References of "2003"
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See detailL'image du mois. Une varice duodenale compliquant une hypertension portale
Detry, Olivier ULg; Delwaide, Jean ULg; De Roover, Arnaud ULg et al

in Revue Médicale de Liège (2003), 58(11), 657-8

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See detailOMC: An Optical Monitoring Camera for INTEGRAL - Instrument description and performance
Mas-Hesse, J. M.; Gimenez, A.; Culhane, J. L. et al

in Astronomy and Astrophysics (2003), 411(1), 261-268

The Optical Monitoring Camera (OMC) will observe the optical emission from the prime targets of the gammaray instruments onboard the ESA mission INTEGRAL, with the support of the JEM-X monitor in the X ... [more ▼]

The Optical Monitoring Camera (OMC) will observe the optical emission from the prime targets of the gammaray instruments onboard the ESA mission INTEGRAL, with the support of the JEM-X monitor in the X-ray domain. This capability will provide invaluable diagnostic information on the nature and the physics of the sources over a broad wavelength range. Its main scientific objectives are: ( 1) to monitor the optical emission from the sources observed by the gamma- and X-ray instruments, measuring the time and intensity structure of the optical emission for comparison with variability at high energies, and ( 2) to provide the brightness and position of the optical counterpart of any gamma- or X-ray transient taking place within its field of view. The OMC is based on a refractive optics with an aperture of 50 mm focused onto a large format CCD (1024 x 2048 pixels) working in frame transfer mode (1024 x 1024 pixels imaging area). With a field of view of 5degrees x 5degrees it will be able to monitor sources down to magnitude V = 18. Typical observations will perform a sequence of different integration times, allowing for photometric uncertainties below 0.1 mag for objects with V less than or equal to 16. [less ▲]

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See detailLa forêt luxembourgeoise en chiffres. Résultats de l'inventaire forestier national au Grand-Duché de Luxembourg 1998-2000
Rondeux, Jacques ULg; Wagner, M.; Thibaut, André et al

Book published by Administration des Eaux et Forêts du Grand-Duché de Luxembourg - Service de l'Aménagement des Bois et de l'Economie Forestière (2003)

Ce livre brosse un tableau de la forêt luxembourgeoise sur base de données statistiques obtenues grâce au premier Inventaire Forestier National pour le Grand-Duché, réalisé dans un réseau d'observation ... [more ▼]

Ce livre brosse un tableau de la forêt luxembourgeoise sur base de données statistiques obtenues grâce au premier Inventaire Forestier National pour le Grand-Duché, réalisé dans un réseau d'observation permanent d'environ 5.200 placettes. [less ▲]

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See detailDioxin/polychlorinated biphenyl body burden, diabetes and endometriosis: findings in a population-based study in Belgium
Fierens, S.; Mairesse, H.; Heilier, J. F. et al

in Biomarkers : Biochemical Indicators of Exposure, Response, & Susceptibility to Chemicals (2003), 8(6), 529-534

Dioxins and polychlorinated biphenyls (PCBs) are persistent organic pollutants widely distributed in the food chain, which is the main source of human exposure. Their effects on human health at background ... [more ▼]

Dioxins and polychlorinated biphenyls (PCBs) are persistent organic pollutants widely distributed in the food chain, which is the main source of human exposure. Their effects on human health at background exposure levels are still poorly understood. Recent epidemiological evidence suggests a possible association between these pollutants and diabetes. We report here the results of a population-based study in Belgium on 257 (142 women and 115 men) environmentally exposed subjects, including 10 cases of endometriosis and nine cases of diabetes. Seventeen 2,3,7,8-polychlorinated dibenzodioxins/dibenzofurans (PCDD/Fs or dioxins), four coplanar PCBs (International Union of Pure and Applied Chemistry [IUPAC] nos 77, 81, 126 and 169) and 12 PCB markers ( IUPAC nos 3, 8, 28, 52, 101, 118, 138, 153, 180, 194, 206 and 209) were quantified in serum fat from fasting blood samples in order to estimate the body burden of these pollutants. Whilst no difference was found between women with endometriosis and their controls, diabetic patients had significantly increased serum levels of dioxins, coplanar PCBs and the 12 PCB markers. After adjustment for age and other covariates, serum total toxic equivalent activity (sum of PCDD/Fs and coplanar PCBs) and 12 PCB marker concentrations in diabetics were 62% (p=0.0005) and 39% (p=0.0067) higher, respectively, than in controls. The risk of diabetes was significantly increased in subjects in the top decile for adjusted concentrations of dioxins (odds ratio 5.1, 95% confidence interval [CI] 1.18-21.7), coplanar PCBs (odds ratio 13.3, 95% CI 3.31-53.2) or 12 PCB markers (odds ratio 7.6, 95% CI 1.58-36.3). These findings warrant further studies to assess the significance of the associations between diabetes and environmental exposure to polychlorinated pollutants. [less ▲]

