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See detailImproving spatial information extraction for local and regional authorities using Very-High-Resolution data - geometric aspects.
Devriendt, Dennis; Goossens, Rudi; De Wulf, Alain et al

in International Archives of Photogrammetry, Remote Sensing and Spatial Information Sciences (2003), 34(XXX),

The purpose of the presented research project is to investigate how present-day EO-technology can support local and regional decision-making, particularly in Belgium, and to develop prototype versions of ... [more ▼]

The purpose of the presented research project is to investigate how present-day EO-technology can support local and regional decision-making, particularly in Belgium, and to develop prototype versions of value-added products that fulfil some of the actual information needs, as expressed by Belgian authorities at the local and at the regional level. To accomplish this goal the proposal addresses both technical and user-oriented issues, and builds on the experience of five research teams, each with its own background and particular know-how. The most important objectives of the project are: - to define optimal methods for improved spatial information extraction from high- and very-high resolution data, based on innovative processing techniques; - to identify useful EO-applications at the level of local and regional decision making that are made possible by applying the information extraction methods that will be developed; in this case especially 3D information - to define and develop value-added core data products that will support these applications, and that can be consulted with easy-to-use, widely available IT-tools (CD-ROM, Internet, …). One of the technical research modules is focussing on the geometrical aspects of VHR data processing. In terms of spatial resolution, VHR data have the required level of detail to resolve individual objects in the landscape, in a similar way as airborne data. As such, they have the potential of becoming a useful data source for the extraction of detailed, object-related information, and for the production of large-scale cartographic reference data. The geometry of VHR sensor data, however, completely differs from the geometry of aerial photographs (Bethel et al., 2001). Research is going on to evaluate the geometric qualities of present and future VHR standard data products, from the moment they become available, and to examine what level of geometric accuracy is attained with these data, depending on image parameters, processing strategies, and terrain characteristics (Zhou and Li, 2000). The main objectives of the research module on geometric aspects of VHR data processing are: a) to define an optimal procedure for the derivation of envelope DSMs (Digital Surface Models) and ortho-photoplans from VHR data; b) to develop a theoretical model to study the effect of the oblique viewing angle of VHR data on image displacements caused by building height and relief; c) to evaluate the geometric accuracy of satellite-derived envelope DSMs and ortho-corrected image data in comparison with similar products obtained by means of large-scale aerial photography. The module about geometrical aspects is divided into six specific tasks. a) GPS database creation b) Creation of reference envelope DSMs based on aerial photography c) Ortho-rectification of VHR images and aerial photography based on reference DSMs d) Evaluation of the quality of VHR geo-referenced data e) Modelling of displacements caused by terrain morphology and sensor viewing angle f) Development of envelope DEMs from VHR stereoscopic imagery The project is now in the stage where the quality of the georeferenced and orthorectified data is evaluated. [less ▲]

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See detailOrganisme génétiquement modifié
du Jardin, Patrick ULg

in Morère, Jean-Louis; Pujol, Raymond (Eds.) Dictionnaire raisonné de Biologie (2003)

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See detailHistoire de la littérature belge francophone (1830-2000)
Bertrand, Jean-Pierre ULg; Biron, Michel; Denis, Benoît ULg et al

Book published by Fayard (2003)

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See detailSyncope sur passage en tachycardie ventriculaire par accélération d’une fibrillation auriculaire
Guillaume, T.; Melon, Pierre ULg; Bouffioux, Laurent ULg et al

in Revue Médicale de Liège (2003), 58(7-8), 468-471

We report a rare case of rapid atrial fibrillation triggering an episod of ventricular tachycardia. We review the literature and discuss the potential mechanisms of the ventricular arrhythmia.

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See detailLoss of nucleotide regulation of epithelial chloride transport in the jejunum of P2Y4-null mice
Robaye, B.; Ghanem, E.; Wilkin, F. et al

in Molecular Pharmacology (2003), 63(4), 777-783

The P2Y4 receptor is responsive to UTP in human and to ATP and UTP in rodents. With the aim of identifying its pharmacotherapeutic interest, we generated P2Y4-null mice by a classic gene targeting method ... [more ▼]

