References of "2002"
     in
Bookmark and Share    
See detailLa microchirurgie cordale, chez qui et comment?
FINCK, Camille ULg

Scientific conference (2002, December)

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailPercutaneous stereotactic en bloc excision of nonpalpable breast carcinoma: a step in the direction of supraconservative surgery
Lifrange, Eric ULg; Dondelinger, Robert ULg; Foidart, Jean-Michel ULg et al

in Breast (Edinburgh, Scotland ) (2002), 11(6), 501-508

Recently, the advanced breast biopsy instrumentation (ABBI) system has been introduced as an alternative to conventional breast biopsy techniques. This study was prospectively conducted to evaluate the ... [more ▼]

Recently, the advanced breast biopsy instrumentation (ABBI) system has been introduced as an alternative to conventional breast biopsy techniques. This study was prospectively conducted to evaluate the potential of the ABBI method in locoregional management of a consecutive series of patients with nonpalpable mammographically detected breast carcinomas. Sixty-one consecutive patients underwent an ABBI procedure as a first step before possible surgery for nonpalpable breast lesions that would in any case require complete excision. For the 27 patients in whom the ABBI biopsy revealed malignancy further surgery was recommended, including re-excision of the biopsy site and axillary dissection in cases of infiltrating carcinoma. We calculated the probabilities that the ABBI specimen would have tumor-free margins and that a definitely complete excision had been achieved as a function of the mammographic or pathological diameter of the cancer. For cancer with a pathological diameter less than 10 mm, measured on the ABBI specimen, the probability (92%) of obtaining complete resection was significantly better than for larger lesions (P = 0.01, Fisher's exact test). Although the therapeutic perspectives for the ABBI method are limited at present, we suggest that this approach is a first step in the direction of a surgical strategy that is better adapted to the pathological characteristics peculiar to these small tumors, whose incidence is increasing. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 61 (11 ULg)
Full Text
Peer Reviewed
See detailBrain function in the vegetative state
Laureys, Steven ULg; Antoine, S.; Boly, Mélanie ULg et al

in Acta Neurologica Belgica (2002), 102(4), 177-185

Positron emission tomography (PET) techniques represent a useful tool to better understand the residual brain function in vegetative state patients. It has been shown that overall cerebral metabolic rates ... [more ▼]

Positron emission tomography (PET) techniques represent a useful tool to better understand the residual brain function in vegetative state patients. It has been shown that overall cerebral metabolic rates for glucose are massively reduced in this condition. However, the recovery of consciousness from vegetative state is not always associated with substantial changes in global metabolism. This finding led us to hypothesize that some vegetative patients are unconscious not just because of a global loss of neuronal function, but rather due to an altered activity in some critical brain regions and to the abolished functional connections between them. We used voxel-based Statistical Parametric Mapping (SPM) approaches to characterize the functional neuroanatomy of the vegetative state. The most dysfunctional brain regions were bilateral frontal and parieto-temporal associative cortices. Despite the metabolic impairment, external stimulation still induced a significant neuronal activation (i.e., change in blood flow) in vegetative patients as shown by both auditory click stimuli and noxious somatosensory stimuli. However this activation was limited to primary cortices and dissociated from higher-order associative cortices, thought to be necessary for conscious perception. Finally, we demonstrated that vegetative patients have impaired functional connections between distant cortical areas and between the thalami and the cortex and, more importantly, that recovery of consciousness is paralleled by a restoration of this cortico-thalamo-cortical interaction. [less ▲]

Detailed reference viewed: 116 (32 ULg)
Full Text
See detailTraducción/minorías: iluminaciones mutuas
Willson, Patricia ULg

in Lenguas Vivas (2002), (2), 136-138

Detailed reference viewed: 23 (6 ULg)
Full Text
Peer Reviewed
See detailProjective and Affine Spatial Operators for Regions
Billen, Roland ULg; Clementini, Eliseo

in Joo Er, Meng; D'Attelis, Carlos; Mastorakis, M. (Eds.) Proceedings of WSEAS International Conferences MCBC, MCBE, ICAMSL, ICAI (2002, December)

