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See detailOn the nature of the spectral and photometric periodic variability of apparently single Wolf-Rayet stars
Morel, Thierry ULg

in The Observatory (1999), 119

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See detailDeep Imaging of AX J2019+112: The Luminosity of a ``Dark Cluster''
Benítez, Narciso; Broadhurst, Tom; Rosati, Piero et al

in Astrophysical Journal (1999), 527

We detect a distant cluster of galaxies centered on the QSO lens and luminous X-ray source AX J2019+112, a.k.a. the ``Dark Cluster.'' Using deep V and I Keck images and wide-field K[SUB]s[/SUB] imaging ... [more ▼]

We detect a distant cluster of galaxies centered on the QSO lens and luminous X-ray source AX J2019+112, a.k.a. the ``Dark Cluster.'' Using deep V and I Keck images and wide-field K[SUB]s[/SUB] imaging from the New Technology Telescope (NTT), a tight red sequence of galaxies is identified within a radius of 0.2 h[SUP]-1[/SUP] Mpc of the known z=1.01 elliptical lensing galaxy. The sequence, which includes the central elliptical galaxy, has a slope in good agreement with the model predictions of Kodama et al. for z~1. We estimate the integrated rest-frame luminosity of the cluster to be L[SUB]V[/SUB]>=3.2x10[SUP]11[/SUP] h[SUP]-2[/SUP] L[SUB]solar[/SUB] (after accounting for significant extinction at the low latitude of this field), more than an order of magnitude higher than previous estimates. The central region of the cluster is deconvolved using the technique of Magain, Courbin, & Sohy, revealing a thick central arc coincident with an extended radio source. All the observed lensing features are readily explained by differential magnification of a radio-loud active galactic nucleus by a shallow elliptical potential. The QSO must lie just outside the diamond caustic, producing two images; the arc is a highly magnified image formed from a region close to the center of the host galaxy, projecting inside the caustic. The mass-to-light ratio within an aperture of 0.4 h[SUP]-1[/SUP] Mpc is M[SUB]X[/SUB]/L[SUB]V[/SUB]=224[SUP]+112[/SUP][SUB]- 78[/SUB]h(M/L[SUB]V[/SUB])[SUB]solar[/SUB], using the X-ray temperature. The strong lens model yields a compatible value, M/L[SUB]V[/SUB]=372[SUP]+94[/SUP][SUB]- 94[/SUB]h(M/L[SUB]V[/SUB])[SUB]solar[/SUB], whereas an independent weak-lensing analysis sets an upper limit of M/L[SUB]V[/SUB]<520h(M/L[SUB]V[/SUB])[SUB]solar[/SUB], typical of massive clusters. [less ▲]

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See detailThe self-enrichment of galactic halo globular clusters. A clue to their formation?
Parmentier, Geneviève ULg; Jehin, Emmanuel ULg; Magain, Pierre ULg et al

in Astronomy and Astrophysics (1999), 352

We present a model of globular cluster self-enrichment. In the protogalaxy, cold and dense clouds embedded in the hot protogalactic medium are assumed to be the progenitors of galactic halo globular ... [more ▼]

We present a model of globular cluster self-enrichment. In the protogalaxy, cold and dense clouds embedded in the hot protogalactic medium are assumed to be the progenitors of galactic halo globular clusters. The massive stars of a first generation of metal-free stars, born in the central areas of the proto-globular cluster clouds, explode as Type II supernovae. The associated blast waves trigger the expansion of a supershell, sweeping all the material of the cloud, and the heavy elements released by these massive stars enrich the supershell. A second generation of stars is born in these compressed and enriched layers of gas. These stars can recollapse and form a globular cluster. This work aims at revising the most often encountered argument against self-enrichment, namely the presumed ability of a small number of supernovae to disrupt a proto-globular cluster cloud. We describe a model of the dynamics of the supershell and of its progressive chemical enrichment. We show that the minimal mass of the primordial cluster cloud required to avoid disruption by several tens of Type II supernovae is compatible with the masses usually assumed for proto-globular cluster clouds. Furthermore, the corresponding self-enrichment level is in agreement with halo globular cluster metallicities. [less ▲]

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See detailThermal crosslinking of poly(methyl methacrylate) by reaction of methyl ester and quaternary ammonium salt and application to (meth)acrylate-based TPEs
Tong, Jiang-Dong; Goethals, Eric; Jérôme, Robert ULg

in Journal of Polymer Science. Part A, Polymer Chemistry (1999), 37(23), 4402-4411

Copolymers of N-vinylbenzyl N-methyl pyrrolidinium chloride (VBMPC) and methyl methacrylate, PVBMPC-co-poly(methyl methacrylate) (PMMA), were synthesized by free-radical copolymerization and proved to be ... [more ▼]

