References of "1998"
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See detailEfficiency and productivity of the health sector in the OECD countries (1970-1994)
Fecher-Bourgeois, Fabienne ULg

Scientific conference (1998, November)

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See detailPowerful alternative asymmetric Catalytic dihydroxylation of olefins
Colaux, Catherine ULg; Krief, Alain; Dumont, Willy

Poster (1998, November)

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See detailtournois internationaux, SUPPORTERS, HOOLIGANS ET MESURES DE PREVENTION DANS LES STADES EN EUROPE
Comeron, Manuel ULg; Kellens, Georges ULg; Demeulenaer, Stijn

Report (1998)

Analyse de la nature, de la dynamique et du mode de fonctionnement des supporters européens, dont les noyaux durs, attachés à des équipes nationales (avec une attention particulière aux pays de l’Est ... [more ▼]

Analyse de la nature, de la dynamique et du mode de fonctionnement des supporters européens, dont les noyaux durs, attachés à des équipes nationales (avec une attention particulière aux pays de l’Est). Constitution d’une « typologie» sur les caractéristiques, comportements et habitudes des supporters internationaux. Analyse et évaluation de l’impact des stratégies de contrôle des supporters et des mesures de sécurité policières (maintien de l’ordre public), préventives (stewarding, fanprojects, animations) et organisationnelles (infrastructures, billetterie, vente d’alcool) mises en place dans les stades de football européens, notamment à l’occasion des tournois internationaux (Championnats d’Europe des Nations et Coupes du Monde). Propositions afin de transposer et adapter des stratégies d’intervention expérimentées avec des effets positifs à l’étranger pour l’organisation sécuritaire de l’Euro 2.000 [less ▲]

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See detailMémoire de travail et maladie d’Alzheimer
Collette, Fabienne ULg

Scientific conference (1998, November)

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See detailEvaluation of a Diphenylphosphorylazide-Crosslinked Collagen Membrane for Guided Bone Regeneration in Mandibular Defects in Rats
Zahedi, Sharam ULg; Legrand, Roman ULg; Brunel, G. et al

in Journal of Periodontology (1998), 69(11), 1238-46

In the present study, the potential of a diphenylphosphorylazide-crosslinked type I bovine collagen membrane was evaluated in the healing of mandibular bone defects applying the biological concept of ... [more ▼]

In the present study, the potential of a diphenylphosphorylazide-crosslinked type I bovine collagen membrane was evaluated in the healing of mandibular bone defects applying the biological concept of guided bone regeneration. The experiment was carried out on 25 Wistar rats. After exposing the mandibular ramus bilaterally, 5 mm diameter full-thickness circular bone defects were surgically created. While the defect on one side was covered by the membrane (experimental), the defect on the other side was left uncovered (control) before closure of the overlying soft tissues. The rats were sacrificed in groups of 5 after 7, 15, 30, 90, and 180 days of healing. Although at early stages of healing similar amounts of bone formation were observed in the experimental and control defects, after 1 month of healing, most of the experimental defects were completely closed with new bone, while in the control defects, only limited amounts of new bone were observed at the rims and in the lingual aspect of the lesions. In the 90- and 180-day animals, all experimental defects were completely closed, while in the control defects, no statistically significant increase in bone regeneration was observed. The increase in percentage of bone regeneration in the experimental defects was statistically significant between the 15-day specimens as compared with the 7-day specimens (P < 0.01) and likewise between 30-day and 15-day specimens (P < 0.001). It can be concluded that a DPPA-crosslinked collagen membrane yields biocompatibility, ad hoc mechanical hindrance, and handling characteristics suitable for guided bone regeneration applications in this experimental model. [less ▲]

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See detailOptimum Complexity of Marine Ecosystem Models
Dauby, Patrick ULg; Nihoul, Jacques

Conference (1998, November)

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See detailEffet tequila, effet domino, effet vodka : à qui la faute ?
Santander, Sébastian ULg

Article for general public (1998)

L'article se penche sur les différentes crises qui ont traversé l'Asie, la Russie et l'Amérique latine à la fin des années 1990. Il cherche à déterminer les raisons de ces crises.

