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See detailApplication of nuclear scintigraphy to evaluation of pulmonary function
Votion, Dominique ULg

in In Proceedings: 17th Comparative Respiratory Society Meeting (1999, October)

Nuclear imaging techniques have a long history in pulmonary medicine and the clinical and experimental uses of lung scintigraphy have largely expanded these last years. Currently, the pulmonary ... [more ▼]

Nuclear imaging techniques have a long history in pulmonary medicine and the clinical and experimental uses of lung scintigraphy have largely expanded these last years. Currently, the pulmonary applications of nuclear scintigraphy are essentially: (I), the study of regional lung function; (II), the imaging of pulmonary infection and/or inflammation; (III), the determination of inflammatory cells involvement in lung diseases; (IV), the assessment of the alveolar-capillary barrier integrity; (V), the imaging of lung cancers and (VI), the study of aerosol deposition within the lung. Many faculty of veterinary medicine have acquired nuclear imaging facilities. The primary application of scintigraphy is in the investigation of equine orthopaedic conditions and, with the exception of rodents, only a few publications report the use of lung scintigraphy in any animal species. Nevertheless, lung scintigraphy using animals would be of great interest to better understand the lung physiology in general as well as animals’ peculiarities in particular. Following a brief introduction to the technique, this paper will review the main applications of pulmonary scintigraphy and will survey some new nuclear imaging techniques that should be available in the next future. [less ▲]

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See detailPotential effects of NSAID on myocellular enzyme leakage and delayed onset muscle soreness induced by isokinetic eccentric exercise
Croisier, Jean-Louis ULg; Camus, Gérard; Crielaard, Jean-Michel ULg

in Actes du XIXe Congrès National de la Société Française de Médecine du Sport (1999, October)

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See detailUne analyse de discours spécifique : le média de masse
Servais, Christine ULg

Scientific conference (1999, October)

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See detailBrève sociologie de la littérature belge
Servais, Christine ULg

Scientific conference (1999, October)

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See detailReflux gastro-oesophagien et asthme
Lamproye, Anne ULg; Louis, Edouard ULg; Louis, Renaud ULg et al

in Revue Médicale de Liège (1999), 54(10), 805-8

Gastro-oesophageal reflux (GER) is more frequent in asthmatic patients than in the community at large. A causative association between the two diseases is suspected. Twenty-four hour ambulatory ... [more ▼]

Gastro-oesophageal reflux (GER) is more frequent in asthmatic patients than in the community at large. A causative association between the two diseases is suspected. Twenty-four hour ambulatory intraoesophageal pH monitoring represents the golden standard for the diagnosis of GER. The medical and/or surgical treatment of reflux in asthmatic patients with GER can improve pulmonary symptoms and to a lesser extent pulmonary function. The selection of the patients who will benefit from a GER treatment is difficult. Some symptoms like intrinsic asthma, nocturnal crises, could predict a good response to GER treatment. [less ▲]

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See detailPharma clinics. Le médicament du mois. La lercanidipine (Zanidip)
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1999), 54(10), 832-834

Lercanidipine (Zanidip) is a new calcium antagonist belonging to the dihydropyridine family suitable for the first-line treatment of hypertension. This molecule displays a high specificity and selectivity ... [more ▼]

Lercanidipine (Zanidip) is a new calcium antagonist belonging to the dihydropyridine family suitable for the first-line treatment of hypertension. This molecule displays a high specificity and selectivity for vascular smooth muscle cells and has, in spite of a short plasma half-life, a long duration of action due to its liposolubility. The usual and once a day dose to treat high blood pressure of any grade is 10 mg, which if needed could be increased to 20 mg once a day. It has a gradual onset of effect on blood pressure, thus leading to a good tolerability and hopefully a better compliance in the treatment of hypertension. No adaptation of the dose is needed in older patients or in patients with moderate renal or liver impairment. [less ▲]

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See detailA general framework for power system transient stability control
Pavella, Mania ULg; Ernst, Damien ULg; Ruiz-Vega, Daniel

in IEEE Power Engineering Society Letters (1999), 19(10), 45-46

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See detailSymposium Acromegaly : Current treatment modalities and pre-surgical approaches of acromegaly
Beckers, Albert ULg

