References of "2002"
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See detailNovel bioresorbable and bioactive composites based on bioactive glass and polylactide foams for bone tissue engineering
Roether, J. A.; Gough, J. E.; Boccaccini, Aldo R. et al

in Journal of Materials Science: Materials in Medicine (2002), 13(12), 1207-1214

Bioresorbable and bioactive tissue engineering scaffolds based on bioactive glass (45S5 Bioglass®) particles and macroporous poly(DL-lactide) (PDLLA) foams were fabricated. A slurry dipping technique in ... [more ▼]

Bioresorbable and bioactive tissue engineering scaffolds based on bioactive glass (45S5 Bioglass®) particles and macroporous poly(DL-lactide) (PDLLA) foams were fabricated. A slurry dipping technique in conjunction with pretreatment in ethanol was used to achieve reproducible and well adhering bioactive glass coatings of uniform thickness on the internal and external surfaces of the foams. In vitro studies in simulated body fluid (SBF) demonstrated rapid hydroxyapatite (HA) formation on the surface of the composites, indicating their bioactivity. For comparison, composite foams containing Bioglass® particles as filler for the polymer matrix (in concentration of up to 40 wt%) were prepared by freeze-drying, enabling homogenous glass particle distribution in the polymer matrix. The formation of HA on the composite surfaces after immersion in phosphate buffer saline (PBS) was investigated to confirm the bioactivity of the composites. Human osteoblasts (HOBs) were seeded onto as-fabricated PDLLA foams and onto PDLLA foams coated with Bioglass® particles to determine early cell attachment and spreading. Cells were observed to attach and spread on all surfaces after the first 90 min in culture. The results of this study indicate that the fabricated composite materials have potential as scaffolds for guided bone regeneration. (C) 2002 Kluwer Academic Publishers. [less ▲]

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See detailLa carcinomatose hepatique du cancer colorectal: actualites therapeutiques
Polus, Marc ULg; Honore, Pierre ULg; De Roover, Arnaud ULg et al

in Revue Médicale de Liège (2002), 57(12), 771-8

Important progress has been made in the treatment of liver metastases of advanced colorectal cancer. Surgery with curative intent, when possible, shows evidence of prolonged survival. Response rate and ... [more ▼]

Important progress has been made in the treatment of liver metastases of advanced colorectal cancer. Surgery with curative intent, when possible, shows evidence of prolonged survival. Response rate and overall survival can be improved with modern polychemotherapy. Cytotoxic drug combinations and sequential treatments sometimes make surgery possible for initially non resectable lesions. Impact of loco-regional treatment such as hepatic arterial infusion chemotherapy must be defined in randomised trials. Radiofrequency ablation is also currently evaluated in clinical trials. In this review the benefit of each treatment is discussed. [less ▲]

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See detailOptimization of the separation of beta-blockers by ion-pair capillary electrophoresis in non-aqueous media using univariate and multivariate approaches
Servais, Anne-Catherine ULg; Fillet, Marianne ULg; Chiap, Patrice ULg et al

in Journal of Separation Science (2002), 25(15-17), 1087-1095

The separation of four beta-blocking drug substances (atenolol, sotalol, betaxolol, and metoprolol) selected as model basic analytes has been investigated in non-aqueous capillary electrophoresis (NACE ... [more ▼]

The separation of four beta-blocking drug substances (atenolol, sotalol, betaxolol, and metoprolol) selected as model basic analytes has been investigated in non-aqueous capillary electrophoresis (NACE) using the principle of ion-pair formation. Camphorsulphonate was selected as the counter-ion in a background electrolyte (BGE) made up of formate buffer in a mixture of acetonitrile/methanol or acetonitrile/ethanol. The influence on resolution of the concentration of the counter-ion, the nature and proportion of the organic solvents, as well as the concentration of the ionic components of the BGE was first studied by a univariate approach. An experimental design was then applied to estimate possible quadratic effects and first-order interactions. To identify the most important factors affecting the separation of the four beta-blockers, a two-level fractional factorial design with 16 experimental points was applied as a screening test. A three factor Box-Behnken design with 12 experimental points was used to predict and optimize the selectivity. Finally the optimal conditions obtained by the univariate and the multivariate, approaches were compared. [less ▲]

