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See detailAcceptance tests of the INTEGRAL Optical Monitoring Camera subsystems
Mazy, Emmanuel ULg; Plesseria, Jean-Yves ULg; Renotte, Etienne ULg et al

in Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series (1999, October 01)

The Optical Monitoring Camera (OMC) is a part of the scientific payload being developed for the ESA INTEGRAL mission, scheduled to be launched in 2001. The OMC is a imager that will monitor star ... [more ▼]

The Optical Monitoring Camera (OMC) is a part of the scientific payload being developed for the ESA INTEGRAL mission, scheduled to be launched in 2001. The OMC is a imager that will monitor star variations in the V-band in a 5 X 5 degree(s) field of view. This paper describes the acceptance tests for 3 sub-systems of OMC: the optical system, the baffle and the cover system. [less ▲]

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See detailOptical calibration of the FUV spectrographic imager for the IMAGE mission
Habraken, Serge ULg; Houbrechts, Yvette ULg; Renotte, Etienne ULg et al

in Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series (1999, October 01)

The FUV Spectrographic Imager for IMAGE is simultaneously imaging auroras at 1218 and 1358 angstrom. It is designed to efficiently reject the Lyman-(alpha) emission line at 1215.7 angstrom. This paper ... [more ▼]

The FUV Spectrographic Imager for IMAGE is simultaneously imaging auroras at 1218 and 1358 angstrom. It is designed to efficiently reject the Lyman-(alpha) emission line at 1215.7 angstrom. This paper describes the optical calibration. The content is: 1) field of view calibration: detector pixels location with respect to the reference optical cube; distortion matrix used to computer the TDI. b) Radiometric calibration: detector response and linearity; instrument throughput according to its clear aperture and mirror reflection lost; response vs. wavelength and band-rejection certification. [less ▲]

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See detailPSF modeling of the XMM flight mirror modules
Stockman, Yvan ULg; Houbrechts, Yvette ULg; Nazé, Yaël ULg et al

in Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series (1999, October 01)

In the frame of XMM testing, all the mirror modules have been illuminated by a vertical EUV collimated beam a the Centre Spatial de Liege. A mirror module consists in 58 co- focal and co-axial Wolter I ... [more ▼]

In the frame of XMM testing, all the mirror modules have been illuminated by a vertical EUV collimated beam a the Centre Spatial de Liege. A mirror module consists in 58 co- focal and co-axial Wolter I mirrors. Up to now the images obtained at CSL have been used to assess the Mirror Module optical performances in a flight representative configuration, and also to verify the impact of the thermal environmental and vibration test on the optical performance. Due to the highly complex design of the Mirror Modules, simulating XMM images in details is very difficult. The Point Spread Function of some of the mirror modules presents slight asymmetry. In the facility design study, it has been demonstrated that the diffraction impact at 58.4 nm is negligible with respect to the half energy width mirror module specification. Presently all the mirror modules are better than 165 arcsec. This paper presents first the diffraction contribution on the image. In a second step a point spread function is built by using the metrological mirror shell data. EUV images are then analyzed to evaluate the impact of the mirror interface structure integration process on the PSF. An analytical model of the measured EUV pSF is developed. The modelization technique is applied to simulate in-orbit image. Finally the different modelizations are evaluated and compared. [less ▲]

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See detailGravitational lensing studies with the 4-m International Liquid Mirror Telescope (ILMT)
Jean, C.; Claeskens, J *-F; Surdej, Jean ULg

Poster (1999, October 01)

A 4-m International Liquid Mirror Telescope (ILMT) is being built in the north of Chile by an international consortium and will become operational in two years from now. We present here a short ... [more ▼]

A 4-m International Liquid Mirror Telescope (ILMT) is being built in the north of Chile by an international consortium and will become operational in two years from now. We present here a short description of the telescope as well as estimates of the microlensing, macrolensing and weak lensing effects expected from a deep, multicolor imaging survey made with such a telescope. [less ▲]

