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See detailIncreased mRNA expression of decorin in the prolapsing posterior leaflet of the mitral valve.
Radermecker, Marc ULg; Limet, Raymond ULg; Lapiere, C. M. et al

in Interactive Cardiovascular and Thoracic Surgery (2003), 2(3), 389-94

To improve our understanding of myxomatous degeneration of the valvar tissue as seen in mitral valve prolapse, we have compared the biosynthetic phenotype of the connective tissue cells in myxomatous ... [more ▼]

To improve our understanding of myxomatous degeneration of the valvar tissue as seen in mitral valve prolapse, we have compared the biosynthetic phenotype of the connective tissue cells in myxomatous segments (n=4) resected during surgery with that of homologous segments of normal valves (n=4) harvested in age-matched organ donors. The steady-state level of mRNA for selected extracellular matrix macromolecules and metalloproteinases was assessed by quantitative (internal standard controlled) reverse transcriptase-polymerase chain reaction (RT-PCR). Among the investigated gene products, the decorin mRNA expression was significantly increased in degenerative valve compared with normal tissue (211+/-48 vs. 100+/-70, p<0.02). The level of fibrillin 2 also tended to be increased (194+/-88 vs. 100+/-81, p=0.08). These results suggest that myxomatous valvar tissue is characterized by an overexpression of mRNA for decorin. Owing to the role of this small leucine-rich proteoglycan in the regulation of fibril assembly and stability, this alteration may account for or is a result of a defective organization of the collagen and elastic fibers in this disease and contribute to the intrinsic distensibility and fragility of the myxomatous tissue. [less ▲]

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See detailGrecs et Romains aux prises avec l'histoire, Représentations, récits et idéologie
Longrée, Dominique ULg; Lachenaud, Guy

Book published by Presses universitaires de Rennes (2003)

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See detailEffet de la durée d’application d’un stimulus gravitationnel sur la formation de bois de tension et de bois opposé dans de jeunes pousses de peuplier (Populus euramericana cv ‘Ghoy’)
Jourez, Benoît ULg; Avella-Shaw, Thomas

in Annals of Forest Science : a Multidisciplinary and International Journal (2003), 60

De jeunes pousses de Peuplier Ghoy ont été maintenues artificiellement inclinées pendant des durées croissantes, afin d’induire la formation de tissus de bois de tension et de bois opposé en réaction au ... [more ▼]

De jeunes pousses de Peuplier Ghoy ont été maintenues artificiellement inclinées pendant des durées croissantes, afin d’induire la formation de tissus de bois de tension et de bois opposé en réaction au stimulus gravitationnel. Il apparaît que ces pousses sont susceptibles de percevoir et de réagir à un stimulus extrêmement bref à l’échelle d’une période de végétation. Après un temps de présentation de 6 heures, l’ensemble des pousses ont formé un arc de bois opposé. Toutefois, sur la face supérieure, un temps compris entre 24 et 48 heures est nécessaire pour qu’elles perçoivent la modification de leur état d’équilibre et se mettent à former du bois de tension. Après un temps de latence de 48 heures, la formation de fibres gélatineuses est déjà observée sur la face supérieure des tiges. L’augmentation de la durée du stimulus a des répercussions sur le nombre de fibres gélatineuses et sur l’angle d’ouverture de l’arc de bois de tension. Sur la face inférieure, les fibres de bois opposé se forment à un rythme moins soutenu, conduisant à une excentricité de la moelle dans la section de la tige. Le redressement des pousses est effectif après une durée de stimulus comprise entre 4 et 8 jours. [less ▲]

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See detailClassification des rongeurs
Mignon, Jacques ULg; Hardouin, Jacques

in Bulletin BEDIM (2003), 12(1), 12-13

The note aims at providing the main characteristics of the principal families of rodents relevant to minilivestock.

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See detailCAPRINE ARTHRITIS ENCEPHALITIS VIRUS (CAEV) EXPRESSING THE SIV VPR/VPX GENES INDUCES PROPERTIES SIMILAR TO ANTI-CANCER DRUGS
Bouzar, Amel ULg; Villet, Stéphanie; Morin, Thierry et al

in Bulletin of the Veterinary Institute in Pulawy =Biuletyn Instytutu Weterynarii w Puławach (2003)

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See detailBinding Problem
Sougné, Jacques ULg; Nadel, L.

in Encyclopedia of Cognitive Science (2003)

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See detailCalibration and quality assessment of water vapor radiometer observations using radiosonde GPS and VLBI
Pottiaux, Eric; Becker, M.; Buerki, B. et al

Conference (2003)

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See detailDevelopment and validation of a specific radioimmunoassay for equine osteocalcin
Carstanjen, Bianca; Sulon, Joseph ULg; Banga-Mboko, H. et al

in Domestic Animal Endocrinology (2003), 24(1), 31-41

This study describes for the first time the development and validation of a sensitive and specific radioimmunoassay (RIA) for equine osteocalcin (OC) quantification using purified equine OC as standard ... [more ▼]