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See detailCaractérisation de la résistance au Sénégal d'Helicoverpa armigera Hubner (Lépidoptère, Noctuidae) par bioessai et méthodes moléculaires
Moreira, Christine; Schiffers, Bruno ULg; Haubruge, Eric ULg

in AFPP - 6ème Conférence Internationale sur les Ravageurs en Agriculture (2002, December)

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See detailIntermittent Versus Continuous Total Androgen Blockade in the Treatment of Patients with Advanced Hormone-Naive Prostate Cancer: Results of a Prospective Randomized Multicenter Trial
De Leval, Jean ULg; Boca, Philippe; Yousef, Enis et al

in Clinical Prostate Cancer (2002), 1(3), 163-71

The aim of this study was to compare the efficacy of total intermittent androgen deprivation (IAD) versus total continuous androgen deprivation (CAD) for treating patients with advanced prostate cancer in ... [more ▼]

The aim of this study was to compare the efficacy of total intermittent androgen deprivation (IAD) versus total continuous androgen deprivation (CAD) for treating patients with advanced prostate cancer in a phase III randomized trial. A total of 68 evaluable patients with hormone-naive advanced or relapsing prostate cancer were randomized to receive combined androgen blockade according to a continuous (n = 33) or intermittent (n = 35) regimen. Therapeutic monitoring was assessed by use of serum prostate-specific antigen (PSA) measurements. Patients in the CAD and IAD groups were equally stratified for age, biopsy Gleason score, and baseline serum PSA levels. The outcome variable was time to androgen-independence of the tumor, which was defined as increasing serum PSA levels despite androgen blockade. Mean follow-up was 30.8 months. The 35 IAD-treated patients completed 91 cycles, and 19 of them (54.3%) completed > or = 3 cycles. Median cycle length and percentage of time off therapy were 9.0 months and 59.5, respectively. The estimated 3-year progression rate was significantly lower in the IAD group (7.0% +/- 4.8%) than in the CAD group (38.9% +/- 11.2%, P = 0.0052). Our data suggest that IAD treatment may maintain the androgen-dependent state of advanced human prostate cancer, as assessed by PSA measurements, at least as long as CAD treatment. Further studies with longer follow-up times and larger patient cohorts are needed to determine the comparative impacts of CAD and IAD on survival. [less ▲]

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See detailSite effect analysis around the seismically induced Ananevo, Rockslide, Kyrgyzstan
Havenith, Hans-Balder ULg; Jongmans, D.; Faccioli, E. et al

in Bulletin of the Seismological Society of America (2002), 92(8), 3190-3209

In 1911, the surface-wave magnitude 8.2 Kemin earthquake hit northeastern Tien Shan (Kyrgyzstan), close to the cities of Bishkek and Almaty, the capitals of Kyrgyzstan and Kazakhstan, respectively ... [more ▼]

In 1911, the surface-wave magnitude 8.2 Kemin earthquake hit northeastern Tien Shan (Kyrgyzstan), close to the cities of Bishkek and Almaty, the capitals of Kyrgyzstan and Kazakhstan, respectively. Several hundreds of people were killed by the earthquake, some by indirect effects such as landslides and mudflows. A particular but nonfatal landslide triggered by the Kemin event was a rockslide in the vicinity of Ananevo, north of lake Issyk Kul (Kyrgyzstan) rockslide located above the fault zone activated in 1911. In the summer of 1999, a geophysical-seismological field trip was organized to study geology and to record seismic ground motions on and around the Ananevo rockslide. The work was part of project assessing seismogenic landslide hazard in northern Kyrgyzstan, based on various case studies of slope failures in connection with site-specific ground-motion dynamics. The geophysical investigations consisted of seismic refraction tests processed as 2D seismic tomographies and surface-wave inversion, which were combined to build a 3D geophysical model of the landslide site. Ground motions from small earthquakes were analyzed using several techniques to define site effects over the mountain massif. Both H/V and standard spectral ratios indicated lower dominant frequencies with stronger amplification in the crest region with respect to the mountain slope. These effects could be partially simulated by I D, 2D, and 3D finite-element modeling. By comparing the numerical results with the experimental data, the presence of a surficial low-velocity layer of varying thickness appeared to be the key factor controlling the ground motion around the rockslide. [less ▲]

