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See detailPsychomotor retardation, spastic paraplegia, cerebellar ataxia and dyskinesia associated with low 5-methyltetrahydrofolate in cerebrospinal fluid: A novel neurometabolic condition responding to folinic acid substitution
Ramaekers, Vincent ULiege; Häusler, M.; Opladen, T. et al

in Neuropediatrics (2002), 33(6), 301-308

Introduction: Normal brain development and function depend on the active transport of folates across the blood-brain barrier. The folate receptor-1 (FR1) protein is localized at the basolateral surface of ... [more ▼]

Introduction: Normal brain development and function depend on the active transport of folates across the blood-brain barrier. The folate receptor-1 (FR1) protein is localized at the basolateral surface of the choroid plexus, which is characterized by a high binding affinity for circulating 5-methyltetrahydrofolate (5- MTHF). Patients and Methods: We report on the clinical and metabolic findings among five children with normal neurodevelopmental progress during the first four to six months followed by the acquisition of a neurological condition which includes marked irritability, decelerating head growth, psychomotor retardation, cerebellar ataxia, dyskinesias (choreoathetosis, ballism), pyramidal signs in the lower limbs and occasional seizures. After the age of six years the two oldest patients also manifested a central visual disorder. Known disorders have been ruled out by extensive investigations. Cerebrospinal fluid (CSF) analysis included determination of biogenic monoamines, pterins and 5-MTHF. Results: Despite normal folate levels in serum and red blood cells with normal homocysteine, analysis of CSF revealed a decline towards very low values for 5-methyltetrahydrofolate (5-MTHF), which suggested disturbed transport of folates across the blood-brain barrier. Genetic analysis of the FR1 gene revealed normal coding sequences. Oral treatment with doses of the stable compound folinic acid (0.5-1 mg/kg/day Leucovorin®) resulted in clinical amelioration and normalization of 5-MTHF values in CSF. Conclusion: Our findings identified a new condition manifesting after the age of 6 months which was accompanied by low 5-MTHF in cerebrospinal fluid and responded to oral supplements with folinic acid. However, the cause of disturbed folate transfer across the blood-brain barrier remains unknown. [less ▲]

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See detailChemo-mechanical interactions in clay: are the Atterberg limits useful?
Schmitz, R.; Hiligsmann, M.; Schroeder, Christian ULiege et al

in Clays in Natural and Engineered Barriers of Radioactive Waste Confinement - Int. Meeting Reims (2002, December)

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See detailFormulations statiques : électrostatique, électrocinétique, magnétostatique
Dular, Patrick ULiege; Piriou, Francis

in Meunier, Gérard (Ed.) Modèles et formulations en électromagnétisme - Electromagnétisme et éléments finis 2 (2002)

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See detailExploring the effect of action familiarity on SPTs recall performance in Alzheimer's disease
Lekeu, Françoise ULiege; Van der Linden, Martial ULiege; Moonen, Gustave ULiege et al

in Journal of Clinical and Experimental Neuropsychology (2002), 24(8), 1057-1069

This study examined the performance of normal controls (NC) and Alzheimer's disease (AD) patients on free recall, semantic cued recall and object cued recall of both subject-performed tasks (SPTs) and ... [more ▼]

This study examined the performance of normal controls (NC) and Alzheimer's disease (AD) patients on free recall, semantic cued recall and object cued recall of both subject-performed tasks (SPTs) and verbal descriptions of actions, by controlling familiarity of actions associated to objects. The results showed that both groups performed better after SPT encoding than after verbal encoding. in all three types of recall. In addition, this SPT advantage was greater for AD patients than for NC in the object cued recall test, emphasizing AD patients' sensibility to the congruence of cues between encoding and retrieval conditions. Following verbal encoding. NC showed a better recall for less familiar actions than for highly familiar actions, whereas AD patients exhibited the opposite pattern. These results reflect that AD patients did not benefit from a distinctiveness effect at encoding for improving subsequent retrieval of verbal information, probably due to a reduced level of elaboration during encoding. However, there was no effect of action familiarity on recall performance by both groups following SPT encoding. These results suggest that memory for verbal actions and SPTs is governed by different principles. In addition. they demonstrate the robustness of the SPT effect in AD patients, who were able to improve memory performance in the SPT condition not only with highly familiar actions but also with less familiar actions. [less ▲]

