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See detailThe diversity, structure and regulation of beta-lactamases.
Philippon, A; Dusart, Jean; Joris, Bernard ULg et al

in Cellular and Molecular Life Sciences : CMLS (1998), 54(4), 341-6

beta-Lactamase production is responsible for the appearance of a large number of pathogenic bacterial strains exhibiting a high degree of resistance to beta-lactam antibiotics. A large number of enzymes ... [more ▼]

beta-Lactamase production is responsible for the appearance of a large number of pathogenic bacterial strains exhibiting a high degree of resistance to beta-lactam antibiotics. A large number of enzymes have been described with very diverse primary structures and catalytic profiles. Nevertheless, all known three-dimensional structures of active-site serine beta-lactamases exhibit a high degree of similarity with apparently equivalent chemical functionalities in the same strategic positions. These groups might not, however, play identical roles in the various classes of enzymes. Structural data have also been recently obtained for the zinc metallo-beta-lactamases, but the detailed catalytic mechanisms might also differ widely, depending on the enzyme studied. Similarly, the induction of the synthesis of beta-lactamases is now better understood, but many questions remain to be answered. [less ▲]

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See detailProduction de molécules à note verte par synthèse enzymatique.
Malanda, Nelawu; Marlier, Michel; Fauconnier, Marie-Laure ULg

Report (1998)

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See detailCompte rendu de Le geste et les gestes au Moyen Age. Aix-en-Provence, 1998
George, Philippe ULg

in Moyen Age (Le) (1998)

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See detailAdverse effect of hyperinsulinemia on cardiovascular risk profile in middle-aged belgian population
Saint-Remy, Annie ULg; Scheen, André ULg; Jeanjean, Michel et al

in Acta Cardiologica (1998), 53(5), 299

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See detail(E)-2'-Deoxy-2'-(Fluoromethylene)cytidine potentiates radioresponse of two human solid tumor xenografts.
Sun, L-Q; Li, Y-X; Guillou, L et al

in Proceedings of the American Association for Cancer Research (1998)

Antitumor and radiosensitizing effects of (E)-2'-deoxy-2'-(fluoromethylene) cytidine (FMdC), a novel inhibitor of ribonucleotide reducÃase, were evaluated on nude mice bearing s.c. human C33-A cervix ... [more ▼]

Antitumor and radiosensitizing effects of (E)-2'-deoxy-2'-(fluoromethylene) cytidine (FMdC), a novel inhibitor of ribonucleotide reducÃase, were evaluated on nude mice bearing s.c. human C33-A cervix cancer and I -H7 MG glioblastoma xenografts. FMdC given once daily has a dosedependent antitumor effect. The maximum tolerated dose in the mice was reached with 10 daily i.p. administrations of 10 mg/kg over 12 days. In the case of radiotherapy (RT) alone (10 fractions over 12 days), the radiation dose required to produce local tumor control in 50% of the treated C33-A xenografts was 51.0 Gy. When combined with FMdC, the radiation dose required to produce local tumor control was reduced to 41.4 and 38.2 Gy, at respective doses of 5 and 10 mg/kg given i.p. l h before each irradiation. The corresponding enhancement ratios (ERs) were 1.2 and 1.3, respec tively. In U-87 MG xenografts, when 5-20 mg/kg FMdC combined with 30 or 40 Gy of RT, the combination treatment produced a significantly increased growth delay as compared with RT alone (P £0.002). The ERs of 5, 10, and 20 mg/kg FMdC at a dose of 30 Gy were 2.0, 1.4, and 1.8, respectively. At the 40-Gy level, ERs of 10 and 20 mg/kg FMdC were 1.4 and 1.7. When FMdC was combined with 50 Gy of RT, an increased long-term remission rate of 80-88.9% was observed, as compared with 25% for RT alone (P <0.05). FMdC produced moderate myelosuppression in the mice bearing cervix cancer, whereas leukocytosis occurred in the mice bearing glioblastoma at a low dose. Slightly increased skin toxicity (only with U-87 MG tumor) was observed, as compared with RT alone. In conclusion, FMdC is a potent cytotoxic agent and able to modify the radiation response of C33-A and U-87 MG xenografts. [less ▲]

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See detailAnalyse du secteur de la viande bovine en Belgique et impacts de la crise de la "vache folle", notamment sur les prix du marché intérieur et à l'exportation
Moutteau, M.; Burny, Philippe ULg; Lebailly, Philippe ULg

in Institut National de la Recherche Agronomique (Ed.) 56ème Séminaire de l'Association Européenne des Economistes Agricoles "L'avenir à long terme du secteur de la viande bovine" : actes du colloque (1998)

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See detailL'évolution de l'économie agricole et horticole de la région wallonne 1997
Burny, Philippe ULg; Lebailly, Philippe ULg

Book published by Conseil supérieur wallon de l'Agriculture, de l'Agro-alimentaire et de l'Alimentation (1998)

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See detailIntérêt de l'évaluation fonctionnelle du patient lombalgique fréquentant une école du dos
Vanderthommen, Marc ULg; Drosson, C.; TOMASELLA, Marco ULg et al

in Kiné Acta-Symposium (1998)

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See detailAb initio phonon dispersion curves and interatomic force constants of barium titanate
Ghosez, Philippe ULg; Gonze, X.; Michenaud, J. P.

