References of "1995"
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See detailWATER-SOLUBLE NIMESULIDE SALT, AND USES THEREOF FOR THE TREATMENT OF INFLAMMATIONS
Pirotte, Bernard ULg; Piel, Géraldine ULg; Delneuville, Isabelle et al

Patent (1995)

Water-soluble nimesulide salt comprised of the product obtained from the reaction of nimesulide and L-lysine, preparation thereof, aqueous solution containing it, associations based on nimesulide with ... [more ▼]

Water-soluble nimesulide salt comprised of the product obtained from the reaction of nimesulide and L-lysine, preparation thereof, aqueous solution containing it, associations based on nimesulide with cyclodextrins, and uses thereof. [less ▲]

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See detailStructure-specific nuclease activity in yeast nucleotide excision repair protein RAD2
Habraken, Yvette ULg; Sung, Patrick; Prakash, Louise et al

in Journal of Biological Chemistry (1995), 270(50), 30194-8

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See detailSurveillance des streptocoques beta-hémolytiques du groupe B
MELIN, Pierrette ULg

Conference (1995, December 08)

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See detailDynamic properties of the transient network formed by telechelic ionomers studied by dynamic light scattering and dynamic mechanical analysis
Johannsson, Ragnar; Chassenieux, Christophe; Durand, Dominique et al

in Macromolecules (1995), 28(25), 8504-8510

Solutions of alpha,omega-sodium sulfonatopolyisoprene (alpha,omega NaPIPS) in toluene are studied using static and dynamic light scattering and dynamic mechanical analysis. At concentrations above 4 g/L ... [more ▼]

Solutions of alpha,omega-sodium sulfonatopolyisoprene (alpha,omega NaPIPS) in toluene are studied using static and dynamic light scattering and dynamic mechanical analysis. At concentrations above 4 g/L, which is well below the overlap concentration of the polymer chains (C*), a transient network is formed characterized by a plateau modulus at high frequencies and a relatively narrow viscoelastic relaxation time distribution. The intensity autocorrelation function of the transient network shows two relaxational modes: a relatively fast diffusional mode close to the co-operative diffusional mode of semidilute solutions of the unfunctionalized polymers and a slow broader mode which becomes independent of the scattering angle at a concentrations close to C*. The relation between this slow mode and the viscoelastic relaxation is discussed. Both the slow mode and the viscoelastic relaxation processes have an Arrhenius temperature dependence with the same activation energy, E(a) = 25 kJ/mol. [less ▲]

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See detailFractures osseuses et ostéodensitométrie chez l'hémodialysé
Fontaine, Marie-Anne; Zandona, R; Geavlete, E et al

Conference (1995, December 04)

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See detailThe robustness of self-organized criticality against extinctions in a tree-like model of evolution
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Europhysics Letters [=EPL] (1995), 32(7), 613-618

We investigate a so-called punctuated-equilibrium model of tree-like evolution containing extinctions for the weakest species with respect to a strength parameter r. Without extinctions (for r = 0), the ... [more ▼]

We investigate a so-called punctuated-equilibrium model of tree-like evolution containing extinctions for the weakest species with respect to a strength parameter r. Without extinctions (for r = 0), the model leads to self-organized criticality. For r not equal 0, a transition from growing trees to finite ones takes place at some critical r(c) = 0.48 +/- 0.01 value. For 0 less than or equal to r less than or similar to r(c), self-organized criticality is thus robust against extinctions of the weakest species. The size distribution of avalanches follows a power law behaviour with an exponent 3/2 which seems to be independent of the parameter r. The growing trees are found to be self-similar with a non-universal fractal dimension D-f non-trivially ranging from 2 to 1 depending on the parameter r. This constraint model opens up the field of description of various possible physical events for such an evolution model. [less ▲]

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See detailPre- and Post-Translational Regulation of Aromatase by Steroidal and Non-Steroidal Aromatase Inhibitors
Foidart, Agnès ULg; Tlemcani, O.; Harada, N. et al

in Brain Research (1995), 701(1-2), 267-78

Treatment of castrated quail with testosterone (T) reliably activates male copulatory behavior and, at the same time, increases the aromatase activity (AA), the number of aromatase-immunoreactive (ARO-ir ... [more ▼]

