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See detailThe burden of illness of hypopituitary adults with growth hormone deficiency.
Hakkaart-van Roijen, L.; Beckers, Albert ULg; Stevenaert, Achille ULg et al

in PharmacoEconomics (1998), 14(4), 395-403

Objective: The negative metabolic and psychosocial consequences of growth hormone deficiency (GHD) in adults are now well established. In the present study, an attempt was made to quantify the burden of ... [more ▼]

Objective: The negative metabolic and psychosocial consequences of growth hormone deficiency (GHD) in adults are now well established. In the present study, an attempt was made to quantify the burden of illness, in terms of lost productivity and increased medical consumption, associated with hypopituitarism and untreated GHD. Design and Setting: The study population consisted of 129 Belgian adults with untreated GHD associated with hypopituitarism after pituitary surgery. The Short-Form 36 Health Survey (SF-36) was used to assess health status, and the Health and Labour Questionnaire was used to measure production losses and labour performance. Data on medical consumption were also collected. Main Outcome Measures and Results: Hypopituitary patients reported a lower health status than that of the general population in all but two dimensions of the SF-36 (pain and physical functioning). Nearly 11% of the patients reported being incapacitated for paid employment due to health problems, compared with 4.8% of the general Belgian population. Patients in paid employment reported a mean of 19.8 days of sickness leave per year, which is twice that in the general population. The annual number of visits to general practitioners and specialists was also higher in the patients (9.6 and 6.5 visits, respectively, for the patients compared with corresponding figures of 2.1 and 1.5 for the general Belgian population). The average annual number of days spent in hospital was 3.5 for the patients compared with 2.3 in the general population. The annual healthcare costs and costs due to production losses calculated for hypopituitary patients who had received pituitary surgery amounted to 135 024 Belgian francs (BeF) or $US4340 (1995 values). This compares with the mean annual cost per person for the Belgian population as a whole of BeF68 569 or $US2204. Conclusions: Hypopituitary patients with untreated GHD therefore have a higher cost to society in terms of lost production and medical consumption than the average Belgian population. [less ▲]

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See detailLa troponine, nouveau marqueur de l'infarctus du myocarde
Chapelle, Jean-Paul ULg

in Revue Médicale de Liège (1998), 53(10), 619-24

The troponin (Tn) complex consists of three protein subunits referred to as TnT, TnI and TnC. Myocardium contains TnI and TnT isoforms which are not present in skeletal muscles and which can be separated ... [more ▼]

The troponin (Tn) complex consists of three protein subunits referred to as TnT, TnI and TnC. Myocardium contains TnI and TnT isoforms which are not present in skeletal muscles and which can be separated from the muscular isoforms by immunological techniques. Using commercially available immunoassays, clinical laboratories are able to determine cardiac TnT and TnI (cTnT and cTnI) as quickly and reliably as classical cardiac markers. After acute myocardial infarction, cTnT and cTnI concentrations start to increase in serum in a rather similar way than CK-MB, but return to normal after longer periods of time (approximately one week). Because of their excellent cardiac specificity, Tn subunits appear ideally suited for the differential diagnosis of myocardial and muscular damage, for example in non cardiac surgery patients, in patients with muscular trauma or with chronic muscular diseases, or after intensive physical exercise. cTnT and cTnI may also be used for detecting evidence of minor myocardial damage, and therefore may find new applications in the management of patients with unstable angina. [less ▲]

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See detailFoam-like evolution in polycrystalline systems following successive 'melt and growth' cycles
Vandewalle, Nicolas ULg; Delisse, B.; Ausloos, Marcel ULg et al

in Philosophical Magazine B-Physics of condensed matter statistical mechanics electronic optical and magnetic properties (1998), 78(4), 397-408

A stochastic model of multigrain growth which allows for successive melting-growth cycles is investigated on a square lattice. Two fundamental constraints are introduced: (i) the melted mass amplitude and ... [more ▼]

A stochastic model of multigrain growth which allows for successive melting-growth cycles is investigated on a square lattice. Two fundamental constraints are introduced: (i) the melted mass amplitude and (ii) the number of cycles guide the process. The evolution of the microstructure is found to be quite similar to foam systems, i.e. topological rearrangements are observed together with the increase of the-mean grain area. A drastic crossover between two types of growth regimes is found as a function of the amplitude of the melting-growth cycles. This allows one to envisage the existence of optimal conditions for polycrystal processing. [less ▲]

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See detailPichia anomala strain K against post-hervest diseases
Jijakli, Haissam ULg