in Ferroelectrics (1998), 206(1-4), 205-217

The phonon dispersion curves of cubic BaTiO3 have been computed within a first-principles approach and the results compared to the experimental data. The curves obtained are very similar to those reported ... [more ▼]

The phonon dispersion curves of cubic BaTiO3 have been computed within a first-principles approach and the results compared to the experimental data. The curves obtained are very similar to those reported for KNbO3 by Yu and Krakauer (Phys. Rev. Lett., 74, 4067 (1995)). They reveal that correlated atomic displacements along [100] chains are at the origin of the ferroelectric instability. A simplified model illustrates that spontaneous collective displacements will occur when a dozen of aligned atoms are coupled. The longitudinal interatomic force constant between nearest neighbour Ti and O atoms is relatively weak in comparison to that between Ti atoms in adjacent cells. The small coupling between Ti and O displacements seems however necessary to reproduce a linear ferroelectric instability. [less ▲]

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See detailTextural properties of pressure-induced gels of food proteins obtained under different temperatures including zero
Dumoulin, Mireille ULg; Osawa, S.; Hayashi, Rikimaru

in Journal of Food Science (1998), 63

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See detailFeature Selection and Extraction
Verly, Jacques ULg

Scientific conference (1998)

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See detailThe use of Triton X-100 for the incorporation of BrUTP allows a specific labeling of nucleolar or extranucleolar transcription
Nizet, S; Thiry, Marc ULg; Goessens, G

in Cell Biology International (1998), 22

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See detailA cognitive neuropsychological approach to spatial memory deficits in brain-damaged patients
Van der Linden, Martial ULg; Meulemans, Thierry ULg

in Foreman, N. (Ed.) Handbook of spatial research paradigms and methodologies. Vol. 2 (1998)

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See detailSynthesis of Tetraalkyl(Pyrrolidine-2,2-diyl)bisphosphonates and 2,2-Bis(diethoxyphosphoryl)-3,4-dihydro-2H-pyrrole 1-Oxide; ESR Study of Derived Nitroxides
Olive, Gilles ULg; Le Moigne, François; Mercier, Anne et al

in Journal of Organic Chemistry (1998), 63(24), 9095-9099

Synthesis of Tetraalkyl (Pyrrolidine-2,2-diyl)bisphosphonates and 2,2-Bis(diethoxyphosphoryl)-3,4-dihydro-2Hpyrrole 1-Oxide; ESR Study of Derived Nitroxides

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See detailLa recherche et l'agriculture de demain
Burny, Philippe ULg

Conference given outside the academic context (1998)

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See detailMRI of a presumptive trigeminal nerve tumor in a seven years old husky dog : a case report and review of the litterature
Saunders, J.; Clercx, Cécile ULg; Poncelet, Luc et al

in Veterinary Radiology & Ultrasound (1998), 39

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See detailLe rôle du lithium dans la structure type alluaudite
Hatert, Frédéric ULg; Antenucci, Diano ULg

Conference (1998)

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See detailFine structure of the larvae of the Myzostoma cirriferum (Myzostomida)
Eeckaut, I.; Fievez, Laurence ULg; Jangoux, M.

Poster (1998)

Adults of Myzostoma cirriferum are obligate ectocommensals that live on the surface of comatulids of the genus Antedon from the North East Atlantic and Mediterranean. M. cirriferum is a simultaneous ... [more ▼]

Adults of Myzostoma cirriferum are obligate ectocommensals that live on the surface of comatulids of the genus Antedon from the North East Atlantic and Mediterranean. M. cirriferum is a simultaneous hermaphrodite which reproduces by transferring spermatophores that penetrate the integument of the receiver myzostomes. Fertilized eggs are shed into the water column where they divide. After the embryonic stage that lasts 24h, the motile individuals enter into the larval stage. Three types of larvae are recognized in M. cirriferum: the spherical protrochophora (occuring between 24 and 48h after the laying), the pyriform trochophora (48-72h), and the pyriform, setigerous metatrochophora (72h until metamorphosis). The body of the protrochophora and trochophora is made of undifferenciated cells and ciliated cells. Two types of undifferentiated cells are present: the first contact the thin cuticle, have microvilli and include a lot of yolk droplets; the second are internal and have no or only a few yolk droplets. No basal lamina has been observed in the body of these larvae. Huge tissular modifications occur in the young metatrochophora (i.e. 96-144h after laying). The epidermis is now well underlined by a basal lamina. Two pairs of 4 chaetae lie on the sides of the larval body and a sensory caudal appendage is differentiating at its end. The digestive system is forming. It is composed of a pharynx included in an extensible introvert and a closed, internal digestive cavity. The nervous system appears and is composed of an epispheral nervous mass, a peripharyngeal collar, nervous processes and sensory cells. The anatomy of the late metatrochophora stays unchanged until metamorphosis, which generally occurs 7 days after laying. The body of the larva is made of twelve cell types. Seven are ectodermal: covering cells and ciliated cells make up most of the epidermis; primary chaetoblasts and lateral cells form the chaetal follicles; secondary chaetoblasts will build the chaetae of juveniles after metamorphosis; pharyngeal cells and myoepithelial cells make up the pharyngeal epithelium. The other cell types are neurodermal (neurons and sensory cells), endodermal (the digestive cells that border the digestive cavity) and mesodermal (parenchyma cells and muscle cells) [less ▲]

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