Among Geographic Information Systems functionality is the retrieval of spatial data by using various spatial operators. The proposal of this paper is about the definition of new spatial operators that are ... [more ▼]

Among Geographic Information Systems functionality is the retrieval of spatial data by using various spatial operators. The proposal of this paper is about the definition of new spatial operators that are based on projective and affine geometric invariants. Such a special category of geometric properties, despite being not widely used in previous work, reveals itself a very interesting realm for the exploration of new operators that are both powerful and easy to use from an end-user perspective. [less ▲]

Detailed reference viewed: 37 (1 ULg)
See detailExploration de l’administrateur central de la mémoire de travail au moyen de la TEP
Collette, Fabienne ULg

Scientific conference (2002, December)

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailActive-site mutants of class B beta-lactamases: substrate binding and mechanistic study
Prosperi-Meys, C.; De Seny, Dominique ULg; Llabres, Gabriel ULg et al

in Cellular & Molecular Life Sciences (2002), 59(12), 2136-2143

Increased resistance to beta-lactam antibiotics is mainly due to beta-lactamases. X-ray structures of zinc beta-lactamases unraveled the coordination of the metal ions, but their mode of action remains ... [more ▼]

Increased resistance to beta-lactam antibiotics is mainly due to beta-lactamases. X-ray structures of zinc beta-lactamases unraveled the coordination of the metal ions, but their mode of action remains unclear. Recently, enzymes in which one of the zinc ligands was mutated have been characterized and their catalytic activity against several beta-lactam antibiotics measured. A molecular modeling study of these enzymes was performed here to explain the catalytic activity of the mutants. Coordination around the zinc ions influences the way the tetrahedral intermediate is bound; any modification influences the first recognition of the substrate by the enzyme. For all the studied mutants, at least one of the interactions fails, inducing a loss of catalytic efficiency compared to the wild type. The present studies show that the enzyme cavity is a structure of high plasticity both structurally and mechanistically and that local modifications may propagate its effects far from the mutated amino acid. [less ▲]

Detailed reference viewed: 9 (3 ULg)
See detailInformation et désinformation : le dessous des cartes
Geuens, Geoffrey ULg

Article for general public (2002)

Detailed reference viewed: 47 (16 ULg)
See detailFigures de la nuit
Havelange, Carl ULg

Book published by Ligue Braille (2002)

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailPsychomotor retardation, spastic paraplegia, cerebellar ataxia and dyskinesia associated with low 5-methyltetrahydrofolate in cerebrospinal fluid: A novel neurometabolic condition responding to folinic acid substitution
Ramaekers, Vincent ULg; Häusler, M.; Opladen, T. et al

in Neuropediatrics (2002), 33(6), 301-308

Introduction: Normal brain development and function depend on the active transport of folates across the blood-brain barrier. The folate receptor-1 (FR1) protein is localized at the basolateral surface of ... [more ▼]

Introduction: Normal brain development and function depend on the active transport of folates across the blood-brain barrier. The folate receptor-1 (FR1) protein is localized at the basolateral surface of the choroid plexus, which is characterized by a high binding affinity for circulating 5-methyltetrahydrofolate (5- MTHF). Patients and Methods: We report on the clinical and metabolic findings among five children with normal neurodevelopmental progress during the first four to six months followed by the acquisition of a neurological condition which includes marked irritability, decelerating head growth, psychomotor retardation, cerebellar ataxia, dyskinesias (choreoathetosis, ballism), pyramidal signs in the lower limbs and occasional seizures. After the age of six years the two oldest patients also manifested a central visual disorder. Known disorders have been ruled out by extensive investigations. Cerebrospinal fluid (CSF) analysis included determination of biogenic monoamines, pterins and 5-MTHF. Results: Despite normal folate levels in serum and red blood cells with normal homocysteine, analysis of CSF revealed a decline towards very low values for 5-methyltetrahydrofolate (5-MTHF), which suggested disturbed transport of folates across the blood-brain barrier. Genetic analysis of the FR1 gene revealed normal coding sequences. Oral treatment with doses of the stable compound folinic acid (0.5-1 mg/kg/day Leucovorin®) resulted in clinical amelioration and normalization of 5-MTHF values in CSF. Conclusion: Our findings identified a new condition manifesting after the age of 6 months which was accompanied by low 5-MTHF in cerebrospinal fluid and responded to oral supplements with folinic acid. However, the cause of disturbed folate transfer across the blood-brain barrier remains unknown. [less ▲]