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See detailPutative roles of the CNF2 and CDTIII toxins in experimental infections with necrotoxigenic Escherichia coli type 2 (NTEC2) strains in calves
Van Bost, S.; Roels, S.; Oswald, E. et al

in Microbes & Infection (2003), 5(13), 1189-1193

Newborn colostrum-restricted calves were orally inoculated with an Escherichia coli strain, identified originally as non-pathogenic, and into which the plasmid pVir was conjugally transferred. This ... [more ▼]

Newborn colostrum-restricted calves were orally inoculated with an Escherichia coli strain, identified originally as non-pathogenic, and into which the plasmid pVir was conjugally transferred. This resulted in diarrhea, intestinal lesions and extra-intestinal invasion, suggesting that factors affecting these pathogenic properties are located on pVir. In order to analyze the respective roles of the toxins CNF2 and CDTIII in the pathogenesis, colostrum-restricted calves were inoculated with isogenic mutants in the cnf2 and the cdt-III genes. The loss of cnf2 is associated with a reduction in the pathogenicity, since diarrhea does not occur in calves challenged, in spite of successful colonization of the intestine. Nevertheless, the mutant strain remains able to invade the bloodstream and to localize in the internal organs. Conversely, the calves inoculated with mutant in the cdt-III gene evolved in the same way as wild-type strain-inoculated calves with regard to clinical signs and macroscopic or microscopic lesions. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved. [less ▲]

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See detailAcquired aqueductal stenosis in preterm infants: an indication for neuroendoscopic third ventriculostomy
Scavarda, D; Bednarek, N; Litré, Claude Fabien ULg et al

in Child's Nervous System (2003), 19(10-11), 756-9

Abstract Object: The object of this study is to demonstrate the delayed occurrence of aqueductal stenosis in preterm infants who have suffered from intraventricular hemorrhage (IVH) and to try to explain ... [more ▼]

Abstract Object: The object of this study is to demonstrate the delayed occurrence of aqueductal stenosis in preterm infants who have suffered from intraventricular hemorrhage (IVH) and to try to explain the mechanisms of this stenosis. Method: From January 1996 to June 2002, 1,046 premature infants were admitted to our institution. Thirty-six neonates suffered from grade 3 or 4 intraventricular hemorrhage (Papile grading), of whom 16 died. Twenty patients survived and a ventriculoperitoneal shunt was inserted in 7 infants. Four patients underwent a neuroendoscopic third ventriculostomy. Follow-up was carried out, twice a month during the first 2 months and subsequently twice a year. Conclusion: In 2 children NTV was an effective treatment for hydrocephalus with an average follow-up of 29 months. The specific pattern concerning these patients is the long delay before obstructive hydrocephalus and the visualization of de novo obstruction with MRI. The biological explanation must be investigated. Keywords Premature newborn · Intraventricular hemorrhage · Hydrocephalus · Neuroendoscopy · Aqueductal stenosis · Acquired obstructive hydrocephalus · Transforming growth factor b1 [less ▲]

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See detailImagerie du vieillissement et de la démence
Collette, Fabienne ULg

Scientific conference (2003, November)

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See detailThe Inhibition of Cyclin-Dependent Kinases Induces Differentiation of Supernumerary Hair Cells and Deiters' Cells in the Developing Organ of Corti
Malgrange, Brigitte ULg; Knockaert, Marie; Belachew, Shibeshih ULg et al

in FASEB Journal (2003), 17(14), 2136-8

In the embryonic day 19 organs of Corti, we showed that roscovitine, a chemical inhibitor of cyclin-dependent kinases (CDKs), significantly increased the number of hair cells (HCs) and corresponding ... [more ▼]

In the embryonic day 19 organs of Corti, we showed that roscovitine, a chemical inhibitor of cyclin-dependent kinases (CDKs), significantly increased the number of hair cells (HCs) and corresponding supporting cells (SCs) by triggering differentiation of precursor cells without interacting with cell proliferation. The effect of roscovitine was mimicked by other CDK1, 2, 5, and 7 inhibitors but not by CDK4/6 and mitogen-activated protein kinase pathway antagonists. Immunohistochemical analysis indicated that roscovitine-specific intracellular targets, CDK1, 2, 5, and 7, were expressed in the organ of Corti and especially in Hensen's cells. Affinity chromatography studies showed a tight correlation between the protein levels of CDK1/2 and 5 and the rate of roscovitine-induced supernumerary cells in the organ of Corti. In addition, we demonstrated that basal CDK activity was higher and more roscovitine-sensitive at developmental stages that are selectively permissive for the emergence of supernumerary cells. These results suggest that CDKs are involved in the normal development of the organ of Corti and that, at least in E19 embryos, inhibition of CDKs is sufficient to trigger the differentiation of HCs and corresponding SCs, presumably from the Hensen's cell progenitors and/or from progenitors located in the greater epithelial ridge area. [less ▲]

