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See detailPharmacodynamics of follicle stimulating hormone (FSH) in postmenopausal women during pulsed estrogen therapy: Evidence that FSH release and synthesis are controlled by distinct pathways
Christin-Maitre, S.; Laveille, C.; Collette, Julien ULg et al

in Journal of Clinical Endocrinology and Metabolism (2003), 88(11), 5405-5413

17beta-Estradiol (E2) exerts negative feedback effects at the hypothalamo-pituitary level on serum FSH. This study investigated the effects of repeated daily administration of intranasal E2 (S21400) on ... [more ▼]

17beta-Estradiol (E2) exerts negative feedback effects at the hypothalamo-pituitary level on serum FSH. This study investigated the effects of repeated daily administration of intranasal E2 (S21400) on the pharmacokinetics (PK) of E2 and estrone (E1) and the pharmacodynamics (PD) of FSH and assessed the PK/PD relationship between E2 and FSH using population model-dependent analysis. Postmenopausal volunteers (n = 24) received according to a balanced cross-over design, two 28-d treatments separated by a 2-month wash-out period: 300 mug E2, either alone or combined with oral dydrogesterone (20 mg/d) during the last 14 d of one of the treatments. Absorption of E2 was rapid, with maximal plasma concentrations at 10-30 min, returning to postmenopausal levels within 12 h. Over the 24-h period, FSH levels showed a U curve, with a minimum around 8 h after E2 administration. Moreover, over the treatment period, FSH basal values decreased by 17% between d 1 and 14 and an additional 5% between d 14 and 28. A PK/PD model described these short- and mid-term effects, possibly reflecting separate regulation mechanisms by E2 on FSH release and biosynthesis, respectively. The administration of progestin had no influence on E1, E2, and FSH model parameters. This study suggests that daily transient tissue exposure to E2 after pulsed estrogen therapy elicits short- and mid-term effects on the gonadotropin axis. [less ▲]

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See detailEvolution of the polarization of the optical afterglow of the γ-ray burst GRB030329
Greiner, Jochen; Klose, Sylvio; Reinsch, Klaus et al

in Nature (2003), 426

The association of a supernova with GRB030329 strongly supports the `collapsar' model of γ-ray bursts, where a relativistic jet forms after the progenitor star collapses. Such jets cannot be spatially ... [more ▼]

The association of a supernova with GRB030329 strongly supports the `collapsar' model of γ-ray bursts, where a relativistic jet forms after the progenitor star collapses. Such jets cannot be spatially resolved because γ-ray bursts lie at cosmological distances; their existence is instead inferred from `breaks' in the light curves of the afterglows, and from the theoretical desire to reduce the estimated total energy of the burst by proposing that most of it comes out in narrow beams. Temporal evolution of the polarization of the afterglows may provide independent evidence for the jet structure of the relativistic outflow. Small-level polarization (~1-3 per cent) has been reported for a few bursts, but its temporal evolution has yet to be established. Here we report polarimetric observations of the afterglow of GRB030329. We establish the polarization light curve, detect sustained polarization at the per cent level, and find significant variability. The data imply that the afterglow magnetic field has a small coherence length and is mostly random, probably generated by turbulence, in contrast with the picture arising from the high polarization detected in the prompt γ-rays from GRB021206 (ref. 18). [less ▲]

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See detailGeneva photometry of HD 129929 (Aerts+, 2004)
Aerts, C.; Waelkens, C.; Daszynska-Daszkiewicz, J. et al

in SIMBAD (2003), 341

We have gathered and analysed a timeseries of 1493 high-quality multicolour Geneva photometric data of the B3V {beta} Cep star Hd 129929. The dataset has a time base of 21.2 years. The occurrence of a ... [more ▼]

We have gathered and analysed a timeseries of 1493 high-quality multicolour Geneva photometric data of the B3V {beta} Cep star Hd 129929. The dataset has a time base of 21.2 years. The occurrence of a beating phenomenon is evident from the data. We find evidence for the presence of at least six frequencies, among which we see components of two frequency multiplets with an average spacing of ~0.0121c/d which points towards very slow rotation. This result is in agreement with new spectroscopic data of the star and also with previously taken UV spectra. We provide the amplitudes of the six frequencies in all seven photometric filters. The metal content of the star is Z=0.018+/-0.004. All these observational results will be used to perform detailed seismic modelling of this massive star in a subsequent paper. (1 data file). [less ▲]

