References of "2002"
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See detailRelevance of molecular biology to Psychopharmacology
Bettendorff, Lucien ULg

Conference (2002)

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See detailShort- and long-term advantages of an alternative ontogenetic pathway
Denoël, Mathieu ULg; Hervant, F.; Schabetsberger, R. et al

in Biological Journal of the Linnean Society (2002), 77(1), 105-112

We documented hypotheses on the evolution of developmental heterochronies by estimating short- and long-term advantages of alternative morphs. In this respect, we compared food energy intakes and body ... [more ▼]

We documented hypotheses on the evolution of developmental heterochronies by estimating short- and long-term advantages of alternative morphs. In this respect, we compared food energy intakes and body condition between paedomorphic and metamorphic Alpine newts (Triturus alpestris, Caudata, Amphibia) in four populations. Because we found a strong correlation between fat reserves and body condition, we used this last parameter as an indicator of long-term gains. In all studied sites, paedomorphic females showed higher body condition than metamorphic ones. Paedomorphic males were also at advantage in two populations. Paedomorphs exhibited higher energy intakes than metamorphs in two populations and similar gains in two others. Our results support unifying theories that predict the occurrence of facultative paedomorphosis in varied habitats as paedomorphs exhibited better energy balance than metamorphs. This work shows the need for considering integrative parameters such as body condition in the comparative study of performances when studying developmental heterochronies. (C) 2002 The Linnean Society of London, Biological Journal of the Linnean Society, 2002, 77, 105-112. [less ▲]

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See detailMerleau-Ponty : philosophie et peinture (perception et participation)
Steinmetz, Rudy ULg

Conference given outside the academic context (2002)

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See detailUse of Anesthesia Simulator
Pendeville, Philippe; Mayne, Alain; LARBUISSON, Robert ULg et al

in Benelux quaterly journal on automatic control (2002), 43(2), 17-19

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See detailIsolement et caractérisation de l'ostéocalcine équine
Carstanjen, Bianca; Wattiez, R.; Amory, Hélène ULg et al

in Annales de Médecine Vétérinaire (2002), 146

Equine bone gamma-carboxyglutamic acid containing protein - also called osteocalcin - has been isolated for the first time till homogeneity. After acid demineralisation and acid extraction, the ... [more ▼]

Equine bone gamma-carboxyglutamic acid containing protein - also called osteocalcin - has been isolated for the first time till homogeneity. After acid demineralisation and acid extraction, the purification procedure was based on reverse phase chromatography, gel filtration and ion exchange chromatography. The amino acid sequence of the primary structure has been determined to be YLDHWLGA(HYP) APYPDPL(GLA)PRR(GLA)VC (GLA)LNPDCDELADHIGF-AYRRFYGPV. The protein has a calculated molecular weight of 5,732 kDa and a calculated isoelectric point of 4,45. It contains 49 amino acids, from which 3 are gamma-carboxyglutamic acid residues at position 17, 21 and 24 and has a fully hydroxylated proline in position nine and cysteine in position 23 and 29. Equine osteocalcin shows a strong homology with bovine (98%), ovine (96%) and human (94%) osteocalcin [less ▲]

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See detailRecension de l'ouvrage collectif, "L'art et l'hybride"
Steinmetz, Rudy ULg

in Cahiers Internationaux de Symbolisme (2002)

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See detailSelf-esteem, social adjustment and suicidality in affective disorders
Daskalopoulou, E; Dikeos, D; Papadimitriou, G et al

in European Psychiatry (2002), 17

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See detailPhénomènes karstiques fossiles et actuels au sein des formations métamorphiques silico-alumineuses de la nappe pan-africaine de Yaoundé (Sud-Cameroun)
Vicat, Jean-Paul; Mvondoc, Henri; Willems, Luc ULg et al

in Comptes Rendus de l'Académie des Sciences. Série II, Mécanique, Physique, Chimie, Sciences de l'Univers, Sciences de la Terre (2002), 334

Fossil and present-time karstic phenomena in silico-aluminous metamorphic formations of the Pan-African nappe of Yaoundé (South-Cameroon). Numerous karstic features have been recognised in the non ... [more ▼]