Scientific conference (1999, October)

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See detailKinetics modelling of convective heat drying of wastewater treatment sludge
Léonard, Angélique ULg; Salmon, Thierry ULg; Janssens et al

in Flamand, G. (Ed.) Récents progrés en génie des procédés vol.13 n.68 : separations. ECCE 2 conference Montpellier 5/7.10.99 (1999, October)

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See detailCharacterization of nonlinear aeroservoelastic behaviour
Dimitriadis, Grigorios ULg; Cooper, Jonathan Edware

in RTO-MP-036 Structural Aspects of Flexible Aircraft Control (1999, October)

The characterisation of the behaviour of nonlinear aeroelastic systems has become a very important re- search topic. Nevertheless, most of the work carried out to date concerns the development of unsteady ... [more ▼]

The characterisation of the behaviour of nonlinear aeroelastic systems has become a very important re- search topic. Nevertheless, most of the work carried out to date concerns the development of unsteady CFD solutions in the transonic region. Important though this work is, there is also a need for research which aims at understanding the behaviour of non- linear systems, particularly the occurance of Limit Cycle Oscillations (LCOs). The purpose of this pa- per is to study the stability of a simple aeroservoelas- tic system with nonlinearities in the control system. The work considers both structural and control law nonlinearities and assesses the stability of the system response by use of bifurcation diagrams. It is shown that simple feedback systems designed to increase the stability of the linearised system also stabilise the nonlinear system, although their effects can be less pronounced. Additionally, a nonlinear control law designed to limit the control surface pitch response was found to increase the flutter speed considerably by forcing the system to undergo limit cycle oscilla- tions instead of fluttering. Finally, friction was found to affect the damping of the system but not its sta- bility, as long as the amplitude of the frictional force is low enough not to cause stoppages in the motion. [less ▲]

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See detailEtude des causes de la ruine du Bateau Ave Maria,
Rigo, Philippe ULg

Report (1999)

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See detailThe Catalytic, Glycosyl Transferase and Acyl Transferase Modules of the Cell Wall Peptidoglycan-Polymerizing Penicillin-Binding Protein 1b of Escherichia Coli
Terrak, Mohammed ULg; Ghosh, Tushar K.; van Heijenoort, Jean et al

in Molecular Microbiology (1999), 34(2), 350-364

The penicillin-binding protein (PBP) 1b of Escherichia coli catalyses the assembly of lipid-transported N-acetyl glucosaminyl-beta-1, 4-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-(L)-meso-diaminopimelyl ... [more ▼]

The penicillin-binding protein (PBP) 1b of Escherichia coli catalyses the assembly of lipid-transported N-acetyl glucosaminyl-beta-1, 4-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-(L)-meso-diaminopimelyl+ ++- (L)-D-alanyl-D-alanine disaccharide pentapeptide units into polymeric peptidoglycan. These units are phosphodiester linked, at C1 of muramic acid, to a C55 undecaprenyl carrier. PBP1b has been purified in the form of His tag (M46-N844) PBP1bgamma. This derivative provides the host cell in which it is produced with a functional wall peptidoglycan. His tag (M46-N844) PBP1bgamma possesses an amino-terminal hydrophobic segment, which serves as transmembrane spanner of the native PBP. This segment is linked, via an congruent with 100-amino-acid insert, to a D198-G435 glycosyl transferase module that possesses the five motifs characteristic of the PBPs of class A. In in vitro assays, the glycosyl transferase of the PBP catalyses the synthesis of linear glycan chains from the lipid carrier with an efficiency of congruent with 39 000 M-1 s-1. Glu-233, of motif 1, is central to the catalysed reaction. It is proposed that the Glu-233 gamma-COOH donates its proton to the oxygen atom of the scissile phosphoester bond of the lipid carrier, leading to the formation of an oxocarbonium cation, which then undergoes attack by the 4-OH group of a nucleophile N-acetylglucosamine. Asp-234 of motif 1 or Glu-290 of motif 3 could be involved in the stabilization of the oxocarbonium cation and the activation of the 4-OH group of the N-acetylglucosamine. In turn, Tyr-310 of motif 4 is an important component of the amino acid sequence-folding information. The glycosyl transferase module of PBP1b, the lysozymes and the lytic transglycosylase Slt70 have much the same catalytic machinery. They might be members of the same superfamily. The glycosyl transferase module is linked, via a short junction site, to the amino end of a Q447-N844 acyl transferase module, which possesses the catalytic centre-defining motifs of the penicilloyl serine transferases superfamily. In in vitro assays with the lipid precursor and in the presence of penicillin at concentrations sufficient to derivatize the active-site serine 510 of the acyl transferase, the rate of glycan chain synthesis is unmodified, showing that the functioning of the glycosyl transferase is acyl transferase independent. In the absence of penicillin, the products of the Ser-510-assisted double-proton shuttle are glycan strands substituted by cross-linked tetrapeptide-pentapeptide and tetrapeptide-tetrapeptide dimers and uncross-linked pentapeptide and tetrapeptide monomers. The acyl transferase of the PBP also catalyses aminolysis and hydrolysis of properly structured thiolesters, but it lacks activity on D-alanyl-D-alanine-terminated peptides. This substrate specificity suggests that carbonyl donor activity requires the attachment of the pentapeptides to the glycan chains made by the glycosyl transferase, and it implies that one and the same PBP molecule catalyses transglycosylation and peptide cross-linking in a sequential manner. Attempts to produce truncated forms of the PBP lead to the conclusion that the multimodular polypeptide chain behaves as an integrated folding entity during PBP1b biogenesis. [less ▲]

