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See detailOptical and mechanical design of a straylight rejection baffle for CoRoT
Plesseria, Jean-Yves ULiege; Mazy, Emmanuel ULiege; Defise, Jean-Marc ULiege et al

in Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series (2003, November 01)

The COROT mission is part of the program "Petites Missions" of CNES (French space agency). It implies international cooperation between France, Belgium, Germany, Austria, Spain and the European Space ... [more ▼]

The COROT mission is part of the program "Petites Missions" of CNES (French space agency). It implies international cooperation between France, Belgium, Germany, Austria, Spain and the European Space Agency (ESA). COROT aims to perform astroseismology measurements and to detect exoplanets. Long duration observations of stars will be used to detect periodic variations with an afocal telescope followed by a dioptric objective and 4 CCDs. Due to the orbit of the spacecraft (low altitude polar orbit) and even if the observation are performed in a direction perpendicular to orbit plane, the measurements can be disturbed by the straylight reflected on the earth (albedo) that can generate periodic perturbation. CSL is in charge of the design and procurement, with the help of Belgian industries, of a baffle and its protective cover that will be mounted on top of the afocal entrance telescope. The requirements are very stringent from the optical point of view as well as from the mechanical point of view. The rejection of the baffle must be of the order of 10[SUP]13[/SUP] for field angles above 20 degrees while the allocated mass is 19 kilograms. [less ▲]

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See detailOverexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: Pathophysiological consequences
Tsatsaris, V.; Goffin, Frédéric ULiege; Munaut, Carine ULiege et al

in Journal of Clinical Endocrinology and Metabolism (2003), 88(11), 5555-5563

Several growth factors such as vascular endothelial growth factor (VEGF)-A and placental growth factor (PlGF) are involved in the placental vascular development. We investigated whether dysregulation in ... [more ▼]

Several growth factors such as vascular endothelial growth factor (VEGF)-A and placental growth factor (PlGF) are involved in the placental vascular development. We investigated whether dysregulation in the VEGF family may explain the defective uteroplacental vascularization characterizing preeclampsia. We compared pregnancies complicated by early onset severe preeclampsia or intrauterine growth retardation to normal pregnancies. Maternal plasma, placentas, and placental bed biopsies were collected. The mRNA levels of VEGF-A, PlGF, and their receptors were quantified in placentas and placental beds. Levels of VEGF-A, PlGF, and soluble VEGF receptor (VEGFR) were assessed in maternal plasma. In compromised pregnancies, elevated levels of VEGF-A and VEGFR-1 mRNAs may reflect the hypoxic status of the placenta. On contrast, the membrane-bound VEGFR-1 was decreased in the placental bed of preeclamptic patients. Preeclampsia was associated with low levels of circulating PlGF and increased levels of total VEGF-A and soluble VEGFR-1. Free VEGF-A was undetectable in maternal blood. Immunohistochemical studies revealed that VEGF-A and PlGF were localized in trophoblastic cells. Altogether, our results suggest two different pathophysiological mechanisms associated with preeclampsia. The first one is related to an overproduction of competitive soluble VEGFR-1 that may lead to suppression of VEGF-A and PlGF effects. The second one is the down-regulation of its membrane bound form (VEGFR-1) in the placental bed, which may result in the defective uteroplacental development. [less ▲]

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See detailJupiter's main auroral oval observed with HST-STIS
Grodent, Denis ULiege; Clarke, J. T.; Kim, J. et al

in Journal of Geophysical Research. Space Physics (2003), 108(A11),

An extended series of FUV images obtained on 7 days during winter 2000-2001, with fixed pointing, yielded highly accurate tracking of emisson features as Jupiter rotated. They provided newly detailed ... [more ▼]

An extended series of FUV images obtained on 7 days during winter 2000-2001, with fixed pointing, yielded highly accurate tracking of emisson features as Jupiter rotated. They provided newly detailed measurements of the degree of corotation of auroral emissions and their variations with changing central meridian longitude. This 2-month data set provides a statistical average location of the auroral emission and leads to the definition of new "reference ovals.'' The overall auroral morphology pattern is shown to be fixed in System-III longitude and unchanged over a 5-year period. When arranged in central meridian longitude ranges, the images show a significant contraction of the northern main oval as the central meridian longitude increases from 115 to 255degrees. The main auroral oval brightness is globally very stable in comparison with its terrestrial counterpart. It is shown to vary with magnetic local time, increasing from noon to dusk and then decreasing again in the magnetic evening. Hectometric emissions observed simultaneously with Galileo and Cassini reveal interplanetary shocks propagating outward from the Sun which may be related to the contraction of the main auroral oval observed in the HST images taken on 14 December 2000. In addition, we find that a brightening and a significant contraction of the main oval observed on 13 January 2001 corresponded to a time of increased solar wind dynamic pressure. [less ▲]