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See detailIs parenteral nutrition guilty?
Varga, P.; Griffiths, R.; Chiolero, R. et al

in Intensive Care Medicine (2003), 29(11), 1861-1864

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See detailDo utility values and willingness to pay suitably reflect health outcome in hip and knee osteoarthritis? A comparative analysis with the WOMAC index
Ethgen, Olivier ULg; Tancredi, Annalisa ULg; Lejeune, Emmanuelle ULg et al

in Journal of Rheumatology (2003), 30(11), 2452-2459

Objective. To establish whether health utility (time trade-off, TTO) and willingness to pay (WTP) values reflect clinical health outcome as evaluated by the Western Ontario McMaster Universities ... [more ▼]

Objective. To establish whether health utility (time trade-off, TTO) and willingness to pay (WTP) values reflect clinical health outcome as evaluated by the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) in hip and knee osteoarthritis (OA). Methods. One hundred twenty-eight patients with OA attending a specialized arthritis clinic were interviewed about their socioeconomic characteristics and administered the TTO technique and the WOMAC. Their WTP for 2 hypothetical anti-osteoarthritic drugs was also investigated: the first drug was said to provide a significant improvement in WOMAC dimensions and the second a complete cure of the disease. WTP was elicited by both discrete-choice and bidding game methods. Results. Answer rates were 89.1% for TTO, 98.4% for discrete-choice WTP for both scenarios, and 89.8% and 85.2% for bidding game WTP in the relief and the cure scenario, respectively. The mean TTO utility value was 0.84 (standard deviation 0.20). In discrete-choice, those accepting the bid had higher monthly income (euro 1536.5 vs euro 1060. 1, p < 0.001, for the relief scenario and euro 1449.3 vs euro 1071.6, p < 0.001, for the cure scenario). With the bidding game format, WTP was positively correlated with income in both scenarios (r = 0.56, r = 0.55, p < 0.001). WTP measures differed equally between education and socioeconomic groups with those in favored groups consistently reporting higher WTP (Kruskal-Wallis tests statistics ranging from p < 0.01 to p < 0.001). Except for stiffness, WOMAC dimensions were correlated in the expected direction with TTO values (r = -0.27, p < 0.01 for pain and r = -0.36, r = -0.34, p < 0.001 for physical function and total score, respectively). Conclusion. Whereas they showed good feasibility, WTP measures poorly reflected clinical condition and were mainly related to economic status and ability to pay. TTO was correlated with the WOMAC dimensions and may be considered closer to clinical situations than WTP. However, concern arises regarding the homogeneity of the study sample in terms of clinical severity, which may have precluded the identification of a relationship between WTP and clinical status. [less ▲]

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See detailLe livre de l'ânesse de Balaam, de David Jones, Traduction, notes et introduction critique
Pagnoulle, Christine ULg; Pagnoulle, Christine ULg

Book published by Editions associatives Clapas (2003)

The poetic sequence called 'The book of Balaam's Ass' was only published after David Jones's death. It is indeed riddled with contradictions and inconsistencies, but of the kind that can hardly be ... [more ▼]

The poetic sequence called 'The book of Balaam's Ass' was only published after David Jones's death. It is indeed riddled with contradictions and inconsistencies, but of the kind that can hardly be overcome. In a nutshell it is about the loss of grace, both in the later stage of the Great War (from the Somme offensive onwards) and in a postwar world in which the author feels all sense of the holy has been erased. [less ▲]

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See detailAvances en diagnostico y tratamiento de acromegalia
Beckers, Albert ULg

Scientific conference (2003, November)

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See detailAnomalies métaboliques chez l'acromégale
Beckers, Albert ULg

Scientific conference (2003, November)

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See detailAcromegalia y prolactinomas en embaraza
Beckers, Albert ULg

Scientific conference (2003, November)

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See detailSolution structural study of BlaI: Implications for the repression of genes involved in beta-lactam antibiotic resistance
Van Melckebeke, H.; Vreuls, Christelle ULg; Gans, P. et al

in Journal of Molecular Biology (2003), 333(4), 711-720

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See detailLe politique, victime de la mondialisation ?
Geuens, Geoffrey ULg

Conference given outside the academic context (2003)

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