Fire Models for Safety Concept of Steel Structures - I modelli di incendio per la valutazione della sicurezza di strutture in acciaio

in Proc. XVII Congresso C.T.A., Costruire in acciaio: Strutture e architettura (1999, October)

Role of Nuclear Factor-Kappa B in Colon Cancer Cell Apoptosis Mediated by Aminopyropheophorbide Photosensitization

in Photochemistry & Photobiology (1999), 70(4), 540-8

Aminopyropheophorbide (APP) is a second generation of photosensitizer for photodynamic therapy (PDT). We demonstrated that APP strongly absorbed red light and, after being taken up by colon cancer cells ... [more ▼]

Aminopyropheophorbide (APP) is a second generation of photosensitizer for photodynamic therapy (PDT). We demonstrated that APP strongly absorbed red light and, after being taken up by colon cancer cells (HCT-116 cells), was localized in cytoplasmic and internal membranes but not in mitochondria. The APP-mediated photosensitization was cytotoxic for HCT-116 cells through an induction of apoptosis. Indeed, DNA fragmentation (DNA laddering and terminal deoxyuridine nick-end labeling) and chromatin condensation (4',6-diamidine-2'-phenylindole staining) could be visualized soon after photosensitization. Because nuclear factor (NF)-kappa B is involved in the response to many photosensitizers, we also demonstrated its nuclear translocation in two waves: a rapid and transient one, followed by a slow and sustained phase. The NF-kappa B turned out to be involved in an antiapoptotic response to APP-mediated photosensitization because the HCT-116 cell line expressing the dominant negative mutant of inhibitor-kappa B alpha was more sensitive to apoptosis as measured by DNA fragmentation and caspase activation. These data unambiguously show that a membrane-located photosensitizer can lead to effective apoptosis, reinforcing the idea that PDT can be an effective means to eradicate colon cancer cells. [less ▲]

Dosage de la troponine I cardiaque sur l'analyseur stratus cs: expérience en laboratoire hospitalier

Conference (1999, October)

Application of nuclear scintigraphy to evaluation of pulmonary function

in In Proceedings: 17th Comparative Respiratory Society Meeting (1999, October)

Nuclear imaging techniques have a long history in pulmonary medicine and the clinical and experimental uses of lung scintigraphy have largely expanded these last years. Currently, the pulmonary ... [more ▼]

Nuclear imaging techniques have a long history in pulmonary medicine and the clinical and experimental uses of lung scintigraphy have largely expanded these last years. Currently, the pulmonary applications of nuclear scintigraphy are essentially: (I), the study of regional lung function; (II), the imaging of pulmonary infection and/or inflammation; (III), the determination of inflammatory cells involvement in lung diseases; (IV), the assessment of the alveolar-capillary barrier integrity; (V), the imaging of lung cancers and (VI), the study of aerosol deposition within the lung. Many faculty of veterinary medicine have acquired nuclear imaging facilities. The primary application of scintigraphy is in the investigation of equine orthopaedic conditions and, with the exception of rodents, only a few publications report the use of lung scintigraphy in any animal species. Nevertheless, lung scintigraphy using animals would be of great interest to better understand the lung physiology in general as well as animals’ peculiarities in particular. Following a brief introduction to the technique, this paper will review the main applications of pulmonary scintigraphy and will survey some new nuclear imaging techniques that should be available in the next future. [less ▲]

Une analyse de discours spécifique : le média de masse

Scientific conference (1999, October)

Reflux gastro-oesophagien et asthme

in Revue Médicale de Liège (1999), 54(10), 805-8

Gastro-oesophageal reflux (GER) is more frequent in asthmatic patients than in the community at large. A causative association between the two diseases is suspected. Twenty-four hour ambulatory ... [more ▼]

Gastro-oesophageal reflux (GER) is more frequent in asthmatic patients than in the community at large. A causative association between the two diseases is suspected. Twenty-four hour ambulatory intraoesophageal pH monitoring represents the golden standard for the diagnosis of GER. The medical and/or surgical treatment of reflux in asthmatic patients with GER can improve pulmonary symptoms and to a lesser extent pulmonary function. The selection of the patients who will benefit from a GER treatment is difficult. Some symptoms like intrinsic asthma, nocturnal crises, could predict a good response to GER treatment. [less ▲]

A general framework for power system transient stability control

in IEEE Power Engineering Society Letters (1999), 19(10), 45-46

Symposium Acromegaly : Current treatment modalities and pre-surgical approaches of acromegaly

Scientific conference (1999, October)

Characterization of nonlinear aeroservoelastic behaviour

in RTO-MP-036 Structural Aspects of Flexible Aircraft Control (1999, October)

The characterisation of the behaviour of nonlinear aeroelastic systems has become a very important re- search topic. Nevertheless, most of the work carried out to date concerns the development of unsteady ... [more ▼]

The characterisation of the behaviour of nonlinear aeroelastic systems has become a very important re- search topic. Nevertheless, most of the work carried out to date concerns the development of unsteady CFD solutions in the transonic region. Important though this work is, there is also a need for research which aims at understanding the behaviour of non- linear systems, particularly the occurance of Limit Cycle Oscillations (LCOs). The purpose of this pa- per is to study the stability of a simple aeroservoelas- tic system with nonlinearities in the control system. The work considers both structural and control law nonlinearities and assesses the stability of the system response by use of bifurcation diagrams. It is shown that simple feedback systems designed to increase the stability of the linearised system also stabilise the nonlinear system, although their effects can be less pronounced. Additionally, a nonlinear control law designed to limit the control surface pitch response was found to increase the flutter speed considerably by forcing the system to undergo limit cycle oscilla- tions instead of fluttering. Finally, friction was found to affect the damping of the system but not its sta- bility, as long as the amplitude of the frictional force is low enough not to cause stoppages in the motion. [less ▲]

Etude des causes de la ruine du Bateau Ave Maria,

Report (1999)