Polymer stretching in a turbulent flow through Brownian Dynamics

Conference (2003, November)

Chairman's introduction

in Osteoporosis International (2003, November), 14(Suppl. 7), 104

Evaluation of the relationship between IGF-I, IGF-BP3, BMD and age in men presenting at a multiple risk detection campaign

in Osteoporosis International (2003, November), 14(Suppl. 7), 90-91

The use of mycophenolate mofetil in liver transplant recipients

in Expert Opinion on Pharmacotherapy (2003), 4(11), 1949-1957

Mycophenolate mofetil is an important drug in the modern immunosuppressive arsenal. Mycophenolate mofetil is the semisynthetic morpholinoethyl ester of mycophenolate acid. Mycophenolate acid prevents T ... [more ▼]

Mycophenolate mofetil is an important drug in the modern immunosuppressive arsenal. Mycophenolate mofetil is the semisynthetic morpholinoethyl ester of mycophenolate acid. Mycophenolate acid prevents T and B cell proliferation by specifically inhibiting a purine pathway required for lymphocyte division. This paper extensively reviews the experience of mycophenolate mofetil use in liver transplant recipients. In randomised trials, mycophenolate mofetil decreased the rate of acute rejection after liver transplantation, without a significant increase of septic complications. However, so far, there are no data indicating that mycophenolate mofetil increases liver transplant patient or graft survivals. Mycophenolate mofetil is interesting because of its particular side effects profile, which is very different from the other immunosuppressants. The absence of mycophenolate mofetil nephrotoxicity is of specific interest in liver recipients with impairment of renal function. The monitoring of mycophenolate acid area under the concentration time curve might be interesting to limit side effects and provide better clinical efficacy but the exact role of mycophenolate acid monitoring in liver recipients has yet to be further evaluated in large series. [less ▲]

FEM study of metal sheets with a texture based, local description of the yield locus

Doctoral thesis (2003)

Bulletin de la Société Voltaire n°5

E-print/Working paper (2003)

Time-dependent risk of gastrointestinal complications induced by NSAIDS use: a consensus statement using meta-analytic approach

in Osteoporosis International (2003, November), 14(Suppl. 7), 9

Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses.

in Molecular & Cellular Biology (2003), 23(21), 7638-7647

The Fas ligand (FasL)/Fas pathway is crucial for homeostasis of the immune system and peripheral tolerance. Peripheral lymphocyte deletion involves FasL/Fas in at least two ways: coexpression of both Fas ... [more ▼]

The Fas ligand (FasL)/Fas pathway is crucial for homeostasis of the immune system and peripheral tolerance. Peripheral lymphocyte deletion involves FasL/Fas in at least two ways: coexpression of both Fas and its ligand on T cells, leading to activation-induced cell death, and expression of FasL by nonlymphoid cells, such as intestinal epithelial cells (IEC), that kill Fas-positive T cells. We demonstrate here that superantigen Staphylococcus enterotoxin B (SEB) induced a dramatic upregulation of FasL, TRAIL, and TNF mRNA expression and function in IEC from BALB/c and C57BL/6 mice. Using adoptive transfer in which CD4(+) T cells from OT-2 T-cell receptor transgenic mice were transferred into recipients, we observed an induction in IEC of FasL, TRAIL, and TNF mRNA after administration of antigen. Specific Egr-binding sites have been identified in the 5' promoter region of the FasL gene, and Egr-1, Egr-2, and Egr-3 mRNA in IEC from mice treated with SEB and from transgenic OT-2 mice after administration of antigen was upregulated. Overexpression of Egr-2 and Egr-3 induced endogenous ligand upregulation that was inhibited by overexpression of Egr-specific inhibitor Nab1. These results support a role for Egr family members in nonlymphoid expression of FasL, TRAIL, and TNF. [less ▲]

Identification et tautologie: L'identité chez Husserl et Wittgenstein

in Revue Philosophique de Louvain (2003), 101(4), 593-609

A question common to the sixth Logical Research of Husserl and to Wittgenstein's Tractatus is the question of the status of mathematical equations, and more broadly of judgements of identity. It is that ... [more ▼]

A question common to the sixth Logical Research of Husserl and to Wittgenstein's Tractatus is the question of the status of mathematical equations, and more broadly of judgements of identity. It is that of whether the mathematician expresses propositions, which as such bear a character of possible truth, or, on the contrary, simple rules of substitution useful for calculations. As formulated by Frege, this question can be summarized as follows: does mathematical knowledge exist? In reply to this question Husserl's position may be interpreted as being midway between Kant and Wittgenstein. [less ▲]

Quantification of tagitinin C in Tithonia diversifolia by reversed-phase high-performance liquid chromatography.

in Phytochemical Analysis [=PCA] (2003), 14(6), 378-80

A simple, rapid and reliable reversed-phase high-performance liquid chromatographic method for the determination of tagitinin C, an anti-plasmodial sesquiterpene lactone isolated from the aerial parts of ... [more ▼]

A simple, rapid and reliable reversed-phase high-performance liquid chromatographic method for the determination of tagitinin C, an anti-plasmodial sesquiterpene lactone isolated from the aerial parts of Tithonia diversifolia, has been developed. The assay has been used to quantify tagitinin C in various extracts of the aerial parts of T. diversifolia. [less ▲]