Fossil and present-time karstic phenomena in silico-aluminous metamorphic formations of the Pan-African nappe of Yaoundé (South-Cameroon). Numerous karstic features have been recognised in the non-carbonaceous micaschists and gneisses of the Yaoundé Pan-African nappe, south of Cameroon. It is shown that their formation was controlled by the structural features of the rocks. The wells and the pipes in the bedrock outcrops point out a current karstification process, resulting from the plagioclase dissolution by the acid rain waters. Hill wall alveoli and caves, of pre-Miocene age, are exhumed features that were done by dissolution in the aquiferous underground. [less ▲]

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See detailNew perspectives n the medical management of osteoarthritis
Reginster, Jean-Yves ULg

in Osteoarthritis and Cartilage (2002), 10(SA), 18-19

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See detailSynthesis and characterization of nanostructured mesoporous zirconia catalyst supports using non-ionic surfactants as templating agents
Blin, J. L.; Gigot, L.; Léonard, Alexandre ULg et al

in Studies in Surface Science and Catalysis (2002), 143

The formation of nanostructured porous zirconia catalyst supports using non-ionic surfactants as templating agents has been studied in order to optimize the synthesis conditions without addition of ... [more ▼]

The formation of nanostructured porous zirconia catalyst supports using non-ionic surfactants as templating agents has been studied in order to optimize the synthesis conditions without addition of structure stabilizing agents such as sulfate or phosphate anions. The effect of the quantity of added zirconium source with respect to the surfactant concentration in solution has been studied. We also examined the role played by the surfactant during the synthesis. Further investigations have shown that the pore diameters could be increased towards the mesoporous domain if heating time and temperature are raised. The present work reveals that the control of the balance between the precipitation rate of zirconia and the interaction of zirconium source will be fatal in the formation of nanostructured porous zirconia. [less ▲]

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See detailThe genetic absence epilepsy rat from Strasbourg (GAERS), a rat model of absence epilepsy: Computer modeling and differential gene expression
Lakaye, Bernard ULg; Thomas, E.; Minet, Arlette ULg et al

in Epilepsia (2002), 43(Suppl. 5), 123-129

Purpose: We present results obtained by computer modeling of the thalamic network and differential gene expression analysis in a rat strain with absence epilepsy, the genetic absence epilepsy rat from ... [more ▼]

Purpose: We present results obtained by computer modeling of the thalamic network and differential gene expression analysis in a rat strain with absence epilepsy, the genetic absence epilepsy rat from Strasbourg (GAERS). Methods: (a) Computer modeling used equations from the Hodgking-Huxley model with a circuit of 13 reticular thalamic (nRt) and 39 thalamocortical (TC) neurons; (b) gene-expression analysis using differential mRNA display (DD), in situ hybridization, Northern blotting, and competitive reverse transcriptase-polymerase chain reaction (RT-PCR). Results: (a) Computer modeling showed an increased network synchrony in the thalamic circuit as the value of conductance of low-voltage activated calcium channel (LVACC) is increased. (b) Using differential mRNA display, a 40% upregulation of the H-ferritin mRNA in the hippocampus was demonstrated. Looking for some candidate genes of the VACC family, no difference was found in the alpha1G mRNA expression between GAERS and control animals, whereas a decreased expression of the alpha1E subunit was observed in the cerebellum and the brainstem of the GAERS. This phenomenon was not observed in young animals when the epileptic phenotype is not expressed. Conclusions: The use of computer modeling appeared to be an efficient way to evaluate the impacts of electrophysiologic findings in vivo from single cells on an entire circuit. No clear single gene defect was revealed so far in GAERS. More information could arise from linkage analysis. However, some brain structures like hippocampus or cerebellum classically not known to be involved in the production of absence spike-and-wave discharges could in fact participate in the development of this phenotype. [less ▲]

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See detailSécurité alimentaire des produits du terroir : aide, conseil, expertise.
Sindic, Marianne ULg

Article for general public (2002)

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See detailAssociation of a new c-Cbl related protein with the very first stages of apoptosis induction
Corsois, L.; Quatannens, B.; Dumont, P. et al

in Cancer Detection and Prevention (2002), 26(2), 93-104

This study investigates the involvement of the c-cbl proto-oncogene during the first stages of the apoptotic process. We have already shown that a c-Cbl aptotosis-related protein of 90 kDa (CARP 90) is ... [more ▼]

