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See detailPharmacological evaluation of BM-573, a dual thromboxane A2 receptor antagonist and thromboxane synthase inhibitor, as potential anti-metastatic agent
De Leval, X.; Dassesse, T.; Benoît, V. et al

Poster (2003, December)

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See detailSite-directed mutagenesis of conserved inverted repeat sequences in the xylanase C promoter region from Streptomyces sp EC3
Giannotta, F.; Georis, J.; Rigali, Sébastien ULg et al

in Molecular Genetics & Genomics (2003), 270(4), 337-346

Streptomyces sp. EC3, a strain which was originally isolated from cattle manure compost, was shown to possess a strong xylanolytic activity. One of the genes responsible for this activity, xlnC, encodes a ... [more ▼]

Streptomyces sp. EC3, a strain which was originally isolated from cattle manure compost, was shown to possess a strong xylanolytic activity. One of the genes responsible for this activity, xlnC, encodes a secreted xylanase. In the native strain, as in the heterologous host S. lividans, expression of xlnC was detectable in the presence of xylan but not in the presence of glucose. Induction by xylan was shown to take place at the transcriptional level. The transcriptional start site of xlnC was mapped and likely -35 (5'-TTGACA-3') and -10 (5'-GAGAAC-3') motifs were identified. In order to localise putative conserved regulatory sequences, the promoter regions of xylanase-encoding genes from various Streptomyces species were aligned. This alignment revealed the existence of three sets of quite well conserved palindromic AT rich sequences called boxes 1, 2 and 3. Box 3 (5'-CGAAA N TTTCG-3') is the farthest away from the promoter region (150-200 bp). A shorter version of this palindrome (5'-GAAA NN TTTC-3') or (5'-CGAAA-3') constitutes box 1, which is located just upstream of the putative -35 promoter sequence. Box 2, located 5-7 bp upstream of box 1, comprises a shorter palindrome than box 3, with inverted polarity [5'-(G/C)TTTC (N) GAAA(G/C)-3']. The putative regulatory role of the conserved inverted repeats in boxes 2 and 3 in the promoter region of the xlnC gene from Streptomyces sp. EC3, was assessed. These boxes were modified by site-directed mutagenesis, and the mutant promoter regions, as well as the wild-type promoter region, were separately fused to a beta-lactamase reporter gene. Analysis of the expression patterns of these fusions in cultures grown in the presence of glucose, xylan or both carbon sources demonstrated that these motifs were cis -acting negative regulatory elements, each playing a specific role in the regulation of xlnC expression. Box 3 was shown to be critical for the establishment of repression of xlnC expression by glucose, whereas box 2 was shown to play an important role in the induction of xlnC expression by xylan. [less ▲]

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See detailAromatase (estrogen synthase) activity in the dorsal horn of the spinal cord: Functional implications
Evrard, H. C.; Balthazart, Jacques ULg

in Annals of the New York Academy of Sciences (2003), 1007

The presence of aromatase (estrogen synthase) in neurons in the dorsal horn of the spinal cord in Japanese quail suggests that estrogens produced locally from androgens could control spinal sensory ... [more ▼]

The presence of aromatase (estrogen synthase) in neurons in the dorsal horn of the spinal cord in Japanese quail suggests that estrogens produced locally from androgens could control spinal sensory processes including nociception. We used the hot water nociceptive test (54 degreesC) to appraise the longterm effect of an inhibition of aromatization on the foot withdrawal latency in male quail. Four weeks after the ablation of their main source of testosterone (testes), castrated males displayed a significantly higher foot withdrawal latency than gonadally intact males. A prolonged treatment with subcutaneous capsules filled with testosterone or 17 beta-estradiol restored the baseline latency within 2 weeks. The effect of testosterone in castrated quail was almost completely blocked by systemic injections of Vorozole((TM)), a nonsteroidal aromatase inhibitor or tamoxifen, an estrogen receptor antagonist (one injection per day for 10 days). Taken together, these data demonstrate for the first time to our knowledge an effect of estrogens formed by aromatization of androgens on nociception. Because aromatase-immunoreactive neurons and aromatase activity are present in the dorsal horns of the spinal cord, this control of pain thresholds is presumably mediated, at least in part, by estrogens produced at the spinal level that act locally via slow, presumably genomic, mechanisms mediated by the activation of spinal nuclear estrogen receptors. [less ▲]

