References of "2003"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailPrevention de la nephropathie diabetique: de la microalbuminurie a l'insuffisance renale terminale.
Weekers, Laurent ULg; Scheen, André ULg; Rorive, Georges ULg

in Revue Médicale de Liège (2003), 58(5), 297-306

Diabetic nephropathy is one of the leading causes of end-stage renal failure in western countries. This disease develops over several years. Early stages, if they are detected in time, can lead to ... [more ▼]

Diabetic nephropathy is one of the leading causes of end-stage renal failure in western countries. This disease develops over several years. Early stages, if they are detected in time, can lead to preventive treatment at a moment when the disease is still reversible. This paper reviews the main primary and secondary preventive measures that have been proven efficacious. Those are essentially the optimal treatment of hyperglycaemia and hypertension, and probably the use of agents that specifically block the renin-angiotensin axis. We briefly discuss the results of the main studies that have led to those conclusions. [less ▲]

Detailed reference viewed: 321 (4 ULg)
Full Text
Peer Reviewed
See detailLa sentence arbitrale
Caprasse, Olivier ULg

in Actualités du Droit (2003), 3

Detailed reference viewed: 11 (0 ULg)
See detailMerleau-Ponty : philosophie et peinture (perception et expression)
Steinmetz, Rudy ULg

Conference given outside the academic context (2003)

Detailed reference viewed: 26 (2 ULg)
Full Text
Peer Reviewed
See detailUtilisation des scories métallurgiques en dynamique fluviale : détermination de la compétence effective des rivières et estimation des vitesses de progression de la charge de fond.
Houbrechts, Geoffrey ULg; Petit, François ULg

in Géomorphologie : Relief, Processus, Environnement (2003), (1), 3-12

Les compétences effectives de trois rivières du nord de l’Ardenne (Belgique) ont pu être estimées grâce à la présence de nombreuses macroscories dans leur charge de fond. En effet, ces scories, rejetées ... [more ▼]

Les compétences effectives de trois rivières du nord de l’Ardenne (Belgique) ont pu être estimées grâce à la présence de nombreuses macroscories dans leur charge de fond. En effet, ces scories, rejetées par les anciens fondeurs dans les rivières, ont été soumises, pendant plusieurs siècles, à de nombreuses crues mobilisatrices. Par conséquent, elles peuvent être considérées comme un marqueur représentatif de la compétence effective des rivières sur une très longue période et sur une grande distance. Ainsi, en comparant la taille des scories en amont et en aval d’un secteur de pertes karstiques (plusieurs kilomètres), nous avons montré que ces pertes n’entraînent pas de baisse sensible de la compétence de la rivière. Une relation entre la taille des scories prélevées et les puissances spécifiques développées dans les secteurs de prélèvement a également été établie. Cette relation montre que le maximum de puissance spécifique des rivières ardennaises se produit dans les rivières dont le bassin versant est voisin de 150 km². Finalement, des scories retrouvées dans l’Ourthe, environ 10 km en aval du site de production le plus proche, ont été utilisées pour évaluer la vitesse de progression de la « vague sédimentaire ». En effet, ces scories sont soumises aux mêmes conditions hydrologiques et de piégeage que les éléments naturels de la charge de fond. Après avoir daté le début du fonctionnement du site de production le plus proche (1450), nous avons calculé la vitesse de progression des scories qui est comprise entre 1,8 et 2,3 km/siècle. [less ▲]

Detailed reference viewed: 59 (22 ULg)
Full Text
Peer Reviewed
See detailMinitransplants: allogeneic stem cell transplantation with reduced toxicity.
Beguin, Yves ULg; Baron, Frédéric ULg

