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See detailShemin Pathway and Peroxidase Deficiency in a Fully Habituated and Fully Heterotrophic Non-Organogenic Sugarbeet Callus: An Adaptative Strategy or the Consequence of Modified Hormonal Balances and Sensitivities in These Cancerous Cells? A Review an
Gaspar, Thomas ULg; Kevers, Claire ULg; Bisbis, Badia et al

in Cell Proliferation (1999), 32(5), 249-70

There are many arguments for considering a specific fully habituated (auxin and cytokinin-independent) and fully heterotrophic non-organogenic (HNO) sugarbeet callus cell line as terminating a neoplastic ... [more ▼]

There are many arguments for considering a specific fully habituated (auxin and cytokinin-independent) and fully heterotrophic non-organogenic (HNO) sugarbeet callus cell line as terminating a neoplastic progression, and thus to be made of cancerous cells. The similarities with animal tumour and cancer cells are recalled. All types of habituated tissues examined in the literature share at least three common biochemical characteristics: low apparent peroxidase activity, high content of polyamines (PAs) and low production of ethylene. However, results concerning their auxin and cytokinin levels are not consistent. Peroxidase synthesis in the achlorophyllous HNO callus appears to arise from aminolevulinic acid (ALA) synthesis through the Shemin pathway, commonly used by animals and fungi. This pathway is limited by disturbed nitrogen metabolism that diverts glutamate (directly used for ALA synthesis in green higher plants) from the Kreb's cycle into PA synthesis. There is no argument to suggest that the low ethylene production is caused by a competition with PAs for their common precursor, S-adenosylmethionine. The results we report here indicate modified anabolic and catabolic pathways of auxins and cytokinins but also the possibilities of unusual compounds playing similar roles (dehydrodiconiferyl alcohol glucosides, for instance). A higher turnover of PAs is shown in the HNO callus, which could suggest a role for H2O2 and gamma-aminobutyric acid, products or intermediates in the PA catabolic pathway, as secondary messengers. The habituated cells retain some sensitivity towards exogenous auxins and cytokinins. Their increased sensitivity to PAs and ethylene suggests modified hormonal balances for the control of these actively dividing cells. [less ▲]

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See detailFire Models for Safety Concept of Steel Structures - I modelli di incendio per la valutazione della sicurezza di strutture in acciaio
Pustorino, Sandro; Schleich, Jean-Baptiste; Cadorin, Jean-François et al

in Proc. XVII Congresso C.T.A., Costruire in acciaio: Strutture e architettura (1999, October)

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See detailAid to Cocneption of the Building Envelope, Before, During the Sketch Design
Hauglustaine, Jean-Marie ULg

Report (1999)

In the conception of the envelope of a building, the sketch design is a crucial moment of the design. The first drawing gives a concrete expression to the first choices of the project author, in respect ... [more ▼]

In the conception of the envelope of a building, the sketch design is a crucial moment of the design. The first drawing gives a concrete expression to the first choices of the project author, in respect of a set of requirements and of general preferences, expressed by the multiple stakeholders of the project, namely: the building owner, the users, the adminstrative authorities and the design team surrounding the architect. In order to help the stakeholders in improving this stage of the sketch design, the present study explores a multicriteria decision aiding procedure. This MultiCriteria Decision Aid (MCDA) methodology should be close to the usual design process. This paper presents the design and the decision aid procedures, in parallel. At this time of the study, the decision aid process is a first attempt to cope with this architectural design challenge. The floor is expected to react to the suggested presentation of this MCDA open problem. [less ▲]

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See detailRole of Nuclear Factor-Kappa B in Colon Cancer Cell Apoptosis Mediated by Aminopyropheophorbide Photosensitization
Matroule, J. Y.; Hellin, A. C.; Morliere, P. et al

in Photochemistry & Photobiology (1999), 70(4), 540-8

Aminopyropheophorbide (APP) is a second generation of photosensitizer for photodynamic therapy (PDT). We demonstrated that APP strongly absorbed red light and, after being taken up by colon cancer cells ... [more ▼]

