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See detailVoxel-based distribution of metabolic impairment in corticobasal degeneration
Garraux, Gaëtan ULg; Salmon, Eric ULg; Peigneux, Philippe ULg et al

in Movement Disorders (2000), 15(5), 894-904

This report emphasizes the precise topographic distribution of cerebral metabolic impairment in corticobasal degeneration (CBD) and the pathophysiological differences between CBD and progressive ... [more ▼]

This report emphasizes the precise topographic distribution of cerebral metabolic impairment in corticobasal degeneration (CBD) and the pathophysiological differences between CBD and progressive supranuclear palsy (PSP). Statistical parametric mapping (SPM96) analysis of 18FDG positron emission tomography (PET) data was performed in 22 patients with CBD compared with 46 healthy subjects (HS) and 21 patients with PSP who were studied at rest. A statistical threshold of p <0.001 was fixed, further corrected for multiple or independent comparisons (p <0.05). In comparison with HS, the metabolic impairment in CBD was asymmetrically distributed in the putamen, thalamus, precentral (Brodmann's area, BA 4), lateral premotor (BA 6/44) and supplementary motor areas (SMA, BA 6), dorsolateral prefrontal (8/9/46) cortex, and the anterior part of the inferior parietal lobe (BA 40) including the intraparietal sulcus (BA 7/40). A similar hypometabolic pattern was observed for most individual analyses. When PSP was compared with CBD, metabolic impairment predominated in the midbrain, anterior cingulate (BA 24/32), and orbitofrontal regions (BA 10). The reverse contrast showed more posterior involvement in CBD (BA 6 and 5/7/40) including SMA. Our data suggest that multiple components of neural networks related to both movement execution and production of skilled movements are functionally disturbed in CBD compared with both HS and PSP. [less ▲]

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See detailAn agent-inspired active network resource trading model applied to congestion control
Yamamoto, Lidia; Leduc, Guy ULg

in Lecture Notes in Computer Science (2000, September), 1931

In order to accommodate fluctuations in network conditions, adaptive applications need to obtain information about resource availability, Using active networks, new models for adaptive applications can be ... [more ▼]

In order to accommodate fluctuations in network conditions, adaptive applications need to obtain information about resource availability, Using active networks, new models for adaptive applications can be envisaged, which can benefit from the possibility to send mobile code to the network nodes. We describe a model for trading resources inside an active net-work node, based on the interaction between capsules as reactive user agents, and resource manager agents which reside in the network nodes. We apply the model to the case of a many-to-one audio application with congestion control, which trades off link resources against memory when there is congestion at the outgoing interface towards the destination. Our simulation results indicate that the application makes effective use of the available resources, and it also allows resources to be shared according to user preferences. [less ▲]

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See detailCombined Suicide and Cytokine Gene Therapy for Peritoneal Carcinomatosis
Lechanteur, Chantal ULg; Delvenne, Philippe ULg; Princen, Frédéric et al

in Gut (2000), 47(3), 343-8

BACKGROUND: Gene therapy is a novel approach for the treatment of cancers, and tumours disseminated in the peritoneal cavity are suitable for in situ delivery of a therapeutic gene. AIMS: The efficacy of ... [more ▼]

