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See detailPatterns of the Immunohistochemical Expression of Melanoma-Associated Antigens and Density of Cd45r0+ Activated T Lymphocytes and L1-Protein Positive Macrophages in Primary Cutaneous Melanomas
Pierard-Franchimont, Claudine ULg; Letawe, C.; Nikkels, Arjen ULg et al

in International Journal of Molecular Medicine (1998), 2(6), 721-724

There is ample evidence for spontaneous antimelanoma immune reactivity mediated by melanocyte-differentiation-antigens (MDAs). Our aim was to determine whether MDA immunoreactivity is associated with ... [more ▼]

There is ample evidence for spontaneous antimelanoma immune reactivity mediated by melanocyte-differentiation-antigens (MDAs). Our aim was to determine whether MDA immunoreactivity is associated with increased tumour-infiltrating lymphocytes (TIL) and macrophages (TIM). A retrospective study was conducted in 30 medium and high grade primary cutaneous melanomas (PCM) as identified by CART-analysis. All of the cases had developed clinical evidence for metastasis within 3 years following surgical excision of the PCM. We used immunohistochemistry and computerized image analysis to quantify MDAs positive cells (Melan A/MART-1, gp100/Pmel 17/HMB45, tyrosinase), CD45R0-positive TIL and LI-protein-positive TIM. A stochastic relationship was present between the MDA immuno-reactivities and the densities in TIL and TIM. An inverse relationship was yielded between TIL and TIM. No specific pattern of PCM immunoreactivity for MDAs, TIL and TIM was found to predict metastases. [less ▲]

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See detailHystéroscopie opératoire ou hystérectomie dans le traitement des lésions utérines bénignes. Que choisir en 1998?
Herman, Philippe ULg; Gaspard, Ulysse ULg; Foidart, Jean-Michel ULg

in Revue Médicale de Liège (1998), 53(12), 756-61

In the past, the treatment of benign uterine lesions required, in many instances, a hysterectomy. These days, most cases can be successfully treated by hysteroscopy. To be reliable, this technique must ... [more ▼]

In the past, the treatment of benign uterine lesions required, in many instances, a hysterectomy. These days, most cases can be successfully treated by hysteroscopy. To be reliable, this technique must lead to a significant reduction in the number of hysterectomies performed for benign uterine lesions. The electroresection technique is preferred to that using the Nd-YAG laser because of its lower cost and its equivalent efficacy. By using the uterine perfusion pump device, the risk of resorption syndrome can be reduced to its minimum. Submucosal myomas < 1 cm, benign endometrial hyperplasia and adenomyosis are the commonest benign lesions treated. Dysfunctional uterine bleeding can also be treated by an endometrectomy. A preoperative workup includes a transvaginal ultrasound and a biopsy. This ensures that only benign lesions that are accessible to a hysteroscopy will be submitted to this technique and that no cases of endometrial cancer or atypical hyperplasia would be ignored. This study presents 270 cases of operative hysteroscopy with a follow-up to 4 years. 82.8% of myomatous lesions were treated with success. The results for patients with benign endometrial polyps or benign endometrial hyperplasia are also excellent with only 4.6% and 5.6% rate of secondary surgery respectively. Adenomyosis does not appear to be a good indication for hysteroscopy as only 37% of patients did not need a definitive hysterectomy. Rates of operative complications (post-operative bleeding, uterine perforation, resorption syndrome and difficulty of access) are acceptable and get less frequent as the surgeon experience increases. [less ▲]

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See detailLe cinéma documentaire en Belgique francophone aujourd'hui
Van Cauwenberge, Geneviève ULg

in Revue Nouvelle (1998), 12

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See detailChlorophyll Synthesis in Dark-Grown Pine Primary Needles
Schoefs, B.; Franck, Fabrice ULg

in Plant Physiology (1998), 118(4), 1159-68

The pigment content of dark-grown primary needles of Pinus jeffreyi L. and Pinus sylvestris L. was determined by high-performance liquid chromatography. The state of protochlorophyllide a and of ... [more ▼]