Aminopyropheophorbide (APP) is a second generation of photosensitizer for photodynamic therapy (PDT). We demonstrated that APP strongly absorbed red light and, after being taken up by colon cancer cells (HCT-116 cells), was localized in cytoplasmic and internal membranes but not in mitochondria. The APP-mediated photosensitization was cytotoxic for HCT-116 cells through an induction of apoptosis. Indeed, DNA fragmentation (DNA laddering and terminal deoxyuridine nick-end labeling) and chromatin condensation (4',6-diamidine-2'-phenylindole staining) could be visualized soon after photosensitization. Because nuclear factor (NF)-kappa B is involved in the response to many photosensitizers, we also demonstrated its nuclear translocation in two waves: a rapid and transient one, followed by a slow and sustained phase. The NF-kappa B turned out to be involved in an antiapoptotic response to APP-mediated photosensitization because the HCT-116 cell line expressing the dominant negative mutant of inhibitor-kappa B alpha was more sensitive to apoptosis as measured by DNA fragmentation and caspase activation. These data unambiguously show that a membrane-located photosensitizer can lead to effective apoptosis, reinforcing the idea that PDT can be an effective means to eradicate colon cancer cells. [less ▲]

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See detailMulti-aspects architectural design: the conception of new building envelopes
Dupagne, Albert ULg; Hauglustaine, Jean-Marie ULg

Conference (1999, October)

The building is not a unique object any more, but results from the assembly of components, among which the envelope is one of the objects assembled. The components are more and more specialised and ... [more ▼]

The building is not a unique object any more, but results from the assembly of components, among which the envelope is one of the objects assembled. The components are more and more specialised and acquire an actual independence. On the other hand, the components of the building and of the envelope have a large diversity of life cycles; moreover the life duration of the components shortens, because they rapidly become obsolescent from many points of view: technology, technique, performance, functionality, etc., so that their easy transformability, adaptability (and/or removability) becomes an important quality required to them. The conception of new building envelopes must take these aspects into account, in order to obtain a best practice design. [less ▲]

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See detailMarqueurs cardiaques : CK-MB ou troponines?
Chapelle, Jean-Paul ULg; Legrand, Victor ULg

Conference (1999, October)

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See detailApplication of nuclear scintigraphy to evaluation of pulmonary function
Votion, Dominique ULg

in In Proceedings: 17th Comparative Respiratory Society Meeting (1999, October)

Nuclear imaging techniques have a long history in pulmonary medicine and the clinical and experimental uses of lung scintigraphy have largely expanded these last years. Currently, the pulmonary ... [more ▼]

Nuclear imaging techniques have a long history in pulmonary medicine and the clinical and experimental uses of lung scintigraphy have largely expanded these last years. Currently, the pulmonary applications of nuclear scintigraphy are essentially: (I), the study of regional lung function; (II), the imaging of pulmonary infection and/or inflammation; (III), the determination of inflammatory cells involvement in lung diseases; (IV), the assessment of the alveolar-capillary barrier integrity; (V), the imaging of lung cancers and (VI), the study of aerosol deposition within the lung. Many faculty of veterinary medicine have acquired nuclear imaging facilities. The primary application of scintigraphy is in the investigation of equine orthopaedic conditions and, with the exception of rodents, only a few publications report the use of lung scintigraphy in any animal species. Nevertheless, lung scintigraphy using animals would be of great interest to better understand the lung physiology in general as well as animals’ peculiarities in particular. Following a brief introduction to the technique, this paper will review the main applications of pulmonary scintigraphy and will survey some new nuclear imaging techniques that should be available in the next future. [less ▲]

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See detailPotential effects of NSAID on myocellular enzyme leakage and delayed onset muscle soreness induced by isokinetic eccentric exercise
Croisier, Jean-Louis ULg; Camus, Gérard; Crielaard, Jean-Michel ULg

in Actes du XIXe Congrès National de la Société Française de Médecine du Sport (1999, October)

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See detailUne analyse de discours spécifique : le média de masse
Servais, Christine ULg

Scientific conference (1999, October)

Detailed reference viewed: 41 (16 ULg)
See detailBrève sociologie de la littérature belge
Servais, Christine ULg

Scientific conference (1999, October)

