References of "2003"
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See detailNumerical mdeling of hydro-mechanical fracture behaviour
Guiducci, Chiara; Collin, Frédéric ULg; Radu, Jean-Pol ULg et al

Conference (2003)

A numerical approach for modeling coupled Hydro-Mechanical fracture behavior in 2D is presented in this paper. This approach accounts for the strong dependence of the flow characteristics on fracture ... [more ▼]

A numerical approach for modeling coupled Hydro-Mechanical fracture behavior in 2D is presented in this paper. This approach accounts for the strong dependence of the flow characteristics on fracture apertures and offers an anisotropic description of the flow propagation in the fracture. An interface finite element and a constitutive model are developed . In order to validate the applicability of the model to general geomechanic problems, 2D simulations were performed. Results show the good application of the mathematical model and the fundamental hydraulic role played by the fractures. [less ▲]

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See detailDevelopment of pure prolactin receptor antagonists
Bernichtein, Sophie; Kayser, Christine; Dillner, Karin et al

in Journal of Biological Chemistry (2003), 278(38), 35988-99

Prolactin (PRL) promotes tumor growth in various experimental models and leads to prostate hyperplasia and mammary neoplasia in PRL transgenic mice. Increasing experimental evidence argues for the ... [more ▼]

Prolactin (PRL) promotes tumor growth in various experimental models and leads to prostate hyperplasia and mammary neoplasia in PRL transgenic mice. Increasing experimental evidence argues for the involvement of autocrine PRL in this process. PRL receptor antagonists have been developed to counteract these undesired proliferative actions of PRL. However, all forms of PRL receptor antagonists obtained to date exhibit partial agonism, preventing their therapeutic use as full antagonists. In the present study, we describe the development of new human PRL antagonists devoid of agonistic properties and therefore able to act as pure antagonists. This was demonstrated using several in vitro bioassays, including highly sensitive assays able to detect extremely low levels of receptor activation. These new compounds also act as pure antagonists in vivo, as assessed by analyzing their ability to competitively inhibit PRL-triggered signaling cascades in various target tissues (liver, mammary gland, and prostate). Finally, by using transgenic mice expressing PRL specifically in the prostate, which exhibit constitutively activated signaling cascades paralleling hyperplasia, we show that these new PRL analogs are able to completely revert PRL-activated events. These second generation human PRL antagonists are good candidates to be used as inhibitors of growth-promoting actions of PRL. [less ▲]

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See detailBelgian and Chinese Crop Growth Monitoring Systems: comparison, adaptation and improvement – An introduction
Tychon, Bernard ULg; Ozer, Pierre ULg; Pêcheur, Céline et al

in Tychon, Bernard (Ed.) Belgian and Chinese Crop Growth Monitoring Systems: comparison, adaptation and improvement (2003)

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See detailThe crystal chemistry of lithium in the alluaudite structure
Hatert, Frédéric ULg

Conference (2003)

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See detailLes traitements futurs en allergologie chez le cheval
Bureau, Fabrice ULg; Lekeux, Pierre ULg

in Congrès de l'Association Vétérinaire Equine Française (AVEF) (2003)

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See detailEffet de la durée d’application d’un stimulus gravitationnel sur la formation de bois de tension et de bois opposé dans de jeunes pousses de peuplier (Populus euramericana cv ‘Ghoy’)
Jourez, Benoît ULg; Avella-Shaw, Thomas

in Annals of Forest Science : a Multidisciplinary and International Journal (2003), 60

De jeunes pousses de Peuplier Ghoy ont été maintenues artificiellement inclinées pendant des durées croissantes, afin d’induire la formation de tissus de bois de tension et de bois opposé en réaction au ... [more ▼]

De jeunes pousses de Peuplier Ghoy ont été maintenues artificiellement inclinées pendant des durées croissantes, afin d’induire la formation de tissus de bois de tension et de bois opposé en réaction au stimulus gravitationnel. Il apparaît que ces pousses sont susceptibles de percevoir et de réagir à un stimulus extrêmement bref à l’échelle d’une période de végétation. Après un temps de présentation de 6 heures, l’ensemble des pousses ont formé un arc de bois opposé. Toutefois, sur la face supérieure, un temps compris entre 24 et 48 heures est nécessaire pour qu’elles perçoivent la modification de leur état d’équilibre et se mettent à former du bois de tension. Après un temps de latence de 48 heures, la formation de fibres gélatineuses est déjà observée sur la face supérieure des tiges. L’augmentation de la durée du stimulus a des répercussions sur le nombre de fibres gélatineuses et sur l’angle d’ouverture de l’arc de bois de tension. Sur la face inférieure, les fibres de bois opposé se forment à un rythme moins soutenu, conduisant à une excentricité de la moelle dans la section de la tige. Le redressement des pousses est effectif après une durée de stimulus comprise entre 4 et 8 jours. [less ▲]