The P2Y4 receptor is responsive to UTP in human and to ATP and UTP in rodents. With the aim of identifying its pharmacotherapeutic interest, we generated P2Y4-null mice by a classic gene targeting method. The proportion of genotypes was consistent with X-linked Mendelian transmission. Gene inactivation was checked by the complete disappearance of P2Y4 receptor mRNA from liver, stomach, and intestine. The P2Y4-null mice had a grossly normal behavior, growth, and reproduction. Chloride secretion by the jejunal epithelium was assessed in Ussing chambers by the measurement of the short circuit current in the presence of phlorizin. We show here that the UTP- and ATPinduced chloride secretory responses observed in wild-type mice are abolished in P2Y4-null mice. This is the first clearcut demonstration of a biological role of the P2Y4 receptor [less ▲]

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See detailThéorie économique et marchandisation des services non marchands
Mertens de Wilmars, Sybille ULg; Lefebvre, Mathieu ULg

in Non Marchand : Management, Droit et Finance (2003), (11), 11-27

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See detailEvaluation of false transrectal ultrasonographic pregnancy diagnoses in sheep by measuring the plasma level of pregnancy-associated glycoproteins
Karen, A.; Beckers, Jean-François ULg; Sulon, Joseph ULg et al

in Reproduction Nutrition Development (2003), 43(6, NOV-DEC), 577-586

The present study was undertaken to investigate to what extent pregnancy diagnoses made by transrectal ultrasonography could be confirmed by measurements of plasma concentration of ovine pregnancy ... [more ▼]

The present study was undertaken to investigate to what extent pregnancy diagnoses made by transrectal ultrasonography could be confirmed by measurements of plasma concentration of ovine pregnancy-associated glycoproteins (ovPAG). A total of 424 Awassi x Merino ewes were synchronized for estrus and examined by transrectal ultrasonography. In Experiment 1, the ewes (n = 156) were repeatedly scanned in a standing position on d 29, 36 and 50 of gestation. Similarly, the ewes (n = 268) in Experiment 2 were scanned on d 24, 29 and 34 of gestation, but these ewes were fasted for 12 h prior to the examination and the abdominal wall of each animal was lifted up by the hands of the assistant during the scanning. Blood samples were withdrawn after each transrectal ultrasonographic examination in both experiments. Ovine PAG concentrations were measured in plasma by a heterologous radioimmunoassay and the cut-off value for pregnancy was greater than or equal to 1 ng.mL(-1). Based on the lambing performance, in Experiment 1, altogether 47 false negative and 38 false positive diagnoses were made by transrectal ultrasonography in 24 and 33 ewes, respectively between d 29 and 50 of gestation. In Experiment 2, altogether 8 false negative and 13 false positive diagnoses both were made in 7 ewes between d 24 and 34 of gestation. In both experiments, all ewes with false negative diagnoses had ovPAG concentrations higher than the threshold level for pregnancy diagnosis and all ewes with false positive diagnoses had ovPAG concentrations lower than the threshold of pregnancy. Furthermore, by the PAG-RIA test all lambed or aborted ewes (n = 63) were correctly diagnosed as pregnant and with three exceptions, all non-lambed ewes (n = 361) were correctly diagnosed as non-pregnant during the examined periods of both experiments. [less ▲]

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See detailRetreatment of hepatitis C non-responsive to interferon. A placebo controlled randomized trial of ribavirin monotherapy versus combination therapy with Ribavirin and Interferon in 121 patients in the Benelux [ISRCTN53821378]
Veldt, Bart J; Brouwer, Johannes T; Adler, Michael et al

in BMC Gastroenterology (2003), 3(1), 24

BACKGROUND: Evidence based medicine depends on unbiased selection of completed randomized controlled trials. For completeness it is important to publish all trials. This report describes the first large ... [more ▼]