Treatment of castrated quail with testosterone (T) reliably activates male copulatory behavior and, at the same time, increases the aromatase activity (AA), the number of aromatase-immunoreactive (ARO-ir) cells and the concentration of aromatase mRNA as measured by RT-PCR in the brain. All these effects can be mimicked by estrogens. The behavioral effects of T can be blocked by a variety of aromatase inhibitors and, in parallel, the AA is strongly inhibited in the preoptic area (POA). We showed recently that the steroidal inhibitor, 4-OH-androstenedione (OHA) markedly decreases the immunostaining density of brain ARO-ir cells while the non-steroidal inhibitor, R76713 (racemic Vorozole; VOR) unexpectedly increased the density of this staining, despite the fact that the enzyme activity was completely inhibited. To generalize these findings and try to identify the underlying mechanism, we compared here the effects of two steroidal (OHA and androstatrienedione [ATD]) and two non-steroidal (VOR and Fadrozole [FAD]) aromatase inhibitors on the aromatase immunostaining and aromatase mRNA concentration in the brain of castrated quail concurrently treated with T. The 4 inhibitors significantly blocked the activation by T of male copulation. The two steroidal inhibitors decreased the immunostaining of brain ARO-ir cells but both VOR and FAD markedly enhanced the density of this staining. In parallel, OHA and ATD completely blocked the T-induced increase in aromatase mRNA concentration, while VOR and FAD had no effect on these RNA concentrations in the POA-anterior hypothalamus and they decreased them only slightly in the posterior hypothalamus. Taken together these results suggest that the inhibition of AA by ATD or OHA and the subsequent removal of locally produced estrogens blocks the synthesis of aromatase presumably at the transcriptional level. By contrast, the two non-steroidal inhibitors tested here block AA but in parallel increase the aromatase immunostaining. This effect does not result from an enhanced transcription and it is therefore speculated that these compounds increase either the translation of the aromatase mRNA or the half-life of the protein itself. [less ▲]

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See detailEIT: Extreme-Ultraviolet Imaging Telescope for the SOHO Mission
Delaboudinière, J.-P.; Artzner, G. E.; Brunaud, J. et al

in Solar Physics (1995), 162

The Extreme-ultraviolet Imaging Telescope (EIT) will provide wide-field images of the corona and transition region on the solar disc and up to 1.5 Ro above the solar limb. Its normal incidence multilayer ... [more ▼]

The Extreme-ultraviolet Imaging Telescope (EIT) will provide wide-field images of the corona and transition region on the solar disc and up to 1.5 Ro above the solar limb. Its normal incidence multilayer-coated optics will select spectral emission lines from Fe IX (171 Å), Fe XII (195 Å), Fe XV (284 Å), and He II (304 Å) to provide sensitive temperature diagnostics in the range from 6 × 10[SUP]4[/SUP] K to 3 × 10[SUP]6[/SUP] K. The telescope has a 45 x 45 arcmin field of view and 2.6 arcsec pixels which will provide approximately 5-arcsec spatial resolution. The EIT will probe the coronal plasma on a global scale, as well as the underlying cooler and turbulent atmosphere, providing the basis for comparative analyses with observations from both the ground and other SOHO instruments. This paper presents details of the EIT instrumentation, its performance and operating modes. [less ▲]

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See detailTolerance to Osmotic Shocks in Rats Kidney Cortex and Medulla
Gilles, Raymond ULg; Compère, Philippe ULg; el Goumzili, M. et al

in Tissue & Cell (1995), 27(6), 667-77

Kidney medulla cells of mammals have to cope with large changes in environmental osmolarity, a challenge most other mammalian cells never have to experience. In these last cells, application of osmotic ... [more ▼]