Detailed reference viewed: 95 (1 ULg)
Full Text
Peer Reviewed
See detailPrevention of early postmenopausal bone loss by strontium ranelate: The randomized, two-year, double-masked, dose-ranging, placebo-controlled PREVOS trial
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Dougados, M. et al

in Osteoporosis International (2002), 13(12), 925-931

Early postmenopausal women (n = 160) were randomised to receive placebo or strontium ranelate (SR) 125 mg/day, 500 mg/day or 1 g/day for 2 years (40 participants per group). All participants received ... [more ▼]

Early postmenopausal women (n = 160) were randomised to receive placebo or strontium ranelate (SR) 125 mg/day, 500 mg/day or 1 g/day for 2 years (40 participants per group). All participants received calcium 500 mg/day. The primary efficacy parameter was the percent variation in lumbar bone mineral density (BMD), measured using dual-energy X-ray absorptiometry. Secondary efficacy criteria included hip BMD and biochemical markers of bone turnover. At month 24, SR I g/day significantly increased lumbar BMD compared with placebo [mean (SD) +5.53% (5.12); p < 0.001] for measured values and [mean (SD) + 1.41% (5.33%); p < 0.05] for values adjusted for bone strontium content. The annual increase for adjusted values was +0.66% compared with -0.5% with placebo, with an overall beneficial effect after 2 years of about 2.4% with SR I g/day relative to placebo. There were no other significant between-group differences in adjusted lumbar BMD. Femoral neck and total hip BMD were also significantly increased at month 24 with SR I g/day compared with placebo [mean (SD): +2.46% (4.78) and +3.21% (4.68), respectively; both p < 0.001)]. SR 1 g/day significantly increased bone alkaline phosphatase at all time points (p < 0.05) compared with baseline and between-group analysis showed a significant increase, compared with placebo, at month 18 (p = 0.048). No effect on markers of bone resorption was observed. SR was as well tolerated as placebo. The minimum does at which SR is effective in preventing bone loss in early postmenopausal non-osteoporotic women is therefore 1 g/day. [less ▲]

Detailed reference viewed: 16 (2 ULg)
Full Text
Peer Reviewed
See detailStructure and dynamics of candidate O star bubbles in N44
Nazé, Yaël ULg; Chu, Y. H.; Guerrero, M. A. et al

in Astronomical Journal (The) (2002), 124(6), 3325-3335

Dynamical studies of superbubbles and Wolf-Rayet ring nebulae show discrepancies from the standard adiabatic model for windblown bubbles. We therefore study the physical properties and kinematics of three ... [more ▼]

Dynamical studies of superbubbles and Wolf-Rayet ring nebulae show discrepancies from the standard adiabatic model for windblown bubbles. We therefore study the physical properties and kinematics of three candidate bubbles blown by single O stars to evaluate whether these discrepancies are also found in these simpler objects. Our sample candidates are N44 F, N44 J, and N44 M, in the outskirts of the H II complex N44 in the Large Magellanic Cloud. We have obtained ground-based and Hubble Space Telescope emission-line images and high-dispersion echelle spectra for these objects. From the Halpha luminosities and the [ O III]/ Halpha ratios of these nebulae, we estimate the spectral types of the ionizing stars to be O7 V, O9.5 V, and O9.5 V for N44 F, N44 J, and N44 M, respectively. We. find that the observed expansion velocity of 12 km s(-1) for N44 F is consistent with the stellar wind luminosity expected from the central ionizing star, as predicted by the standard bubble model. The observed upper limits for the expansion velocities of N44 J and N44 M are also compatible with the expected values, within the uncertainties. We also report the discovery in N44 F of strongly defined dust columns, similar to those seen in the Eagle Nebula. The photoevaporation of these dense dust features may be kinematically important and may actually govern the evolution of the shell. The inclusion of photoevaporation processes may thus undermine the apparent agreement between the observed bubble dynamics and the simple adiabatic models. [less ▲]