This study describes for the first time the development and validation of a sensitive and specific radioimmunoassay (RIA) for equine osteocalcin (OC) quantification using purified equine OC as standard, tracer, and immunogen for antibody formation in rabbits. The assay allowed to measure equine serum OC levels with a sensitivity of 0.2 ng/mL. Immunoreactive serum OC values of clinically normal, different-aged horses ranged from 3.68 to 127.31 ng/mL. Intra- and inter-assay coefficients of variation (CV) were 6.2 and 8.2%, respectively. Serial equine scrum sample dilutions were linear. The recovery of equine OC from equine serum samples ranged from 93.88 to 107.9%. There was a tight correlation between OC values measured with the equine- specific OC RIA and two commercially available bovine-specific OC RIA kits. However, highest serum OC values were obtained with the equine-specific OC RIA. In conclusion, our equine-specific OC RIA is sensitive, linear, accurate, precise, and reproducible. The assay allowed to quantify OC in equine serum samples and might, therefore, be used to monitor equine osteoblast activity associated with bone diseases, exercise, therapy forms or diet. [less ▲]

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See detailLes contradictions de la violence légitime
Verjans, Pierre ULg

in Beaufays, Jean (Ed.) La démocratie après le 11 septembre (2003)

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See detailLeçons de l’éphémère. La Cour d’arbitrage et le "Renouveau’ électoral" – La Cour d’arbitrage et la suspension
Rosoux, Géraldine ULg

in Revue Belge de Droit Constitutionnel (2003)

The articles analyzes the electoral reform of 2003 and points out the competence of the Belgian constitutional Court to suspend legislative norms.

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See detailLa commercialisation des produits éthiques: études de cas dans les secteurs de l'alimentation bio et équitable
Mouchamps, Hugues ULg

Master's dissertation (2003)

Social enterprises commercializing ethical products present shortcomings in their marketing strategies, especially in the place and promotion dimensions.

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See detailEvaluation de la Convention Premier Emploi - Analyse économique
Bay, Christelle; Fonder, Muriel; Lejeune, Bernard ULg et al

Report (2003)

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See detailCompte rendu d’Adrienne et Luc Fontainas, et Émile Van Balberghe, Publications de la Librairie Deman. Bibliographie
Durand, Pascal ULg

in Textyles : Revue des Lettres Belges de Langue Française (2003)

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See detailA conceptual framework to design and support self-directed learning in a blended learning program. A case-stydy: the DES-TEF
Denis, Brigitte ULg

in Journal of Educational Media (2003), 28(2-3), 115-127

This paper relates different strategies developed in order to support the learning process in a blended learning programme involving adults from different backgrounds who are interested in the use of ... [more ▼]

This paper relates different strategies developed in order to support the learning process in a blended learning programme involving adults from different backgrounds who are interested in the use of Information and Communication Technologies for Education (ICTE). Referring to Carré & Pearn’s model of the seven pillars of self-learning, the author describes some principles, tools and resources that have been developed within the framework of a postgraduate diploma and that could be extended to similar adult training programmes. [less ▲]

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See detailAge, sex, and weight at weaning influence organ weight and gastrointestinal development of weanling pigs
Pluske, J. R.; Kerton, D. J.; Cranwell, P. D. et al

in Australian Journal of Agricultural Research (2003), 54(5), 515-527

The present study was designed to determine the interrelationships between sex, weaning age, and weaning weight on aspects of physiological and gastrointestinal development in pigs. Forty-eight Large ... [more ▼]

The present study was designed to determine the interrelationships between sex, weaning age, and weaning weight on aspects of physiological and gastrointestinal development in pigs. Forty-eight Large White x Landrace pigs were used in a factorial arrangement with the respective factors being: age at weaning ( 14 or 28 days), weight at weaning ( heavy or light), sex ( boar or gilt), and time after weaning ( 1, 7, and 14 days). At weaning, 48 pigs were removed from the sow; 16 pigs were then fasted for 24 h before euthanasia for determination of organ weights, gut histology, and enzymology, and 32 pigs were offered a high quality pelleted weaner diet ad libitum for subsequent assessment of organ weights, histology, and enzymology at 7 and 14 days after weaning. On Day 6 and 13 after weaning, 2 pigs from each group had their feed removed, and 24 h later were euthanased and similar measurements were taken. In general, the data highlighted the overall gastrointestinal underdevelopment of pigs weaned at 2 weeks of age and of pigs weaned light-for-age at either 2 or 4 weeks. Heavier body organs, gastrointestinal organs, and accessory digestive organs observed after weaning, except for the spleen, presumably reflected the increase in substrates available for cellular growth as feed intake increased after weaning, and the development of organs required to process this feed. Interestingly, the relative weights (% of liveweight) of the stomach and small intestine and, to a lesser extent, the caecum and colon, were greater in the light, 14-day-old weaned pigs, but these differences diminished with increasing time after weaning. Consistent effects due to age, weight, and sex were not observed for villous height and crypt depth, or for the specific activities of the brush-border and pancreatic enzymes measured. However, increases (P < 0.001) in the activities of maltase (P < 0.001), glucoamylase ( P < 0.001), and sucrase (P = 0.020) ( all expressed per gram of mucosa), and that of trypsin ( per gram of pancreas), occurred by 14 days after weaning. This most likely reflected the inducible nature of these enzymes in response to the increasing intake of substrates provided in the diet. In contrast, the specific activity of lactase declined (P = 0.012) in the first 14 days after weaning. These data suggest that pigs weaned at 2 weeks of age and pigs weaned light-for-age at either 2 or 4 weeks have a less developed gastrointestinal tract, and that its development after weaning might proceed differently to that of pigs weaned older and heavier. [less ▲]