Detailed reference viewed: 10 (1 ULg)
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See detailReflux gastro-oesophagien et asthme
Lamproye, Anne ULg; Louis, Edouard ULg; Louis, Renaud ULg et al

in Revue Médicale de Liège (1999), 54(10), 805-8

Gastro-oesophageal reflux (GER) is more frequent in asthmatic patients than in the community at large. A causative association between the two diseases is suspected. Twenty-four hour ambulatory ... [more ▼]

Gastro-oesophageal reflux (GER) is more frequent in asthmatic patients than in the community at large. A causative association between the two diseases is suspected. Twenty-four hour ambulatory intraoesophageal pH monitoring represents the golden standard for the diagnosis of GER. The medical and/or surgical treatment of reflux in asthmatic patients with GER can improve pulmonary symptoms and to a lesser extent pulmonary function. The selection of the patients who will benefit from a GER treatment is difficult. Some symptoms like intrinsic asthma, nocturnal crises, could predict a good response to GER treatment. [less ▲]

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See detailPharma clinics. Le médicament du mois. La lercanidipine (Zanidip)
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1999), 54(10), 832-834

Lercanidipine (Zanidip) is a new calcium antagonist belonging to the dihydropyridine family suitable for the first-line treatment of hypertension. This molecule displays a high specificity and selectivity ... [more ▼]

Lercanidipine (Zanidip) is a new calcium antagonist belonging to the dihydropyridine family suitable for the first-line treatment of hypertension. This molecule displays a high specificity and selectivity for vascular smooth muscle cells and has, in spite of a short plasma half-life, a long duration of action due to its liposolubility. The usual and once a day dose to treat high blood pressure of any grade is 10 mg, which if needed could be increased to 20 mg once a day. It has a gradual onset of effect on blood pressure, thus leading to a good tolerability and hopefully a better compliance in the treatment of hypertension. No adaptation of the dose is needed in older patients or in patients with moderate renal or liver impairment. [less ▲]

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See detailA general framework for power system transient stability control
Pavella, Mania ULg; Ernst, Damien ULg; Ruiz-Vega, Daniel

in IEEE Power Engineering Society Letters (1999), 19(10), 45-46

Detailed reference viewed: 51 (6 ULg)
See detailSymposium Acromegaly : Current treatment modalities and pre-surgical approaches of acromegaly
Beckers, Albert ULg

Scientific conference (1999, October)

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See detailKinetics modelling of convective heat drying of wastewater treatment sludge
Léonard, Angélique ULg; Salmon, Thierry ULg; Janssens et al

in Flamand, G. (Ed.) Récents progrés en génie des procédés vol.13 n.68 : separations. ECCE 2 conference Montpellier 5/7.10.99 (1999, October)

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See detailCharacterization of nonlinear aeroservoelastic behaviour
Dimitriadis, Grigorios ULg; Cooper, Jonathan Edware

in RTO-MP-036 Structural Aspects of Flexible Aircraft Control (1999, October)

The characterisation of the behaviour of nonlinear aeroelastic systems has become a very important re- search topic. Nevertheless, most of the work carried out to date concerns the development of unsteady ... [more ▼]

The characterisation of the behaviour of nonlinear aeroelastic systems has become a very important re- search topic. Nevertheless, most of the work carried out to date concerns the development of unsteady CFD solutions in the transonic region. Important though this work is, there is also a need for research which aims at understanding the behaviour of non- linear systems, particularly the occurance of Limit Cycle Oscillations (LCOs). The purpose of this pa- per is to study the stability of a simple aeroservoelas- tic system with nonlinearities in the control system. The work considers both structural and control law nonlinearities and assesses the stability of the system response by use of bifurcation diagrams. It is shown that simple feedback systems designed to increase the stability of the linearised system also stabilise the nonlinear system, although their effects can be less pronounced. Additionally, a nonlinear control law designed to limit the control surface pitch response was found to increase the flutter speed considerably by forcing the system to undergo limit cycle oscilla- tions instead of fluttering. Finally, friction was found to affect the damping of the system but not its sta- bility, as long as the amplitude of the frictional force is low enough not to cause stoppages in the motion. [less ▲]

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