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See detailAirway Mast-Cell Activation in Asthmatics Is Associated with Selective Sputum Eosinophilia
Bettiol, Jane; Radermecker, Maurice ULg; Sele, Jocelyne ULg et al

in Allergy (1999), 54(11), 1188-93

BACKGROUND: Tryptase is a serine endoprotease selectively released from mast cells. Although mast cells are known to be activated after experimental allergic provocation, their role in naturally occurring ... [more ▼]

BACKGROUND: Tryptase is a serine endoprotease selectively released from mast cells. Although mast cells are known to be activated after experimental allergic provocation, their role in naturally occurring asthma is still debated. METHODS: We have investigated the levels of tryptase in the whole induced sputum collected from 51 asthmatics (31 atopic and 20 intrinsic) seen in our outpatient clinic and 22 normal nonatopic healthy volunteers. Tryptase was measured by a new immunoassay based on B12 monoclonal antibody recognition of total tryptase (UniCAP System, Pharmacia) with a sensitivity of 1 ng/ml. RESULTS: While being below the threshold of detection in all normal volunteers, tryptase was detectable in the sputum from 9/51 asthmatics (18%) including five atopic and four intrinsic asthma cases. In these patients, among whom three were asymptomatic asthmatics, the values ranged between 1 and 6.1 ng/ml. The asthmatics with detectable sputum tryptase had greater sputum eosinophil counts (P<0.05) but lower neutrophil counts (P<0.05) than those in whom tryptase was undetectable. When compared to control subjects, asthmatics without tryptase had still greater eosinophil counts (P<0.0001) but also raised neutrophil counts (P<0.05). No significant difference could be found between asthmatics with tryptase and those without tryptase with respect to the age, the baseline lung function, the methacholine bronchial responsiveness, and the frequency of treatment with inhaled steroids. CONCLUSIONS: With the UniCAP System, tryptase was detectable in the sputum from 18% of asthmatics irrespective of atopy and current symptoms. Asthmatics with tryptase appeared to have a selective increase in sputum eosinophil counts while those without tryptase displayed a mixed sputum granulocyte infiltration with raised eosinophil and neutrophil counts. [less ▲]

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See detailRégénération osseuse: on touche au but!
Mainjot, Amélie ULg

in Journal du Dentiste, cahiers scientifiques (1999)

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See detailPourquoi et comment effectuer un renforcement musculaire excentrique ?
Croisier, Jean-Louis ULg; Crielaard, Jean-Michel ULg

in Actes du Congrès Eurokiné 1999 (1999, November)

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See detailExercices excentriques appliqués au traitement des tendinites
Forthomme, Bénédicte ULg; Croisier, Jean-Louis ULg; Foidart-Dessalle, Marguerite ULg et al

in Actes du Congrès Eurokiné 1999 (1999, November)

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See detailIdentification and Characterization of Bovine Herpesvirus Type 5 Glycoprotein H Gene and Gene Products
Meyer, Gilles; Bare, O.; Thiry, Etienne ULg

in Journal of General Virology (The) (1999), 80(Pt 11), 2849-59

Bovine herpesvirus type 5 (BHV-5) is the causative agent of a fatal meningo-encephalitis in calves and is closely related to BHV-1 which causes infectious bovine rhinotracheitis. The gene encoding BHV-5 ... [more ▼]

Bovine herpesvirus type 5 (BHV-5) is the causative agent of a fatal meningo-encephalitis in calves and is closely related to BHV-1 which causes infectious bovine rhinotracheitis. The gene encoding BHV-5 glycoprotein gH was sequenced. A high degree of conservation was found between BHV-1 and BHV-5 deduced gH amino acid sequences (86. 4%), which is also observed for all alphaherpesvirus gH sequences. Transcriptional analysis revealed a 3.1 kb mRNA as the specific gH transcript which was detected 2 h post-infection (p.i.). Twelve out of twenty-one MAbs directed against BHV-1 gH immunoprecipitated a 108-110 kDa glycoprotein, which was then designated BHV-5 gH. Synthesis and intracellular processing of BHV- 5 gH was analysed in infected MDBK cells using gH cross-reacting MAbs. Glycoprotein gH was expressed as a beta-gamma protein, detected by radioimmunoprecipitation as early as 3 h p.i. Glycosylation studies indicated that BHV-5 gH contains N-linked carbohydrates which are essential for the recognition of the protein by the MAbs. This suggests that N-linked glycans are involved in protein folding or are targets for the gH cross-reacting MAbs. Plaque- reduction neutralization assays showed that at least one BHV-1 gH antigenic domain is lacking in BHV-5 which may possibly relate to in vivo differences in virus tropism. [less ▲]

