Gezonheidszorg : actuele standpunten. Diagnostiek van osteoporose; Reginster, Jean-Yves ; et alin Tijdschrift voor Geneeskunde (1997), 53(10), 639-645 Detailed reference viewed: 11 (1 ULg) Thyroid hormone inhibits the human prolactin gene promoter by interfering with activating protein-1 and estrogen stimulations; ; Van de Weerdt, Cécile et alin Molecular Endocrinology (Baltimore, Md.) (1997), 11(7), 986-96 Transcription of the human PRL (hPRL) gene in the pituitary is subject to tissue-specific and multihormonal regulation involving two main regulatory regions, a proximal promoter and a distal enhancer. In ... [more ▼] Transcription of the human PRL (hPRL) gene in the pituitary is subject to tissue-specific and multihormonal regulation involving two main regulatory regions, a proximal promoter and a distal enhancer. In this report we show that thyroid hormone inhibits the expression of the hPRL gene in rat pituitary cells. Transient expression experiments show that thyroid hormone regulation involves a strong inhibitory element, located in the proximal (-164/-35) promoter, which is modulated by a more distal stimulatory response control region. Gel retardation experiments reveal that the thyroid hormone receptor does not bind to the proximal negative element. We show the existence of an activating protein-1 (AP-1) response element located at positions -61 to -54 of the proximal promoter, conferring AP-1 stimulation to the hPRL promoter. This AP-1 induction is abolished when hormone-bound thyroid hormone receptor is present, indicating that there is an interference between the thyroid hormone receptor and AP-1 regulatory pathways. Furthermore, using the complete hPRL upstream region, we show that estrogen induction is abolished by simultaneous thyroid hormone treatment. 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The Contact & the Culmination: Essays in Honour of Hena Maes-Jelinek (1997) Detailed reference viewed: 384 (10 ULg) Palynological evaluation of the Famennian Protosalvinia (Foerstia) Zone in the Amazon basin, Northern Brazil : a preliminary study.; ; et al in Review of Palaeobotany and Palynology (1997), 96 Detailed reference viewed: 4 (0 ULg) Quality of life as outcome in the treatment of osteoporosis : The development of a questionnaire for quality of life by the European Foundation for Osteoporosis; ; et al in Osteoporosis International (1997), 7 Detailed reference viewed: 9 (4 ULg) Osteoporosis : The interest of a prospective visionGillet, Pierre ; Gosset, Christiane ; Reginster, Jean-Yves ![]() in Calcified Tissue International (1997), 61 Detailed reference viewed: 16 (9 ULg) Du Rectorat à la PrésidenceDurand, Pascal ![]() Article for general public (1997) Interview de M. Emil Constantinescu, président de la République de Roumanie, à l'occasion de la remise de ses insignes de docteur honoris causa de l'ULg en 1997 Detailed reference viewed: 7 (1 ULg) Lecture critique d’un essai thérapeutiqueReginster, Jean-Yves ![]() in Revue du Rhumatisme (1997), 64(3), 84-86 Detailed reference viewed: 3 (1 ULg) Direct social costs of Osteoporotice hip fractures in BelgiumGillet, Pierre ; Gosset, Christiane ; Reginster, Jean-Yves ![]() in Calcified Tissue International (1997), 61 Detailed reference viewed: 30 (8 ULg) |
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