronate: a randomised, placebo-controlled study
Hosking, D.; Adami, S.; Felsenberg, D. et al

in Current Medical Research & Opinion (2003), 19(5), 383-394

Objective: To compare the effects of alendronate (ALN) 70 mg once weekly (OW) and risedronate (RIS) 5 mg daily between-meal dosing on biochemical markers of bone turnover and bone mineral density (BMD) in ... [more ▼]

Objective: To compare the effects of alendronate (ALN) 70 mg once weekly (OW) and risedronate (RIS) 5 mg daily between-meal dosing on biochemical markers of bone turnover and bone mineral density (BMD) in postmenopausal women with osteoporosis. Research design and methods: This was a 3-month, randomised, double-blind, placebo-controlled study with a double-blind extension to 12 months. The study enrolled 549 postmenopausal women (ALN 219, RIS 222 and placebo (PBO) 108) who were : 60 years of age at outpatient centres. Main outcome measures: The primary endpoint was reduction in urine N-telopeptides of type 1 collagen (NTx) corrected for creatinine level at 3 months. Secondary parameters included change in BMD at the spine and hip at 6 and 12 months, NTx at 1, 6 and 12 months, and serum bone-specific alkaline phosphatase (BSAP) at 1, 3, 6 and 12 months. Adverse experiences (AEs) were recorded throughout the study for an assessment of treatment safety profiles and tolerability. Results: Over 3 months, ALN produced a significantly greater mean reduction in urine NTx than did RIS (-52% vs -32%, p < 0.001), which was maintained at 12 months. ALN produced a significantly greater mean BMD increase than did RIS at 6 months, and it was maintained at 12 months at the lumbar spine (4.8% vs 2.8%, p < 0.001) and total hip (2.7% vs 0.9%, p < 0.001), as well as at the trochanter and femoral neck. Significant reductions in BSAP with ALN compared to RIS were maintained over the 12 months of treatment. Study size did not allow for meaningful assessment of differences in fracture rates. Tolerability was generally similar between ALN, RIS and PBO, and the incidence of upper GI AEs causing discontinuation and oesophageal AEs was similar in the ALN and RIS groups. Conclusion: In this study, ALN 70 mg OW produced a 50% greater reduction in bone resorption as measured by urine NTx and significantly greater increases in lumbar spine and hip BMD than did RIS 5 mg daily. The treatments had similar safety profiles and were generally well-tolerated. Additional studies are needed comparing OW ALN with OW RIS, which became available after the commencement of the present study. [less ▲]

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See detailIncreased dioxin/PCB body burden in diabetics: findings in a population-based study in Belgium
Fierens, S.; Mairesse, H.; Heilier, H. et al

in Organohalogen Compounds (2003), 60-65

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See detailTous pouvoirs confondus. État, capital et médias à l’ère de la mondialisation
Geuens, Geoffrey ULg

Book published by Éditions EPO (2003)

Le champ médiatique doit être considéré comme un sous-espace constitutif du « champ du pouvoir ». Richement documenté, l’ouvrage décrit très précisément l’intersection des sphères médiatique, économique ... [more ▼]

Le champ médiatique doit être considéré comme un sous-espace constitutif du « champ du pouvoir ». Richement documenté, l’ouvrage décrit très précisément l’intersection des sphères médiatique, économique et politique à l’échelle internationale ; un phénomène qui s’exprime et se consolide notamment à travers la circulation quasi ininterrompue de certains dirigeants de groupes médiatiques (presse écrite et audiovisuelle) entre divers univers sociaux (cabinets ministériels, business clubs, conseils d'administration de multinationales, think tanks, etc.). [less ▲]

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See detailBanana-Mycosphaerella fijiensis interactions.
Lepoivre, Philippe ULg; Busogoro, Jean-Pierre; Etame, Jean-Jacques et al

in Mycosphaerella leaf spot diseases of bananas: presentstatus and outlook. Proceedings of the 2nd International Workshop on Mycosphaerella leaf spot diseases held in San Jose, Costa Rica on20-23 May 2002 (2003)

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See detailApplication of a damage model to an aluminium alloy
Castagne, Sylvie; Habraken, Anne ULg; Cescotto, Serge ULg

in International Journal of Damage Mechanics (2003), 12(1), 5-30

An energy-based isotropic elastoplastic model coupled to damage is implemented in the finite element code LAGAMINE developed for more than fifteen years in the MSM department. In this model, based on the ... [more ▼]

An energy-based isotropic elastoplastic model coupled to damage is implemented in the finite element code LAGAMINE developed for more than fifteen years in the MSM department. In this model, based on the local approach of ductile fracture, effective stresses associated to damage variables are introduced. The damage law allows a continuous description of crack appearance. After a brief description of the model, its identification and its validation for an aluminum alloy are presented. Finally, the research of a global rupture criterion associated to this model is introduced. [less ▲]

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