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See detailFast F-18 FDG synthesis by alkaline hydrolysis on a low polarity solid phase supports
Lemaire, Christian ULg; Damhaut, P.; Lauricella, Benjamino ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2002), 45(5), 435-447

The synthesis of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) has been simplified by the use of a tC18 Sep Pak cartridge to effect purification and hydrolysis of the tetraacetylated [18F]fluoro-glucose ... [more ▼]

The synthesis of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) has been simplified by the use of a tC18 Sep Pak cartridge to effect purification and hydrolysis of the tetraacetylated [18F]fluoro-glucose compound ([18F]TAG). After radiolabelling, this derivative was trapped on a solid phase extraction (SPE) cartridge and the residual reaction solvent (CH3CN), reagents (K222, K2CO3,) and by-products removed by washing the support with water. After this cleaning step, the acetyl groups were cleaved on the same tC18 column using 2N sodium hydroxide. This fast reaction proceeded near quantitatively (>98%) at room temperature in less than 2 min. The [18F]FDG was then recovered with a small amount of water, neutralized with a slight excess of 2N hydrochloric acid, buffered for pH with a citrate solution and finally purified on a neutral alumina oxide and a second tC18 column. After filtration, the radiochemical yield of this [18F]FDG isotonic solution after more than 100 production runs was found to be very reliable and reproducible (70±6% decay corrected). The synthesis time was about 22 min. Quality controls showed that the radiochemical purity was higher than 98% and in any case no [18F]FDM was detected. Only traces of 2-chloro-2-deoxy-glucose (ClDG) were found in the final sample (64±9 g/ batch of 16 ml). [18F]FDG specific activity averaged between 1 and 20 Ci/µmol (EOS). No evaporation and use of ion retardation resin (AG11A8) are required. Moreover, this new approach is suitable for complete remote operation using available single use medical components. Copyright © 2002 John Wiley [less ▲]

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See detailProduction de viande: la femelle de réforme Blanc-Bleu Belge cularde
Cabaraux, Jean-François ULg; Dufrasne, Isabelle ULg; Van Eenaeme, Christian ULg et al

Book published by Ministère des Classes moyennes et de l'Agriculture, Service Développement Production animale (2002)

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See detailLa clé des champs au risque de mettre la clé sous la porte
Graas, Christelle; Noel, Véronique; argento, gino et al

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2002), 5

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See detailGéomorphologie du milieu littoral et aménagement
Ozer, André ULg; Ozer, Pierre ULg

in Fierro, Giuliano (Ed.) MED PICTURE : Mediterranean Project for the Improvement of Cooperation in Training between Universities, Regions and Enterprises (2002)

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See detailOxidative stress status in top soccer players
Pincemail, Joël ULg; Bonjean, K.; Cayeux, C. et al

in Free Radical Biology & Medicine (2002), 33(Suppl. 1), 249-249

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See detailLa mesure de la pression artérielle : écueils et chausse-trapes
Rorive, Georges ULg; Dubois, Bernard ULg; Saint-Remy, Annie ULg

in Revue Médicale de Liège (2002), 57(5), 250-252

La mesure de la pression artérielle est probablement l'acte médical le plus souvent réalisé et certainement un des moins fiables. L'introduction de la mesure ambulatoire de la pression artérielle a permis ... [more ▼]

La mesure de la pression artérielle est probablement l'acte médical le plus souvent réalisé et certainement un des moins fiables. L'introduction de la mesure ambulatoire de la pression artérielle a permis d'identifier l'importance de l'effet consultatio et, par là, de définir l'hypertension de "la blouse blanche". Celle-ci se définit comme une pression artérielle pathologique à la consultation et strictement normale en dehors. Si on la définit de cette manière, cette pathologie ne s'accompagne pas d'une augmentation de la fréqunce des affections cardiovasculaires. Chez un tiers des patients, cependant, elle évolue vers des formes plus sévères de l'hypertension. [less ▲]

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See detailThe genetic absence epilepsy rat from Strasbourg (GAERS), a rat model of absence epilepsy: Computer modeling and differential gene expression
Lakaye, Bernard ULg; Thomas, E.; Minet, Arlette ULg et al

in Epilepsia (2002), 43(Suppl. 5), 123-129

Purpose: We present results obtained by computer modeling of the thalamic network and differential gene expression analysis in a rat strain with absence epilepsy, the genetic absence epilepsy rat from ... [more ▼]

Purpose: We present results obtained by computer modeling of the thalamic network and differential gene expression analysis in a rat strain with absence epilepsy, the genetic absence epilepsy rat from Strasbourg (GAERS). Methods: (a) Computer modeling used equations from the Hodgking-Huxley model with a circuit of 13 reticular thalamic (nRt) and 39 thalamocortical (TC) neurons; (b) gene-expression analysis using differential mRNA display (DD), in situ hybridization, Northern blotting, and competitive reverse transcriptase-polymerase chain reaction (RT-PCR). Results: (a) Computer modeling showed an increased network synchrony in the thalamic circuit as the value of conductance of low-voltage activated calcium channel (LVACC) is increased. (b) Using differential mRNA display, a 40% upregulation of the H-ferritin mRNA in the hippocampus was demonstrated. Looking for some candidate genes of the VACC family, no difference was found in the alpha1G mRNA expression between GAERS and control animals, whereas a decreased expression of the alpha1E subunit was observed in the cerebellum and the brainstem of the GAERS. This phenomenon was not observed in young animals when the epileptic phenotype is not expressed. Conclusions: The use of computer modeling appeared to be an efficient way to evaluate the impacts of electrophysiologic findings in vivo from single cells on an entire circuit. No clear single gene defect was revealed so far in GAERS. More information could arise from linkage analysis. However, some brain structures like hippocampus or cerebellum classically not known to be involved in the production of absence spike-and-wave discharges could in fact participate in the development of this phenotype. [less ▲]

