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See detailThiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals
Makarchikov, Alexander F; Lakaye, Bernard ULg; Gulyai, I. E. et al

in Cellular and Molecular Life Sciences : CMLS (2003), 60(7), 1477-1488

In most organisms, the main form of thiamine is the coenzyme thiamine diphosphate. Thiamine triphosphate (ThTP) is also found in low amounts in most vertebrate tissues and can phosphorylate certain ... [more ▼]

In most organisms, the main form of thiamine is the coenzyme thiamine diphosphate. Thiamine triphosphate (ThTP) is also found in low amounts in most vertebrate tissues and can phosphorylate certain proteins. Here we show that ThTP exists not only in vertebrates but is present in bacteria, fungi, plants and invertebrates. Unexpectedly, we found that in Escherichia coli as well as in Arabidopsis thaliana, ThTP was synthesized only under particular circumstances such as hypoxia (E. coli) or withering (A. thaliana). In mammalian tissues, ThTP concentrations are regulated by a specific thiamine triphosphatase that we have recently characterized. This enzyme was found only in mammals. In other organisms, ThTP can be hydrolyzed by unspecific phosphohydrolases. The occurrence of ThTP from prokaryotes to mammals suggests that it may have a basic role in cell metabolism or cell signaling. A decreased content may contribute to the symptoms observed during thiamine deficiency. [less ▲]

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See detailClinching joining system: validation of numerical models
Pietrapertosa, C.; Zhang, Lihong ULg; Habraken, Anne ULg et al

in Brucato, V. (Ed.) Proceedings of the 6th International ESAFORM Conference on Material Forming (2003)

The clinching process, also known as “press joining”, is a mechanical joining technique for sheet metal. Its basic principle is to clamp together several metal sheets by an impact extrusion between a ... [more ▼]

The clinching process, also known as “press joining”, is a mechanical joining technique for sheet metal. Its basic principle is to clamp together several metal sheets by an impact extrusion between a punch and a die. The joint is formed by a localized cold plastic deformation. Forming is used as a joining method. Within the context of this research, University of Liège is developing numerical models, with the FEM code LAGAMINE, that simulate the clinching process. On the other hand, shear tests on simple joints with one or two clinches were realized and their behaviour is reproduced numerically with LAGAMINE. This work opens the way to the analytical formulation of the behaviour of clinched joints. The article will focus on comparisons between experiments and numerical simulations. First, the identification of model parameters will be explained. Then, the predicted failure modes will be analysed by comparison with the xperiments. [less ▲]

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See detailRelevance of bone mineral density, bone quality and falls in reduction of vertebral and non-vertebral fractures.
Hanssens, L.; Reginster, Jean-Yves ULg

in Journal of musculoskeletal & neuronal interactions (2003), 3(3), 189-93

All epidemiological studies conclude that without prompt, concerted and well-designed prevention programs, the increasing cost related to osteoporotic fractures will become an unbearable burden for the ... [more ▼]

All epidemiological studies conclude that without prompt, concerted and well-designed prevention programs, the increasing cost related to osteoporotic fractures will become an unbearable burden for the community within the next fifteen years. However, the most effective way of setting up such preventive strategies is not yet unequivocally defined. Low bone mass and microarchitectural damage of bone tissue may account for a large part of the epidemiology of vertebral fractures. Extraskeletal determinants, including low muscle strength, poor balance and gait, all resulting in an increased propensity to fall, also play a major role in the occurrence of hip fracture. Depending on the localization of the fractures, the relative importance of skeletal and extraskeletal risk factors can significantly differ. For prevention of vertebral fractures, drugs affecting bone mass and skeletal architecture may provide a substantial benefit while hip fracture prevention will be more successfully targeted by multi-faceted strategies concentrating not only on the skeletal dimension of the fracture but also aiming, either pharmacologically or through multi-intervention programs, at a reduction in the incidence and in the consequences of falls in the elderly. [less ▲]

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See detailInorganic and organic carbon biogeochemistry in the Gautami Godavari estuary (Andhra Pradesh, India) during pre-monsoon : the local impact of extensive mangrove forests
Bouillon, Steven; Frankignoulle, Michel; Dehairs, Frank et al

in Global Biogeochemical Cycles (2003), 17(4),

[1] The distribution and sources of organic and inorganic carbon were studied in the Gautami Godavari estuary (Andhra Pradesh, India) and in a mangrove ecosystem in its delta during pre-monsoon. In the ... [more ▼]

[1] The distribution and sources of organic and inorganic carbon were studied in the Gautami Godavari estuary (Andhra Pradesh, India) and in a mangrove ecosystem in its delta during pre-monsoon. In the oligohaline and mesohaline section (salinity 0–15) of the estuary, internal production of total alkalinity (TAlk) and dissolved inorganic carbon (DIC) was recorded, and the d13CDIC profile suggests that carbonate dissolution may be an important process determining the DIC dynamics in this section of the Godavari. The partial pressure of CO2 (pCO2) was fairly low along the entire salinity gradient, (293–500 ppm), but much higher and more variable (1375–6437 ppm) in the network of tidal mangrove creeks in the delta. Here, variations in the concentration and d13C of the DIC pool were shown to result largely from the mineralization of organic matter. The present study clearly identifies the mangrove creeks as an active site of mineralization and CO2 efflux to the atmosphere, but shows that these changes in the aquatic biogeochemistry are a localized feature, rapidly fading in the adjacent Kakinada Bay. Our data indicate that mineralization of dissolved organic carbon (DOC) of mangrove origin, and its subsequent efflux as CO2 to the atmosphere may represent an important fate for mangrove carbon. Although further quantification of this process in a variety of systems is required, we suggest that some of the current ideas on the role of mangroves in the carbon budget of the coastal zone may need to be reconsidered. [less ▲]

