Levels and Profile of PCDD/Fs and cPCBs in Walloon Breast Milk from Industrial Area

Poster (2001, November)

Genesis of Clone Size Heterogeneity in Megakaryocytic and Other Hemopoietic Colonies: The Stochastic Model Revisited

in Experimental Hematology (2001), 29(11), 1256-69

OBJECTIVE: We previously showed that the distributions of the numbers of doublings (NbD) undergone by individual megakaryocyte progenitors before commitment to polyploidization are markedly skewed and can ... [more ▼]

OBJECTIVE: We previously showed that the distributions of the numbers of doublings (NbD) undergone by individual megakaryocyte progenitors before commitment to polyploidization are markedly skewed and can consistently be fitted to straight lines when plotted on semilogarithmic coordinates. The slope of such lines, which yields the probability of polyploidization per doubling, is made less steep by stimulators of megakaryocyte colony formation and is less steep in mixed erythroid-megakaryocyte than in pure megakaryocyte colonies. Therefore, megakaryocytopoiesis provides a unique model for the study of clonal heterogeneity in a hemopoietic lineage, which is the subject of this review. DATA SOURCES: Articles relevant to the interpretation of these data were selected from the authors' and public databases. DATA SYNTHESIS: Exponential NbD distributions were first explained by postulating that following the assembly of thrombopoiesis-specific regulators, megakaryocyte progenitors require only a single random event to arrest proliferation and commit to polyploidization. However, this stochastic model was refuted by data indicating that intrinsic properties of individual progenitors affect the NbD they achieve. We suggest that the unequal repartition of critical compounds (including receptors, signaling molecules, and gene regulators) inherent in the stem cell-progenitor transition causes a heritable heterogeneity in megakaryocyte progenitor responsiveness to polyploidization inducers. This model would be compatible with 1) the evidence for intraclonal synchronization in megakaryocyte and other hemopoietic clones generated by committed progenitors; 2) the low probability of polyploidization of the relatively insensitive bipotent megakaryocyte progenitors; and 3) the thesis that stimulators act in part by recruiting megakaryocyte progenitor cells endowed with lesser responsiveness to polyploidization inducers and higher proliferative potential. CONCLUSION: The responsiveness of individual megakaryocyte progenitors to polyploidization inducers may be a major determinant of the exponential shape of NbD distributions. [less ▲]

Pharma-clinics comment je traite ... une infection par le VIH. IV. Les inhibiteurs de protease

in Revue Médicale de Liège (2001), 56(11), 739-44

Protease inhibitors constitute the last class of antiretroviral drugs appeared on the market. They raised an enormous enthusiasm, reinforced by recent studies results. These molecules prevent the ... [more ▼]

Protease inhibitors constitute the last class of antiretroviral drugs appeared on the market. They raised an enormous enthusiasm, reinforced by recent studies results. These molecules prevent the formation of infectious viral particles, while inhibiting a viral enzyme that plays a key role in the cycle of replication of the HIV. Their efficiency, especially in association, is recognized for all stages of the infection and the intervening of a resistance often requires many mutations. However, the unexpected adverse events such as lipodystrophy and some interactions can limit their utilization in first intention. [less ▲]

Cassini UVIS Observations of Jupiter's Auroral Variability

Poster (2001, October 27)

In the December 2000 Cassini flyby of the Jupiter system, the Cassini Ultraviolet Imaging Spectrograph (UVIS) monitored Jupiter's auroral emissions from day 275 of 2000 to day 81 of 2001. Much of the ... [more ▼]

In the December 2000 Cassini flyby of the Jupiter system, the Cassini Ultraviolet Imaging Spectrograph (UVIS) monitored Jupiter's auroral emissions from day 275 of 2000 to day 81 of 2001. Much of the auroral variability can be explained simply in terms of the rotation of Jupiter's auroral arcs (measured by Hubble Space Telescope) with the planet. However, several brightening events were seen in which the global auroral output increased by a factor of 2-4. These events persisted over a number of hours and are tied to large solar coronal mass ejection events. The auroral UV emissions from these bursts also correspond to hectometric radio emission increases reported by the Galileo and Cassini Radio and Plasma Wave experiments. The 2 largest events were on 2000 day 280 and on 2000 day 325-326. We will look at these events in some detail, and compare them with corresponding information on the interplanetary magnetic field, solar wind conditions, and energetic particle environment to try to understand the cause of these auroral brightness increases. [less ▲]

Enrichissement en PUFA oméga 3 et CLA des produits des porcs et des volailles: mythe ou réalité.

Conference given outside the academic context (2001)

Comparative joint imaging in smalls animals

Conference (2001, October 25)

Evidence-Based Medicine

Learning material (2001)

Dispenses de permis d'urbanisme en Région wallonne

in Immobilier (2001), 18

Mutations urbaines et développement durable : les surcoûts de la désurbanisation

Conference given outside the academic context (2001)

Effects on in vitro and in vivo cellular invasion of two 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives

Poster (2001, October 16)