Marqueurs cardiaques: stratégie d'utilisation et d'interprétationChapelle, Jean-Paul ; Legrand, Victor ![]() Conference (2000, October) Detailed reference viewed: 3 (0 ULg) Alimentation et modifications de la composition en acides gras des graisses corporelles des porcs et des volailles.Thewis, André ; Conference given outside the academic context (2000) Detailed reference viewed: 8 (2 ULg) Lack of Association between Adult Asthma and the Tumour Necrosis Factor Alpha-308 Polymorphism GeneLouis, Renaud ; ; Malaise, Michel et alin European Respiratory Journal (2000), 16(4), 604-8 Tumour necrosis factor (TNF)alpha is a cytokine endowed with potent inflammatory properties that may contribute to airway inflammation in asthma. It has previously been shown that the single base pair ... [more ▼] Tumour necrosis factor (TNF)alpha is a cytokine endowed with potent inflammatory properties that may contribute to airway inflammation in asthma. It has previously been shown that the single base pair polymorphism-308 (G to A substitution) in the promoter of TNFalpha gene results in enhanced cytokine secretion. Whether this polymorphism is associated with the presence of phenotypic expression of asthma is questioned. In this study the relative frequency of TNF1 and TNF2 alleles in a population of adult healthy subjects (n=98) and adult Caucasian asthmatics (n=95) was compared taking into account their disease severity, atopic status and their smoking habit. For the whole group of asthma the genotype frequency for 1/1, 1/2, 2/2 were 67%, 33% and 0%, respectively, and not significantly different from those found in the control group that reached 70%, 28% and 2% respectively (p>0.05). The allele frequencies in asthma were 86% and 14% for TNF1 and TNF2 respectively while the corresponding figures were 85% and 15% in the control group (p>0.05). Furthermore, subdividing asthmatics into severe forced expiratory volume in one second <60% pred), atopic or smoking patients did not show any significant association with this TNFalpha polymorphism. To conclude the polymorphism -308 in the promoter of the TNFalpha gene does not confer a susceptibility to develop asthma nor to grade its severity. [less ▲] Detailed reference viewed: 16 (1 ULg) Combinatorial optimization approaches to the design of load shedding schemes against voltage instability; ; Van Cutsem, Thierry ![]() (2000, October) This paper proposes a methodology for the design of automatic load shedding against long-term voltage instability. In a first step, a set of training scenarios is set up, corresponding to various ... [more ▼] This paper proposes a methodology for the design of automatic load shedding against long-term voltage instability. In a first step, a set of training scenarios is set up, corresponding to various operating conditions and disturbances. Each scenario is analyzed to determine the minimal load shedding which stabilizes the system, with due consideration for the shedding location and delay. In a second step, the parameters of a closed-loop undervoltage load shedding scheme are determined so as to: (i) approach as closely as possible the optimal sheddings computed in the first step, over the whole set of scenarios; (ii) stabilize the system in all the unstable scenarios and (iii) shed no load in the stable ones. The corresponding optimization problem is solved using three methods : genetic algorithms, branch and bound approach and the so-called “sequential design”. A detailed example is given on the Hydro-Qu´ebec system in which load shedding is presently planned. [less ▲] Detailed reference viewed: 35 (5 ULg) Obésité et hypertension artérielle: de la physiopathologie au traitement; Krzesinski, Jean-Marie ![]() in Revue Médicale de Liège (2000), 55(10), 921-928 Obesity constitutes a problem of major concern in our industrialized countries. Overweight is frequently associated with hypertension (50% of hypertensive subjects are obese and the prevalence of ... [more ▼] Obesity constitutes a problem of major concern in our industrialized countries. Overweight is frequently associated with hypertension (50% of hypertensive subjects are obese and the prevalence of hypertension in obese patients is twice that of the normal population). Both pathologies are major cardiovascular risk factors. This review aims at a better understanding of the relationship between hypertension and overweight and at giving to the clinicians simple and consistent guidelines to treat these two medical entities. [less ▲] Detailed reference viewed: 415 (1 ULg) Application of a Mixed Normal Mixture Model for the Estimation of Mastitis-Related ParametersDetilleux, Johann ; in Journal of Dairy Science (2000), 83(10), 2341-9 The current methodology for estimating genetic parameters for SCC (SCS) does not account for the difference in SCS between healthy cows and cows with an intramammary infection (IMI). We propose a two ... [more ▼] The current methodology for estimating genetic parameters for SCC (SCS) does not account for the difference in SCS between healthy cows and cows with an intramammary infection (IMI). We propose a two-component finite mixed normal mixture model to estimate IMI prevalence, separate SCS subpopulation means, individual posterior