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See detailOptical and mechanical design of a straylight rejection baffle for CoRoT
Plesseria, Jean-Yves ULg; Mazy, Emmanuel ULg; Defise, Jean-Marc ULg et al

in Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series (2003, November 01)

The COROT mission is part of the program "Petites Missions" of CNES (French space agency). It implies international cooperation between France, Belgium, Germany, Austria, Spain and the European Space ... [more ▼]

The COROT mission is part of the program "Petites Missions" of CNES (French space agency). It implies international cooperation between France, Belgium, Germany, Austria, Spain and the European Space Agency (ESA). COROT aims to perform astroseismology measurements and to detect exoplanets. Long duration observations of stars will be used to detect periodic variations with an afocal telescope followed by a dioptric objective and 4 CCDs. Due to the orbit of the spacecraft (low altitude polar orbit) and even if the observation are performed in a direction perpendicular to orbit plane, the measurements can be disturbed by the straylight reflected on the earth (albedo) that can generate periodic perturbation. CSL is in charge of the design and procurement, with the help of Belgian industries, of a baffle and its protective cover that will be mounted on top of the afocal entrance telescope. The requirements are very stringent from the optical point of view as well as from the mechanical point of view. The rejection of the baffle must be of the order of 10[SUP]13[/SUP] for field angles above 20 degrees while the allocated mass is 19 kilograms. [less ▲]

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See detailOverexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: Pathophysiological consequences
Tsatsaris, V.; Goffin, Frédéric ULg; Munaut, Carine ULg et al

in Journal of Clinical Endocrinology and Metabolism (2003), 88(11), 5555-5563

Several growth factors such as vascular endothelial growth factor (VEGF)-A and placental growth factor (PlGF) are involved in the placental vascular development. We investigated whether dysregulation in ... [more ▼]

Several growth factors such as vascular endothelial growth factor (VEGF)-A and placental growth factor (PlGF) are involved in the placental vascular development. We investigated whether dysregulation in the VEGF family may explain the defective uteroplacental vascularization characterizing preeclampsia. We compared pregnancies complicated by early onset severe preeclampsia or intrauterine growth retardation to normal pregnancies. Maternal plasma, placentas, and placental bed biopsies were collected. The mRNA levels of VEGF-A, PlGF, and their receptors were quantified in placentas and placental beds. Levels of VEGF-A, PlGF, and soluble VEGF receptor (VEGFR) were assessed in maternal plasma. In compromised pregnancies, elevated levels of VEGF-A and VEGFR-1 mRNAs may reflect the hypoxic status of the placenta. On contrast, the membrane-bound VEGFR-1 was decreased in the placental bed of preeclamptic patients. Preeclampsia was associated with low levels of circulating PlGF and increased levels of total VEGF-A and soluble VEGFR-1. Free VEGF-A was undetectable in maternal blood. Immunohistochemical studies revealed that VEGF-A and PlGF were localized in trophoblastic cells. Altogether, our results suggest two different pathophysiological mechanisms associated with preeclampsia. The first one is related to an overproduction of competitive soluble VEGFR-1 that may lead to suppression of VEGF-A and PlGF effects. The second one is the down-regulation of its membrane bound form (VEGFR-1) in the placental bed, which may result in the defective uteroplacental development. [less ▲]

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See detailFEM study of metal sheets with a texture based, local description of the yield locus
Duchene, Laurent ULg

Doctoral thesis (2003)

Résumé de l’ouvrage La thèse déposée par L. Duchêne comporte cinq chapitres dont une introduction et des conclusions et perspectives et totalise 183 pages. La bibliographie compte 94 références. L’ouvrage ... [more ▼]

