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See detailHepatic insulin resistance in obese non-diabetic subjects and in type 2 diabetic patients.
Paquot, Nicolas ULg; Scheen, André ULg; Dirlewanger, Mirjam et al

in Obesity Research (2002), 10(3), 129-34

OBJECTIVE: Obese non-diabetic patients are characterized by an extra-hepatic insulin resistance. Whether obese patients also have decreased hepatic insulin sensitivity remains controversial. RESEARCH ... [more ▼]

OBJECTIVE: Obese non-diabetic patients are characterized by an extra-hepatic insulin resistance. Whether obese patients also have decreased hepatic insulin sensitivity remains controversial. RESEARCH METHODS AND PROCEDURES: To estimate their hepatic insulin sensitivity, we measured the rate of exogenous insulin infusion required to maintain mildly elevated glycemia in obese patients with type 2 diabetes, obese non-diabetic patients, and lean control subjects during constant infusions of somatostatin and physiological low-glucagon replacement infusions. To account for differences in insulin concentrations among the three groups of subjects, an additional protocol was also performed in healthy lean subjects with higher insulin infusion rates and exogenous dextrose infusion. RESULTS: The insulin infusion rate required to maintain glycemia at 8.5 mM was increased 4-fold in obese patients with type 2 diabetes and 1.5-fold in obese non-diabetic patients. The net endogenous glucose production (measured with 6,6-(2)H(2)-glucose) and total glucose output (measured with 2-(2)H(1)-glucose) were approximately 30% lower in the patients than in the lean subjects. Net endogenous glucose production and total glucose output were both markedly increased in both groups of obese patients compared with lean control subjects during hyperinsulinemia. DISCUSSION: Our data indicate that both obese non-diabetic and obese type 2 diabetic patients have a blunted suppressive action of insulin on glucose production, indicating hepatic and renal insulin resistance. [less ▲]

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See detailAnalyses dendrochronologiques de la maison dite Nimax et de la maison dite Steiler
Hoffsummer, Patrick ULg; Eeckhout, Jérôme ULg; Houbrechts, David ULg

in Zimmer, John (Ed.) Aux origines de la Ville de Luxembourg (2002)

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See detailEvidence for a persistent and extensive greening trend in Eurasia inferred from satellite vegetation index data.
Bogaert, Jan ULg; Zhou, L; Tucker, C J et al

in Journal of Geophysical Research (2002), 107(D11),

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See detailLe fédéralisme africain
Kabamba, Bob ULg

Learning material (2002)

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See detailChoice of probing site for estimation of carcass lean percentage in Piétrain pig using the real-time ultrasound
Youssao, A. K. L.; Verleyen, Vincent ULg; Michaux, Charles ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(4), 195-200

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See detailL'intensité des soins en gériatrie : élaboration d'un document de réflexion
Petermans, Jean ULg

in Revue Médicale de Bruxelles (2002), 23

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See detailWeetjes 2 : grammaticale terminologie
Vromans, Joseph ULg

Software (2002)

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See detailLe droit patrimonial de la famille sans préjugés. 1. Le droit des régimes matrimoniaux en pratique
Leleu, Yves-Henri ULg; Casman, Hélène; Verbeke, Alain

Book published by Kluwer (2002)

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See detailA multistage field test of wheelchair users for evaluation of fitness and prediction of peak oxygen consumption
Vanderthommen, Marc ULg; Francaux, M.; Colinet, Cédrik et al

in Journal of Rehabilitation Research & Development (2002), 39(6, Nov-Dec), 685-692

An incremental multistage field test (MFT) for wheelchair users was developed to evaluate physical fitness and predict peak oxygen consumption (VO2). Using auditory feedback, the participants (n = 37 ... [more ▼]

An incremental multistage field test (MFT) for wheelchair users was developed to evaluate physical fitness and predict peak oxygen consumption (VO2). Using auditory feedback, the participants (n = 37) were directed to wheel around an octagonal course, increasing their velocity every minute until exhaustion. Wheelchair velocity and metabolic parameters were recorded with the use of a speedometer and a portable spirometer system. The average number of exercise levels performed (MFT score) was 9.17 +/- 5.81, resulting in a peak heart rate (HR) of 99.0 +/- 13.9% of the theoretical maximum. A test-retest analysis (n = 10) showed that the MFT was reliable regarding MFT score, peak VO2, and peak HR reached. Stepwise multiple regression based on individual, wheelchair, propulsion technique, and physiological parameters revealed that the MFT score was the best and only predictor of peak VO2 (mL/min/kg) (= 18.03 + 0.78 MFT score, r(2) = 0.59). The MFT assesses wheelchair mobility and estimates peak VO2 encountered during the test. [less ▲]