probabilities of IMI, and SCS variance components. The theory is presented and the expectation-conditional maximization algorithm is utilized to compute maximum likelihood estimates. The methodology is illustrated on two simulated data sets based on the current knowledge of SCS parameters. Maximum likelihood estimates of IMI prevalence and SCS subpopulation means were close to simulated values, except for the estimate of IMI prevalence when both subpopulations were almost confounded. Individual posterior probabilities of IMI were always higher among infected than among healthy cows. Error and additive variance components obtained under the mixture model were closer to simulated values than restricted maximum likelihood estimates obtained assuming a homogeneous SCS distribution, especially when subpopulations were completely separated and when mixing proportion was highest. Convergence was linear and rapid when priors were chosen with caution. The advantages of the methodology are demonstrated, and its feasibility for large data sets is discussed. [less ▲] Detailed reference viewed: 15 (4 ULg) Surface structure of thin film blends of polystyrene and poly(n-butyl methacrylate); Jérôme, Robert ; et alin Colloid and Polymer Science (2000), 278(10), 993-999 Thin films of blends of polystyrene (PS) and poly(n-butyl methacrylate) (PBMA) were prepared by spin-casting onto silicon wafers in order to map the lateral distribution of the two polymers. The surfaces ... [more ▼] Thin films of blends of polystyrene (PS) and poly(n-butyl methacrylate) (PBMA) were prepared by spin-casting onto silicon wafers in order to map the lateral distribution of the two polymers. The surfaces were examined by atomic force microscopy (AFM) secondary ion mass spectroscopy X-ray photoelectron spectroscopy (XPS) and photoemission electron microscopy (PEEM). Films with PBMA contents of 50% w/w or less were relatively smooth, but further increase in the PBMA content produced, initially, protruding PS ribbons and then, for PBMA ≥80% w/w, isolated PS islands. At all concentrations the topmost surface (0.5-1.0 nm) was covered by PBMA, whilst the PBMA concentration in the near-surface region, measured by XPS, increased with bulk content to eventual saturation. PEEM measurements of a PS-PBMA film at the composition at which ribbon features were observed by AFM also showed a PS-rich ribbon structure surrounded by a sea of mainly PBMA. [less ▲] Detailed reference viewed: 53 (4 ULg) Un ordonnanceur assurant des services différenciés relatifs basés sur le délai; Leduc, Guy ; in Courtiat, Jean-Pierre; Diaz, Michel; Sénac, Patrick (Eds.) Qualité de Service, multimédia et mobilité (2000, October) Nous proposons l'ordonnanceur RD-VC garantissant des services différenciés (DiffServ) relativement quantifiés basés sur le délai. Un tel ordonnanceur assure que différentes classes de service obtiennent ... [more ▼] Nous proposons l'ordonnanceur RD-VC garantissant des services différenciés (DiffServ) relativement quantifiés basés sur le délai. Un tel ordonnanceur assure que différentes classes de service obtiennent des délais inversement proportionnels à des indices de qualité fixés, quelle que soit la charge du réseau, et sans signalisation, ni contrôle d'admission. De plus, bien que cet algorithme ne s'applique qu'aux classes de services, les délais relatifs sont également respectés pour chaque flux composant ces agrégats. Ceci permet d'assurer des qualités de service au niveau des (micro)flux sans que leur grand nombre ne conduise à un effondrement du système. L'algorithme offre de bonnes performances tout en étant très peu coûteux : le traitement par paquet est très léger et il n'est même pas nécessaire de disposer d'une file d'attente par classe de service. [less ▲] Detailed reference viewed: 14 (2 ULg) "II: La langue"Defays, Jean-Marc ![]() Conference given outside the academic context (2000) Detailed reference viewed: 4 (1 ULg)![]() La chirurgie du thymus, normal, involue ou tumoralLimet, Raymond ; Rogister, Bernard ![]() in Revue Médicale de Liège (2000), 55(10), 940-4 Thymoma is the most frequently resected mediastinal tumor. Its malignancy is related more to macroscopical findings than to microscopical analysis. All thymomas should be resected, in order to prevent ... [more ▼] Thymoma is the most frequently resected mediastinal tumor. Its malignancy is related more to macroscopical findings than to microscopical analysis. All thymomas should be resected, in order to prevent malignant degeneration. Furthermore, for the treatment of myasthenia, several centers recommend resection of the thymus, either tumoral (thymoma) or atrophied. Although the role of surgery in this regard is controversial, all authors unanimously stress that complete resection of all thymic remnants is essential to achieve adequate results. [less ▲] Detailed reference viewed: 33 (3 ULg) La jurisprudence de la Cour d'arbitrageBourgeois, Marc ![]() Conference (2000, October) Detailed reference viewed: 8 (1 ULg) Voyage au pays de Darius et des ayattolahsNazé, Yaël ; Article for general public (2000) Detailed reference viewed: 16 (0 ULg) Les Troyens à Métaponte. Etude d'une nouvelle Ilioupersis de la céramique italiote.Morard, Thomas ![]() Master's dissertation (2000) Detailed reference viewed: 24 (1 ULg) Far ultraviolet imaging of the aurora: new directions; ; et al Conference (2000, October) Detailed reference viewed: 1 (0 ULg)![]() Cephalees explosives, "en coup de tonnerre": faut-il s'inquieter?DELVAUX, Valérie ; ; Schoenen, Jean ![]() in Revue Médicale de Liège (2000), 55(10), 910914 "Thunderclap" headaches are explosive, extremely intense and sometimes associated with neurological signs or symptoms. As illustrated by the 3 case histories presented here, they are a heterogenous group ... [more ▼] "Thunderclap" headaches are explosive, extremely intense and sometimes associated with neurological signs or symptoms. As illustrated by the 3 case histories presented here, they are a heterogenous group as far as etiology and prognosis are concerned. They may be symptomatic of an intracranial disorder (subarachnoid hemorrhage, cerebral venous thrombosis, pituitary apoplexia) or idiopathic without any known cause and with a benign, though occasionally recurring, course. They can be spontaneous or triggered by Valsalva maneuvers (cough, exertion, coitus, ...). In certain cases of so-called "idiopathic" thunderclap headache, diffuse, multifocal segmental and reversible vasospasm of cerebral arteries has been found on neuroimaging. As headache characteristics are similar in symptomatic and benign cases, angio-MRI is recommended when CT-scan and CSF examination are normal. [less ▲] Detailed reference viewed: 57 (1 ULg) Développement d'un modèle élasto-plastique pour une craie saturéeCollin, Frédéric ![]() Master of advanced studies dissertation (2000) Detailed reference viewed: 14 (4 ULg) New Functional Aliphatic Polyesters by Chemical Modification of Copolymers of ε-Caprolactone with γ-(2-Bromo-2-methylpropionate)- ε-caprolactone, γ-Bromo- ε-caprolactone, and a Mixture of β-and γ-Ene- ε-caprolactoneDetrembleur, Christophe ; ; et alin Macromolecules (2000), 33(17), 7751-7760 New functional aliphatic polyesters were prepared by chemical modification of brominated copolyesters. Poly(epsilon-caprolactone)-co-poly(gamma-(2-bromo-2-methylpropionate)-epsilon-caprolactone) copolymer ... [more ▼] New functional aliphatic polyesters were prepared by chemical modification of brominated copolyesters. Poly(epsilon-caprolactone)-co-poly(gamma-(2-bromo-2-methylpropionate)-epsilon-caprolactone) copolymer was prepared and successfully converted into copolyester bearing methacrylate double bonds by dehydrohalogenation of the pendant tertiary alkyl bromides, thus leading to cross-linkable polyester. The tertiary alkyl bromide groups of the original copolyester were also quaternized by reaction with pyridine, although some side reactions occurred which Limited the reaction yield. Nevertheless, quaternization of the bromide groups of the poly(epsilon-caprolactone)-co-poly(gamma-bromo-epsilon-caprolactone) copolymer proved to be quantitative and to occur without degradation of the polyester chains. This general strategy paves the way to either amphiphilic copolyesters or water-soluble polyesters. The poly(epsilon -caprolactone)-co-poly(gamma -bromo-epsilon-caprolactone) lactone) copolymer was also quantitatively converted into unsaturated copolyester by dehydrohalogenation with formation of double bonds including acrylic-type double bonds. As an alternative, gamma-bromo-epsilon-caprolactone was first dehydrohalogenated, and the unsaturated cyclic monomer was copolymerized with epsilon-caprolactone. Finally, the nonconjugated double bonds of the copolyesters were oxidized into epoxides, except for the acrylic-type unsaturations which remained unchanged. [less ▲] Detailed reference viewed: 40 (11 ULg)![]() Additive Effect between Nf-Kappab Subunits and P53 Protein for Transcriptional Activation of Human P53 Promoter; ; et al in Oncogene (2000), 19(41), 4787-94 The tumor suppressor p53 plays a pivotal role in the cellular response to DNA damage as it controls DNA repair, cell cycle arrest and apoptosis. We studied the autoregulation of human p53 gene ... [more ▼] The tumor suppressor p53 plays a pivotal role in the cellular response to DNA damage as it controls DNA repair, cell cycle arrest and apoptosis. We studied the autoregulation of human p53 gene transcription in colon cancer cell lines. Wild-type p53 has been shown to autoregulate its own transcription either positively or negatively and probably in a cell-type-specific manner. Indeed, a p53 binding site has been described in the human and murine p53 promoters, but a direct binding of wild-type p53 protein to this site has never been reported. In this study, we demonstrated a transactivation of human p53 promoter by wild-type p53 in human colon cancer cells. We identified in the human p53 promoter a novel potential p53-responsive element that binds wild-type p53. Moreover, wild-type p53 protein transactivated a reporter plasmid containing a luciferase gene driven by a minimal promoter harboring this p53 binding site. Finally, as the p53 promoter contains an NF-kappaB binding site, we demonstrated an additive effect when NF-kappaB subunits and p53 protein combined to transactivate the human p53 promoter. [less ▲] Detailed reference viewed: 11 (0 ULg) |
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