in Acta Clinica Belgica (2003), 58(1), 37-45

Allogeneic hematopoietic stem cell transplantation (HSCT) is used for the treatment of selected hematological malignancies. Its curative potential is based on two very different mechanisms, involving the ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (HSCT) is used for the treatment of selected hematological malignancies. Its curative potential is based on two very different mechanisms, involving the conditioning regimen and the graft-versus-host reactions, respectively. The high-dose chemo-radiotherapy conditioning regimen is aimed at destroying tumor cells, ablating the host immune system (to prevent rejection) and eliminating the host bone marrow (to "make space" for donor stem cells). However, the definitive eradication of tumor cells is also largely mediated by an immune-mediated destruction of malignant cells by donor lymphocytes termed graft-versus-leukemia (GVL) or graft-versus-tumor (GVT) effect. However, because of its toxicity, conventional allogeneic HSCT is restricted to younger (< 55 years) and fitter patients. These observations led several groups to set up new (less toxic) transplant protocols based on a two step approach: first the use of immunosuppressive (but nonmyeloablative) conditioning regimens providing sufficient immunosuppression to achieve engraftment of allogeneic hematopoietic stem cells and, in a second step, destruction of malignant cells by the GVL effect. These transplants are called nonmyeloablative HSCT or reduced-conditioning HSCT or minitransplants. Preliminary results show that minitransplants are feasible with a relatively low transplant-related mortality (TRM) even in patients up to 70 years. In addition, strong anti-tumor responses are observed in several hematological malignancies as well as in some patients with renal cell carcinoma. As the benefits of minitransplants over alternative forms of treatment remain to be demonstrated, this strategy should be restricted to patients included in clinical trials. [less ▲]

Detailed reference viewed: 22 (3 ULg)
Full Text
See detailPion Structure Function and violation of the Momentum Sum Rule
Lansberg, Jean-Philippe ULg; Bissey, F.; Cudell, Jean-René ULg et al

in Blin, A. H.; Hiller, B.; Ruivo, M. C. (Eds.) et al Hadron Physics: Effective Theories of Low Energy QCD N°2 (2003)

We present a method to evaluate the pion structure functions from a box diagram calculation. Pion and constituent quark fields are coupled through the simplest pseudoscalar coupling. The gamma^* pi -> q ... [more ▼]

We present a method to evaluate the pion structure functions from a box diagram calculation. Pion and constituent quark fields are coupled through the simplest pseudoscalar coupling. The gamma^* pi -> q \bar q cross-section is evaluated and related to the structure functions. We then show that the introduction of non-perturbative effects, related to the pion size and preserving gauge invariance, provides us with a straighforward relation with the quark distribution. It is predicted that higher-twist terms become negligible for Q^2 larger than about 2 GeV^2 and that quarks in the pion have a momentum fraction smaller than in the proton. We enlarge the discussion concerning this violation of the momentum sum rule, emphasizing that the sum rule is recovered in the chiral limit and also when the finite size condition is not imposed. [less ▲]

Detailed reference viewed: 55 (3 ULg)
Full Text
Peer Reviewed
See detailTrophic habits and aquatic microhabitat use in gilled immature, paedomorphic and metamorphic Alpine newts (Triturus alpestris apuanus) in a pond in central Italy
Denoël, Mathieu ULg; Andreone, F.

in Belgian Journal of Zoology (2003), 133(2), 95-102

Current evolutionary models suggest that the presence of heterogeneous habitats favours the evolution of polymorphisms. In such cases, alternative phenotypes can coexist because they use different ... [more ▼]

Current evolutionary models suggest that the presence of heterogeneous habitats favours the evolution of polymorphisms. In such cases, alternative phenotypes can coexist because they use different resources. Facultative paedomorphosis is a heterochronic polymorphism in which a morph - the paedomorph - retains larval traits during the adult stage while the other morph - the metamorph - is fully metamorphosed. The aim of this study was to determine the microhabitat use and the diet of Alpine newt paedomorphs, metamorphs and immatures (Triturus alpestris apuanus) coexisting in a small pond in Tuscany, central Italy, i.e. in a habitat where dimorphism is not expected. Although the two adult morphs do not use exactly the same resources, resource partitioning was weaker than in deep Alpine lakes. Nevertheless, the diet of immature gilled newts (larvae) differed from that of adults (metamorphs and paedomorphs). While the larvae eat a large number of planktonic organisms, the adults focus on insect larvae and newt eggs. The differences in resource use favour the coexistence of aquatic juveniles and adults. In the studied pond, facultative paedomorphosis was previously shown to be favoured by a precocious maturity of the paedomorphs. This study shows that the coexistence of paedomorphs and metamorphs may also be supported by some dietary and spatial segregation, although any advantages gained by this pattern are rather limited in the adult stage. [less ▲]

Detailed reference viewed: 252 (17 ULg)
See detailMinorité prolongée, interdiction et conseil judiciaire: les dernières années
Leleu, Yves-Henri ULg

in Leleu, Yves-Henri (Ed.) Les incapacités (2003)