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See detailPharmacodynamics of follicle stimulating hormone (FSH) in postmenopausal women during pulsed estrogen therapy: Evidence that FSH release and synthesis are controlled by distinct pathways
Christin-Maitre, S.; Laveille, C.; Collette, Julien ULiege et al

in Journal of Clinical Endocrinology and Metabolism (2003), 88(11), 5405-5413

17beta-Estradiol (E2) exerts negative feedback effects at the hypothalamo-pituitary level on serum FSH. This study investigated the effects of repeated daily administration of intranasal E2 (S21400) on ... [more ▼]

17beta-Estradiol (E2) exerts negative feedback effects at the hypothalamo-pituitary level on serum FSH. This study investigated the effects of repeated daily administration of intranasal E2 (S21400) on the pharmacokinetics (PK) of E2 and estrone (E1) and the pharmacodynamics (PD) of FSH and assessed the PK/PD relationship between E2 and FSH using population model-dependent analysis. Postmenopausal volunteers (n = 24) received according to a balanced cross-over design, two 28-d treatments separated by a 2-month wash-out period: 300 mug E2, either alone or combined with oral dydrogesterone (20 mg/d) during the last 14 d of one of the treatments. Absorption of E2 was rapid, with maximal plasma concentrations at 10-30 min, returning to postmenopausal levels within 12 h. Over the 24-h period, FSH levels showed a U curve, with a minimum around 8 h after E2 administration. Moreover, over the treatment period, FSH basal values decreased by 17% between d 1 and 14 and an additional 5% between d 14 and 28. A PK/PD model described these short- and mid-term effects, possibly reflecting separate regulation mechanisms by E2 on FSH release and biosynthesis, respectively. The administration of progestin had no influence on E1, E2, and FSH model parameters. This study suggests that daily transient tissue exposure to E2 after pulsed estrogen therapy elicits short- and mid-term effects on the gonadotropin axis. [less ▲]

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See detailEvolution of the polarization of the optical afterglow of the γ-ray burst GRB030329
Greiner, Jochen; Klose, Sylvio; Reinsch, Klaus et al

in Nature (2003), 426

The association of a supernova with GRB030329 strongly supports the `collapsar' model of γ-ray bursts, where a relativistic jet forms after the progenitor star collapses. Such jets cannot be spatially ... [more ▼]

The association of a supernova with GRB030329 strongly supports the `collapsar' model of γ-ray bursts, where a relativistic jet forms after the progenitor star collapses. Such jets cannot be spatially resolved because γ-ray bursts lie at cosmological distances; their existence is instead inferred from `breaks' in the light curves of the afterglows, and from the theoretical desire to reduce the estimated total energy of the burst by proposing that most of it comes out in narrow beams. Temporal evolution of the polarization of the afterglows may provide independent evidence for the jet structure of the relativistic outflow. Small-level polarization (~1-3 per cent) has been reported for a few bursts, but its temporal evolution has yet to be established. Here we report polarimetric observations of the afterglow of GRB030329. We establish the polarization light curve, detect sustained polarization at the per cent level, and find significant variability. The data imply that the afterglow magnetic field has a small coherence length and is mostly random, probably generated by turbulence, in contrast with the picture arising from the high polarization detected in the prompt γ-rays from GRB021206 (ref. 18). [less ▲]

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See detailGeneva photometry of HD 129929 (Aerts+, 2004)
Aerts, C.; Waelkens, C.; Daszynska-Daszkiewicz, J. et al

in SIMBAD (2003), 341

We have gathered and analysed a timeseries of 1493 high-quality multicolour Geneva photometric data of the B3V {beta} Cep star Hd 129929. The dataset has a time base of 21.2 years. The occurrence of a ... [more ▼]

We have gathered and analysed a timeseries of 1493 high-quality multicolour Geneva photometric data of the B3V {beta} Cep star Hd 129929. The dataset has a time base of 21.2 years. The occurrence of a beating phenomenon is evident from the data. We find evidence for the presence of at least six frequencies, among which we see components of two frequency multiplets with an average spacing of ~0.0121c/d which points towards very slow rotation. This result is in agreement with new spectroscopic data of the star and also with previously taken UV spectra. We provide the amplitudes of the six frequencies in all seven photometric filters. The metal content of the star is Z=0.018+/-0.004. All these observational results will be used to perform detailed seismic modelling of this massive star in a subsequent paper. (1 data file). [less ▲]

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See detailRemote sensing of the proton aurora characteristics from IMAGE-FUV
Bisikalo, D. V.; Shematovich, V. I.; Gérard, Jean-Claude ULiege et al

in Annales Geophysicae (2003), 21

The combination of simultaneous global images of the north polar region obtained with the IMAGE-FUV imaging system makes it possible to globally map the properties of the electron and proton auroral ... [more ▼]