The pigment content of dark-grown primary needles of Pinus jeffreyi L. and Pinus sylvestris L. was determined by high-performance liquid chromatography. The state of protochlorophyllide a and of chlorophylls during dark growth were analyzed by in situ 77 K fluorescence spectroscopy. Both measurements unambiguously demonstrated that pine primary needles are able to synthesize chlorophyll in the dark. Norflurazon strongly inhibited both carotenoid and chlorophyll synthesis. Needles of plants treated with this inhibitor had low chlorophyll content, contained only traces of xanthophylls, and accumulated carotenoid precursors. The first form of chlorophyll detected in young pine needles grown in darkness had an emission maximum at 678 nm. Chlorophyll-protein complexes with in situ spectroscopic properties similar to those of fully green needles (685, 695, and 735 nm) later accumulated in untreated plants, whereas in norflurazon-treated plants the photosystem I emission at 735 nm was completely lacking. To better characterize the light-dependent chlorophyll biosynthetic pathway in pine needles, the 77 K fluorescence properties of in situ protochlorophyllide a spectral forms were studied. Photoactive and nonphotoactive protochlorophyllide a forms with emission properties similar to those reported for dark-grown angiosperms were found, but excitation spectra were substantially red shifted. Because of their lower chlorophyll content, norflurazon-treated plants were used to study the protochlorophyllide a photoreduction process triggered by one light flash. The first stable chlorophyllide photoproduct was a chlorophyllide a form emitting at 688 nm as in angiosperms. Further chlorophyllide a shifts usually observed in angiosperms were not detected. The rapid regeneration of photoactive protochlorophyllide a from nonphotoactive protochlorophyllide after one flash was demonstrated. [less ▲]

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See detailManagement of Fulminant Hepatic Failure
Detry, Olivier ULg; Honore, Pierre ULg; Meurisse, Michel ULg et al

in Acta Chirurgica Belgica (1998), 98(6), 235-40

Fulminant hepatic failure is an infrequent but dreadful disease, occurring usually in young patients. Despite fulminant hepatic failure is reversible in most of the cases, some patients develop brain ... [more ▼]

Fulminant hepatic failure is an infrequent but dreadful disease, occurring usually in young patients. Despite fulminant hepatic failure is reversible in most of the cases, some patients develop brain edema and intracranial hypertension, which are the most common cause of death in these patients. Liver transplantation significantly improves the prognosis of selected patients in who precise criteria predict a low chance of survival. This review summarizes the modern standard of care of patients with fulminant hepatic failure, with particular underlining of the management of brain oedema and intracranial hypertension. [less ▲]

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See detailEnantiomeric Separation of Pirlindole by Liquid Chromatography Using Different Types of Chiral Stationary Phases
Ceccato, Attilio ULg; Hubert, Philippe ULg; De Tullio, Pascal ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (1998), 18(4-5), 605-14

The enantioseparation of pirlindole by liquid chromatography (LC) was investigated using three different chiral stationary phases (CSPs) containing either cellulose tris-(3,5-dimethylphenylcarbamate ... [more ▼]

The enantioseparation of pirlindole by liquid chromatography (LC) was investigated using three different chiral stationary phases (CSPs) containing either cellulose tris-(3,5-dimethylphenylcarbamate) (Chiralcel OD-R), ovomucoid (OVM) or beta-cyclodextrin (beta-CD). The effects of the mobile phase pH on retention, enantioselectivity and resolution were studied. Methanol and acetonitrile were tested as organic modifiers while the influence of the addition to the mobile phase of sodium alkanesulfonates or sodium perchlorate was also investigated. Sodium perchlorate was only used on the Chiralcel OD-R column while sodium alkanesulfonates were tested as mobile phase additives on the three kinds of CSPs. The enantioseparation of pirlindole could be obtained on all CSPs tested, the best results with respect to chiral resolution being achieved on the Chiralcel OD-R and the OVM columns. The use of sodium octanesulfonate (NaOS) was found to improve the enantioseparation of pirlindole on the OVM column while enantioselectivity was considerably enhanced by addition of sodium perchlorate on the Chiralcel OD-R column. [less ▲]

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See detailThe importance of being small
Tharakan, Joseph ULg

Conference (1998, December)

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See detailSpontaneous Apamin-Sensitive Hyperpolarizations in Dopaminergic Neurons of Neonatal Rats
Seutin, Vincent ULg; Massotte, Laurent ULg; Scuvée-Moreau, Jacqueline ULg et al

in Journal of Neurophysiology (1998), 80(6), 3361-4

Spontaneous apamin-sensitive hyperpolarizations in dopaminergic neurons of neonatal rats. J. Neurophysiol. 80: 3361-3364, 1998. Intracellular recordings from substantia nigra slices revealed the existence ... [more ▼]

