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See detailStatut et tendances des effectifs d’éléphants dans les aires protégées de l’Est du Burkina Faso
Bouché, Philippe ULg; Lungren, Clark; Ouédraogo, Léonard

in Pachyderm (2002), 32

Le Burkina Faso abrite l’effectif d’éléphants de savane le plus important de toute l’Afrique de l’Ouest, là où cette espèce jouit d’une protection intégrale. Un recensement aérien par échantillon a été ... [more ▼]

Le Burkina Faso abrite l’effectif d’éléphants de savane le plus important de toute l’Afrique de l’Ouest, là où cette espèce jouit d’une protection intégrale. Un recensement aérien par échantillon a été mené dans le sud-est du Burkina Faso en avril et mai 2000. L’effectif total moyen atteignait 1.743 ± 648 éléphants, ce qui constitue la plus grande population d’éléphants de savane en Afrique de l’Ouest. La moyenne des groupes observés était de: 5,42 (Erreur standard = 11,68 animaux) (1 à 32 individus / groupe). La distribution des éléphants enregistrée confirme largement la distribution enregistrée les années précédentes. [less ▲]

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See detailComment je traite ... une polyarthrite rhumatoïde. L'avènement d'une nouvelle ère thérapeutique: les anticorps anti-TNF-alpha
Kaiser, Marie-Joëlle ULg; Malaise, Michel ULg

in Revue Médicale de Liège (2002), 57(8), 486-492

Rheumatoid arthritis (RA) is the most frequent autoimmune inflammatory arthropathy. Chronic synovial inflammation usually results in cartilage destruction, bone erosion and subsequent joint deformities ... [more ▼]

Rheumatoid arthritis (RA) is the most frequent autoimmune inflammatory arthropathy. Chronic synovial inflammation usually results in cartilage destruction, bone erosion and subsequent joint deformities with impaired physical function. These consequences are more or less delayed by standard disease-modifying antirheumatic drugs (DMARDs). A better knowledge of the basic mechanisms of the disease and new biomolecular tools led to the development of novel biological agents including TNF alpha blockers. TNF alpha is a key inflammatory cytokine that plays a critically important role in the pathogenesis of RA. TNF alpha blockers brought dramatic improvements in efficacy of RA treatment. Here we will review the pathophysiological elements of RA wich explain the therapeutic efficacy of these TNF alpha blockers and we will describe in details the molecules, Remicade (Infliximab) and Enbrel (Etanercept), wich will be very soon used in daily practice in Belgium. [less ▲]

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See detailEffect of deep digital flexor tendon orientation on magnetic resonance imaging signal intensity in isolated equine limbs - The magic angle effect
Busoni, Valeria ULg; Snaps, Frédéric ULg

in Veterinary Radiology & Ultrasound (2002), 43(5, Sep-Oct), 428-430

Ten normal equine isolated limbs were imaged using a knee coil in a 1.5 Tesla magnetic field, with short echo time sequences (TE < 15 ms). Magnetic resonance imaging was performed on each isolated limb in ... [more ▼]

Ten normal equine isolated limbs were imaged using a knee coil in a 1.5 Tesla magnetic field, with short echo time sequences (TE < 15 ms). Magnetic resonance imaging was performed on each isolated limb in different positions, with and without extension of the metacarpophalangeal joint. Deep digital flexor tendon orientation ranged from 20 to 60 degrees in relation to the static magnetic field. Increased intratendinous signal intensity was observed when the angle between the deep digital flexor tendon and the constant magnetic field approached 55 degrees ("magic angle"). The increased signal intensity was independent from extension of the metacarpophalangeal joint. Recognition of the magic angle phenomenon is essential for proper evaluation of magnetic resonance imaging studies of the equine foot. [less ▲]

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See detailÉcriture et système de prescription. L’exemple du “Lecteur du Petit Journal” (Zola, 1865)
Durand, Pascal ULg

in Jurt, J.; Einfalt, M. (Eds.) Le texte et le contexte. Analyses du champ littéraire français (XIXe et XXe siècle) (2002)

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See detailDes doutes nes apres le 11 septembre aux espoirs places dans l'euro....
Kulbertus, Henri ULg; Scheen, André ULg

in Revue Médicale de Liège (2002), 57(1), 1-2

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See detailCompte rendu de A. BRÄM, Das Andachtsbuch der Marie de Gavre
George, Philippe ULg

in Moyen Age (Le) (2002)

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See detailKinetic study of the acid hydrolysis of various oligofructose samples
Blecker, Christophe ULg; Fougnies, C.; Van Herck, J. C. et al

in Journal of Agricultural and Food Chemistry (2002), 50(6), 1602-1607

The kinetic of acid hydrolysis of five commercially available oligofructose samples used as food ingredients has been investigated as a function of the dry matter concentration, reaction pH, and ... [more ▼]