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See detailWill Belgium disappear ? : a European democracy between crisis and transition
Martiniello, Marco ULg

Scientific conference (1998, October 23)

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See detailFgf-3 and Fgf-4 Elicit Distinct Oncogenic Properties in Mouse Mammary Myoepithelial Cells
Hajitou, Amin; Baramova, Eugénia; Bajou, Khalid ULg et al

in Oncogene (1998), 17(16), 2059-71

Fibroblast Growth Factors 3 (FGF-3) and 4 (FGF-4) were compared for the effects they each exert on EF43 mouse cells. This non-transformed mammary cell line appears to be myoepithelial mainly because it ... [more ▼]

Fibroblast Growth Factors 3 (FGF-3) and 4 (FGF-4) were compared for the effects they each exert on EF43 mouse cells. This non-transformed mammary cell line appears to be myoepithelial mainly because it expresses alpha-smooth muscle actin. The EF43 cells were infected with similar vectors that carry either the short fgf-3 sequence (the product of which goes into the secretory pathway), fgf-4 or the selection gene only as control. In syngeneic animals, EF43.fgf-3 cells were tumorigenic only when orthotopically implanted whereas EF43.fgf-4 cells invariably gave rise to aggressive tumors. However, both tumor types were metastatic as evidenced by the blue micrometastases observed when the implanted cells expressed lacZ. In vitro, the FGF-3 producing cells were strongly invasive in matrigel coated chambers whereas the EF43.fgf-4 cells only were invasive in type I-collagen gels. Interestingly, FGF-3 production greatly stimulated the synthesis of pro-MMP-9 (Matrix Metalloprotease-9) and, to a lesser extent, that of pro-MMP-2. FGF-3 also up-regulated the production of plasminogen activators. In contrast, FGF-4 had no effect on these secretions and the medium conditioned by the EF43.fgf-4 cells displayed the largest plasminogen activator-inhibitor activity. These results show that FGF-3 and FGF-4 have distinct mechanisms of action on myoepithelial cells. [less ▲]

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See detailTransmission and confocal fluorescence microscopy and time-resolved fluorescence spectroscopy combined with a laser trap: investigation of optically trapped block copolymer micelles
Gensch, Thomas; Hofkens, Johan; van Stam, Jan et al

in Journal of Physical Chemistry B (1998), 102(43), 8440-8451

Optical trapping was combined with transmission microscopy (TM), confocal and nonconfocal fluorescence scanning microscopy (CFSM and FSM, respectively), and confocal and nonconfocal time-resolved ... [more ▼]

Optical trapping was combined with transmission microscopy (TM), confocal and nonconfocal fluorescence scanning microscopy (CFSM and FSM, respectively), and confocal and nonconfocal time-resolved fluorescence spectroscopy (CTRFS and TRFS, respectively) to study latex particles and block copolymer micelles. Dye-labeled latex particles of various size, in polymer composite films as well as optically trapped in solution, were studied with CFSM to characterize the limits of the setup. CFSM revealed that the resolution in the x- and y-directions was near the theoretical limit, i.e., 200−250 nm. CTRFS on the labeled latex particles revealed that the decay time of the label was not influenced by the polymer matrix nor the optical trap. Poly(tert-butylstyrene-block-sodium methacrylate) micelles (diameter approximately 30−40 nm) in deuterated aqueous solutions could be optically trapped, this region of high copolymer micelle concentration being referred to as a trapped cluster. In the transmission images, trapped clusters of 1.5−2 μm diameter were detected. Fluorescence images were obtained using perylene as a fluorophore that is specifically dissolved within the block copolymer micelles. The size of the trapped cluster, estimated from TM and FSM images, increases with increasing irradiation time and power, respectively. In the TM images, the trapped cluster appears as a dark spot (low transmission) with a bright (high transmission) corona-like ring around it. The appearance of the corona is explained as a light deflection phenomenon; i.e., the trapped cluster acts as lens due to a lateral refractive index gradient. When the corona is taken into account when the diameter of the trapped clusters is calculated, a very good agreement is found between TM and FSM. Long irradiation times lead to the formation of large trapped clusters, which are stable for about 10 s, with diameters of several hundred nanometers, while, for short irradiation times, the trapped cluster is smaller and disappears within a time less than 1 s. With CFSM it could be shown that the trapped particle has a spot size of approximately 1.7 μm in the region of the IR laser focus, while the diameter extends up to 5 μm without using the confocal imaging capability. The reason for this is that the conditions for optical trapping are fulfilled not only in but also above and below the focal region. Due to the high numerical aperture, a dumbbell-like shape of the trapped cluster results. [less ▲]

