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See detailVenlafaxine: the relationship between dose, plasma concentration and clinical response in depressive patients
Charlier, Corinne ULg; Pinto, Emmanuel ULg; Ansseau, Marc ULg et al

in Journal of Psychopharmacology (2002), 16(4), 369-372

The relationship between plasma drug level of venlafaxine and daily intake was studied in 89 major depressive inpatients. In addition, changes over time in severity were assessed weekly in a subgroup of ... [more ▼]

The relationship between plasma drug level of venlafaxine and daily intake was studied in 89 major depressive inpatients. In addition, changes over time in severity were assessed weekly in a subgroup of 22 depressed patients using the Montgomery and Asberg Depression Rating Scale (MADRS) and the Clinical Global Impression improvement scale. The results indicate a moderate correlation between daily doses and plasma concentrations, together with a higher relationship between improvement on the MADRS scale and concentration. Moreover, plasma concentrations (for venlafaxine and its predominant metabolite, O-desmethylvenlafaxine) up to 400 microg/l can be considered as effective, as already suggested in a previous study. No case of venlafaxine discontinuation occurred during the longitudinal study, and the incidence of adverse event, as estimated by the Target Emergent Symptoms and Side-effects scale, was low, suggesting that the drug is well tolerated for such plasma concentrations. [less ▲]

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See detailEtablissement de listes de sélectivité de pesticides vis-à-vis de l'entomofaune utile dans le cadre de la production intégrée en grandes cultures
Schiffers, Bruno ULg; Deleu, Rodolphe; Viatour, N. et al

in AFPP - 6ème conférence Internationale sur les Ravageurs en Agriculture (2002, December)

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See detailLe reconditionnement physique du lombalgique chronique fréquentant une école du dos : expérience au CHU-Liège
Charlier, Marie; Demoulin, Christophe ULg; Tomasella, Marco ULg et al

in Actes du First International Symposium of the Belgian Back Society (2002, December)

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See detailLe Secret des Géants
Beckers, Albert ULg

Scientific conference (2002, December)

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See detailSynthesis of CMR manganate compounds: the consequences of the choice of a precursor method
Vertruyen, Bénédicte ULg; Rulmont, André ULg; Cloots, Rudi ULg et al

in Materials Letters (2002), 57(3), 598-603

We have studied the electrical transport properties of manganate samples synthesized by different precursor methods. Differences in the synthesis process of the materials can result in samples with ... [more ▼]

We have studied the electrical transport properties of manganate samples synthesized by different precursor methods. Differences in the synthesis process of the materials can result in samples with similar grain size but very different physical properties, contrary to what happens in samples prepared by the same method. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailL'Intérêt herpétologique des gares de triage de l'Entre-Sambre-et-Meuse (Belgique)
Graitson, Eric ULg

in Natura Mosana (2002), 55(4), 63-69

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See detailUse of simulation in the commissioning of an office building
Andre, Philippe ULg; Lacôte, P.; Adam, Ch. et al

in Proceedings of SSB'2002 congress (2002, December)

In the frame of two successive IEA-ECBCS annexes, the « CA-MET » building in Namur was the object of commissioning and re-commissioning activities. First, during the construction of the building and ... [more ▼]

In the frame of two successive IEA-ECBCS annexes, the « CA-MET » building in Namur was the object of commissioning and re-commissioning activities. First, during the construction of the building and installation of the HVAC plant, a systematic survey of the work was carried out in the frame of IEA Annex 34 (“Fault Detection”). Therefore, attention was paid to a specific part of the plant (a typical Air handling Unit) and a number of testing and verifications were performed, as a complement to the normal and ongoing commissioning activities: - testing and balancing of air and water networks - air flowrate measurements - water flowrate measurements - control system analysis The most important faults identified in this part of the project were classified according to the IEA 34 template and, for each of these faults, the possibility of developing an automatic fault detection method was analysed. The paper will report on the most relevant problems and present the automatic fault detection method proposed. In a second step, which occurred during in the early stages of the operational phase of the building, a further verification of specific subsystems was carried out, as part of a re-commissioning activity. This work is being realized in the frame of IEA Annex 40 and ends up with a proposal of systematic verification procedure to be applied, as a first example, to a VAV system. This procedure follows a hierarchical approach (bottom-up), starting with the local VAV loop, going through the AHU and ending with the chilled water production equipment. The paper reports on the application of the procedure to the selected building and will be based upon experimental results obtained during target monitoring campaigns. [less ▲]

