Identificación de adhesinas F17 y CS31A en Escherichia coli aislados de terneros diarreicos o septicémicos.

Poster (2002, November 12)

European Research 2002

Scientific conference (2002, November 12)

Optical spectroscopy of X-Mega targets - IV. CPD-59 degrees 2636: a new O-type multiple system in the Carina Nebula

in Monthly Notices of the Royal Astronomical Society (2002), 336(4), 1099-1108

High-resolution optical spectroscopy of CPD -59degrees2636, one of the O-type stars in the open cluster Trumpler 16 in the Carina Nebula, reveals this object to be a multiple system displaying triple ... [more ▼]

High-resolution optical spectroscopy of CPD -59degrees2636, one of the O-type stars in the open cluster Trumpler 16 in the Carina Nebula, reveals this object to be a multiple system displaying triple lines which we label as components A, B and C of spectral types O7 V, O8 V and O9 V, respectively. From our radial velocity measurements we find that the components A and B form a close binary with a period of 3.6284 d, and we obtain the first circular radial velocity orbit for this system with semi-amplitudes of 184 and 192 km s(-1), leading to minimum masses of 10.1 and 9.7 M-.. We find that the component C is a single lined binary with a period of 5.034 d and semi-amplitude of 48 km s(-1). We also analyse the X-ray radiation from CPD -59degrees2636, finding neither appreciable overluminosity nor phase-related X-ray flux variations. [less ▲]

Enterohaemorrhagic Escherichia coli (EHEC) isolated from 2 months old Southamerican camelid (Lamea guanacoe) with diarrhoea.

Poster (2002, November 10)

Myoglobinurie atypique: nouveaux cas en Belgique et en France

Conference (2002, November 09)

Les coûts réels de la désurbanisation

Conference given outside the academic context (2002)

New pyridobenzodiazepine derivatives: Modifications of the basic side chain differentially modulate binding to dopamine (D-4.2, D-2L) and serotonin (5-HT2A) receptors

in Journal of Medicinal Chemistry (2002), 45(23), 5136-5149

A series of new pyridobenzodiazepines with variation of the basic side chain were synthesized and evaluated for their binding to D-4.2, D-2L, and 5-HT2A receptors in comparison with clozapine, haloperidol ... [more ▼]

A series of new pyridobenzodiazepines with variation of the basic side chain were synthesized and evaluated for their binding to D-4.2, D-2L, and 5-HT2A receptors in comparison with clozapine, haloperidol, and two parent compounds previously described, 8-chloro-6-(4-methyl-1-piperazinyl)-11H-pyrido[2,3-b][1,4]benzodiazepine (8) and 8-methyl-6-(4-methyl-1-piperazinyl)-11H-pyrido[2,3-b][1,4]benzodiazepine (9). In the piperazine series, replacing the N-methyl group by a N-phenyl moiety (15-17, 30-32) provided a dramatic decrease of affinity for all receptors (K-i > 1000 nM). A N-cyclohexyl group (20, 35) restored some affinity. Compounds with a N-benzyl (18, 33) or N-phenethyl side chain (19, 34) had significant affinities at D-4.2 and 5-HT2A receptors. Homologation of the piperazine nucleus (29, 44) led to a significant decrease of the affinity at all receptors investigated. In the 4-aminopiperidine series, N-methyl derivatives (21, 36) possessed less affinity in comparison with the N-metbylpiperazine analogues (8, 9) while the N-benzyl congeners (22, 37) showed similar affinities. The rigidification of piperidine nucleus as obtained in azabicyclo [3.2.1] octane derivatives (23, 38) involved a slight reduction of the affinity at D-4.2 and 5-HT2A receptors while the affinity at D-2L receptors was dramatically increased. The introduction of N-substituted aminoalkylamines to replace N-methylpiperazine generally led to a significant decrease in the affinity for D-4.2 receptors but some of these molecules (24, 25, 41) presented a significant 5-HT2A binding affinity. The presence of a more flexible side chain induced an increased conformational freedom. Consequently, the preferential position of the distal nitrogen or its basicity in piperazine derivatives was greatly modified. 19 with a high D-4.2 and 5-HT2A affinity (K-i = 40 and 103 nM, respectively) did not induce cataleptic phenomenon in the paw test in rats but significantly reduced the immobility time in Porsolt's test in mice suggesting antidepressant properties. [less ▲]

Comparaison des troponines I et T cardiaques dans les syndromes coronariens aigus

Conference (2002, November 07)

Selective encryption of uncompressed and compressed images

Scientific conference (2002, November 06)

Anesthésie de la femme enceinte. Les risques pour la mère et l'enfant

Conference (2002, November 04)