Scientific conference (1998, October)

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See detailParticipation et intérêt politiques de lycéens français, belges et québécois au début des années quatre-vingt-dix : Une analyse plurielle fondée sur la dynamique de construction des univers de référence
Fournier, Bernard ULg

Doctoral thesis (1998)

Although certain recent theoretical developments insist more on the plurality of social and individual realities, the answers to empirical questions such as Are the young involved? or Are they interested ... [more ▼]

Although certain recent theoretical developments insist more on the plurality of social and individual realities, the answers to empirical questions such as Are the young involved? or Are they interested in politics? still too often fit in a univocal logic of comprehension where concepts used are thought to be homogeneous, as if they were “subsumptions”. This is why it is coherent to explain phenomena from a linear point of view which supposes a precise vision of the processes of construction of individual worlds of reference. Jean Piaget’s perspective of socialization reminds us that the individual is not a passive being in the dynamics of appropriation of the world, but that he assimilates the social context, accommodates it to what he already understands and, thus, transforms it. Consequently, this opens the way to a form of conceptual relativism, with a plural logic of comprehension where each reality, each concept cannot be defined without being replaced in the context of the singular worlds of reference. Thus, the theoretical consideration of the plural possibilities must also emerge from our interpretations. This research challenge is raised in this thesis by studying a series of profiles of dimensions, where each dimension can be replaced in a context which materializes a certain organization of realities. The complexity thus introduced into the analysis is synthesized by multivariate statistical methods (analysis of multiple correspondences and hierarchical ascending classification) which respect the initial organization of profiles. On the basis of data from an original inquiry among French, Belgian and Québécois high-school students, series of “clusters” of similar individuals are presented to describe, in a plural way, their participation and their political interests at the beginning of the nineties. [less ▲]

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See detailL'image du mois. Embolisation utérine d'une tumeur trophoblastique persistante
Foidart, Jean-Michel ULg; Henroteaux, D.; Schaaps, Jean-Pierre ULg

in Revue Médicale de Liège (1998), 53(10), 585

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See detailPharma clinics. Comment je traite ... ou préviens une douleur par "patches"
Pierard, Gérald ULg

in Revue Médicale de Liège (1998), 53(10), 586-7

There exists two distinct types of patches aiming at increasing the pain threshold either systematically or locally. The first type of analgesic patch is a real transdermal delivery system releasing ... [more ▼]

There exists two distinct types of patches aiming at increasing the pain threshold either systematically or locally. The first type of analgesic patch is a real transdermal delivery system releasing fentanyl. Such potent opioid drug exerts a systemic effect. The other type of patch associates lidocain and prilocain to induce a local anesthesia of the skin without inducing a systemic effect. [less ▲]

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See detailRestriction of mobility in model liquid crystalline ionomers
Gohy, Jean-François; Jérôme, Robert ULg; Van den Bossche, Guy ULg et al

in Macromolecular Chemistry and Physics (1998), 199(10), 2205-2210

Model liquid crystalline ionomers have been analyzed by SAXS both in bulk and in toluene solution. These compounds are referred to as liquid crystalline halatosemitelechelic polystyrenes (LC HSTP's) and ... [more ▼]

Model liquid crystalline ionomers have been analyzed by SAXS both in bulk and in toluene solution. These compounds are referred to as liquid crystalline halatosemitelechelic polystyrenes (LC HSTP's) and consist of low molecular weight polystyrene chains end-capped at one end by a sulfonate group associated to a mesogenic counterion. The results are in agreement with a microphase separation between the polymer chain and the mesogenic counterion. The main characteristic feature of the SAXS profile for the bulk material is the so-called ionic peak, whose position obeys a general law which is in favor of a rod-like organization of the multiplets and which shows that the polymer chains are stretched in the very close vicinity of the mesogenic core, in agreement with the Eisenberg, Hird and Moore model for ionomers. The thickness of this region of restricted mobility has been estimated to 1 nm, which is the order of magnitude of the persistence length of polystyrene. This very local restriction in mobility persists in toluene solution, in contrast to what is observed for the ω-Li-sulfonato-polystyrene precursors. The results also agree with an isotropic distribution of the multiplets in toluene. [less ▲]

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See detailMolecular Biology of Antimicrobial resistance
Melin, Pierrette ULg

Conference (1998, October)

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See detailThe use of thermal regulations to classify architectural projects from their energy performance
Hauglustaine, Jean-Marie ULg; Duforestel, Thierry

Report (1998)