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See detailIntérêt d'une procédure de rappel indicé à 48 items dans le diagnostic précoce de la maladie d'Alzheimer
Ivanoiu, Adrian; Adam, Stéphane ULg; Bechet, Sophie et al

in Revue Neurologique (1999, October 01), 155(Supplément 3), 63-64

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See detailEffets antitumoraux des agonistes dopaminergiques et des analogues de la somatostatine
Beckers, Albert ULg; Valdes Socin, Hernan Gonzalo ULg; Stevenaert, Achille ULg

in Médecine Thérapeutique Endocrinologie (1999), 1(2), 183-191

Le traitement médicamenteux des adénomes hypophysaires commence son histoire au début des années 70. La bromocriptine qui vient d’être découverte s’avère efficace pour traiter l’hyperprolactinémie et ... [more ▼]

Le traitement médicamenteux des adénomes hypophysaires commence son histoire au début des années 70. La bromocriptine qui vient d’être découverte s’avère efficace pour traiter l’hyperprolactinémie et restaurer la fertilité chez les femmes hyperprolactinémiques. Son effet antitumoral est découvert un peu plus tard lorsque des scanners performants permettent d’observer une diminution de volume de l’adénome. Au cours des vingt dernières années, des progrès substantiels ont été accomplis dans le traitement médical des adénomes hypophysaires et dans les techniques qui permettent leur observation et leur suivi. Des molécules plus puissantes que la bromocriptine sont maintenant disponibles pour le traitement des adénomes à prolactine (PRL). Les plus utilisées et les plus connues sont le quinagolide et la cabergoline. En outre, de nouveaux traitements médicamenteux, s’adressant cette fois à l’adénome somatotrope, ont vu le jour. La somatostatine a été découverte en 1973. Sa demi-vie très courte et les effets rebond observés après son injection ne permettaient toutefois pas de l’utiliser pour soigner l’acromégalie. Il a fallu attendre le milieu des années 80 pour disposer du premier analogue efficace dans cette indication : l’octréotide. Depuis, les préparations à effet retard ont vu le jour (Sandostatine® LAR, Somatuline® LP). Elles permettent une normalisation de la sécrétion de l’hormone de croissance (growth hormone, GH) dans l’acromégalie dans plus de la moitié des cas. Il est rapidement devenu évident que ces médicaments étaient aussi capables d’entraîner une réduction du volume des adénomes dans un pourcentage significatif de cas. Parallèlement, les progrès techniques ont permis la mise au point de scanners hyperperformants et, surtout, d’examens par résonance magnétique nucléaire (IRM). Actuellement, ce type d’examens a remplacé le scanner dans l’évaluation des adénomes hypophysaires. Il permet, en effet, de repérer des lésions de plus petite taille qu’avant, de mieux définir les limites entre la tumeur, l’hypophyse normale et les structures avoisinantes, notamment dans les macro-adénomes, et, en outre, de mieux caractériser les phénomènes intratumoraux tels que la nécrose ou l’hémorragie. Dans cet article nous revoyons les effets antitumoraux des analogues de la somatostatine et des agonistes dopaminergiques dans l’acromégalie et chez les patients porteurs d’adénome à prolactine. Les divers types de réponses, aussi bien dans les micro-adénomes que dans les macro-adénomes, seront envisagés à l’occasion de la description de cas cliniques illustratifs, puis une synthèse générale sera présentée. [less ▲]

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See detailEndurance training versus combined strength and endurance training in leisure-time cyclists
Weiler, B.; Urhausen, A.; Dahm, C. et al

in International Journal of Sports Medicine (1999, October), 20

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See detailAlphacalcidol in Prevention of Glucocorticoid-Induced Osteoporosis
Reginster, Jean-Yves ULg; de Froidmont, C.; Lecart, M. P. et al

in Calcified Tissue International (1999), 65(4), 328-31

One of the major drawbacks of glucocorticoids long-term therapy is the occurrence of a severe osteoporosis characterized by fractures occurring at different sites, mainly at the level of trabecular bone ... [more ▼]

One of the major drawbacks of glucocorticoids long-term therapy is the occurrence of a severe osteoporosis characterized by fractures occurring at different sites, mainly at the level of trabecular bone. One of the major determinants of glucocorticoid-induced osteoporosis is a decrease in the intestinal absorption of calcium (Ca) leading to a secondary hyperparathyroidism. D-hormones have been shown to significantly improve Ca absorption in the gut and subsequently to decrease parathyroid hormone circulating levels, hence normalizing bone turnover. In a recent study evaluating 145 patients suffering from diseases requiring long-term treatment with high doses of corticosteroids, we have demonstrated a significant benefit of alphacalcidol (1 microg/day) over placebo in terms of changes in bone mineral density of the lumbar spine. These results are in accordance with studies showing better prevention of bone loss and vertebral fractures in cardiac transplant patients treated with alphacalcidol than those treated with etidronate. There is now a convergent body of evidence to suggest that alphacalcidol is a reasonable, safe, and effective option for the prevention of glucocorticoid-induced osteoporosis, provided that serum Ca is monitored on a regular basis. [less ▲]