Spontaneous apamin-sensitive hyperpolarizations in dopaminergic neurons of neonatal rats. J. Neurophysiol. 80: 3361-3364, 1998. Intracellular recordings from substantia nigra slices revealed the existence of spontaneous hyperpolarizations (amplitude 2-8 mV, duration 100-400 ms) at -60 mV in most dopaminergic neurons of neonatal (9-15 days) but not adult rats. These events were blocked by apamin (300 nM) and bicuculline methochloride (100-300 microM), which blocks apamin-sensitive currents. They were unaffected by the selective gamma-aminobutyric acid-A (GABAA) antagonists SR95531 (100 microM) and picrotoxin (30-50 microM), the GABAB antagonist CGP35348 (300 microM), the D2 antagonist haloperidol (1 microM), and the metabotropic antagonist MCPG (1 mM). The hyperpolarizations were strongly attenuated or abolished when recording electrodes contained 200 mM 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid. They were resistant to tetrodotoxin in the majority of the cells. They had some voltage dependency and were in some cases transiently potentiated when cells were briefly depolarized by current injection. We conclude that dopaminergic neurons have developmentally regulated physiological properties. These spontaneous hyperpolarizations might affect the firing rate of these cells, which was found to be lower in neonates than in adults. [less ▲]

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See detailGonarthrose: intérêt de l'évaluation isocinétique
Croisier, Jean-Louis ULg; Henrotin, Yves ULg; Dumont, R. et al

in KINE 2000 (1998, December), 9(98/5), 90

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See detailMesures de déplacements et de déformations de la cathédrale de Tournai
Sine, Bernard; Latteur, Pierre ULg

Article for general public (1998)

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See detailElectrochemically synthesized polypyrrole nanotubules : effects of different experimental conditions
Demoustier-Champagne, Sophie; Ferain, Etienne; Jérôme, Christine ULg et al

in European Polymer Journal (1998), 34(12), 1767-1774

Nanotubules of polypyrrole (PPy) were electrochemically synthesized using the pores of nanoporous polycarbonate (PC) particle track-etched membranes (PTM) as templates. The influence of some conditions of ... [more ▼]

Nanotubules of polypyrrole (PPy) were electrochemically synthesized using the pores of nanoporous polycarbonate (PC) particle track-etched membranes (PTM) as templates. The influence of some conditions of electrosynthesis (electrochemical method, monomer concentration, electrolyte concentration and nature) on the kinetics of pyrrole electropolymerization and on the morphology of the obtained nanomaterials has been investigated. In particular, the empirical kinetics of the electrochemical generation of polypyrrole-perchlorate (PPy-ClO4) from aqueous solution, at 0.8 V (vs SCE) was followed by electrical charges measurement. The orders with respect to pyrrole and LiClO4 are 0.34 and 0.70 respectively. The electrogeneration of polypyrrole-polystyrenesulfonate (PPy-PSS) was also followed and shows that an increase of the electrolyte concentration increases the polymerization rate at constant potential. Finally, the morphology of PPy nanotubules doped with LiClO4 and NaPSS has been studied by high resolution emission SEM and by TEM. [less ▲]

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See detailManagement of Recipients of Hepatic Allografts Harvested from Donors with Malignancy Diagnosed Shortly after Transplantation
Detry, Olivier ULg; Honore, Pierre ULg; Jacquet, Nicolas et al

in Clinical Transplantation (1998), 12(6), 579-81

Transmission of undiagnosed malignancy with the graft is a dramatic complication of liver transplantation. Alternatives in the management of the recipients of livers, harvested from donors with malignancy ... [more ▼]

Transmission of undiagnosed malignancy with the graft is a dramatic complication of liver transplantation. Alternatives in the management of the recipients of livers, harvested from donors with malignancy diagnosed shortly after transplantation, are either early re-transplantation or close follow-up without re-operation. We reported 4 cases of liver recipients whose allografts were harvested from donors who were diagnosed with malignancy shortly after the liver transplantation. One recipient underwent re-transplantation, and the three other allografts were not removed. No recipient developed recurrence in the follow-up. While graft removal may be the only way to avoid tumor recurrence in recipients of liver graft harvested from donor with malignancy, close follow-up without re-operation may also be considered. The risk of tumor transferral may depend on the histopathological aggressiveness and metastatic potential of the donor tumor, and may be low for low-grade, local tumors. This risk should be evaluated by analyzing large series, using databases of Eurotransplant or United Network for Organ Sharing. [less ▲]

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See detailRecent developments in anionic polymerization
Jérôme, Robert ULg; Tong, Jiangdong

in Current Opinion in Solid State and Materials Science (1998), 3(6), 573-578

The past year witnessed very significant advances in the living anionic polymerization of (meth)acrylate monomers, particularly in hydrocarbons at or below 0°C. Block polymerization of alkyl methacrylates ... [more ▼]