This study investigates the involvement of the c-cbl proto-oncogene during the first stages of the apoptotic process. We have already shown that a c-Cbl aptotosis-related protein of 90 kDa (CARP 90) is detected very rapidly in the cytoplasm as well as in the nucleus of murine thymocytes after hydrocortisone (HC) treatment. We report here that this protein appeared as well after in vivo treatment of mice by gamma-irradiation or injection of anti-CD3 monoclonal antibody, two potent thymic apoptosis inductors, providing a close relationship between the occurrence of apoptosis and the appearance of CARP 90. We showed that CARP 90 and p120(cbl) share numerous epitopes strikingly suggesting that CARP 90 is coded by c-cbl. In addition, KO mice do not sustain CARP 90 appearance. We finally showed that CARP 90 contains N- and C-terminal end epitopes of p120(cbl) which suggests that CARP 90 is an alternative spliced form of c-cbl. This protein was also observed under gamma-irradiation in tissues of different origin, which enlarges the physiological significance of this phenomenon. The very rapid CARP 90 appearance under apoptotic conditions in the nucleus of cells originating in different tissues makes this protein if not a possible new actor of the apoptotic process, at least an interesting marker of this process. (C) 2002 International Society for Preventive Oncology. Published by Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailApproches pharmacologiques de prévention du diabète de type 2.
SCHEEN, André ULg; PAQUOT, Nicolas ULg; LETIEXHE, Michel ULg et al

in Médecine et Hygiène (2002), 60

L’augmentation rapide de la prévalence du diabète de type 2 impose la mise en place de stratégies de prévention. Outre les mesures hygiéno-diététiques, essentielles, diverses approches pharmacologiques ... [more ▼]

L’augmentation rapide de la prévalence du diabète de type 2 impose la mise en place de stratégies de prévention. Outre les mesures hygiéno-diététiques, essentielles, diverses approches pharmacologiques ont apporté récemment la preuve d’une certaine efficacité chez les sujets à risque de par la présence d’un excès pondéral et/ou d’une diminution de la tolérance au glucose. C’est le cas de plusieurs antidiabétiques oraux comme la metformine, l’acarbose ou encore la troglitazone. C’est également le cas de médicaments anti-obésité comme l’orlistat et, peut-être aussi, la sibutramine. L’inhibition du système rénine-angiotensine par un inhibiteur de l’enzyme de conversion ou par un antagoniste sélectif des récepteurs AT1 peut aussi, outre protéger contre les complications cardiovasculaires, prévenir l’apparition d’un diabète de type 2. Enfin, le rôle des médicaments hypolipidémiants reste controversé. De nouvelles études prospectives sont en cours pour confirmer ces résultats. [less ▲]

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See detailSeparation, identification and quantitation of ceramides in human cancer cells by liquid chromatography–electrospray ionization tandem mass spectrometry
Fillet, Marianne ULg; Van Heugen, Jean-Claude ULg; Servais, Anne-Catherine ULg et al

in Journal of Chromatography. A (2002), 949

Ceramides are important intracellular second messengers that play a role in the regulation of cell growth, differentiation and programmed cell death. Qualitative and quantitative analysis of these second ... [more ▼]

Ceramides are important intracellular second messengers that play a role in the regulation of cell growth, differentiation and programmed cell death. Qualitative and quantitative analysis of these second messengers requires sensitive and specific analytical methods to detect endogenous levels of individual ceramide species and to differentiate between them. Nine synthetic ceramides were separated by liquid chromatography coupled to tandem mass spectrometry on a C bonded silica 18 column. The lipids were eluted in gradient elution mode using a mixture of water, acetonitrile and 2-propanol as mobile phase. They were detected by reaction monitoring performed on positive ion electrospray generated ions. Collision-induced fragmentations conducted on ceramides produced a well characteristic product ion at m/z 264, making multiple reaction monitoring (MRM) well suited for various ceramides quantitative measurements. After optimization of the extraction step, the proposed methodology was able to identify and quantify different ceramide species issued from human cancer cells. The method could be validated for C , C and C ceramides, quantified at the nanogram level. The validation exhibits good 16 18 20 results with respect to linearity, accuracy and precision. [less ▲]