The kinetic of acid hydrolysis of five commercially available oligofructose samples used as food ingredients has been investigated as a function of the dry matter concentration, reaction pH, and temperature. The initial fructose release rate is found to be roughly proportional to the inverse of the average polymerization degree in number. A pseudo first order kinetic is found with respect to the fructosyl chain end concentration and to the proton concentration. Arrhenius plot is found to reasonably fit the data in a relatively wide temperature range (7-130 degreesC). The results allow the estimation of the fructose release rate in many foodstuff processing conditions. [less ▲]

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See detailLe statut juridique de la grève dans le secteur privé
Clesse, Jacques ULg

in La grève: recours aux tribunaux ou retour à la conciliation sociale (2002)

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See detailOn the specificity of cyclodextrin complexes detected by electrospray mass spectrometry
Gabelica, Valérie ULg; Galic, Nives; De Pauw, Edwin ULg

in Journal of the American Society for Mass Spectrometry (2002), 13(8), 946-953

alpha-cyclodextrin complexes with linear alpha,omega-dicarboxylic acids were investigated by electrospray mass spectrometry. These hydrophobic complexes are known to have an equilibrium binding constant ... [more ▼]

alpha-cyclodextrin complexes with linear alpha,omega-dicarboxylic acids were investigated by electrospray mass spectrometry. These hydrophobic complexes are known to have an equilibrium binding constant that increases with the diacid chain length. However, the electrospray mass spectrometry (ES-MS) spectra showed that the relative intensity of the complex did not vary significantly with chain length. This contradiction is caused by a contribution of nonspecific adducts to the signal of the complex in ES-MS. In order to estimate the contribution of nonspecific adducts to the total intensity of the complexes with alpha-cyclodextrin, the comparison was made between alpha-cyclodextrin and maltohexaose, the latter being incapable of making inclusion complexes in solution. The signal observed for complexes between diacids and maltohexaose can only result from nonspecific electrostatic aggregation, and is found to be more favorable with the shorter diacids. This is also supported by MS/MS experiments. A procedure is described which allows estimation of the contribution of the nonspecific complex in the spectra of the complexes with alpha-cyclodextrin by using the relative intensity of the complex with maltohexaose. The contribution of the specific complex to the total signal intensity is found to increase with the diacid chain length, which is in agreement with solution behavior. [less ▲]

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See detailSelf-adapting time integration management in crash-worthiness and sheet metal forming computations
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg

in International Journal of Vehicle Design (2002), 30(1-2), 67-114

Variable step strategies are especially well suited to deal with problems characterized by high non-linearity and contact/impact, and resolved with an implicit scheme. Both phenomena are typical of ... [more ▼]

Variable step strategies are especially well suited to deal with problems characterized by high non-linearity and contact/impact, and resolved with an implicit scheme. Both phenomena are typical of dynamic simulations of contact-impact problems, as well as sheet metal forming. Constant step size strategies do not give a satisfactory answer for this kind of problem, since it is very difficult, if not impossible, for the user to find an appropriate time step that does not lead to divergence nor generate extremely costly computations. An automatic time stepping algorithm is proposed, which takes into account the recent history of accelerations in the deformable bodies under consideration. More precisely, the adaptation algorithm is based on estimators of the integration error of the differential dynamic balance equations. This allows for adaptation of the step size to capture correctly the transient phenomena, with characteristic times which can range from relatively long (after contact, or during sheet metal forming) to very short (during contact-impact). thus ensuring precision while keeping the computation cost to a minimum. Furthermore, we will see that this strategy can be used in explicit schemes. Additionally, the proposed algorithm automatically takes decisions regarding the necessity of updating the tangent matrix or stopping the iterations, further reducing the computational costs especially, when the Augmented Lagrangian method is used. As an illustration of the capabilities of this algorithm, several numerical simulations (shock absorber devices for vehicle crash-worthiness or sheet metal forming) problems will be presented. Other simulations pertaining to the sheet metal forming for vehicle structures will also be investigated, thus demonstrating the versatility, the capabilities and the efficiency of the proposed strategy. [less ▲]

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See detailModeling of Thin Insulating Layers in Dual Magnetodynamic Formulations
Dular, Patrick ULg; Geuzaine, Christophe ULg

in Proceedings of the 10th IEEE Conference on Electromagnetic Field Computation (CEFC'2002) (2002)

