References of "2003"
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See detailRivers, chemical weathering and Earth's climate
Dupre, B.; Dessert, C.; Oliva, P. et al

in Comptes Rendus Geoscience (2003), 335(16), 1141-1160

We detail the results of recent studies describing and quantifying the large-scale chemical weathering of the main types of continental silicate rocks: granites and basalts. These studies aim at ... [more ▼]

We detail the results of recent studies describing and quantifying the large-scale chemical weathering of the main types of continental silicate rocks: granites and basalts. These studies aim at establishing chemical weathering laws for these two lithologies, describing the dependence of chemical weathering on environmental parameters, such as climate and mechanical erosion. As shown within this contribution, such mathematical laws are of primary importance for numerical models calculating the evolution of the partial pressure of atmospheric CO2 and the Earth climate at geological timescales. The major results can be summarized as follow: (1) weathering of continental basaltic lithologies accounts for about 30% of the total consumption of atmospheric CO2 through weathering of continental silicate rocks. This is related to their high weatherability (about eight times greater than the granite weatherability); (2) a simple weathering law has been established for basaltic lithologies, giving the consumption of atmospheric CO2 as a function of regional continental runoff, and mean annual regional temperature; (3) no such simple weathering law can be proposed for granitic lithologies, since the effect of temperature can only be identified for regions displaying high continental runoff; (4) a general law relating mechanical erosion and chemical weathering has been validated on small and large catchments. The consequences of these major advances on the climatic evolution of the Earth are discussed. Particularly, the impacts of the onset of the Deccan trapps and the Himalayan orogeny on the global carbon cycle are reinvestigated. (C) 2003 Academie des sciences. Published by Elsevier SAS. All rights reserved. [less ▲]

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See detailMalignant melanoma
Paquet, Philippe ULg; Hustinx, Roland ULg; Rigo, Pierre ULg et al

in Oehr, Peter; Biersack, Hans_jürgen; Coleman, Edward R (Eds.) PET and PET-CT in Oncology (2003)

PET and PET-CT in Oncology describes the principles of positron emission tomography and is a useful resource for incorporating the technique in clinical practice. In a clear and straightforward fashion ... [more ▼]

PET and PET-CT in Oncology describes the principles of positron emission tomography and is a useful resource for incorporating the technique in clinical practice. In a clear and straightforward fashion, this heavily-illustrated text offers instructive information and overviews of the basic principles of PET and PET-CT as well as the routine clinical PET scanning procedures for all important oncological indications. It is designed to serve as a reference work for specialists in nuclear medicine and radiology (including therapy planning) and for oncologists. It also provides student and physicians in other medical specialities with a general introduction to the effective integration of this modern technique into routine clinical diagnostics. Above all, this volume illustrates the importance of PET and PET-CT in comparison with other imaging techniques. [less ▲]

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See detailQualité du froment d'hiver en Région Wallonne.
Oger, R.; Sinnaeve, G.; Anceau, Christine ULg et al

Book published by REQUASUD (2003)

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See detailIlmenite deposits and their geological environment (with special reference to the Rogaland Anorthosite province, including a geological map at scale 1:75,000)
Duchesne, Jean-Clair ULg; Korneliussen, Are

Book published by NGU (2003)

The Rogaland Anorthosite Province comprises three major massif-type anorthosites, two smaller-sized anorthositic-leuconoritic bodies, as well as a large layered, dominantly noritic intrusion. A mangero ... [more ▼]

The Rogaland Anorthosite Province comprises three major massif-type anorthosites, two smaller-sized anorthositic-leuconoritic bodies, as well as a large layered, dominantly noritic intrusion. A mangero-noritic intrusion is found in the northeastern part of the province and major acidic intrusions are located to the far southeast. The Rogaland Anorthosite Province was emplaced into the Sveconorwegian orogenic belt of southwest Scandinavia at 931±3 Ma. Emplacement took place at around 5.5 kbar producing a thermal aureole with osumilite and pigeonite isograds and evidence for dehydration melting. The early history of the hosting terrane most likely dates back to Gothian or late Pre-Gothian times and contain evidence for numerous episodes of folding and deformation. Contact metamorphism was superimposed on a crustal volume, which had been exposed to Sveconorwegian granulite facies metamorphism between 1024 and 970 Ma. Deformation patterns, mineral compositional considerations and geothermobarometry imply that the Rogaland anorthosites crystallized along a P-T trajectory starting at 10-13 kbar, and were emplaced in a mushy state. The possibility that primitive jotunites may be parental to the andesine anorthosites have recently been substantiated, and experimental data show that these jotunites most likely formed by melting of gabbronoritic sources in the lower crust. The 230 km2 Bjerkreim-Sokndal Layered Intrusion also derive from jotunitic parents, and jotunites form a continuous liquid line of descent filling the gap between basic and acidic rocks in Rogaland. This intrusion contains a >7000 m thick layered cumulate sequence, consisting of virtually all the rock types belonging to the anorthosite kindred. The intrusion morphology, layering and compositional variation result from a variety of magma chamber processes, which are discussed in detail. The Rogaland Anorthosite Province also hosts numerous Fe-Ti oxide deposits of variable size, grade and composition. The oxide deposits have been divided into three basic types based on their oxide-phosphate association; type 1: ilmenite-only, type 2: ilmenite + magnetite and type 3: ilmenite + magnetite + apatite. This excursion guide provides detailed itineraries to most parts of the Rogaland Anorthosite Province, with in-depth descriptions of more than 40 key localities, The itineraries cover the various anorthosites, the Bjerkreim-Sokndal Layered Intrusion, jotunitic and acidic intrusions, the hosting metamorphic complex, as well as Fe-Ti oxide and sulfide deposits. [less ▲]