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See detailSevere lower gastrointestinal bleeding in Crohn's disease: Successful control with infliximab
Berlaiche, J.; Louis, Edouard ULg

in American Journal of Gastroenterology (2002), 97(12), 3210-3211

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See detailThe north-eastern Polish anorthosite massifs: petrological, geochemical and isotopic evidence for a crustal derivation
Wiszniewska, Janina; Claesson, Stefan; Stein, Holly et al

in Terra Nova (2002), 14(6), 451-460

Deeply buried 1.5 Ga Polish anorthosites, accessible only by bore holes, reveal diagnostic features of some massif-type anorthosites (polybarism, jotunitic parent magma), diapirically emplaced in the mid ... [more ▼]

Deeply buried 1.5 Ga Polish anorthosites, accessible only by bore holes, reveal diagnostic features of some massif-type anorthosites (polybarism, jotunitic parent magma), diapirically emplaced in the mid crust together with the rapakivi granites of the EW-trending Mazury complex, intruded along a major crustal discontinuity. Geochemical modelling and isotope data corroborate recent experimental work on the basaltic system in dry conditions: the source rock of the parental magma is a gabbronorite, necessarily lying in the lower crust. Since no Archaean crust is known in the region, high initial Os-188/Os-187 ratios for sulphide-oxide isochrons and negative epsilon(Nd) values are best accounted for by melting a similar to 2.0 Ga mafic crust. [less ▲]

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See detailAlkali cation attachment to derivatized fullerenes studied by matrix-assisted laser desorption/ionization
Fati, D.; Leeman, V.; Vasil'ev, Y. V. et al

in Journal of the American Society for Mass Spectrometry (2002), 13(12), 1448-1458

The complexation of alkali metal ions with amphiphilic fullerene derivatives has been investigated by matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry. The ... [more ▼]

The complexation of alkali metal ions with amphiphilic fullerene derivatives has been investigated by matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry. The formation of analyte ions occurs via two competing mechanisms including electron transfer from matrix-derived ions and metal ion attachment. The interplay of these processes has been examined by laser fluence dependent sample activation and by variation of the target composition. The attachment of metal ions has been established as the gentler and thus more efficient route towards the formation of intact analyte ions. Investigations into the metal ion complexation have been conducted to reveal the reactivity order of the alkali metals in these reactions and to elucidate the influence of structural differences of the analytes, as well as to unravel effects caused by the anionic counter ion of the metal. The experimental data have been derived by two complementary approaches. Competing reactants were either studied simultaneously, so that the product distribution would provide direct insight into the reactivity pattern, and/or product distributions were obtained in a large variety of separate experiments and normalized for reliable comparison. It has been found that the extent to which complexation is observed follows the charge density order of the alkali metal ions. The structural features of the fullerene-attached ligands were of profound influence on the attachment of the metal ion, inducing enhanced selectivity for the complexation with less reactive metals. The metal ion attachment is reduced with the use of smaller anionic counter ions. Rationalization of these findings is provided within the framework of the mechanisms of ion formation in MALDI. [less ▲]

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See detailThe in situ formation of a new initiator system for the syndiotactic anionic polymerization of methyl methacrylate in toluene at 0°C
Zundel, Thomas; Teyssié, Philippe; Jérôme, Robert ULg

in Polymer (2002), 43(25), 7191-7193

This paper reports on an efficient 'in-situ' one pot synthesis of an initiatior/ligand adduct, which can be used to initiate the anionic polymerization of methyl methacrylate in toluene at 0 °C ... [more ▼]

This paper reports on an efficient 'in-situ' one pot synthesis of an initiatior/ligand adduct, which can be used to initiate the anionic polymerization of methyl methacrylate in toluene at 0 °C. Predominantly syndiotactic PMMA is formed. [less ▲]