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See detailAntimicrobial Susceptibility of Streptococcus agalactiae isolated from patients in Belgium through 1989-1991 and 1996-1999
MELIN, Pierrette ULg; Rodriguez Cuns, Grisel; Vincento Fernandez, Walter et al

Poster (1999, October)

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See detailCrossover Iliofemoral Bypass Grafting for Treatment of Unilateral Iliac Atherosclerotic Disease
Defraigne, Jean-Olivier ULg; Vazquez, C.; Limet, Raymond ULg

in Journal of Vascular Surgery : Official Publication, the Society for Vascular Surgery and International Society For Cardiovascular Surgery, North American Chapter (1999), 30(4), 693-700

PURPOSE: In patients with unilateral iliac disease, a less invasive procedure than aortobifemoral bypass grafting may be desirable, especially in poor-risk patients or when sexual dysfunction is feared ... [more ▼]

PURPOSE: In patients with unilateral iliac disease, a less invasive procedure than aortobifemoral bypass grafting may be desirable, especially in poor-risk patients or when sexual dysfunction is feared. In these cases, femorofemoral (FF) bypass grafting is often proposed. Compared with FF bypass grafting, iliofemoral (IF) bypass grafting avoids bilateral exposure of the groins, which may reduce the risk of infection. When the primitive iliac artery is occluded from its origin or heavily calcified, one may use the contralateral artery as inflow, after a small retroperitoneal exposure, to perform a crossover iliofemoral (CIF) bypass grafting procedure, through the Retzius space. Our 10-year experience with CIF bypass grafting in a select group of patients was studied. METHODS: Between 1986 and 1996, 36 patients underwent CIF bypass grafting for symptomatic unilateral iliac occlusion or stenosis. All patients were examined by means of Doppler ultrasound scanning and underwent bilateral multiplane angiography. Patients were considered for this procedure when the ipsilateral common iliac artery was occluded from its origin or was diffusely and heavily calcified. The decision to perform a CIF bypass grafting procedure was made when no significant disease of the contralateral common iliac artery was seen, and patients who had features of contralateral iliac disease were excluded. The main outcomes were perioperative mortality and morbidity, long-term primary and secondary patency rates, and limb salvage rate. RESULTS: The study included 31 men and five women, with a mean age of 58.8 years. Indications for bypass grafting were disabling claudication (26 of 36 patients, 72%) and limb-threatening ischemia (10 of 26 patients, 28%). Twelve procedures were performed simultaneously: endarterectomy of the recipient common femoral artery (n = 3), femoropopliteal bypass grafting (n = 4, 11.1%), profundoplasty (n = 4, 11%), and right internal carotid endarterectomy (n = 1). New postoperative erectile dysfunction did not develop in any of the patients. The survival rate was 97.3% at 1 year and 68.5% at 5 years. The primary and secondary patency rates were 94% and 100%, respectively, at 1 year and 76.7% and 95%, respectively, at 5 years. The limb salvage rate was 100% at 1 year and 87% at 3 years. CONCLUSION: The operative mortality associated with CIF is low. The long-term primary and secondary patency rates are satisfactory, and they are lower than those reported for aortobifemoral bypass grafting. This procedure does not preclude a later performance of an aortobifemoral bypass grafting procedure. CIF bypass grafting is not only suitable for poor-risk patients with a limited life expectancy who have the appropriate arterial anatomy, but also may be warranted for young patients in whom erectile dysfunction is feared. [less ▲]