BACKGROUND: Gene therapy is a novel approach for the treatment of cancers, and tumours disseminated in the peritoneal cavity are suitable for in situ delivery of a therapeutic gene. AIMS: The efficacy of a therapy combining a suicide gene (herpes simplex virus type I thymidine kinase (HSV-TK)) and cytokine genes was investigated in a model of peritoneal carcinomatosis induced by colon carcinoma cells in syngeneic rats. MATERIAL AND METHODS: Pre-established macroscopic tumours in BDIX rats were treated by intraperitoneal injections of retrovirus producing cells (FLYA13 TK, FLYA13 granulocyte macrophage-colony stimulating factor (GM-CSF), FLYA13 interleukin 12 (IL-12)) and ganciclovir (GCV). RESULTS: TK/GCV treated animals showed a slight increase in survival time (72 days) compared with the control group (63 days) while the association of cytokine and TK/GCV gene therapy resulted in significantly improved survival, with a large proportion of animals remaining tumour free on day 480 (60% and 40% for TK/GCV/GM-CSF and TK/GCV/IL-12 treated animals, respectively). Histological analysis of treated animals showed that the remaining tumour nodes were infiltrated by mononuclear cells but no major differences were observed between the various treatments. Immunohistochemical analysis revealed that lymphoid CD4(+) and CD8(+) T cells as well as macrophages accumulated outside untreated tumour nodes while CD8(+) and CD25(+) activated T cells and macrophages heavily infiltrated the tumours after the different treatments. CONCLUSIONS: Our data indicate that combined suicide and cytokine gene therapy is a powerful approach for the treatment of macroscopic peritoneal carcinomatosis. [less ▲]

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See detailLes aéroports wallons
Thiry, Bernard ULg; Charlier, J.; Delepiere, Ch. et al

Report (2000)

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See detailTransport ferroviaire à grande vitesse - Les passagers
Gathon, Henry-Jean ULg; Thiry, Bernard ULg; Charlier, J. et al

Report (2000)

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See detailLa gestion environnementale des aéroports
Charlier, J.; Delepiere, Ch.; Marchal, Jean ULg et al

Report (2000)

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See detailPrevention of neonatal group B streptococcal disease in Belgium: hospital policy, obstetricians' practice and laboratory processing
MELIN, Pierrette ULg; Schmitz, Myriam; Heinrichs, I. et al

in American Society of Microbiology (Ed.) Program and Abstracts of the 40th Intersciences Conference on Antimicrobial Agents and Chemotherapy (2000, September)

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See detailInv(12)(Q15q24): A Nonrandom Change Associated with Myelodysplasia?
Scantamburlo, Gabrielle ULg; Lampertz, serge; Jamar, Michelle ULg et al

in Cancer Genetics & Cytogenetics (2000), 121(2), 206-7

A patient with refractory anemia and a paracentric inversion of chromosome 12, inv(12)(q15q24), is described. This is the second reported case with this chromosome anomaly, suggesting that this ... [more ▼]

A patient with refractory anemia and a paracentric inversion of chromosome 12, inv(12)(q15q24), is described. This is the second reported case with this chromosome anomaly, suggesting that this rearrangement is a rare but nonrandom change associated with myelodysplastic syndromes. [less ▲]

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See detailDe consensus en blocus. La gestion des spécificités nationales, linguistiques et culturelles dans les évaluations internationales de la lecture
Baye, Ariane ULg

Master of advanced studies dissertation (2000)

This paper examines how was managed the linguistic and cultural diversity of participating countries in international reading assessment, from the first IEA reading and literature surveys to the PISA 2000 ... [more ▼]

This paper examines how was managed the linguistic and cultural diversity of participating countries in international reading assessment, from the first IEA reading and literature surveys to the PISA 2000 OECD project. [less ▲]

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See detailL'écriture en chantier
Baye, Ariane ULg; Denooz, Régine

Learning material (2000)

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See detailRapid intrapartum test (Strep B OIA) and prenatal cultures for identification of group B streptococcal carriers at delivery: a prospective study
MELIN, Pierrette ULg; Schmitz, Myriam; Tsobo, Chantal et al

in AAmerican Society of Microbiology (Ed.) Program and Abstracts of the 40th Intersciences Conference on Antimicrobial Agents and Chemotherapy (2000, September)

Background: The efficacy of the prenatal screening-based approach recommended by the CDC to prevent neonatal GBS diseases could be improved by using a good rapid test performed at the onset of labor. To ... [more ▼]

