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See detailComparison of plasma cardiac troponins T and I in chronically hemodialyzed patients in relation to cardiac status and age
Chapelle, Jean-Paul ULg; Dubois, Bernard ULg; Bovy, Christophe ULg et al

in Clinical Chemistry & Laboratory Medicine (2002), 40(3), 240-245

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See detailEffects on rat pancreatic B-cells and rat aorta rings of 4,6-disubstituted 2,2-dimethylchromans structurally related to the potassium channel opener cromakalim
Sebille, S.; Becker, B.; Antoine, M.-H. et al

in Fundamental & Clinical Pharmacology (2002), 16

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See detailSystème SDC - Studio Digital Collaboratif
Leclercq, Pierre ULg; Safin, Stéphane ULg; Vandamme, Jean-François et al

Software (2002)

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See detailCompétences Relationnelles et Métamorphose des Organisations
Froehlicher, Thomas ULg; Schmidt, Géraldine; Kuhn, Anthony

Book published by ESKA (2002)

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See detailPerspectives de dialogue entre des neuromédiateurs et les kératinocytes.
Pierard-Franchimont, Claudine ULg; Faska, N.; Nikkels, Arjen ULg et al

in Dermatologie Actualité (2002), 65

Les neuromédiateurs contrôlant l’activité de l’axe hypothalamo-hypophysaire sont aussi exprimés dans la peau. D’autres neuromédiateurs liés au stress le sont également. En fait, près d’une vingtaine de ... [more ▼]

Les neuromédiateurs contrôlant l’activité de l’axe hypothalamo-hypophysaire sont aussi exprimés dans la peau. D’autres neuromédiateurs liés au stress le sont également. En fait, près d’une vingtaine de ces molécules sont synthétisées in situ et sont connues pour avoir des récepteurs spécifiques et exprimer une activité biologique dans cet organe. Certaines exercent un impact fonctionnel sur les kératinocytes. Il s’agit en fait de systèmes paracrines neuro-kératinocytaires et autocrines par lesquels les kératinocytes expriment de nombreux récepteurs pour les neuromédiateurs qu’ils libèrent eux-mêmes. [less ▲]

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See detailSur la concurrence entre "relatifs" et "démonstratifs de liaison" chez les historiens latins : l'exemple de Tacite
Longrée, Dominique ULg

in Bolkestein, Machtelt; Pinkster, Harm; Kroon, Caroline (Eds.) et al Theory and description in Latin linguistics, Selected papers from the Eleventh International Colloquium on Latin Linguistics, Amsterdam, June 24-29, 2001 (2002)

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See detailApproche clinique des ictères et des suspicions d’insuffisance hépatique aiguë chez le cheval : une étude rétrospective sur 40 cas
Amory, Hélène ULg; Sandersen, Charlotte ULg; Delguste, Catherine ULg et al

in Proceedings of the Annual meeting of the French Equine Veterinary Association (AVEF) (2002)

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See detailOncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase
Lefebvre, Laurent; Vanderplasschen, Alain ULg; Ciminale, Vincenzo et al

in Journal of Virology (2002), 76(3), 1400-1414

G4 and p13(II) are accessory proteins encoded by the X region of bovine leukemia virus and human T-cell leukemia virus type 1 (HTLV-1), respectively. Disruption of the G4 and p13(II) open reading frames ... [more ▼]