The past year witnessed very significant advances in the living anionic polymerization of (meth)acrylate monomers, particularly in hydrocarbons at or below 0°C. Block polymerization of alkyl methacrylates with primary alkyl acrylates, although somewhat improved, remains a challenge. Anionic polymerization of styrene, diene and its derivatives was carried out with the aim of synthesizing functional polymers and block copolymers of various architectures. There has been a trend towards combining different living techniques in order to design polymers of unique architectures and properties. [less ▲]

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See detailTransplantation hépatique: expérience et résultats du programme de l'Université de Liège
Honore, Pierre ULg; Detry, Olivier ULg; Meurisse, Michel ULg et al

in Revue Médicale de Liège (1998), 53(12), 735-7

The orthotopic liver transplantation (OLT) program of the University of Liege was initiated in 1986. Between 1986 and December 1998, 150 adult OLT have been performed in our institution, including 18 ... [more ▼]

The orthotopic liver transplantation (OLT) program of the University of Liege was initiated in 1986. Between 1986 and December 1998, 150 adult OLT have been performed in our institution, including 18 liver retransplantations, 1 combined heart and liver transplantation and 3 combined liver and kidney transplantations. The aim of this study was to report the last 3 years of our experience. From January 1996 to November 1998, we performed 50 OLT on 49 patients. Three were retransplantations and two were combined liver and kidney transplantations. Fourty-three patients were transplanted for chronic liver disease and 6 for acute or subacute hepatopathy. Mean waiting time on the list was 4 weeks. Immunosuppression was based on triple therapy (cyclosporin A/tacrolimus, steroids, azathioprine), with steroid and azathioprine withdrawal in most of the patients after 3 months. In the chronic liver disease group, operative (< 30 days) survival was 95% (peroperative myocardial infarction in 2 patients). In the acute liver disease group, postoperative survival was 66%. No perioperative death occurred in 1997 and 1998. Actuarial one year survival was 87%. In our experience, OLT has become a safe procedure. [less ▲]

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See detailSimulation de l'usinage : essais de fraisage
Masset, Luc ULg; Debongnie, Jean-François ULg

Report (1998)

This report describe milling tests which have been done and their comparison to computational results. In order to obtain significant form defects, a very flexible work has been used. Difficulties arose ... [more ▼]

This report describe milling tests which have been done and their comparison to computational results. In order to obtain significant form defects, a very flexible work has been used. Difficulties arose in the primary machining of the workpiece, due to residual stresses. A more efficient machining scheme has then be defined for this step. In order to avoid complications coming from the multiplicity of the teeth of the milling tool, fly-dressing has been considered. The results are discussed in detail. [less ▲]

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See detailCoupling thermal simulation and airflow calculation for a better evaluation of natural ventilation strategies
Andre, Philippe ULg; Kummert, M.; Nicolas, Jacques ULg

in Proceedings SSB'98 (1998, December)

A lot of building simulation tools are available today on the market. Most of them rely on very simplified hypotheses concerning the appraisal of airflows: very often, a constant (userdefined) airflow is ... [more ▼]

A lot of building simulation tools are available today on the market. Most of them rely on very simplified hypotheses concerning the appraisal of airflows: very often, a constant (userdefined) airflow is supposed, either to quantify the infiltration rate of a building or to estimate the coupling coefficients between zones. On the other hand, some recent tools become available to calculate air flow couplings between the different zones of a building or between a building and its environment. Those tools rely on simplified hypotheses concerning the temperatures distribution in a building. From that observation, it is obvious that a strong complementarity exists between both categories of tools. Several methods are available to perform this coupling and they are briefly described in the paper. Then, one of these methods is considered in details and successly engineered for the global simulation of two Case Studies of the IEA Annex 30 project: an office building in Germany and an appartment building in Poland. Both applications show the relevancy of the coupling process and the impressive impact on some simulation results. A parametric analysis of some key variables is also performed. As a conclusion, the paper identifies the limitations of the coupling method which is used in this case and proposes some improvements based upon an increase of the automization and integration process. [less ▲]

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See detailIEA Annex 30 : bringing simulation to application. Conclusions of subtask 1 : model qualification
Andre, Philippe ULg; Bourdouxhe, J.-P.; Lebrun, Jean ULg

in Proceedings of SSB'98 (1998, December)

From 1995 to 1998, IEA Annex 30 "Bringing Simulation to Application" has been adressing the problem of improving the conditions aiming at a more effective use of building and HVAC simulation among ... [more ▼]