BACKGROUND: Evidence based medicine depends on unbiased selection of completed randomized controlled trials. For completeness it is important to publish all trials. This report describes the first large randomised controlled trial where combination therapy was compared to placebo therapy and to ribavirin monotherapy, which has not been published until now. METHODS: One hundred and twenty one patients with chronic hepatitis C and elevated transaminases who did not respond to previous treatment with standard interferon monotherapy, were included from 16 centers in Belgium, the Netherlands and Luxembourg between 1992 and 1996. Patient poor-response characteristics were: genotype 1 (69%), HCV RNA above 2 x 10(6) copies/ml (55%) and cirrhosis (38%). Patients were randomized to 6 months combination therapy with interferon alpha-2b (3 MU tiw) and ribavirin (1000-1200 mg/day), 6 months ribavirin monotherapy (1000-1200 mg/day) or 6 months ribavirin placebo. The study was double blinded for the ribavirin/placebo component. One patient did not fit the entry criteria, and 3 did not start. All 117 patients who received at least one dose of treatment were included in the intention to treat analysis. RESULTS: At the end of treatment, HCV RNA was undetectable in 35% of patients on combination therapy and in none of the patients treated with ribavirin monotherapy or placebo. The sustained virological response rate at 6 months after therapy was 15% for patients treated with interferon and ribavirin.During the 6 months treatment period 13% of patients on interferon ribavirin combination therapy, 13% of patients on ribavirin monotherapy and 11% of patients on placebo withdrew due to side effects or noncompliance. At 24 weeks of treatment the mean Hb level was 85% of the baseline value, which means a mean decrease from 9.1 mmol/l to 7.8 mmol/l. The Hb levels at the end of treatment were not significantly different from patients treated with ribavirin monotherapy (p = 0.76). End of treatment WBC was significantly lower in patients treated with combination therapy, compared to ribavirin (p < 0.01) as well as for patients treated with ribavirin monotherapy compared to placebo (p < 0.01). DISCUSSION: This belated report on the only placebo controlled study of interferon ribavirin combination therapy in non responders to standard doses of interferon monotherapy documents the effectiveness, be it limited, of this approach as well as the dynamics of the effects on blood counts. [less ▲]

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See detailDaily induction combination treatment with alpha 2b interferon and ribavirin or standard combination treatment in naive chronic hepatitis C patients. A multicentre randomized controlled trial
Van Vlierberghe, H.; Leroux-Roels, G.; Adler, M. et al

in Journal of Viral Hepatitis (2003), 10(6), 460-466

The standard treatment for patients with chronic hepatitis C is a 6-12-month combination therapy with interferon alpha and ribavirin. Induction treatment could result in a faster early decline of the ... [more ▼]

The standard treatment for patients with chronic hepatitis C is a 6-12-month combination therapy with interferon alpha and ribavirin. Induction treatment could result in a faster early decline of the hepatitis C virus (HCV) load and a better response rate. Naive chronically infected HCV patients (n = 454) were randomized into two arms to receive either induction treatment with interferon alpha 2b 5 million units (MU) subcutaneously (s.c.) daily during a period of 8 weeks (arm A); or treatment with interferon alpha 2b 5 MU s.c. three times a week (TIW) for a period of 8 weeks (arm B). After week 8, interferon treatment in both arms was 3 MU s.c. TIW for a total period of 12 months. In both arms, ribavirin (1000-1200 mg orally per day) was added at week 4. Induction treatment resulted in a higher virological response at week 8 of treatment (66%vs 47%; P < 0.01). However, response at the end of treatment and at 6 months follow-up was not different (53%vs 50%, 41%vs 33%). The occurrence of adverse events and the drop-out rate were similar in both arms. Although an early virological response is observed more frequently in the induction treatment, end of treatment response and sustained responses did not differ. [less ▲]

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See detailAdherence to various host cell lines of Mycoplasma bovis strains differing in pathogenic and cultural features
Thomas, Anne; Sachse, Konrad; Dizier, Isabelle ULg et al

in Veterinary Microbiology (2003), 91(2-3), 101-113

Mycoplasma bovis is known to be responsible for pneumonia and arthritis in calves, as well as mastitis in dairy cows. Despite clear evidence of its pathogenic potential, little is known about mechanisms ... [more ▼]

Mycoplasma bovis is known to be responsible for pneumonia and arthritis in calves, as well as mastitis in dairy cows. Despite clear evidence of its pathogenic potential, little is known about mechanisms of cytadherence and the molecular factors involved. The purpose of this work was to compare adherence rates of M. bovis field strains to different host cell lines and study the effects of cloning and sub-culturing M. bovis strains on their adherence properties. Eighteen metabolically labeled M. bovis strains isolated from different pathological backgrounds were examined in adherence trials using four different host cell lines, i.e. embryonic bovine lung (EBL), embryonic bovine trachea (EBTr), Madin Darby bovine kidney (MDBK) and rabbit kidney (RK) cells. Although large interstrain variations in adherence rates (3.4-19.1%) were measured they could not be correlated to the pathological background (pneumonia, arthritis or mastitis). Adherence rates to the fibroblast cell line (EBTr) were significantly lower than those to the three epithelial cell lines (EBL, MDBK and RK). The only non-pathogenic strain (221/89) exhibited lower adherence rates than three isolates from clinical mastitis. Interestingly, adherence rates were significantly reduced after in vitro passaging. In contrast, no effect of single cloning of strains on adherence was observed. There was no general correlation between expression of variable surface proteins (Vsps) as monitored by immunoblotting and adherence rates, although alterations in Vsp expression profiles were seen as a consequence of passaging. As there is probably a large number of adhesins, variable and non-variable, on the surface of M. bovis cells the issue is very complex, and the most active components have yet to be identified. [less ▲]

