References of "1999"
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See detailLa transformation semi-industrielle des produits fermentés à base de mil au Sénégal : procédés qualité et contraintes au développement industriel.
Leite, N.; Totte, A.; Diop, M. et al

in Actes de l'Atelier International : "Les petites industries agro-alimentaire pour une nutrition saine en afrique de l'Ouest". (1999, November)

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See detailAntiplatelet Activity of Clopidogrel in Coronary Artery Bypass Graft Surgery Patients
David, Jean-Louis ULg; Limet, Raymond ULg

in Thrombosis and Haemostasis (1999), 82(5), 1417-21

Clopidogrel is a recently introduced platelet ADP receptor antagonist, belonging to the thienopyridine derivatives, like its analogue ticlopidine. Its potential advantage is to be safer than ticlopidine ... [more ▼]

Clopidogrel is a recently introduced platelet ADP receptor antagonist, belonging to the thienopyridine derivatives, like its analogue ticlopidine. Its potential advantage is to be safer than ticlopidine. At 75 mg/od clopidogrel significantly inhibits platelet aggregation in ambulatory patients with symptomatic atherosclerotic disease and it prevents the recurrence of ischemic events more efficiently than aspirin. Its adequate dose in more acute situations remained to be determined. Therefore, sixty two patients with coronary artery disease were randomly assigned in four groups treated, within 24 h after coronary artery bypass graft, by clopidogrel 50 mg/od, 75 mg/od or 100 mg/od or by ticlopidine 250 mg/bid which was considered as the reference. The tolerance of clopidogrel was fairly good during the whole period of the study. Bleeding time and ex-vivo platelet aggregation induced by ADP 2 microM and 5 microM were performed at day -1, +9 and +28 after surgery. Like ticlopidine, the three dose levels of clopidogrel significantly inhibited ex-vivo platelet activity and prolonged the bleeding time at day 28. However, unlike ticlopidine, the inhibitory effects of clopidogrel were not significant at day 9, especially with 75 mg/od, a dose which was found to significantly protect patients in a chronic situation. Hence, although the clinical outcome for patients included in this limited study was the same in the four groups, these results suggest that the dose regime of clopidogrel should be more extensively investigated during the early period following coronary artery bypass graft, facing an overproduction of young and hyperreactive platelets. By analogy, the dose regime should be also investigated in other situations with an acute risk of arterial thrombotic occlusion. [less ▲]

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See detailEvaluation of frequency and type of errors detected by a computerized record and verify system during radiation treatment
Barthelemy, Nicole ULg; Sabatier, Jacques; Dewé, Walthère ULg et al

in Radiotherapy & Oncology (1999), 53(2), 149-54

Background: Computerized record and verify systems (RVS) have been introduced to improve the precision of radiation treatment delivery. These systems prevent the delivery of ionizing radiations when the ... [more ▼]

Background: Computerized record and verify systems (RVS) have been introduced to improve the precision of radiation treatment delivery. These systems prevent the delivery of ionizing radiations when the settings of the treatment machine do not match the intended parameters within some maximal authorized deviation. Purpose: To assess the potential alteration of the frequency of errors associated with the use of RVS during radiation treatment delivery. Materials and methods: The software of the RVS was altered in order to record the settings actually used for radiation treatment delivery whereas the verification function was suppressed. At the end of the study period, the settings used during daily administration of radiation treatment were compared to the parameters recorded in the RVS using the computer. They were also compared with the planned ones written in the patient treatment chart. Results: Out of the 147 476 parameters examined during the study period, 678 (0.46%) were set erroneously. At least one error occurred in 628 (3.22%) of the 19 512 treated fields. An erroneous parameter was introduced in the RVS memory in 22 (1.17%) of the 1885 fields. Conclusions: RVS has the potential to improve precision of radiation treatment delivery by detecting a significant number of setting errors. However, excessive confidence in RVS could lead to repeated errors as there is a potential for the entry of erroneous parameters into the RVS memory. [less ▲]

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See detailLe sain du Sein
Focant, Jean-François ULg

Article for general public (1999)

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See detailMid-term follow-up after multiple system organ failure following cardiac surgery in children.
Heying, R.; SEGHAYE, Marie-Christine ULg; Grabitz, R. G. et al

in Acta Paediatrica (1999), 88(11), 1238-43

Multiple system organ failure after cardiac surgery in children is a severe complication with unknown mid- and long-term sequelae. We therefore evaluated 11 children (aged 20-126 mo, median: 67 mo) having ... [more ▼]

Multiple system organ failure after cardiac surgery in children is a severe complication with unknown mid- and long-term sequelae. We therefore evaluated 11 children (aged 20-126 mo, median: 67 mo) having survived multiple system organ failure after cardiac operations for congenital cardiac defects in a cross-sectional follow-up study 12-76 mo (median: 32 mo) after surgery. Clinical and laboratory examinations included cardiac, pulmonary, renal, hepatic, neurological and psychological function tests. All patients had adequate cardiac function. Lung mechanics were abnormal in three children and glomerular renal function was abnormal in two patients. Slight elevation of gamma-glutamyl transpeptidase and coagulation factor deficiency was present in six and seven patients, respectively (five of whom had undergone the Fontan operation). Severe neurological sequelae such as diplegia (n = 1) and mental retardation (n = 1) were observed in two patients. In addition, five children presented delayed motor, graphomotor and/or speech development. Two children were found to have abnormal intelligence. We conclude that with the exception of neurological impairment, mid-term sequelae of multiple system organ failure after cardiac surgery in children are mild. However, longer follow-up using an appropriate control group is mandatory. [less ▲]