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See detailFun stories about Brucella: the "furtive nasty bug".
Letesson, Jean-Jacques; Lestrate, Pascal; Delrue, Rose-May et al

in Veterinary Microbiology (2002), 90(1-4), 317-28

Although Brucella is responsible for one of the major worldwide zoonosis, our understanding of its pathogenesis remains in its infancy. In this paper, we summarize some of the research in progress in our ... [more ▼]

Although Brucella is responsible for one of the major worldwide zoonosis, our understanding of its pathogenesis remains in its infancy. In this paper, we summarize some of the research in progress in our laboratory that we think could contribute to a better understanding of the Brucella molecular virulence mechanisms and their regulation. [less ▲]

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See detailDependence of the morphology development on the kinetics of reactive melt blending of immiscible polymers
Yin, Zhiyui; Koulic, Christian; Pagnoulle, Christophe et al

in Canadian Journal of Chemical Engineering (2002), 80(6), 1044-1050

Poly(methyl methacrylate) (PMMA) containing 50 wt% of anthracene (anth) labeled reactive PMMA chains [thus end-capped by an anhydride (anh) or an isocyanate (NCO)] has been melt blended with polystyrene ... [more ▼]

Poly(methyl methacrylate) (PMMA) containing 50 wt% of anthracene (anth) labeled reactive PMMA chains [thus end-capped by an anhydride (anh) or an isocyanate (NCO)] has been melt blended with polystyrene containing 33 wt% of chains end-capped by an aliphatic amine (PS-NH2) at 180degreesC. Conversion of anth-PMMA-anh and anth-PMMA-NCO into PMMA-b-PS copolymers has been determined by SEC with a UV detector. The interfacial reaction mainly occurs in the initial mixing stage (less than or equal to1.0 min), although at a rate which depends on the reactive groups attached to PMMA. Moreover, this interfacial reaction rate controls how the phase morphology is developed. [less ▲]

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See detailAnalyse du risque suicidaire au sein d’une population de personnes victimes d’actes intentionnels de violence
Garcet, Serge ULiege; Hertay, Sylvie

Conference (2002, December)

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See detailLe travail de fin d'études : quelles compétences, pour quelle formation?
Scheepers, Caroline ULiege

Scientific conference (2002, December)

La conférence est destinée aux formateurs de la Haute Ecole Léonard de Vinci et vise à leur présenter les grandes lignes de mon livre paru chez Labor.

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See detailLa Révision avant sa révision : réflexions sur une nouvelle formulation de l'article 195 de la Constitution belge
Behrendt, Christian ULiege

in Actualités du Droit (2002)

This article studies the current debate on whether a change of the amendment procedure of the Belgian Constution ought to be envisaged.

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See detailComptes-rendus du symposium « Les acarioses cutanées des animaux de compagnie en dermatologie vétérinaire »
Mignon, Bernard ULiege

Book published by Presses de la Faculté de Médecine Vétérinaire de l’Université de Liège (2002)

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See detailEntre Men et Asclépios : se soigner dans l'Asie Mineure antique
Nissen, Cécile ULiege

Scientific conference (2002, November 30)

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See detailMyoglobinurie atypique chez les chevaux au pré
Delguste, Catherine ULiege

Conference (2002, November 30)

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See detailPolymer database for encapsulation
Grandfils, Christian ULiege

Conference (2002, November 29)

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See detailDual effects of an extra disulfide bond on the activity and stability of a cold-adapted alpha-amylase
D'Amico, Salvino ULiege; Gerday, Charles ULiege; Feller, Georges ULiege

in Journal of Biological Chemistry (2002), 277(48), 46110-46115

Chloride-dependent alpha-amylases constitute a well conserved family of enzymes thereby allowing investigation of the characteristics of each member to understand, for example, relevant properties ... [more ▼]

