References of "2002"
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See detailResults of a whole genome scan targeting QTL for growth and carcass traits in a Pietrain x Large White intercross
Nezer, C.; Moreau, L.; Wagenaar, D. et al

in Genetics, Selection, Evolution (2002), 34(3, May-Jun), 371-387

We herein report the results of a whole genome scan performed in a Pietrain x Large White intercross counting 525 offspring to map QTL influencing economically important growth and carcass traits. We ... [more ▼]

We herein report the results of a whole genome scan performed in a Pietrain x Large White intercross counting 525 offspring to map QTL influencing economically important growth and carcass traits. We report experiment-wide significant lod scores (> 4.6) for meatiness and fat deposition on chromosome SSC2, and for average daily gain and carcass length on chromosome SSC7. Additional suggestive lod scores (> 3.3) for fat deposition are reported on chromosomes SSC1, SSC7 and SSC13. A significant dominance deviation was found for the QTL on SSC1, while the hypothesis of an additive QTL could not be rejected for the QTL on SSC7 and SSC13. No evidence for imprinted QTL could be found for QTL other than the one previously reported on SSC2. [less ▲]

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See detailSimultaneous mining of linkage and linkage disequilibrium to fine map quantitative trait loci in outbred half-sib pedigrees: Revisiting the location of a quantitative trait locus with major effect on milk production on bovine chromosome 14
Farnir, Frédéric ULg; Grisart, B.; Coppieters, Wouter ULg et al

in Genetics (2002), 161(1), 275-287

A maximum-likelihood QTL mapping method that simultaneously exploits linkage and linkage disequilibrium and that is applicable in outbred half-sib pedigrees is described. The method is applied to fine map ... [more ▼]

A maximum-likelihood QTL mapping method that simultaneously exploits linkage and linkage disequilibrium and that is applicable in outbred half-sib pedigrees is described. The method is applied to fine map a QTL with major effect on milk fat content in a 3-cM marker interval on proximal BTA14. This proximal location is confirmed by applying a haplotype-based association method referred to as recombinant ancestral haplotype analysis. The origin of the discrepancy between the QTL position derived in this work and that of a previous analysis is examined and shown to be due to the existence of distinct marker haplotypes associated with QTL alleles having large substitution effects. [less ▲]

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See detailPositional candidate cloning of a QTL in dairy cattle: Identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition
Grisart, B.; Coppieters, Wouter ULg; Farnir, Frédéric ULg et al

in Genome Research (2002), 12(2), 222-231

We recently mapped a quantitative trait locus (QTL) with a major effect on milk composition-particularly fat content-to the centromeric end of bovine chromosome 14. We subsequently exploited linkage ... [more ▼]

We recently mapped a quantitative trait locus (QTL) with a major effect on milk composition-particularly fat content-to the centromeric end of bovine chromosome 14. We subsequently exploited linkage disequilibrium to refine the map position of this QTL to a 3-cM chromosome interval bounded by microsatellite markers BULGE13 and BULGE09. We herein report the positional candidate cloning of this QTL, involving (I) the construction of a BAC contig spanning the corresponding marker interval, (2) the demonstration that a very strong candidate gene, acylCoA:diacylglycerol acyltransferase (DGATf), maps to that contig, and (3) the identification of a nonconservative K232A substitution in the DGAT1 gene with a major effect on milk fat content and other milk characteristics. [less ▲]

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See detailCa2+/calmodulin dependent protein kinase regulates GABA activated Cl- current in cockroach dorsal unpaired median neurons
Alix, Philippe ULg; Grolleau, F; Hue, B

in Journal of Neurophysiology (2002), 87

We studied gamma-aminobutyric acid (GABA)-mediated currents in short-term cultured dorsal unpaired median (DUM) neurons of cockroach Periplaneta americana using the whole cell patch-clamp technique in ... [more ▼]

