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See detailTreatment of urological complications related to aorto-iliac pathology and surgery
Bonnet, Pierre ULiege; Vandeberg, Colette ULiege; Limet, Raymond ULiege

in European Journal of Vascular and Endovascular Surgery (2003), 26(6), 657-664

Objectives. Proximity of ureters with iliac arteries makes them prone to damage by aorto-iliac pathology or surgery. The aim of this retrospective study is to analyse the incidence, the predisposing ... [more ▼]

Objectives. Proximity of ureters with iliac arteries makes them prone to damage by aorto-iliac pathology or surgery. The aim of this retrospective study is to analyse the incidence, the predisposing factors, and the optimal treatment Of ureteral stenosis (US) or leakages (UL). Design. Retrospective study. Material. Fiftyone ureteral lesions in 41 patients referred to the urologist in a fourteen years period in the same institution. Methods. Lesions are classified in three groups: A, preoperative; B, less than 3 months postoperatively; and C, more than 3 months postoperatively. Group A comprises 10 abdominal aortic aneurysm (AAA) patients; eight of the AAA are of the inflammatory type. Group B comprises 16 patients, 11 US and 9 UL. Group C comprises 15 patients and 15 US. Results. Endoureteral treatment was successful in most of the group B patients. Some of them, however, had to be submitted to secondary open surgery, so that the global success rate is 70% in group B. In group C, the response is poor following endourological treatment alone (12.5% success) and open surgery is more often needed (3 ureterolyses and 1 nephrectomy). Global success rate is 40%. Conclusion. Early diagnosis is associated to better results with less invasive procedure, late diagnosis is accompanied by a lower success rate of endourological treatment and requires more often primary open surgery. [less ▲]

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See detailHigh intraepithelial expression of estrogen and progesterone receptors in the transformation zone of the uterine cervix
Remoue, Franck; Jacobs, Nathalie ULiege; Miot, Valérie et al

in American Journal of Obstetrics and Gynecology (2003), 189(6), 1660-1665

OBJECTIVE: Because sex hormones may be involved in tumor initiation and progression, we analyzed the presence of hormone receptors in the transformation zone of the uterine cervix where the majority of ... [more ▼]

OBJECTIVE: Because sex hormones may be involved in tumor initiation and progression, we analyzed the presence of hormone receptors in the transformation zone of the uterine cervix where the majority of human papillomavirus infections and associated (pre)neoplastic lesions develop. STUDY DESIGN: By using 23 total hysterectomy samples from young women who underwent surgery for noncervical benign uterine disease, we analyzed, by immunohistologic techniques, the in situ expression of estrogen (E-2-R) and progesterone (P-4-R) receptors in the transformation zone and ectocervix of the same women. RESULTS: The expression of estrogen receptors and progesterone receptors is significantly higher in the transformation zone compared with the ectocervix. Immunohistochemical localization indicated that hormone receptor-positive cells are mainly observed in (para)basal and intermediate cell layers in both the transformation zone and ectocervical epithelium. When transformation zone samples were segregated into epithelial tissues with a predominantly mature (7/23 samples) or immature (16/23 samples) squamous metaplasia, only biopsy specimens with immature squamous metaplasia showed a significantly higher density of hormone receptor-positive cells compared with ectocervical epithelium (P < .01). CONCLUSION: Our results suggest that the cervical transformation zone may be at increased risk of the development of cancer because of a high sensitivity to sex hormone regulation. (Am J Obstet Gynecol 2003; 189:1660-5.) [less ▲]

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See detailSurvey of gastric lesions and blood pepsinogen levels in pigs in Burkina Faso
Banga-Mboko, H.; Tamboura, H.; Maes, D. et al

in Veterinary Research Communications (2003), 27(8), 595-602

The purpose of the study was to investigate the prevalence of gastric lesions and to provide diagnostic values for serum pepsinogen in non-infected pigs and in pigs with gastric disease. In an abattoir ... [more ▼]

