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See detailEvolutionary ecology of paedomorphosis in the Alpine newt Triturus alpestris
Denoël, Mathieu ULg

Conference (2003)

Paedomorphosis, in which individuals retain ancestral characteristics in the adult stage, is widespread in newts and salamanders and is suspected to play an important role in evolution. In some species ... [more ▼]

Paedomorphosis, in which individuals retain ancestral characteristics in the adult stage, is widespread in newts and salamanders and is suspected to play an important role in evolution. In some species, paedomorphosis is facultative with some individuals skipping the metamorphic stage. Dimorphic populations of the Alpine newt inhabit a large variety of aquatic habitats such as permanent lakes and temporary ponds. The aim of this study was to determine the benefits of the alternatives in these different habitats. To this end, I focused on resource partitioning, energy intake, body condition and age structures in different populations composed of the two morphs. In deep lakes, there was a substantial trophic differentiation between morphs. Paedomorphs primarily preyed on plankton whereas metamorphs foraged on terrestrial invertebrates that fell to the water surface. By reducing competition, resource partitioning may contribute to the coexistence of the alternative morphs in heterogeneous habitats. On the contrary, in a small pond, resource use was similar in the two morphs. Maturity is reached earlier in the paedomorphs from this small pond than in metamorphs (progenetic process), favoring then a rapid turn-over of the population, while similar gonadal development was observed in one of the deep lakes (neotenic process). Body condition was generally higher in paedomorphs than in metamorphs in each studied population. These results show that facultative paedomorphosis is adaptive in varied habitats, but that different factors may favor it depending of the characteristics of the environment. Paedomorphic phenotypes can thus be selected in low altitude productive ponds and high altitude oligotrophic lakes. [less ▲]

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See detailThe use of blood pepsinogen as a biomarker of the integrity of the porcine gastric mucosa. 2. Measurements of blood pepsinogen and its usefull in the detection of gastric diseases
Banga-Mboko, Henri; Godeau, Jean-Marie ULg; Drion, Pierre ULg et al

in Annales de Médecine Vétérinaire (2003), 147(2, APR-MAY), 95-104

Pepsinogen is one component of the gastric juice which participes in the digestion. This macromolecule enters the blood circulation in a small measurable quantities in healthy subjects. Therefore, blood ... [more ▼]

Pepsinogen is one component of the gastric juice which participes in the digestion. This macromolecule enters the blood circulation in a small measurable quantities in healthy subjects. Therefore, blood pepsinogen is claimed to be an indicator of the integrity of the gastric mucosa. This paper was written to review the use of porcine in the diagnostic of stomach ulcers and Hyostrongylus rubidus infection. The methods of measurement of blood pepsinogen and the diagnostic values are discussed. [less ▲]

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See detailA conceptual framework to design and support self-directed learning in a blended learning program. A case-stydy: the DES-TEF
Denis, Brigitte ULg

in Journal of Educational Media (2003), 28(2-3), 115-127

This paper relates different strategies developed in order to support the learning process in a blended learning programme involving adults from different backgrounds who are interested in the use of ... [more ▼]

This paper relates different strategies developed in order to support the learning process in a blended learning programme involving adults from different backgrounds who are interested in the use of Information and Communication Technologies for Education (ICTE). Referring to Carré & Pearn’s model of the seven pillars of self-learning, the author describes some principles, tools and resources that have been developed within the framework of a postgraduate diploma and that could be extended to similar adult training programmes. [less ▲]

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See detailAutonoos : Le grec ancien pour grands débutants. Volume 2
Renaud, Jean-Michel ULg; Wathelet, Paul ULg

Book published by C.I.P.L. (2003)

L’ouvrage comporte six annexes : les temps primitifs des verbes réputés irréguliers en grec classique, ces temps primitifs sont sans doute pour la première fois expliqués, dans la mesure du possible, par ... [more ▼]