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See detailMiscibility of poly(vinylidene fluoride) and poly(methylmethacrylate-co-zinc polyacrylate) ionomers
Moussaif, Noureddin; Jérôme, Robert ULg

in Polymer (1999), 40(24), 6831-6839

A random copolymer of methyl methacrylate and 5.7 mol.% of acrylic acid has been neutralized by zinc cation to different extents in order to study the effect of zinc carboxylate pendant groups on the ... [more ▼]

A random copolymer of methyl methacrylate and 5.7 mol.% of acrylic acid has been neutralized by zinc cation to different extents in order to study the effect of zinc carboxylate pendant groups on the miscibility of poly(methyl methacrylate) (PMMA) and poly(vinylidene fluoride) (PVDF). The interaction parameter (χ) has been calculated from the experimental depression of the PVDF melting point. χ is minimum at zinc carboxylate content of 2.8 mol.%. The dynamic mechanical analysis of the PVDF-PMMA ionomer binary blends does not agree with the additivity rule of the properties, consistently with the phase morphology that changes with composition. Blends are indeed amorphous as long as the PVDF content does not exceed 40 wt.%, otherwise, semicrystalline PVDF coexists with an amorphous mixed PVDF/copolymer phase. [less ▲]

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See detailLa télédétection urbaine à l'aube de la très haute résolution spatiale
Donnay, Jean-Paul ULg; Collet, Claude; Weber, Christiane

Conference (1999, November)

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See detailLa fundación vanguardista de la traducción
Willson, Patricia ULg

in Espacios de crítica y producción (1999), (25), 54-58

This article examines and contradicts some of the stereotypes in the field of criticism about the image of Borges as translator. From the collation of his translations of works by Faulkner, Joyce and ... [more ▼]

This article examines and contradicts some of the stereotypes in the field of criticism about the image of Borges as translator. From the collation of his translations of works by Faulkner, Joyce and Woolf, the relationship between these versions and his first essays and fictions is shown, especially the ones with a «criollista» tone. [less ▲]

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See detailAge-dependence of the anticonvulsant effects of the GABA uptake inhibitor tiagabine in vitro
Sabau, A; Frahm, C; Pfeiffer, M et al

in European Journal of Pharmacology (1999), 383(3), 259-266

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See detailA scheduler for delay-based service differentiation among AF classes
Tufail, Mudassir; Jennes, Geoffroy; Leduc, Guy ULg

in Tsang, D.; Kühn, P. (Eds.) Broadband Communications - Convergence of Network Technologies (1999, November)

In the Differentiated Services (DS) framework, service differentiation is performed among the aggregates (collection of one or more microflows) rather than among the microflows (data stream pertaining to ... [more ▼]

In the Differentiated Services (DS) framework, service differentiation is performed among the aggregates (collection of one or more microflows) rather than among the microflows (data stream pertaining to a single connection). We analyse three quality metrics namely bandwidth, loss and delay (that might be used for defining a service differentiation at a DS node) on two criteria 1) service differentiation should be respected at all loads and 2) service provision at aggregate level should scale down to microflow level without being microflow aware. We find that bandwidth requires microflow aware management, loss lacks in simplicity (though it satisfies the criterion # 2), and delay is the right candidate. Ensuring better delays at an aggregate level also means ensuring better delays for all the included micro flows, and additionally it is easier to define a scheduler that can adapt itself to the relative loads of the aggregates so that relative delays between aggregate are preserved at all loads. Our objective is to provide relative quantification service in DiffServ by a delay-based scheduler while satisfying both criteria. Delay is also a meaningful QoS parameter for both interactive real-time applications and TCP applications, since the mean TCP throughput is roughly inversely proportional to the RTT. We, therefore, develop a scheduler for Assured Forwarding (AF) PHB where service differentiation among aggregates is based on delays. We provide simulation results that prove that relative delays among aggregates are perfectly respected at all loads. [less ▲]

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See detailLa “culture médiatique” au XIXe siècle. Essai de définition-périodisation
Durand, Pascal ULg

in Quaderni : la Revue de la Communication (1999)

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See detailEtude des contaminations alimentaires des produits de transformation du mil (farine et couscous) au niveau des marchés de Dakar.
Totte, A.; Mbacke Fall, S.; Bikos, A. et al

in Actes de l'Atelier International : "Les petites industries agro-alimentaire pour une nutrition saine en afrique de l'Ouest". (1999, November)

