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See detailEvidence for Free Radical Formation During Human Kidney Transplantation
Pincemail, Joël ULg; Defraigne, Jean-Olivier ULg; Franssen, Christine ULg et al

in Free Radical Biology & Medicine (1993), 15(3), 343-8

Fourteen patients undergoing kidney transplantation were studied for evidence of the production of free radicals as assessed by the measurement of vitamin E (an index of lipid peroxidation) and of ... [more ▼]

Fourteen patients undergoing kidney transplantation were studied for evidence of the production of free radicals as assessed by the measurement of vitamin E (an index of lipid peroxidation) and of myeloperoxidase (a marker of neutrophil activation) in the systemic blood. Early (2 min) and late revascularization (30 min) of the kidney were respectively associated with a significant decrease of 35.5 and 40% of the initial level of plasma vitamin E. This consumption paralleled to the decrease of the vitamin E/total lipids ratio, a better indicator of vitamin E status. Heparin administration preceding renal artery clamping resulted in a twofold significant increase of baseline plasma myeloperoxidase (MPO) level (523 +/- 214 ng/ml). At kidney reperfusion, MPO concentration rose again and reached a maximum value of 1,653 +/- 882 ng/ml, indicating the presence of considerable neutrophil activation. A return to the baseline value was observed after 30 min of reperfusion. A short discussion about the possible origin of this MPO increase is given. Taken together, these data strongly suggest that free radical production, leading to lipid peroxidation phenomena, can occur within the early phase of kidney revascularization. Preliminary data using electron spin resonance with the spin-trapping technique strengthen this hypothesis. [less ▲]

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See detailMolecular alterations in breast cancers : deregulation of c-erbB2 gene expression.
Gol-Winkler, Rose; Pasleau, Françoise ULg; Grooteclaes, Madeleine et al

Conference (1993, September)

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See detailChris Marker's Sans Soleil
Van Cauwenberge, Geneviève ULg

Conference (1993, September)

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See detailManoeuvrability of ships in shallow and restricted waters
Marchal, Jean ULg

Conference (1993, September)

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See detailResistance and flow of ships in shallow and restricted waters
Marchal, Jean ULg

Conference (1993, September)

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See detailLigamentoplasties du genou : Intérêt d'un renforcement musculaire préopératoire
Croisier, Jean-Louis ULg; Delcour, Jean-Pierre; Crielaard, Jean-Michel ULg

in Actes du 8ème Congrès National de la Société française de Médecine de Rééducation et de Réadaptation (1993, September)

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See detailAttachment of the Gammaherpesvirus Bovine Herpesvirus 4 Is Mediated by the Interaction of Gp8 Glycoprotein with Heparinlike Moieties on the Cell Surface
Vanderplasschen, Alain ULg; Bublot, M.; Dubuisson, J. et al

in Virology (1993), 196(1), 232-40

Cell surface heparan sulfate serves as the initial receptor for several alphaherpesviruses and at least one betaherpesvirus. This study shows that during the process of adsorption of the gammaherpesvirus ... [more ▼]

Cell surface heparan sulfate serves as the initial receptor for several alphaherpesviruses and at least one betaherpesvirus. This study shows that during the process of adsorption of the gammaherpesvirus bovine herpesvirus 4 (BHV-4), the viral glycoprotein gp8 interacts with heparinlike moieties of cell surface. This conclusion is based on the following findings. (i) Soluble heparin was capable of blocking BHV-4 infection of Georgia bovine kidney cells by inhibition of viral attachment. (ii) Nevertheless, after virus adsorption to Georgia bovine kidney cells, heparin was partially capable of removing adsorbed virus. (iii) Enzymatic digestion of cell surface heparan sulfate but not of chondroitin sulfates A, B, and C reduced the binding of the virus to the cells, and rendered the cells partially resistant to infection. (iv) Radiolabeled purified BHV-4 bound to wild-type Chinese hamster ovary cells, whereas binding of the virus to mutant Chinese hamster ovary cell lines that where deficient in either all glycosaminoglycans or only heparan sulfate was significantly impaired. (v) Using heparin-affinity chromatography, gp8 glycoprotein was shown to bind specifically to immobilized heparin and to elute in the presence of soluble heparin. These data together showed that the gammaherpesvirus BHV-4, like alphaherpesviruses and one betaherpesvirus, adsorbs to cells by binding to cell surface heparin-like moieties. Therefore, this study extends the group of herpesviruses interacting with heparinlike moieties at the cell surface to a member of the gammaherpesvirinae subfamily. [less ▲]

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See detailStability of a FBTCS Scheme Applied to the Propagation of Shallow-Water Inertia-Gravity Waves on Various Space Grids
Beckers, Jean-Marie ULg; Deleersnijder, Eric

in Journal of Computational Physics (1993), 108(1), 94-104

The equations governing the propagation of inertia-gravity waves in geophysical fluid flows are discretized on the A, B, C, and D grids according to the classical forward-backward on time and centered on ... [more ▼]

The equations governing the propagation of inertia-gravity waves in geophysical fluid flows are discretized on the A, B, C, and D grids according to the classical forward-backward on time and centered on space (FBTCS) numerical scheme. The von Neumann stability analysis is performed and it is shown that the stability condition of the inertia-gravity waves scheme is more restrictive, at least by a factor of , than that concerning pure gravity waves, whatever the magnitude of the Coriolis parameter. Finally, the general necessary and sufficient stability condition is derived for the A, B and C grids, while, on the D grid, the stability condition has been obtained only in particular cases. [less ▲]

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See detailBPDZ 44 : a new and potent activator of ATP-sensitive K+ channels
Lebrun, P.; Pirotte, Bernard ULg; Antoine, M. H. et al