From 1995 to 1998, IEA Annex 30 "Bringing Simulation to Application" has been adressing the problem of improving the conditions aiming at a more effective use of building and HVAC simulation among consulting engineers and building practitioners. Therefore, the project gathered both academic research teams and several consulting offices representatives in order to demonstrate, on real Case Studies, what should be done to achieve this goal. The first Subtask of the IEA Annex 30 was dealing with the most fundamental step appearing in the process of simulation use: qualification of the models implemented in the available simulation tools. The objective of the Subtask was to establish a framework allowing any simulation models developper to provide the necessary information making any simulation model user more confident when using such tools. To achieve this objective, Subtask 1 was divided in two parts: - a first part dealing with a survey of the available models and data resources useful for building and HVAC simulation; - a second part dealing with the development and the application on several examples of "model qualification procedures", which provides the required framework. The survey action was mainly focussing on the following items: models, meteorological data, internal gains, HVAC and material databases. The model qualification procedure was first defined as a sequence of operations involving several steps: model documentation, parameters identification, examples of use and sample results, validation (or verification of the models), integration in a data exchange process. This procedure was applied to several building and HVAC models: building thermal zones, cooling coil, chiller and cooling tower. [less ▲]

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See detailPurification and Characterization of a 315 Kda Keratinolytic Subtilisin-Like Serine Protease from Microsporum Canis and Evidence of Its Secretion in Naturally Infected Cats
Mignon, Bernard ULg; Swinnen, M.; Bouchara, J. P. et al

in Medical Mycology (1998), 36(6), 395-404

A keratinolytic protease, secreted as the major component by a feline clinical isolate of Microsporum canis cultivated in a minimal medium containing cat keratin, was purified by affinity chromatography ... [more ▼]

A keratinolytic protease, secreted as the major component by a feline clinical isolate of Microsporum canis cultivated in a minimal medium containing cat keratin, was purified by affinity chromatography on bacitracin agarose and gel filtration. The apparent molecular mass of the enzyme was 31.5 kDa and the pI was 11.8. The enzyme was not glycosylated and its first 15 N-terminal amino acids showed numerous similarities with other fungal subtilisins. The optimum pH was around 9 while inactivation of the enzyme was reversible at pH 4, but not at pH 11. The enzyme was stable at 37 degrees C with an apparent optimum temperature around 55 degrees C. PMSF, soybean trypsin inhibitor (SBTI) and chymostatin strongly inhibited the proteinase. The highest affinity (Km of 0.37 mM) and physiological efficiency (k(cat)/Km) were obtained for the synthetic substrate N-Suc-Ala-Ala-Pro-Phe-p-nitroanilide. These results indicate that the keratinase belongs to the subtilisin-like serine protease family. Purified rabbit immunoglobulins G prepared against the keratinase and used in an immunohistochemical test allowed the detection of the keratinase produced by the fungus invading hair structures in naturally infected cats. The in vitro keratinolytic activity of the enzyme and its production in vivo suggest that it may contribute to pathogenicity. [less ▲]

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See detailDe quelques complexes, obsessions et refoulements en didactique du français langue étrangère et seconde
Defays, Jean-Marc ULg

in Langage et l'Homme (Le) : Recherches Pluridisciplinaires sur le Langage (1998), XXXIII(4), 451-463

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See detailEffects of Regular Insulin or Insulin Lispro on Glucose Metabolism after an Oral Glucose Load in Patients with Type 2 Diabetes Mellitus
Paquot, Nicolas ULg; Roulin, D.; Schneiter, P. et al

in Diabètes & Métabolism (1998), 24(6), 523-8

Seven obese Type 2 diabetic patients were studied for two 4-h periods after ingestion of a glucose load to determine the effects of preprandial subcutaneous injection of Insulin Lispro (5 min before the ... [more ▼]

Seven obese Type 2 diabetic patients were studied for two 4-h periods after ingestion of a glucose load to determine the effects of preprandial subcutaneous injection of Insulin Lispro (5 min before the meal) or regular insulin (20 min before the meal) on glucose metabolism. Glucose production and utilisation were measured using a dual isotope method. After Lispro, the mean postprandial increase in plasma glucose was 29% lower and the increase in insulin concentration 25% higher than after regular insulin (p < 0.05). Suppression of endogenous glucose production was similar with both types of insulin. Thus, preprandial injection of Lispro reduced postprandial glucose increments in Type 2 diabetic patients as compared to regular insulin. This effect is best explained by the increased postprandial bioavailability of Lispro. [less ▲]

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