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See detailEffect of risedronate on the risk of hip fracture in elderly women
McClung, MR; Geusens, P; Miller, PD et al

in Clinical Rheumatology (2001), 20

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See detailThe lipid phosphatase SHIP2 controls insulin sensitivity
Clément, S.; Krause, U.; Desmedt, F. et al

in Nature (2001), 409

Insulin is the primary hormone involved in glucose homeostasis, and impairment of insulin action and/or secretion has a critical role in the pathogenesis of diabetes mellitus. Type-II SH2-domain ... [more ▼]

Insulin is the primary hormone involved in glucose homeostasis, and impairment of insulin action and/or secretion has a critical role in the pathogenesis of diabetes mellitus. Type-II SH2-domain-containing inositol 5-phosphatase, or 'SHIP2', is a member of the inositol polyphosphate 5-phosphatase family. In vitro studies have shown that SHIP2, in response to stimulation by numerous growth factors and insulin, is closely linked to signalling events mediated by both phosphoinositide-3-OH kinase and Ras/mitogen-activated protein kinase. Here we report the generation of mice lacking the SHIP2 gene. Loss of SHIP2 leads to increased sensitivity to insulin, which is characterized by severe neonatal hypoglycaemia, deregulated expression of the genes involved in gluconeogenesis, and perinatal death. Adult mice that are heterozygous for the SHIP2 mutation have increased glucose tolerance and insulin sensitivity associated with an increased recruitment of the GLUT4 glucose transporter and increased glycogen synthesis in skeletal muscles. Our results show that SHIP2 is a potent negative regulator of insulin signalling and insulin sensitivity in vivo [less ▲]

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See detailRole de l'inhibiteur des activateurs de plasminogene de type 1 dans l'angiogenese tumorale
Bajou, Khalid ULg; Devy, L.; Masson, Véronique ULg et al

in Thérapie (2001), 56(5, Sep-Oct), 465-72

The plasminogen/plasmin system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumour cell migration. High levels of components of the plasminogen ... [more ▼]

The plasminogen/plasmin system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumour cell migration. High levels of components of the plasminogen activation system, and paradoxically also its inhibitor, plasminogen activator inhibitor 1 (PAI-1), have been correlated with a poor prognosis for patients with cancers of different types. Recent findings clearly suggest that PAI-1 is essential for capillary sprouting during tumour angiogenesis. Moreover, there is accumulating evidence that both the urokinase receptor and PAI-1 are multifunctional proteins involved not only in extracellular matrix proteolysis but also in cellular adhesion and migration through their binding site for vitronectin. The understanding of whether PAI-1 plays a regulatory role in angiogenesis by tightly controlling proteolytic activity or by influencing cell migration could allow a new anti-angiogenic approach for tumour therapy. [less ▲]

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See detailRegime alimentaire du Grand-Duc du désert, Bubo ascalaphus, dans la réserve naturelle de Mergueb (M'Sila, Algérie)
Biche, Mohamed; Sellami, Medhi; Libois, Roland ULg et al

in Alauda (2001), 69(4), 554-557

The diet of Bubo ascalaphus was studied in a steppe at the Mergueb nature reserve. The analysis of 141 pellets indicated that mammals were most abundant (89 %). The most frequent prey, on a numerical ... [more ▼]

The diet of Bubo ascalaphus was studied in a steppe at the Mergueb nature reserve. The analysis of 141 pellets indicated that mammals were most abundant (89 %). The most frequent prey, on a numerical basis (82 %) as well as in term of biomass (96 %) was Meriones shawi trouessarti (Gerbillidae). Other preys included Jaculus orientalis (Dipodidae), and two insectivores: Crocidura russula and Hemiechinus aethiopicus. Among the avifauna, only the Spanish sparrow (Passer hispaniolensis) was a significant part of the Eagle owl dietn especially in spring. Arthropods were represented by Scarabeidae in spring and Scorpionidae in summer but they played a minor role in the food of the Eagle owl. The originality of this diet lies in the absence of Brown hare (Lepus capensis) and the presence of only one specimen of the desert hedgehog. Although its food spectrum was very narrow in this site, the Eagle owl can be regarded as opportunistic as it concentrated on the most available prey: Meriones shawi. [less ▲]

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See detailRapid and sustained hip fracture risk reduction with risedronate in elderly women with osteoporosis
Cooper, C; Reginster, Jean-Yves ULg; McClung, M et al

in BONE (2001), S28

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See detailThe effect of risedronate on hip fracture risk in elderly women with osteoporosis
Bensen, W; Eastell, R; Reginster, Jean-Yves ULg et al

in Journal of Rheumatology (2001), 28(S63), 24

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See detailA simple clinical tool to identify Asian women with osteoporosis
Lou, SQ; Koh, L; Yang, BY et al

in Journal of Rheumatology (2001), 28(S63), 26

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See detailLe cotonnier
Peeters, C.; Louwagie, J.; Van Lagenhove, L. et al

in Agriculture en Afrique tropicale (2001)

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See detailLife-cycle modelling of bequests and its implications for annuity valuation
Jousten, Alain ULg

in Journal of Public Economics (2001), 79

In this paper we introduce a linear bequest motive into a standard life-cycle model, both allowing for credit and annuity market imperfections. First, we characterize the consumption and wealth processes ... [more ▼]

In this paper we introduce a linear bequest motive into a standard life-cycle model, both allowing for credit and annuity market imperfections. First, we characterize the consumption and wealth processes.We find that consumption is non-increasing in the linear bequest parameter for the simplest certainty case, but that the same is not true for life-span uncertainty. Second, we study the issue of annuity valuation. For a sufficiently strong bequest motive, the true value of an annuity is equal to the actuarial value. This invalidates a previous claim that, for imperfect annuity markets, it is close to the simple financial value. [less ▲]

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See detailSustained fracture benefit with five years of risedronate in postmenopausal women
Hosking, D; Sorensen, OD; Mulder, H et al

in BONE (2001), S28

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See detailRelatifs de liaison et temps verbaux chez les historiens latins
Longrée, Dominique ULg

Scientific conference (2001)

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See detailSémiologie cardiaque dans l’espèce équine. 1- L’anamnèse et l’examen clinique.
Amory, Hélène ULg

in Pratique Vétérinaire Equine (2001), 33

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See detailCompact holographic camera based on photorefractive crystals and application in interferometry
Georges, Marc ULg; Scauflaire, Véronique; Lemaire, Philippe

in Optical Materials (2001), 18

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See detailRelationship between estrogen precursors, estradiol, body mass index and bone mineral dentiy in elderly women at risk of osteoporotic fractures
Zmierczak, H; Goemaere, S; Daems, M et al

in Clinical Rheumatology (2001), 20

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See detailFacial mimicry and emotional contagion to dynamic emotional facial expression and their influence on decoding accuracy
Hess, U; Blairy, Sylvie ULg

in International Journal of Psychophysiology (2001), 40

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See detailA methodological approach towards assessment of land-use and land-cover change
Bogaert, Jan ULg; Ceulemans, R; Myneni, R B

Poster (2001)

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See detailDetectie van enteropathogene Escherichia coli bij vleeskonijnen : Een nieuwe diagnostische test
Vandekerckhove, D; Chow, TT; Callebaut, A et al

Book published by Ministère de l'Agriculture et des Classes Moyennes (2001)

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See detailCulture of very young Phaseolus vulgaris L. pods and plantlet regeneration.
Geerts, P.; Toussaint, André ULg; Mergeai, Guy ULg et al

in Acta Horticulture 560 : Proceedings of the Fourth International Symposium on In Vitro Cultureand Horticultural Breeding (2001)

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