Poster (1993, September)

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See detailComment rendre LOTOS apte à spécifier des systèmes temps réel ?
Leduc, Guy ULg; Léonard, Luc

in Dssouli, Rachida; Bochmann, Gregor (Eds.) Ingénierie des Protocoles (1993, September)

We explain and justify by examples our proposed timed extension of LOTOS. The examples cover protocol functions and service facilities that are frequently encountered in practice or are inspired by ... [more ▼]

We explain and justify by examples our proposed timed extension of LOTOS. The examples cover protocol functions and service facilities that are frequently encountered in practice or are inspired by existing ones, such as timers, watchdogs, delays, isochronism, multimedia, rate control, ... The semantics of the language is presented after, and its properties discussed more formally. We think that the systematic application of formal temporal techniques to this kind of examples is unavoidable to convince of the pertinence of the design choices. The practical effectiveness of a formalism is as important as the associated mathematical properties. [less ▲]

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See detailTechnological aspects of biopesticides production. Dans "Biological control of fruit and foliar diseases" Proceedings of an EC workshop, Gembloux, September 16-17.
Thonart, Philippe ULg; Jacques, Ph.; Cornelius, C. et al

in Proceedings "Biological control of fruit and foliar diseases" (1993, September)

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See detailIn vitro antagonism of two potential biopesticides Bacillus subtilis and Pseudomonas fluorescens : biochemical aspects.
Jacques, Ph.; Hbid, Ch.; Ongena, Marc ULg et al

in Proceedings "Biological control of fruit and foliar diseases" (1993, September)

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See detailPerformance of belgian hospitals
Fecher-Bourgeois, Fabienne ULg

Conference (1993, September)

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See detailAcremonium luzulae produces an antifungal agent with a very strong activity.
Moussaif, M.; Jacques, Ph.; Thonart, Philippe ULg

Poster (1993, September)

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See detailAcute Biochemical Variations Induced by Four Different Calcium Salts in Healthy Male Volunteers
Reginster, Jean-Yves ULg; Denis, D.; Bartsch, Valérie ULg et al

in Osteoporosis International : A Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis & the National Osteoporosis Foundation of the USA (1993), 3

Calcium (Ca) supplements have positive effects in growing children, reduce bone loss in late-postmenopausal women with a low calcium diet and, in association with vitamin D3 supplements, may reduce non ... [more ▼]

Calcium (Ca) supplements have positive effects in growing children, reduce bone loss in late-postmenopausal women with a low calcium diet and, in association with vitamin D3 supplements, may reduce non-vertebral fracture rates in elderly women. However, for many formulated pharmaceutical products their relative beneficial effects have not been conclusively established. We have compared the acute (6 h) metabolic responses following oral administration of two preparations of calcium gluconolactate and carbonate (CG and CG'), tricalcium phosphate (TCP) and calcium citrate (CC), given on separate occasions in each of 10 healthy young male volunteers. The subjects fasted overnight for 12 h and continued to fast during the experimental procedure. A 1000 mg dose of each Ca salt was ingested at weekly intervals. Blood was drawn after 30, 60, 90, 120, 180, 240, 300 and 360 min for measurement of serum Ca, phosphorus (P), parathyroid hormone (PTH) and whole plasma calcitonin (iCT). All Ca supplements induced significant (+6.4% to +8.1%; p < 0.01) increases in Ca and significant suppression of PTH (-37.4% to -57.4%; p < 0.01). Comparison of response curves revealed significantly (p < 0.01) more marked Ca increase and PTH suppression with CC than with the other three Ca salts. CG' and CC induced marginal decreases in serum P and the overall curve of P variations was different for TCP compared with CG, CG' and CC. No significant variation of iCT was recorded during the test.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailSous le swing de la croix
Sacré, Robert ULg

in Soul Bag (1993), (132), 12-16

Des Hymnes aux Negro Spirituals et aux Gospel Songs

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See detailPrevention of Osteoporosis with Nasal Salmon Calcitonin: Effect of Anti-Salmon Calcitonin Antibody Formation
Reginster, Jean-Yves ULg; Gaspar, S; Deroisy, Rita ULg et al

in Osteoporosis International : A Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis & the National Osteoporosis Foundation of the USA (1993), 3

The amino acid sequence of salmon calcitonin (SCT) differs considerably from that of the human hormone and specific antibodies (Ab) develop in a significant proportion of patients after parenteral or ... [more ▼]

The amino acid sequence of salmon calcitonin (SCT) differs considerably from that of the human hormone and specific antibodies (Ab) develop in a significant proportion of patients after parenteral or nasal administration of SCT. Controversy remains regarding the functional importance of these Ab. We report on the development of specific anti-SCT Ab in a population of postmenopausal women receiving nasal SCT for prevention of postmenopausal bone loss, and compare the effects of nasal SCT in women with or without Ab. Thirty-nine per cent of women developed Ab after 6 months of treatment with SCT, 52% after 12 months, and 61% after 18 and 24 months. After 24 months the AB titre was 3.47-17.7 x 10(-9) M/l (mean +/- SD: 13.3 +/- 3.1 x 10(-9) M/l). No significant differences appeared between the changes in lumbar bone mineral density (BMD) measured in the whole population (n = 44) (mean +/- SD: +1.06 +/- 3.9%), the patients without Ab (n = 17) (+0.05 +/- 3.7%) or in those with Ab (n = 27) (+1.7 +/- 4.6%). During the same period, a control population randomly assigned to a 500 mg/day calcium intake showed a significant loss of lumbar BMD (-4.57 +/- 4.9%) (p < 0.01). In conclusion, in healthy postmenopausal women nasal SCT seems to maintain the same preventive effect against bone loss whether or not Ab are present. [less ▲]

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