La résistance bactérienne aux antibiotiques, un modèle exemplaire d'évolution moléculaire dirigée.
in Revue Médicale de Liège (1998), 53(9), 529-531
The simplest conceivable event that can occur at the gene level can result in the development of efficacious resistance tot antibiotics. The bacterial world behaves as an enormous organism whose cells can ... [more ▼]
The simplest conceivable event that can occur at the gene level can result in the development of efficacious resistance tot antibiotics. The bacterial world behaves as an enormous organism whose cells can exchange their genes very easily. Accordingly, oppotunities for the exhcange of genetic material in nature are probably unlimited. This knowledge cannot be ignored. It leads to the important conclusion that the antibiotics are societal drugs. A resistance gene which has appeared somewhere in the world can travel far and fast. [less ▲]Detailed reference viewed: 31 (3 ULg)
Effects of Dobutamine on Isovolumic and Ejection Phase Indices of Cardiac Contractility in Conscious Healthy Dogs
Mc Entee, Kathleen ; Amory, Hélène ; et al
in Research in Veterinary Science (1998), 64(1, Jan-Feb), 45-50
The aim of this study was to determine cardiac contractility using indices derived from cardiac catheterisation in conscious healthy dogs during dobutamine infusion. Eight dogs were studied. An ECG was ... [more ▼]
The aim of this study was to determine cardiac contractility using indices derived from cardiac catheterisation in conscious healthy dogs during dobutamine infusion. Eight dogs were studied. An ECG was recorded together with left ventricular pressure and volume which were measured using a conductance catheter with an integrated microtip pressure sensor. Eight indices of left ventricular systolic performance were derived from these records. Measurements were realised under basal conditions and during an incremental dobutamine challenge. The maximal rate of rise in ventricular pressure (max dP/dt), max dP/dt divided by the developed pressure and the mean systolic ejection rate were the most sensitive indices to detect dobutamine induced changes in contractility with maximal percentage changes of 122+/-11 per cent, 130+/-7 per cent and 102+/-24 per cent respectively. Ejection fraction increased significantly during dobutamine infusion (maximal percentage change of 43+/-9 per cent) whereas the pre-ejection period (PEP) and the left ventricular ejection time (LVET) decreased significantly (maximal percentage change of -41+/-2 per cent and -28+/-3 per cent respectively). All these six indices were significantly correlated with each other. Conversely, the ratio PEP/LVET and the LVET corrected for heart rate dependency showed a maximal percentage change of only -10+/-1 per cent and -16+/-7 per cent, respectively, during the dobutamine infusion and were not significantly correlated with the other contractility indices. This study demonstrated the feasibility of the conductance method to determine cardiac contractility in conscious healthy dogs submitted to a pharmacological stress testing and provides control values for eight indices of left ventricular contractility during dobutamine infusion at increasing dosages. [less ▲]Detailed reference viewed: 18 (3 ULg)
Evidence for behavioral sensitization to cocaine in preweanling rat pups
; Tirelli, Ezio ; et al
in Psychopharmacologia (1998), 138(2), 114-123
Sought to determine whether promoting context-dependent sensitization might facilitate expression of sensitization in preweanlings. Sprague-Dawley rats were injected daily from postnatal day 14 to ... [more ▼]
Sought to determine whether promoting context-dependent sensitization might facilitate expression of sensitization in preweanlings. Sprague-Dawley rats were injected daily from postnatal day 14 to postnatal day 20 with 0, 5, 15, or 30 mg/kg cocaine hydrochloride and placed for 30 min in either the experimental chamber or home cage. On postnatal day 21 (test day), Ss were challenged with either 15 mg/kg cocaine or saline prior to placement in the experimental chamber. Significant sensitization of cocaine-induced stereotyped head movements was evident in animals given 15 or 30 mg/kg chronically in the experimental chamber, but not when these same doses were given in the home cage. Less consistent evidence for cocaine-induced sensitization was seen when examining locomotion, although trends for sensitization of this behavior were seen in animals chronically injected in either the test chamber or home cage. Thus, preweanlings can exhibit cocaine sensitization, particularly in terms of stereotypy, when tested shortly after the chronic exposure period, with expression of this sensitization being facilitated by pairing the chronic injections with the test context. ((c) 1998 APA/PsycINFO, all rights reserved) [less ▲]Detailed reference viewed: 11 (1 ULg)
Le Robinier faux acacia.
in Courrier du Bois (1998), 38(120), 13-20
Le Robinier est une essence méconnue en Belgique dont l’emploi se limite bien souvent à la fixation des talus ou à l’ornementation des parcs et avenues. Cette espèce présente, cependant, de multiples ... [more ▼]
Le Robinier est une essence méconnue en Belgique dont l’emploi se limite bien souvent à la fixation des talus ou à l’ornementation des parcs et avenues. Cette espèce présente, cependant, de multiples caractéristiques susceptibles de rencontrer un grand intérêt auprès des sylviculteurs et des utilisateurs de bois. [less ▲]Detailed reference viewed: 55 (3 ULg)
Effect of Ketoprofen on Paf-Induced Bovine Platelet Aggregation
; Gustin, Pascal ; Herion, Francine et al
in Veterinary Journal (1998), 155(2), 201-203Detailed reference viewed: 64 (3 ULg)
The radial glial cell antigen recognized by the RC2 antibody is an intermediate-filament associated protein
; ; et al
Poster (1998)Detailed reference viewed: 2 (0 ULg)
Pleidooi voor en civilistische aanpak van overeenkomsten gesloten in het kader van overheidsopdrachten
Boularbah, Hakim ;
in Chroniques de Droit Public = Publiekrechtelijke Kronieken (1998)Detailed reference viewed: 6 (0 ULg)
Impact of different environmental managements on spatial distribution of ventilation in COPD horses
Vandenput, Sandrina ; Rollin, Frédéric ; Votion, Dominique et al
in Plügers Archives European Journal of Physiology (1998)Detailed reference viewed: 5 (1 ULg)
Pour des services d'accueil de qualité : quel accompagnement ?