We studied gamma-aminobutyric acid (GABA)-mediated currents in short-term cultured dorsal unpaired median (DUM) neurons of cockroach Periplaneta americana using the whole cell patch-clamp technique in symmetrical chloride solutions. All DUM neurons voltage-clamped at -50 mV displayed inward currents (I(GABA)) when 10(-4) M of GABA was applied by pneumatic pressure-ejection pulses. The semi-logarithmic curve of I(GABA) amplitude versus the ejection time yielded a Hill coefficient of 4.0. I(GABA) was chloride (Cl-) because the reversal potential given by the current-voltage (I-V) curve varied according to the value predicted by the Nernst equation for Cl- dependence. In addition, I(GABA) was almost completely blocked by bath application of the chloride channel blockers picrotoxin (PTX) or 3,3-bis(trifluoromethyl)bicyclo-[2,2,1]heptane-2,2-diacarbonitrile (BIDN). The I-V curve for I(GABA) displayed a unexpected biphasic aspect and was best fitted by two linear regressions giving two slope conductances of 35.6 +/- 2.1 and 80.9 +/- 4.1 nS for potentials ranging from 0 to -30 and -30 to -70 mV, respectively. At -50 mV, the current amplitude was decreased by cadmium chloride (CdCl2, 10(-3) M) and calcium-free solution. The semi-logarithmic curve for CdCl2-resistant I(GABA) gave a Hill coefficient of 2.4. Hyperpolarizing voltage step from -50 to -80 mV was known to increase calcium influx through calcium-resting channels. According to this protocol, a significant increase of I(GABA) amplitude was observed. However, this effect was never obtained when the same protocol was applied on cell body pretreated with CdCl2. When the calmodulin blocker N-(6-aminohexyl)-5-chloro-1-naphtalene-sulfonamide or the calcium-calmodulin-dependent protein kinase blocker 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine (KN-62) was added in the pipette solution, I(GABA) amplitude was decreased. Pressure ejection application of the cis-4-aminocrotonic acid (CACA) on DUM neuron cell body held at -50 mV, evoked a Cl- inward current which was insensitive to CdCl2. The Hill plot yielded a Hill coefficient of 2.3, and the I-V curve was always linear in the negative potential range with a slope conductance of 32.4 +/- 1.1 nS. These results, similar to those obtained with GABA in the presence of CdCl2 and KN-62, indicated that CACA activated one subtype of GABA receptor. Our study demonstrated that at least two distinct subtypes of Cl--dependent GABA receptors were expressed in DUM neurons, one of which is regulated by an intracellular Ca2+-dependent mechanism via a calcium-dependent protein kinase. The consequences of the modulatory action of Ca2+ in GABA receptors function and their sensitivity to insecticide are discussed. [less ▲]

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See detailMesoporous zirconium oxides: An investigation of physico-chemical synthesis parameters
Blin, J. L.; Gigot, L.; Léonard, Alexandre ULg et al

in Studies in Surface Science and Catalysis (2002), 141

A systematic kinetic study of mesoporous zirconia formation has been performed in order to optimize the synthesis conditions without addition of structure stabilizing agents such as sulfate or phosphate ... [more ▼]

A systematic kinetic study of mesoporous zirconia formation has been performed in order to optimize the synthesis conditions without addition of structure stabilizing agents such as sulfate or phosphate anions. We have investigated in particular the effect of synthesis time and temperature. On the basis of TEM, SEM XRD and N 2 adsorption-desorption results, a synthesis mechanism has been proposed. Low temperature or short duration afford supermicroporous materials and continuation of hydrothermal treatment makes the walls separating adjacent pores break down allowing the transformation to mesopores. The obtained materials have a uniform pore size and their surface can reach 400m 2/g. However, if hydrothermal treatment is performed at too high temperatures or for too long durations, mesoporous compounds are no longer obtained, but thermodynamically more stable crystalline zirconium oxides with very low specific surface area, namely the tetragonal and monoclinic forms, are the final phases that are more likely to appear. [less ▲]

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See detailBriefe an Goethe. Gesamtausgabe in Regestform. Bd. 6.1 und 6.2 (Rezension)
Viehöver, Vera ULg

in Germanistik (2002), 43(3/4), 5288

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See detailAcute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase.
Hafezi-Moghadam, Ali; Simoncini, Tommaso; Yang, Zequan et al

in Nature Medicine (2002), 8(5), 473-9

Corticosteroids have been shown to exert beneficial effects in the treatment of acute myocardial infarction, but the precise mechanisms underlying their protective effects are unknown. Here we show that ... [more ▼]

Corticosteroids have been shown to exert beneficial effects in the treatment of acute myocardial infarction, but the precise mechanisms underlying their protective effects are unknown. Here we show that high-dose corticosteroids exert cardiovascular protection through a novel mechanism involving the rapid, non-transcriptional activation of endothelial nitric oxide synthase (eNOS). Binding of corticosteroids to the glucocorticoid receptor (GR) stimulated phosphatidylinositol 3-kinase and protein kinase Akt, leading to eNOS activation and nitric oxide dependent vasorelaxation. Acute administration of pharmacological concentrations of corticosteroids in mice led to decreased vascular inflammation and reduced myocardial infarct size following ischemia and reperfusion injury. These beneficial effects of corticosteroids were abolished by GR antagonists or eNOS inhibitors in wild-type mice and were completely absent in eNOS-deficient (Nos3(-/-)) mice. The rapid activation of eNOS by the non-nuclear actions of GR, therefore, represents an important cardiovascular protective effect of acute high-dose corticosteroid therapy. [less ▲]