Background: The efficacy of the prenatal screening-based approach recommended by the CDC to prevent neonatal GBS diseases could be improved by using a good rapid test performed at the onset of labor. To assess the Strep B OIA® test (Biostar, Boulder, Co), completed in 30 minutes, we initiated a 6-center study to compare it with prenatal screening cultures to identify GBS carriers at delivery or opportunities to initiate intrapartum antibioprophylaxis (IAP). Methods: For a total of 539 pregnant women included in the study, pairs of vaginal/anal specimens collected at 35-37 weeks and intrapartum vaginal specimens were plated onto colistin-nalidixic agar and then inoculated into selective LIM broth for the detection of GBS. Furthermore, on each intrapartum vaginal swab a Strep B OIA test was performed. Results: GBS were recovered in culture from 89 prenatal screenings (17%) and from 71 specimens collected at delivery (13%). Strep B OIA test identified 48 positive specimens (9%). Respectively, for the identification of GBS carriers at delivery, sensitivity, specificity, positive and negative predictive values for prenatal screening cultures were 69%, 91%, 55% and 95% and for Strep B OIA tests they were 63%, 99%, 94% and 95%. Evaluating opportunities to start an IAP, based on Strep OIA test versus prenatal screening cultures, 45 IAP vs. 49 would have been useful, 3 vs. 40 useless (P< 0,001) and 26 vs. 22 missed. Conclusion: To identify GBS carriers, the Strep B OIA test, performed at the time of onset of labor is equally sensitive to prenatal screening cultures and would allow a highly significant reduction of useless IAP. [less ▲]

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See detailRatio of pyoverdines and dihydropyoverdines produced by Pseudomonas putida. BTP16 is influenced by the growth rate of the strain.
Jacques, Ph.; Ongena, Marc ULg; Bernard, F. et al

Poster (2000, September)

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See detailStudy of lipase production by yeast Yarrowia lipolytica
Fickers, P.; Destain, Jacqueline ULg; Thonart, Philippe ULg

Poster (2000, September)

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See detailChemical characterization of Yarrowia lipolytica extracellular lipase.
Destain, Jacqueline ULg; Moreau, B.; Fickers, P. et al

Poster (2000, September)

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See detailH NMR investigations on water dynamics during starch gels retrogradation.
Burtea, C.; Roch, A.; Pierart, Céline ULg et al

in Magnetic Resonance Materials in Biology, Physics and Medicine (2000), 11(Suppl. 1),

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See detailDifferential Functionalities of Amphiphilic Peptide Segments of the Cell-Septation Penicillin-Binding Protein 3 of Escherichia Coli
Marrec-Fairley, Monique; Piette, André ULg; Gallet, Xavier et al

in Molecular Microbiology (2000), 37(5), 1019-1031

The class B M1-V577 penicillin-binding protein (PBP) 3 of Escherichia coli consists of a M1-L39 membrane anchor (bearing a cytosolic tail) that is linked via a G40-S70 intervening peptide to an R71-I236 ... [more ▼]

The class B M1-V577 penicillin-binding protein (PBP) 3 of Escherichia coli consists of a M1-L39 membrane anchor (bearing a cytosolic tail) that is linked via a G40-S70 intervening peptide to an R71-I236 non-catalytic module (containing the conserved motifs 1-3) itself linked via motif 4 to a D237-V577 catalytic module (containing the conserved motifs 5-7 of the penicilloyl serine transferases superfamily). It has been proposed that during cell septation the peptidoglycan crosslinking activity of the acyl transferase module of PBP3 is regulated by the associated M1-I236 polypeptide itself in interaction with other components of the divisome. The fold adopted by the R71-V577 polypeptide of PBP3 has been modelled by reference to the corresponding R76-S634 polypeptide of the class B Streptococcus pneumoniae PBP2x. Based on these data and the results of site-directed mutagenesis of motifs 1-3 and of peptide segments of high amphiphilicity (identified from hydrophobic moment plots), the M1-I236 polypeptide of PBP3 appears to be precisely designed to work in the way proposed. The membrane anchor and the G40-S70 sequence (containing the G57-Q66 peptide segment) upstream from the non-catalytic module have the information ensuring that PBP3 undergoes proper insertion within the divisome at the cell septation site. Motif 1 and the I74-L82 overlapping peptide segment, motif 2 and the H160-G172 overlapping peptide segment, and the G188-D197 motif 3 are located at or close to the intermodule junction. They contain the information ensuring that PBP3 folds correctly and the acyl transferase catalytic centre adopts the active configuration. The E206-V217 peptide segment is exposed at the surface of the non-catalytic module. It has the information ensuring that PBP3 fulfils its cell septation activity within the fully complemented divisome. [less ▲]