Copolymers of N-vinylbenzyl N-methyl pyrrolidinium chloride (VBMPC) and methyl methacrylate, PVBMPC-co-poly(methyl methacrylate) (PMMA), were synthesized by free-radical copolymerization and proved to be prone to crosslinking as a result of the reaction of methyl ester groups with benzyl methyl pyrrolidinium chloride (BMPC) moieties at temperatures higher than 110 °C. When the VBMPC content was lower than 20 wt %, these copolymers were miscible with homo-PMMA. Blends of homo-PMMA and PVBMPC-co-PMMA fully could be cured above 150 °C, when the molecular weight of PMMA exceeded 10,000 and the VBMPC content of the copolymer was higher than 5 wt %. This reaction was carried out to crosslink selectively the PMMA microdomains of PMMA-b-poly(isooctyl acrylate) (PIOA)-b-PMMA (MIM) triblock copolymers to explain the mechanism for the mechanical failure of fully (meth)acrylic thermoplastic elastomers. Comparison of the ultimate tensile properties of MIM block copolymers, when the dispersed PMMA phases and PIOA matrix were crosslinked, led to the conclusion that the ductile failure of the hard PMMA microdomains rather than the elastic failure of the PIOA matrix was the reason for the mechanical failure of MIM triblocks. [less ▲]

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See detailCabergoline in the treatment of hyperprolactinemia: a study in 455 patients.
Verhelst, Johan; Abs, Roger; Maiter, Dominique et al

in Journal of Clinical Endocrinology and Metabolism (1999), 84(7), 2518-22

Cabergoline is a new long-acting dopamine agonist that is very effective and well tolerated in patients with pathological hyperprolactinemia. The aim of this study was to examine, in a very large number ... [more ▼]

Cabergoline is a new long-acting dopamine agonist that is very effective and well tolerated in patients with pathological hyperprolactinemia. The aim of this study was to examine, in a very large number of hyperprolactinemic patients, the ability to normalize PRL levels with cabergoline, to determine the effective dose and tolerance, and to assess the effect on clinical symptoms, tumor shrinkage, and visual field abnormalities. We also evaluated the effects of cabergoline in a large subgroup of patients with bromocriptine intolerance or -resistance. We retrospectively reviewed the files of 455 patients (102 males and 353 females) with pathological hyperprolactinemia treated with cabergoline in 9 Belgian centers. Among these patients, 41% had a microadenoma; 42%, a macroadenoma; 16%, idiopathic hyperprolactinemia; and 1%, an empty sella. The median pretreatment serum PRL level was 124 microg/L (range, 16-26,250 microg/L). A subgroup of 292 patients had previously been treated with bromocriptine, of which 140 showed bromocriptine intolerance and 58 showed bromocriptine resistance. Treatment with cabergoline normalized serum PRL levels in 86% of all patients: in 92% of 244 patients with idiopathic hyperprolactinemia or a microprolactinoma and in 77% of 181 macroadenomas. Pretreatment visual field abnormalities normalized in 70% of patients, and tumor shrinkage was seen in 67% of cases. Side effects were noted in 13% of patients, but only 3.9% discontinued therapy because of side effects. The median dose of cabergoline at the start of therapy was 1.0 mg/week but could be reduced to 0.5 mg/week once control was achieved. Patients with a macroprolactinoma needed a higher median cabergoline dose, compared with those with idiopathic hyperprolactinemia or a microprolactinoma: 1.0 mg/week vs. 0.5 mg/week, although a large overlap existed between these groups. Twenty-seven women treated with cabergoline became pregnant, and 25 delivered a healthy child. One patient had an intended abortion and another a miscarriage. In the patients with bromocriptine intolerance, normalization of PRL was reached in 84% of cases, whereas in the bromocriptine-resistant patients, PRL could be normalized in 70%. We confirmed, in a large-scale retrospective study, the high efficacy and tolerability of cabergoline in the treatment of pathological hyperprolactinemia, leaving few patients with unacceptable side effects or inadequate clinical response. Patients with idiopathic hyperprolactinemia or a microprolactinoma, on average, needed only half the dose of cabergoline as those with macroprolactinomas and have a higher chance of obtaining PRL normalization. Cabergoline also normalized PRL in the majority of patients with known bromocriptine intolerance or -resistance. Once PRL secretion was adequately controlled, the dose of cabergoline could often be significantly decreased, which further reduced costs of therapy. [less ▲]

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See detailTribologie en oxygène liquide
Bozet, Jean-Luc ULg; Bozet, Jean-Luc ULg; Gras, R. et al

in Matériaux et techniques ”, SIRPE, numéro hors série, 38èmes Journées du cercle d’études des métaux (1999, December)

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See detailLa prévention des rechutes adictives
Kempeneers, Philippe ULg

in Revue Francophone de Clinique Comportementale et Cognitive (1999), 4(4), 24-34