Résumé de l’ouvrage La thèse déposée par L. Duchêne comporte cinq chapitres dont une introduction et des conclusions et perspectives et totalise 183 pages. La bibliographie compte 94 références. L’ouvrage a pour objet la modélisation du comportement mécanique des tôles métalliques (principalement des tôles d’acier obtenues par laminage) lors des processus de mise à forme. L’anisotropie de la tôle découle de la mesure de la texture du matériau. Les processus de mise à forme étudiés sont principalement l’emboutissage des tôles. Le mémoire propose le développement de deux méthodes locales d’interpolation de la surface de plasticité. Ensuite, ces modèles sont implémentés dans le code éléments finis LAGAMINE, puis validés sur quelques exemples académiques et finalement des applications industrielles sont examinées. Analyse du contenu Le premier chapitre introduit le sujet, définit le cadre dans lequel l’auteur situe sa démarche et présente les originalités du travail. Le deuxième chapitre est consacré à la description du comportement microscopique des métaux et des méthodes de transition micro-macro. Le comportement d’un monocristal ou plutôt le comportement d’un cristal à l’intérieur d’un polycristal est examiné. Les modèles microscopiques de Taylor et de Bishop-Hill constituant une approche primal-dual pour ce problème sont décrits. Le comportement macroscopique du polycristal est obtenu à partir du comportement microscopique via la transition micro-macro sur base de la texture du matériau. Cette texture est généralement caractérisée par son ODF (Orientation Distribution Function). Cependant, le modèle de transition micro-macro utilisé, basé sur les hypothèses de Taylor, nécessite une description de la texture par un ensemble d’orientations cristallines représentatif de la texture du matériau. Différentes méthodes d’extraction de l’ensemble de cristaux représentatif sont décrites. Le nombre de cristaux inclus dans l’ensemble représentatif est un paramètre important et est discuté. Le comportement élastique et plastique du polycristal sont décrits. Outre le modèle de transition micro-macro basé sur les hypothèses de Taylor, d’autres modèles plus récents et plus coûteux en temps de calcul sont décrits. Le deuxième chapitre introduit également l’écrouissage du polycristal. Le troisième chapitre présente les étapes successives du développement de l’approche locale de la surface de plasticité. Etant donné que la surface de plasticité est définie dans l’espace à 5 dimensions des contraintes déviatoriques, des notions de géométrie dans un espace à n dimensions sont présentées. Différentes propriétés des domaines dans lesquels la surface de plasticité est localement définie sont décrites ; ainsi que la méthode de construction des domaines et le lien entre domaines voisins. Deux méthodes d’interpolation à partir de points calculés via le modèle de Taylor de la surface de plasticité à l’intérieur des domaines ont été développées et sont présentées. La méthode de hyperplans définit localement la surface de plasticité au moyen d’hyperplans (des plans dans l’espace à 5 dimensions des contraintes déviatoriques). La méthode d’interpolation directe contraintes-déformations permet une représentation plus précise et plus continue entre domaines voisins de la surface de plasticité. Etant donné son importance cruciale pour la convergence des simulations numériques utilisant la méthode des éléments finis, la normale à la surface de plasticité est soigneusement examinée pour les deux méthodes locales d’interpolation. Certains problèmes particuliers rencontrés lors du développement et liés à l’approche locale de la surface de plasticité sont présentés pour les deux méthodes d’interpolation. Quelques points particuliers liés à l’implémentation de ces méthodes dans le code éléments finis LAGAMINE sont décrits. Le principal intérêt de l’approche locale de la surface de plasticité est son efficacité lors du calcul de l’évolution de texture au cours des déformations plastiques. Un paragraphe est dès lors consacré aux détails de calcul des rotations des orientations cristallines et à l’implémentation de l’évolution de texture dans le code éléments finis. Le chapitre 3 se termine par un paragraphe qui analyse la précision, la robustesse et le gain en temps de calcul (par rapport à l’utilisation directe du modèle de Taylor) de l’approche locale de la surface de plasticité. Le quatrième chapitre présente les validations de l’approche locale de la surface de plasticité. Trois validations académiques sont tout d’abord effectuées : prédiction de l’évolution de texture lors du laminage ; prédiction de l’effet Swift en cours de torsion d’un tube ou d’un cylindre et comparaison du comportement en torsion et compression des métaux cubiques faces centrées et cubiques centrés isotropes. La première validation complexe est l’emboutissage de godets circulaires à fond plat. Les résultats des simulations (distribution des déformations plastiques, évolution de la force poinçon en fonction du temps, prédiction des oreilles d’emboutissage et prédiction de la texture finale) sont comparés aux valeurs expérimentales. La géométrie du processus d’emboutissage, la mesure des valeurs expérimentales et les paramètres numériques utilisés pour les simulations sont largement détaillés. L’influence de certains paramètres numériques sur les résultats des simulations est de plus analysée. Une seconde simulation d’emboutissage avec une autre géométrie et un matériau plus anisotrope est également étudiée. Les oreilles d’emboutissage sont particulièrement analysées ; le retour élastique dû à un retrait des outils est examiné. Le mémoire se termine par un cinquième chapitre qui présente des perspectives et des conclusions permettant à l’auteur de synthétiser les apports de sa thèse et d’indiquer quelles directions de recherches lui paraissent devoir être explorées dans le futur. [less ▲]