G4 and p13(II) are accessory proteins encoded by the X region of bovine leukemia virus and human T-cell leukemia virus type 1 (HTLV-1), respectively. Disruption of the G4 and p13(II) open reading frames interferes with viral spread in animal model systems, indicating that the corresponding proteins play a key role in viral replication. In addition, G4 is oncogenic in primary cell cultures and is absolutely required for efficient onset of leukemogenesis in sheep. To gain insight into the function of these proteins, we utilized the yeast two-hybrid system to identify protein partners of G4. Results revealed that G4 interacts with farnesyl pyrophosphate synthetase (FPPS), a protein involved in the mevalonate/squalene pathway and in synthesis of FPP, a substrate required for prenylation of Ras. The specificity of the interaction was verified by glutathione S-transferase (GST) pull-down assays and by coimmunoprecipitation experiments. Furthermore, confocal microscopy showed that the subcellular localization of G4 was profoundly affected by FPPS. The G4 protein itself was not prenylated, at least in rabbit reticulocyte lysate-based assays. The domain of G4 required for binding to FPPS was restricted to an amphipathic alpha-helix rich in arginine residues. Subtle mutation of this alpha-helix abrogated G4 oncogenic potential in vitro, providing a biological relevance for FPPS-G4 complex formation in cells. Finally, HTLV-1 p13(II) was also found to specifically interact with FPPS (in yeast as well as in GST pull-down assays) and to colocalize with G4 in mitochondria, suggesting a functional analogy between these oncoviral accessory proteins. Identification of FPPS as a molecular partner for p13(II) and G4 accessory proteins opens retrovirus-induced leukemia. [less ▲]

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See detailLes effets du transfert d'entreprise
Kefer, Fabienne ULg

in Rendez-vous sociaux de l'UCM (2002)

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See detailNonlinear thin shell finite element for steel and concrete structures subjected to fire: theoretical development
Talamona, Didier; Franssen, Jean-Marc ULg

in Journal of Applied Fire Science (2002), 11(4), 291-310

This article describes the features of a quadrilateral thin shell element, based on Marguerre's theory that has ben implemented in the finite element program SAFIR (from the University of Liege.) The ... [more ▼]

This article describes the features of a quadrilateral thin shell element, based on Marguerre's theory that has ben implemented in the finite element program SAFIR (from the University of Liege.) The element has four nodes (one at each corner) and each node has six degrees of freedom, i.e., three translations and three rotations (the sixth degree of freedom is a true one, which can be assimilated to the in-plane rotation.) This article presents some theoretical developments regarding the element formulation. The algorithm strategies for isotropic material (steel for example) and non-isotropic material 'concrete) and their modifications for elevated temperatures are described. Two verifications examples are presented (the patch test and Lee's frame at elevated temperatures). [less ▲]

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See detailUne dorsalgie malheureusement tenace
Malaise, Michel ULg; Kaye, Olivier; Radermecker, Maurice ULg et al

in Revue Médicale de Liège (2002), 57(5), 270-273

The etiological diagnosis of chronic thoracic pain is wide, from benign mechanical disorders to tumors. Reaching the exact diagnosis in often time consuming. Despite the availability of new techniques of ... [more ▼]

The etiological diagnosis of chronic thoracic pain is wide, from benign mechanical disorders to tumors. Reaching the exact diagnosis in often time consuming. Despite the availability of new techniques of imagery, a meticulous clinical history and physical examination remain mandatory. They will lead the exploration. Idiopathic intercostal neuralgia does not exist. [less ▲]

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See detailTIC et métiers en émergence: une approche compréhensive de la constitution de nouvelles logiques professionnelles
Zune, Marc; Pichault, François ULg; Rorive, Brigitte

in Kalika, Michel (Ed.) E-GRH : évolution ou révolution ? (2002)

Proposition of methodological criteria likely to define emerging jobs in the field of information technologies.

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See detailEinsatz der quantitativen Ultrasonometrie in der Knochendiagnostik beim Pferd
Carstanjen, B; Lepage, OM; Detilleux, Johann ULg et al

Poster (2002)

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See detailThe plant pathogenesis-related PR-10 proteins
Elbez, Mounira; Kevers, Claire ULg; Hamdi, Saïd et al

in Acta Botanica Gallica : Bulletin de la Société Botanique de France (2002), 149(4), 415-444

The PR-10 protein family contains proteins related to pathogenesis and allergenic proteins. They are acidic proteins, with an intracellular localization, usually members of a multigene family and ... [more ▼]

