References of "1995"
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See detailModulation of B lymphocyte proliferation inside the germinal center.
Bosseloir, A. L.; Defrance, T.; Bouzahzah, F. et al

in Advances in Experimental Medicine and Biology (1995), 378

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See detailAdhesion and costimulatory molecules on human FDC in vitro.
Tsunoda, R.; Heinen, Ernst ULg; Imai, Y. et al

in Advances in Experimental Medicine and Biology (1995), 378

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See detailThe use of Sandimmun (cyclosporin A) in severe refractory rheumatoid arthritis: the Belgian experience
Malaise, Michel ULg; De Keyser, P.; De Backer, M. et al

in Clinical Rheumatology (1995), 14

OBJECTIVE: To investigate practicability, efficacy and tolerability of low starting doses of Sandimmun (cyclosporin A) (2.5 mg/kg daily) in patients with severe refractory rheumatoid arthritis in the ... [more ▼]

OBJECTIVE: To investigate practicability, efficacy and tolerability of low starting doses of Sandimmun (cyclosporin A) (2.5 mg/kg daily) in patients with severe refractory rheumatoid arthritis in the short (6 months) and middle (12 months) term. METHODS: Fifty-nine patients, presenting with active and severe rheumatoid arthritis unresponding to conventional DMRADs were allowed to start Sandimmun at the dose of 2.5 mg/kg daily. This dose was progressively increased by steps of 25 mg daily up to a maximum of 5 mg/kg daily according to the renal function and blood pressure. RESULTS: A mean maintenance dose of 3.9 mg/kg daily was reached after 5 months and maintained throughout the study. Twenty-one patients (36%) completed the one year study. The reasons for discontinuation were: inefficacy (13), adverse events (17), both inefficacy and adverse events (5) and non-compliance (3). For those patients who completed the trial, clinical relevant improvements were observed within 3 months of treatment and were maintained until the end of the study for the Lee functional and the Ritchie articular index, as well as for the number of tender and swollen joints. No changes for the grip strength, the biological and immunological parameters were observed. Mean serum creatinine values rose from 0.81 mg/dl at start to 1.1 mg/dl after 5 months of therapy and remained at that level throughout the study. In patients who discontinued, the serum creatinine level nearly normalized after one month of Sandimmun withdrawal. One hundred and sixty-two side effects were reported of which most were minor and known to occur with Sandimmun. Twenty-two cases (37% of patients) dropped out for adverse events before 1 year treatment. The criteria to withdraw the patients from the study differed greatly from centre to centre. CONCLUSIONS: Managing RA patients presenting with very long and severe disease remains difficult. Therefore low dose Sandimmun (2.5-5 mg/kg daily) appears to be a valuable therapeutic opportunity in RA patients refractory to various other conventional drugs, including methotrexate. [less ▲]

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See detailL'axe sol-plante-animal dans les tétanies d'herbe
Dufrasne, Isabelle ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1995), 139

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See detailSoya oil in diet for growing-fattening bulls: I. Effects on animal performances and carcass composition
Clinquart, Antoine ULg; Van Eenaeme, Christian ULg; Dufrasne, Isabelle ULg et al

in Journal of Animal Physiology & Animal Nutrition (1995), 74

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See detailChiral symmetry restoration in SU(2) and SU(3) Effective Lagrangians of QCD
Jaminon, Martine ULg; Van den Bossche, Bruno

Conference (1995)

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See detailAn early origin of plastids within the cyanobacterial divergence is suggested by evolutionary trees based on complete 16S rRNA sequences
Nelissen, Bart; Van De Peer, Yves; Wilmotte, Annick ULg et al

in Molecular Biology and Evolution (1995), 12

It is generally accepted that the plastids arose from a cyanobacterial ancestor, but the exact phylogenetic relationships between cyanobacteria and plastids are still controversial. Most studies based on ... [more ▼]

It is generally accepted that the plastids arose from a cyanobacterial ancestor, but the exact phylogenetic relationships between cyanobacteria and plastids are still controversial. Most studies based on partial 16S rRNA sequences suggested a relatively late origin of plastids within the cyanobacterial divergence. In order to clarify the exact relationship and divergence order of cyanobacteria and plastids, we studied their phylogeny on the basis of nearly complete 16S rRNA gene sequences. The data set comprised 15 strains of cyanobacteria from different morphological groups, 1 prochlorophyte, and plastids belonging to 8 species of plants and 12 species of diverse algae. This set included three cyanobacterial sequences determined in this study. This is the most comprehensive set of complete cyanobacterial and plastidial 16S rRNA sequences used so far. Phylogenetic trees were constructed using neighbor joining and maximum parsimony, and the reliability of the tree topologies was tested by different methods. Our results suggest an early origin of plastids within the cyanobacterial divergence, preceded only by the divergence of two cyanobacterial genera, Gloeobacter and Pseudanabaena. [less ▲]