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See detailEvaluation of an osteoporosis screening campaign in the general population: does misclassification by screening test impact on the perception of the campaign?
Richy, Florent; Pire, G.; Maassen, P. et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 68

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See detailIdentification et tautologie: L'identité chez Husserl et Wittgenstein
Seron, Denis ULg

in Revue Philosophique de Louvain (2003), 101(4), 593-609

A question common to the sixth Logical Research of Husserl and to Wittgenstein's Tractatus is the question of the status of mathematical equations, and more broadly of judgements of identity. It is that ... [more ▼]

A question common to the sixth Logical Research of Husserl and to Wittgenstein's Tractatus is the question of the status of mathematical equations, and more broadly of judgements of identity. It is that of whether the mathematician expresses propositions, which as such bear a character of possible truth, or, on the contrary, simple rules of substitution useful for calculations. As formulated by Frege, this question can be summarized as follows: does mathematical knowledge exist? In reply to this question Husserl's position may be interpreted as being midway between Kant and Wittgenstein. [less ▲]

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See detailUncoupling of bone formation and resorption with a novel oral formulation of salmon calcitonin in postmenopausal women
Tanko, L. B.; Bagger, Y. Z.; Devogelaer, Jean-Pierre et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 4

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See detailModélisation d'une semelle filante de fondation: influence de la règle d'écoulement, de l'angle de Lode et du maillage.
El Hammoumi, O.; Charlier, Robert ULg

in Int. Conf. FondSup - Fondations Superficielles (2003, November)

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See detailEvaluation of a campaign for osteoporosis screening in the general population: what is the follow-up given by general practitioners to a positive screening result?
Richy, Florent; Pire, G.; Maassen, P. et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 67

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See detailStimulation magnétique et reorganisation motrice apres un AVC
DELVAUX, Valérie ULg

Article for general public (2003)

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See detailFive-year follow-up patients issued from a previous 3-year randomised, controlled trial of glucosamine sulfate in knee osteoarthritis
Bruyère, Olivier ULg; Compère, S.; Gathy, C. et al

in Osteoporosis International (2003, November), 14(Suppl 7), 9

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See detailEvaluation of prevalence of osteoporosis and osteopenia in men presenting at multiple risk detection campaign
Hanssens, L.; De Ceulaer, F.; Tancredi, Annalisa ULg et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 90

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See detailEvaluation of the osteoporosis self-assessment tool (OST) as a screening test for osteoporosis and osteopenia in men
De Ceulaer, F.; Hanssens, L.; Tancredi, Annalisa ULg et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 93

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See detailUse of healthcare resources related to gastrointestinal toxicity of NSAIDS
Rabenda, Véronique ULg; Belaiche, Jacques ULg; Raeman, F. et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 14

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See detailControlled whole body vibration to decrease fall risk and improve health related quality of life in elderly patients
Bruyère, Olivier ULg; Wuidart, M. A.; di Palma, E. et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 63

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See detailRelief in mild-to-moderate pain is not a confounder in joint space narrowing assessment of full extension knee radiographs in recent osteoarthritis structure modifying drug trials
Pavelka, K.; Bruyère, Olivier ULg; Rovati, Lucio C et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 62-63

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See detailBone mineral density and vertebral fractures in women who have discontinued hormone replacement therapy: a retrospective population-based study
Richy, Florent; Gourlay, M.; Neuprez, Audrey ULg et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 67

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See detailTime-dependent assessment of the gastrointestinal risk induced by low-dose aspirin intake: a meta-analysis
Richy, Florent; Bruyère, Olivier ULg; Ethgen, Olivier ULg et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 95

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