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See detailDevelopment Of A Visual Method To Quantify The Gossypol Content In Cotton Seeds
Benbouza, H.; Lognay, Georges ULg; Palm, Rodolphe ULg et al

in Crop Science (2002), 42(6), 1937-1942

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See detailComparison of the collision-induced dissociation of duplex DNA at different collision regimes: Evidence for a multistep dissociation mechanism
Gabelica, Valérie ULg; De Pauw, Edwin ULg

in Journal of the American Society for Mass Spectrometry (2002), 13(1), 91-98

The dissociation mechanism of duplex DNA has been investigated in detail by collision-induced dissociation experiments at different collision regimes. MS/MS experiments were performed either in a ... [more ▼]

The dissociation mechanism of duplex DNA has been investigated in detail by collision-induced dissociation experiments at different collision regimes. MS/MS experiments were performed either in a quadrupole collision cell (hybrid quadrupole-TOF instrument) or in a quadrupole ion trap with different activation times and energies. In addition to the noncovalent dissociation of the duplex into the single strands, other covalent bond fragmentation channels were observed. Neutral base loss from the duplex is favored by slow activation. In fast activation conditions, however, the major reaction channel is the noncovalent dissociation into single strands, which is highly entropy-favored. Fast activation regimes can favor the entropy-driven noncovalent dissociation, while in slow heating conditions the competition with enthalpy-driven covalent fragmentation can completely hinder the dissociation of the complex. We also evidence that the noncovalent dissociation of DNA duplex is a multistep process involving a progressive unzipping, preferentially at terminal positions. This is proposed to be a general feature for complexes containing a high number of contributing interactions organized at the interface of the ligands. The overall (observed) dissociation kinetics of noncovalent complexes can therefore depend on a complicated mechanism for which a single transition state description of the kinetics is too simplistic. [less ▲]

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See detailIn vitro recovery of ATP-sensitive potassium channels in Beta-cells from patients with hyperinsulinism in infancy; effects of low temperature and BPDZ 154
Cosgrove, K. E.; Gonzalez, A. M.; Lee, A. T. et al

in Journal of Physiology (2002), 544

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See detailUsing word frequencies for testing equivalence between two DNA sequences
Jansen, I.; Van Steen, Kristel ULg; Molenberghs, G. et al

in Genetic Epidemiology (2002), 23

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See detailOn-line automated PLE and multi-column clean-up system for PCDD/Fs and PCB analysis in food samples
Focant, Jean-François ULg; Shirkhan, Hamid; De Pauw, Edwin ULg

in Organohalogen Compounds (2002), 55

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See detailTextes hagiographiques et méthodes quantitatives
Philippart de Foy, Caroline ULg

Scientific conference (2002)

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See detailDynamic T cell receptor clonotype changes in synovial tissue of patients with early rheumatoid arthritis: effects of treatment with cyclosporin A (Neoral)
VanderBorght, Ann; De Keyser, Filip; Geusens, Piet et al

in Journal of Rheumatology (2002), 29(3), 416-426

OBJECTIVE: To study T cell receptor (TCR) repertoire changes in synovial membrane over a 16 week period in patients with early rheumatoid arthritis (RA); and to study the influence of cyclosporin A (CSA ... [more ▼]

OBJECTIVE: To study T cell receptor (TCR) repertoire changes in synovial membrane over a 16 week period in patients with early rheumatoid arthritis (RA); and to study the influence of cyclosporin A (CSA) on TCR repertoire in a subgroup of these patients. METHODS: Synovial tissue biopsies and paired blood samples were obtained from 12 patients with early RA at 2 time points. Seven patients were treated with CSA (Neoral-Sandimmun, 3 mg/kg/day) and 5 patients with placebo for 16 weeks. TCR V gene repertoires were analyzed by semiquantitative PCR-ELISA. CDR3 spectratyping and sequence analysis was used to compare TCR clonotype distributions. RESULTS: TCR-specific mRNA was detected in all synovial tissue biopsies at the first sampling, but in only 8/12 biopsies 16 weeks later (4/7 CSA group, 4/5 placebo group). Overrepresented TCR BV genes were found in biopsies of 10/12 patients at the first time point, and in 7/12 patients after 16 weeks (3/7 CSA, 4/5 placebo). CDR3 sequence analysis revealed dynamic repertoire changes with only a few persisting clonotypes in the synovial tissue of placebo controls. Persisting T cell clonotypes were more frequently found in the synovial tissue of CSA treated patients compared to the placebo group. CONCLUSION: These data suggest a dynamic process of T cell recruitment in the joints of RA patients. This process, possibly due to activation and subsequent infiltration of new T cell clones, apparently is influenced by CSA treatment. Synovial tissue T cells were no longer detected after 16 weeks' CSA treatment in 3 patients. In the other CSA treated patients, new T cell clones infiltrated, while other clones were persistently represented in the joints. These data may have important consequences for the design of T cell targeted therapies for RA. [less ▲]

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