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See detailA conceptual framework to design and support self-directed learning in a blended learning program. A case-stydy: the DES-TEF
Denis, Brigitte ULg

in Journal of Educational Media (2003), 28(2-3), 115-127

This paper relates different strategies developed in order to support the learning process in a blended learning programme involving adults from different backgrounds who are interested in the use of ... [more ▼]

This paper relates different strategies developed in order to support the learning process in a blended learning programme involving adults from different backgrounds who are interested in the use of Information and Communication Technologies for Education (ICTE). Referring to Carré & Pearn’s model of the seven pillars of self-learning, the author describes some principles, tools and resources that have been developed within the framework of a postgraduate diploma and that could be extended to similar adult training programmes. [less ▲]

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See detailDe Cheddar- en Creswell-spitsen van Zeijen (Dr.): ‘projectielen’ of ‘messen’?
Rots, Veerle ULg; Stapert, Dick; Johanssen, Lykke

in Paleo-Aktueel (2003), 13

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See detailVers une politique de qualité, à quel prix ?
Claustriaux, Jean-Jacques ULg; Cordier, L.; Duquesne, Brigitte ULg et al

Scientific conference (2003)

Description de l'utilisation d'une base de données relative aux achats de produits alimentaires effectués par des ménages.

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See detailClonal chromosome aberrations in Philadelphia-negative cells from chronic myelocytic leukemia patients treated with imatinib mesylate: report of two cases.
Herens, Christian ULg; Baron, Frédéric ULg; Croisiau, Christiane et al

in Cancer Genetics & Cytogenetics (2003), 147(1), 78-80

Imatinib mesylate (tested as STI571), an abl kinase inhibitor, induces sustained, complete hematologic and cytogenetic responses in chronic myelocytic leukemia (CML) patients; however, emergence of clonal ... [more ▼]

Imatinib mesylate (tested as STI571), an abl kinase inhibitor, induces sustained, complete hematologic and cytogenetic responses in chronic myelocytic leukemia (CML) patients; however, emergence of clonal chromosomal aberrations in Philadelphia-negative (Ph-) cells during treatment has been reported. We describe two CML patients in chronic phase who presented with complete cytogenetic responses during imatinib mesylate therapy but developed new clonal chromosomal rearrangements in Ph- cells. The first patient presented with a duplication of chromosome 1, dup(1)(q21q42), and the second showed two new clonal aberrations consisting of inv(1)(q12q32) and del(7)(q22) in the same clone. [less ▲]

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See detailStudy of the crp-like gene of Streptomyces coelicolor
Derouaux, Adeline ULg; Titgemeyer, Fritz; Dusart, Jean et al

Poster (2003)

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See detailMeasure Noun constructions : an instance of semantically-driven grammaticalization
Brems, Lieselotte ULg

in International Journal of Corpus Linguistics (2003), 8(2), 283-312

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See detailEvaluation de la Convention Premier Emploi - Analyse économique
Bay, Christelle; Fonder, Muriel; Lejeune, Bernard ULg et al

Report (2003)

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See detailProcessing GPS measurements during periods of high ionospheric activity
Warnant, René ULg; Grevesse, Jonathan; Pottiaux, Eric

in Proceedings of EUREF 2002 Symposium (2003)

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See detailDetails on DARWIN and the Search for Extrasolar Planets
Kaltenegger, L.; Fridlund, M.; Absil, Olivier ULg

in Deming, Drake; Seager, Sara (Eds.) Scientific Frontiers in Research on Extrasolar Planets (2003)

The direct detection of an earth-like planet close to its parent star is challenging because the signal detected from the parent star is between 10[SUB]9[/SUB] and 10[SUB]6[/SUB] times brighter than the ... [more ▼]

The direct detection of an earth-like planet close to its parent star is challenging because the signal detected from the parent star is between 10[SUB]9[/SUB] and 10[SUB]6[/SUB] times brighter than the signal of a planet in the visual and infrared (IR), respectively. Future space based missions like DARWIN and TPF concentrate on the region between 6 and 18 microns, a region that contains the carbon dioxide, water, and ozone spectral features of the atmosphere. Using several small collecting telescopes and a beam combiner allows us to build an instrument with an angular resolution normally associated with monolithic telescopes of much larger diameters. The relative positions of the telescopes, forming the interferometer, are selected such that when the optical signals, collected by the individual telescopes, are coherently combined, the small angular distance between the planet and the star can be resolved. Different configurations of the free flying interferometer array influence the performance of the nulling array. The concepts for space nulling interferometers and the influence of different schemes of beam combination on the detected signal are investigated. The contribution of background noise to the detected signal is examined. [less ▲]

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See detailThe NDWI as a drought index applied to Belgium and Heilongjiang
Tychon, Bernard ULg; Pêcheur, Céline; Ozer, Pierre ULg

in Tychon, Bernard (Ed.) Belgian and Chinese Crop Growth Monitoring Systems: comparison, adaptation and improvement (2003)

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See detailSimenon, le roman et l'Histoire
Denis, Benoît ULg

in Dumortier, Jean-Louis (Ed.) Le Roman de Simenon. Pedigree : entre réalité et fiction (2003)

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