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See detailLack of Cell Wall Peptidoglycan Versus Penicillin Sensitivity: New Insights into the Chlamydial Anomaly
Ghuysen, Jean-Marie ULg; Goffin, Colette

in Antimicrobial Agents and Chemotherapy (1999), 43(10), 2339-2344

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See detailNew catalysis for fast bulk ring-opening polymerization of lactide monomers
Degée, Philippe; Dubois, Philippe ULg; Jérôme, Robert ULg et al

in Macromolecular Symposia (1999), 144

The ring-opening polymerization of lactides has been studied in bulk using either 2-ethylhexanoic acid tin(II) salt, Sn(Oct)2, or aluminum triisopropoxide, Al(OiPr)3, as the initiator over a wide range of ... [more ▼]

The ring-opening polymerization of lactides has been studied in bulk using either 2-ethylhexanoic acid tin(II) salt, Sn(Oct)2, or aluminum triisopropoxide, Al(OiPr)3, as the initiator over a wide range of temperature and monomer-to-initiator molar ratio, A high increase in the bulk polymerization rate has been observed when the initiator was added with an equimolar amount of a Lewis base, such as triphenylphosphine and 4-picoline (C6H7N) added to Sn(Oct)2 and Al(OiPr)3, respectively Melt stable polylactides of high molecular weight and reasonably narrow molecular weight distribution have been accordingly prepared. The use of the Sn(Oct)2. equimolar combination has allowed for reaching an acceptable balance between propagation and depolymerization rates, so that the polymerization is fast enough to be performed through a continuous single-stage process in a twin-screw extruder A global activation mechanism is proposed and discussed by comparison with both investigated initiation systems. [less ▲]

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See detailCulture of Gingival Fibroblasts on Bioabsorbable Regenerative Materials in Vitro
Simain-Sato, Franklin ULg; Lahmouzi, Jamila ULg; Kalykakis, G. K. et al

in Journal of Periodontology (1999), 70(10), 1234-9

BACKGROUND: The use of membranes in guided tissue regeneration (GTR) can limit the apical migration of gingival cells and favor the establishment of new attachment by periodontal ligament fibroblasts ... [more ▼]

BACKGROUND: The use of membranes in guided tissue regeneration (GTR) can limit the apical migration of gingival cells and favor the establishment of new attachment by periodontal ligament fibroblasts. However, gingival recession during healing following GTR has been described as a frequent complication. The purpose of this study was to determine if gingival fibroblasts are affected by the composition of the bioabsorbable membranes used in mucogingival surgery. METHODS: Two type of bioabsorbable regenerative materials were used as cell carriers. Wistar rat gingival fibroblasts (RGF) were obtained from attached gingiva, cut into small fragments, and placed in culture dishes. When confluent, cells were detached using trypsin and identified as "first transferred cells" (P1). At the third passage (P3), cell count, trypan blue exclusion test, acid phosphatase activity, DNA synthesis, phase contrast microscopy, and scanning electron microscopy were performed. The cells were then placed in wells containing the membranes and incubated for 72 hours. RESULTS: When examined under microscopy, the control wells (without membranes) showed one cell type with the elongated appearance characteristic of fibroblasts. The wells with membranes showed an altered cell morphology with a high proportion of cell fragments regardless of the type of membrane used. CONCLUSIONS: These results suggest that cell carrier membranes could affect RGF morphology and thus alter gingival tissue healing following GTR. [less ▲]

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