Synthesis and pharmacological evaluation of ATP-sensitive potassium channel openers related to cromakalim: introduction of arylsulfonylurea or benzothiadiazinedioxide moieties

Poster (1998, September)

2,3-Dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors

Poster (1998, September)

Transglutaminase-Mediated Oligomerization of Galectin-3 Modulates Human Melanoma Cell Interactions with Laminin

in Cell Adhesion and Communication (1998), 5(6), 425-35

Tumor cell adhesion and migration to laminin are important events during invasion and metastatic spread. Galectin-3, a multifunctional member of the galectin family, binds specifically the poly-N ... [more ▼]

Tumor cell adhesion and migration to laminin are important events during invasion and metastatic spread. Galectin-3, a multifunctional member of the galectin family, binds specifically the poly-N-acetyllactosamine residues of laminin and has been implicated in tumor invasion and metastasis. Galectin-3 is multimerized by transglutaminase, an enzyme that catalyzes cross-linking between glutamine and other aminoacid residues. In this study, we examined the consequences of transglutaminase-mediated galectin-3 oligomerization on the interactions between cancer cells and laminin. We first demonstrated that human galectin-3 is cross-linked by guinea pig liver transglutaminase, forms oligomers, and incorporates the marker 5-(biotinamido) pentylamine. Expression of transglutaminase activity in the A375 and A2058 human melanoma cell extracts was revealed by its ability to induce galectin-3 oligomerization and 5-(biotinamido) pentylamine incorporation. Transglutaminase-treated galectin-3 did not affect adhesion or migration of the melanoma cells to laminin but consistently induced a significant increase of the percentage of cell spreading compared to the control (23.5 +/- 2.3%, vs. 10.6 +/- 1.9% at 180 min, p < 0.05), or to untreated galectin-3 or transglutaminase alone. Our study is the first demonstration that human galectin-3 is oligomerized by transglutaminase with, as a consequence, a specific effect of melanoma cell spreading on laminin. This phenomenon could be of significance in the modulation of cancer cell interactions with laminin during tumor invasion and metastasis. [less ▲]

Preparative resolution of racemic pirlindole: chromatographic methods and determination of the absolute configuration

Poster (1998, September)

Système d'Information Multimédia de Gestion Environnementale des Communes

Report (1998)

The principal goal of the study is to equip the small ones and common averages, of the computer tools of which they miss as regards management of the environment, and in particular in the following fields ... [more ▼]

The principal goal of the study is to equip the small ones and common averages, of the computer tools of which they miss as regards management of the environment, and in particular in the following fields: - the quality of the built medium, public spaces and the landscapes; - the consumption of energy of heating in the public buildings and the management of public lighting; - draining, the cleansing, the management of the cycle of water; - the waste harvest and processing. [less ▲]

Stratégies vaccinales pour le médecin généraliste. I. A propos d'une recherche-action

in Revue Médicale de Liège (1998), 53(9), 541-52

The methodology of "Research-Action" requires that the general practitioner acts as the observant as well the actor. This methodology is a good way to identify the several problems and to find their ... [more ▼]

The methodology of "Research-Action" requires that the general practitioner acts as the observant as well the actor. This methodology is a good way to identify the several problems and to find their solution. In this option, the G.P. is the main person to plan, to manage and to follow the vaccination program for the "six and more years old children". [less ▲]

Mixed monolayers of gluten-emulsifiers at the air-water interface.

Poster (1998, September)

Exploration isocinétique de la relation tension longueur musculaire

in Archives of Physiology & Biochemistry (1998, September), 106(Suppl B), 128

La relation force vitesse étudiée en isocinétisme

in Archives of Physiology & Biochemistry (1998, September), 106(Suppl B), 70

Evidence for a dialogue between human endometrium and embryological signals in implantation and tolerance of the fetal allograft

Conference (1998, September)