Chloride-dependent alpha-amylases constitute a well conserved family of enzymes thereby allowing investigation of the characteristics of each member to understand, for example, relevant properties required for environmental adaptation. In this context, we have constructed a double mutant (Q58C/A99C) of the cold-active and heat-labile alpha-amylase from the Antarctic bacterium Pseudoalteromonas haloplanktis, defined on the basis of its strong similarity with the mesophilic enzyme from pig pancreas. This mutant was characterized to understand the role of an extra disulfide bond specific to warm-blooded animals and located near the entrance of the catalytic cleft. We show that the catalytic parameters of the mutant are drastically modified and similar to those of the mesophilic enzyme. Calorimetric studies demonstrated that the mutant is globally stabilized (DeltaDeltaG = 1.87 kcal/mol at 20 degrees C) when compared with the wild-type enzyme, although the melting point (T-m) was not increased. Moreover, fluorescence quenching experiments indicate a more compact structure for the mutated a-amylase. However, the strain imposed on the active site architecture induces a 2-fold higher thermal inactivation rate at 45 degreesC as well as the appearance of a less stable calorimetric domain. It is concluded that stabilization by the extra disulfide bond arises from an enthalpy-entropy compensation effect favoring the enthalpic contribution. [less ▲]

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See detailLes orientations stratégiques de la Coopération Universitaire au Développement
Marchal, Jean ULiege

(2002, November 28)

Chargée, dès 1997, à préparer et à mettre en œuvre les responsabilités nouvelles des universités francophones de Belgique dans le cadre de la coopération universitaire au développement, la C.U.D. n’a ... [more ▼]

Chargée, dès 1997, à préparer et à mettre en œuvre les responsabilités nouvelles des universités francophones de Belgique dans le cadre de la coopération universitaire au développement, la C.U.D. n’a cessé d’identifier, de définir, d’adapter, d’affiner ses orientations stratégiques. Ce processus a été celui d’un apprentissage continu : de nombreuses évaluations internes à la C.U.D., et à ses groupes de travail, une concertation continue avec les autorités publiques, le relais des institutions universitaires du sud, ont permis à la C.U.D. de consolider, tout au long de l’actuel plan quinquennal 1998-2002, les orientations stratégiques qui guident ses programmes et qui constitueront la base des travaux du prochain plan quinquennal. Dans la présente contribution, sont décrites très brièvement les principales orientations stratégiques qui servent de lignes directrices à la C.U.D. [less ▲]

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See detailLifetime measurements and calculations in singly ionized ytterbium
Biémont, Emile ULiege; Quinet, Pascal ULiege; Dai, Z. W. et al

in Journal of Physics B-Atomic Molecular and Optical Physics (2002), 35(22), 4743-4749

New radiative lifetimes, measured by time-resolved laser-induced fluorescence spectroscopy, are reported for five Rydberg states of singly ionized ytterbium. Free Yb+ ions were produced in a laser-induced ... [more ▼]

New radiative lifetimes, measured by time-resolved laser-induced fluorescence spectroscopy, are reported for five Rydberg states of singly ionized ytterbium. Free Yb+ ions were produced in a laser-induced plasma. The experimental results have been compared with HFR calculations, taking core-polarization effects into account, and a good agreement (within 25%) between theory and experiment is observed for four levels. HFR results are also proposed for np (n less than or equal to 7) and nf (n less than or equal to 8) Rydberg states and compared with available data. [less ▲]

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See detailThe influence of Space Weather and of the ionosphere on Global Navigation Satellite Systems
Warnant, René ULiege; Jodogne, Jean-Claude; Nebdi, Hamid

Conference given outside the academic context (2002)

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See detailLe poids des Églises et des sectes au Congo-Kinshasa
Melice, Anne ULiege

Conference given outside the academic context (2002)

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See detailQuelle est la place de la mémoire dans l'apprentissage du français langue seconde
Lucchini, Silvia ULiege

Conference given outside the academic context (2002)

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See detailPerinatal Group B Streptococcal Disease Prevention, Interactive session
Melin, Pierrette ULiege

Conference (2002, November 23)

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