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See detailCytokinin levels in leaves, leaf exudate and shoot apical meristem of Arabidopsis thaliana during floral transition
Corbesier, Laurent; Prinsen, Els; Jacqmard, Annie ULg et al

in Journal of Experimental Botany (2003), 54(392), 2511-2517

Understanding the complete picture of floral transition is still impaired by the fact that physiological studies mainly concern plant species whose genetics is poorly known, and vice versa. Arabidopsis ... [more ▼]

Understanding the complete picture of floral transition is still impaired by the fact that physiological studies mainly concern plant species whose genetics is poorly known, and vice versa. Arabidopsis thaliana has been successfully used to unravel signalling pathways by genetic and molecular approaches, but analyses are still required to determine the physiological signals involved in the control of floral transition. In this work, the putative role of cytokinins was investigated using vegetative plants of Arabidopsis (Columbia) induced to flower synchronously by a single 22 h long day. Cytokinins were analysed in leaf extracts, leaf phloem exudate and in the shoot apical meristem at different times during floral transition. It was found that, in both the leaf tissues and leaf exudate, isopentenyladenine forms of cytokinins increased from 16 h after the start of the long day. At 30 h, the shoot apical meristem of induced plants contained more isopentenyladenine and zeatin than vegetative controls. These cytokinin increases correlate well with the early events of floral transition. [less ▲]

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See detailL’Étrenne des Lumières. Trente ans de prédictions dans l’Almanach de Liège
Droixhe, Daniel ULg

in Lüsebrink, H.-J.; Mix, Y.-G.; Mollier, J.-Y. (Eds.) et al Les lectures du peuple en Europe et dans les Amériques (XVIIe au XXe siècle) (2003)

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See detailSimenon, le roman et l'Histoire
Denis, Benoît ULg

in Dumortier, Jean-Louis (Ed.) Le Roman de Simenon. Pedigree : entre réalité et fiction (2003)

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See detailEvaluation de la Convention Premier Emploi - Analyse économique
Bay, Christelle; Fonder, Muriel; Lejeune, Bernard ULg et al

Report (2003)

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See detailTandem high-dose therapy (HDT) for multiple myeloma: recombinant human erythropoietin therapy given between first and second HDT allows second peripheral blood stem cell transplantation without red blood cell transfusion.
Baron, Frédéric ULg; Frere, Pascale ULg; Fillet, Georges ULg et al

in British Journal of Haematology (2003), 123(1), 103-5

We evaluated the ability of recombinant human erythropoietin (rHuEpo) therapy, given before high-dose therapy (HDT), to allow autologous peripheral blood stem cell transplantation (PBSCT) without red ... [more ▼]

We evaluated the ability of recombinant human erythropoietin (rHuEpo) therapy, given before high-dose therapy (HDT), to allow autologous peripheral blood stem cell transplantation (PBSCT) without red blood cell (RBC) transfusions. Eleven multiple myeloma patients underwent tandem HDT and autologous PBSC, receiving 500 U/kg/week rHuEpo from d 30 after initial transplant. Haemoglobin levels were 9.5 +/- 1.1 g/dl and 12.5 +/- 0.9 g/dl at the first and second transplant respectively (P < 0.001). RBC transfusions were required for 10/11 patients for the first transplant versus 1/11 for the second (P < 0.001). To conclude, a short course of rHuEpo therapy before HDT facilitates the performance of an autologous transplant without RBC transfusions. [less ▲]

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See detailL'image du mois. Sous le pont myocardique coule la coronaire.
ROUSSEAU, Anne-Françoise ULg; MIEVIS, Eric

in Revue Médicale de Liège (2003), 58(10), 601-604

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See detailTIMP-2 and PAI-1 mRNA levels are lower in aneurysmal as compared to athero-occlusive abdominal aortas.
Defawe, Olivier D; Colige, Alain ULg; Lambert, Charles ULg et al

in Cardiovascular Research (2003), 60(1), 205-13

OBJECTIVE: Significant alterations of the vascular wall occurs in abdominal aortic aneurysm (AAA) and atherosclerotic occlusive disease (AOD) that ultimately may lead to either vascular rupture or ... [more ▼]