Kidney medulla cells of mammals have to cope with large changes in environmental osmolarity, a challenge most other mammalian cells never have to experience. In these last cells, application of osmotic shocks induces dramatic modifications in chromatin organization. The present paper reports on the changes of medulla cell chromatin in situ, in rat kidney slices submitted to osmotic challenges and in vitro, on preparations of extracted chromatin submitted to changes in environmental ion concentrations. Our results show that the chromatin of kidney medulla cells: (1) does not behave differently from the other mammalian chromatins when submitted in situ or in vitro to osmotic challenges; (2) presents in vitro physico-chemical characteristics similar to those of the other mammalian chromatins; and (3) is protected in vitro, as the other mammalian chromatins, from the disrupting effects of increases in inorganic ion concentrations by different compensatory organic solutes. The ability of kidney medulla cells to adapt to large increases in osmolarity could thus be related to a rapid control of the level of such compounds rather than to some rather specific, intrinsic molecular adaptations of macromolecules. [less ▲]

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See detailSpecific transcription factors control the c-erbB2 gene expression in the mammary tumor BT-474 cells.
Grooteclaes, Madeleine; Pasleau, Françoise ULg; Garsoux, G. et al

Conference (1995, December)

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See detailIn vitro drug sensitivity and clinical aspects of Plasmodium falciparum malaria in African children
Carme, Bernard; Gay, Frederic; Ndounga, Mathieu et al

in Tropical Medicine and Parasitology : Official Organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft für Technische Zusammenarbeit (1995), 46(4), 270-274

In vitro Plasmodium falciparum drug sensitivity was investigated in 115 brazzavillians children, between 1 year and 10 years of age. On the basis of clinical aspects, four groups were constituted: Group 1 ... [more ▼]

In vitro Plasmodium falciparum drug sensitivity was investigated in 115 brazzavillians children, between 1 year and 10 years of age. On the basis of clinical aspects, four groups were constituted: Group 1: 39 asymptomatic school children, Group 2: 16 children with uncomplicated malaria, Group 3: 40 with severe but not pernicious malaria and Group 4: 20 with pernicious malaria. The drugs tested were chloroquine (CQ), quinine (QN) and mefloquine (MQ). The sensitivity level was assessed by a 48-hour in vitro maturation test involving the uptake of tritiated hypoxanthine, the initial blood level of parasite being > or = 0.1% in all cases. For QN and MQ, the median IC50 values showed no significant difference related to clinical status, age or parasitaemia levels. For CQ, the proportion of resistant strains and the 50 inhibitory concentration (IC50) values were greater in the cases of children hospitalised for malaria but there were no differences related to clinical severity of these hospitalised children nor, within each group, to the age or parasitaemia levels. The percentage of subjects with an IC50 value greater than the 90 percentile of the IC50 of the asymptomatic group, which we propose as the severity index related to chemoresistance, was 15% for uncomplicated malaria, 38% for severe but non-pernicious forms and 35% for pernicious malaria. The IC50 for QN was significantly higher in CQ-resistant strains and there was a positive correlation for CQ vs QN and for QN vs MQ. [less ▲]

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See detailPlasma Membrane-Dependent Activation of Gelatinase a in Human Vascular Endothelial Cells
Lewalle, J. M.; Munaut, Carine ULg; Pichot, B. et al

in Journal of Cellular Physiology (1995), 165(3), 475-83

The initiation of the angiogenic process requires a locally confined and time-limited proteolysis of the basement membrane (BM) components at the site of new vessel sprout. Gelatinase A, a member of the ... [more ▼]