The purpose of the study was to investigate the prevalence of gastric lesions and to provide diagnostic values for serum pepsinogen in non-infected pigs and in pigs with gastric disease. In an abattoir survey, the pepsinogen concentrations were measured in the serum from 62 non-infected pigs, 33 pigs with gastric lesions and 17 pigs infected with Hyostrongylus rubidus, using a specific radioimmunoassay (RIA). The mean (+/-SE) pepsinogen concentrations in the serum of non-infected pigs, in pigs with gastric ulcers, and in pigs with a heavy H. rubidus infection were 630.8 +/- 39.2 ng/ml, 1084.5 +/- 166.2 ng/ml and 1095.2 +/- 102.3 ng/ml, respectively (p < 0.05). Because of the higher concentrations of pepsinogen in the blood of pigs with gastric ulcers or parasitic infections, it is suggested that the measurement of serum pepsinogen by RIA may be an effective biochemical approach to the diagnosis of chronic gastric disorders in pigs. [less ▲]

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See detailLa violence d'un choc sans destinataire
Servais, Christine ULiege

in Communication et Langages (2003), 138

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See detailIntrahepatic synthesis of tumor necrosis factor-alpha related to cardiac surgery is inhibited by interleukin-10 via the Janus kinase (Jak)/signal transducers and activator of transcription (STAT) pathway.
Qing, Ma; Nimmesgern, Ariane; Heinrich, Peter C et al

in Critical Care Medicine (2003), 31(12), 2769-75

SUMMARY: OBJECTIVES To identify the signaling pathways involved in the anti-inflammatory shift of the cytokine balance due to hypothermia during cardiopulmonary bypass. DESIGN Experimental animal study ... [more ▼]

SUMMARY: OBJECTIVES To identify the signaling pathways involved in the anti-inflammatory shift of the cytokine balance due to hypothermia during cardiopulmonary bypass. DESIGN Experimental animal study. SETTING Department of experimental surgery of a university hospital. SUBJECTS Young pigs. INTERVENTIONS Animals underwent normothermic (37 degrees C) or hypothermic (28 degrees C) cardiopulmonary bypass (n = 6 each). Samples of liver tissue were taken before and 6 hrs after cardiopulmonary bypass. MEASUREMENTS AND MAIN RESULTS Intrahepatic expression of tumor necrosis factor-alpha, interleukin-10, inducible nitric oxide synthase, and suppressor of cytokine signaling-3 was detected by reverse transcriptase polymerase chain reaction and/or Western blotting. Concentrations of the inhibitory protein of nuclear factor-kappaB, IkappaB, and of the signal transducer and activator of transcription (STAT)-3 were measured by Western blotting. The DNA-binding activity of nuclear factor-kappaB and STAT-3 was assessed by electrophoretic mobility shift and supershift assays. Liver cell necrosis and apoptosis were assessed by histology and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay, respectively. Pigs operated on in hypothermia showed significantly higher intrahepatic concentrations of interleukin-10 and lower concentrations of tumor necrosis factor-alpha than the others. They also showed a lower percentage of hepatic cell necrosis but not of apoptosis. This anti-inflammatory reaction observed in the hypothermic group was associated with a higher expression of suppressor of cytokine signaling-3 and with increased activation of STAT-3. Activation of nuclear factor-kappaB and expression of inducible nitric oxide synthase, however, were not significantly different between both groups. CONCLUSION Our results show that hypothermia during cardiopulmonary bypass up-regulates interleukin-10 via STAT-3 activation, which in turn leads to the attenuation of tumor necrosis factor-alpha expression and to hepatic protection. [less ▲]