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See detailprimary HFOV in near term and term neonates with respiratory failure
Battisti, Oreste ULg; Biebuyck, N.; Kalenga, M. et al

Conference (1998, October 21)

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See detailTnf-Alpha and Ifn-Gamma Down-Regulate the Expression of the Metastasis-Associated Bi-Functional 37lrp/P40 Gene and Protein in Transformed Keratinocytes
Clausse, Nathalie; van den Brûle, Frédéric; Delvenne, Philippe ULg et al

in Biochemical and Biophysical Research Communications (1998), 251(2), 564-9

The 37 LRP/p40 molecule is a bi-functional protein in which expression is increased in a large variety of cancers in association with their metastatic phenotype. Here we present the first data concerning ... [more ▼]

The 37 LRP/p40 molecule is a bi-functional protein in which expression is increased in a large variety of cancers in association with their metastatic phenotype. Here we present the first data concerning the 37 LRP/p40 gene promoter activity and show that it is very active in a cervix carcinoma cell line. Interestingly, despite hallmarks of a housekeeping gene, we show that the 37 LRP/p40 gene promoter can be down-regulated by two potentially anticancerous cytokines, TNF-alpha and IFN-gamma. In addition, the dual fate of the protein, i.e., being intracellularly involved in the cell translation machinery and incorporated into a 67-kDa cell surface protein functioning as a laminin receptor (67LR), is differentially affected by the treatment. Our data suggest multiple regulation levels in the control of the 67LR/37LRP/p40 molecule expression and uncover new clues for the understanding of both the control of expression of this metastasis-associated molecule and the IFN-gamma and TNF-alpha anticancerous action. [less ▲]

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See detailInvestigation of methyl methacrylate and vinyl acetate polymerization promoted by Al(iBu)3/2,2'-bipyridine and Al(iBu)3/2,2'-bipyridine/TEMPO complexes
Granel, Claude; Jérôme, Robert ULg; Teyssié, Philippe et al

in Macromolecules (1998), 31(21), 7133-7141

Results of methyl methacrylate (MMA) and vinyl acetate (VOAc) polymerization using the Al(iBu)3/2,2‘-bipyridine/TEMPO initiating system at room temperature failed to confirm the “living” radical mechanism ... [more ▼]

Results of methyl methacrylate (MMA) and vinyl acetate (VOAc) polymerization using the Al(iBu)3/2,2‘-bipyridine/TEMPO initiating system at room temperature failed to confirm the “living” radical mechanism reported earlier. Several species apparently propagate without control in a normal free radical process and only above a critical initiator concentration. No evidence was found for the penta- and hexacoordinated aluminum species previously suggested, but high conversion to an alkoxyamine was observed. Additionally, mixing Al(iBu)3 and BIPY promotes a variety of reactions involving alkyl and hydride transfers to the aromatic rings forming reduced BIPY products, along with a persistent organoaluminum radical. All these results illustrate that the process is considerably more complicated than postulated before. Conversely, at −78 °C, a single active species excluding the participation of TEMPO has been put in evidence, displaying some “living” characteristics. Several experiments support its anionic nature, as previously suggested by Ikeda. [less ▲]