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See detailSoluble transferrin receptor for the evaluation of erythropoiesis and iron status.
Beguin, Yves ULg

in Clinica Chimica Acta (2003), 329(1-2), 9-22

Iron transport in the plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor, the transferrin receptor (TfR). A soluble form of the TfR ... [more ▼]

Iron transport in the plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor, the transferrin receptor (TfR). A soluble form of the TfR (sTfR) has been identified in animal and human serum. Soluble TfR is a truncated monomer of tissue receptor, lacking its first 100 amino acids, which circulates in the form of a complex of transferrin and its receptor. The erythroblasts rather than reticulocytes are the main source of serum sTfR. Serum sTfR levels average 5.0+/-1.0 mg/l in normal subjects but the various commercial assays give disparate values because of the lack of an international standard. The most important determinant of sTfR levels appears to be marrow erythropoietic activity which can cause variations up to 8 times below and up to 20 times above average normal values. Soluble TfR levels are decreased in situations characterized by diminished erythropoietic activity, and are increased when erythropoiesis is stimulated by hemolysis or ineffective erythropoiesis. Measurements of sTfR are very helpful to investigate the pathophysiology of anemia, quantitatively evaluating the absolute rate of erythropoiesis and the adequacy of marrow proliferative capacity for any given degree of anemia, and to monitor the erythropoietic response to various forms of therapy, in particular allowing to predict response early when changes in hemoglobin are not yet apparent. Iron status also influences sTfR levels, which are considerably elevated in iron deficiency anemia but remain normal in the anemia of inflammation, and thus may be of considerable help in the differential diagnosis of microcytic anemia. This is particularly useful to identify concomitant iron deficiency in a patient with inflammation because ferritin values are then generally normal. Elevated sTfR levels are also the characteristic feature of functional iron deficiency, a situation defined by tissue iron deficiency despite adequate iron stores. The sTfR/ferritin ratio can thus describe iron availability over a wide range of iron stores. With the exception of chronic lymphocytic leukemia (CLL) and high-grade non-Hodgkin's lymphoma and possibly hepatocellular carcinoma, sTfR levels are not increased in patients with malignancies. We conclude that soluble TfR represents a valuable quantitative assay of marrow erythropoietic activity as well as a marker of tissue iron deficiency. [less ▲]

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See detailL'Observatoire de la consommation alimentaire
Claustriaux, Jean-Jacques ULg; Cordier, L.; Duquesne, Brigitte ULg et al

in Vers une politique de qualité, à quel prix ? (2003)

Description de l'utilisation d'une base de données relative aux achats de produits alimentaires effectués par des ménages.

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See detailRENO, a European Postmarket Surveillance Registry, confirms effectiveness of coronary brachytheraypy in routine clinical practice.
Coen, V; Serruys, P; Sauerwein, W et al

in International Journal of Radiation, Oncology, Biology, Physics (2003), 55(4), 1019-1026

Purpose: To assess, by a European registry trial, the clinical event rate in patients with discrete stenotic lesions of coronary arteries (de novo or restenotic) in single or multiple vessels (native or ... [more ▼]

Purpose: To assess, by a European registry trial, the clinical event rate in patients with discrete stenotic lesions of coronary arteries (de novo or restenotic) in single or multiple vessels (native or bypass grafts) treated with -radiation. Methods and Materials: Between April 1999 and September 2000, 1098 consecutive patients treated in 46 centers in Europe and the Middle East with the Novoste Beta-Cath System were included in Registry Novoste (RENO). Results: Six-month follow-up data were obtained for 1085 patients. Of 1174 target lesions, 94.1% were located in native vessels and 5.9% in a bypass graft; 17.7% were de novo lesions, 4.1% were restenotic, and 77.7% were in-stent restenotic lesions. Intravascular brachytherapy was technically successful in 95.9% of lesions. Multisegmental irradiation, using a manual pullback stepping maneuver to treat longer lesions, was used in 16.3% of the procedures. The in-hospital rate of major adverse cardiac events was 1.8%. At 6 months, the rate was 18.7%. Angiographic follow-up was available for 70.4% of the patients. Nonocclusive restenosis was seen in 18.8% and total occlusion in 5.7% of patients. A combined end point for late (30–180 days) definitive or suspected target vessel closure was reached in 5.4%, but with only 2% of clinical events. Multivariate analysis was performed for major adverse cardiac events and late thrombosis. Conclusion: Data obtained from the multicenter RENO registry study, derived from a large cohort of unselected consecutive patients, suggest that the good results of recent randomized controlled clinical trials can be replicated in routine clinical practice. © 2003 Elsevier Science Inc. [less ▲]

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