The PR-10 protein family contains proteins related to pathogenesis and allergenic proteins. They are acidic proteins, with an intracellular localization, usually members of a multigene family and ubiquitous among plant kingdom. They contain a highly conserved motif, identified as a phosphate binding site. Even if the biological function of these proteins is still unknown, many indicators seem to favour the hypothesis of an RNAse activity. Moreover, one of them seems to be a cytokinin specific binding protein. Besides, PR-10 protein expression induction under cytokinin treatment was observed with the Catharanthus roseus CrPR-10a protein. Here, we present the evidence of a significative increase of endogenous cytokinin contents in leaves of transgenic Tobacco plants over-expressing the CrPR-10a protein. [less ▲]

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See detailMesures agri-environnementales et biodiversité : effet des tournières enherbées sur les populations de syrphes en grandes cultures
Francis, Frédéric ULg; Devallée, Gilles; Terwagne, Sébastien et al

in 1. Annales de la 2ème Conférence Internationale sur les moyens alternatifs de lutte contre les organismes nuisibles aux végétaux (2002)

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See detailThe antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular endothelial growth factor expression in tumor cells
Hajitou, Amin; Grignet, Christine ULg; Devy, L. et al

in FASEB Journal (2002), 16

Endostatin and angiostatin are known as tumor-derived angiogenesis inhibitors, but their mechanisms of action are not yet completely defined. We report here that endostatin and angiostatin, delivered by ... [more ▼]

Endostatin and angiostatin are known as tumor-derived angiogenesis inhibitors, but their mechanisms of action are not yet completely defined. We report here that endostatin and angiostatin, delivered by adenoviral vectors, reduced in vitro the neovessel formation in the mouse aortic ring assay by 85 and 40%, respectively. We also demonstrated in vivo that both endostatin and angiostatin inhibited local invasion and tumor vascularization of transplanted murine malignant keratinocytes, and reduced by 50 and 90% the development of highly vascularized murine mammary tumors. This inhibition of tumor growth was associated with a reduction of tumor vascularization. Expression analysis of vascular endothelial growth factor (VEGF) carried out in the mouse aortic ring model revealed a 3- to 10-fold down-regulation of VEGF mRNA expression in endostatin-treated rings. A similar down-regulation of VEGF expression at both mRNA and protein levels was also observed in the two in vivo cancer models after treatment with each angiogenesis inhibitor. This suggests that endostatin and angiostatin effects may be mediated, at least in part, by their ability to down-regulate VEGF expression within the tumor. This work provides evidence that endostatin and angiostatin act on tumor cells themselves. [less ▲]

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See detailVers un nouveau Droixhe
Frankignoulle, Pierre ULg; Stevens, Barbara

in Cahiers de l'Urbanisme (Les) (2002), 39

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See detailNonmyeloablative allogeneic hematopoietic stem cell transplantation.
Baron, Frédéric ULg; Beguin, Yves ULg

in Journal of Hematotherapy & Stem Cell Research (2002), 11(2), 243-63

Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective treatment for selected hematological malignancies. Its curative potential is largely mediated by an immune-mediated ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective treatment for selected hematological malignancies. Its curative potential is largely mediated by an immune-mediated destruction of malignant cells by donor lymphocytes termed graft-versus-leukemia (GVL) effect. However, because of its toxicity, conventional allogeneic HSCT is restricted to younger and fitter patients. These observations led several groups to set up new (less toxic) transplant protocols (nonmyeloablative stem cell transplantation or NMSCT) based on a two-step approach: first, the use of immunosuppressive (but nonmyeloablative) preparative regimens providing sufficient immunosuppression to achieve engraftment of allogeneic hematopoietic stem cells and, in a second step, destruction of malignant cells by the GVL effect. Preliminary results showed that NMSCT were feasible with a relatively low transplant-related mortality (TRM), even in patients older than 65 years. In addition, strong antitumor responses were observed in several hematological malignancies as well as in some patients with renal cell carcinoma. After discussing the mechanisms and efficacy of the GVL effect as well as the rationale for NMSCT strategies, this article reviews the first results of ongoing clinical trials. Innovative modalities that may permit amplification of the GVL effect while minimizing the risk of GVHD are discussed. Because the benefits of NMSCT over alternative forms of treatment remain to be demonstrated, this strategy should be restricted to patients included in clinical trials. [less ▲]

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