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See detailImpact du Percussionaire® et de la kinésithérapie respiratoire conventionnelle après chirurgie cardiaque : étude randomisée contrôlée
Kellens, Isabelle ULiege; Fraipont, V.; Weber, T. et al

in Réanimation (2003, December), 12(suppl 3), 243

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See detailCrural artery bypass with the autogenous greater saphenous vein
Van Damme, Hendrik ULiege; Zhang, Lihong ULiege; Baguet, E. et al

in European Journal of Vascular and Endovascular Surgery : The Official Journal of the European Society for Vascular Surgery (2003), 26(6), 635-642

Objective. To evaluate the long-term outcome of greater saphenous vein (GSV) infrapopliteal revascularisation in a single centre over a 10 year period. Material and methods. Fourty-one variables relating ... [more ▼]

Objective. To evaluate the long-term outcome of greater saphenous vein (GSV) infrapopliteal revascularisation in a single centre over a 10 year period. Material and methods. Fourty-one variables relating to a consecutive series of 90 crural artery GSV(76% in situ) bypasses in 81 patients (1990-2000) were analysed. The mean age of the 47 men and 34 women was 70 years. Limb-threatening ischaemia was present in 96% of cases, claudication in four patients. In 18 patients, surgery was 'redo'. Results. The perioperative mortality was 3% (n = 3). Patient survival was 54% at 4 years. Independent risk factors affecting survival were chronic renal insufficiency (p = 0.04), hypertension (p = 0.02), and ischaemic heart disease (p = 0.01). Four bypasses thrombosed within 30 days. Three of them could be successfully reopened. Mean follow-up was 39 months. The primary patency rate at 4 years was 80%. Chronic renal insufficiency revealed to be the single independent risk factor for graft thrombosis (p = 0.03, RR = 12.4). The 4-year limb salvage rate was 88%. No independent risk factor affecting the limb salvage could be identified. Conclusion. Crural artery revascularisation is a valuable option for the management of limb threatening infrapopliteal arterial occlusive disease. [less ▲]

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See detailClinical outcome following combination of cutting balloon angioplasty and coronary β-radiation for in-stent restenosis: A report from the RENO registry
Coucke, Philippe ULiege; Roguelov; Eeckhout

in Journal of Invasive Cardiology (The) (2003), 15(12), 706-709

At present, vascular brachytherapy is the only efficient therapy for in-stent restenosis. Nevertheless, edge restenosis often related to geographical miss has been identified as a major limitation of the ... [more ▼]

At present, vascular brachytherapy is the only efficient therapy for in-stent restenosis. Nevertheless, edge restenosis often related to geographical miss has been identified as a major limitation of the technique. The non-slippery cutting balloon has the potential to limit vascular barotraumas, which, together with low-dose irradiation at both ends of the radioactive source, are the prerequisite for geographical miss. This prospective study aimed to examine the efficacy of combining cutting balloon angioplasty and brachytherapy for in-stent restenosis. The Radiation in Europe NOvoste (RENO) registry prospectively tracked all patients who had been treated by coronary β-radiation with the Beta-Cath System (Novoste Corporation, Brussels, Belgium) but were not included in a randomized radiation trial. A subgroup of patients with in-stent restenosis treated by cutting balloon angioplasty and coronary β-radiation (group 1, n = 166) was prospectively defined, and clinical outcomes of patients at 6 months were compared with those of patients treated by conventional angioplasty and coronary β-radiation (group 2, n = 712). At 6-month follow-up, there was a significant difference between groups 1 and 2 in target vessel revascularization (10.2% versus 16.6% respectively; p = 0.04) and in the incidence of major adverse clinical events (MACE) including death, myocardial infarction, and revascularization (10.8% versus 19.2%; p = 0.01). This observation was confirmed by a multivariate analysis indicating a lower risk for MACE at 6 months (odds ratio: 0.49; confidence intervals: 0.27-0.88; p = 0.02). Compared to conventional angioplasty, cutting balloon angioplasty prior to coronary beta-radiation with the Beta-Cath System seems to improve the 6-month clinical outcome in patients with in-stent restenosis. [less ▲]

