Mode of interaction between beta-lactam antibiotics and the exocellular DD-carboxypeptidase--transpeptidase from Streptomyces R39; Frère, Jean-Marie ; Ghuysen, Jean-Marie et alin Biochemical Journal (1976), 155(3), 623-629 The exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R39 is inhibited by beta-lactam antibiotics according to the same general scheme of reaction as the exocellular DD-carboxypeptidase ... [more ▼] The exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R39 is inhibited by beta-lactam antibiotics according to the same general scheme of reaction as the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61. However, the values for the kinetic constants involved in the reaction are very different for the two enzymes and provide an explanation for the observation that the R39 enzyme is more sensitive to beta-lactam antibiotics than the R61 enzyme. Further, particular beta-lactams influence the kinetic constants to different extents depending on the source of the enzyme, so that a physical basis for the spectrum of antibiotic activity against particular enzyme systems is provided. [less ▲] Detailed reference viewed: 8 (0 ULg) Partial differential matrix equations for the inverse problem of scattering theory; Rochus, Pierre ![]() in Journal of Mathematical Physics (1976), 17 Sufficient conditions for the existence of a continuous translation operator are found in the case of a system of differential equations in which the matrix potential has the singularity of the ... [more ▼] Sufficient conditions for the existence of a continuous translation operator are found in the case of a system of differential equations in which the matrix potential has the singularity of the centripetal term. The sufficient conditions are found in terms of moments of the nuclear potential. The method used employs the Riemann Green's function. Threshold energies introduce a threshold energy dependence into the translation kernel and lead to a requirement of an exponential decrease for terms of the matrix potential. [less ▲] Detailed reference viewed: 20 (1 ULg) Ecriture romanesque et théorie du signeDumortier, Jean-Louis ![]() in Education (1976) Detailed reference viewed: 12 (4 ULg) L'école et les textesDumortier, Jean-Louis ![]() in Revue de la Direction Générale de l’Organisation des Etudes (1976) Detailed reference viewed: 4 (0 ULg) Formulation de l'étude linéarisée des structures précontraintesDebongnie, Jean-François ![]() Report (1976) Pre-stress may have a consderable effect on the behaviour of thin walled structures. The general case is non linear. However, there is a class of situations where the study remains linear, as for example ... [more ▼] Pre-stress may have a consderable effect on the behaviour of thin walled structures. The general case is non linear. However, there is a class of situations where the study remains linear, as for example, a plate with a membranar pre-stress. The present paper focuses on the basic hypotheses of such a linearized analysis an on its exact formulation. [less ▲] Detailed reference viewed: 13 (1 ULg) The irresistible need for educational researchDe Landsheere, Gilbert ![]() Conference (1976, June) The function of research is to perfect the tools of education and to manufacture new ones. Research opens up perspectives and informs teachers. The whole of the education system and all its components ... [more ▼] The function of research is to perfect the tools of education and to manufacture new ones. Research opens up perspectives and informs teachers. The whole of the education system and all its components should be investigated if research is to be comprehensive and successful. Highly qualified teams of researchers are essential, bringing a variety of interests, knowledge, and points of view. Education is a human venture and also a realm of contingencies; it is important that educational research take into account the teacher's cultural background, intellectual limitations, needs, frustrations, and the real problems faced in the classroom. Full understanding and communication between researchers and teachers must exist if change and action are to result from educational exploration, evaluation, and future planning. (JD) [less ▲] Detailed reference viewed: 6 (1 ULg) Het 'Woordenboek van de Brabantse Dialecten': een grensoverschrijdend projectVromans, Joseph ![]() Speech (1976) Detailed reference viewed: 7 (0 ULg) On the evolution of ionized gas around hot starsManfroid, Jean ![]() in Astrophysics & Space Science (1976), 41 The initial evolution of a uniform H II region around a star of 36 solar masses is described. The general equations of the problem are solved numerically by a finite-difference method. Forbidden-line ... [more ▼] The initial evolution of a uniform H II region around a star of 36 solar masses is described. The general equations of the problem are solved numerically by a finite-difference method. Forbidden-line emission by ions of C, N, O, and Ne is taken into account. [less ▲] Detailed reference viewed: 5 (0 ULg) A bright rim in RCW 62.; Manfroid, Jean ![]() in Astronomy and Astrophysics (1976), 48 Abstract image available at: http://cdsads.u-strasbg.fr/abs/1976A&A....48..213D