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See detailMelatonine. II. Actions physiologiques et therapeutiques
Bruls, E.; Crasson, Marion ULg; Van Reeth, O. et al

in Revue Médicale de Liège (2000), 55(9), 862-70

Melatonin is a hormone mainly secreted by the pineal gland during the dark phase of the light-dark cycle. The most known function of melatonin in mammals is to transmit information concerning light-dark ... [more ▼]

Melatonin is a hormone mainly secreted by the pineal gland during the dark phase of the light-dark cycle. The most known function of melatonin in mammals is to transmit information concerning light-dark cycles playing the role of an active neuroendocrine transducer of environmental information. Given this chronobiologic role of pineal melatonin, it seems to be useful in the management of shift work, jet lag and some sleep disorders. In vitro like in vivo melatonin seems to be effective as an antioxidant and oncostatic agent. Melatonin may provide protection against aging process, degenerative diseases, cancer and play a role also in sexual maturation, reproduction, immune function and psychiatric illness. The administration of melatonin in the jet-lag syndrome is well codified. Further clinical research is needed for a better understanding and definition of other indications, treatment regimens and safety of the hormone. The aim of this paper is to review the current knowledge on its clinical implications. [less ▲]

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See detailEstradiol Pharmacokinetics after Transdermal Application of Patches to Postmenopausal Women: Matrix Versus Reservoir Patches
Reginster, Jean-Yves ULg; Donazzolo, Y.; Brion, N. et al

in Climacteric : The Journal of the International Menopause Society (2000), 3(3), 168-75

OBJECTIVE: A new matrix 17 beta-estradiol transdermal patch incorporating lauric acid to improve estradiol skin absorption has been designed for hormone replacement therapy. Estradiol pharmacokinetics ... [more ▼]

OBJECTIVE: A new matrix 17 beta-estradiol transdermal patch incorporating lauric acid to improve estradiol skin absorption has been designed for hormone replacement therapy. Estradiol pharmacokinetics obtained with the prototype, its industrial counterpart, a matrix-type, System 50, and a reservoir-type, Estraderm TTS 50, transdermal patch have been compared. Each device delivers 50 micrograms estradiol daily. METHODS: Twenty postmenopausal women received each of the four formulations for 3 days in a Latin-square design and with a minimum 4-day wash-out period between treatments. Estradiol plasma concentrations were measured by radioimmunoassay at 6, 12, 24, 48 and 72 h after application. RESULTS: The prototype patch and its industrial counterpart showed no significant difference in estradiol delivery, with 72-h systemic exposure to estradiol similar to that of the reservoir patch but greater than that of the reference matrix formulation, with average baseline-corrected concentrations (SEM) of 35 (4), 32 (3), 32 (2) and 19 (1.8) pg/ml, respectively. In addition, they ensured more stable delivery, with coefficients of variation of plasma estradiol concentrations (12-72 h) of 29, 41, 63 and 84%, respectively. All matrix patches demonstrated the same patients to be poor estradiol absorbers, different from those encountered with the reservoir patch type, despite an improved estradiol bioavailability with the lauric acid-containing matrix patch. CONCLUSION: Matrix patches incorporating lauric acid led to estradiol plasma levels more stable than with the reference matrix and reservoir patches, and greater than those with the reference matrix patch. [less ▲]

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