L’ouvrage comporte six annexes : les temps primitifs des verbes réputés irréguliers en grec classique, ces temps primitifs sont sans doute pour la première fois expliqués, dans la mesure du possible, par l’histoire de la langue ; la formation des noms et des adjectifs, selon les règles d’évolution de la langue ; les usages principaux des particules grecques, exemples à l’appui ; les formes du duel ; quelques règles de prosodie et de métrique ; et enfin une dernière annexe, beaucoup plus importante quant à son ampleur, qui fournit les principales caractéristiques des dialectes littéraires (langue épique, éolien oriental, dorien de la lyrique et ionien oriental), avec de nouveau des extraits d’auteurs, introduits, commentés (avec le vocabulaire et la justification des formes) et traduits. [less ▲]

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See detailEffect of induction of late embryonic mortality on plasma profiles of pregnancy associated glycoprotein 1 in heifers
Szenci, Otto; Beckers, Jean-François ULg; Sulon, Joseph ULg et al

in Veterinary Journal (2003), 165(3), 307-313

Inoculation with Actinomyces pyogenes and administration of prostaglandin (PG) F-2alpha were used to induce late embryonic mortality (LEM) in heifers (n = 8) on Days 30-38 of pregnancy in order to compare ... [more ▼]

Inoculation with Actinomyces pyogenes and administration of prostaglandin (PG) F-2alpha were used to induce late embryonic mortality (LEM) in heifers (n = 8) on Days 30-38 of pregnancy in order to compare the profile for bovine pregnancy associated glycoprotein 1 (PAG1), progesterone and 15-keto-13,14-dihydro-PGF(2alpha) (PGFM). Two pregnant heifers were used as controls. Inoculation into the uterine body caused LEM, as established by ultrasonography in each heifer within 24 h of treatment. When the inoculum was injected into the first part of the cervix, LEM occurred in one of two heifers (Heifer A) between 48 and 72 h after treatment. Similarly, PGF(2alpha) treatment caused LEM in three of four heifers. In six of eight heifers, PAG1 started to decrease steadily when it was accompanied by the subsequent death of the embryo. Inoculation through the cervix caused luteolysis in three of four heifers within 6-10 days after induction. After induction of LEM, PGFM concentrations showed a two to 3.8 fold increase in three of four heifers during the following six days, and from that time changed within normal ranges. The results of this study indicate that a PAG1 assay may provide an alternative method to ultrasonography for determining LEM in the cow. [less ▲]

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See detailİzmir Gezisi: Antoine Galland'ın Bir Elyazması (1678)
Galland, Antoine; Bauden, Frédéric ULg; Üyepazarcı, Erol

Book published by İzmir Büyükşehir Belediyesi Kültür Yayını (2003)

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See detailAdaptation of the Heilongjiang Province Institute of Meteorological Sciences “Crop Growth Dynamic Model” to the Belgian conditions.
Weinzaepflen, Emmanuelle; Ozer, Pierre ULg; Tychon, Bernard ULg

in Tychon, Bernard (Ed.) Belgian and Chinese Crop Growth Monitoring Systems: comparison, adaptation and improvement (2003)

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See detail3-Isopropylamino-7-nitro-1,4,2-benzodithiazine 1,1-dioxide
Dupont, L.; Somers, F.; De Tullio, Pascal ULg et al

in Acta Crystallographica (2003)

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See detailCompte rendu de l'ouvrage de S. Dawans : Le spectre de la honte
Cormann, Grégory ULg

in Archives de Philosophie (2003), 66(2), 340-342

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See detailRéceptions, études et usages de l’univers rabelaisien aux Refuges protestants
Donneau, Olivier ULg

in Bost, Hubert; Lauriol, Claude (Eds.) Refuge et Désert : l'évolution théologique des huguenots de la Révocation de l’édit de Nantes à la Révolution française, Actes du colloque du Centre d'étude du XVIIIe siècle. Montpellier, 18-19-20 janvier 2001 (2003)

Huguenot Refugees (1685-1750) almost have a monopoly on the image of Rabelais. They find in the works of Rabelais an echo of their own history.