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See detailShemin Pathway and Peroxidase Deficiency in a Fully Habituated and Fully Heterotrophic Non-Organogenic Sugarbeet Callus: An Adaptative Strategy or the Consequence of Modified Hormonal Balances and Sensitivities in These Cancerous Cells? A Review an
Gaspar, Thomas ULg; Kevers, Claire ULg; Bisbis, Badia et al

in Cell Proliferation (1999), 32(5), 249-70

There are many arguments for considering a specific fully habituated (auxin and cytokinin-independent) and fully heterotrophic non-organogenic (HNO) sugarbeet callus cell line as terminating a neoplastic ... [more ▼]

There are many arguments for considering a specific fully habituated (auxin and cytokinin-independent) and fully heterotrophic non-organogenic (HNO) sugarbeet callus cell line as terminating a neoplastic progression, and thus to be made of cancerous cells. The similarities with animal tumour and cancer cells are recalled. All types of habituated tissues examined in the literature share at least three common biochemical characteristics: low apparent peroxidase activity, high content of polyamines (PAs) and low production of ethylene. However, results concerning their auxin and cytokinin levels are not consistent. Peroxidase synthesis in the achlorophyllous HNO callus appears to arise from aminolevulinic acid (ALA) synthesis through the Shemin pathway, commonly used by animals and fungi. This pathway is limited by disturbed nitrogen metabolism that diverts glutamate (directly used for ALA synthesis in green higher plants) from the Kreb's cycle into PA synthesis. There is no argument to suggest that the low ethylene production is caused by a competition with PAs for their common precursor, S-adenosylmethionine. The results we report here indicate modified anabolic and catabolic pathways of auxins and cytokinins but also the possibilities of unusual compounds playing similar roles (dehydrodiconiferyl alcohol glucosides, for instance). A higher turnover of PAs is shown in the HNO callus, which could suggest a role for H2O2 and gamma-aminobutyric acid, products or intermediates in the PA catabolic pathway, as secondary messengers. The habituated cells retain some sensitivity towards exogenous auxins and cytokinins. Their increased sensitivity to PAs and ethylene suggests modified hormonal balances for the control of these actively dividing cells. [less ▲]

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See detailFire Models for Safety Concept of Steel Structures - I modelli di incendio per la valutazione della sicurezza di strutture in acciaio
Pustorino, Sandro; Schleich, Jean-Baptiste; Cadorin, Jean-François et al

in Proc. XVII Congresso C.T.A., Costruire in acciaio: Strutture e architettura (1999, October)

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See detailAid to Cocneption of the Building Envelope, Before, During the Sketch Design
Hauglustaine, Jean-Marie ULg

Report (1999)

In the conception of the envelope of a building, the sketch design is a crucial moment of the design. The first drawing gives a concrete expression to the first choices of the project author, in respect ... [more ▼]

In the conception of the envelope of a building, the sketch design is a crucial moment of the design. The first drawing gives a concrete expression to the first choices of the project author, in respect of a set of requirements and of general preferences, expressed by the multiple stakeholders of the project, namely: the building owner, the users, the adminstrative authorities and the design team surrounding the architect. In order to help the stakeholders in improving this stage of the sketch design, the present study explores a multicriteria decision aiding procedure. This MultiCriteria Decision Aid (MCDA) methodology should be close to the usual design process. This paper presents the design and the decision aid procedures, in parallel. At this time of the study, the decision aid process is a first attempt to cope with this architectural design challenge. The floor is expected to react to the suggested presentation of this MCDA open problem. [less ▲]

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See detailRole of Nuclear Factor-Kappa B in Colon Cancer Cell Apoptosis Mediated by Aminopyropheophorbide Photosensitization
Matroule, J. Y.; Hellin, A. C.; Morliere, P. et al

in Photochemistry & Photobiology (1999), 70(4), 540-8

Aminopyropheophorbide (APP) is a second generation of photosensitizer for photodynamic therapy (PDT). We demonstrated that APP strongly absorbed red light and, after being taken up by colon cancer cells ... [more ▼]