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See detailChanging pattern of bacterial susceptibility to antibiotics in hematopoietic stem cell transplant recipients.
Frere, Pascale ULg; Hermanne, J.-P.; Debouge, M.-H. et al

in Bone Marrow Transplantation (2002), 29(7), 589-94

Adequate infection prophylaxis and empirical antibiotic therapy are of critical importance after hematopoietic stem cell transplantation (HSCT). We examined the evolution of bacterial susceptibility to ... [more ▼]

Adequate infection prophylaxis and empirical antibiotic therapy are of critical importance after hematopoietic stem cell transplantation (HSCT). We examined the evolution of bacterial susceptibility to antibiotics in 492 patients (198 allografts and 294 autografts) transplanted between 1982 and 1999 and evaluated whether ciprofloxacin prophylaxis and an empirical antibiotic regimen (glycopeptide + third-generation cephalosporin) were still valid. We collected all susceptibility tests performed during the initial hospitalization on blood cultures as well as routine surveillance cultures and analyzed susceptibility to ciprofloxacin and to major antibiotics used in our unit. Gram-positive cocci rapidly became resistant to ciprofloxacin (susceptibility around 70% in 1990 to less than 20% in 1998) but sensitivity to glycopeptides remained unaltered. There was a rapid decline in the number of patients colonized with Gram-negative bacilli in the early years of ciprofloxacin prophylaxis. However, susceptibility to ciprofloxacin fell sharply from around 90% in 1990 to around 30% in 1999. In parallel, susceptibility to ceftazidime also decreased to less than 80% in recent years. Piperacillin (+/- tazobactam) did not show any variation over time and its efficacy remained too low (about 60%). Imipenem as well as recently introduced cefepim and meropenem showed stable and excellent profiles (>90% susceptibility). In conclusion: (1) quinolone prophylaxis has now lost most of its value; (2) the choice of a third-generation cephalosporin for empirical antibiotic therapy may no longer be the best because of the emergence of Gram-negative strains resistant to beta-lactamases, such as Enterobacter sp. More appropriate regimens of empirical antibiotic therapy in HSCT recipients may be based on the use of a carbapenem or fourth-generation cephalosporin. [less ▲]

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See detailIncreased binding and defective migration across fibronectin of cycling hematopoietic progenitor cells.
Giet, Olivier ULg; Van Bockstaele, Dirk R; Di Stefano, Ivano et al

in Blood (2002), 99(6), 2023-31

Engraftment of hematopoietic progenitor cells has been shown to decrease during cell cycle transit. We studied cell cycle-associated changes in adhesion and migration of mitotically activated cord blood ... [more ▼]

Engraftment of hematopoietic progenitor cells has been shown to decrease during cell cycle transit. We studied cell cycle-associated changes in adhesion and migration of mitotically activated cord blood CD34+ cells. Migration toward medium conditioned by the stromal-derived factor-1-producing cell line MS-5 was studied in bovine serum albumin- and fibronectin (Fn)-coated transwells. Migration was reduced in cycling CD34+ cells and long-term culture-initiating cells (LTC-ICs) compared with their noncycling counterparts across Fn but not across bovine serum albumin. Conversely, Fn binding was higher in cycling CD34+ cells and LTC-ICs compared with noncycling progenitor cells, while adhesion of both subsets to bovine serum albumin was undetectable. The contribution of alpha4 and alpha5 integrins in mediating adhesion and migration of activated CD34+ cells onto Fn was analyzed by neutralization experiments. While alpha4-mediated Fn binding decreased during G(2)/M, alpha5 integrin-mediated adhesion increased during transit from G(0)/G(1) to S and G(2)/M phases. As for migration, the contribution of alpha4 integrin was similar in all phases, whereas alpha5-directed migration was lower in G(2)/M compared with G(0)/G(1) and S phases. Defective migration of cycling CD34+ cells was not due to differences in alpha5 integrin expression. In conclusion, chemotaxis across Fn is less efficient in cycling progenitor cells in correlation with an increased Fn binding capacity. In addition, alpha4 and alpha5 integrin functions are independently modulated during cell cycle transit. [less ▲]

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