Detailed reference viewed: 8 (0 ULg) Fate of thiazolidine ring during fragmentation of penicillin by exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61Frère, Jean-Marie ; Ghuysen, Jean-Marie ; et alin Nature (1976), 260(5550), 451-454 LIKE various beta-lactamases, acylases and esterases1, the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61 degrades benzylpenicillin and other beta-lactam antibiotics2-4. The R61 enzyme ... [more ▼] LIKE various beta-lactamases, acylases and esterases1, the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61 degrades benzylpenicillin and other beta-lactam antibiotics2-4. The R61 enzyme, however, markedly differs from the other penicillin-degrading enzymes in causing fragmentation of the penicillin nucleus. By using 8-14C-benzylpenicillin (benzyl labelled) as substrate, one of the fragments produced was shown to be 14C-phenylacetylglycine5. The reaction with the R61 enzyme is also peculiar in that it is a slow process. This is because of the long half life of the stoichiometnc complex transitorily formed between the antibiotic and the enzyme. Thus, for example, the value of the half life for the complex formed with benzylpenicillin is 80 min in 10 mM phosphate buffer (pH 7.0) and at 37 °C. As breakdown of the complex proceeds, however, phenylacetylglycine (when benzylpenicillin is used as substrate) is released and the enzyme concomitantly recovers its ability to bind penicillin. We have now characterised the fragment (hereby designated as the Y product) arising from the thiazolidine ring of penicillin as a result of the fragmentation of the antibiotic molecule by the R61 enzyme. [less ▲] Detailed reference viewed: 11 (1 ULg) Pour l'analyse structuraleDumortier, Jean-Louis ![]() in Revue de la Direction Générale de l’Organisation des Etudes (1976) Detailed reference viewed: 5 (1 ULg) Comparative ultrastructural study of the effects of serum-free medium and dibutyryl-cyclic AMP on newborn rat astroblastsMoonen, Gustave ; ; in Cell & Tissue Research (1976), 167(2), 221-7 Detailed reference viewed: 5 (0 ULg) The direction of peptide trimer synthesis from the donor-acceptor substrate Nalpha-(acetyl)-Nepsilon-(glycyl)-L-lysyl-D-alanyl-D-alanine by the exocellular dd-carboxypeptidase-transpeptidase of Streptomyces R61Frère, Jean-Marie ; Ghuysen, Jean-Marie ; et alin FEBS Letters (1976), 63(1), 112-116 Detailed reference viewed: 3 (0 ULg) Repeated Observations of the Ca II (H and K) Lines in the Spectrum of the A0ep Star with IR Excess HD 190073; Interpretation via a Resonance Scattering MechanismSurdej, Jean ; Swings, Jean-Pierre ![]() in Bulletin of the American Astronomical Society (1976, March) Detailed reference viewed: 6 (0 ULg) A Burning Sound from Detroit - interview Eddie BurnsSacré, Robert ![]() Article for general public (1976) Detailed reference viewed: 12 (0 ULg) EDDIE BURNS PortraitSacré, Robert ![]() Article for general public (1976) Detailed reference viewed: 9 (0 ULg) Rocket-borne baffled photometer - Design and calibration; Gérard, Jean-Claude ![]() in Applied Optics (1976), 15 The design of an interference filter twin photometer suitable for the observation by rocket of the daytime magnetospheric cleft aurora at 2761 A and 5200 A is presented. The two-stage baffling system test ... [more ▼] The design of an interference filter twin photometer suitable for the observation by rocket of the daytime magnetospheric cleft aurora at 2761 A and 5200 A is presented. The two-stage baffling system test and the absolute calibration procedure are described with some detail. [less ▲] Detailed reference viewed: 19 (0 ULg) Rocket and ground-based measurements of the dayside magnetospheric cleft from Cape Parry, N.W.T.; ; et al in Geophysical Research Letters (1976), 3 On Dec. 6, 1974, a Black Brant VD rocket was launched from Cape Parry, N.W.T., into the dayside magnetospheric cleft. The prime launch criterion was the detection of 6300-A emission by two ground-based ... [more ▼] On Dec. 6, 1974, a Black Brant VD rocket was launched from Cape Parry, N.W.T., into the dayside magnetospheric cleft. The prime launch criterion was the detection of 6300-A emission by two ground-based scanning photometers, but support was provided by two ionosondes. The payload passed through a narrow region of soft electron precipitation, a broader region of enhanced electron densities, and a similarly broad region of O I 5577-A and 6300-A emission. At apogee (236 km), the payload had not penetrated into the 5200-A emission, which had a very sharp equatorward boundary and extended far into the polar cap, presumably as a result of antisunward convection. [less ▲] Detailed reference viewed: 6 (0 ULg) Observations of southern nebulae; Houziaux, Léo ; Manfroid, Jean ![]() in Astrophysics & Space Science (1976), 39 Spectroscopic observations of 10 H II regions in the southern hemisphere are presented. The observations cover the spectral region 3600-8000 A. Detailed reference viewed: 2 (0 ULg) Effects of dibutyryl cyclic AMP on cultured brain cells from chick embryos of different ages.Moonen, Gustave ; in Experientia (1976), 32(1), 40-42 Detailed reference viewed: 3 (0 ULg) |
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