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See detailBM-613, a new thromboxane A2 antagonist, is characterized by a preferential activity on platelet thromboxane A2 receptors
Hanson, Julien ULg; Rolin, S.; De Leval, X. et al

Poster (2003, December)

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See detailPerformance of the VERSANT (R) HIV-1 Resistance Assays (LiPA) for detecting drug resistance in therapy-naive patients infected with different HIV-1 subtypes
Derdelinckx, Inge; Van Laethem, Kristel; Maes, Baert et al

in FEMS Immunology & Medical Microbiology (2003), 39(2), 119-124

In this study we evaluated the performance of the VERSANT((R)) HIV-1 Resistance Assays (LiPA) in detecting drug resistance in therapy-naive HIV-infected patients diagnosed in Belgium in 2000. We compared ... [more ▼]

In this study we evaluated the performance of the VERSANT((R)) HIV-1 Resistance Assays (LiPA) in detecting drug resistance in therapy-naive HIV-infected patients diagnosed in Belgium in 2000. We compared the results with population sequencing and found concordance to be in line with previous studies in treatment-experienced patients (86.87% for reverse transcriptase (RT); 92.77% for protease (PRO)). Discordance was mainly due to indeterminate reactions on LiPA (8.45% for RT; 6.85% for PRO) and minor discordances (4.13% for RT; 0.25% for PRO). Major discordances were rare (0.46% for RT; 0.12% for PRO). Indeterminate reactions were significantly associated with strains belonging to non-B subtypes. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier B.V.. All rights reserved. [less ▲]

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See detailStable uudd \bar s pentaquarks in the constituent quark model
Stancu, Floarea ULg; Riska, D. O.

in Physics Letters B (2003), 575(3-4), 242-248

The stability of strange pentaquarks uudd (s) over bar is studied in a constituent quark model based on a flavor-spin hyperfine interaction between quarks. With this interaction model, which schematically ... [more ▼]

The stability of strange pentaquarks uudd (s) over bar is studied in a constituent quark model based on a flavor-spin hyperfine interaction between quarks. With this interaction model, which schematically represents the Goldstone boson exchange interaction between constituent quarks, the lowest lying strange pentaquark is a p-shell state with positive parity. The flavor-spin interaction lowers the energy of the lowest p-shell state below that of the lowest s-shell state, which has negative parity because of the negative parity of the strange antiquark. It is found that the strange pentaquark can be stable against strong decay provided that the strange antiquark interacts by a fairly strong spin-spin interaction with u and d quarks. This interaction has a form that corresponds to, eta meson exchange. Its strength may be inferred from the pi(0) decay width of D*(s) mesons. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailGestion de l’étalement résidentiel. Comparaisons européennes
Halleux, Jean-Marie ULg

Conference given outside the academic context (2003)

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See detailHypertension artérielle et néphropathie diabétique
Krzesinski, Jean-Marie ULg

Conference (2003, November 26)

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See detailUn instrument politique au Nouvel Empire: l'oracle d'Amon de Karnak
Winand, Jean ULg

Scientific conference (2003, November 26)

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See detailEclairer naturellement les bâtiments
Reiter, Sigrid ULg

Scientific conference (2003, November 26)

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See detailEvolution des structures spatiales en région liégeoise : désurbanisation ou renouvellement urbain ?
Halleux, Jean-Marie ULg

Conference given outside the academic context (2003)

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See detailFrom Fantômas to The Dice Cup : Poetry and the Boundaries of Novelization
Delville, Michel ULg

in baetens, jan (Ed.) La novellisation (2003, November 23)

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See detailThe genus Biernatella Balinski, 1977 (Brachiopoda) from the late Frasnian of Belgium
Mottequin, Bernard ULg

in Dhondt, A. (Ed.) Academic Session in honour of Pierre Bultynck : RBINS, Brussels 22 November 2003 (2003, November 22)

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See detailLa parésie spastique du quadriceps fémoral : Une nouvelle entité clinique chez le veau de race Blanc Bleu Belge.
Touati, Kamal ULg; Müller, Philippe ULg; Gangl M. et al

in Annales de Médecine Vétérinaire (2003), 147

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See detailLa prise en charge cognitive de la démence
Adam, Stéphane ULg

Scientific conference (2003, November 22)

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