Relapse prevention (RP) is a model of therapeutic intervention started in the field of substance abuses but applicable to all addictive behaviors. This papper first specifies the concept of addiction ... [more ▼]

Relapse prevention (RP) is a model of therapeutic intervention started in the field of substance abuses but applicable to all addictive behaviors. This papper first specifies the concept of addiction. Follows a description of the principles of RP concerning the relapse process and a specification of RP as a clinical and theorical model. Finally there is a more detailed presentation of several mechansisms characteristics of addictive relapses as well as the modes of treatment the RP offers [less ▲]

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See detailLearning subordinate and basic level category names : the misssing link
Thibaut, Jean-Pierre; Comblain, Annick ULg; Laurent, Marie et al

Poster (1999, December)

Chez les enfants normaux, l'acquisition du lexique est soumise à quatre principes de base acquis dans un ordre développemental déterminé : le principe de l'objet total, le principe d'extensibilité, le ... [more ▼]

Chez les enfants normaux, l'acquisition du lexique est soumise à quatre principes de base acquis dans un ordre développemental déterminé : le principe de l'objet total, le principe d'extensibilité, le principe taxinomique et le principe d'appariement d'un nouveau nom à une catégorie sans nom. Les enfants présentant un retard mental, du moins les enfants atteints des syndromes de Down et de Williams-Beuren) sont également soumis à l'application de ces principes lors de l'acquisition du lexique. Si le cadre de travail fourni par ces quatre principes d'acquisition du lexique permet de dégager des pistes d'intervention utilisables avec les jeunes enfants, des recherches sont encore nécessaires afin d'établir le type d'activités le plus efficace dans le cadre d'une stimulation lexicale chez l'enfant normal et à fortiori chez l'enfant atteint d'un retard mental. Il est primordial de garder à l'esprit que le but d'une intervention est d'optimaliser les bases cognitives et linguistiques sous-tendant un principe particulier et non d'enseigner à l'enfant une stratégie de surface ne faisant que mimer le principe (Mervis & Bertrand, 1993). [less ▲]

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See detailLa loi de protection du malade mental du 26 juin 1990. Présentation et jurisprudence
Boxho, Philippe ULg

in Journal des Juges de Paix = Tijdschrift van de Vrederecters (1999), 12

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See detailL’Optimisation Topologique en Mécanique
Duysinx, Pierre ULg

Article for general public (1999)

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See detailApplications biomédicales de la RPE
Hoebeke, Maryse ULg

Scientific conference (1999, December)

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See detailApplication of Supercritical Carbon Dioxide for the Preparation of a Piroxicam-Beta-Cyclodextrin Inclusion Compound
Van Hees, Thierry ULg; Piel, Géraldine ULg; Evrard, Brigitte ULg et al

in Pharmaceutical Research (1999), 16(12), 1864-70

PURPOSE: Piroxicam is a poorly soluble NSAID, whose solubility is enhanced when included into beta-cyclodextrin. The preparation of a piroxicam-beta-cyclodextrin inclusion compound using supercritical CO2 ... [more ▼]

PURPOSE: Piroxicam is a poorly soluble NSAID, whose solubility is enhanced when included into beta-cyclodextrin. The preparation of a piroxicam-beta-cyclodextrin inclusion compound using supercritical CO2 was investigated. METHODS: The solubility and the stability of piroxicam in supercritical CO2 were determined. Then, the influence of the temperature, the pressure and the time of exposure on the inclusion rate was studied. RESULTS: The solubility of piroxicam varied over a wide range depending on the temperature and pressure (from 0.006 to 1.500 mg/g of CO2). The temperature and the time of exposure had a great influence on the inclusion yield, while pressure did not and a complete inclusion was achieved by keeping a physical mixture of piroxicam and beta-cyclodextrin (1:2.5 mol/mol) for 6 hours at 150 degrees C and 15 MPa of CO2. This complex was characterized by Differential Scanning Calorimetry, differential solubility and Fourier Transform Infrared Spectrometry. CONCLUSIONS: Supercritical carbon dioxide may prove to be a novel useful complexation method of drugs into beta-cyclodextrin. [less ▲]

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See detailVimentin Contributes to Human Mammary Epithelial Cell Migration
Gilles, Christine ULg; Polette, M.; Zahm, J. M. et al

in Journal of Cell Science (1999), 112((Pt 24)), 4615-25

Vimentin expression in human mammary epithelial MCF10A cells was examined as a function of their migratory status using an in vitro wound-healing model. Analysis of the trajectories of the cells and their ... [more ▼]