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See detailA. Gacek: The Arabic manuscript tradition: A glossary of technical terms and bibliography
Bauden, Frédéric ULg

in Journal of the American Oriental Society (2002), 122(3), 658-659

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See detailRôle du gène cap-like dans la répression catabolique chez Streptomyces
Derouaux, Adeline ULg; Giannotta, Fabrizio; Rigali, Sébastien ULg et al

Conference (2002)

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See detailCommented bibliography on Belgium
Halleux, Jean-Marie ULg

in Dubois-Taine, G. (Ed.) Outskirts of European cities – state of the art report (2002)

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See detailLa suppression de la communauté de La Ramée en 1796 et la vente de l'abbaye
Henneau, Marie-Elisabeth ULg

in Coomans, Thomas (Ed.) La Ramée, abbaye cistercienne en Brabant wallon (2002)

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See detailWeetjes 2 : grammaticale terminologie
Vromans, Joseph ULg

Software (2002)

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See detailComment etablir le bilan de fin de traitement des patients atteints de lymphomes non-hodgkiniens (LNH) de malignite intermediaire ou elevee?
Warland, V.; Jerusalem, Guy ULg; Hustinx, Roland ULg et al

in Revue Médicale de Liège (2002), 57(12), 779-84

Incomplete regression of a lymphomatous mass after chemotherapy and/or radiotherapy constitutes a major problem in the treatment of lymphoma. In patients with persisting tumor, it could be reasonable to ... [more ▼]

Incomplete regression of a lymphomatous mass after chemotherapy and/or radiotherapy constitutes a major problem in the treatment of lymphoma. In patients with persisting tumor, it could be reasonable to use salvage therapy and possibly hematopoietic stem cell transplantation at the time of minimal disease rather than at the time of clinically overt relapse. The authors reviewed the most appropriate imaging techniques for the assessment of response to treatment. The limitations of CT and MRI for predicting the nature of residual masses are well known. 67Ga scintigraphy has become a standard procedure for the posttreatment evaluation of patients with lymphoma, but it appears that 18F-FDG PET may be a more effective method. Personal experience in the field of PET scan is reported. Although PET should be considered the noninvasive imaging modality of choice, a histological confirmation of residual disease is always necessary before starting salvage therapy. 18F-fluorodeoxyglucose is not a tumor specific radiotracer. [less ▲]

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See detail18F-fluoro-L-tyrosine : a potential tracer for whole-body tumor imaging with PET.
HUSTINX, Roland ULg; LEMAIRE, C.; JERUSALEM, Guy ULg et al

in Journal of Nuclear Medicine (The) (2002), 43

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See detailNumerical modeling of hydro-mechanical fracture behavior
Guiducci, Chiara; Pellegrino, Antonio; Radu, Jean-Pol ULg et al

in Pande, G. N.; Pietruszczak, S. (Eds.) Numerical models in Geomechanics (2002)

A numerical approach for modeling coupled hydro-mechanical fracture behavior is proposed. The movement of fluids through rock fractures is important in many engineering areas of practical interest such as ... [more ▼]

A numerical approach for modeling coupled hydro-mechanical fracture behavior is proposed. The movement of fluids through rock fractures is important in many engineering areas of practical interest such as those ones of petroleum and mining engineering. In that context, one of the most investigated and complex subjects is the effect on well productivity due to changes in hydraulic conductivity both on the matrix rock and on its main fractures. It is well known, that these flow characteristics are strongly controlled by fracture apertures. Recent investigations on the distribution of the apertures in natural fractures suggest that the cubic law can, better than the Darcy law, predict the fluid flux through rough walled fractures as long as the appropriate average fracture aperture is used. A finite element code is developed to predict the influence that the stresses variation in the soil has on the distributed hydraulic conductivity field. The proposed model combines the stochastic cubic law with a non-linear deformation function (hyperbolic) that is suggested to describe the stress-closure/opening curves of the joints and that allows to couple together the hydraulic and the mechanic fracture behavior. The relationships used and the validity of the present model are tested through comparison between experimental data and numerical predictions (Bart 2000) in various boundary and loading conditions. Comparison between the Darcy model governing fluid flow equation and linear stress-closure/opening relation has also been performed showing the differences and the better de-scription given by the proposed new model. [less ▲]

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See detailThe multivariate Dale model and genetic associations
Van Steen, Kristel ULg; Molenberghs, G.; Tahri, N.

in American Journal of Human Genetics (2002), 71

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