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See detailHsp27 in the nervous system: expression in pathophysiology and in the aging brain.
Krueger-Naug, A. M. R.; Plumier, Jean-Christophe ULg; Hopkins, D. A. et al

in Progress in Molecular and Subcellular Biology (2002), 28

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See detailEveil des sociétés civiles en milieu urbain et organisations non gouvernementales: les exemples de Cotonou et de Lubumbashi
Pirotte, Gautier ULg; Poncelet, Marc ULg

in Autrepart : Revue de Sciences Sociales au Sud (2002), (23), 73-88

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See detailCompte rendu de A. BRÄM, Das Andachtsbuch der Marie de Gavre
George, Philippe ULg

in Moyen Age (Le) (2002)

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See detailSeasonal changes in the songbird brain are modulated by song performance via testosterone-dependent and independent action
Sartor, Jennifer J; Charlier, Thierry ULg; Pytte, Caroline L et al

Poster (2002)

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See detailÉcriture et système de prescription. L’exemple du “Lecteur du Petit Journal” (Zola, 1865)
Durand, Pascal ULg

in Jurt, J.; Einfalt, M. (Eds.) Le texte et le contexte. Analyses du champ littéraire français (XIXe et XXe siècle) (2002)

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See detailRapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids.
Limbourg, Florian P; Huang, Zhihong; Plumier, Jean-Christophe ULg et al

in Journal of Clinical Investigation (2002), 110(11), 1729-38

Many cellular responses to corticosteroids involve the transcriptional modulation of target genes by the glucocorticoid receptor (GR). A rapid, non-nuclear effect of GR was found to mediate ... [more ▼]

Many cellular responses to corticosteroids involve the transcriptional modulation of target genes by the glucocorticoid receptor (GR). A rapid, non-nuclear effect of GR was found to mediate neuroprotection. High-dose corticosteroids (20 mg/kg intraperitoneally), given within 2 hours of transient cerebral ischemia, acutely increased endothelial nitric oxide synthase (eNOS) activity, augmented regional cerebral blood flow (CBF) by 40% to 50%, and reduced cerebral infarct size by 32%. These neuroprotective effects of corticosteroids were abolished by the GR antagonist RU486 and by inhibition of phosphatidylinositol 3-kinase (PI3K), and were absent in eNOS(-/-) mice. To determine the mechanism by which GR activated eNOS, we measured the effect of corticosteroids on PI3K and the protein kinase Akt. In a ligand-dependent manner, GR activated PI3K and Akt in vitro and in vivo caused NO-dependent vasodilation, which was blocked by cotreatment with RU486 or the PI3K inhibitor LY294002 but not by transcriptional inhibitors. Indeed, a mutant GR, which cannot dimerize and bind to DNA, still activated PI3K and Akt in response to corticosteroids. These findings indicate that non-nuclear GR rapidly activates eNOS through the PI3K/Akt pathway and suggest that this mechanism mediates the acute neuroprotective effects of corticosteroids through augmentation of CBF. [less ▲]

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See detailAu-delà des performances des jeunes de 15 ans, un système éducatif se profile... : premiers résultats de PISA 2000
Lafontaine, Dominique ULg

Report (2002)

Le Programme International de l'OCDE pour le Suivi des Acquis des élèves de 15 ans (PISA 2000) a évalué les élèves dans 3 domaines, la lecture/écriture ('littératie'), la culture mathématique et la ... [more ▼]

Le Programme International de l'OCDE pour le Suivi des Acquis des élèves de 15 ans (PISA 2000) a évalué les élèves dans 3 domaines, la lecture/écriture ('littératie'), la culture mathématique et la culture scientifique, en axant cette évaluation sur leur capacité de résolution de problèmes dans des contextes proches de la vie quotidienne. [less ▲]

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See detailLa mémoire des morts à Stavelot-Malmedy. Des origines au XIIe siècle
George, Philippe ULg

in Malmedy Folklore (2002)

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See detailHeat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice.
McMillan, D Randy; Christians, Elisabeth; Forster, Michael et al

in Molecular & Cellular Biology (2002), 22(22), 8005-14

Members of the heat shock factor (HSF) family are evolutionarily conserved regulators that share a highly homologous DNA-binding domain. In mammals, HSF1 is the main factor controlling the stress ... [more ▼]

Members of the heat shock factor (HSF) family are evolutionarily conserved regulators that share a highly homologous DNA-binding domain. In mammals, HSF1 is the main factor controlling the stress-inducible expression of Hsp genes while the functions of HSF2 and HSF4 are less clear. Based on its developmental profile of expression, it was hypothesized that HSF2 may play an essential role in brain and heart development, spermatogenesis, and erythroid differentiation. To directly assess this hypothesis and better understand the underlying mechanisms that require HSF2, we generated Hsf2 knockout mice. Here, we report that Hsf2(-/-) mice are viable and fertile and exhibit normal life span and behavioral functions. We conclude that HSF2, most probably because its physiological roles are integrated into a redundant network of gene regulation and function, is dispensable for normal development, fertility, and postnatal psychomotor function. [less ▲]

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