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See detailAnalysis Of The C-Terminal Membrane Anchor Domains Of Hepatitis C Virus Glycoproteins E1 And E2: Toward A Topological Model
Charloteaux, Benoît ULg; Lins, Laurence ULg; Moereels, H. et al

in Journal of Virology (2002), 76(4), 1944-58

The hepatitis C virus (HCV) glycoproteins E1 and E2 should be anchored in the viral membrane by their C-terminal domains. During synthesis, they are translocated to the endoplasmic reticulum (ER) lumen ... [more ▼]

The hepatitis C virus (HCV) glycoproteins E1 and E2 should be anchored in the viral membrane by their C-terminal domains. During synthesis, they are translocated to the endoplasmic reticulum (ER) lumen where they remain. The 31 C-terminal residues of the E1 protein and the 29 C-terminal residues of the E2 protein are implicated in the ER retention. Moreover, the E1 and E2 C termini are implicated in E1-E2 heterodimerization. We studied the E1 and E2 C-terminal sequences of 25 HCV strains in silico using molecular modeling techniques. We conclude that both C-terminal domains should adopt a similar and peculiar configuration: one amphipathic alpha-helix followed by a pair of transmembrane beta-strands. Several three-dimensional (3-D) models were generated. After energy minimization, their ability to interact with membranes was studied using the molecular hydrophobicity potentials calculation and the IMPALA procedure. The latter simulates interactions with a membrane by a Monte Carlo minimization of energy. These methods suggest that the beta-hairpins could anchor the glycoproteins in the ER membrane at least transiently. Anchoring could be stabilized by the adsorption of the nearby amphipathic alpha-helices at the membrane surface. The 3-D models correlate with experimental results which indicate that the E1-E2 transmembrane domains are involved in the heterodimerization and have ER retention properties. [less ▲]

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See detailLogique et limites de terroir, une perspective sociologique de la production à la consommation
Stassart, Pierre M ULg

in Actes de la journée d'étude BAMST, les produits de viande, les enjeux de la qualité (2002)

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See detailPresence in bovine enteropathogenic (EPEC) and enterohaemorrhagic (EHEC) Escherichia coli of genes encoding for putative adhesins of human EHEC strains
Szalo, Ioan Mihai ULg; Goffaux, Frédéric; Pirson, Vinciane et al

in Research in Microbiology (2002), 153(10), 653-658

Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC) infections are characterised by the formation of attaching and effacing lesions on intestinal epithelial cells. The first step of ... [more ▼]

Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC) infections are characterised by the formation of attaching and effacing lesions on intestinal epithelial cells. The first step of EPEC and EHEC pathogenesis involves the initial adherence of the bacterium to the intestinal epithelium. A collection of bovine EPEC and EHEC strains belonging to different serogroups was tested by colony blot hybridization with gene probes for putative adhesins (BFPA, LPFA, IHA, LIFA) of human EPEC and EHEC, and also for fimbrial and afimbrial adhesins (AFA8, F17, Cs31A) of bovine necrotoxigenic E. coli (NTEC). In the bovine EPEC and EHEC strains tested, sequences homologous to lifA, ihA, and lpfA genes were detected, sometimes in association with particular serogroups. Bovine O26 EPEC also possessed a sequence homologous to a gene of the clp operon, coding for the CS31A adhesin, associated with bovine NTEC. Overall results showed that different genes encoding for putative adhesins of human EHEC strains are present in bovine EPEC and EHEC strains, but not one of them is present in all strains. [less ▲]

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See detailBMD and fracture effects of monofluorophosphate (MFP) combined with raloxifene (RLX) as compared to MFP alone in postmenopausal women with low bone mass
Reginster, Jean-Yves ULg; Felsenberg, D.; Gluer, C. C. et al

in Osteoporosis International (2002), 13(S1), 18-19

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See detailAnalytical study of the interaction between bending and axial force in bolted joints
Boissonnade, N.; Jaspart, Jean-Pierre ULg; Muzeau, J. P. et al

in Proceedings of the Third European Conference on Steel Structures (EUROSTEEL) (2002)

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