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See detailStructure and characterization of isopyoverdin from Pseudomonas putida BTP1 and its relation to the biogenetic pathway leading to pyoverdins.
Jacques, Philippe ULg; Ongena, MARC ULg; Gwose, I. et al

in Zeitschrift für Naturforschung. C, Journal of Biosciences (1995), 50(9-10), 622-9

Pyoverdin type siderophores produced by six fluorescent Pseudomonas strains isolated from different rhizospheres were purified and characterized. The purified ferri-pyoverdins were tested for their ... [more ▼]

Pyoverdin type siderophores produced by six fluorescent Pseudomonas strains isolated from different rhizospheres were purified and characterized. The purified ferri-pyoverdins were tested for their ability to promote the growth of other strains grown under iron deficiency conditions. Only the one obtained from Pseudomonas putida BTP1 did not act as a growth promoter. The structure of the BTP1 siderophore was elucidated by spectroscopic methods and degradation studies. It turned out that it contains a chromophore which differs from the one typical for pyoverdins insofar as it carries the carboxyl group in 3- rather than in 1-position ((3S)-5-amino-1,2-dihydro-8,9-dihydroxy-3H-pyrimido[1,2a]quinoline-3- carboxylic acid). The amino group of the chromophore is substituted with the 5-carboxyl group of L-glutamic acid and its carboxyl group with the N-terminus of the peptide L-Asp-L-Ala-L-Asp-D-N5-Ac-N5-OH-Orn-L-Ser-L-c-N5-OH-Orn. This isopyoverdin fits into the biogenetic scheme which postulates ferribactins as the precursors of pyoverdins. [less ▲]

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See detailFlux de nitrate dans une zone à nappes superficielles en Wallonie (Belgique)
Demarets, X.; Marcoen, Jean Marie ULg; Agneessens, R. et al

in Cahiers Agricultures (1995), 4

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See detailLow-dose methotrexate: an effective corticosteroid-sparing agent in the musculoskeletal manifestations of sarcoidosis
Kaye, O.; Palazzo, E.; Grossin, M. et al

in British Journal of Rheumatology (1995), 34(7), 642-644

Extrapulmonary sarcoidosis, and particularly the presence of musculoskeletal complications of the disease, may require chronic corticosteroid therapy. In five patients with biopsy-proven sarcoidosis and ... [more ▼]

Extrapulmonary sarcoidosis, and particularly the presence of musculoskeletal complications of the disease, may require chronic corticosteroid therapy. In five patients with biopsy-proven sarcoidosis and presenting recalcitrant forms of the disease, we introduced low-dose oral methotrexate (MTX) [10 mg/week (7.5-15)] for 30 months (16-34) to control the clinical and biological symptoms as well as to try to reduce the intolerated steroid posology. Beneficial effects were observed within 8-12 weeks in all patients, which allowed a reduction of 59% (35-75) of the corticosteroid posology, and maintained with a follow-up of 3 yr in 4/5 patients. No significant toxicity was observed. MTX appears to be an efficient, safe and corticosteroid-sparing therapeutic agent for the treatment of recalcitrant musculoskeletal manifestations of sarcoidosis. [less ▲]

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See detailEn Belgique, diverses modalités de pâturage pour des taurillons avant finition à l'auge
Dufrasne, Isabelle ULg; Gielen, Marc ULg; Limbourg, Pierre et al

in Fourrages (1995), 141

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See detailUtilisation des matières grasses chez les bovins à l'engraissement
Clinquart, Antoine ULg; Micol, Didier; Brundseaux, Christophe et al

in Productions Animales (1995), 8

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See detailCholestase associée à l'administration de ticlopidine
Diaz Fuenzalida, A.; VALDES SOCIN, Hernan Gonzalo ULg

Poster (1995)

Ticlopidine is a antitrombotic agent. Cholestasis is an unfrequent adverse effect of ticlopidine. Althought transient liver transaminases elevations have been decribed in nearly 5% of cases, only 18 cases ... [more ▼]

Ticlopidine is a antitrombotic agent. Cholestasis is an unfrequent adverse effect of ticlopidine. Althought transient liver transaminases elevations have been decribed in nearly 5% of cases, only 18 cases of ticlopidine associated cholestasis have been published. No such a case has been described untill now in Latinoamerica. We describe the case of a 56 years old male with ticlopidine associated cholestasis. Liver biopsy showed acinar cholestasis and portal inflammatory infiltrate suggesting cholestasis due to hypersensitivity. The drug was discontinuated and not readministered. There was subsequently a progressive normalization of liver parameters. Althought rare, clinicians should be aware of this unfrequent adverse effect of ticlopidine. [less ▲]

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See detailNew data on the Sambre-et-Meuse Band
Steemans, Philippe ULg

Conference (1995)

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