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See detailThe antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular endothelial growth factor expression in tumor cells
Hajitou, Amin; Grignet, Christine ULg; Devy, L. et al

in FASEB Journal (2002), 16

Endostatin and angiostatin are known as tumor-derived angiogenesis inhibitors, but their mechanisms of action are not yet completely defined. We report here that endostatin and angiostatin, delivered by ... [more ▼]

Endostatin and angiostatin are known as tumor-derived angiogenesis inhibitors, but their mechanisms of action are not yet completely defined. We report here that endostatin and angiostatin, delivered by adenoviral vectors, reduced in vitro the neovessel formation in the mouse aortic ring assay by 85 and 40%, respectively. We also demonstrated in vivo that both endostatin and angiostatin inhibited local invasion and tumor vascularization of transplanted murine malignant keratinocytes, and reduced by 50 and 90% the development of highly vascularized murine mammary tumors. This inhibition of tumor growth was associated with a reduction of tumor vascularization. Expression analysis of vascular endothelial growth factor (VEGF) carried out in the mouse aortic ring model revealed a 3- to 10-fold down-regulation of VEGF mRNA expression in endostatin-treated rings. A similar down-regulation of VEGF expression at both mRNA and protein levels was also observed in the two in vivo cancer models after treatment with each angiogenesis inhibitor. This suggests that endostatin and angiostatin effects may be mediated, at least in part, by their ability to down-regulate VEGF expression within the tumor. This work provides evidence that endostatin and angiostatin act on tumor cells themselves. [less ▲]

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See detailL'articulation entre trajectoires professionnelles et familiales féminines
Gavray, Claire ULg

in SOPHIA (Ed.) Etudes féministes en Belgique (2002)

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See detailOn Deriving a Hybrid Model for Carbohydrate Uptake in Escherichia Coli
Bullinger, Eric ULg; Sauter, T.; Allgöwer, F. et al

in Proc. 15th IFAC World Congress (2002)

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See detailNonlinear thin shell finite element for steel and concrete structures subjected to fire: theoretical development
Talamona, Didier; Franssen, Jean-Marc ULg

in Journal of Applied Fire Science (2002), 11(4), 291-310

This article describes the features of a quadrilateral thin shell element, based on Marguerre's theory that has ben implemented in the finite element program SAFIR (from the University of Liege.) The ... [more ▼]

This article describes the features of a quadrilateral thin shell element, based on Marguerre's theory that has ben implemented in the finite element program SAFIR (from the University of Liege.) The element has four nodes (one at each corner) and each node has six degrees of freedom, i.e., three translations and three rotations (the sixth degree of freedom is a true one, which can be assimilated to the in-plane rotation.) This article presents some theoretical developments regarding the element formulation. The algorithm strategies for isotropic material (steel for example) and non-isotropic material 'concrete) and their modifications for elevated temperatures are described. Two verifications examples are presented (the patch test and Lee's frame at elevated temperatures). [less ▲]

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See detailComment etablir le bilan de fin de traitement des patients atteints de lymphomes non-hodgkiniens (LNH) de malignite intermediaire ou elevee?
Warland, V.; Jerusalem, Guy ULg; Hustinx, Roland ULg et al

in Revue Médicale de Liège (2002), 57(12), 779-84

Incomplete regression of a lymphomatous mass after chemotherapy and/or radiotherapy constitutes a major problem in the treatment of lymphoma. In patients with persisting tumor, it could be reasonable to ... [more ▼]

Incomplete regression of a lymphomatous mass after chemotherapy and/or radiotherapy constitutes a major problem in the treatment of lymphoma. In patients with persisting tumor, it could be reasonable to use salvage therapy and possibly hematopoietic stem cell transplantation at the time of minimal disease rather than at the time of clinically overt relapse. The authors reviewed the most appropriate imaging techniques for the assessment of response to treatment. The limitations of CT and MRI for predicting the nature of residual masses are well known. 67Ga scintigraphy has become a standard procedure for the posttreatment evaluation of patients with lymphoma, but it appears that 18F-FDG PET may be a more effective method. Personal experience in the field of PET scan is reported. Although PET should be considered the noninvasive imaging modality of choice, a histological confirmation of residual disease is always necessary before starting salvage therapy. 18F-fluorodeoxyglucose is not a tumor specific radiotracer. [less ▲]

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See detailExercise stress echocardiography in healthy horses
Amory, Hélène ULg; Brihoum, M; Debrue, M et al

in Proceedings of the 41st Annual Congress of the British Equine Veterinary Association (BEVA) (2002)

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See detailLes transports en commun ne sont plus très sûrs : un autre regard sur la sécurité
Jacquemain, Marc ULg

in Politique : Revue de Débats (2002), 27

L'article utilise conjointement des exemples vécus et une enquête pour montrer, à partir du cas des transports en commun, à quel point la notion d'insécurité peut se construire socialement : un même ... [more ▼]

L'article utilise conjointement des exemples vécus et une enquête pour montrer, à partir du cas des transports en commun, à quel point la notion d'insécurité peut se construire socialement : un même contexte apparaîtra ainsi comme sécurisant ou insécurisant en fonction des interprétations et réactions des acteurs. L'article conclut en se demandant si une réponse ostentatoire mais symbolique à la possibilité d'événements insécurisants ne produit finalement pas plus d'insécurité encore. Ce qui demanderait un "changement de logiciel" dans certaines politiques publiques destinées à lutter contre l'insécurité. [less ▲]