Detailed reference viewed: 101 (8 ULg)
Full Text
See detailConclusions. Structures macro et micro politiques en conflits: l'exemple des albanophones en occident post-industriel.
Verjans, Pierre ULg

in Vatz-Laaroussi, Michèle; Manço, Altay (Eds.) Jeunesses, citoyennetés, violences : Réfugiés albanais en Belgique et au Québec (2003)

La confrontation de la structuration de base du système politique européen au vécu des jeunes réfugiés albanophones et aux discours qu'ils produisent amène à poser la question de leur double affiliation d ... [more ▼]

La confrontation de la structuration de base du système politique européen au vécu des jeunes réfugiés albanophones et aux discours qu'ils produisent amène à poser la question de leur double affiliation d'origine et d'arrivée en cherchant une solution dans une dynamique de transfert mimétique du groupe de référence au groupe d'apartenance. Deux modèles se dégagent de cette confrontation, l'un "Léonardo di Caprio" composé d'un hybride incarnant les migrations et le rêve américano-européen de l'acquisition d'une force de travail échangeable sur le marché du travail mondial et l'autre "Mohammed Atta", hétéroéférentiel cherchant à passer inaperçu dans les mailles du contrôle de la richesse, jouant la banalité pour poser un acte de révolte. [less ▲]

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailQuantification of angiogenesis on the rat aortic ring assay.
Blacher, Silvia ULg; Devy, L.; Noël, Agnès ULg et al

in Image Analysis and Stereology (2003), 22

Image analysis is used to quantify angiogenesis on the rat aortic ring model. This technique allows to determine: (1) the aortic ring area and factor shape; (2) the number of microvessels, the total ... [more ▼]

Image analysis is used to quantify angiogenesis on the rat aortic ring model. This technique allows to determine: (1) the aortic ring area and factor shape; (2) the number of microvessels, the total number of branching, the maximal microvessel length and the number of microvessels in function of the distance to the aortic ring; (3) the total number of isolated fibroblast-like cells and the number of fibroblast-like cells in function of the distance to the aortic ring. We show that this method is suitable to quantify spontaneous angiogenesis as well as to analyse a complex microvascular network induced by vascular endothelial growth factor (VEGF). [less ▲]

Detailed reference viewed: 60 (3 ULg)
Full Text
See detailNumerical mdeling of hydro-mechanical fracture behaviour
Guiducci, Chiara; Collin, Frédéric ULg; Radu, Jean-Pol ULg et al

Conference (2003)

A numerical approach for modeling coupled Hydro-Mechanical fracture behavior in 2D is presented in this paper. This approach accounts for the strong dependence of the flow characteristics on fracture ... [more ▼]

A numerical approach for modeling coupled Hydro-Mechanical fracture behavior in 2D is presented in this paper. This approach accounts for the strong dependence of the flow characteristics on fracture apertures and offers an anisotropic description of the flow propagation in the fracture. An interface finite element and a constitutive model are developed . In order to validate the applicability of the model to general geomechanic problems, 2D simulations were performed. Results show the good application of the mathematical model and the fundamental hydraulic role played by the fractures. [less ▲]

Detailed reference viewed: 34 (3 ULg)
See detailFengycin penetration into a DPPC monlayer: a study using the Langmuir trough technique with the Brewster angle microscopy
Deleu, Magali ULg

in International symposium on surface and colloid chemistry for the life sciences (2003)

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailEstrogens reduce the expression of YKL-40 in the retina: Implications for eye and joint diseases
Rakic, Jean-Marie ULg; Lambert, Vincent ULg; Deprez, Manuel ULg et al

in Investigative Ophthalmology & Visual Science (2003), 44(4), 1740-1746

PURPOSE. To identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy and to select differentially ... [more ▼]