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See detailDoes Export Controls Regimes could Contribute to Counter the Acquisition of WMD by Sub-national ?,
Michel, Quentin ULg

in Bulletin de l'Académie Royale des Sciences, des Lettres et des Beaux-Arts de Belgique. Sciences (2003)

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See detailA stepwise approach for chemical risks assessment at the workplace
Mairiaux, Philippe ULg; Balsat, Alain; Dujardin, Marc ULg et al

in Strasser, H.; Kluth, K.; Rausch, H. (Eds.) et al Quality of work and products in enterprises of the future (2003)

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See detailGrowth hormone (GH) secretion in patients with childhood-onset GH deficiency: Retesting after one year of therapy and at final height
Thomas, Muriel; Massa, Guy; Maes, Maes et al

in Hormone Research (2003), 59(1), 7-15

Background. Recent studies have shown that many patients treated with growth hormone (GH) during childhood because of idiopathic GH deficiency (GHD) are no longer GH deficient when retested after ... [more ▼]

Background. Recent studies have shown that many patients treated with growth hormone (GH) during childhood because of idiopathic GH deficiency (GHD) are no longer GH deficient when retested after cessation of GH therapy when final height is achieved. These patients are labelled as transient GHD. We hypothesized that normalization of GH secretion in transient GHD could occur earlier during the course of GH treatment, which could allow earlier cessation of GH treatment. Methods: In a retrospective study, GH secretion was re-evaluated after cessation of GH treatment at final height in 43 patients diagnosed during childhood as idiopathic GHD 10 with multiple pituitary hormonal deficiencies (MPHD) and 33 with isolated GHD ([sGHD]). In a prospective study, GH secretion was re-assessed after interruption of GH treatment given for 1 year in 18 children with idiopathic GHD (2 MPHD, 16 IsGHD). GH secretion was evaluated by glucagon or insulin stimulation tests. Results: In the retrospective study, all the 10 patients with MPHD and 64% of the 33 patients with IsGHD were still deficient at re-evaluation using the paediatric criteria to define GHD (GH peak < 10 ng/ml at provocative test). The proportion of persisting deficiency was greater in patients with complete IsGHD (86%, 12/14 patients) than in patients with partial IsGHD (47%, 9/19 patients). With the criteria proposed in adulthood (GH peak <3 ng/ml), all the 10 patients with MPHD were still considered to be deficient. In contrast, only 15% (5/33 patients) with IsGHD had a maximal GH value < 3 ng/ml (36% of the 14 patients with complete IsGHD and none of the 19 patients with partial IsGHD). In the prospective study, after interruption of GH therapy given for 1 year, the 2 patients with MPHD were still GHD at re-evaluation and they resumed GH treatment. Among the 16 patients with IsGHD, 13 (81%) were still deficient (peak response < 10 ng/ml) after 1 year. Two of the 3 patients in whom GHD was not confirmed at retesting after 1 year GH showed again a deficient response at second retesting. Conclusions: Although many patients diagnosed with IsGHD during childhood have a normalized GH secretory capacity when retested during adulthood, early retesting after interruption of GH treatment given for 1 year during childhood does not enable to determine if GH therapy has to be discontinued before cessation of growth. Copyright (C) 2003 S. Karger AG, Basel. [less ▲]

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See detailVTT benchmark: Application of the restoring force surface method
Kerschen, Gaëtan ULg; Lenaerts, V.; Golinval, Jean-Claude ULg

in Mechanical Systems & Signal Processing (2003), 17(1), 189-193

The restoring force surface method is an efficient and reliable technique for the identification of non-linear mechanical systems. The objective of this paper is to demonstrate its utility for the ... [more ▼]

The restoring force surface method is an efficient and reliable technique for the identification of non-linear mechanical systems. The objective of this paper is to demonstrate its utility for the identification of the VTT benchmark. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailRegulation of neural markers nestin and GFAP expression by cultivated bone marrow stromal cells.
Wislet-Gendebien, Sabine ULg; Leprince, Pierre ULg; Moonen, Gustave ULg et al

in Journal of Cell Science (2003), 116(Pt 16), 3295-302

Bone marrow stromal cells can differentiate into many types of mesenchymal cells, i.e. osteocyte, chondrocyte and adipocyte, but can also differentiate into non-mesenchymal cells, i.e. neural cells under ... [more ▼]