The choice to himself interest with lawful methods results from the will to widen the evaluation of the project performances with a set of criteria (sound insulation, fire resistance, illumination, etc ... [more ▼]

The choice to himself interest with lawful methods results from the will to widen the evaluation of the project performances with a set of criteria (sound insulation, fire resistance, illumination, etc.), all criteria which are not necessarily objects of a collection of evaluation tools, like in energy matters. Such an approach justifies of hold with some simplified methods for the evaluation of the performance energy and, when they exist, for the evaluation of the other qualities. [less ▲]

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See detailConception des ouvrages hydrauliques
Rigo, Philippe ULg

in Ingénieur et Industrie, APPS éditions, n°5 (1998)

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See detailStadsverkeer: problemen en olpossingen
Marchal, Jean ULg

in Publication du CAWET (Comité van de Academie voor Wetenschappen en Techniek) (1998)

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See detailLes productions animales à l'aube du troisième millénaire: enjeux et défis.
Thewis, André ULg

Learning material (1998)

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See detail18fdg-Pet for the Assessment of Primary Head and Neck Tumors: Clinical, Computed Tomography, and Histopathological Correlation in 38 Patients
Paulus, Patrick; Sambon, A.; Vivegnis, Danielle et al

in Laryngoscope (1998), 108(10), 1578-83

OBJECTIVES: To evaluate the clinical usefulness of FDG-PET (fluoro-2-deoxy-glucose-positron emission tomography) in the detection of lymph node involvement and recurrences in patients with head and neck ... [more ▼]

OBJECTIVES: To evaluate the clinical usefulness of FDG-PET (fluoro-2-deoxy-glucose-positron emission tomography) in the detection of lymph node involvement and recurrences in patients with head and neck cancer. STUDY DESIGN: Retrospective review of 38 patients with biopsy-proven head and neck cancers who underwent clinical, computed tomography (CT), and FDG-PET examinations. Twenty-five patients were studied prior to therapy and 13 patients were evaluated for disease recurrence. METHODS: All patients were operated and clinical data, CT, and FDG-PET results were correlated with histopathological findings. RESULTS: All primary tumors in 25 patients were detected, with the exception of one small superficial localization of the epiglottis. Histopathological examination showed lymph node involvement in 10 patients; PET detected lymph node involvement in five. FDG-PET found one case of nodal disease not identified by clinical and CT examination. With so few cases, this could be anecdotal. Five false-negative results (microscopic lymph node involvement) and two false positives were noted. Twelve of 13 patients with recurrent disease were correctly identified with FDG-PET. FDG-PET was the only imaging technique to identify local recurrence in two patients and lymph node involvement in two others. One false-positive result occurred in a patient with a foreign body granuloma. CONCLUSIONS: FDG-PET is a useful diagnostic modality for the detection of recurrent tumors and, in selected cases, precise lymph node involvement. The best way to further investigate the utility of clinical FDG-PET is in the follow-up of treated patients. [less ▲]

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See detailExpression and Modulation of Homeobox Genes from Cluster B in Endothelial Cells
Belotti, D.; Clausse, Nathalie; Flagiello, D. et al

in Laboratory Investigation : Journal of Technical Methods & Pathology (1998), 78(10), 1291-9

Angiogenesis is a complex phenomenon likely to be under the strict control of a group of transcription factor(s). Homeobox (HOX)-containing proteins have been identified as regulators controlling the ... [more ▼]

Angiogenesis is a complex phenomenon likely to be under the strict control of a group of transcription factor(s). Homeobox (HOX)-containing proteins have been identified as regulators controlling the coordinated expression of genes involved in organ development and tissue differentiation. In this study, we have demonstrated that human umbilical vein endothelial cells (HUVEC) express 8 of the 10 HOX genes contained in cluster B. Treatment of HUVEC with tissue plasminogen activator (TPA), an agent known to induce morphologic changes in endothelial cells, or vascular endothelium growth factor (VEGF), a proliferative and angiogenesis inducer, results in a specific time-dependent modulation of the eight HOX genes identified. Interestingly, neither basic fibroblast growth factor, an endothelial proliferative agent, nor TNP-470, a fumagillin derivative with potent antiendothelial cell proliferation properties, affected expression of these HOX genes. Specific modulation of HOX genes by differentiating agents but not by proliferative or antiproliferative molecules suggests that they could be involved in the control of the genetic program that coordinates the construction of new blood vessels. [less ▲]

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See detailLe matérialisme transcendantal
Seba, Jean-Renaud ULg

in Cahiers marxistes (1998)

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