PURPOSE. To identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy and to select differentially expressed genes that could be relevant to the natural history of human age-related macular degeneration (AMD). METHODS. Chorioretinal tissues from two groups of 25 treated and untreated OVX mice were analyzed by using cDNA array technology. The expression level of selected genes was confirmed in triplicate by RT-PCR and related to the estrogenic status of the animals. Expression of the YKL-40 gene was further investigated in intact or diseased human retinas and in a murine model of experimental choroidal neovascularization (CNV), using laser pressure catapulting. RESULTS. Of the approximately, 10,000 genes screened, only YKL-40 expression was significantly downregulated by 17-beta-estradiol. YKL-40 was expressed in intact human neural retina and in the RPE. The expression of YKL-40 was upregulated in experimental CNV and in neovascular membranes extracted from patients affected by the exudative form of AMD. CONCLUSIONS. These observations indicate that YKL-40 expression in the retina is modulated by serum levels of estradiol. This protein could be relevant to the development of AMD and is also a new mediator to take into account when evaluating the broad consequences of hormonal replacement therapy. [less ▲]

Detailed reference viewed: 69 (21 ULg)
Full Text
Peer Reviewed
See detailPostnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons.
Belachew, Shibeshih ULg; Chittajallu, Ramesh; Aguirre, Adan A. et al

in Journal of Cell Biology (2003), 161(1), 169-86

Neurogenesis is known to persist in the adult mammalian central nervous system (CNS). The identity of the cells that generate new neurons in the postnatal CNS has become a crucial but elusive issue. Using ... [more ▼]

Neurogenesis is known to persist in the adult mammalian central nervous system (CNS). The identity of the cells that generate new neurons in the postnatal CNS has become a crucial but elusive issue. Using a transgenic mouse, we show that NG2 proteoglycan-positive progenitor cells that express the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene display a multipotent phenotype in vitro and generate electrically excitable neurons, as well as astrocytes and oligodendrocytes. The fast kinetics and the high rate of multipotent fate of these NG2+ progenitors in vitro reflect an intrinsic property, rather than reprogramming. We demonstrate in the hippocampus in vivo that a sizeable fraction of postnatal NG2+ progenitor cells are proliferative precursors whose progeny appears to differentiate into GABAergic neurons capable of propagating action potentials and displaying functional synaptic inputs. These data show that at least a subpopulation of postnatal NG2-expressing cells are CNS multipotent precursors that may underlie adult hippocampal neurogenesis. [less ▲]

Detailed reference viewed: 25 (3 ULg)
Full Text
Peer Reviewed
See detailLipides, dépression et suicide
Colin, A.; Reggers, Jean ULg; Castronovo, Vincenzo ULg et al

in Encéphale (L') (2003), 29(1, JAN-FEB), 49-58

Polyunsatured fatty acids are made out of a hydrocarbonated chain of variable length with several double bonds. The position of the first double bond (omega; omega) differentiates polyunsatured omega3 ... [more ▼]