Bone marrow stromal cells can differentiate into many types of mesenchymal cells, i.e. osteocyte, chondrocyte and adipocyte, but can also differentiate into non-mesenchymal cells, i.e. neural cells under appropriate in vivo experimental conditions (Kopen et al., 1999; Brazelton et al., 2000; Mezey et al., 2000). This neural phenotypic plasticity allows us to consider the utilization of mesenchymal stem cells as cellular material in regenerative medicine. In this study, we demonstrate that cultured adult rat stromal cells can express nestin, an intermediate filament protein predominantly expressed by neural stem cells. Two factors contribute to the regulation of nestin expression by rat stromal cells: serum in the culture medium inhibits nestin expression and a threshold number of passages must be reached below which nestin expression does not occur. Only nestin-positive rat stromal cells are able to form spheres when they are placed in the culture conditions used for neural stem cells. Likewise, only nestin-positive stromal cells are able to differentiate into GFAP (glial fibrillary acidic protein)-positive cells when they are co-cultivated with neural stem cells. We thus demonstrated that adult rat stromal cells in culture express nestin in absence of serum after passaging the cells at least ten times, and we suggest that nestin expression by these cells might be a prerequisite for the acquisition of the capacity to progress towards the neural lineage. [less ▲]

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See detailBehavioral characterization of acetaldehyde in C57BL/6J mice: Locomotor, hypnotic and ataxic effects
Quertemont, Etienne ULg; Tambour, Sophie ULg; Tirelli, Ezio ULg

in Behavioural Pharmacology (2003), 14(Suppl. 1), 69-69

Acetaldehyde, the first ethanol metabolite, was recently suggested to play a major role in many behavioral effects of ethanol. However, no studies have directly investigated the behavioral effects of ... [more ▼]

Acetaldehyde, the first ethanol metabolite, was recently suggested to play a major role in many behavioral effects of ethanol. However, no studies have directly investigated the behavioral effects of acetaldehyde after acute administration. Therefore, the aim of the present study was to characterize the locomotor, hypnotic and ataxic effects of acetaldehyde in C57BL/6J mice. Various acetaldehyde doses (0-300 mg/kg) were injected intraperitoneally and their effects were investigated with several classical behavioral tests. The locomotor effects of acetaldehyde were measured in standard activity boxes. In addition, the loss of righting reflex was used to assess the hypnotic effects of acetaldehyde. Finally, the ataxic effects of acetaldehyde were studied with the horizontal wire test. The results show that acetaldehyde induced a significant hypolocomotor effect at 170 mg/kg and higher doses. In addition, the hypnotic effects of acetaldehyde were evidenced by a loss of righting reflex in doses between 170 and 300 mg/kg. However, the locomotor and hypnotic effects of acetaldehyde were very brief relative to what is observed after ethanol administration. After 170 mg/kg acetaldehyde, normal activity was recovered in less than 30 minutes and the loss of righting reflex lasted only an average of 6.14 ± 1.29 minutes after the administration of 300 mg/kg acetaldehyde, the highest testable dose before lethality. Ataxic effects were observed with lower doses that did not significantly affect locomotor activity. These results show that acetaldehyde, like ethanol, possesses sedative, hypnotic and ataxic properties and therefore indicate that the first product of ethanol metabolism might be involved in these ethanol effects. [less ▲]

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See detailDesign and methodology of the phase 3 trials for the clinical development of strontium ranelate in the treatment of women with postmenopausal osteoporosis
Meunier, P. J.; Reginster, Jean-Yves ULg

in Osteoporosis International (2003), 14(Suppl. 3), 66-76

The phase 3 program for strontium ranelate, a new oral agent in the treatment of women with postmenopausal osteoporosis, was aimed to assess the efficacy and safety of the daily oral dose of 2 g. This ... [more ▼]