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See detailSimulation of a non conventional HVAC plant in an experimental building devoted to artificial fog production.
Andre, Philippe ULg; Boreux, Jean-Jacques ULg; Lacôte, P. et al

in Proceedings of SSB'2002 Congress (2002, December)

In the frame of a european project dealing with the issue of transport safety improvement in fog conditions, a new experimental building is being constructed on the FUL campus, in the southern part of ... [more ▼]

In the frame of a european project dealing with the issue of transport safety improvement in fog conditions, a new experimental building is being constructed on the FUL campus, in the southern part of Belgium. This building hosts a climatic chamber in which a given indoor climate is to be maintained (temperature and relative humidity) whatever the external climate. Control of the internal climate will be performed by means of a specific HVAC plant. The general environmental context of the project led to the selection of non conventional solutions for the plant: solar collectors (both thermal and photovoltaic) are associated with a reversible heat pump in order to either heat or cool the building. In some circumstances, simultaneous heating and cooling of different rooms of the building will be necessary and possible. Energy distribution within the building will be made possible by different systems: - floor heating and/or cooling - cooling or heating ceiling - ventilation and Air handling Unit The paper reports on the use of building and HVAC system simulation in order to support the design of the plant. Simulation is carried out in the TRNSYS environment and gathers the following components: building, reversible heat pump, thermal solar collectors, photovoltaic solar collectors, floor heating, cooling ceiling, Air Handling Unit, storage tanks. Parameters identification for the different components will be developed. The paper will focus on specific problems connected to the simultaneous control of both temperature and relative humidity in situation close to the saturation state. The whole design methodology will be situated in the general context of the building life cycle and will make use of some ideas presented in the IEA Annex 30 research project. [less ▲]

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See detailIce storage system (ISS) : phase change modelling (TRNSYS 15). Simulation of a typical HVAC primary plant equipped with an ice sotrage unit.
Adam, Ch.; Andre, Philippe ULg

in Proceedings of SSB'2002 congress (2002, December)

An ice storage can be an interesting option in a HVAC plant. It reduces the electricity costs and increases the HVAC plant capabilities. ISS reduces the on-peak power and shifts the cooling demand from ... [more ▼]

An ice storage can be an interesting option in a HVAC plant. It reduces the electricity costs and increases the HVAC plant capabilities. ISS reduces the on-peak power and shifts the cooling demand from the on-peak hours to the off-peak hours. ISS increases the available HVAC plant power, and then, the internal comfort. To store cold energy requires the selection of operating strategies. The objective of these strategies is to meet the global cooling demand of the building. Each strategy offers different technical and economical characteristics. The typical questions the manager of an HVAC plant has to solve are: Which is optimal ice storage tank in my case? Which cooling power? Which cooling capacity? How to run the HVAC plant to minimize the cost? To compare objectively the strategies, the manager needs to reproduce the ISS performances for the same conditions (building, cooling and electrical demands, climate conditions,...). He needs also informations to chose the appropriate plant configuration or operating strategy to meet the global cooling demand taking into account the characteristics of the tank, of the demand curve,... at each moment. A simulation model of an entire HVAC primary plant should provide this information. [less ▲]

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See detailStudy of color centers induced by PIXE irradiation
Absil, J.; Garnir, Henri-Pierre ULg; Strivay, David ULg et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (2002), 198(1-2), 90-97

The particle induced X-ray emission method is perfectly adapted to the study, by external beam, of art objects (like paintings) and allows non-destructive analysis of the atomic composition of the target ... [more ▼]