OBJECTIVE: Significant alterations of the vascular wall occurs in abdominal aortic aneurysm (AAA) and atherosclerotic occlusive disease (AOD) that ultimately may lead to either vascular rupture or obstruction. These modifications have been ascribed to one or a group of proteases, their inhibitors or to the matrix macromolecules involved in the repair process without considering the extent of the observed variations. METHODS: The mRNA steady-state level of a large spectrum of proteolytic enzymes (matrix metalloproteinases: MMP-1, -2, -3, -8, -9, -11, -12, -13, -14; urokinase plasminogen activator: u-PA), their physiological inhibitors (tissue inhibitors of MMPs: TIMP-1, -2, -3; plasminogen activator inhibitor: PAI-1) and that of structural matrix proteins (collagens type I and III, decorin, elastin, fibrillins 1 and 2) was determined by RT-PCR made quantitative by using a synthetic RNA as internal standard in each reaction mixture. The profile of expression was evaluated in AAA (n=7) and AOD (n=5) and compared to non-diseased abdominal (CAA, n=7) and thoracic aorta (CTA, n=5). RESULTS: The MMPs -8, -9, -12 and -13 mostly associated with inflammatory cells were not or barely detected in CAA and CTA while they were largely and similarly expressed in AAA and AOD. Expression of protease inhibitors or structural proteins were only slightly increased in both pathological conditions with the exception of elastin which was reduced. The main significant difference between AAA and AOD was a lower expression of TIMP-2 and PAI-1 in the aneurysmal lesions. CONCLUSIONS: The remodeling of the aortic wall in AAA and AOD involves gene activation of a large and similar spectrum of proteolytic enzymes while the expression of two physiological inhibitors, TIMP-2 and PAI-1, is significantly lower in AAA compared to AOD. The repair process in the aneurysmal disease seems similar to that of the occlusive disease. [less ▲]

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See detailLa responsabilité civile du commissaire
Thirion, Nicolas ULg; Balestra, Claudio

in La responsabilité civile, pénale et disciplinaire du réviseur d'entreprises (2003)

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See detailHet vrij verkeer van beslissingen binnen de Europese Unie : toepassing op het arbeidsrechtelijk contentieux
Wautelet, Patrick ULg

in de Leval, Georges (Ed.) Espace judiciaire et social européen (2003)

In this paper, written with Prof. Marta Pertegás Sender, we give an overview of the achievements made within the EU in securing the mutual recognition and enforcement of court decisions issued in ... [more ▼]

In this paper, written with Prof. Marta Pertegás Sender, we give an overview of the achievements made within the EU in securing the mutual recognition and enforcement of court decisions issued in employment disputes. Particular attention is given to the special regime of employment disputes under the 1968 Brussels Convention and the Regulation 44/2001. [less ▲]

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See detailMetabolising risk: food scares and the un/re-making of Belgian beef
Stassart, Pierre M ULg; Whatmore, Sarah J.

in Environment & Planning A (2003), 35

In this paper we explore the event of foodscares as an example of what Callon calls 'hot situations', in which the landscape of competing knowledge claims is at its most molten, and alternative production ... [more ▼]

In this paper we explore the event of foodscares as an example of what Callon calls 'hot situations', in which the landscape of competing knowledge claims is at its most molten, and alternative production and consumption practices galvanise new modes of sense-making against the market and state-sanctioned rationalities of industrialisation. Through a case study of the Belgian cooperative Coprosain and its meat products, we examine the 'stuff' of food as a ready messenger of connectedness and affectivity in which 'risk' is transacted as a property both of the growing distance between the spaces of production and consumption and of the enduring metabolic intimacies between human and nonhuman bodies. [less ▲]

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See detailFrom Community Sanctions to Restorative Justice. The Belgian example.
Lauwaert, Katrien ULg; Peters, Tony; Aertsen, Ivo et al

in Annual Report for 2002 and Resources Material Series N°61 (2003)

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See detailIncidental control of rosacea by somatostatin.
Pierard, Claudine ULg; Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(3), 249-51

BACKGROUND: The precise pathomechanism of rosacea remains elusive. The disease commonly requires long-term treatments using topical or oral therapies. OBJECTIVE: This report presents incidental findings ... [more ▼]

BACKGROUND: The precise pathomechanism of rosacea remains elusive. The disease commonly requires long-term treatments using topical or oral therapies. OBJECTIVE: This report presents incidental findings about the possible modulatory role of somatostatin in the outcome of rosacea. METHOD: Four patients presenting long-standing recalcitrant facial rosacea were treated with octreotide for diabetic retinopathy. RESULTS: Rosacea improved rapidly and even cleared without any recurrence in 3 of the patients. CONCLUSION: The beneficial effect might be attributed to inhibitory actions on the sebaceous gland, the neovascularization and/or on the inflammatory process. [less ▲]

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