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See detailCinétique d’acidification de la farine de mil par 2 souches de Lactobacillus plantarum, une souche de Lactobacillus fermentum et Pediococcus sp.
Tine, E.; Takedam, P.; Mane, P. L. et al

in Actes de l'Atelier International : "Les petites industries agro-alimentaire pour une nutrition saine en afrique de l'Ouest" (1999, November)

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See detailLa transformation semi-industrielle des produits fermentés à base de mil au Sénégal : procédés qualité et contraintes au développement industriel.
Leite, N.; Totte, A.; Diop, M. et al

in Actes de l'Atelier International : "Les petites industries agro-alimentaire pour une nutrition saine en afrique de l'Ouest". (1999, November)

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See detailCrise familiale et tribunal : quelle urgence pour l'expert?
Malchair, Alain ULg

in Revue Française et Francophone de Psychiatrie et de Psychologie Médicale (1999), 32

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See detailAntiplatelet Activity of Clopidogrel in Coronary Artery Bypass Graft Surgery Patients
David, Jean-Louis ULg; Limet, Raymond ULg

in Thrombosis and Haemostasis (1999), 82(5), 1417-21

Clopidogrel is a recently introduced platelet ADP receptor antagonist, belonging to the thienopyridine derivatives, like its analogue ticlopidine. Its potential advantage is to be safer than ticlopidine ... [more ▼]

Clopidogrel is a recently introduced platelet ADP receptor antagonist, belonging to the thienopyridine derivatives, like its analogue ticlopidine. Its potential advantage is to be safer than ticlopidine. At 75 mg/od clopidogrel significantly inhibits platelet aggregation in ambulatory patients with symptomatic atherosclerotic disease and it prevents the recurrence of ischemic events more efficiently than aspirin. Its adequate dose in more acute situations remained to be determined. Therefore, sixty two patients with coronary artery disease were randomly assigned in four groups treated, within 24 h after coronary artery bypass graft, by clopidogrel 50 mg/od, 75 mg/od or 100 mg/od or by ticlopidine 250 mg/bid which was considered as the reference. The tolerance of clopidogrel was fairly good during the whole period of the study. Bleeding time and ex-vivo platelet aggregation induced by ADP 2 microM and 5 microM were performed at day -1, +9 and +28 after surgery. Like ticlopidine, the three dose levels of clopidogrel significantly inhibited ex-vivo platelet activity and prolonged the bleeding time at day 28. However, unlike ticlopidine, the inhibitory effects of clopidogrel were not significant at day 9, especially with 75 mg/od, a dose which was found to significantly protect patients in a chronic situation. Hence, although the clinical outcome for patients included in this limited study was the same in the four groups, these results suggest that the dose regime of clopidogrel should be more extensively investigated during the early period following coronary artery bypass graft, facing an overproduction of young and hyperreactive platelets. By analogy, the dose regime should be also investigated in other situations with an acute risk of arterial thrombotic occlusion. [less ▲]

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See detailEvaluation of frequency and type of errors detected by a computerized record and verify system during radiation treatment
Barthelemy, Nicole ULg; Sabatier, Jacques; Dewé, Walthère ULg et al

in Radiotherapy & Oncology (1999), 53(2), 149-54

Background: Computerized record and verify systems (RVS) have been introduced to improve the precision of radiation treatment delivery. These systems prevent the delivery of ionizing radiations when the ... [more ▼]

Background: Computerized record and verify systems (RVS) have been introduced to improve the precision of radiation treatment delivery. These systems prevent the delivery of ionizing radiations when the settings of the treatment machine do not match the intended parameters within some maximal authorized deviation. Purpose: To assess the potential alteration of the frequency of errors associated with the use of RVS during radiation treatment delivery. Materials and methods: The software of the RVS was altered in order to record the settings actually used for radiation treatment delivery whereas the verification function was suppressed. At the end of the study period, the settings used during daily administration of radiation treatment were compared to the parameters recorded in the RVS using the computer. They were also compared with the planned ones written in the patient treatment chart. Results: Out of the 147 476 parameters examined during the study period, 678 (0.46%) were set erroneously. At least one error occurred in 628 (3.22%) of the 19 512 treated fields. An erroneous parameter was introduced in the RVS memory in 22 (1.17%) of the 1885 fields. Conclusions: RVS has the potential to improve precision of radiation treatment delivery by detecting a significant number of setting errors. However, excessive confidence in RVS could lead to repeated errors as there is a potential for the entry of erroneous parameters into the RVS memory. [less ▲]

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See detailLe sain du Sein
Focant, Jean-François ULg

Article for general public (1999)

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