Polyunsatured fatty acids are made out of a hydrocarbonated chain of variable length with several double bonds. The position of the first double bond (omega; omega) differentiates polyunsatured omega3 fatty acids (for example : alpha-linolenic acid or alpha-LNA) and polyunsatured omega6 fatty acids (for example : linoleic acid or LA). These two classes of fatty acids are said to be essential because they cannot be synthetised by the organism and have to be taken from alimentation. The omega3 are present in linseed oil, nuts, soya beans, wheat and cold water fish whereas omega6 are present in maize, sunflower and sesame oil. Fatty acids are part of phospholipids and, consequently, of all biological membranes. The membrane fluidity, of crucial importance for its functionning, depends on its lipidic components. Phospholipids composed of chains of polyunsatured fatty acids increase the membrane fluidity because, by bending some chains, double bonds prevent them from compacting themselves perfectly. Membrane fluidity is also determined by the phospholipids/free cholesterol ratio, as cholesterol increases membrane viscosity. A diet based on a high proportion of essential polyunsatured fatty acids (fluid) would allow a higher incorporation of cholesterol (rigid) in the membranes to balance their fluidity, which would contribute to lower blood cholesterol levels. Brain membranes have a very high content in essential polyunsatured fatty acids for which they depend on alimentation. Any dietary lack of essential polyunsatured fatty acids has consequences on cerebral development, modifying the activity of enzymes of the cerebral membranes and decreasing efficiency in learning tasks. Epidemiological data - The prevalence of depression seems to increase continuously since the beginning of the century. Though different factors most probably contribute to this evolution, it has been suggested that it could be related to an evolution of alimentary patterns in the Western world, in which polyunsatured omega fatty acids contained in fish, game and vegetables have been largely replaced by polyunsatured omega6 fatty acids of cereal oils. Some epidemiological data support the hypothesis of a relation between lower depression and/or suicide rates and a higher consumption of fish. These data do not however prove a relation of causality. Cholesterol and depression - Several cohort studies (on nondepressed subjects) have assessed the relationship between plasma cholesterol and depressive symptoms with contradictory results. Though some results found a significant relationship between a decrease of total cholesterol and high scores of depression, some other did not. Studies among patients suffering from major depression signalled more constantly an association between low cholesterol and major depression. Besides, some trials showed that clinical recovery maybe associated with a significant increase of total cholesterol. Cholesterol and suicidal behaviour - The hypothesis that a low cholesterol level may represent a suicidal risk factor was discovered accidentally following a series of epidemiological studies which revealed an increase of the suicidal risk among subjects with a low cholesterol level. Though some contradictory studies do exist, this relationship has been confirmed by several subsequent cohort studies. These findings have challenged the vast public health programs aimed at promoting the decrease of cholesterol, and even suggested to suspend the administration of lipid lowering drugs. Recent clinical studies on populations treated whith lipid lowering drugs showed nevertheless a lack of significant increase of mortality, either by suicide or accident. In addition, several controlled studies among psychiatric patients revealed a decrease of the concentrations of plasma cholesterol among patients who had attempted suicide in comparison with other patients. Polyunsaturated fatty acids and depression - In major depression, all studies revealed a significant decrease of the polyunsaturated omega3 fatty acids and/or an increase of the omega6/omega3 ratio in plasma and/or in the membranes of the red cells. In addition, two studies found a higher severity of depression when the level of polyunsaturated omega fatty acids or the ratio omega3/omega6 was low. Parallel to these modifications, other biochemical perturbations have been reported in major depression, particularly an activation of the inflammatory response system, resulting in an increase of the pro-inflammatory cytokines (interleukins: IL-1beta, IL-6 and interferon gamma) and eicosanoids (among others, prostaglandin E2) in the blood and the CSF of depressed patients. These substances cause a peroxidation and, consequently a catabolism of membrane phospholipids, among others those containing polyunsaturated fatty acids. The cytokines and eicosanoids derive from polyunsaturated fatty acids and have opposite physiological functions according to their omega or omega6 precursor. Arachidonic acid (omega6) is, among others, precursor of pro-inflammatoty prostaglandin E2 (PGE2), whereas polyunsaturated W fatty acids inhibit the formation of PGE2. It has been shown that a dietary increase of polyunsaturated W fatty acids reduced strongly the production of IL-1beta, IL-2, IL-6 and TNF-alpha (tumor necrosis factor-alpha). In contrast, diets with a higher supply of linoleic acid (omega6) increased significantly the production of pro-inflammatory cytokines, like TNF-alpha. Therefore, polyunsaturated omega3 fatty acids could be associated at different levels in the pathophysiology of major depression, on the one hand through their role in the membrane fluidity which influences diverse steps of neurotransmission and, on the other hand, through their function as precursor of pro-inflammatory cytokines and eicosanoids disturbing neurotransmission. In addition, antidepressants could exhibit an immunoregulating effect by reducing the release of pro-inflammatory cytokines, by increasing the release of endogenous antagonists of pro-inflammatory cytokines like IL-10 and, finally, by acting like inhibitors of cyclo-oxygenase. Therapeutic use of fatty acids - Data available concerning the administration of supplements of DHA (docosahexanoic acid) or other polyunsaturated fatty acids omega3 are limited. In a double blind placebo-controlled study on 30 patients with bipolar disorder, the addition of polyunsaturated omega3 fatty acids was associated with a longer period of remission. Moreover, nearly all the other prognosis measures were better in the omega3 group. Very recently, a controlled trial showed the benefits of adding an omega3 fatty acid, eicosopentanoic acid, among depressed patients. After 4 weeks, six of the 10 patients receiving the fatty acid were considered as responders in comparison with only one of the ten patients receiving placebo. Conclusions Some epidemiological, experimental and clinical data favour the hypothesis that polyunsaturated fatty acids could play a role in the pathogenesis and/or the treatment of depression. More studies however are needed in order to better precise the actual implication of those biochemical factors among the various aspects of depressive illness. [less ▲]

Detailed reference viewed: 86 (10 ULg)