Detailed reference viewed: 13 (2 ULg)
Full Text
Peer Reviewed
See detailImages de la nuit. Photographie de l'altérité et altérité de la photographie
Havelange, Carl ULg

in VOIR (barré) (2002), 24-25

Detailed reference viewed: 35 (6 ULg)
Full Text
Peer Reviewed
See detailVenlafaxine: the relationship between dose, plasma concentration and clinical response in depressive patients
Charlier, Corinne ULg; Pinto, Emmanuel ULg; Ansseau, Marc ULg et al

in Journal of Psychopharmacology (2002), 16(4), 369-372

The relationship between plasma drug level of venlafaxine and daily intake was studied in 89 major depressive inpatients. In addition, changes over time in severity were assessed weekly in a subgroup of ... [more ▼]

The relationship between plasma drug level of venlafaxine and daily intake was studied in 89 major depressive inpatients. In addition, changes over time in severity were assessed weekly in a subgroup of 22 depressed patients using the Montgomery and Asberg Depression Rating Scale (MADRS) and the Clinical Global Impression improvement scale. The results indicate a moderate correlation between daily doses and plasma concentrations, together with a higher relationship between improvement on the MADRS scale and concentration. Moreover, plasma concentrations (for venlafaxine and its predominant metabolite, O-desmethylvenlafaxine) up to 400 microg/l can be considered as effective, as already suggested in a previous study. No case of venlafaxine discontinuation occurred during the longitudinal study, and the incidence of adverse event, as estimated by the Target Emergent Symptoms and Side-effects scale, was low, suggesting that the drug is well tolerated for such plasma concentrations. [less ▲]

Detailed reference viewed: 64 (4 ULg)
Full Text
See detailEtablissement de listes de sélectivité de pesticides vis-à-vis de l'entomofaune utile dans le cadre de la production intégrée en grandes cultures
Schiffers, Bruno ULg; Deleu, Rodolphe; Viatour, N. et al

in AFPP - 6ème conférence Internationale sur les Ravageurs en Agriculture (2002, December)

Detailed reference viewed: 65 (14 ULg)
See detailLe reconditionnement physique du lombalgique chronique fréquentant une école du dos : expérience au CHU-Liège
Charlier, Marie; Demoulin, Christophe ULg; Tomasella, Marco ULg et al

in Actes du First International Symposium of the Belgian Back Society (2002, December)

Detailed reference viewed: 74 (7 ULg)
See detailLe Secret des Géants
Beckers, Albert ULg

Scientific conference (2002, December)

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailSynthesis of CMR manganate compounds: the consequences of the choice of a precursor method
Vertruyen, Bénédicte ULg; Rulmont, André ULg; Cloots, Rudi ULg et al

in Materials Letters (2002), 57(3), 598-603

We have studied the electrical transport properties of manganate samples synthesized by different precursor methods. Differences in the synthesis process of the materials can result in samples with ... [more ▼]

We have studied the electrical transport properties of manganate samples synthesized by different precursor methods. Differences in the synthesis process of the materials can result in samples with similar grain size but very different physical properties, contrary to what happens in samples prepared by the same method. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

Detailed reference viewed: 46 (13 ULg)
Full Text
See detailL'Intérêt herpétologique des gares de triage de l'Entre-Sambre-et-Meuse (Belgique)
Graitson, Eric ULg

in Natura Mosana (2002), 55(4), 63-69

Detailed reference viewed: 53 (4 ULg)