Le projet FORCE - Return on Investment

Scientific conference (1995)

La gestion en temps réel des opérations relatives à l’exploitation du trafic fluvial

in Bulletin de l'Association Technique Maritime et Aéronautique (1995)

Absence probable de la translocation Robertsonienne 1/29 en race bovine Blanc Bleu Belge

in Genetics, Selection, Evolution [=GSE] (1995), 27(4), 377-380

The 1/29 translocation, a structural chromosomal abnormality, is often associated with infertility. For this reason, we wished to know its frequency in the Belgian Blue breed. In this study, none of the ... [more ▼]

The 1/29 translocation, a structural chromosomal abnormality, is often associated with infertility. For this reason, we wished to know its frequency in the Belgian Blue breed. In this study, none of the 138 Belgian Blue bulls karyotyped carried the 1/29 translocation. We calculated that the 1/29 translocation frequency in the Belgian Blue breed must be lower than 0.69% at the 5% level. This result can be explained by the origins of the breed. The Belgian Blue breed is descended from focal dairy breeds and from the Shorthorn breed, which can all be considered to be free of the 1/29 translocation. [less ▲]

Analyse critique de l'utilisation d'un appareil isocinétique

in Journal de Traumatologie du Sport (1995), 12

Structure, chromosomal location, and expression pattern of three mouse genes homologous to the human MAGE genes.

in Genomics (1995), 28(1), 74-83

The human MAGE1 gene directs the expression of an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. MAGE1 belongs to a family of genes that are expressed in a number of tumors of ... [more ▼]

The human MAGE1 gene directs the expression of an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. MAGE1 belongs to a family of genes that are expressed in a number of tumors of various histological types but not in normal tissues except testis. The MAGE genes are arranged in two groups that are located within two different regions of the human X chromosome (Xq26-qter and Xp21.3). By hybridizing mouse genomic libraries with a MAGE1 probe, we identified three homologous genes. Two of these mouse genes, Smage1 and Smage2, are more than 99% identical to each other and encode the same protein of 330 aa. The 5' noncoding region of Smage2 provides the potential for regulating the expression of the gene through several different promoters located in front of alternative first exons. The third gene, Smage3, has the structure of a processed transcript. It codes for a protein with only 11 aa substitutions with respect to the Smage1/2 product. Somatic cell hybrids and interspecific backcross analysis showed that Smage3 is autosomal and that Smage1 and Smage2 are located between the Dmd and the Ar loci on the mouse X chromosome. Since this region is syntenic to the human Xp21.1-p22.1 region, we conclude that Smage1 and Smage2 are homologous to the MAGE-Xp rather than to the MAGE-Xq genes. Smage1/2 transcripts were detected in several tumor and embryonal cell lines but not in normal mouse tissues with the exception of testis. Expression of Smage3 was found in embryos from Day 11 to Day 15. [less ▲]

Aminoglycoside Antibiotics Induce Aggregation But Not Fusion Of Negatively-Charged Liposomes

in European Journal of Pharmacology-Molecular Pharmacology Section (1995), 289(2), 321-33

The binding of aminoglycoside antibiotics to acidic phospholipids of membranes is an essential step in the development of both their renal and auditory toxicities, which could be associated with critical ... [more ▼]

The binding of aminoglycoside antibiotics to acidic phospholipids of membranes is an essential step in the development of both their renal and auditory toxicities, which could be associated with critical modifications of the membrane properties. This work examines the capacity of aminoglycosides to induce membrane aggregation and fusion. Three techniques were used in parallel: (i) measurement of the dequenching rate of a lipid-soluble fluorescent probe (octadecylrhodamine B) incorporated at self-quenched concentration in membranes; (ii) measurement of the increase in the energy transfer between two fluorescent derivatives of phospholipids; and (iii) electron microscopy of negatively-stained replicas. The results were compared with those obtained with spermine (an aggregating polycation) and melittin (a fusogenic peptide). The three approaches indicate that aminoglycosides induce liposomes aggregation, but not fusion. Aggregation is related to the capacity of each drug studied to bind phosphatidylinositol, as evaluated by its energy of interaction with this acidic phospholipid, and to its toxic potential. Membrane aggregation occurring in vivo could therefore contribute to, or be a determinant of this toxicity, which could rationally be screened for new derivatives by the methods applied here. [less ▲]

Das Siegburger Kurbuch. Original und Übersetzung

in Heimatblätter des Rhein-Sieg-Kreises (1995), 63

Compte-rendu de l'ouvrage de Claudia Kemper : Göttliche Allmacht und menschliche Verantwortung : sittlicher Wert bei archaischen Dichtern der Griechen

in Etudes Classiques (1995), 63(3-4), 383

Démarche expérimentale et robotique pédagogique. Communication présentée au colloque de l'Université du Maine, Le Mans

Conference (1995)

Influence du risque suicidaire et du desespoir sur l'amplitude de l'onde P300 dans la depression majeure.

in Neurophysiologie Clinique = Clinical Neurophysiology (1995), 25(5), 291-6

P300 amplitude represents a useful tool to assess information processing in normal and psychopathological subjects. In depressive disorders, many studies have shown a decrease of P300 amplitude and an ... [more ▼]

P300 amplitude represents a useful tool to assess information processing in normal and psychopathological subjects. In depressive disorders, many studies have shown a decrease of P300 amplitude and an increase of its latency. However, functional significance of the P300 modifications remain unclear. The aim of the study was to assess the influence of suicidal risk and hopelessness on P300 amplitude among 40 depressive inpatients. The results showed significant relationships between P300 amplitude and suicidal risk (r = -0.68, p < 0.001) and with hopelessness (r = -0.76, p < 0.001). From a clinical point of view, P300 amplitude should be considered as a psychophysiological index of suicidal risk in major depressive disorder. [less ▲]