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See detailRadiographic, computed tomographic, magnetic resonance and rhinoscopic findings in dogs with nasal aspergillosis
Saunders, J.; Clercx, Cécile ULg; CABAY, Jean-Evrard ULg et al

in Annual Meeting of ACVR - Chicago, Illinois - USA - Décembre 2002 (2002, December)

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See detailMise au point et traitement des traumatismes pancreatiques chez l'enfant
Devoitille, A.; Dominé, Françoise; De Roover, Arnaud ULg et al

in Revue Médicale de Liège (2002), 57(12), 760-4

Pancreatic injury after trauma can occur in the child as an isolated lesion after a minor injury. The consequences can be severe in the absence of prompt diagnosis and treatment. Determination of ... [more ▼]

Pancreatic injury after trauma can occur in the child as an isolated lesion after a minor injury. The consequences can be severe in the absence of prompt diagnosis and treatment. Determination of mechanism of injury, clinical examination, blood amylase levels and abdominal CT-scan are first line steps for the evaluation of the injury. ERCP and MRI can be useful tools to further document injury to the pancreatic duct. In the absence of duct injury, conservative treatment can be applied. For the other cases, the treatment is surgical although newer techniques may be applied in selected cases. [less ▲]

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See detailThe neural substrates of the central executive: Exploration of the updating and shifting processes
Collette, Fabienne ULg; Van der Linden, Martial ULg; Delchambre, Marie et al

Conference (2002, December)

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See detailOn the Model Validation in Nonlinear structural Dynamics,
Kerschen, Gaëtan ULg

Doctoral thesis (2002)

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See detailLa microchirurgie cordale, chez qui et comment?
FINCK, Camille ULg

Scientific conference (2002, December)

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See detailPercutaneous stereotactic en bloc excision of nonpalpable breast carcinoma: a step in the direction of supraconservative surgery
Lifrange, Eric ULg; Dondelinger, Robert ULg; Foidart, Jean-Michel ULg et al

in Breast (Edinburgh, Scotland ) (2002), 11(6), 501-508

Recently, the advanced breast biopsy instrumentation (ABBI) system has been introduced as an alternative to conventional breast biopsy techniques. This study was prospectively conducted to evaluate the ... [more ▼]

Recently, the advanced breast biopsy instrumentation (ABBI) system has been introduced as an alternative to conventional breast biopsy techniques. This study was prospectively conducted to evaluate the potential of the ABBI method in locoregional management of a consecutive series of patients with nonpalpable mammographically detected breast carcinomas. Sixty-one consecutive patients underwent an ABBI procedure as a first step before possible surgery for nonpalpable breast lesions that would in any case require complete excision. For the 27 patients in whom the ABBI biopsy revealed malignancy further surgery was recommended, including re-excision of the biopsy site and axillary dissection in cases of infiltrating carcinoma. We calculated the probabilities that the ABBI specimen would have tumor-free margins and that a definitely complete excision had been achieved as a function of the mammographic or pathological diameter of the cancer. For cancer with a pathological diameter less than 10 mm, measured on the ABBI specimen, the probability (92%) of obtaining complete resection was significantly better than for larger lesions (P = 0.01, Fisher's exact test). Although the therapeutic perspectives for the ABBI method are limited at present, we suggest that this approach is a first step in the direction of a surgical strategy that is better adapted to the pathological characteristics peculiar to these small tumors, whose incidence is increasing. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailProjective and Affine Spatial Operators for Regions
Billen, Roland ULg; Clementini, Eliseo

in Joo Er, Meng; D'Attelis, Carlos; Mastorakis, M. (Eds.) Proceedings of WSEAS International Conferences MCBC, MCBE, ICAMSL, ICAI (2002, December)

Among Geographic Information Systems functionality is the retrieval of spatial data by using various spatial operators. The proposal of this paper is about the definition of new spatial operators that are ... [more ▼]

Among Geographic Information Systems functionality is the retrieval of spatial data by using various spatial operators. The proposal of this paper is about the definition of new spatial operators that are based on projective and affine geometric invariants. Such a special category of geometric properties, despite being not widely used in previous work, reveals itself a very interesting realm for the exploration of new operators that are both powerful and easy to use from an end-user perspective. [less ▲]

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