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See detailCarbon Dioxide Emission from European Estuaries
Frankignoulle, Michel; Abril, Gwenaël; Borges, Alberto ULg et al

in Science (1998), 282(5388), 434-6

The partial pressure of carbon dioxide (pCO2) in surface waters and related atmospheric exchanges were measured in nine European estuaries. Averaged fluxes over the entire estuaries are usually in the ... [more ▼]

The partial pressure of carbon dioxide (pCO2) in surface waters and related atmospheric exchanges were measured in nine European estuaries. Averaged fluxes over the entire estuaries are usually in the range of 0.1 to 0.5 mole of CO2 per square meter per day. For wide estuaries, net daily fluxes to the atmosphere amount to several hundred tons of carbon (up to 790 tons of carbon per day in the Scheldt estuary). European estuaries emit between 30 and 60 million tons of carbon per year to the atmosphere, representing 5 to 10% of present anthropogenic CO2 emissions for Western Europe. [less ▲]

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See detailLes Poésies de Stéphane Mallarmé
Durand, Pascal ULg

Conference given outside the academic context (1998)

Entretien avec Benoît Denis à propos de Pascal Durand, Poésies de Mallarmé, Paris, Gallimard, Foliothèque, 1998

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See detailInterlocking Biological and Political Uncertainties in Public Decision Making : A Case Study at Mellery (Belgium)
Fallon, Catherine ULg; Laurent, Christian

Conference (1998, October 13)

A central question in health hazard associated with environmental pollution is the evaluation of level of exposure to a mixture of carcinogens and the estimation of the global health impact on the ... [more ▼]

A central question in health hazard associated with environmental pollution is the evaluation of level of exposure to a mixture of carcinogens and the estimation of the global health impact on the residents. The point is important to found a public health decision for site intervention or residents relocalisation. Belgium had to face such a problem at Mellery, a village which became internationally famous some years ago, when local residents denonced a local pollution originating from an industrial waste depository facility situated only 500 m from the centre of their village, in a former sand quarry. A central piece of the actions of the authorities was the original campaign organised to measure directly the level of exposure to carcinogens of a large group of voluntary local residents, children included, by measuring biomarkers of exposure in blood lymphocytes : for its high sensitivity, the frequency of sister chromatid exchanges (SCES) had been chosen. This biomonitoring method, quite commonly used to monitor occupational environment, had never before been applied to evaluate the potential health impact of the environment on a general population. Such data, although sophisticate and integrative, are only indicators of exposure and cannot be used, so far, as individual quantitative predictors of the possible evolution of the health of the individual persons. First designed as an epidemiological study, the campaign at Mellery revealed so high exposure levels that the experts did not keep with the original experimental line and decided to release individual information to the concerned persons, without much preparation nor risk communication policy. Several groups (experts, local doctors, local and regional authorities, public agencies and residents associations) were active integrating the information in their respective discourses, giving them specific interpretative and competing meanings. Any scenario for intervention had to be embedded in some meaningful and legitimating discourse : a quite difficult task for the authorities. The evolution of the expertise system used for public decision-making were marked by several such uncertainties (geological, biological, medical) but also by the difficult integration of health related aspects within environment interventions in the regulatory structures in Belgium : health responsibilities are scattered between federal and "communautaire" bodies, while most of the environmental actions are funded at the regional level. In this first heavy case, the young regional institutions reacted in a disorganized manner: they choose to not put at risk their frail power equilibrium and to not reconsider the attribution of the responsibilities. The authors propose to analyse how peculiar interlocking of the biological and political uncertainties were at the core of the general failure in public risk management around this landfill site: Mellery, after 10 years and a huge budget for site treatment, is still a nightmare for environmental authorities in Southern Belgium. [less ▲]

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