The combination of simultaneous global images of the north polar region obtained with the IMAGE-FUV imaging system makes it possible to globally map the properties of the electron and proton auroral precipitation. The SI12 imager, which observes the Doppler-shifted Lyman-a [less ▲]

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See detailDioxin/polychlorinated biphenyl body burden, diabetes and endometriosis: findings in a population-based study in Belgium
Fierens, S.; Mairesse, H.; Heilier, J. F. et al

in Biomarkers : Biochemical Indicators of Exposure, Response, & Susceptibility to Chemicals (2003), 8(6), 529-534

Dioxins and polychlorinated biphenyls (PCBs) are persistent organic pollutants widely distributed in the food chain, which is the main source of human exposure. Their effects on human health at background ... [more ▼]

Dioxins and polychlorinated biphenyls (PCBs) are persistent organic pollutants widely distributed in the food chain, which is the main source of human exposure. Their effects on human health at background exposure levels are still poorly understood. Recent epidemiological evidence suggests a possible association between these pollutants and diabetes. We report here the results of a population-based study in Belgium on 257 (142 women and 115 men) environmentally exposed subjects, including 10 cases of endometriosis and nine cases of diabetes. Seventeen 2,3,7,8-polychlorinated dibenzodioxins/dibenzofurans (PCDD/Fs or dioxins), four coplanar PCBs (International Union of Pure and Applied Chemistry [IUPAC] nos 77, 81, 126 and 169) and 12 PCB markers ( IUPAC nos 3, 8, 28, 52, 101, 118, 138, 153, 180, 194, 206 and 209) were quantified in serum fat from fasting blood samples in order to estimate the body burden of these pollutants. Whilst no difference was found between women with endometriosis and their controls, diabetic patients had significantly increased serum levels of dioxins, coplanar PCBs and the 12 PCB markers. After adjustment for age and other covariates, serum total toxic equivalent activity (sum of PCDD/Fs and coplanar PCBs) and 12 PCB marker concentrations in diabetics were 62% (p=0.0005) and 39% (p=0.0067) higher, respectively, than in controls. The risk of diabetes was significantly increased in subjects in the top decile for adjusted concentrations of dioxins (odds ratio 5.1, 95% confidence interval [CI] 1.18-21.7), coplanar PCBs (odds ratio 13.3, 95% CI 3.31-53.2) or 12 PCB markers (odds ratio 7.6, 95% CI 1.58-36.3). These findings warrant further studies to assess the significance of the associations between diabetes and environmental exposure to polychlorinated pollutants. [less ▲]

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See detailEvaluation of an osteoporosis screening campaign in the general population: does misclassification by screening test impact on the perception of the campaign?
Richy, Florent; Pire, G.; Maassen, P. et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 68

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See detailUncoupling of bone formation and resorption with a novel oral formulation of salmon calcitonin in postmenopausal women
Tanko, L. B.; Bagger, Y. Z.; Devogelaer, Jean-Pierre et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 4

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See detailFive-year follow-up patients issued from a previous 3-year randomised, controlled trial of glucosamine sulfate in knee osteoarthritis
Bruyère, Olivier ULiege; Compère, S.; Gathy, C. et al

in Osteoporosis International (2003, November), 14(Suppl 7), 9

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See detailEvaluation of a campaign for osteoporosis screening in the general population: what is the follow-up given by general practitioners to a positive screening result?
Richy, Florent; Pire, G.; Maassen, P. et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 67

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See detailEvaluation of prevalence of osteoporosis and osteopenia in men presenting at multiple risk detection campaign
Hanssens, L.; De Ceulaer, F.; Tancredi, Annalisa ULiege et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 90

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See detailEvaluation of the osteoporosis self-assessment tool (OST) as a screening test for osteoporosis and osteopenia in men
De Ceulaer, F.; Hanssens, L.; Tancredi, Annalisa ULiege et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 93

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See detailUse of healthcare resources related to gastrointestinal toxicity of NSAIDS
Rabenda, Véronique ULiege; Belaiche, Jacques ULiege; Raeman, F. et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 14

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See detailControlled whole body vibration to decrease fall risk and improve health related quality of life in elderly patients
Bruyère, Olivier ULiege; Wuidart, M. A.; di Palma, E. et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 63

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See detailRelief in mild-to-moderate pain is not a confounder in joint space narrowing assessment of full extension knee radiographs in recent osteoarthritis structure modifying drug trials
Pavelka, K.; Bruyère, Olivier ULiege; Rovati, Lucio C et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 62-63

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See detailGlucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two large, randomised, placebo-controlled, double-blind, 3-year studies
Bruyère, Olivier ULiege; Pavelka, K.; Rovati, Lucio C et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 62

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See detailBone mineral density and vertebral fractures in women who have discontinued hormone replacement therapy: a retrospective population-based study
Richy, Florent; Gourlay, M.; Neuprez, Audrey ULiege et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 67

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