The initiation of the angiogenic process requires a locally confined and time-limited proteolysis of the basement membrane (BM) components at the site of new vessel sprout. Gelatinase A, a member of the matrix metalloproteinase family, degrades BM type IV collagen and is involved in the BM breakdown by migrating tumor cells and endothelial cells (EC). Gelatinase A is synthesized as latent proenzyme and must be activated in order to express its proteolytic activity. A plasma membrane-dependent mechanism of activation has been described for several tumor and transformed cells lines. In the present study, we show that latent (72 kD) and mature (62-59 kD) forms of gelatinase A are present in EC membrane fraction from Triton X-114 extract while only latent form is found in the cytosolic fraction. The incubation of EC membrane fraction with exogenous latent gelatinase A resulted in a significant activation giving rise to 62-59 kD mature forms. 12-O-tetradecanoylphorbol-13-acetate (TPA), a strong potentiator of angiogenesis in vitro and in vivo, increases the amount of both latent and activated forms of gelatinase A in EC membrane fraction as well as the ability of this latter fraction to activate exogenous latent gelatinase A. We show that the mRNA transcript coding for the membrane-integrated MMP, the MT-MMP, previously described as a potential gelatinase A activator in invasive tumor cells is also expressed in vascular EC and is regulated through a TPA sensitive process. This enzyme may be responsible for membrane-dependent gelatinase A activation in normal vascular EC and may therefore be a determinant in the control of BM proteolysis during angiogenesis. [less ▲]

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See detailNouvelles approches sur le concept de personnalité
Garcet, Serge ULg

Conference (1995, December)

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See detailLa communication cryptocrine intrathymique et la tolérance immunitaire centrale au soi neuroendocrine
Geenen, Vincent ULg

Thèse d’agrégation de l’enseignement supérieur (1995)

Tant au cours de la phylogenèse qu'au cours de l'ontogenèse, le thymus apparaît comme un point de rencontre crucial entre les deux grands systèmes de communication intercellulaire, les systèmes ... [more ▼]

Tant au cours de la phylogenèse qu'au cours de l'ontogenèse, le thymus apparaît comme un point de rencontre crucial entre les deux grands systèmes de communication intercellulaire, les systèmes neuroendocrine et immunitaire. Dans le thymus, selon le mode primitif de la communication cryptocrine, les précurseurs neuroendocrines thymiques sont capables d'influencer les stades précoces de la réponse immunitaire. En même temps, les précurseurs des cellules T sont éduqués à reconnaître et à tolérer les principales fonctions neuroendocrines. Ainsi, le répertoire thymique des précurseurs apparentés à différentes familles neuroendocrine transpose à l'échelon moléculaire le double rôle du thymus dans les sélections positive et négative des lymphocytes T. [less ▲]

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See detailThe use of styrenic copolymers to generate polyimide nanofoams
Hedrick, James; Hawker, Craig J; DiPietro, R. et al

in Polymer (1995), 36(25), 4855-4866

New routes for the synthesis of high T-g thermally stable polymer foams with pore sizes in the nanometre regime have been developed. Foams were prepared by casting well-defined microphase-separated block ... [more ▼]

New routes for the synthesis of high T-g thermally stable polymer foams with pore sizes in the nanometre regime have been developed. Foams were prepared by casting well-defined microphase-separated block copolymers comprising a thermally stable block and a thermally labile material. At properly designed volume fractions, the morphology provides a matrix of the thermally stable material with the thermally labile material as the dispersed phase. Upon thermal treatment, the thermally unstable block undergoes thermolysis generating pores, the size and shape of which are dictated by the initial copolymer morphology. Several labile blocks were surveyed including polystyrene, poly(alpha-methylstyrene) and several alpha-methylstyrene/styrene copolymers. Each of these polymers can unzip to its monomer upon heating; however, the rate is substantially slower for polystyrene. The copolymers were synthesized through either the poly(amic acid) precursor, followed by chemical imidization to the polyimide form, or the poly(amic alkyl ester) precursor followed by thermal imidization. The decomposition of the labile coblock was studied by thermogravimetric and dynamic mechanical analysis. Upon decomposition, the foams showed pore sizes in the nanometre regime along with the expected reduction in mass density. [less ▲]

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See detailDiscussions about the Bp-d diagrams in polynomial for marine propeller series
Marchal, Jean ULg; Shen, Yide ULg; Kicheva, D.

in RINA (1995), volume 137

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See detailEtat de l’environnement Wallon: le transport
Marchal, Jean ULg

Report (1995)

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See detailLes clivages entérinés dans la constitution belge
Verjans, Pierre ULg

in Agenda Interculturel (1995), (139), 19-24

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