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See detailLe prologue en blanc du Lancelot en prose
Combes, Annie ULg

in Baumgartner, Emmanuèle; Harf-Lancner, Laurence (Eds.) Seuils de l'œuvre dans le texte médiéval (2002)

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See detailComparant mais pas fondateur
Caprasse, Olivier ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2002)

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See detailLa gestion de l'agressivité dans le cadre des relations familiales
Naziri, Despina ULg

Conference given outside the academic context (2002)

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See detailSevere Growth hormone deficiency in non diabetic patients with corticotroph microadenomas : effects of pituitary surgery and implications for GH replacement
Valdes Socin, Hernan Gonzalo ULg; Laret, V.; de Fays, C. et al

in 10th Meeting of the European Neuroendocrine Association - Abstract book (2002)

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See detailMass transfer by free and forced convection from single spherical liquid drops
Waheed, M Adekojo; Henschke, Martin; Pfennig, Andreas ULg

in International Journal of Heat & Mass Transfer (2002), 45(22), 4507-4514

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See detailOude modernen. Thomas Vaessens over Nijhoff en Van Ostaijen
Spinoy, Erik ULg

in Tijdschrift voor Nederlandse Taal- en Letterkunde (2002), 118(3), 241-254

This article is a critical response to Thomas Vaessens' book Circus Dubio en Schroom

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See detailEffect of three resuscitation procedures on respiratory and metabolic adaptation to extra uterine life in newborn calves
Uystepruyst, Christophe; Coghe, Joost; Dorts, Thierry et al

in Veterinary Journal (2002), 163(1), 30-44

The purpose of this study was to evaluate the effects of three resuscitation procedures on respiratory and metabolic adaptation to extra-uterine life during the first 24 h after birth in healthy newborn ... [more ▼]

The purpose of this study was to evaluate the effects of three resuscitation procedures on respiratory and metabolic adaptation to extra-uterine life during the first 24 h after birth in healthy newborn calves. Twenty-four newborn calves were randomly grouped into four categories: six calves did not receive any specific resuscitation procedure and were considered as controls (C); six received pharyngeal and nasal suctioning immediately after birth by use of a hand-powered vacuum pump (SUC); six received five litres of cold water poured over their heads immediately after birth (CW) and six were housed in a calf pen with an infrared radiant heater for 24 h after birth (IR). Calves were examined at birth, 5, 15, 30, 45 and 60 min, 2, 3, 6, 12 and 24 h after birth and the following measurements were recorded: physical and clinical examination, arterial blood gas analysis, pulmonary function tests using the oesophageal balloon catheter technique, arterial and venous blood acid-base balance analysis, jugular venous blood sampling for determination of metabolic, haematological and passive immune transfer variables. SUC was accompanied by improved pulmonary function efficiency and by a less pronounced decrease in body temperature. The "head shaking movement" and the subsequent temporary increase in total pulmonary resistance as well as the greater lactic acidosis due to CW were accompanied by more efficient, but statistically non-significant, pulmonary gas exchanges. IR allowed maintenance of higher body temperature without requiring increased catabolism of energetic stores. IR also caused a change in breathing pattern which contributed to better distribution of the ventilation and to slightly improved gas exchange. The results indicate that use of SUC, CW and IR modified respiratory and metabolic adaptation during the first 24 h after birth without side-effects. These resuscitation procedures should be recommended for their specific indication, i.e. cleansing of fetal fluid from upper airways, hypothermal stimulation of breathing and prevention of heat losses. [less ▲]

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See detailRemarques sur le vocabulaire grec de la traduction
Rochette, Bruno ULg

in Revue Belge de Philologie et d'Histoire (2002), 80

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See detailLa décolonisation de l'Afrique
Kabamba, Bob ULg

Learning material (2002)

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See detailDe la pluridisciplinarité à l'interdisciplinarité. Réflexions critiques sur la formation des enseignants en sciences sociales
Guillaume, Jean-François ULg; Barras, Dominique; Xhonneux, Michel ULg

in Puzzle (2002), 11

Réflexion sur le dispositif de formation des enseignants en sciences sociales, à l'Université de Liège, et sur les conditions requises pour une approche "interdisciplinaire".

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See detailPost-mortem findings and causes of death of harbour porpoises (Phocoena phocoena) stranded from 1990 to 2000 along the coastlines of Belgium and northern France
Jauniaux, Thierry ULg; Petitjean, D.; Brenez, C. et al

in Journal of Comparative Pathology (2002), 126(4), 243-253

Between the,ears 1990 and 2000, an attempt was made to determine the causes of death of 55 harbour porpoises stranded along the Belgian and northern French coasts. From 1990 to 1996, only five carcasses ... [more ▼]

Between the,ears 1990 and 2000, an attempt was made to determine the causes of death of 55 harbour porpoises stranded along the Belgian and northern French coasts. From 1990 to 1996, only five carcasses were collected as against seven in 1997, eight in 1998, 27 in 1999 and eight in 2000. The sex ratio was normal and most of the animals were juvenile. The most common findings were emaciation, severe parasitosis and pneumonia. A few cases of fishing net entanglement were observed. The main microscopical lesions were acute pneumonia, massive lung oedema, enteritis, hepatitis and gastritis. Encephalitis was observed in six cases. No evidence of morbillivirus infection was detected. Pneumonia was associated with bacteria or parasites, or both. The causes of death and the lesions were similar to those previously reported in other countries bordering the North Sea. The cause of the increased numbers of carcasses in 1999 was unclear but did not include viral epizootics or net entanglement. A temporary increase in the porpoise populatiou in the southern North Sea may have been responsible. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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