The particle induced X-ray emission method is perfectly adapted to the study, by external beam, of art objects (like paintings) and allows non-destructive analysis of the atomic composition of the target. However, a strange phenomenon occurs during irradiation on some pigments: dark brownish stains appear, and this could be due to the formation of color centers. In fact, these darkening spots progressively fade out and disappear after a few weeks. Heat and UV light accelerate the decreasing process. The aim of this study is to understand the physical processes of the stain creation and to find a way to make stains disappear, avoiding any damage for the painting. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailApplication of Supercritical carbon dioxide for the preparation of drug-cyclodextrin inclusion compounds
Van Hees, Thierry ULg; Barillaro, Valery; Piel, Géraldine ULg et al

in Journal of Inclusion Phenomena and Macrocyclic Chemistry (2002), 44(1-4), 271-274

Inclusion complexes of drugs into cyclodextrins (CDs) can be obtained at the solid state by means of supercritical dioxide (SCCO2). A successful inclusion with a yield >98.5% has been achieved with ... [more ▼]

Inclusion complexes of drugs into cyclodextrins (CDs) can be obtained at the solid state by means of supercritical dioxide (SCCO2). A successful inclusion with a yield >98.5% has been achieved with piroxicam and beta-CD. The temperature and the time of exposure to SCCO2 have a significant effect on the inclusion yield while the pressure has a negative effect. However, there is a strong interaction between temperature and pressure and this interaction has a positive influence. The molar ratio piroxicam-beta-CD and the addition of ternary alkaline agents were also found to be significant factors. The dissolution rate of the complexes formed using SCCO2 was found to be significantly higher than that of the physical mixture. Inclusion complexes have also been obtained with miconazole treating mixtures of miconazole, CDs and citric acid by SCCO2. This new technique of inclusion of poorly soluble drugs into CDs allows the preparation of solid complexes without using organic solvents and thus without residues. [less ▲]

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See detailMyoglobinurie atypique chez les chevaux au pré
Delguste, Catherine ULg

Conference (2002, November 30)

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See detailComptes-rendus du symposium « Les acarioses cutanées des animaux de compagnie en dermatologie vétérinaire »
Mignon, Bernard ULg

Book published by Presses de la Faculté de Médecine Vétérinaire de l’Université de Liège (2002)

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See detailEntre Men et Asclépios : se soigner dans l'Asie Mineure antique
Nissen, Cécile ULg

Scientific conference (2002, November 30)

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See detailPolymer database for encapsulation
Grandfils, Christian ULg

Conference (2002, November 29)

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See detailDual effects of an extra disulfide bond on the activity and stability of a cold-adapted alpha-amylase
D'Amico, Salvino ULg; Gerday, Charles ULg; Feller, Georges ULg

in Journal of Biological Chemistry (2002), 277(48), 46110-46115

Chloride-dependent alpha-amylases constitute a well conserved family of enzymes thereby allowing investigation of the characteristics of each member to understand, for example, relevant properties ... [more ▼]

Chloride-dependent alpha-amylases constitute a well conserved family of enzymes thereby allowing investigation of the characteristics of each member to understand, for example, relevant properties required for environmental adaptation. In this context, we have constructed a double mutant (Q58C/A99C) of the cold-active and heat-labile alpha-amylase from the Antarctic bacterium Pseudoalteromonas haloplanktis, defined on the basis of its strong similarity with the mesophilic enzyme from pig pancreas. This mutant was characterized to understand the role of an extra disulfide bond specific to warm-blooded animals and located near the entrance of the catalytic cleft. We show that the catalytic parameters of the mutant are drastically modified and similar to those of the mesophilic enzyme. Calorimetric studies demonstrated that the mutant is globally stabilized (DeltaDeltaG = 1.87 kcal/mol at 20 degrees C) when compared with the wild-type enzyme, although the melting point (T-m) was not increased. Moreover, fluorescence quenching experiments indicate a more compact structure for the mutated a-amylase. However, the strain imposed on the active site architecture induces a 2-fold higher thermal inactivation rate at 45 degreesC as well as the appearance of a less stable calorimetric domain. It is concluded that stabilization by the extra disulfide bond arises from an enthalpy-entropy compensation effect favoring the enthalpic contribution. [less ▲]

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