Vimentin expression in human mammary epithelial MCF10A cells was examined as a function of their migratory status using an in vitro wound-healing model. Analysis of the trajectories of the cells and their migratory speeds by time lapse-video microscopy revealed that vimentin mRNA and protein expression were exclusively induced in cells at the wound's edge which were actively migrating towards the center of the lesion. Actin labeling showed the reorganization of actin filaments in cells at the wound's edge which confirmed the migratory phenotype of this cell subpopulation. Moreover, the vimentin protein disappeared when the cells became stationary after wound closure. Using cells transfected with the vimentin promoter controlling the green fluorescent protein gene, we also demonstrated the specific activation of the vimentin promoter in the migratory cells at the wound's edge. Transfection of the antisense vimentin cDNA into MCF10A cells clearly reduced both their ability to express vimentin and their migratory speed. Taken together, these observations demonstrate that vimentin is transiently associated with, and could be functionally involved in, the migratory status of human epithelial cells. [less ▲]

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See detailMice Transgenic for a Soluble Form of Murine Cytotoxic T Lymphocyte Antigen 4 Are Refractory to Murine Acquired Immune Deficiency Sydrome Development
de Leval, Laurence ULg; Debrus, S.; Lane, P. et al

in Immunology (1999), 98(4), 630-8

Interactions between B and CD4+ T cells are central to the pathogenesis of retrovirus-induced murine acquired immune deficiency virus (MAIDS). Prompted by previous work showing that treatment with ... [more ▼]

Interactions between B and CD4+ T cells are central to the pathogenesis of retrovirus-induced murine acquired immune deficiency virus (MAIDS). Prompted by previous work showing that treatment with cytotoxic T lymphocyte antigen 4 immunoglobulin (CTLA4Ig) partly inhibited the disease, we studied the course of infection in mice deficient for CD28-B7 interactions (mCTLA4-Hgamma1 transgenic mice). Despite a relative viral load identical to that of non-transgenic mice, the transgenic mice did not develop any of the major MAIDS symptoms (i.e. lymphoproliferation and immune anergy). The mCTLA4-Hgamma1 did not however, completely inhibit B-cell activation as indicated by a slight hypergammaglobulinaemia and microscopic blastic transformation. Absence of MAIDS in transgenic mice was associated with much lower levels of both interleukin-4 and interferon-gamma transcripts following viral infection. These results support the theory that the CD28/B7 costimulatory pathway is a critical determinant to MAIDS development. [less ▲]

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See detailCase Management in Belgium
Gosset, Christiane ULg; de Froidmont, C.

in Case Management in various national elderly assistance systems (1999)

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See detailAnalytic and clinical evaluation of the Abbott AxSYM cardiac troponin I assay
Elst, K. M. V.; Chapelle, Jean-Paul ULg; Boland, P. et al

in American Journal of Clinical Pathology (1999), 122(6), 745-752

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See detailTuteurs en ligne : quels rôles, quelle formation ?
Charlier, Bernadette; Docq, Françoise; Lebrun, Marcel et al

Learning material (1999)

The LEARN-NETT project aims at developing and promoting the use of ICT into and for teachers' training. In this way, groups composed by students from different european universities are supported by an ... [more ▼]

The LEARN-NETT project aims at developing and promoting the use of ICT into and for teachers' training. In this way, groups composed by students from different european universities are supported by an "on-line tutor" who helps them to communicate, collaborate and lead a reflection during collaborative project. This contribution presents and analyses the different roles of these tutors and proposes a model for an "on-line tutor" training. [less ▲]

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See detailThe homeodomain-containing proteins: an update on their interacting partners
Chariot, Alain ULg; Gielen, Jacques; Merville, Marie-Paule ULg et al

in Biochemical Pharmacology (1999), 58

Homeodomain-containing proteins are transcription regulators controlling the coordinated expression of genes involved in development, differentiation, and cellular transformation. They share a highly ... [more ▼]

Homeodomain-containing proteins are transcription regulators controlling the coordinated expression of genes involved in development, differentiation, and cellular transformation. They share a highly conserved 60-amino-acid region (the "homeodomain"), which allows them to bind DNA and modulate the expression of multiple target genes, whose identities remain largely unknown. Although each HOX gene product exhibits in vivo specificity, they harbor very similar DNA-binding affinities in vitro, suggesting that other mechanisms such as protein-protein interactions are critical to modulate their function. In this commentary, we describe the proteins that can interact with the HOX gene products, including newly identified partners such as CREB binding protein and the NF-kappaB/IkappaB-alpha proteins. We also outline the molecular programs that are regulated by the transcriptional complexes involving the HOX gene products and where new pharmacological tools could find interesting targets. [less ▲]

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See detailL'image du mois. Fermeture percutanée de la communication interauriculaire
Massin, M.; Legrand, Victor ULg; Materne, Pierre ULg et al

in Revue Médicale de Liège (1999), 54(12), 907-8

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