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See detailLa "culture médiatique" au XIXe siècle
Durand, Pascal ULg

in Les Dossiers de l'ORM (1999), 6

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See detailInfluence of Silicon and Aluminium Contents on the Phase Transformations During the Heat-Treatment of TRIP-assisted Multiphase Steels
Jacques, Pascal; Girault, Etienne; Mertens, Anne ULg et al

in Mideat, S. J.; Pfaffmann, G. D. (Eds.) Proceedings of the International Symposium in honor of Prof. G. Krauss, 19th Heat Treating Society Conference (1999, November)

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See detailProthèses articulaires et médecine dentaire
MAINJOT, Amélie ULg

Scientific conference (1999, November)

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See detailApproche cognitive de la mémoire de travail
Collette, Fabienne ULg

Scientific conference (1999, November)

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See detailCrise familiale et tribunal : quelle urgence pour l'expert?
Malchair, Alain ULg

in Revue Française et Francophone de Psychiatrie et de Psychologie Médicale (1999), 32

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See detailHigh Concentrations of Histamine Stimulate Equine Polymorphonuclear Neutrophils to Produce Reactive Oxygen Species
Benbarek, H.; Mouithys-Mickalad, Ange ULg; Deby-Dupont, G. et al

in Inflammation Research (1999), 48(11), 594-601

OBJECTIVE AND DESIGN: Because high concentrations of histamine are locally released in inflammation, we investigated the effects of supraphysiological doses of histamine on the production of reactive ... [more ▼]

OBJECTIVE AND DESIGN: Because high concentrations of histamine are locally released in inflammation, we investigated the effects of supraphysiological doses of histamine on the production of reactive oxygen species (ROS) by neutrophils. MATERIALS AND METHODS: Isolated equine neutrophils were activated by 10(-4) to 5 x 10(-3) M histamine. The production of ROS and free radicals was estimated by luminol-enhanced chemiluminescence (CL) and electron spin resonance (ESR) with spin trapping technique. In this model of histamine-stimulated neutrophils, we tested the antagonists of H1 and H2 histamine receptors, the role of Ca2+ and Mg2+, the role of staurosporine and pertussis toxin (inhibitors of protein kinase C and proteins G) and the effects of superoxide dismutase, catalase, hydroxyl radical scavengers (phenylalanine and mannitol) and N(G)-monomethyl-L-arginine (L-NMMA), inhibitor of NO-synthase. RESULTS: Histamine (from 10(-5) to 10(-3) M) stimulated neutrophils to produce CL and ESR signals characterized by spin adducts of superoxide anion and/or hydroxyl radicals. The CL response was inhibited by 10(-4) and 10(-3) M H1 receptor antagonists (promethazine, pyrilamine, and diphenhydramine), by Ca2+ and Mg2+ depletion and by 10 nmoles staurosporine. CL was partially inhibited by pertussis toxin (4 microg/ mL). The ESR signals were practically suppressed by pyrilamine (an H1 receptor antagonist) and superoxide dismutase, and partially inhibited by catalase, hydroxyl radical scavengers and L-NMMA (respectively 59, +/- 30% and 68% inhibition). CONCLUSIONS: High concentrations of histamine stimulated the neutrophils to product ROS and free radicals via H1 receptors and the NADPH-oxidase pathway. [less ▲]

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See detailKey-Note Speaker about: The political participation of immigrants in the formal political system
Martiniello, Marco ULg

Scientific conference (1999, October 31)

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See detailLa PME et l'entreprise familiale
Van Caillie, Didier ULg

Scientific conference (1999, October 29)

This seminar proposes a detailed overview of the basic management principles that are emerging when managing a SME and, more specifically, a family business. The importance of SMEs in the Belgian economy ... [more ▼]

This seminar proposes a detailed overview of the basic management principles that are emerging when managing a SME and, more specifically, a family business. The importance of SMEs in the Belgian economy, the role of the entrepreneur as an indiividual, the role of the family within the firm and key problems emerging in the day-to-day management of the firm are successively discussed. [less ▲]

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See detailThe field laboratory in the sugar industry
Melard, François ULg

Conference (1999, October 29)

Abstract for the thematic stream « Disciplines & Instruments » The aim of my intervention concern the implication of a scientific instrument inside an industrial context of usage. The latter takes the ... [more ▼]

Abstract for the thematic stream « Disciplines & Instruments » The aim of my intervention concern the implication of a scientific instrument inside an industrial context of usage. The latter takes the form of various little laboratories situated in the countryside. More precisely, those laboratories are generally situated in the area surronding fields and have the objective to evaluate the weight and the content of saccharose of the sugar beets deliveries ; and this for contractual purposes. The beet testing laboratories constitute a social and technical mediator by which a mode of coordination is temporarly crafted between two groups of actors : the growers and the sugar manufactuers. The instruments of measurment, and more specifically the polariscope, which compose this technological system have the interesting particularities to be submited to the contradictory supervision of both parties. Instead of just being a private place for secret industrial practices, the beet testing laboratory is widely open to public scrutiny. The perpetual negociations that take place inside the laboratories are done according to the « correct » application of a chemical protocol. In that respect, modes of visualisation are produced in order to give form to general values like efficacity, soundness or equity inside concrete procedures. The contradictory control that make the testing of sugar beets operational is conceived here as a dynamic pattern through which the reality of both a natural resource and the commited economical actors, is produced. Measurement as form of coordination is one of the central subjects in the field of the sociology of metrological practices. I will treat some aspects of industrial practices inside those beet testing laboratories in the light of the many ethnographical works done about scientific laboratories. [less ▲]

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See detailSéminaire de thèse
Grodent, Denis ULg

Scientific conference (1999, October 29)

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