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See detailRole of Cys221 and Asn116 in the zinc-binding sites of the Aeromonas hydrophila metallo-beta-lactamase.
Vanhove, Marc; Zakhem, M.; Devreese, B. et al

in Cellular and molecular life sciences : CMLS (2003), 60(11), 2501-9

The CphA metallo-beta-lactamase produced by Aeromonas hydrophila exhibits two zinc-binding sites. Maximum activity is obtained upon binding of one zinc ion, whereas binding of the second zinc ion results ... [more ▼]

The CphA metallo-beta-lactamase produced by Aeromonas hydrophila exhibits two zinc-binding sites. Maximum activity is obtained upon binding of one zinc ion, whereas binding of the second zinc ion results in a drastic decrease in the hydrolytic activity. In this study, we analyzed the role of Asn116 and Cys221, two residues of the active site. These residues were replaced by site-directed mutagenesis and the different mutants were characterized. The C221S and C221A mutants were seriously impaired in their ability to bind the first, catalytic zinc ion and were nearly completely inactive, indicating a major role for Cys221 in the binding of the catalytic metal ion. By contrast, the binding of the second zinc ion was only slightly affected, at least for the C221S mutant. Mutation of Asn116 did not lead to a drastic decrease in the hydrolytic activity, indicating that this residue does not play a key role in the catalytic mechanism. However, the substitution of Asn116 by a Cys or His residue resulted in an approximately fivefold increase in the affinity for the second, inhibitory zinc ion. Together, these data suggested that the first zinc ion is located in the binding site involving the Cys221 and that the second zinc ion binds in the binding site involving Asn116 and, presumably, His118 and His196. [less ▲]

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See detailConsidérations sur la rémunération en tant qu'objet de recouvrement
Georges, Frédéric ULg

in Espace judiciaire et social européen (2003)

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See detailL'image du mois. Sous le pont myocardique coule la coronaire.
ROUSSEAU, Anne-Françoise ULg; MIEVIS, Eric

in Revue Médicale de Liège (2003), 58(10), 601-604

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See detailA retrospective study of non-specific rhinitis in 22 cats and the value of nasal cytology and histopathology
Michiels, L.; Day, M. J.; Snaps, Frédéric ULg et al

in Journal of Feline Medicine and Surgery (2003), 5(5), 279-285

Case records from 40 cats subjected to rhinoscopic examination for investigation of chronic nasal disease were reviewed. Cases in which no specific underlying cause (eg neoplasia) was detected were ... [more ▼]

Case records from 40 cats subjected to rhinoscopic examination for investigation of chronic nasal disease were reviewed. Cases in which no specific underlying cause (eg neoplasia) was detected were further selected for detailed retrospective study. In these 22 cats (55% of the initial population), a final diagnosis of non-specific chronic nasal disease was made. The radiographic, rhinoscopic, cytological and histopathological findings were reviewed. Mucosal biopsy specimens were obtained in 20 cases. Despite clinical signs of more than 4 weeks duration, histopathology indicated acute inflammation in four cases. Two cases had chronic lymphoplasmacytic inflammation and 14 had mixed (lymphoplasmacytic and neutrophilic) inflammation. Specimens for cytology were obtained from 17 cases by brush sampling. Three of these samples were not diagnostic due to the poor quality of the slides; one showed normal cytology. Acute inflammation was diagnosed by cytology (n = 11) more commonly than chronic (n = 1) or mixed inflammation (n = 1). Concurrent samples, of quality suitable for both histopathological and cytological interpretation, were collected from 12 cases only. Cytological results were in agreement with the histological results in 25%, of these cases, the main discrepancy being the nature of the dominant inflammatory cell type. Therefore cytology does not appear to be a reliable means for detection of chronic inflammation. Further studies are needed in order to investigate the correlation between the nature of mucosal inflammation as defined by both histological and cytological evaluation, and the relationship of these test results to prognosis and therapy. (C) 2003 Published by Elsevier Ltd on behalf of ESFM and AAFP. [less ▲]