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See detailNew or interesting lichens and lichenicolous fungi from Belgium, Luxembourg and northern France. IX.
Sérusiaux, Emmanuël ULg; Diederich, Paul; Ertz, Damien et al

in Lejeunia : Revue de Botanique (2003), 173

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See detailLes chitosanes – nouveaux adjuvants pour la vaccination par voie muqueuse chez les animaux
Gogev, S.; Versali, Marie-France ULg; Thiry, Etienne ULg

in Annales de Médecine Vétérinaire (2003), 147(5, OCT-NOV), 343-350

The advantage of mucosal vaccination is the induction of an immune response at entry sites of pathogens. Because vaccines alone are poorly bioavailable after mucosal administration, they need to be co ... [more ▼]

The advantage of mucosal vaccination is the induction of an immune response at entry sites of pathogens. Because vaccines alone are poorly bioavailable after mucosal administration, they need to be co-administered with penetration enhancers, or adjuvants. Numerous studies have demonstrated that chitosans and their derivatives are safe and effective mucosal absorption enhancers of hydrophylic macromolecules such as peptides and proteins. Chitosan is a cationic polysaccharide derived from chitin present in the covering layer of arthropods and in the cell walls of many fungi. Association of vaccines to chitosans, their derivatives or some of their particulate systems, such as nano- and microparticles, has also shown to enhance antigen uptake by mucosal lymphoid tissues, thereby inducing mucosal and systemic immune responses against these antigens. Chitosan and its derivatives are promising adjuvants for mucosal vaccine delivery in animals. [less ▲]

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See detailSubocclusion colique precoce apres traitement d'une maladie de Crohn refractaire active par infliximab.
Belaiche, Jacques ULg; Louis, Edouard ULg

in Gastroentérologie Clinique et Biologique (2003), 27(11), 1045-7

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See detailControl of ordered mesoporous molecular sieves synthesis using non-ionic surfactants by incorporation of transition metal ions in the micellar solution
Léonard, Alexandre ULg; Blin, Jean-Luc; Herrier, Gontran et al

in Studies in Surface Science and Catalysis (2003), 146

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See detailChance in biology – Using probability to explore nature (M. Denny, S. Gaines).
Bogaert, Jan ULg

in Acta Biotheoretica (2003), 51(1), 55-57

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See detailRivers, chemical weathering and Earth's climate
Dupre, B.; Dessert, C.; Oliva, P. et al

in Comptes Rendus Geoscience (2003), 335(16), 1141-1160

We detail the results of recent studies describing and quantifying the large-scale chemical weathering of the main types of continental silicate rocks: granites and basalts. These studies aim at ... [more ▼]

We detail the results of recent studies describing and quantifying the large-scale chemical weathering of the main types of continental silicate rocks: granites and basalts. These studies aim at establishing chemical weathering laws for these two lithologies, describing the dependence of chemical weathering on environmental parameters, such as climate and mechanical erosion. As shown within this contribution, such mathematical laws are of primary importance for numerical models calculating the evolution of the partial pressure of atmospheric CO2 and the Earth climate at geological timescales. The major results can be summarized as follow: (1) weathering of continental basaltic lithologies accounts for about 30% of the total consumption of atmospheric CO2 through weathering of continental silicate rocks. This is related to their high weatherability (about eight times greater than the granite weatherability); (2) a simple weathering law has been established for basaltic lithologies, giving the consumption of atmospheric CO2 as a function of regional continental runoff, and mean annual regional temperature; (3) no such simple weathering law can be proposed for granitic lithologies, since the effect of temperature can only be identified for regions displaying high continental runoff; (4) a general law relating mechanical erosion and chemical weathering has been validated on small and large catchments. The consequences of these major advances on the climatic evolution of the Earth are discussed. Particularly, the impacts of the onset of the Deccan trapps and the Himalayan orogeny on the global carbon cycle are reinvestigated. (C) 2003 Academie des sciences. Published by Elsevier SAS. All rights reserved. [less ▲]

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See detailUltrasound appearance of bowel wall in Wolman's disease.
NCHIMI LONGANG, Alain ULg; Rausin, Leon; Khamis, Jamil

in Pediatric Radiology (2003), 33(4), 284-5

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