The phase 3 program for strontium ranelate, a new oral agent in the treatment of women with postmenopausal osteoporosis, was aimed to assess the efficacy and safety of the daily oral dose of 2 g. This program was conducted in 12 countries, involved 75 centers, and was structured in 3 studies: FIRST (Fracture International Run-in for Strontium ranelate Trial), SOTI (Spinal Osteoporosis Therapeutic Intervention study) and TROPOS (TReatment Of Peripheral OSteoporosis). FIRST, a run-in open study, was designed to start the normalization of the calcium and vitamin D status of the patients, check all entry criteria, and ensure inclusion of a sufficient number of well-motivated patients in either one of the two therapeutic intervention protocols, SOTI or TROPOS: FIRST included 9,196 patients. SOTI and TROPOS were prospective, randomized, double-blind clinical trials comparing, in two parallel groups, the daily oral dose of 2 g of strontium ranelate with placebo, the patients of both groups receiving calcium and vitamin D according to their own deficiencies. The main objective of SOTI and TROPOS was to demonstrate a reduction in the incidence of postmenopausal women experiencing a new osteoporotic fracture (vertebral fracture in SOTI and nonvertebral fracture in TROPOS) over a 3-year treatment period, the total duration of the studies being 5 years. SOTI included 1,649 women with at least one osteoporotic vertebral fracture at inclusion and a lumbar BMD less than or equal to 0.840 g/cm(2). TROPOS included 5,091 women with a femoral neck BMD less than or equal to 0.600 g/cm(2). The phase 3 program for the clinical development of strontium ranelate in women with postmenopausal osteoporosis is a long-term program with the main statistical analysis after 3 years of treatment. Its aim is to demonstrate the effect of strontium ranelate on the axial and appendicular skeleton as well as its tolerability in osteoporotic patients with replete calcium and vitamin D stores. [less ▲]

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See detailHow ergodic is the fragmentation of the pyridine cation? A maximum entropy analysis
Gridelet, E.; Locht, Robert ULg; Lorquet, Andrée ULg et al

in International Journal of Mass Spectrometry (2003), 228(2-3), 389-402

The kinetic energy released to the C4H4+ and HCN fragments produced by the dissociation of the pyridine ion has been determined by a retarding field technique up to an internal energy of 4eV above the ... [more ▼]

The kinetic energy released to the C4H4+ and HCN fragments produced by the dissociation of the pyridine ion has been determined by a retarding field technique up to an internal energy of 4eV above the reaction threshold. This extends our previous study limited to the metastable domain [Int. J. Mass Spectrom. Ion Process. 185/186/187 (1999) 155]. Retarding potential curves resulting from dissociative photoionization using the He(I), Ne(I), and Ar(II) resonance lines have been analyzed by the maximum entropy method. The comparison between the experimentally measured curves and those calculated for the prior (i.e., most statistical) situation reveals the existence of dynamical constraints that prevent phase space from being fully explored. The "ergodicity index" F(E) that measures the efficiency of phase space sampling as a function of the internal energy E of the molecular ion is found to decrease steadily as a function of E and to level off at a value of about 50% when E greater than or equal to 2.5 eV At these high internal energies where phase space exploration no longer decreases, spontaneous intramolecular vibrational energy redistribution (i.e., resulting from the anharmonicity of the molecular vibrations) is thought to contribute to internal energy randomization to a limited extent only. When the lifetime is short, phase space exploration is believed to result instead from the relaxation of the electronic energy via a cascade of non-radiative transitions, which leads to a great diversity of initial conditions, and thus, contributes to statisticity. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailUtilisation des techniques végétales pour la stabilisation des berges : suivi de chantiers réalisés dans différents types de rivières wallonnes.
Hallot, Eric ULg; Petit, François ULg; Verniers, G. et al

in Evaluer le milieu - Journées des géographes belges (2003)

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