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See detailBiomarqueurs de toxicité et anomalies métaboliques dans les principales intoxications graves. Symptomatologie clinique et toxique. Le prélèvement conservatoire.
Goullé, Jean-Pierre; Lhermitte, Michel; Bartholi, M. et al

in Annales de Biologie Clinique (2003), 61

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See detailEnquête sur les "contes" de Voltaire (II)
Tilkin, Françoise ULg

in Cahiers Voltaire : Revue Annuelle de la Société Voltaire (2003), 2

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See detailConsequences of imperfect insulation - Numerical Modelling
Franssen, Jean-Marc ULg

in Journal of Fire Protection Engineering (2003), 18

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See detailMinitransplants: allogeneic stem cell transplantation with reduced toxicity.
Beguin, Yves ULg; Baron, Frédéric ULg

in Acta Clinica Belgica (2003), 58(1), 37-45

Allogeneic hematopoietic stem cell transplantation (HSCT) is used for the treatment of selected hematological malignancies. Its curative potential is based on two very different mechanisms, involving the ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (HSCT) is used for the treatment of selected hematological malignancies. Its curative potential is based on two very different mechanisms, involving the conditioning regimen and the graft-versus-host reactions, respectively. The high-dose chemo-radiotherapy conditioning regimen is aimed at destroying tumor cells, ablating the host immune system (to prevent rejection) and eliminating the host bone marrow (to "make space" for donor stem cells). However, the definitive eradication of tumor cells is also largely mediated by an immune-mediated destruction of malignant cells by donor lymphocytes termed graft-versus-leukemia (GVL) or graft-versus-tumor (GVT) effect. However, because of its toxicity, conventional allogeneic HSCT is restricted to younger (< 55 years) and fitter patients. These observations led several groups to set up new (less toxic) transplant protocols based on a two step approach: first the use of immunosuppressive (but nonmyeloablative) conditioning regimens providing sufficient immunosuppression to achieve engraftment of allogeneic hematopoietic stem cells and, in a second step, destruction of malignant cells by the GVL effect. These transplants are called nonmyeloablative HSCT or reduced-conditioning HSCT or minitransplants. Preliminary results show that minitransplants are feasible with a relatively low transplant-related mortality (TRM) even in patients up to 70 years. In addition, strong anti-tumor responses are observed in several hematological malignancies as well as in some patients with renal cell carcinoma. As the benefits of minitransplants over alternative forms of treatment remain to be demonstrated, this strategy should be restricted to patients included in clinical trials. [less ▲]

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See detailSagriwatel : une vue d'ensemble sur les parcelles.
Tychon, Bernard ULg; Istasse, Alain

Article for general public (2003)

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See detailMechanical behaviour of chalk reservoir: Numerical modelling of water sensitivity and time dependence effects
Collin, Frédéric ULg; Cui, Yu Jun; Schroeder, Christian ULg et al

Conference (2003)

The paper proposes two numerical models ot the mechanical behaviour of chalk. First, an elasto-plastic constitutive law reproduces the different plastic mechanisms of the chalk and the influence of pore ... [more ▼]

The paper proposes two numerical models ot the mechanical behaviour of chalk. First, an elasto-plastic constitutive law reproduces the different plastic mechanisms of the chalk and the influence of pore fluids by introducing the concept of suction. Secondly, a model able to reproduce time dependence behaviour. Eventually, the paper gives a simulation of an academic reservoir during depletion and waterflooding phase. [less ▲]

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See detailThe monitoring of the ionospheric activity using GPS measurements
Warnant, René ULg; Stankov, Stanimir; Jodogne, Jean-Claude et al

in Proceedings of the COST271 2002 workshop (2003)

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See detailThe NDWI as a drought index applied to Belgium and Heilongjiang
Tychon, Bernard ULg; Pêcheur, Céline; Ozer, Pierre ULg

in Tychon, Bernard (Ed.) Belgian and Chinese Crop Growth Monitoring Systems: comparison, adaptation and improvement (2003)

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See detailLichenometric application to recent dynamics and sediment transport of a Corsican stream (Figarella River– France).
Gob, Frédéric ULg; Petit, François ULg; Bravard, J. P. et al

in Quaternary Science Reviews (2003)

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See detailEstrogens reduce the expression of YKL-40 in the retina: Implications for eye and joint diseases
Rakic, Jean-Marie ULg; Lambert, Vincent ULg; Deprez, Manuel ULg et al

in Investigative Ophthalmology & Visual Science (2003), 44(4), 1740-1746

PURPOSE. To identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy and to select differentially ... [more ▼]

PURPOSE. To identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy and to select differentially expressed genes that could be relevant to the natural history of human age-related macular degeneration (AMD). METHODS. Chorioretinal tissues from two groups of 25 treated and untreated OVX mice were analyzed by using cDNA array technology. The expression level of selected genes was confirmed in triplicate by RT-PCR and related to the estrogenic status of the animals. Expression of the YKL-40 gene was further investigated in intact or diseased human retinas and in a murine model of experimental choroidal neovascularization (CNV), using laser pressure catapulting. RESULTS. Of the approximately, 10,000 genes screened, only YKL-40 expression was significantly downregulated by 17-beta-estradiol. YKL-40 was expressed in intact human neural retina and in the RPE. The expression of YKL-40 was upregulated in experimental CNV and in neovascular membranes extracted from patients affected by the exudative form of AMD. CONCLUSIONS. These observations indicate that YKL-40 expression in the retina is modulated by serum levels of estradiol. This protein could be relevant to the development of AMD and is also a new mediator to take into account when evaluating the broad consequences of hormonal replacement therapy. [less ▲]

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