; Pirard, Florence
in Accompagnement - a milestone toward quality. Differents ways of providing mentoring support in Europe (1998)Detailed reference viewed: 15 (6 ULg)
The modulation of movement as a behavioral adaptation to extreme environments in the newt Triturus alpestris cyreni
in Journal of Herpetology (1998), 32Detailed reference viewed: 133 (8 ULg)
Traitement ultime du diabete de type 2: insulinotherapie intensive ou chirurgie bariatrique?
Scheen, André ; Paquot, Nicolas ; et al
in Journées Annuelles de Diabetologie de l'Hôtel-Dieu (1998)Detailed reference viewed: 63 (2 ULg)
A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family.
Charlier, Carole ; ; et al
in Nature Genetics (1998), 18(1), 53-5
Epileptic disorders affect about 20-40 million people worldwide, and 40% of these are idiopathic generalized epilepsies (IGEs; ref. 1). Most of the IGEs that are inherited are complex, multigenic diseases ... [more ▼]
Epileptic disorders affect about 20-40 million people worldwide, and 40% of these are idiopathic generalized epilepsies (IGEs; ref. 1). Most of the IGEs that are inherited are complex, multigenic diseases. To address basic mechanisms for epilepsies, we have focused on one well-defined class of IGEs with an autosomal-dominant mode of inheritance: the benign familial neonatal convulsions (BFNC; refs 2,3). Genetic heterogeneity of BFNC has been observed. Two loci, EBN1 and EBN2, have been mapped by linkage analysis to chromosome 20q13 (refs 5,6) and chromosome 8q24 (refs 7,8), respectively. By positional cloning, we recently identified the gene for EBN1 as KCNQ2 (ref. 9). This gene, a voltage-gated potassium channel, based on homology, is a member of the KQT-like family. Here we describe an additional member, KCNQ3. We mapped this new gene to chromosome 8, between markers D8S256 and D8S284 on a radiation hybrid map. We screened KCNQ3 for mutations in the large BFNC family previously linked to chromosome 8q24 in the same marker interval. We found a missense mutation in the critical pore region in perfect co-segregation with the BFNC phenotype. The same conserved amino acid is also mutated in KVLQT1 (KCNQ1) in an LQT patient. KCNQ2, KCNQ3 and undiscovered genes of the same family of K+ channels are strong candidates for other IGEs. [less ▲]Detailed reference viewed: 8 (2 ULg)
Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans.
Louis, Edouard ; ; Piron, Anne et al
in Clinical & Experimental Immunology (1998), 113(3), 401-406
TNF-alpha is involved in infectious and immuno-inflammatory diseases. Different individuals may have different capacities for TNF-alpha production. This might determine a predisposition to develop some ... [more ▼]
TNF-alpha is involved in infectious and immuno-inflammatory diseases. Different individuals may have different capacities for TNF-alpha production. This might determine a predisposition to develop some complications or phenotypes of these diseases. The aims of our study were to assess the inter-individual variability of TNF-alpha production and to correlate this variability to a single base pair polymorphism located at position -308 in TNF gene. We studied 62 healthy individuals. TNF-alpha production after LPS stimulation was evaluated using a whole blood cell culture model. The TNF gene polymorphism was studied by an allele-specific polymerase chain reaction. Other cytokines produced in the culture, soluble CD14 concentrations and expression of CD14 on blood cells were also measured. Among the 62 individuals, 57 were successfully genotyped. There were 41 TNF1 homozygotes and 16 TNF1/TNF2 heterozygotes. TNF-alpha production after LPS stimulation of whole blood cell culture was higher among TNF2 carriers than among TNFI homozygotes (929pg/ml (480-1473pg/ml) versus 521 pg/ ml (178-1307 pg/ml); P<0.05). This difference was even more significant after correction of TNF-alpha production for CD14 expression on blood cells. In conclusion, the single base pair polymorphism at position -308 in the TNF gene may influence TNF-alpha production in healthy individuals. [less ▲]Detailed reference viewed: 63 (11 ULg)
Les thiazolidinediones : quel avenir dans le traitement du diabète de type 2 ?
SCHEEN, André ; PAQUOT, Nicolas ; LETIEXHE, Michel et al
in Médecine et Hygiène (1998), 56Detailed reference viewed: 14 (0 ULg)
Effects of regular or lispro insulin on glucose metabolism after an oral glucose load in patients with type 2 diabetes mellitus
PAQUOT, Nicolas ; ; et al
in Diabetes (1998), 47(suppl 1), 3Detailed reference viewed: 10 (0 ULg)
Quelques repères sur le développement des lieux d'accueil de la Petite enfance en Communauté germanophone de Belgique
Conference (1998)Detailed reference viewed: 10 (2 ULg)
Construction de tarifs de cubage d'arbres pour l’aulne glutineux (Alnus glutinosa (L.) Gaertn.).
; Rondeux, Jacques ; Claessens, Hugues
in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(3), 203-213Detailed reference viewed: 29 (7 ULg)