Aminopyropheophorbide (APP) is a second generation of photosensitizer for photodynamic therapy (PDT). We demonstrated that APP strongly absorbed red light and, after being taken up by colon cancer cells (HCT-116 cells), was localized in cytoplasmic and internal membranes but not in mitochondria. The APP-mediated photosensitization was cytotoxic for HCT-116 cells through an induction of apoptosis. Indeed, DNA fragmentation (DNA laddering and terminal deoxyuridine nick-end labeling) and chromatin condensation (4',6-diamidine-2'-phenylindole staining) could be visualized soon after photosensitization. Because nuclear factor (NF)-kappa B is involved in the response to many photosensitizers, we also demonstrated its nuclear translocation in two waves: a rapid and transient one, followed by a slow and sustained phase. The NF-kappa B turned out to be involved in an antiapoptotic response to APP-mediated photosensitization because the HCT-116 cell line expressing the dominant negative mutant of inhibitor-kappa B alpha was more sensitive to apoptosis as measured by DNA fragmentation and caspase activation. These data unambiguously show that a membrane-located photosensitizer can lead to effective apoptosis, reinforcing the idea that PDT can be an effective means to eradicate colon cancer cells. [less ▲]

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See detailMulti-aspects architectural design: the conception of new building envelopes
Dupagne, Albert ULg; Hauglustaine, Jean-Marie ULg

Conference (1999, October)

The building is not a unique object any more, but results from the assembly of components, among which the envelope is one of the objects assembled. The components are more and more specialised and ... [more ▼]

The building is not a unique object any more, but results from the assembly of components, among which the envelope is one of the objects assembled. The components are more and more specialised and acquire an actual independence. On the other hand, the components of the building and of the envelope have a large diversity of life cycles; moreover the life duration of the components shortens, because they rapidly become obsolescent from many points of view: technology, technique, performance, functionality, etc., so that their easy transformability, adaptability (and/or removability) becomes an important quality required to them. The conception of new building envelopes must take these aspects into account, in order to obtain a best practice design. [less ▲]

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See detailMarqueurs cardiaques : CK-MB ou troponines?
Chapelle, Jean-Paul ULg; Legrand, Victor ULg

Conference (1999, October)

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See detailApplication of nuclear scintigraphy to evaluation of pulmonary function
Votion, Dominique ULg

in In Proceedings: 17th Comparative Respiratory Society Meeting (1999, October)

Nuclear imaging techniques have a long history in pulmonary medicine and the clinical and experimental uses of lung scintigraphy have largely expanded these last years. Currently, the pulmonary ... [more ▼]

Nuclear imaging techniques have a long history in pulmonary medicine and the clinical and experimental uses of lung scintigraphy have largely expanded these last years. Currently, the pulmonary applications of nuclear scintigraphy are essentially: (I), the study of regional lung function; (II), the imaging of pulmonary infection and/or inflammation; (III), the determination of inflammatory cells involvement in lung diseases; (IV), the assessment of the alveolar-capillary barrier integrity; (V), the imaging of lung cancers and (VI), the study of aerosol deposition within the lung. Many faculty of veterinary medicine have acquired nuclear imaging facilities. The primary application of scintigraphy is in the investigation of equine orthopaedic conditions and, with the exception of rodents, only a few publications report the use of lung scintigraphy in any animal species. Nevertheless, lung scintigraphy using animals would be of great interest to better understand the lung physiology in general as well as animals’ peculiarities in particular. Following a brief introduction to the technique, this paper will review the main applications of pulmonary scintigraphy and will survey some new nuclear imaging techniques that should be available in the next future. [less ▲]

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See detailPotential effects of NSAID on myocellular enzyme leakage and delayed onset muscle soreness induced by isokinetic eccentric exercise
Croisier, Jean-Louis ULg; Camus, Gérard; Crielaard, Jean-Michel ULg

in Actes du XIXe Congrès National de la Société Française de Médecine du Sport (1999, October)

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See detailUne analyse de discours spécifique : le média de masse
Servais, Christine ULg

Scientific conference (1999, October)

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