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See detailInverse Estimates of Anthropogenic Carbon Dioxide From Ocean Interior Carbon Measurements and Ocean General Circulation Models
Mikaloff Fletcher, S. E.; Gruber, N. P.; Jacobson, A. R. et al

Conference (2003, December)

The ocean is an important sink for atmospheric carbon dioxide, and the exchange of carbon dioxide between the atmosphere and ocean plays a critical role in determining the spatial distribution of ... [more ▼]

The ocean is an important sink for atmospheric carbon dioxide, and the exchange of carbon dioxide between the atmosphere and ocean plays a critical role in determining the spatial distribution of atmospheric carbon dioxide. However, there is still a great deal of uncertainty in both magnitude and regional patterns of anthropogenic uptake associated with estimates of oceanic carbon fluxes. Using a recently developed technique, exchange of anthropogenic carbon dioxide across the air-sea interface have been estimated from observations of dissolved inorganic carbon and nutrient concentrations and an Ocean General Circulation Model (OGCM) using a Green's function inverse modeling technique. Previous sensitivity studies have shown that model circulation error is an important source of error in the ocean inversion. In order to address the role of ocean circulation biases, inverse estimates of anthropogenic carbon air-sea gas exchange are presented using basis functions from a suite of seven different OGCM's. The robustness of the ocean inversion will be quantified and the effects of differences between approaches to modeling ocean circulation on the ocean carbon cycle will be explored. These results will be discussed in the context of recent atmospheric inverse estimates. [less ▲]

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See detailTribology of SiC/SiC Ceramic Matrix Composites in Liquid Oxygen in Relation to the Design of Hydrostatic Bearings
Bozet, Jean-Luc ULiege; NELIS, M.; LEUCHS, Martin et al

in Tribotest Journal (2003), 10(2), 105-115

This paper aims with the characterization of ceramic matrix composites for bearing applications in LOX. First, compatibility tests have been performed to assume the safety and feasibility of further ... [more ▼]

This paper aims with the characterization of ceramic matrix composites for bearing applications in LOX. First, compatibility tests have been performed to assume the safety and feasibility of further research operations. Then tribology tests were made on a pin-on-disc apparatus using LOX as working environment. The measurement of friction and wear allowed a comparison between different kinds of CMC and steel 440C materials. As a logical approach, a real geometry test rig is now being built up. The design of a hybrid journal bearing has been finished and the manufacturing of the rig components started. [less ▲]

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See detailNouvelles directives européennes pour le traitement de l'hypertension artérielle : place des associations faiblement dosées
Krzesinski, Jean-Marie ULiege

in Journal de Cardiologie = Tijdschrift voor Cardiologie (2003), (8), 295-299

Traiter l'hypertension artérielle est très rentable en terme de réduction du risque cardiovasculaire pour autant que l'on normalise la pression artérielle. L'utilisation d'emblée d'associations de ... [more ▼]

Traiter l'hypertension artérielle est très rentable en terme de réduction du risque cardiovasculaire pour autant que l'on normalise la pression artérielle. L'utilisation d'emblée d'associations de molécules de familles différentes mais à posologies très faibles vient d'être proposée par les nouvelles directives européennnes du traitement de l'hypertension. Ces associations très faiblement dosées tentent d'être rapidement efficaces chez un plus grand nombre d'hypertendus avec un minimum d'effets secondaires. Un rapport coût/efficacité faible en est un des avantages. [less ▲]

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See detailClinique phoniatrique
FINCK, Camille ULiege

Scientific conference (2003, December)

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See detailRésistances bactériennes aux antibiotiques : le cas des pathogènes respiratoires du bovin
Mainil, Jacques ULiege

Scientific conference (2003, December)

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See detailRight lobe living-related liver transplantation in a Jehovah's Witness
Detry, Olivier ULiege; De Roover, Arnaud ULiege; Kaba, Abdourahmane ULiege et al

in Transplant International (2003), 16(12), 895-896

Detailed reference viewed: 36 (15 ULiège)